

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.90821577 |
| 2 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.85116022 |
| 3 | viral transcription (GO:0019083) | 4.68851660 |
| 4 | DNA strand elongation (GO:0022616) | 4.65671594 |
| 5 | DNA replication checkpoint (GO:0000076) | 4.64176732 |
| 6 | translational termination (GO:0006415) | 4.54961914 |
| 7 | DNA replication initiation (GO:0006270) | 4.46774937 |
| 8 | maturation of SSU-rRNA (GO:0030490) | 4.46690614 |
| 9 | protein localization to kinetochore (GO:0034501) | 4.40298155 |
| 10 | kinetochore organization (GO:0051383) | 4.37464000 |
| 11 | mitotic metaphase plate congression (GO:0007080) | 4.36951297 |
| 12 | telomere maintenance via recombination (GO:0000722) | 4.36326011 |
| 13 | ribosomal large subunit biogenesis (GO:0042273) | 4.34262017 |
| 14 | mitotic recombination (GO:0006312) | 4.29170397 |
| 15 | kinetochore assembly (GO:0051382) | 4.18438990 |
| 16 | DNA unwinding involved in DNA replication (GO:0006268) | 4.18150836 |
| 17 | DNA deamination (GO:0045006) | 4.12947585 |
| 18 | telomere maintenance via telomere lengthening (GO:0010833) | 4.05921867 |
| 19 | mitotic sister chromatid segregation (GO:0000070) | 4.04615734 |
| 20 | translational elongation (GO:0006414) | 4.01752988 |
| 21 | ribosomal small subunit assembly (GO:0000028) | 4.01676020 |
| 22 | ribosomal small subunit biogenesis (GO:0042274) | 3.99908467 |
| 23 | chromatin remodeling at centromere (GO:0031055) | 3.95344889 |
| 24 | CENP-A containing nucleosome assembly (GO:0034080) | 3.94859863 |
| 25 | translational initiation (GO:0006413) | 3.93994323 |
| 26 | protein localization to chromosome, centromeric region (GO:0071459) | 3.92401238 |
| 27 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.86540237 |
| 28 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.79902448 |
| 29 | spliceosomal snRNP assembly (GO:0000387) | 3.78979921 |
| 30 | cotranslational protein targeting to membrane (GO:0006613) | 3.77774104 |
| 31 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.76531963 |
| 32 | protein targeting to ER (GO:0045047) | 3.75752824 |
| 33 | metaphase plate congression (GO:0051310) | 3.72942963 |
| 34 | formation of translation preinitiation complex (GO:0001731) | 3.70285575 |
| 35 | cellular protein complex disassembly (GO:0043624) | 3.66230984 |
| 36 | mitotic nuclear envelope disassembly (GO:0007077) | 3.65725923 |
| 37 | intra-S DNA damage checkpoint (GO:0031573) | 3.65202177 |
| 38 | DNA topological change (GO:0006265) | 3.62089323 |
| 39 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.61917038 |
| 40 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.60771243 |
| 41 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.60771243 |
| 42 | sister chromatid segregation (GO:0000819) | 3.59694027 |
| 43 | DNA strand renaturation (GO:0000733) | 3.58934256 |
| 44 | spliceosomal complex assembly (GO:0000245) | 3.58592841 |
| 45 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.56122538 |
| 46 | regulation of spindle organization (GO:0090224) | 3.56113473 |
| 47 | viral life cycle (GO:0019058) | 3.55831851 |
| 48 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.53996219 |
| 49 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.52554091 |
| 50 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.52060400 |
| 51 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.50411796 |
| 52 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.49988662 |
| 53 | DNA replication-independent nucleosome organization (GO:0034724) | 3.49988662 |
| 54 | nucleobase biosynthetic process (GO:0046112) | 3.49715406 |
| 55 | protein localization to endoplasmic reticulum (GO:0070972) | 3.48224125 |
| 56 | DNA ligation (GO:0006266) | 3.45301540 |
| 57 | establishment of chromosome localization (GO:0051303) | 3.44423003 |
| 58 | proteasome assembly (GO:0043248) | 3.41618296 |
| 59 | nuclear pore complex assembly (GO:0051292) | 3.41201549 |
| 60 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.39414223 |
| 61 | mitotic chromosome condensation (GO:0007076) | 3.37801641 |
| 62 | replication fork processing (GO:0031297) | 3.36773957 |
| 63 | regulation of mitochondrial translation (GO:0070129) | 3.34787377 |
| 64 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.34288853 |
| 65 | rRNA processing (GO:0006364) | 3.34017432 |
| 66 | nuclear envelope disassembly (GO:0051081) | 3.33501084 |
| 67 | membrane disassembly (GO:0030397) | 3.33501084 |
| 68 | protein complex disassembly (GO:0043241) | 3.32526228 |
| 69 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.32032966 |
| 70 | establishment of integrated proviral latency (GO:0075713) | 3.30920568 |
| 71 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.30872563 |
| 72 | protein K6-linked ubiquitination (GO:0085020) | 3.28960827 |
| 73 | regulation of translational fidelity (GO:0006450) | 3.28187818 |
| 74 | histone exchange (GO:0043486) | 3.27716702 |
| 75 | ribosome biogenesis (GO:0042254) | 3.25221059 |
| 76 | purine nucleobase biosynthetic process (GO:0009113) | 3.25206350 |
| 77 | rRNA modification (GO:0000154) | 3.23966833 |
| 78 | rRNA metabolic process (GO:0016072) | 3.23098603 |
| 79 | resolution of meiotic recombination intermediates (GO:0000712) | 3.21750082 |
| 80 | positive regulation of chromosome segregation (GO:0051984) | 3.21089325 |
| 81 | rRNA methylation (GO:0031167) | 3.20277782 |
| 82 | regulation of centriole replication (GO:0046599) | 3.20009858 |
| 83 | spindle checkpoint (GO:0031577) | 3.19786464 |
| 84 | negative regulation of chromosome segregation (GO:0051985) | 3.19681777 |
| 85 | IMP biosynthetic process (GO:0006188) | 3.18664524 |
