EML2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.56590606
2cAMP biosynthetic process (GO:0006171)6.48383583
3positive regulation of vascular permeability (GO:0043117)6.04316708
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.95891193
5cGMP-mediated signaling (GO:0019934)5.81129087
6locomotory exploration behavior (GO:0035641)5.69432341
7molting cycle (GO:0042303)5.60354526
8hair cycle (GO:0042633)5.60354526
9citrulline biosynthetic process (GO:0019240)5.59826779
10cAMP metabolic process (GO:0046058)5.59314196
11cAMP catabolic process (GO:0006198)5.59051178
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.38806676
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.33361094
14citrulline metabolic process (GO:0000052)5.11111071
15positive regulation of prostaglandin secretion (GO:0032308)4.95269174
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.94294499
17glutamate secretion (GO:0014047)4.93377016
18negative regulation of vascular permeability (GO:0043116)4.91077434
19cyclic nucleotide catabolic process (GO:0009214)4.89549259
20regulation of synaptic vesicle exocytosis (GO:2000300)4.84757257
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.82920230
22sodium ion export (GO:0071436)4.79814065
23synaptic vesicle exocytosis (GO:0016079)4.79299751
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.72373998
25vocalization behavior (GO:0071625)4.72217195
26response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.69135296
27urea cycle (GO:0000050)4.47030306
28layer formation in cerebral cortex (GO:0021819)4.46145500
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.45289672
30cellular potassium ion homeostasis (GO:0030007)4.45271863
31glomerular visceral epithelial cell development (GO:0072015)4.44762423
32regulation of prostaglandin secretion (GO:0032306)4.44722076
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.44044869
34carnitine shuttle (GO:0006853)4.44018732
35nuclear pore complex assembly (GO:0051292)4.42441758
36regulation of synapse structural plasticity (GO:0051823)4.39524606
37neurotransmitter secretion (GO:0007269)4.33984131
38desmosome organization (GO:0002934)4.33125850
39negative regulation of catenin import into nucleus (GO:0035414)4.32621389
40regulation of synaptic vesicle transport (GO:1902803)4.31608961
41positive regulation of fatty acid biosynthetic process (GO:0045723)4.30107456
42regulation of cell communication by electrical coupling (GO:0010649)4.28897173
43regulation of glutamate receptor signaling pathway (GO:1900449)4.28412901
44regulation of neuronal synaptic plasticity (GO:0048168)4.25915441
45regulation of relaxation of muscle (GO:1901077)4.24676854
46activation of protein kinase A activity (GO:0034199)4.19513996
47glycine transport (GO:0015816)4.19396418
48exploration behavior (GO:0035640)4.15128339
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.09136867
50regulation of long-term neuronal synaptic plasticity (GO:0048169)4.09089092
51glomerular basement membrane development (GO:0032836)4.08576910
52response to inactivity (GO:0014854)4.05946086
53regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.05356298
54response to dexamethasone (GO:0071548)4.03715222
55glomerular epithelial cell development (GO:0072310)4.03391400
56gamma-aminobutyric acid transport (GO:0015812)4.02939262
57neuronal action potential propagation (GO:0019227)4.00135492
58proline transport (GO:0015824)3.99316796
59positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.94447847
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.91418525
61urea metabolic process (GO:0019627)3.90465554
62midgut development (GO:0007494)3.86137224
63neuromuscular process controlling balance (GO:0050885)3.85446578
64cellular response to glucagon stimulus (GO:0071377)3.84580949
65glomerular filtration (GO:0003094)3.83696238
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83158375
67regulation of cardiac muscle cell contraction (GO:0086004)3.82396892
68ionotropic glutamate receptor signaling pathway (GO:0035235)3.81319677
69carnitine transmembrane transport (GO:1902603)3.80054857
70regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.77346993
71regulation of actin filament-based movement (GO:1903115)3.77099907
72cell communication by electrical coupling (GO:0010644)3.76772656
73ventricular cardiac muscle cell action potential (GO:0086005)3.74354244
74innate immune response in mucosa (GO:0002227)3.73717779
75protein localization to synapse (GO:0035418)3.70826266
76dendritic spine morphogenesis (GO:0060997)3.65886140
77nuclear pore organization (GO:0006999)3.65756122
78cellular response to epinephrine stimulus (GO:0071872)3.65638329
79regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.65628337
80DNA unwinding involved in DNA replication (GO:0006268)3.64237065
81neuromuscular process controlling posture (GO:0050884)3.61780166
82peptidyl-lysine dimethylation (GO:0018027)3.61240643
83hemidesmosome assembly (GO:0031581)3.61221573
84renal filtration (GO:0097205)3.61200270
85cyclic nucleotide metabolic process (GO:0009187)3.60761297
86plasma membrane repair (GO:0001778)3.59893094
87snRNA processing (GO:0016180)3.59548823
88pyrimidine dimer repair (GO:0006290)3.56803731
89potassium ion import (GO:0010107)3.55168851
90nitrogen cycle metabolic process (GO:0071941)3.54669866
91response to epinephrine (GO:0071871)3.52732449
92fatty acid transmembrane transport (GO:1902001)3.51215491
93vesicle transport along microtubule (GO:0047496)3.47224140
94neurotransmitter transport (GO:0006836)3.46129814
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.45312436
96regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.44608359
97T cell mediated immunity (GO:0002456)3.44154134
98sarcoplasmic reticulum calcium ion transport (GO:0070296)3.40479809
99regulation of ARF protein signal transduction (GO:0032012)3.39540035
100snRNA metabolic process (GO:0016073)3.39492311
101long-term memory (GO:0007616)3.37051121
102cyclic nucleotide biosynthetic process (GO:0009190)3.36386638
103prepulse inhibition (GO:0060134)3.33077071
104cyclic purine nucleotide metabolic process (GO:0052652)3.33042772
105amino-acid betaine transport (GO:0015838)3.32857141
106carnitine transport (GO:0015879)3.32857141
