EMD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.04861408
2translational termination (GO:0006415)5.80075813
3ribosomal small subunit biogenesis (GO:0042274)5.19602836
4ribosomal small subunit assembly (GO:0000028)5.08981000
5translational elongation (GO:0006414)5.00361341
6nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.82785170
7proline biosynthetic process (GO:0006561)4.76059024
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.75557187
9protein targeting to ER (GO:0045047)4.64373259
10translational initiation (GO:0006413)4.63948534
11cotranslational protein targeting to membrane (GO:0006613)4.60154031
12viral life cycle (GO:0019058)4.60007312
13maturation of SSU-rRNA (GO:0030490)4.58315917
14cellular protein complex disassembly (GO:0043624)4.48972771
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.42848163
16COPI coating of Golgi vesicle (GO:0048205)4.40559715
17Golgi transport vesicle coating (GO:0048200)4.40559715
18protein localization to endoplasmic reticulum (GO:0070972)4.25055121
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.18546216
20protein complex disassembly (GO:0043241)4.11980767
21regulation of mammary gland epithelial cell proliferation (GO:0033599)3.92522074
22DNA unwinding involved in DNA replication (GO:0006268)3.81919883
23macromolecular complex disassembly (GO:0032984)3.78499802
24protein retention in ER lumen (GO:0006621)3.70477805
25protein maturation by protein folding (GO:0022417)3.67357473
26DNA strand renaturation (GO:0000733)3.66959795
27formation of translation preinitiation complex (GO:0001731)3.64831237
28negative regulation of erythrocyte differentiation (GO:0045647)3.64458306
29pentose-phosphate shunt (GO:0006098)3.59980591
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.57128263
31antigen processing and presentation via MHC class Ib (GO:0002475)3.54327715
32regulation of early endosome to late endosome transport (GO:2000641)3.53233747
33nuclear-transcribed mRNA catabolic process (GO:0000956)3.51881315
34regulation of protein heterodimerization activity (GO:0043497)3.48140511
35protein localization to kinetochore (GO:0034501)3.46887937
36folic acid-containing compound biosynthetic process (GO:0009396)3.41759105
37ribosomal large subunit biogenesis (GO:0042273)3.41057258
38mRNA catabolic process (GO:0006402)3.36114869
39positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.31106799
40heterochromatin organization (GO:0070828)3.28244162
41RNA catabolic process (GO:0006401)3.26608312
42negative regulation of cell size (GO:0045792)3.26355873
43negative regulation of RNA splicing (GO:0033119)3.24968270
44DNA strand elongation involved in DNA replication (GO:0006271)3.24587915
45histone arginine methylation (GO:0034969)3.21787967
46T cell apoptotic process (GO:0070231)3.21255710
47protein localization to chromosome, centromeric region (GO:0071459)3.20398803
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16025017
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15046433
50protein targeting to membrane (GO:0006612)3.12759606
51ribonucleoprotein complex biogenesis (GO:0022613)3.08462485
52DNA strand elongation (GO:0022616)3.06999622
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06754167
54nucleobase-containing small molecule interconversion (GO:0015949)3.05686657
55mitotic chromosome condensation (GO:0007076)3.04097607
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04059061
57* mitotic nuclear envelope disassembly (GO:0007077)3.03722427
58DNA replication initiation (GO:0006270)3.02326701
59glucose catabolic process (GO:0006007)2.98834533
60telomere maintenance via semi-conservative replication (GO:0032201)2.96719793
61trophectodermal cell differentiation (GO:0001829)2.95528513
62NADPH regeneration (GO:0006740)2.92115986
63pentose metabolic process (GO:0019321)2.91032574
64nuclear pore organization (GO:0006999)2.90132125
65nuclear pore complex assembly (GO:0051292)2.89344282
66dosage compensation (GO:0007549)2.88735094
67activation of MAPKKK activity (GO:0000185)2.87620225
68peptidyl-arginine N-methylation (GO:0035246)2.87107705
69peptidyl-arginine methylation (GO:0018216)2.87107705
70* membrane disassembly (GO:0030397)2.87071094
71* nuclear envelope disassembly (GO:0051081)2.87071094
72GDP-mannose metabolic process (GO:0019673)2.84564694
73translation (GO:0006412)2.83590335
74intracellular estrogen receptor signaling pathway (GO:0030520)2.83128540
75lymphocyte apoptotic process (GO:0070227)2.82914296
76peptidyl-lysine dimethylation (GO:0018027)2.80823875
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79966441
78spliceosomal tri-snRNP complex assembly (GO:0000244)2.78432545
79modulation by symbiont of host cellular process (GO:0044068)2.78371617
80proline metabolic process (GO:0006560)2.77683547
813-UTR-mediated mRNA stabilization (GO:0070935)2.76344315
82negative regulation of granulocyte differentiation (GO:0030853)2.74696812
83modulation by virus of host process (GO:0019054)2.74303187
84adherens junction assembly (GO:0034333)2.73025736
85regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.72362928
86glucose 6-phosphate metabolic process (GO:0051156)2.71558522
87regulation of chromatin binding (GO:0035561)2.71245422
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.71177876
89DNA replication-dependent nucleosome assembly (GO:0006335)2.71083940
90DNA replication-dependent nucleosome organization (GO:0034723)2.71083940
91mitotic sister chromatid segregation (GO:0000070)2.70299657
92regulation of translational termination (GO:0006449)2.70279153
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68617188
94RNA stabilization (GO:0043489)2.68004505