| 86 | meiotic chromosome segregation (GO:0045132) | 3.17671608 |
| 87 | ATP synthesis coupled proton transport (GO:0015986) | 3.17548570 |
| 88 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.17548570 |
| 89 | macromolecular complex disassembly (GO:0032984) | 3.16576928 |
| 90 | viral mRNA export from host cell nucleus (GO:0046784) | 3.14816236 |
| 91 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.13742588 |
| 92 | base-excision repair (GO:0006284) | 3.12703255 |
| 93 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.11982781 |
| 94 | translation (GO:0006412) | 3.11953898 |
| 95 | regulation of mitotic spindle organization (GO:0060236) | 3.10676244 |
| 96 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.10247563 |
| 97 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.10247563 |
| 98 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.10247563 |
| 99 | negative regulation of sister chromatid segregation (GO:0033046) | 3.10247563 |
| 100 | chaperone-mediated protein transport (GO:0072321) | 3.09011802 |
| 101 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.08475833 |
| 102 | spindle assembly checkpoint (GO:0071173) | 3.08373048 |
| 103 | regulation of chromosome segregation (GO:0051983) | 3.06890968 |
| 104 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.05468089 |
| 105 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.05169051 |
| 106 | chromatin assembly or disassembly (GO:0006333) | 3.04536080 |
| 107 | mitotic spindle assembly checkpoint (GO:0007094) | 3.03869462 |
| 108 | L-serine metabolic process (GO:0006563) | 3.03477044 |
| 109 | cellular component biogenesis (GO:0044085) | 3.02839426 |
| 110 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.01480831 |
| 111 | regulation of DNA endoreduplication (GO:0032875) | 3.01195564 |
| 112 | heterochromatin organization (GO:0070828) | 3.01078405 |
| 113 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.01015795 |
| 114 | mitotic spindle checkpoint (GO:0071174) | 3.00823726 |
| 115 | nuclear pore organization (GO:0006999) | 2.99623713 |
| 116 | termination of RNA polymerase III transcription (GO:0006386) | 2.99551623 |
| 117 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.99551623 |
| 118 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.99371116 |
| 119 | mitotic sister chromatid cohesion (GO:0007064) | 2.98920442 |
| 120 | pseudouridine synthesis (GO:0001522) | 2.98839423 |
| 121 | mismatch repair (GO:0006298) | 2.97638065 |
| 122 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.96945073 |
| 123 | chromosome condensation (GO:0030261) | 2.96685104 |
| 124 | telomere organization (GO:0032200) | 2.96461919 |
| 125 | chromosome segregation (GO:0007059) | 2.95728231 |
| 126 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.92316097 |
| 127 | regulation of centrosome cycle (GO:0046605) | 2.87997993 |
| 128 | microtubule depolymerization (GO:0007019) | 2.87226231 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.79215408 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.96993443 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.41469351 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.95510801 |
| 5 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.66222509 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.46858678 |
| 7 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.41205243 |
| 8 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.17989591 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.01466814 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.91698310 |
| 11 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.90579115 |
| 12 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.88456367 |
| 13 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.83362255 |
| 14 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.80505109 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.71109263 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.69485401 |
| 17 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.44471899 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.39416689 |
| 19 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.37117530 |
| 20 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.31117928 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.27810143 |
| 22 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.24160828 |
| 23 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.11876522 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.07988838 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.07168410 |
| 26 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.04291022 |
| 27 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.00686227 |
| 28 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.97446458 |
| 29 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.92808930 |
| 30 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.90280077 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.90123494 |
| 32 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.88966158 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.88873382 |
| 34 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.87125473 |
| 35 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.83677554 |
| 36 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.82531515 |
| 37 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.80428208 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.80414068 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78845920 |
| 40 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.68119955 |