107cytoskeletal anchoring at plasma membrane (GO:0007016)3.30395283
108natural killer cell mediated immunity (GO:0002228)3.29775992
109natural killer cell mediated cytotoxicity (GO:0042267)3.29775992
110chaperone-mediated protein folding (GO:0061077)3.29282534
111synaptic transmission, glutamatergic (GO:0035249)3.29176869
112pore complex assembly (GO:0046931)3.27172745
113neuron cell-cell adhesion (GO:0007158)3.25662836
114sarcomere organization (GO:0045214)3.25608488
115potassium ion homeostasis (GO:0055075)3.24597798
116regulation of neurotransmitter levels (GO:0001505)3.23104418
117negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.21676526
118response to caffeine (GO:0031000)3.20232092
119positive regulation of membrane potential (GO:0045838)3.19241514
120regulation of synaptic plasticity (GO:0048167)3.19083175
121positive regulation of synaptic transmission, GABAergic (GO:0032230)3.18628344
122homocysteine metabolic process (GO:0050667)3.18457684
123regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.17461106
124neurotransmitter-gated ion channel clustering (GO:0072578)3.16422818
125response to glucagon (GO:0033762)3.15383297
126cerebellar Purkinje cell differentiation (GO:0021702)3.15096348
127positive regulation of cation channel activity (GO:2001259)3.14680002
128cellular sodium ion homeostasis (GO:0006883)3.13360054
129neuronal ion channel clustering (GO:0045161)3.12660806
130neuron-neuron synaptic transmission (GO:0007270)3.11711950
131cell communication involved in cardiac conduction (GO:0086065)3.10770391
132regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08729400
133glutamate receptor signaling pathway (GO:0007215)3.08579918
134response to auditory stimulus (GO:0010996)3.08338270
135axon cargo transport (GO:0008088)3.07166064
136mating behavior (GO:0007617)3.06499120
137auditory behavior (GO:0031223)3.06055062
138membrane depolarization during action potential (GO:0086010)3.06043247
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05965091
140cerebellar Purkinje cell layer development (GO:0021680)3.05481539
141positive regulation of icosanoid secretion (GO:0032305)3.05449949
142regulation of dendritic spine morphogenesis (GO:0061001)3.05366252
143regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03231715
144water transport (GO:0006833)3.02705994
145clathrin coat assembly (GO:0048268)3.02124905
146L-amino acid import (GO:0043092)3.01517415
147cAMP-mediated signaling (GO:0019933)3.01266461
148glycogen catabolic process (GO:0005980)3.01058677
149cardiac muscle hypertrophy (GO:0003300)3.00153719
150dendrite morphogenesis (GO:0048813)3.00089756
151positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99312233
152regulation of clathrin-mediated endocytosis (GO:2000369)2.98445347
153interkinetic nuclear migration (GO:0022027)2.98077566
154G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97462413
155regulation of neurotransmitter secretion (GO:0046928)2.97449207
156organelle transport along microtubule (GO:0072384)2.96548479
157neuromuscular process (GO:0050905)2.95663488
158synaptic vesicle endocytosis (GO:0048488)2.95100500
159transmission of nerve impulse (GO:0019226)2.94808460
160mucosal immune response (GO:0002385)2.93637156
161positive regulation of potassium ion transmembrane transport (GO:1901381)2.93419402
162detection of calcium ion (GO:0005513)2.92580329
163membrane repolarization (GO:0086009)2.92038967
164regulation of fatty acid biosynthetic process (GO:0042304)2.91701552
165regulation of postsynaptic membrane potential (GO:0060078)2.90942505
166cell migration in hindbrain (GO:0021535)2.87860080
167neuron recognition (GO:0008038)2.83890073
168regulation of neurotransmitter transport (GO:0051588)2.82685790
169antibacterial humoral response (GO:0019731)2.82342741
170striated muscle hypertrophy (GO:0014897)2.81022275
171positive regulation of synapse maturation (GO:0090129)2.80556433
172cardiac muscle cell action potential (GO:0086001)2.79898159
173positive regulation of fatty acid metabolic process (GO:0045923)2.79285852
174positive regulation of neurotransmitter transport (GO:0051590)2.79189603
175negative regulation of potassium ion transmembrane transport (GO:1901380)2.78940117
176regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.77551712
177membrane hyperpolarization (GO:0060081)2.76303053
178establishment of nucleus localization (GO:0040023)2.75001440
179cardiac muscle contraction (GO:0060048)2.74666009
180positive regulation of fatty acid transport (GO:2000193)2.74481276
181glucan catabolic process (GO:0009251)2.74423969
182regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.73445570
183regulation of vesicle fusion (GO:0031338)2.72528464
184dopamine receptor signaling pathway (GO:0007212)2.71770198
185adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.71434712
186regulation of ARF GTPase activity (GO:0032312)2.69993307
187membrane depolarization (GO:0051899)2.69690113
188positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.69183115
189positive regulation of potassium ion transport (GO:0043268)2.68915934
190regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68736825
191striated muscle atrophy (GO:0014891)2.68426823
192regulation of synaptic transmission, glutamatergic (GO:0051966)2.67601903
193adult walking behavior (GO:0007628)2.67237411
194membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.67037428
195long-term synaptic potentiation (GO:0060291)2.66854010
196chaperone mediated protein folding requiring cofactor (GO:0051085)16.3182898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse7.45260097
2E2F7_22180533_ChIP-Seq_HELA_Human5.01114137
3EZH2_22144423_ChIP-Seq_EOC_Human4.78057682
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.27637452
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.93666462
6DROSHA_22980978_ChIP-Seq_HELA_Human2.83687831
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73816453
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73283012
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68617287
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68584336
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.64412560
12GATA1_22025678_ChIP-Seq_K562_Human2.60368712