95mRNA stabilization (GO:0048255)2.68004505
96NIK/NF-kappaB signaling (GO:0038061)2.64166909
97negative regulation of mRNA processing (GO:0050686)2.63388764
98response to peptidoglycan (GO:0032494)2.62810215
99protein-DNA complex disassembly (GO:0032986)2.61206116
100nucleosome disassembly (GO:0006337)2.61206116
101focal adhesion assembly (GO:0048041)2.60560580
102cell-substrate adherens junction assembly (GO:0007045)2.60560580
103sister chromatid segregation (GO:0000819)2.56108667
104negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.55124862
105regulation of monocyte differentiation (GO:0045655)2.55104645
106telomere maintenance via recombination (GO:0000722)2.53991736
107pre-miRNA processing (GO:0031054)2.53609805
108DNA replication checkpoint (GO:0000076)2.53059295
109mitotic recombination (GO:0006312)2.52711964
110regulation of translational fidelity (GO:0006450)2.52073227
111rRNA processing (GO:0006364)2.50368673
112maternal placenta development (GO:0001893)2.49675274
113protein insertion into membrane (GO:0051205)2.48035291
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.47929403
115DNA duplex unwinding (GO:0032508)2.47242010
116positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.46331872
117regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.46331872
118protein complex localization (GO:0031503)2.46188547
119apoptotic process involved in morphogenesis (GO:0060561)2.45602240
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43272177
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.43122279
122negative regulation of necroptotic process (GO:0060546)2.42951655
123DNA geometric change (GO:0032392)2.42371985
124mRNA splicing, via spliceosome (GO:0000398)2.41673789
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.41673789
126RNA splicing, via transesterification reactions (GO:0000375)2.40206585
127rRNA metabolic process (GO:0016072)2.40203891
128IMP biosynthetic process (GO:0006188)2.39975496
129positive thymic T cell selection (GO:0045059)2.39520293
130negative regulation of histone methylation (GO:0031061)2.39065179
131* nuclear envelope organization (GO:0006998)2.39009680
132regulation of sister chromatid cohesion (GO:0007063)2.38986951
133protein localization to endosome (GO:0036010)2.38670392
134telomere maintenance via telomere lengthening (GO:0010833)2.38183594
135nucleotide salvage (GO:0043173)2.37914476
136negative regulation of DNA-templated transcription, elongation (GO:0032785)2.37864180
137chromatin assembly (GO:0031497)2.37853546
138activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.37708177
139regulation of histone H3-K27 methylation (GO:0061085)2.35272920
140positive regulation of nuclease activity (GO:0032075)2.35133483
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34559342
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.34559342
143modulation by symbiont of host immune response (GO:0052553)2.34559342
144positive regulation by symbiont of host defense response (GO:0052509)2.34559342
145modulation by symbiont of host defense response (GO:0052031)2.34559342
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34559342
147stress fiber assembly (GO:0043149)2.34555989
148ncRNA 3-end processing (GO:0043628)2.34353785
149negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.34115653
150negative regulation of mRNA metabolic process (GO:1903312)2.33624962
151amyloid precursor protein catabolic process (GO:0042987)2.33584586
152NADH metabolic process (GO:0006734)2.33351763
153regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33312295
154positive regulation of myotube differentiation (GO:0010831)2.33271401
155pinocytosis (GO:0006907)2.31596385
156mitochondrial fusion (GO:0008053)2.31189536
157regulation of gene silencing by RNA (GO:0060966)2.30841905
158regulation of posttranscriptional gene silencing (GO:0060147)2.30841905
159regulation of gene silencing by miRNA (GO:0060964)2.30841905
160positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.30668747
161nodal signaling pathway (GO:0038092)2.28776884
162alternative mRNA splicing, via spliceosome (GO:0000380)2.28479325
163chromatin assembly or disassembly (GO:0006333)2.28143316
164monosaccharide biosynthetic process (GO:0046364)2.27862551
165termination of RNA polymerase II transcription (GO:0006369)2.26969829
166spliceosomal complex assembly (GO:0000245)2.25946412
167UV protection (GO:0009650)2.24913186
168ribosome biogenesis (GO:0042254)2.24833154
169embryonic process involved in female pregnancy (GO:0060136)2.24733340
170regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.23312418
171positive regulation of chromosome segregation (GO:0051984)2.21714001
172peptidyl-arginine omega-N-methylation (GO:0035247)2.19488590
173nucleotide-excision repair, DNA gap filling (GO:0006297)2.18844506
174positive regulation of SMAD protein import into nucleus (GO:0060391)2.18326745
175Arp2/3 complex-mediated actin nucleation (GO:0034314)2.18247127
176histone H2A monoubiquitination (GO:0035518)2.17788507
177thymic T cell selection (GO:0045061)2.15743387
178regulation of mRNA stability (GO:0043488)2.15496765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.38804942
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.71759585
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47687163
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.33702226
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.26248519
6MYC_22102868_ChIP-Seq_BL_Human3.00508889
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72718297
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59831226
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58151566