| 41 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.66687143 |
| 42 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.62816976 |
| 43 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.61445263 |
| 44 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.58206954 |
| 45 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.55456392 |
| 46 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.55059157 |
| 47 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.49124431 |
| 48 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.47235090 |
| 49 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.46778995 |
| 50 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.43583237 |
| 51 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.43031865 |
| 52 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.42701089 |
| 53 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.42665921 |
| 54 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.42524083 |
| 55 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.41408528 |
| 56 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37772415 |
| 57 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.37194944 |
| 58 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.35730242 |
| 59 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.35110643 |
| 60 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.28614854 |
| 61 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.26537763 |
| 62 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.24284823 |
| 63 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.23716059 |
| 64 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.20391625 |
| 65 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.20252444 |
| 66 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.19889024 |
| 67 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.18651459 |
| 68 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.16495980 |
| 69 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.16386632 |
| 70 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.15260341 |
| 71 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13626822 |
| 72 | MYC_22102868_ChIP-Seq_BL_Human | 1.11264380 |
| 73 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.10953848 |
| 74 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.10953848 |
| 75 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.10953848 |
| 76 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10832710 |
| 77 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.10418572 |
| 78 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.06011295 |
| 79 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05745038 |
| 80 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.04753519 |
| 81 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.04682927 |
| 82 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.01996879 |
| 83 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.01314872 |
| 84 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.01177785 |
| 85 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.98300723 |
| 86 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.97002212 |
| 87 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.95635416 |
| 88 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.95557715 |
| 89 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.94645280 |
| 90 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.93123895 |
| 91 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.91571150 |
| 92 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.91487249 |
| 93 | * ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.91478530 |
| 94 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.90485082 |
| 95 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.89784150 |
| 96 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.89664112 |
| 97 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.88890225 |
| 98 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.88414858 |
| 99 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.86288358 |
| 100 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.85820048 |
| 101 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.85714831 |
| 102 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.85082186 |
| 103 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.84546397 |
| 104 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.84391952 |
| 105 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.83885870 |
| 106 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.83811174 |
| 107 | * NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.82698941 |
| 108 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.81388488 |
| 109 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.80373227 |
| 110 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.78962281 |
| 111 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.78952076 |
| 112 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.77580885 |
| 113 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.76797992 |
| 114 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.75652710 |
| 115 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.74585061 |
| 116 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.74183103 |
| 117 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.73767971 |
| 118 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.73195150 |
| 119 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.68421772 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.61806153 |