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55729660
14VDR_21846776_ChIP-Seq_THP-1_Human2.55425595
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53533787
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53533787
17TP53_16413492_ChIP-PET_HCT116_Human2.52822670
18REST_21632747_ChIP-Seq_MESCs_Mouse2.46809117
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45908184
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44373823
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39872091
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19721512
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17316639
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.17225933
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16688574
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16040534
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.09683198
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04951682
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.03995834
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse14.1885331
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.96158572
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94950804
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.92123718
34KDM2B_26808549_Chip-Seq_K562_Human1.91188491
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88804306
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.87597713
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82557290
38GBX2_23144817_ChIP-Seq_PC3_Human1.81908982
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78526422
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.77747044
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73789240
42FUS_26573619_Chip-Seq_HEK293_Human1.70928922
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.69234280
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67531966
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.67378808
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67272276
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62378560
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62056352
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54991959
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54905314
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54905314
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54791136
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53800561
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.48528497
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44889937
56* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44771791
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43148388
58AR_21572438_ChIP-Seq_LNCaP_Human1.42017112
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42010937
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40478016
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39734693
62TBX20_22080862_ChIP-Seq_HEART_Mouse1.39649552
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.39649552
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.38131830
65* LXR_22292898_ChIP-Seq_THP-1_Human1.34923087
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.34205395
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34177256
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31735820
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31043601
70* KDM2B_26808549_Chip-Seq_DND41_Human1.29155026
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24021937
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22168738
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21948704
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20149971
75CTCF_27219007_Chip-Seq_Bcells_Human1.18848502
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15795035
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15323339
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15222979
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.15090401
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.13778108
81AR_19668381_ChIP-Seq_PC3_Human1.12919888
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12675840
83* KDM2B_26808549_Chip-Seq_JURKAT_Human1.10598106
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10530788
85SMC4_20622854_ChIP-Seq_HELA_Human1.09342165
86* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09158245
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09072192
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.08616705
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08275970
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07556351
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.06364903
92AHR_22903824_ChIP-Seq_MCF-7_Human1.05916522
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04402942
94* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04113160
95ZNF263_19887448_ChIP-Seq_K562_Human1.01664090
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00596934
97SMAD4_21799915_ChIP-Seq_A2780_Human0.99415209
98KLF4_19829295_ChIP-Seq_ESCs_Human0.98741105
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97916635
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97434398
101* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97354346
102SCL_19346495_ChIP-Seq_HPC-7_Human0.97240015
103* RACK7_27058665_Chip-Seq_MCF-7_Human0.96971766
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94817954
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93951945
106UBF1/2_26484160_Chip-Seq_HMECs_Human0.93764954
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.93597770
108VDR_24763502_ChIP-Seq_THP-1_Human0.93231816
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93038787
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92693427
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.92566142
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92394771
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92300012
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92074714
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91934334
116OCT4_19829295_ChIP-Seq_ESCs_Human0.91906215
117CREB1_26743006_Chip-Seq_LNCaP_Human0.91851584