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52750586
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.44104118
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38921822
13LXR_22292898_ChIP-Seq_THP-1_Human2.37424746
14VDR_21846776_ChIP-Seq_THP-1_Human2.20651512
15XRN2_22483619_ChIP-Seq_HELA_Human2.10132623
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04958007
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97378713
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92583725
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89597804
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89353342
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69560665
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68912085
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.66448476
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65143964
25* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64810793
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.62604620
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.62328399
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61025211
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60321875
30TCF7_22412390_ChIP-Seq_EML_Mouse1.59564478
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.54511367
32TTF2_22483619_ChIP-Seq_HELA_Human1.52839756
33MAF_26560356_Chip-Seq_TH1_Human1.52697572
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50301136
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49990082
36VDR_23849224_ChIP-Seq_CD4+_Human1.46829543
37UTX_26944678_Chip-Seq_JUKART_Human1.45735573
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.45550879
39P68_20966046_ChIP-Seq_HELA_Human1.45422046
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.45262682
41DCP1A_22483619_ChIP-Seq_HELA_Human1.41020310
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40756727
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.40441628
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39668052
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39149779
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37158077
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36552669
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35872681
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35689110
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34881021
51* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34560765
52CIITA_25753668_ChIP-Seq_RAJI_Human1.33937263
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33585788
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.33315790
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31878061
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.31874506
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30865859
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30654999
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30571985
60AR_21909140_ChIP-Seq_LNCAP_Human1.28467649
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27719605
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27719605
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27719605
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27714879
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27179651
66KDM2B_26808549_Chip-Seq_DND41_Human1.26955438
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26778945
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26452964
69ATF3_27146783_Chip-Seq_COLON_Human1.26019184
70KDM2B_26808549_Chip-Seq_K562_Human1.26010980
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24986654
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24495412
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24040163
74ZNF263_19887448_ChIP-Seq_K562_Human1.23200069
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23067731
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22629796
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22554730
78MYB_26560356_Chip-Seq_TH2_Human1.22402800
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21359958
80FOXP3_21729870_ChIP-Seq_TREG_Human1.21238119
81VDR_24763502_ChIP-Seq_THP-1_Human1.21181225
82TFEB_21752829_ChIP-Seq_HELA_Human1.20800814
83GABP_19822575_ChIP-Seq_HepG2_Human1.20418852
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20361797
85* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19508279
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19112530
87MAF_26560356_Chip-Seq_TH2_Human1.18775818
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18627794
89TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16378145
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16236050
91SPI1_23547873_ChIP-Seq_NB4_Human1.16178544
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16043976
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15614571
94CREB1_26743006_Chip-Seq_LNCaP_Human1.15464150
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15406287
96EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15153198
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.14629196
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14625702
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14455834
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13068512
101MYB_26560356_Chip-Seq_TH1_Human1.12936039
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.12266605
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11865110
104KDM5A_27292631_Chip-Seq_BREAST_Human1.11646273
105JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11152149
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10313626