| 2 | MP0003111_abnormal_nucleus_morphology | 4.69966697 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.59965265 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 4.37250946 |
| 5 | MP0003077_abnormal_cell_cycle | 4.12453858 |
| 6 | MP0008057_abnormal_DNA_replication | 3.88923667 |
| 7 | MP0008058_abnormal_DNA_repair | 3.55065820 |
| 8 | MP0008932_abnormal_embryonic_tissue | 3.17449593 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.78825642 |
| 10 | MP0000350_abnormal_cell_proliferation | 2.24682725 |
| 11 | MP0003123_paternal_imprinting | 2.22315741 |
| 12 | MP0001730_embryonic_growth_arrest | 2.20455410 |
| 13 | MP0010030_abnormal_orbit_morphology | 2.15007881 |
| 14 | MP0003786_premature_aging | 2.06172031 |
| 15 | MP0003806_abnormal_nucleotide_metabolis | 2.02029626 |
| 16 | MP0003718_maternal_effect | 2.00390533 |
| 17 | MP0006292_abnormal_olfactory_placode | 1.91016833 |
| 18 | MP0002396_abnormal_hematopoietic_system | 1.83414556 |
| 19 | MP0008877_abnormal_DNA_methylation | 1.83075380 |
| 20 | MP0004233_abnormal_muscle_weight | 1.76790842 |
| 21 | MP0003315_abnormal_perineum_morphology | 1.75450784 |
| 22 | MP0009379_abnormal_foot_pigmentation | 1.71153110 |
| 23 | MP0001697_abnormal_embryo_size | 1.65810825 |
| 24 | MP0005380_embryogenesis_phenotype | 1.65287068 |
| 25 | MP0001672_abnormal_embryogenesis/_devel | 1.65287068 |
| 26 | MP0002085_abnormal_embryonic_tissue | 1.63877417 |
| 27 | MP0000490_abnormal_crypts_of | 1.61416645 |
| 28 | MP0002163_abnormal_gland_morphology | 1.50892383 |
| 29 | MP0002080_prenatal_lethality | 1.50775409 |
| 30 | MP0001293_anophthalmia | 1.43698217 |
| 31 | MP0000313_abnormal_cell_death | 1.42088597 |
| 32 | MP0002234_abnormal_pharynx_morphology | 1.41478235 |
| 33 | MP0009697_abnormal_copulation | 1.41084398 |
| 34 | MP0002084_abnormal_developmental_patter | 1.39282034 |
| 35 | MP0002019_abnormal_tumor_incidence | 1.36893964 |
| 36 | MP0006035_abnormal_mitochondrial_morpho | 1.35483402 |
| 37 | MP0004133_heterotaxia | 1.35466535 |
| 38 | MP0003984_embryonic_growth_retardation | 1.34214724 |
| 39 | MP0002088_abnormal_embryonic_growth/wei | 1.33186455 |
| 40 | MP0006036_abnormal_mitochondrial_physio | 1.33003887 |
| 41 | MP0008995_early_reproductive_senescence | 1.32639886 |
| 42 | MP0003890_abnormal_embryonic-extraembry | 1.29907393 |
| 43 | MP0000566_synostosis | 1.26737395 |
| 44 | MP0010307_abnormal_tumor_latency | 1.26081086 |
| 45 | MP0000049_abnormal_middle_ear | 1.25069572 |
| 46 | MP0002653_abnormal_ependyma_morphology | 1.21054375 |
| 47 | MP0009333_abnormal_splenocyte_physiolog | 1.20300292 |
| 48 | MP0009053_abnormal_anal_canal | 1.20143772 |
| 49 | MP0002210_abnormal_sex_determination | 1.19729431 |
| 50 | MP0004197_abnormal_fetal_growth/weight/ | 1.19646855 |
| 51 | MP0003121_genomic_imprinting | 1.19150579 |
| 52 | MP0005076_abnormal_cell_differentiation | 1.18713970 |
| 53 | MP0002697_abnormal_eye_size | 1.18497007 |
| 54 | MP0002086_abnormal_extraembryonic_tissu | 1.18195828 |
| 55 | MP0003119_abnormal_digestive_system | 1.16170398 |
| 56 | MP0002102_abnormal_ear_morphology | 1.14622659 |
| 57 | MP0003567_abnormal_fetal_cardiomyocyte | 1.14427477 |
| 58 | MP0003941_abnormal_skin_development | 1.14167515 |
| 59 | MP0003937_abnormal_limbs/digits/tail_de | 1.14030825 |
| 60 | MP0003136_yellow_coat_color | 1.13883790 |
| 61 | MP0001346_abnormal_lacrimal_gland | 1.10239214 |
| 62 | MP0010352_gastrointestinal_tract_polyps | 1.06658027 |
| 63 | MP0002111_abnormal_tail_morphology | 1.05647630 |
| 64 | MP0001145_abnormal_male_reproductive | 1.03632863 |
| 65 | MP0000015_abnormal_ear_pigmentation | 1.02089151 |
| 66 | MP0005499_abnormal_olfactory_system | 1.01292937 |
| 67 | MP0005394_taste/olfaction_phenotype | 1.01292937 |
| 68 | MP0002160_abnormal_reproductive_system | 1.00680359 |
| 69 | MP0002233_abnormal_nose_morphology | 1.00538632 |
| 70 | MP0005257_abnormal_intraocular_pressure | 0.99124441 |
| 71 | MP0001529_abnormal_vocalization | 0.97568441 |
| 72 | MP0002938_white_spotting | 0.96877837 |
| 73 | MP0005084_abnormal_gallbladder_morpholo | 0.96866024 |
| 74 | MP0002751_abnormal_autonomic_nervous | 0.96582274 |
| 75 | MP0003938_abnormal_ear_development | 0.95505368 |
| 76 | MP0000428_abnormal_craniofacial_morphol | 0.94221417 |
| 77 | MP0005171_absent_coat_pigmentation | 0.93506439 |
| 78 | MP0005174_abnormal_tail_pigmentation | 0.92426800 |
| 79 | MP0005408_hypopigmentation | 0.92032092 |
| 80 | MP0000858_altered_metastatic_potential | 0.91801549 |
| 81 | MP0004808_abnormal_hematopoietic_stem | 0.90885887 |
| 82 | MP0001188_hyperpigmentation | 0.88310893 |
| 83 | MP0003186_abnormal_redox_activity | 0.86998895 |
| 84 | MP0000372_irregular_coat_pigmentation | 0.86666816 |
| 85 | MP0004147_increased_porphyrin_level | 0.86588424 |
| 86 | MP0001286_abnormal_eye_development | 0.86156975 |
| 87 | MP0005389_reproductive_system_phenotype | 0.86037338 |
| 88 | MP0000653_abnormal_sex_gland | 0.85131506 |
| 89 | MP0000537_abnormal_urethra_morphology | 0.83711904 |
| 90 | MP0000703_abnormal_thymus_morphology | 0.82543928 |
| 91 | MP0009672_abnormal_birth_weight | 0.82418410 |
| 92 | MP0009250_abnormal_appendicular_skeleto | 0.82401775 |
| 93 | MP0001929_abnormal_gametogenesis | 0.80200363 |
| 94 | MP0003755_abnormal_palate_morphology | 0.80091238 |
| 95 | MP0002249_abnormal_larynx_morphology | 0.78757082 |
| 96 | MP0006072_abnormal_retinal_apoptosis | 0.78422544 |
| 97 | MP0002132_abnormal_respiratory_system | 0.77858912 |
| 98 | MP0003698_abnormal_male_reproductive | 0.77576900 |
| 99 | MP0001119_abnormal_female_reproductive | 0.76525511 |
| 100 | MP0000613_abnormal_salivary_gland | 0.76359221 |
| 101 | MP0001919_abnormal_reproductive_system | 0.74882424 |