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.91201673
119* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90278143
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90151979
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90050043
122TFEB_21752829_ChIP-Seq_HELA_Human0.89999566
123STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89863485
124ZNF274_21170338_ChIP-Seq_K562_Hela0.89434874
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89296349
126CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88685989
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.87925297
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86305639
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85710129
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85677750
131IGF1R_20145208_ChIP-Seq_DFB_Human0.85158010
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85093838
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84581227
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84411154
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83429500
136RXR_22108803_ChIP-Seq_LS180_Human0.82544792
137TCF7_22412390_ChIP-Seq_EML_Mouse0.82311815
138* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81902580
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81256782
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81245539
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81235516
142SMAD4_21741376_ChIP-Seq_ESCs_Human0.80203512
143GATA1_19941826_ChIP-Seq_K562_Human0.79715747
144* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79167782
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79015172
146* STAT3_23295773_ChIP-Seq_U87_Human0.78748722
147TBX3_20139965_ChIP-Seq_ESCs_Mouse0.78573817
148P68_20966046_ChIP-Seq_HELA_Human0.78510007
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78182274
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.77742108
151TBX3_20139965_ChIP-Seq_MESCs_Mouse0.77713818
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77222737
153TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76810650
154PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75731334
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74878855
156RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74650553
157ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74631988
158JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73009528
159E2F1_21310950_ChIP-Seq_MCF-7_Human0.72536001
160STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.67890016
161EGR1_19374776_ChIP-ChIP_THP-1_Human0.66445444
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.65646379
163ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65565275
164* MAF_26560356_Chip-Seq_TH1_Human0.65342715
165SRY_22984422_ChIP-ChIP_TESTIS_Rat0.65205964
166MYC_19915707_ChIP-ChIP_AK7_Human0.61302424
167SOX2_18692474_ChIP-Seq_MESCs_Mouse0.61264271
168TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.60207647
169NFIB_24661679_ChIP-Seq_LUNG_Mouse0.59971881
170FOXM1_23109430_ChIP-Seq_U2OS_Human0.59377753
171KLF5_25053715_ChIP-Seq_YYC3_Human0.59109506
172* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.58447517
173MITF_21258399_ChIP-Seq_MELANOMA_Human0.57836860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.86872181
2MP0002009_preneoplasia4.81024122
3MP0001661_extended_life_span4.71975712
4MP0010352_gastrointestinal_tract_polyps4.15129250
5MP0003880_abnormal_central_pattern4.11377120
6MP0003635_abnormal_synaptic_transmissio4.08306915
7MP0004270_analgesia3.62911729
8MP0003950_abnormal_plasma_membrane3.19214554
9MP0009745_abnormal_behavioral_response3.14613884
10MP0002063_abnormal_learning/memory/cond3.10845389
11MP0002064_seizures3.05492834
12MP0002822_catalepsy3.04278702
13MP0009046_muscle_twitch2.82706309
14MP0005423_abnormal_somatic_nervous2.77314449
15MP0001968_abnormal_touch/_nociception2.73511185
16MP0002166_altered_tumor_susceptibility2.67213037
17MP0004858_abnormal_nervous_system2.62426789
18MP0003646_muscle_fatigue2.55503265
19MP0002734_abnormal_mechanical_nocicepti2.51154437
20MP0008057_abnormal_DNA_replication2.48216974
21MP0002272_abnormal_nervous_system2.45090193
22MP0003221_abnormal_cardiomyocyte_apopto2.43057915
23MP0003329_amyloid_beta_deposits2.42041182
24MP0004185_abnormal_adipocyte_glucose2.42038215
25MP0002572_abnormal_emotion/affect_behav2.40337953
26MP0001486_abnormal_startle_reflex2.39664451
27MP0002909_abnormal_adrenal_gland2.37525004
28MP0000749_muscle_degeneration2.28314446
29MP0002733_abnormal_thermal_nociception2.17492521
30MP0009780_abnormal_chondrocyte_physiolo2.13799906
31MP0002269_muscular_atrophy2.07987284
32MP0002735_abnormal_chemical_nociception2.07604165
33MP0008569_lethality_at_weaning2.04184322
34MP0001970_abnormal_pain_threshold2.04056284
35MP0001501_abnormal_sleep_pattern2.03569467
36MP0002006_tumorigenesis2.02637387
37MP0004811_abnormal_neuron_physiology1.94855449
38MP0000750_abnormal_muscle_regeneration1.93771945
39MP0004885_abnormal_endolymph1.91499238
40MP0002736_abnormal_nociception_after1.91434363
41MP0004087_abnormal_muscle_fiber1.88318133
42MP0005666_abnormal_adipose_tissue1.85052168
43MP0001440_abnormal_grooming_behavior1.79398317
44MP0002332_abnormal_exercise_endurance1.76186143
45MP0003763_abnormal_thymus_physiology1.71824859
46MP0005451_abnormal_body_composition1.71127500
47MP0003283_abnormal_digestive_organ1.68096274
48MP0000579_abnormal_nail_morphology1.67975734
49MP0000955_abnormal_spinal_cord1.67666426
50MP0005171_absent_coat_pigmentation1.67342424
51MP0002067_abnormal_sensory_capabilities1.65686626
52MP0001984_abnormal_olfaction1.65259301
53MP0005375_adipose_tissue_phenotype1.65188454
54MP0005083_abnormal_biliary_tract1.61536591
55MP0003633_abnormal_nervous_system1.61528439
56MP0002184_abnormal_innervation1.58290348
57MP0008961_abnormal_basal_metabolism1.54355490
58MP0000733_abnormal_muscle_development1.52988416
59MP0004381_abnormal_hair_follicle1.52771935
60MP0005167_abnormal_blood-brain_barrier1.51271535
61MP0005076_abnormal_cell_differentiation1.49799458
62MP0003075_altered_response_to1.49214572
63MP0000383_abnormal_hair_follicle1.47836509
64MP0010678_abnormal_skin_adnexa1.47432754
65MP0002557_abnormal_social/conspecific_i1.46505181