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10304975
108SMC4_20622854_ChIP-Seq_HELA_Human1.09883126
109KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09882753
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09442875
111P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09436895
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09411848
113ELK1_19687146_ChIP-ChIP_HELA_Human1.08677617
114CTCF_26484167_Chip-Seq_Bcells_Mouse1.06865253
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06767655
116CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06541737
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06304998
118BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05972885
119* RUNX1_22412390_ChIP-Seq_EML_Mouse1.05935995
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05704566
121CLOCK_20551151_ChIP-Seq_293T_Human1.05462649
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04897851
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04897846
124NOTCH1_21737748_ChIP-Seq_TLL_Human1.04761245
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03989762
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03886483
127BCOR_27268052_Chip-Seq_Bcells_Human1.03657233
128STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03652104
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03334214
130BCL6_27268052_Chip-Seq_Bcells_Human1.03236481
131* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02381157
132* RACK7_27058665_Chip-Seq_MCF-7_Human1.02178956
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01852965
134PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00905940
135STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00363802
136NCOR1_26117541_ChIP-Seq_K562_Human1.00355005
137ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99889168
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99432965
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98846866
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98182071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.81057965
2MP0010352_gastrointestinal_tract_polyps3.30520849
3MP0003693_abnormal_embryo_hatching2.98101699
4MP0004957_abnormal_blastocyst_morpholog2.94291196
5MP0005058_abnormal_lysosome_morphology2.59348162
6MP0003705_abnormal_hypodermis_morpholog2.39340883
7MP0003111_abnormal_nucleus_morphology2.38022909
8MP0005076_abnormal_cell_differentiation2.34064656
9MP0003077_abnormal_cell_cycle2.31005490
10MP0004858_abnormal_nervous_system2.26634936
11MP0010094_abnormal_chromosome_stability2.19890421
12MP0000678_abnormal_parathyroid_gland2.16900853
13MP0004233_abnormal_muscle_weight2.15995962
14MP0002396_abnormal_hematopoietic_system2.14546897
15MP0008057_abnormal_DNA_replication2.13056017
16MP0002877_abnormal_melanocyte_morpholog2.10017869
17MP0008260_abnormal_autophagy1.96194002
18MP0000685_abnormal_immune_system1.90587561
19MP0000490_abnormal_crypts_of1.88275245
20MP0003763_abnormal_thymus_physiology1.86508356
21MP0008438_abnormal_cutaneous_collagen1.84880307
22MP0000350_abnormal_cell_proliferation1.82790866
23MP0003300_gastrointestinal_ulcer1.81319499
24MP0003566_abnormal_cell_adhesion1.81044868
25MP0003303_peritoneal_inflammation1.74360651
26MP0004510_myositis1.73264178
27MP0004808_abnormal_hematopoietic_stem1.70162749
28MP0008007_abnormal_cellular_replicative1.68825932
29MP0009840_abnormal_foam_cell1.68357293
30MP0009333_abnormal_splenocyte_physiolog1.63640810
31MP0009278_abnormal_bone_marrow1.57939245
32MP0005666_abnormal_adipose_tissue1.56747817
33MP0008932_abnormal_embryonic_tissue1.54359693
34MP0005464_abnormal_platelet_physiology1.54110915
35MP0002249_abnormal_larynx_morphology1.52441395
36MP0010030_abnormal_orbit_morphology1.49522512
37MP0001730_embryonic_growth_arrest1.48860838
38MP0000703_abnormal_thymus_morphology1.45964140
39MP0002398_abnormal_bone_marrow1.45536420
40MP0010307_abnormal_tumor_latency1.45043045
41MP0001348_abnormal_lacrimal_gland1.41965771
42MP0000858_altered_metastatic_potential1.41277133
43MP0005023_abnormal_wound_healing1.40289405
44MP0001545_abnormal_hematopoietic_system1.37857844
45MP0005397_hematopoietic_system_phenotyp1.37857844
46MP0000733_abnormal_muscle_development1.37280104
47MP0005380_embryogenesis_phenotype1.34831800
48MP0001672_abnormal_embryogenesis/_devel1.34831800
49MP0001800_abnormal_humoral_immune1.33232615
50MP0002019_abnormal_tumor_incidence1.31746934
51MP0001697_abnormal_embryo_size1.31538206
52MP0003878_abnormal_ear_physiology1.30569712
53MP0005377_hearing/vestibular/ear_phenot1.30569712
54MP0003984_embryonic_growth_retardation1.29263918
55MP0002722_abnormal_immune_system1.29182289
56MP0002088_abnormal_embryonic_growth/wei1.28945908
57MP0004197_abnormal_fetal_growth/weight/1.28839826
58MP0002086_abnormal_extraembryonic_tissu1.26966632
59MP0005375_adipose_tissue_phenotype1.26562330
60MP0009053_abnormal_anal_canal1.25840567
61MP0004947_skin_inflammation1.24097859
62MP0001849_ear_inflammation1.22950634
63MP0000750_abnormal_muscle_regeneration1.22592651
64MP0003436_decreased_susceptibility_to1.21916384
65MP0002085_abnormal_embryonic_tissue1.21779444
66MP0002405_respiratory_system_inflammati1.21709497
67MP0002084_abnormal_developmental_patter1.21017714
68MP0002080_prenatal_lethality1.20730031
69MP0001727_abnormal_embryo_implantation1.20603313
70MP0003567_abnormal_fetal_cardiomyocyte1.19983479
71MP0000689_abnormal_spleen_morphology1.16789365
72MP0002452_abnormal_antigen_presenting1.16751042
73MP0003123_paternal_imprinting1.16292484
74MP0005387_immune_system_phenotype1.14385570
75MP0001790_abnormal_immune_system1.14385570
76MP0002166_altered_tumor_susceptibility1.14206510