| 102 | MP0002177_abnormal_outer_ear | 0.74522482 |
| 103 | MP0001764_abnormal_homeostasis | 0.74457049 |
| 104 | MP0003942_abnormal_urinary_system | 0.74221732 |
| 105 | MP0000678_abnormal_parathyroid_gland | 0.74096916 |
| 106 | MP0002932_abnormal_joint_morphology | 0.73903992 |
| 107 | MP0003385_abnormal_body_wall | 0.73497943 |
| 108 | MP0003943_abnormal_hepatobiliary_system | 0.71531922 |
| 109 | MP0004185_abnormal_adipocyte_glucose | 0.70565925 |
| 110 | MP0002877_abnormal_melanocyte_morpholog | 0.70272591 |
| 111 | MP0002095_abnormal_skin_pigmentation | 0.68698889 |
| 112 | MP0005397_hematopoietic_system_phenotyp | 0.68565025 |
| 113 | MP0001545_abnormal_hematopoietic_system | 0.68565025 |
| 114 | MP0003935_abnormal_craniofacial_develop | 0.68089195 |
| 115 | MP0000432_abnormal_head_morphology | 0.67926396 |
| 116 | MP0002114_abnormal_axial_skeleton | 0.67692529 |
| 117 | MP0000358_abnormal_cell_content/ | 0.67558330 |
| 118 | MP0002161_abnormal_fertility/fecundity | 0.67120701 |
| 119 | MP0003861_abnormal_nervous_system | 0.66435626 |
| 120 | MP0005423_abnormal_somatic_nervous | 0.66240383 |
| 121 | MP0002092_abnormal_eye_morphology | 0.66034954 |
| 122 | MP0009278_abnormal_bone_marrow | 0.64903072 |
| 123 | MP0008789_abnormal_olfactory_epithelium | 0.64655446 |
| 124 | MP0002722_abnormal_immune_system | 0.64417157 |
| 125 | MP0005075_abnormal_melanosome_morpholog | 0.64247265 |
| 126 | MP0001324_abnormal_eye_pigmentation | 0.64163236 |
| 127 | MP0002398_abnormal_bone_marrow | 0.63976741 |
| 128 | MP0003699_abnormal_female_reproductive | 0.63414978 |
| 129 | MP0002282_abnormal_trachea_morphology | 0.63317938 |
| 130 | MP0005384_cellular_phenotype | 0.62367983 |
| 131 | MP0003448_altered_tumor_morphology | 0.62254891 |
| 132 | MP0005501_abnormal_skin_physiology | 0.61741450 |
| 133 | MP0000689_abnormal_spleen_morphology | 0.61504280 |
| 134 | MP0009703_decreased_birth_body | 0.61440403 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reticulocytopenia (HP:0001896) | 5.21460841 |
| 2 | Chromsome breakage (HP:0040012) | 4.21895906 |
| 3 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.19916129 |
| 4 | Breast hypoplasia (HP:0003187) | 4.19286873 |
| 5 | Carpal bone hypoplasia (HP:0001498) | 4.08153092 |
| 6 | Birth length less than 3rd percentile (HP:0003561) | 4.03071368 |
| 7 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.89473254 |
| 8 | Patellar aplasia (HP:0006443) | 3.68437618 |
| 9 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.60513165 |
| 10 | Abnormal number of erythroid precursors (HP:0012131) | 3.56031495 |
| 11 | Macrocytic anemia (HP:0001972) | 3.41547255 |
| 12 | Absent radius (HP:0003974) | 3.40250650 |
| 13 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.36000753 |
| 14 | Meckel diverticulum (HP:0002245) | 3.32276523 |
| 15 | Oral leukoplakia (HP:0002745) | 3.29964784 |
| 16 | Abnormality of the ileum (HP:0001549) | 3.26538550 |
| 17 | Pallor (HP:0000980) | 3.22518980 |
| 18 | Absent forearm bone (HP:0003953) | 3.17760632 |
| 19 | Aplasia involving forearm bones (HP:0009822) | 3.17760632 |
| 20 | Colon cancer (HP:0003003) | 3.16360974 |
| 21 | Abnormality of the preputium (HP:0100587) | 3.16317386 |
| 22 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.16276671 |
| 23 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 3.13924388 |
| 24 | Rough bone trabeculation (HP:0100670) | 3.08926383 |
| 25 | Acute necrotizing encephalopathy (HP:0006965) | 3.04670341 |
| 26 | Absent thumb (HP:0009777) | 3.03209875 |
| 27 | Selective tooth agenesis (HP:0001592) | 2.99713251 |
| 28 | Abnormal number of incisors (HP:0011064) | 2.96669805 |
| 29 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.96139836 |
| 30 | Increased hepatocellular lipid droplets (HP:0006565) | 2.93174744 |
| 31 | Triphalangeal thumb (HP:0001199) | 2.92094074 |
| 32 | Abnormality of chromosome stability (HP:0003220) | 2.89060700 |
| 33 | Acute encephalopathy (HP:0006846) | 2.87593657 |
| 34 | Horseshoe kidney (HP:0000085) | 2.82797854 |
| 35 | Concave nail (HP:0001598) | 2.78079884 |
| 36 | Impulsivity (HP:0100710) | 2.75312211 |
| 37 | Mitochondrial inheritance (HP:0001427) | 2.74747424 |
| 38 | Increased CSF lactate (HP:0002490) | 2.73508624 |
| 39 | Abnormality of the labia minora (HP:0012880) | 2.72760999 |
| 40 | Abnormality of the anterior horn cell (HP:0006802) | 2.69196086 |
| 41 | Degeneration of anterior horn cells (HP:0002398) | 2.69196086 |
| 42 | Premature graying of hair (HP:0002216) | 2.68779293 |
| 43 | Lipid accumulation in hepatocytes (HP:0006561) | 2.65173873 |
| 44 | Small intestinal stenosis (HP:0012848) | 2.63908961 |
| 45 | Duodenal stenosis (HP:0100867) | 2.63908961 |
| 46 | Medulloblastoma (HP:0002885) | 2.60043959 |
| 47 | Rhabdomyosarcoma (HP:0002859) | 2.57783745 |
| 48 | Supernumerary spleens (HP:0009799) | 2.57354871 |
| 49 | Ependymoma (HP:0002888) | 2.55574169 |
| 50 | Hepatocellular necrosis (HP:0001404) | 2.52980898 |
| 51 | Abnormality of DNA repair (HP:0003254) | 2.52214455 |
| 52 | Type 2 muscle fiber atrophy (HP:0003554) | 2.48174174 |
| 53 | Trismus (HP:0000211) | 2.48089179 |
| 54 | Tracheoesophageal fistula (HP:0002575) | 2.47964555 |
| 55 | Neoplasm of the pancreas (HP:0002894) | 2.43444006 |
| 56 | Muscle fiber atrophy (HP:0100295) | 2.41256177 |
| 57 | Duplicated collecting system (HP:0000081) | 2.40826901 |
| 58 | Agnosia (HP:0010524) | 2.38139299 |
| 59 | Cerebral hypomyelination (HP:0006808) | 2.36955554 |
| 60 | Bone marrow hypocellularity (HP:0005528) | 2.36863431 |
| 61 | Abnormal lung lobation (HP:0002101) | 2.36805977 |
| 62 | Poikiloderma (HP:0001029) | 2.36264628 |