66MP0005330_cardiomyopathy1.45973169
67MP0005386_behavior/neurological_phenoty1.45907928
68MP0004924_abnormal_behavior1.45907928
69MP0000751_myopathy1.44218648
70MP0003705_abnormal_hypodermis_morpholog1.43930430
71MP0005275_abnormal_skin_tensile1.43455931
72MP0000778_abnormal_nervous_system1.39630683
73MP0002066_abnormal_motor_capabilities/c1.39349940
74MP0000759_abnormal_skeletal_muscle1.37651027
75MP0003690_abnormal_glial_cell1.37583343
76MP0003453_abnormal_keratinocyte_physiol1.37016086
77MP0002877_abnormal_melanocyte_morpholog1.36532175
78MP0003879_abnormal_hair_cell1.36190394
79MP0010234_abnormal_vibrissa_follicle1.35206120
80MP0002882_abnormal_neuron_morphology1.33761956
81MP0005623_abnormal_meninges_morphology1.32051972
82MP0003631_nervous_system_phenotype1.27402898
83MP0000920_abnormal_myelination1.26602245
84MP0005647_abnormal_sex_gland1.26430724
85MP0000604_amyloidosis1.24956305
86MP0003172_abnormal_lysosome_physiology1.21617790
87MP0008438_abnormal_cutaneous_collagen1.20464409
88MP0002106_abnormal_muscle_physiology1.19540761
89MP0003634_abnormal_glial_cell1.19153476
90MP0005646_abnormal_pituitary_gland1.16536682
91MP0005165_increased_susceptibility_to1.16292043
92MP0000013_abnormal_adipose_tissue1.13342927
93MP0008874_decreased_physiological_sensi1.10881067
94MP0001216_abnormal_epidermal_layer1.04196101
95MP0002229_neurodegeneration1.04032282
96MP0010630_abnormal_cardiac_muscle1.02227417
97MP0001243_abnormal_dermal_layer1.01022447
98MP0000747_muscle_weakness1.00217290
99MP0002152_abnormal_brain_morphology1.00073259
100MP0005670_abnormal_white_adipose0.99780781
101MP0006276_abnormal_autonomic_nervous0.99764413
102MP0003787_abnormal_imprinting0.99622506
103MP0005645_abnormal_hypothalamus_physiol0.98666484
104MP0008872_abnormal_physiological_respon0.98468596
105MP0002972_abnormal_cardiac_muscle0.97817902
106MP0004142_abnormal_muscle_tone0.97671481
107MP0004130_abnormal_muscle_cell0.96034432
108MP0001986_abnormal_taste_sensitivity0.95204358
109MP0001177_atelectasis0.94602562
110MP0004808_abnormal_hematopoietic_stem0.93167638
111MP0001502_abnormal_circadian_rhythm0.92233644
112MP0004085_abnormal_heartbeat0.90530064
113MP0002971_abnormal_brown_adipose0.90204277
114MP0002060_abnormal_skin_morphology0.90037249
115MP0000377_abnormal_hair_follicle0.89550717
116MP0003122_maternal_imprinting0.88780715
117MP0003183_abnormal_peptide_metabolism0.88297649
118MP0003632_abnormal_nervous_system0.86819248
119MP0004510_myositis0.86470378
120MP0003137_abnormal_impulse_conducting0.84897171
121MP0002069_abnormal_eating/drinking_beha0.84535612
122MP0000569_abnormal_digit_pigmentation0.84050899
123MP0005369_muscle_phenotype0.82693040
124MP0005535_abnormal_body_temperature0.80192926
125MP0004145_abnormal_muscle_electrophysio0.79928781
126MP0001958_emphysema0.77957091
127MP0001348_abnormal_lacrimal_gland0.77956164
128MP0000427_abnormal_hair_cycle0.77748239
129MP0002837_dystrophic_cardiac_calcinosis0.75516525
130MP0009697_abnormal_copulation0.74691838
131MP0010094_abnormal_chromosome_stability0.74637124
132MP0004233_abnormal_muscle_weight0.74548127
133MP0000490_abnormal_crypts_of0.74385631
134MP0009115_abnormal_fat_cell0.74150234
135MP0010307_abnormal_tumor_latency0.73092926
136MP0004484_altered_response_of0.72847117
137MP0001905_abnormal_dopamine_level0.72665872
138MP0004084_abnormal_cardiac_muscle0.70956243
139MP0005166_decreased_susceptibility_to0.70829892
140MP0004036_abnormal_muscle_relaxation0.70545285
141MP0003303_peritoneal_inflammation0.70454487
142MP0005620_abnormal_muscle_contractility0.70335830
143MP0004215_abnormal_myocardial_fiber0.69081620
144MP0001299_abnormal_eye_distance/0.67929467
145MP0004043_abnormal_pH_regulation0.67358184
146MP0000003_abnormal_adipose_tissue0.66672248
147MP0005499_abnormal_olfactory_system0.66595192
148MP0005394_taste/olfaction_phenotype0.66595192
149MP0003786_premature_aging0.66538344
150MP0002396_abnormal_hematopoietic_system0.66403241
151MP0006138_congestive_heart_failure0.65321613
152MP0002090_abnormal_vision0.65044752
153MP0001485_abnormal_pinna_reflex0.65021099
154MP0005266_abnormal_metabolism0.64721505
155MP0003091_abnormal_cell_migration0.64235889
156MP0005023_abnormal_wound_healing0.61463131
157MP0004134_abnormal_chest_morphology0.61371702
158MP0005584_abnormal_enzyme/coenzyme_acti0.59447209
159MP0001873_stomach_inflammation0.59232737
160MP0003045_fibrosis0.58935536
161MP0003191_abnormal_cellular_cholesterol0.57555198
162MP0001943_abnormal_respiration0.57026491
163MP0002752_abnormal_somatic_nervous0.55614961
164MP0000367_abnormal_coat/_hair0.54485920
165MP0000534_abnormal_ureter_morphology0.53879640
166MP0008058_abnormal_DNA_repair0.53835092
167MP0004742_abnormal_vestibular_system0.53827313
168MP0001664_abnormal_digestion0.53622869
169MP0001529_abnormal_vocalization0.53564454
170MP0003656_abnormal_erythrocyte_physiolo0.51131648
171MP0010155_abnormal_intestine_physiology0.47453243

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.90115035
2Focal motor seizures (HP:0011153)5.42560560
3Milia (HP:0001056)5.09364401
4Short 4th metacarpal (HP:0010044)5.01772661
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.01772661
6Visual hallucinations (HP:0002367)4.87657980
7Right ventricular cardiomyopathy (HP:0011663)4.77127326
8Supranuclear gaze palsy (HP:0000605)4.69003664
9Focal seizures (HP:0007359)4.62786987
10Increased circulating renin level (HP:0000848)4.47870982
11Abnormality of the parietal bone (HP:0002696)4.33763078
12Action tremor (HP:0002345)4.21694589
13Ankle clonus (HP:0011448)4.20728841
14Short phalanx of the thumb (HP:0009660)4.18352184
15Deformed sella turcica (HP:0002681)4.03952609
16Medulloblastoma (HP:0002885)4.03396470
17Hyporeflexia of lower limbs (HP:0002600)3.87261197
18Abnormality of the 4th metacarpal (HP:0010012)3.80874048
19Abnormality of the distal phalanx of the thumb (HP:0009617)3.74846020
20Down-sloping shoulders (HP:0200021)3.65815524
21Ventricular tachycardia (HP:0004756)3.62854870
22Myoglobinuria (HP:0002913)3.61930465
23Entropion (HP:0000621)3.53944703
24Ventricular fibrillation (HP:0001663)3.49151161
25Depression (HP:0000716)3.45052775
26Increased connective tissue (HP:0009025)3.40273313
27Postural instability (HP:0002172)3.33381964