77MP0003448_altered_tumor_morphology1.11209554
78MP0000537_abnormal_urethra_morphology1.10847549
79* MP0000759_abnormal_skeletal_muscle1.10354597
80MP0000716_abnormal_immune_system1.09733542
81MP0002420_abnormal_adaptive_immunity1.09608814
82MP0005000_abnormal_immune_tolerance1.09353241
83MP0001819_abnormal_immune_cell1.08976958
84MP0009672_abnormal_birth_weight1.08565968
85MP0001835_abnormal_antigen_presentation1.05679958
86MP0002429_abnormal_blood_cell1.05639500
87MP0002006_tumorigenesis1.05421917
88MP0000313_abnormal_cell_death1.05136850
89MP0003453_abnormal_keratinocyte_physiol1.03470609
90MP0002723_abnormal_immune_serum1.02673336
91MP0010155_abnormal_intestine_physiology1.00768387
92MP0000747_muscle_weakness0.99573475
93MP0000751_myopathy0.98156284
94MP0000681_abnormal_thyroid_gland0.97214177
95MP0003191_abnormal_cellular_cholesterol0.97131110
96MP0002089_abnormal_postnatal_growth/wei0.96758938
97MP0006054_spinal_hemorrhage0.96734711
98MP0003879_abnormal_hair_cell0.95955088
99MP0003091_abnormal_cell_migration0.95780829
100MP0002163_abnormal_gland_morphology0.95627128
101MP0005671_abnormal_response_to0.95303895
102MP0000343_altered_response_to0.95175648
103MP0000003_abnormal_adipose_tissue0.94461268
104MP0002060_abnormal_skin_morphology0.92928535
105MP0000428_abnormal_craniofacial_morphol0.88020546
106MP0010234_abnormal_vibrissa_follicle0.87536042
107MP0005025_abnormal_response_to0.87448851
108MP0001853_heart_inflammation0.87106159
109MP0009931_abnormal_skin_appearance0.86705609
110MP0003828_pulmonary_edema0.86211874
111MP0003119_abnormal_digestive_system0.85523418
112MP0000477_abnormal_intestine_morphology0.85218302
113MP0001293_anophthalmia0.84275797
114MP0004185_abnormal_adipocyte_glucose0.83563266
115MP0003075_altered_response_to0.83371953
116MP0001533_abnormal_skeleton_physiology0.83188824
117* MP0004087_abnormal_muscle_fiber0.83074981
118MP0002998_abnormal_bone_remodeling0.82715953
119MP0005330_cardiomyopathy0.82690379
120MP0002148_abnormal_hypersensitivity_rea0.81590937
121MP0009785_altered_susceptibility_to0.81487417
122MP0005623_abnormal_meninges_morphology0.80337276
123MP0005501_abnormal_skin_physiology0.79359011
124MP0001873_stomach_inflammation0.79313730
125MP0005621_abnormal_cell_physiology0.78322205
126MP0003656_abnormal_erythrocyte_physiolo0.77912881
127MP0003279_aneurysm0.77668741
128MP0001881_abnormal_mammary_gland0.77137373
129MP0002925_abnormal_cardiovascular_devel0.76773754
130MP0001216_abnormal_epidermal_layer0.76759066
131MP0002419_abnormal_innate_immunity0.76284063
132* MP0010630_abnormal_cardiac_muscle0.74759091
133MP0005390_skeleton_phenotype0.74267020
134MP0003221_abnormal_cardiomyocyte_apopto0.73329313
135MP0002796_impaired_skin_barrier0.73308220
136MP0003941_abnormal_skin_development0.73230441
137MP0005257_abnormal_intraocular_pressure0.72664868
138MP0003172_abnormal_lysosome_physiology0.72351244
139MP0002092_abnormal_eye_morphology0.72283574
140MP0008058_abnormal_DNA_repair0.71950579
141MP0002932_abnormal_joint_morphology0.71699885
142MP0004264_abnormal_extraembryonic_tissu0.70102086
143MP0003786_premature_aging0.68116784
144MP0003866_abnormal_defecation0.67917975

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.26758112
2Abnormality of cells of the erythroid lineage (HP:0012130)4.09237220
3Abnormal number of erythroid precursors (HP:0012131)3.62614178
4Increased density of long bones (HP:0006392)3.52028126
5Pallor (HP:0000980)3.09515243
6Cholecystitis (HP:0001082)3.02057031
7Abnormal gallbladder physiology (HP:0012438)3.02057031
8Myopathic facies (HP:0002058)3.01203309
9Protrusio acetabuli (HP:0003179)2.94496863
10Centrally nucleated skeletal muscle fibers (HP:0003687)2.93863963
11Selective tooth agenesis (HP:0001592)2.83838775
12Distal lower limb amyotrophy (HP:0008944)2.83284776
13Progressive muscle weakness (HP:0003323)2.80464273
14Distal lower limb muscle weakness (HP:0009053)2.79026975
15Abnormality of the nasal mucosa (HP:0000433)2.75939768
16Macrocytic anemia (HP:0001972)2.75910962
17Thrombocytosis (HP:0001894)2.74155471
18Increased connective tissue (HP:0009025)2.67938291
19Reduced subcutaneous adipose tissue (HP:0003758)2.61742270
20Hypertensive crisis (HP:0100735)2.60074087
21Multiple enchondromatosis (HP:0005701)2.56745182
22Broad distal phalanx of finger (HP:0009836)2.52568268
23Ragged-red muscle fibers (HP:0003200)2.52110346
24Trismus (HP:0000211)2.43877343
25Abnormal hemoglobin (HP:0011902)2.41519378
26Hyperthyroidism (HP:0000836)2.39972394
27Stridor (HP:0010307)2.35691762
28* Achilles tendon contracture (HP:0001771)2.35630642
29Truncus arteriosus (HP:0001660)2.34602337
30Elevated erythrocyte sedimentation rate (HP:0003565)2.34335088
31Patellar dislocation (HP:0002999)2.33242997
32Axonal loss (HP:0003447)2.33190209
33Abnormality of the fingertips (HP:0001211)2.30969438
34Reticulocytosis (HP:0001923)2.29471809
35Long palpebral fissure (HP:0000637)2.29452110
36IgM deficiency (HP:0002850)2.27311638
37Hyperparathyroidism (HP:0000843)2.27078579
38Colon cancer (HP:0003003)2.25764537
39Ependymoma (HP:0002888)2.24255602
40Myositis (HP:0100614)2.23103004
41Basal cell carcinoma (HP:0002671)2.22260151
42Abnormality of skeletal muscle fiber size (HP:0012084)2.20775277
43Abnormal number of incisors (HP:0011064)2.20502524
44Rectal prolapse (HP:0002035)2.15480854
45Persistence of primary teeth (HP:0006335)2.14350222
46Rhabdomyosarcoma (HP:0002859)2.13944115
47Increased variability in muscle fiber diameter (HP:0003557)2.13900060
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13320748
49Deviation of the thumb (HP:0009603)2.12128962
50Missing ribs (HP:0000921)2.11392343