| 63 | Myelodysplasia (HP:0002863) | 2.34283101 |
| 64 | Renal Fanconi syndrome (HP:0001994) | 2.33484265 |
| 65 | Ectopic kidney (HP:0000086) | 2.31677581 |
| 66 | Atresia of the external auditory canal (HP:0000413) | 2.31644830 |
| 67 | Increased intramyocellular lipid droplets (HP:0012240) | 2.26719035 |
| 68 | Abnormality of cochlea (HP:0000375) | 2.24525803 |
| 69 | Cleft eyelid (HP:0000625) | 2.23437553 |
| 70 | Sloping forehead (HP:0000340) | 2.22802572 |
| 71 | Aplastic anemia (HP:0001915) | 2.22010914 |
| 72 | Abnormal trabecular bone morphology (HP:0100671) | 2.21679064 |
| 73 | Abnormality of the duodenum (HP:0002246) | 2.20668748 |
| 74 | Progressive macrocephaly (HP:0004481) | 2.18793141 |
| 75 | 11 pairs of ribs (HP:0000878) | 2.18727538 |
| 76 | Increased serum lactate (HP:0002151) | 2.18232505 |
| 77 | Hepatic necrosis (HP:0002605) | 2.16671407 |
| 78 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.15938783 |
| 79 | Hypoplasia of the radius (HP:0002984) | 2.15714466 |
| 80 | Abnormal hemoglobin (HP:0011902) | 2.12560766 |
| 81 | Microvesicular hepatic steatosis (HP:0001414) | 2.10061945 |
| 82 | Secondary amenorrhea (HP:0000869) | 2.09775145 |
| 83 | Clubbing of toes (HP:0100760) | 2.08879642 |
| 84 | Cellular immunodeficiency (HP:0005374) | 2.07705756 |
| 85 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.06247475 |
| 86 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.06247475 |
| 87 | Abnormality of the renal collecting system (HP:0004742) | 2.04044470 |
| 88 | Abdominal situs inversus (HP:0003363) | 2.01825347 |
| 89 | Abnormality of abdominal situs (HP:0011620) | 2.01825347 |
| 90 | Premature ovarian failure (HP:0008209) | 2.01501056 |
| 91 | Cerebral edema (HP:0002181) | 2.00884376 |
| 92 | Basal cell carcinoma (HP:0002671) | 1.99856216 |
| 93 | Embryonal renal neoplasm (HP:0011794) | 1.98687217 |
| 94 | Type I transferrin isoform profile (HP:0003642) | 1.96774190 |
| 95 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.94713204 |
| 96 | Increased serum pyruvate (HP:0003542) | 1.93343062 |
| 97 | Short thumb (HP:0009778) | 1.92789095 |
| 98 | Sex reversal (HP:0012245) | 1.92483812 |
| 99 | Abnormal sex determination (HP:0012244) | 1.92483812 |
| 100 | Abnormality of the pons (HP:0007361) | 1.92133937 |
| 101 | Abnormality of glycolysis (HP:0004366) | 1.90033255 |
| 102 | Hypoplasia of the pons (HP:0012110) | 1.89907659 |
| 103 | Exercise intolerance (HP:0003546) | 1.88923112 |
| 104 | Facial cleft (HP:0002006) | 1.86904093 |
| 105 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.86445020 |
| 106 | Abnormality of reticulocytes (HP:0004312) | 1.85886072 |
| 107 | Microretrognathia (HP:0000308) | 1.84996377 |
| 108 | Lactic acidosis (HP:0003128) | 1.84346105 |
| 109 | Hypoplastic pelvis (HP:0008839) | 1.83135846 |
| 110 | Respiratory difficulties (HP:0002880) | 1.81062997 |
| 111 | Rib fusion (HP:0000902) | 1.80327091 |
| 112 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.79976905 |
| 113 | Abnormality of the carotid arteries (HP:0005344) | 1.78929104 |
| 114 | Increased muscle lipid content (HP:0009058) | 1.78916041 |
| 115 | Duplication of thumb phalanx (HP:0009942) | 1.78847397 |
| 116 | Abnormality of renal resorption (HP:0011038) | 1.78131525 |
| 117 | Volvulus (HP:0002580) | 1.76589655 |
| 118 | Increased nuchal translucency (HP:0010880) | 1.76121156 |
| 119 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.75053880 |
| 120 | Diastasis recti (HP:0001540) | 1.74897319 |
| 121 | Homocystinuria (HP:0002156) | 1.74668092 |
| 122 | Abnormality of homocysteine metabolism (HP:0010919) | 1.74668092 |
| 123 | Tetralogy of Fallot (HP:0001636) | 1.73882915 |
| 124 | Neoplasm of striated muscle (HP:0009728) | 1.73682470 |
| 125 | Facial hemangioma (HP:0000329) | 1.73266884 |
| 126 | Progressive muscle weakness (HP:0003323) | 1.73036233 |
| 127 | Vaginal fistula (HP:0004320) | 1.72858649 |
| 128 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.72203096 |
| 129 | Cortical dysplasia (HP:0002539) | 1.71173160 |
| 130 | Squamous cell carcinoma (HP:0002860) | 1.71169800 |
| 131 | Holoprosencephaly (HP:0001360) | 1.70964029 |
| 132 | Broad alveolar ridges (HP:0000187) | 1.69111971 |
| 133 | Sclerocornea (HP:0000647) | 1.69090620 |
| 134 | Pancytopenia (HP:0001876) | 1.67664180 |
| 135 | Exertional dyspnea (HP:0002875) | 1.67045592 |
| 136 | High anterior hairline (HP:0009890) | 1.66955795 |
| 137 | Cafe-au-lait spot (HP:0000957) | 1.66836693 |
| 138 | Depressed nasal ridge (HP:0000457) | 1.66311319 |
| 139 | Multiple enchondromatosis (HP:0005701) | 1.65443580 |
| 140 | Rectal fistula (HP:0100590) | 1.64411929 |
| 141 | Rectovaginal fistula (HP:0000143) | 1.64411929 |
| 142 | Neoplasm of the colon (HP:0100273) | 1.63785366 |
| 143 | Choanal atresia (HP:0000453) | 1.62348008 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.87435092 |
| 2 | TLK1 | 4.53925238 |
| 3 | WEE1 | 4.04810575 |
| 4 | VRK2 | 3.56189477 |
| 5 | CDC7 | 3.49244037 |
| 6 | EIF2AK1 | 3.21327284 |
| 7 | NME2 | 2.69501993 |
| 8 | SRPK1 | 2.61015713 |
| 9 | NEK2 | 2.48269230 |
| 10 | TTK | 2.40754917 |
| 11 | PLK1 | 2.18954594 |
| 12 | TAF1 | 2.09455491 |
| 13 | MKNK2 | 2.08393828 |
| 14 | TESK2 | 2.06732404 |
| 15 | PLK4 | 2.06179853 |
| 16 | BRSK2 | 2.03251982 |
| 17 | STK16 | 1.90367532 |
| 18 | DYRK3 | 1.89925984 |
| 19 | VRK1 | 1.88779234 |
| 20 | MKNK1 | 1.88006042 |
| 21 | RPS6KA4 | 1.81674308 |
| 22 | CDK7 | 1.75833943 |
| 23 | AURKB | 1.70138116 |
| 24 | BRSK1 | 1.67040881 |
| 25 | AURKA | 1.56325702 |
| 26 | CHEK2 | 1.55115445 |
| 27 | SMG1 | 1.53267226 |
| 28 | TSSK6 | 1.53161144 |
| 29 | PLK3 | 1.48509594 |
| 30 | ATR | 1.44884085 |