28Atonic seizures (HP:0010819)3.28397798
29Papilledema (HP:0001085)3.28095977
30Neoplasm of the oral cavity (HP:0100649)3.26364025
31Mutism (HP:0002300)3.21459043
32Progressive cerebellar ataxia (HP:0002073)3.20668616
33Abnormality of the sella turcica (HP:0002679)3.19073926
34Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.18823070
35Abnormality of the lower motor neuron (HP:0002366)3.16297366
36Generalized tonic-clonic seizures (HP:0002069)3.14573914
37Urinary bladder sphincter dysfunction (HP:0002839)3.14068089
38Urinary urgency (HP:0000012)3.13198318
39Abnormal auditory evoked potentials (HP:0006958)3.12181529
40Absence seizures (HP:0002121)3.11388127
41Insomnia (HP:0100785)3.11347106
42Neoplasm of striated muscle (HP:0009728)3.10090609
43Torticollis (HP:0000473)3.05513120
44Exercise-induced myalgia (HP:0003738)3.04497097
45Impaired vibration sensation in the lower limbs (HP:0002166)3.04471365
46Epileptic encephalopathy (HP:0200134)3.01508258
47Supernumerary ribs (HP:0005815)2.93457592
48Neurofibrillary tangles (HP:0002185)2.92948820
49Poor eye contact (HP:0000817)2.91754688
50Difficulty running (HP:0009046)2.91753590
51Hemiplegia (HP:0002301)2.90668357
52Febrile seizures (HP:0002373)2.90373196
53Annular pancreas (HP:0001734)2.89198221
54Frequent falls (HP:0002359)2.85876377
55Bundle branch block (HP:0011710)2.85231746
56Cerebral inclusion bodies (HP:0100314)2.84540944
57Generalized muscle weakness (HP:0003324)2.84525389
58Impaired social interactions (HP:0000735)2.83830317
59Abnormal social behavior (HP:0012433)2.83830317
60Dysmetria (HP:0001310)2.81482529
61Insidious onset (HP:0003587)2.77564801
62Termporal pattern (HP:0011008)2.77564801
63Abnormal ossification of hand bones (HP:0005921)2.77507498
64Anxiety (HP:0000739)2.77044263
65Dialeptic seizures (HP:0011146)2.75455205
66Spastic gait (HP:0002064)2.74813970
67Intention tremor (HP:0002080)2.74202708
68Short nail (HP:0001799)2.72620114
69Fetal akinesia sequence (HP:0001989)2.71073358
70Abnormal eating behavior (HP:0100738)2.69489769
71Abnormal hand bone ossification (HP:0010660)2.68464111
72Focal dystonia (HP:0004373)2.66446589
73Dysdiadochokinesis (HP:0002075)2.66234697
74Supernumerary bones of the axial skeleton (HP:0009144)2.65157376
75Basal cell carcinoma (HP:0002671)2.64465480
76Rapidly progressive (HP:0003678)2.63159720
77Sensory axonal neuropathy (HP:0003390)2.58973817
78Truncal ataxia (HP:0002078)2.56453808
79Craniofacial dystonia (HP:0012179)2.54507364
80Alkalosis (HP:0001948)2.51612081
81Megalencephaly (HP:0001355)2.51132160
82Pointed chin (HP:0000307)2.48292083
83Hypokalemic alkalosis (HP:0001949)2.47563497
84Resting tremor (HP:0002322)2.46185589
85Bradykinesia (HP:0002067)2.44257200
86Hyperacusis (HP:0010780)2.43014759
87Lower limb muscle weakness (HP:0007340)2.39613569
88Exercise-induced muscle cramps (HP:0003710)2.37611763
89Reduced subcutaneous adipose tissue (HP:0003758)2.37284778
90Prominent nose (HP:0000448)2.35627842
91Dysmetric saccades (HP:0000641)2.35524675
92Peripheral hypomyelination (HP:0007182)2.34691191
93Pheochromocytoma (HP:0002666)2.33267472
94Colitis (HP:0002583)2.32292519
95Osteolytic defects of the phalanges of the hand (HP:0009771)2.29535583
96Osteolytic defects of the hand bones (HP:0009699)2.29535583
97Scanning speech (HP:0002168)2.28575296
98Genetic anticipation (HP:0003743)2.28218730
99Calf muscle hypertrophy (HP:0008981)2.25443897
100Neuronal loss in central nervous system (HP:0002529)2.24167228
101Amblyopia (HP:0000646)2.24133924
102Clonus (HP:0002169)2.23152835
103Abnormality of the calf musculature (HP:0001430)2.21654412
104Tubular atrophy (HP:0000092)2.21331321
105Rhabdomyolysis (HP:0003201)2.20869202
106Diplopia (HP:0000651)2.20050845
107Abnormality of binocular vision (HP:0011514)2.20050845
108Apathy (HP:0000741)2.18757826
109Broad-based gait (HP:0002136)2.18649051
110Gaze-evoked nystagmus (HP:0000640)2.18126313
111Heterotopia (HP:0002282)2.17651081
112Menstrual irregularities (HP:0000858)2.16454603
113Hamartoma (HP:0010566)2.16408602
114Abnormal atrioventricular conduction (HP:0005150)2.16273523
115Paralysis (HP:0003470)2.15317999
116Impaired smooth pursuit (HP:0007772)2.13956048
117Abnormality of the corticospinal tract (HP:0002492)2.13348365
118Hypercortisolism (HP:0001578)2.13159454
119Cerebellar dysplasia (HP:0007033)2.11795877
120EMG: myopathic abnormalities (HP:0003458)2.11384684
121Limb dystonia (HP:0002451)2.10591554
122Mild short stature (HP:0003502)2.10566812
123Upper limb amyotrophy (HP:0009129)2.09961751
124Distal upper limb amyotrophy (HP:0007149)2.09961751
125Progressive inability to walk (HP:0002505)2.09304950
126Abnormal EKG (HP:0003115)2.08710032
127Lower limb amyotrophy (HP:0007210)2.08072731
128Rigidity (HP:0002063)2.07945545
129Abnormality of DNA repair (HP:0003254)2.07311368
130Stereotypic behavior (HP:0000733)2.06950124
131Hemiparesis (HP:0001269)2.06097569
132Duplicated collecting system (HP:0000081)2.05848311
133Ureteral duplication (HP:0000073)2.04385407
134Onion bulb formation (HP:0003383)2.02090358
135Abnormality of nail color (HP:0100643)2.00886174
136Distal lower limb amyotrophy (HP:0008944)2.00673300
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00483859
138Abnormality of the left ventricular outflow tract (HP:0011103)2.00399848
139Subaortic stenosis (HP:0001682)2.00399848
140Flattened epiphyses (HP:0003071)2.00352743
141Prolonged QT interval (HP:0001657)1.99617765
142Hammertoe (HP:0001765)1.98919835
143Overriding aorta (HP:0002623)1.98128902
144Broad face (HP:0000283)1.97792784
145Partial agenesis of the corpus callosum (HP:0001338)1.97391880
146Elfin facies (HP:0004428)1.95603899
147Decreased lacrimation (HP:0000633)1.95439113
148Diminished motivation (HP:0000745)1.94923820
149Neoplasm of the peripheral nervous system (HP:0100007)1.94280408
150Ventricular arrhythmia (HP:0004308)1.94185741
151Lipoatrophy (HP:0100578)1.94041531
152Atrial fibrillation (HP:0005110)1.93681096
153Interstitial pulmonary disease (HP:0006530)1.93330867
154Abnormality of saccadic eye movements (HP:0000570)1.91797857
155Impaired vibratory sensation (HP:0002495)1.91050952
156Ankyloglossia (HP:0010296)1.89430460
157Neuroendocrine neoplasm (HP:0100634)1.87228957