51Disproportionate tall stature (HP:0001519)2.11044355
52Large eyes (HP:0001090)2.10697964
53Proximal placement of thumb (HP:0009623)2.09961945
54Atresia of the external auditory canal (HP:0000413)2.09532865
55Abnormality of the tricuspid valve (HP:0001702)2.08896036
56Shallow orbits (HP:0000586)2.07238812
57Insomnia (HP:0100785)2.05777358
58Biconcave vertebral bodies (HP:0004586)2.04836806
59Spinal rigidity (HP:0003306)2.03505123
60Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03004018
61Short 4th metacarpal (HP:0010044)2.03004018
62Hypertriglyceridemia (HP:0002155)2.02781344
63Distal upper limb amyotrophy (HP:0007149)2.01909351
64Upper limb amyotrophy (HP:0009129)2.01909351
65Genu recurvatum (HP:0002816)2.01608526
66Abnormality of the umbilical cord (HP:0010881)2.01268667
67Cellulitis (HP:0100658)2.01063115
68Increased serum ferritin (HP:0003281)2.00827929
69* Abnormality of the Achilles tendon (HP:0005109)1.99874233
70Ulnar bowing (HP:0003031)1.97660332
71Emphysema (HP:0002097)1.96593358
72Premature skin wrinkling (HP:0100678)1.94619323
73Abnormality of the distal phalanges of the toes (HP:0010182)1.94279543
74Cholelithiasis (HP:0001081)1.93120917
75Ankle contracture (HP:0006466)1.92417980
76Atelectasis (HP:0100750)1.91667570
77Long toe (HP:0010511)1.90874270
78* Elbow flexion contracture (HP:0002987)1.90020397
79Generalized amyotrophy (HP:0003700)1.89433813
80Increased cerebral lipofuscin (HP:0011813)1.88848875
81Oral leukoplakia (HP:0002745)1.87728500
82Orchitis (HP:0100796)1.86221091
83Bulbar palsy (HP:0001283)1.85766711
84Lower limb amyotrophy (HP:0007210)1.84715665
85Preauricular skin tag (HP:0000384)1.84713350
86Fused cervical vertebrae (HP:0002949)1.83926261
87Bicuspid aortic valve (HP:0001647)1.83541491
88Hypercortisolism (HP:0001578)1.83377220
89Seborrheic dermatitis (HP:0001051)1.83185387
90Petechiae (HP:0000967)1.83033702
91Segmental peripheral demyelination/remyelination (HP:0003481)1.82206666
92Testicular atrophy (HP:0000029)1.82093370
93Self-mutilation (HP:0000742)1.81867090
94Aplastic anemia (HP:0001915)1.81805552
95Mitral regurgitation (HP:0001653)1.81772349
96Abnormal large intestine physiology (HP:0012700)1.80692414
97Unilateral renal agenesis (HP:0000122)1.80652834
98Neoplasm of striated muscle (HP:0009728)1.80157151
99Skin tags (HP:0010609)1.79924327
100Increased nuchal translucency (HP:0010880)1.79271792
101Fragile skin (HP:0001030)1.78807558
102Patellar aplasia (HP:0006443)1.78433498
103Radial bowing (HP:0002986)1.78359388
104Obstructive sleep apnea (HP:0002870)1.78033841
105Recurrent bronchitis (HP:0002837)1.77921602
106Rib fusion (HP:0000902)1.77717735
107Easy fatigability (HP:0003388)1.77185969
108Broad face (HP:0000283)1.77131751
109Cervical subluxation (HP:0003308)1.76889640
110Breast hypoplasia (HP:0003187)1.75639383
111Cerebral aneurysm (HP:0004944)1.75145074
112Exercise-induced myalgia (HP:0003738)1.74811698
113Interstitial pulmonary disease (HP:0006530)1.74796855
114Bowel incontinence (HP:0002607)1.74695142
115Fatigue (HP:0012378)1.74678285
116Premature rupture of membranes (HP:0001788)1.73532688
117Difficulty climbing stairs (HP:0003551)1.72217566
118Type 1 muscle fiber predominance (HP:0003803)1.72141249
119Hyperacusis (HP:0010780)1.71486770
120Increased neuronal autofluorescent lipopigment (HP:0002074)1.70866321
121Amaurosis fugax (HP:0100576)1.70182712
122Flexion contracture of toe (HP:0005830)1.70034158
123Joint contractures involving the joints of the feet (HP:0100492)1.70034158
124Aplasia/Hypoplasia of the patella (HP:0006498)1.69689997
125Nuclear cataract (HP:0100018)1.68600541
126Angiofibromas (HP:0010615)1.68477843
127Adenoma sebaceum (HP:0009720)1.68477843
128Neoplasm of the pancreas (HP:0002894)1.68188265
129Peritonitis (HP:0002586)1.68146383
130Recurrent viral infections (HP:0004429)1.68142166
131Hypoparathyroidism (HP:0000829)1.67774416
132Overlapping toe (HP:0001845)1.67663990
133Purpura (HP:0000979)1.67512634
134Flat capital femoral epiphysis (HP:0003370)1.67046640
135Lymphoma (HP:0002665)1.67007134
136Thick lower lip vermilion (HP:0000179)1.66497658
137Abnormality of the calcaneus (HP:0008364)1.65787395
138Abnormality of reticulocytes (HP:0004312)1.65218128
139Septate vagina (HP:0001153)1.64432791
140Abnormality of the phalanges of the hallux (HP:0010057)1.64386737
141Polygenic inheritance (HP:0010982)1.64080553
142Malignant gastrointestinal tract tumors (HP:0006749)1.64058815
143Gastrointestinal carcinoma (HP:0002672)1.64058815
144Rough bone trabeculation (HP:0100670)1.63829675
145Back pain (HP:0003418)1.62668505
146Vertebral hypoplasia (HP:0008417)1.62398714
147Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.62398714
148Autoimmune hemolytic anemia (HP:0001890)1.62083624
149Abnormality of glycolipid metabolism (HP:0010969)1.62050138
150Abnormality of liposaccharide metabolism (HP:0010968)1.62050138
151Abnormality of glycosphingolipid metabolism (HP:0004343)1.62050138
152Bowed forearm bones (HP:0003956)1.61846494
153Bowing of the arm (HP:0006488)1.61846494
154Medulloblastoma (HP:0002885)1.61784085
155Calcaneovalgus deformity (HP:0001848)1.61651874
156Bone pain (HP:0002653)1.61026179
157Ectopia lentis (HP:0001083)1.61015946
158Chronic otitis media (HP:0000389)1.59893002
159Abnormal platelet volume (HP:0011876)1.59418727
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.59413320
161Osteolytic defects of the hand bones (HP:0009699)1.59413320
162Abnormality of T cell physiology (HP:0011840)1.58129643
163Nasal polyposis (HP:0100582)1.57773931
164Abnormality of T cells (HP:0002843)1.56854524
165Renal duplication (HP:0000075)1.56685773
166Carpal bone hypoplasia (HP:0001498)1.56634406