| 31 | NEK1 | 1.42956380 |
| 32 | PDK2 | 1.30223941 |
| 33 | EIF2AK3 | 1.27962031 |
| 34 | MAP3K10 | 1.23911739 |
| 35 | CDK4 | 1.22963635 |
| 36 | MAP3K8 | 1.22574173 |
| 37 | PASK | 1.19426132 |
| 38 | NUAK1 | 1.16738541 |
| 39 | CCNB1 | 1.15731095 |
| 40 | RPS6KB2 | 1.15695235 |
| 41 | CHEK1 | 1.15321271 |
| 42 | PBK | 1.12541559 |
| 43 | EPHA2 | 1.09489331 |
| 44 | PIM2 | 1.09216135 |
| 45 | ACVR1B | 1.07304922 |
| 46 | BRAF | 1.07156616 |
| 47 | MAP3K11 | 1.04176038 |
| 48 | STK4 | 1.03759866 |
| 49 | CDK12 | 1.01962843 |
| 50 | ARAF | 0.98526979 |
| 51 | PNCK | 0.97252458 |
| 52 | WNK4 | 0.96896643 |
| 53 | STK10 | 0.96126075 |
| 54 | BCKDK | 0.89106025 |
| 55 | CDK8 | 0.84871993 |
| 56 | CDK2 | 0.83837530 |
| 57 | LATS2 | 0.82555894 |
| 58 | ATM | 0.80562082 |
| 59 | CSNK2A1 | 0.80127235 |
| 60 | BLK | 0.79419179 |
| 61 | PAK1 | 0.79385276 |
| 62 | YES1 | 0.77259826 |
| 63 | MST4 | 0.76575061 |
| 64 | CSNK2A2 | 0.76078258 |
| 65 | MELK | 0.75995794 |
| 66 | CSNK1G3 | 0.73132524 |
| 67 | EIF2AK2 | 0.72103148 |
| 68 | PAK4 | 0.68990210 |
| 69 | UHMK1 | 0.67579098 |
| 70 | PIM1 | 0.67243304 |
| 71 | CDK1 | 0.65995671 |
| 72 | CDK6 | 0.64485382 |
| 73 | RPS6KA5 | 0.63659236 |
| 74 | ZAK | 0.62408264 |
| 75 | CSNK1A1L | 0.62269943 |
| 76 | PRKCI | 0.62139429 |
| 77 | MAPKAPK5 | 0.61400605 |
| 78 | DYRK2 | 0.59895114 |
| 79 | TESK1 | 0.59873641 |
| 80 | MUSK | 0.57522456 |
| 81 | CDK15 | 0.55818283 |
| 82 | NME1 | 0.55295503 |
| 83 | CSNK1G1 | 0.54444051 |
| 84 | CLK1 | 0.54096710 |
| 85 | STK38L | 0.52237739 |
| 86 | CDK18 | 0.51393592 |
| 87 | TAOK2 | 0.50892129 |
| 88 | BMPR1B | 0.50644422 |
| 89 | MAPK15 | 0.50605979 |
| 90 | CSNK1G2 | 0.49982375 |
| 91 | SCYL2 | 0.47993951 |
| 92 | CDK14 | 0.47742545 |
| 93 | NEK9 | 0.46206770 |
| 94 | ABL2 | 0.45049707 |
| 95 | ALK | 0.43756993 |
| 96 | AKT3 | 0.42588053 |
| 97 | RPS6KL1 | 0.39606899 |
| 98 | RPS6KC1 | 0.39606899 |
| 99 | CDK3 | 0.39034896 |
| 100 | IRAK3 | 0.38936558 |
| 101 | CDK9 | 0.38791531 |
| 102 | BRD4 | 0.37511210 |
| 103 | CSNK1E | 0.35456505 |
| 104 | PRKDC | 0.34646226 |
| 105 | CAMK1G | 0.32500604 |
| 106 | MST1R | 0.32426036 |
| 107 | CAMK1D | 0.32368374 |
| 108 | DAPK3 | 0.31347135 |
| 109 | RAF1 | 0.31309702 |
| 110 | IRAK4 | 0.31171225 |
| 111 | EPHB2 | 0.30556060 |
| 112 | ICK | 0.30537181 |
| 113 | RPS6KA6 | 0.30120292 |
| 114 | AKT2 | 0.28967343 |
| 115 | KDR | 0.28306809 |
| 116 | MAPK14 | 0.27379994 |
| 117 | PLK2 | 0.26769226 |
| 118 | CDK11A | 0.26635556 |
| 119 | IKBKB | 0.26169901 |
| 120 | RPS6KA1 | 0.25565739 |
| 121 | CDK19 | 0.25102491 |
| 122 | TGFBR1 | 0.24894515 |
| 123 | EEF2K | 0.24786138 |
| 124 | MET | 0.24405137 |
| 125 | WNK3 | 0.24388165 |
| 126 | DAPK1 | 0.24094941 |
| 127 | ERBB4 | 0.24005475 |
| 128 | STK3 | 0.22993990 |
| 129 | MAPK11 | 0.21840523 |
| 130 | FLT3 | 0.21318918 |
| 131 | DYRK1B | 0.21096951 |
| 132 | AKT1 | 0.19552512 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.02313450 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.38472173 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.35061151 |
| 4 | Spliceosome_Homo sapiens_hsa03040 | 3.50975885 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.44787605 |
| 6 | Base excision repair_Homo sapiens_hsa03410 | 3.44731664 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.37055580 |
| 8 | * Homologous recombination_Homo sapiens_hsa03440 | 3.32174374 |
| 9 | Proteasome_Homo sapiens_hsa03050 | 3.17896912 |
| 10 | RNA transport_Homo sapiens_hsa03013 | 2.94053357 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.93626737 |
| 12 | Cell cycle_Homo sapiens_hsa04110 | 2.64940386 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.53073535 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.50289655 |
| 15 | * Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.46371294 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.19387992 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.97278675 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.95138949 |
| 19 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.75828779 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.73975244 |
| 21 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.48739011 |
| 22 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.24678777 |
| 23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.23156018 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.22608027 |
| 25 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.18634605 |
| 26 | Sulfur relay system_Homo sapiens_hsa04122 | 1.16337473 |
| 27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.15272465 |
| 28 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.14685040 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.12338949 |
| 30 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.05564219 |
| 31 | Protein export_Homo sapiens_hsa03060 | 1.04904285 |
| 32 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.02476039 |
| 33 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.98490880 |
| 34 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.93756436 |
| 35 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.92419436 |
| 36 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.87806712 |
| 37 | Huntingtons disease_Homo sapiens_hsa05016 | 0.85012000 |
| 38 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.84814387 |
| 39 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.77410167 |
| 40 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.76127242 |
| 41 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.73164947 |
| 42 | Parkinsons disease_Homo sapiens_hsa05012 | 0.70500819 |