158Achilles tendon contracture (HP:0001771)1.87035469
159Status epilepticus (HP:0002133)1.86487390
160Abnormality of ocular smooth pursuit (HP:0000617)1.86469418
161Sudden death (HP:0001699)1.86099311
162Anosmia (HP:0000458)1.84979904
163Muscle hypertrophy of the lower extremities (HP:0008968)1.84183682
164Dilated cardiomyopathy (HP:0001644)1.83980307
165Poikiloderma (HP:0001029)1.83639570
166Syncope (HP:0001279)1.82419692
167Heart block (HP:0012722)1.81957490
168Neoplasm of the heart (HP:0100544)1.81921338
169Abnormality of the periventricular white matter (HP:0002518)1.81765760
170Skin pits (HP:0100276)1.81580677
171Lower limb asymmetry (HP:0100559)1.81155414
172Macroorchidism (HP:0000053)1.80970434
173Muscle fiber splitting (HP:0003555)1.80873088
174Postural tremor (HP:0002174)1.80127686
175Hypoplasia of the iris (HP:0007676)1.79531889
176Agitation (HP:0000713)1.78928491
177Nemaline bodies (HP:0003798)1.78830381
178Tetany (HP:0001281)1.78771537
179Abnormality of cochlea (HP:0000375)1.78229213
180Abnormality of the renal collecting system (HP:0004742)1.75701525
181Deep philtrum (HP:0002002)1.75176691
182Fair hair (HP:0002286)1.74283310
183Muscular dystrophy (HP:0003560)1.74107093
184Natal tooth (HP:0000695)1.72956029
185Abnormality of the epiphyses of the hand (HP:0005924)1.70377644
186Blue irides (HP:0000635)1.70258542
187Progressive sensorineural hearing impairment (HP:0000408)1.70217762
188EMG: neuropathic changes (HP:0003445)1.70184334
189Truncal obesity (HP:0001956)1.69617118
190Decreased motor nerve conduction velocity (HP:0003431)1.69297309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.28571429
2STK394.25654375
3NTRK33.69259288
4EPHA43.21534429
5KSR22.98168451
6OXSR12.95028663
7NEK92.71561413
8PRKD32.68626325
9MST1R2.66534573
10MINK12.60056985
11ZAK2.53327001
12TLK12.51615168
13PAK62.47599358
14MARK12.42733172
15MAP3K42.42143139
16NTRK12.33674622
17DAPK22.32780925
18OBSCN2.20449129
19CAMKK12.17918051
20LMTK22.01528246
21PDK22.00932860
22STK381.75928736
23MAP3K21.75481452
24NTRK21.74551518
25MAP2K41.61548119
26PHKG21.57208935
27PHKG11.57208935
28TRIB31.52086946
29ALK1.48360320
30EPHA31.46465900
31RPS6KA51.45768959
32TYRO31.45064672
33CDK51.44178681
34TAOK11.41087217
35MAP2K71.38160984
36LATS21.31733774
37RET1.31280573
38GRK51.29260390
39RIPK41.28777306
40UHMK11.28086630
41MAP3K121.27337751
42PDGFRB1.26148949
43RIPK11.25126410
44SIK21.24081154
45PRKCH1.23815967
46NEK11.20590879
47ARAF1.20178569
48FES1.19175691
49KSR11.17321394
50MAP3K131.11525267
51DAPK11.10528967
52ABL21.08897950
53MAPKAPK51.07448857
54MET1.06124283
55TTN1.04769592
56NEK61.03921991
57PKN21.03609294
58MAP3K61.02898975
59HCK1.00260463
60PINK11.00166745
61RPS6KB20.98620624
62CDC70.97661744
63STK110.97481691
64MAP3K10.95370547
65WNK10.94037266
66PAK30.93972038
67PKN10.90813193
68CDK190.88694251
69TRPM70.87523906
70PBK0.87391775
71MARK20.86337412
72SCYL20.86315296
73SGK2230.85821015
74SGK4940.85821015
75CAMK10.85161337
76PRKCG0.85028363
77PDPK10.83838469
78CCNB10.83036024
79PRKAA20.81735107
80PDK10.80893426
81MAP3K70.80420464
82CDK150.79451765
83CDC42BPA0.78938437
84TNK20.78079765
85CDK140.76553730
86SGK30.76103095
87CDK180.75810284
88PDGFRA0.75523508
89CAMKK20.74916964
90MAPK120.73969181
91ICK0.73632585
92CDK120.72016209
93CDK11A0.69224452
94BMX0.68589966
95MAPK110.67220876
96LIMK10.66558793
97RAF10.64793507
98CAMK2B0.64100354
99CDK60.64083987
100CAMK2A0.62522541
101DMPK0.62468632
102PRKAA10.62053468
103FGFR30.60915269
104MAPK130.59153729
105FER0.59025717
106PNCK0.59015627
107PLK20.58248224
108BLK0.57708776
109PTK2B0.57395408
110PRPF4B0.56724300
111CAMK1G0.56618809
112STK40.55582074
113AURKB0.55362213
114MAP2K10.54512676
115DAPK30.54186543
116RPS6KA20.53690426
117SGK10.53331277
118BTK0.52874628
119FYN0.52511487
120AURKA0.51815652
121MUSK0.50883084
122CAMK2G0.50237260
123PRKD10.49969783
124PRKG20.49629009
125CSNK1G20.49532064
126PRKCZ0.49500181
127AKT30.49478389
128RPS6KA30.49437916
129MAPK100.48127975
130DDR20.47442939
131WNK40.47183149
132ROCK20.46373610
133CAMK40.44755016
134BRSK10.44704840
135CAMK2D0.43406351
136RPS6KB10.42925075
137SGK20.41294566
138EEF2K0.40970002
139MTOR0.40647762
140ROCK10.40415744
141JAK20.38336183
142CAMK1D0.35463575
143AKT20.32402231
144RPS6KA40.32195523
145BRD40.31878873
146PIM10.28933903
147NME20.28708235
148MAPK40.27498026
149NLK0.26375457
150VRK10.25974524
151LATS10.25473853
152BRAF0.25161214
153MAPK90.24963933
154MAP3K80.23051755
155EPHA20.22635681
156JAK10.20039545
157MAPKAPK30.19858881
158CDK70.18321262

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053226.00336289
2Alcoholism_Homo sapiens_hsa050344.35320326
3Synaptic vesicle cycle_Homo sapiens_hsa047213.02217562
4Olfactory transduction_Homo sapiens_hsa047403.02162672
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.54210407
6Nitrogen metabolism_Homo sapiens_hsa009102.43759395
7Nicotine addiction_Homo sapiens_hsa050332.40482825
8GABAergic synapse_Homo sapiens_hsa047272.33195802
9Circadian entrainment_Homo sapiens_hsa047132.26379471
10Long-term potentiation_Homo sapiens_hsa047202.18137908
11Glutamatergic synapse_Homo sapiens_hsa047242.06477019
12Morphine addiction_Homo sapiens_hsa050322.03354778
13Ovarian steroidogenesis_Homo sapiens_hsa049131.99333817
14Salivary secretion_Homo sapiens_hsa049701.98213348
15Gastric acid secretion_Homo sapiens_hsa049711.96572827
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93765877
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.93021820
18Amphetamine addiction_Homo sapiens_hsa050311.89912483
19Dopaminergic synapse_Homo sapiens_hsa047281.84475783
20Insulin secretion_Homo sapiens_hsa049111.81262061
21Viral carcinogenesis_Homo sapiens_hsa052031.79003964
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77982578
23Cholinergic synapse_Homo sapiens_hsa047251.70900415
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66635073
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61112112
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60694888
27Oxytocin signaling pathway_Homo sapiens_hsa049211.46418640
28Cocaine addiction_Homo sapiens_hsa050301.43523506
29Renin secretion_Homo sapiens_hsa049241.42902042
30GnRH signaling pathway_Homo sapiens_hsa049121.42136377