167Vertebral compression fractures (HP:0002953)1.55898175
168Abnormality of the 4th metacarpal (HP:0010012)1.54950432
169Concave nail (HP:0001598)1.54728046
170Verrucae (HP:0200043)1.54055530
171Papilloma (HP:0012740)1.54055530
172Abnormality of the peritoneum (HP:0002585)1.53252914
17311 pairs of ribs (HP:0000878)1.53205899
174Facial hemangioma (HP:0000329)1.52796400
175Squamous cell carcinoma (HP:0002860)1.52686412
176Volvulus (HP:0002580)1.52507217
177Dilatation of the ascending aorta (HP:0005111)1.52313826
178Absent thumb (HP:0009777)1.51868352
179Recurrent fungal infections (HP:0002841)1.51023097
180Blepharitis (HP:0000498)1.50497832
181Astrocytoma (HP:0009592)1.50466054
182Abnormality of the astrocytes (HP:0100707)1.50466054
183Myelodysplasia (HP:0002863)1.50200215
184Broad palm (HP:0001169)1.49928797
185Supernumerary ribs (HP:0005815)1.49284625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.80667019
2SMG13.65009277
3EEF2K3.16472001
4PRPF4B3.15981600
5TRIB33.09223142
6MAP3K103.00066243
7NME22.88014156
8CDK122.83193270
9PKN22.41041531
10TAOK22.40792347
11SIK12.39418402
12VRK22.36127286
13MAP4K12.32896870
14RPS6KB22.21628981
15STK102.09442900
16LRRK22.09289599
17CDC72.03128198
18ERN12.02728123
19NEK21.90132378
20RPS6KA41.86311099
21MOS1.85317890
22TLK11.80346554
23PIM21.78004958
24WEE11.76706938
25ARAF1.76056331
26CDK41.66384428
27TTN1.60119390
28CDK71.48030097
29EPHA21.46900737
30PAK41.45746997
31PASK1.41253671
32BUB11.40271295
33ALK1.33729312
34CDK61.32631952
35TESK21.28443064
36GRK61.25183595
37BMX1.20440211
38MAP3K81.20300880
39TGFBR11.15713422
40PIM11.10981533
41TSSK61.09730802
42MAP2K31.09288393
43BRAF1.08064429
44TYK21.07649471
45MAPKAPK31.07055564
46DYRK31.06819455
47ILK1.04554429
48FLT31.04092371
49RIPK11.03521715
50IRAK41.03335005
51NEK11.03251940
52IRAK21.03083260
53AURKB1.01919432
54BTK1.00489595
55TTK0.96257704
56KSR20.96135938
57TBK10.95989535
58PAK20.91864853
59PTK20.91583278
60CSF1R0.89580138
61MAP3K10.88382100
62TAOK10.86988102
63PRKD30.86961228
64PDGFRA0.86849180
65PTK60.86356777
66PLK10.83984810
67ZAP700.83930353
68SCYL20.83884596
69ACVR1B0.81345262
70IKBKB0.80194490
71AURKA0.78514084
72MTOR0.78460323
73BRD40.78421212
74MAP3K110.76671637
75CHUK0.75958547
76JAK30.75808091
77MATK0.75168523
78TESK10.72917202
79RIPK40.72288032
80SIK30.71880828
81GRK70.71832594
82DMPK0.70481648
83MAPKAPK20.70217712
84EIF2AK10.68871924
85CHEK10.67855226
86KIT0.67535233
87BRSK20.67073653
88CLK10.67011760
89HIPK20.64786652
90ATR0.63731285
91LATS20.63494775
92CHEK20.63103082
93EPHB10.62306805
94RPS6KA20.62027588
95MAP3K30.61101270
96DYRK1B0.61052345
97MAPK110.60863157
98PDPK10.60034922
99STK30.59859565
100ITK0.59779562
101MAP3K130.59186927
102PAK10.59137211
103DAPK30.59118613
104RAF10.58084100
105CDK20.56715567
106CSK0.56639924
107RPS6KA10.56530914
108KDR0.55916708
109BCKDK0.55059194
110VRK10.54273928
111LIMK10.54065966
112RPS6KL10.53598284
113RPS6KC10.53598284
114RPS6KA60.53314360
115SRPK10.52925169
116TAF10.52919088
117MARK20.51050526
118AKT20.49799467
119DDR20.49575712
120LCK0.49341800
121MKNK10.48982778
122STK160.48796367
123PRKG20.48771217
124ICK0.48339423
125EPHB20.47417586
126STK40.46529557
127GRK50.46155373
128DAPK10.45704001
129CDK90.45537293
130CDK11A0.45387216
131CDC42BPA0.45373577
132PBK0.44994029
133ABL20.44993157
134NEK90.43209529
135TGFBR20.42861196
136MAP2K20.42020722
137MAP3K140.41923464
138NLK0.41084956
139SYK0.40895390
140CDK80.39723232
141CDK150.39497206
142CDK140.39398339
143LMTK20.39274546
144FGFR40.38383708
145PRKD20.38167137
146NME10.37881467

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.27833379
2DNA replication_Homo sapiens_hsa030303.51484419
3Spliceosome_Homo sapiens_hsa030402.58998640
4Mismatch repair_Homo sapiens_hsa034302.47208920
5Pentose phosphate pathway_Homo sapiens_hsa000302.26680326
6RNA transport_Homo sapiens_hsa030132.15660838
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04375280
8Biosynthesis of amino acids_Homo sapiens_hsa012302.04132865
9Cell cycle_Homo sapiens_hsa041102.03826214
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03178697
11Base excision repair_Homo sapiens_hsa034101.97341739
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95270430
13Prion diseases_Homo sapiens_hsa050201.75174470
14p53 signaling pathway_Homo sapiens_hsa041151.73980994
15Nucleotide excision repair_Homo sapiens_hsa034201.70902705
16Fructose and mannose metabolism_Homo sapiens_hsa000511.70254778
17Homologous recombination_Homo sapiens_hsa034401.69964111
18One carbon pool by folate_Homo sapiens_hsa006701.61287173
19Other glycan degradation_Homo sapiens_hsa005111.61052146
20Antigen processing and presentation_Homo sapiens_hsa046121.52840386
21Primary immunodeficiency_Homo sapiens_hsa053401.50802020
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49059377
23Chronic myeloid leukemia_Homo sapiens_hsa052201.47466073
24Bladder cancer_Homo sapiens_hsa052191.44565489
25RNA polymerase_Homo sapiens_hsa030201.41735265
26HTLV-I infection_Homo sapiens_hsa051661.39736731
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39051141
28Galactose metabolism_Homo sapiens_hsa000521.36085016
29Small cell lung cancer_Homo sapiens_hsa052221.35708469
30Herpes simplex infection_Homo sapiens_hsa051681.33045625
31mRNA surveillance pathway_Homo sapiens_hsa030151.30153372
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26659225
33Leishmaniasis_Homo sapiens_hsa051401.26048883
34Pyrimidine metabolism_Homo sapiens_hsa002401.25281358
35Epstein-Barr virus infection_Homo sapiens_hsa051691.24663281
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.24381931
37Carbon metabolism_Homo sapiens_hsa012001.22963607