| 43 | HTLV-I infection_Homo sapiens_hsa05166 | 0.68418304 |
| 44 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.66534011 |
| 45 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.65829700 |
| 46 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.64737672 |
| 47 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.64020678 |
| 48 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.62201986 |
| 49 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.61736333 |
| 50 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.56370183 |
| 51 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.56362608 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.55740148 |
| 53 | Bladder cancer_Homo sapiens_hsa05219 | 0.54139182 |
| 54 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.53971918 |
| 55 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.53948284 |
| 56 | Alcoholism_Homo sapiens_hsa05034 | 0.51615429 |
| 57 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.51475859 |
| 58 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.50812412 |
| 59 | Legionellosis_Homo sapiens_hsa05134 | 0.49448527 |
| 60 | Thyroid cancer_Homo sapiens_hsa05216 | 0.49225353 |
| 61 | Lysine degradation_Homo sapiens_hsa00310 | 0.49153998 |
| 62 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.47274771 |
| 63 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.45856123 |
| 64 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.45026832 |
| 65 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.44292278 |
| 66 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.43952591 |
| 67 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.43516152 |
| 68 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.43084620 |
| 69 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.37934041 |
| 70 | Apoptosis_Homo sapiens_hsa04210 | 0.36646573 |
| 71 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.36613346 |
| 72 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.35673955 |
| 73 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.35074306 |
| 74 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.34565492 |
| 75 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.33408770 |
| 76 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.31959986 |
| 77 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.31381725 |
| 78 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.30965331 |
| 79 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.30762346 |
| 80 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.30174601 |
| 81 | Hepatitis B_Homo sapiens_hsa05161 | 0.28247173 |
| 82 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.27649602 |
| 83 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.26174724 |
| 84 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.25634759 |
| 85 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.24060290 |
| 86 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.23915072 |
| 87 | Pathways in cancer_Homo sapiens_hsa05200 | 0.22507874 |
| 88 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.22481480 |
| 89 | Colorectal cancer_Homo sapiens_hsa05210 | 0.21248081 |
| 90 | Alzheimers disease_Homo sapiens_hsa05010 | 0.21173820 |
| 91 | Prostate cancer_Homo sapiens_hsa05215 | 0.21008529 |
| 92 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.20957843 |
| 93 | Shigellosis_Homo sapiens_hsa05131 | 0.19644523 |
| 94 | Measles_Homo sapiens_hsa05162 | 0.18945958 |
| 95 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.18925490 |
| 96 | Galactose metabolism_Homo sapiens_hsa00052 | 0.18671954 |
| 97 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.18076715 |
| 98 | Metabolic pathways_Homo sapiens_hsa01100 | 0.17469108 |
| 99 | Melanoma_Homo sapiens_hsa05218 | 0.16805543 |
| 100 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.16675387 |
| 101 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.16485546 |
| 102 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.16289819 |
| 103 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.15713321 |
| 104 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.14272060 |
| 105 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.14149607 |
| 106 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.13318552 |
| 107 | Asthma_Homo sapiens_hsa05310 | 0.13048162 |
| 108 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.12647192 |
| 109 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.11441092 |
| 110 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.10218590 |
| 111 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.10183158 |
| 112 | Peroxisome_Homo sapiens_hsa04146 | 0.09541493 |
| 113 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.09307779 |
| 114 | Influenza A_Homo sapiens_hsa05164 | 0.08339969 |
| 115 | Carbon metabolism_Homo sapiens_hsa01200 | 0.08151921 |
| 116 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.07887426 |
| 117 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.06012186 |
| 118 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.05199322 |
| 119 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.05126382 |
| 120 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.04907405 |
| 121 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.04516377 |
| 122 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.04328130 |
| 123 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.03949134 |
| 124 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.03800489 |
| 125 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.03527778 |
| 126 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.01649382 |