31Type II diabetes mellitus_Homo sapiens_hsa049301.33378378
32Gap junction_Homo sapiens_hsa045401.32859521
33Taste transduction_Homo sapiens_hsa047421.30498980
34Long-term depression_Homo sapiens_hsa047301.25186342
35Calcium signaling pathway_Homo sapiens_hsa040201.25172423
36Glioma_Homo sapiens_hsa052141.23815975
37Estrogen signaling pathway_Homo sapiens_hsa049151.23784715
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23192678
39Insulin resistance_Homo sapiens_hsa049311.22778781
40cAMP signaling pathway_Homo sapiens_hsa040241.21736302
41ABC transporters_Homo sapiens_hsa020101.18077096
42Pancreatic cancer_Homo sapiens_hsa052121.17579777
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15731070
44Dorso-ventral axis formation_Homo sapiens_hsa043201.15059281
45Non-homologous end-joining_Homo sapiens_hsa034501.11945573
46Small cell lung cancer_Homo sapiens_hsa052221.09578980
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07734969
48Serotonergic synapse_Homo sapiens_hsa047261.05660840
49ECM-receptor interaction_Homo sapiens_hsa045121.00832720
50ErbB signaling pathway_Homo sapiens_hsa040120.98653394
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.98455371
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98344392
53Axon guidance_Homo sapiens_hsa043600.94946549
54Melanogenesis_Homo sapiens_hsa049160.94701659
55Dilated cardiomyopathy_Homo sapiens_hsa054140.94697138
56Colorectal cancer_Homo sapiens_hsa052100.94284825
57DNA replication_Homo sapiens_hsa030300.93337132
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.90312151
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89967465
60Collecting duct acid secretion_Homo sapiens_hsa049660.89137917
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88666506
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88516775
63Thyroid hormone synthesis_Homo sapiens_hsa049180.87357357
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.87123958
65VEGF signaling pathway_Homo sapiens_hsa043700.86355557
66Bile secretion_Homo sapiens_hsa049760.86008304
67mTOR signaling pathway_Homo sapiens_hsa041500.85695286
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84274377
69Pancreatic secretion_Homo sapiens_hsa049720.81809499
70Endocytosis_Homo sapiens_hsa041440.81128171
71Focal adhesion_Homo sapiens_hsa045100.78373411
72Oocyte meiosis_Homo sapiens_hsa041140.77276056
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75891200
74Cardiac muscle contraction_Homo sapiens_hsa042600.75571173
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72113648
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71938009
77Choline metabolism in cancer_Homo sapiens_hsa052310.68338338
78MAPK signaling pathway_Homo sapiens_hsa040100.67935400
79Vibrio cholerae infection_Homo sapiens_hsa051100.67898105
80Insulin signaling pathway_Homo sapiens_hsa049100.67865701
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67365396
82Rap1 signaling pathway_Homo sapiens_hsa040150.66747316
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66187018
84Viral myocarditis_Homo sapiens_hsa054160.65571393
85Endometrial cancer_Homo sapiens_hsa052130.64753283
86Non-small cell lung cancer_Homo sapiens_hsa052230.63841776
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63718807
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.63615623
89Renal cell carcinoma_Homo sapiens_hsa052110.61484368
90FoxO signaling pathway_Homo sapiens_hsa040680.59938234
91Biosynthesis of amino acids_Homo sapiens_hsa012300.59099448
92Glucagon signaling pathway_Homo sapiens_hsa049220.58980514
93Pathways in cancer_Homo sapiens_hsa052000.58562457
94Lysine degradation_Homo sapiens_hsa003100.58192280
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58021306
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56364867
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56347807
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.55703915
99Inositol phosphate metabolism_Homo sapiens_hsa005620.55343790
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55095551
101Chronic myeloid leukemia_Homo sapiens_hsa052200.54528333
102HIF-1 signaling pathway_Homo sapiens_hsa040660.54474428
103Prion diseases_Homo sapiens_hsa050200.54350631
104Ras signaling pathway_Homo sapiens_hsa040140.53926473
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53494661
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53178038
107Arginine biosynthesis_Homo sapiens_hsa002200.52867208
108Pentose phosphate pathway_Homo sapiens_hsa000300.52634029
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51461761
110Hedgehog signaling pathway_Homo sapiens_hsa043400.48724290
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45999440
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45709626
113Chemokine signaling pathway_Homo sapiens_hsa040620.45362715
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44723292
115AMPK signaling pathway_Homo sapiens_hsa041520.44391822
116Platelet activation_Homo sapiens_hsa046110.44350287
117Basal cell carcinoma_Homo sapiens_hsa052170.43689308
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42555904
119Tight junction_Homo sapiens_hsa045300.42185886
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38963756
121Acute myeloid leukemia_Homo sapiens_hsa052210.38868293
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38577199
123Circadian rhythm_Homo sapiens_hsa047100.38497436
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38157590
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.36793723
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36668648
127Fatty acid biosynthesis_Homo sapiens_hsa000610.36426688
128Prolactin signaling pathway_Homo sapiens_hsa049170.35952086
129Fatty acid metabolism_Homo sapiens_hsa012120.35708655
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35636240
131Purine metabolism_Homo sapiens_hsa002300.35522457
132B cell receptor signaling pathway_Homo sapiens_hsa046620.34761188
133Type I diabetes mellitus_Homo sapiens_hsa049400.32859621
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32253449
135Amoebiasis_Homo sapiens_hsa051460.31649670
136Carbon metabolism_Homo sapiens_hsa012000.28283906

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