38Proteasome_Homo sapiens_hsa030501.21966286
39Acute myeloid leukemia_Homo sapiens_hsa052211.21573118
40MicroRNAs in cancer_Homo sapiens_hsa052061.21504994
41Viral myocarditis_Homo sapiens_hsa054161.21479054
42Shigellosis_Homo sapiens_hsa051311.21076690
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20826758
44Viral carcinogenesis_Homo sapiens_hsa052031.20668371
45Measles_Homo sapiens_hsa051621.16188082
46Thyroid cancer_Homo sapiens_hsa052161.13098046
47Hepatitis B_Homo sapiens_hsa051611.12255653
48Apoptosis_Homo sapiens_hsa042101.11688176
49B cell receptor signaling pathway_Homo sapiens_hsa046621.09979433
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06340560
51Colorectal cancer_Homo sapiens_hsa052101.05603020
52RNA degradation_Homo sapiens_hsa030181.03472300
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03360494
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03268352
55Legionellosis_Homo sapiens_hsa051341.02274170
56Notch signaling pathway_Homo sapiens_hsa043301.01687007
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01391487
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00276093
59Insulin signaling pathway_Homo sapiens_hsa049100.99760759
60Osteoclast differentiation_Homo sapiens_hsa043800.99464036
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99461055
62Adherens junction_Homo sapiens_hsa045200.96451269
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.95630592
64Vibrio cholerae infection_Homo sapiens_hsa051100.95094249
65Proteoglycans in cancer_Homo sapiens_hsa052050.95074183
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.94443252
67T cell receptor signaling pathway_Homo sapiens_hsa046600.93753611
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92979227
69Toxoplasmosis_Homo sapiens_hsa051450.91535953
70Hematopoietic cell lineage_Homo sapiens_hsa046400.91425590
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91108841
72Glioma_Homo sapiens_hsa052140.87535423
73Pancreatic cancer_Homo sapiens_hsa052120.87479530
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86604218
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86481149
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.86472050
77Fanconi anemia pathway_Homo sapiens_hsa034600.86228009
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84443922
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84317882
80Non-small cell lung cancer_Homo sapiens_hsa052230.83902088
81TNF signaling pathway_Homo sapiens_hsa046680.83881385
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83201524
83Hippo signaling pathway_Homo sapiens_hsa043900.82493483
84Endocytosis_Homo sapiens_hsa041440.79284964
85mTOR signaling pathway_Homo sapiens_hsa041500.77918128
86Hepatitis C_Homo sapiens_hsa051600.76750155
87VEGF signaling pathway_Homo sapiens_hsa043700.76679564
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76307451
89Pathways in cancer_Homo sapiens_hsa052000.73373759
90Basal cell carcinoma_Homo sapiens_hsa052170.73336859
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73265097
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73132127
93AMPK signaling pathway_Homo sapiens_hsa041520.71432285
94Influenza A_Homo sapiens_hsa051640.70612946
95Platelet activation_Homo sapiens_hsa046110.70482024
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70133137
97TGF-beta signaling pathway_Homo sapiens_hsa043500.70070531
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.69842206
99N-Glycan biosynthesis_Homo sapiens_hsa005100.69342586
100HIF-1 signaling pathway_Homo sapiens_hsa040660.69245205
101ErbB signaling pathway_Homo sapiens_hsa040120.69169397
102Non-homologous end-joining_Homo sapiens_hsa034500.67851287
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67705965
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.67365048
105Focal adhesion_Homo sapiens_hsa045100.66729355
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66580606
107Allograft rejection_Homo sapiens_hsa053300.65449596
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65187726
109Graft-versus-host disease_Homo sapiens_hsa053320.63752406
110Amoebiasis_Homo sapiens_hsa051460.63704270
111Lysosome_Homo sapiens_hsa041420.62054357
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60269219
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60054265
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.59849746
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59809619
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59355086
117Prostate cancer_Homo sapiens_hsa052150.57802207
118Renal cell carcinoma_Homo sapiens_hsa052110.57551013
119Sulfur relay system_Homo sapiens_hsa041220.56193288
120Basal transcription factors_Homo sapiens_hsa030220.55882120
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.55731231
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55209400
123Prolactin signaling pathway_Homo sapiens_hsa049170.53794660
124Arginine and proline metabolism_Homo sapiens_hsa003300.53061893
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.52565028
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51262951
127Endometrial cancer_Homo sapiens_hsa052130.49844526
128Salmonella infection_Homo sapiens_hsa051320.49362663
129Melanoma_Homo sapiens_hsa052180.49114271
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48098851
131Oocyte meiosis_Homo sapiens_hsa041140.48072801
132Tuberculosis_Homo sapiens_hsa051520.47468023
133Malaria_Homo sapiens_hsa051440.45979712
134Systemic lupus erythematosus_Homo sapiens_hsa053220.45498669
135Hedgehog signaling pathway_Homo sapiens_hsa043400.44672742

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