EML4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)7.21553228
2plasma lipoprotein particle assembly (GO:0034377)6.97694268
3protein-lipid complex assembly (GO:0065005)6.14555206
4negative regulation of fibrinolysis (GO:0051918)5.67072266
5low-density lipoprotein particle remodeling (GO:0034374)5.63416789
6nuclear pore complex assembly (GO:0051292)5.55519798
7regulation of apoptotic cell clearance (GO:2000425)5.31702545
8nuclear pore organization (GO:0006999)5.24276333
9regulation of fibrinolysis (GO:0051917)5.19234563
10regulation of protein activation cascade (GO:2000257)5.11879786
11regulation of complement activation (GO:0030449)5.07512854
12DNA unwinding involved in DNA replication (GO:0006268)4.98258201
13cholesterol efflux (GO:0033344)4.92546254
14intestinal cholesterol absorption (GO:0030299)4.88794697
15plasma lipoprotein particle organization (GO:0071827)4.76135733
16mitotic sister chromatid cohesion (GO:0007064)4.64507133
17regulation of cholesterol esterification (GO:0010872)4.57282787
18macromolecular complex remodeling (GO:0034367)4.48934010
19plasma lipoprotein particle remodeling (GO:0034369)4.48934010
20protein-lipid complex remodeling (GO:0034368)4.48934010
21protein-lipid complex subunit organization (GO:0071825)4.44214943
22pre-miRNA processing (GO:0031054)4.35990387
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.35635942
24negative regulation of protein activation cascade (GO:2000258)4.28190886
25protein carboxylation (GO:0018214)4.27260477
26peptidyl-glutamic acid carboxylation (GO:0017187)4.27260477
27negative regulation of histone methylation (GO:0031061)4.16433470
28protein localization to kinetochore (GO:0034501)4.11460343
29pore complex assembly (GO:0046931)4.09748792
30regulation of histone H3-K9 methylation (GO:0051570)3.99142691
31positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.98603865
32intestinal absorption (GO:0050892)3.98411079
33high-density lipoprotein particle remodeling (GO:0034375)3.96218814
34plasma lipoprotein particle clearance (GO:0034381)3.92979332
35reverse cholesterol transport (GO:0043691)3.81520630
36blood coagulation, intrinsic pathway (GO:0007597)3.79549406
37mitotic nuclear envelope disassembly (GO:0007077)3.78925849
38regulation of bile acid biosynthetic process (GO:0070857)3.75345721
39mitotic chromosome condensation (GO:0007076)3.74019548
40DNA duplex unwinding (GO:0032508)3.68796151
41regulation of sister chromatid cohesion (GO:0007063)3.68344884
42DNA geometric change (GO:0032392)3.67461684
43regulation of RNA export from nucleus (GO:0046831)3.67352119
44negative regulation of complement activation (GO:0045916)3.65753129
45heterochromatin organization (GO:0070828)3.65721152
46lipoprotein metabolic process (GO:0042157)3.63095548
47regulation of cholesterol homeostasis (GO:2000188)3.58110073
48phospholipid efflux (GO:0033700)3.56126664
49nuclear envelope disassembly (GO:0051081)3.54984580
50membrane disassembly (GO:0030397)3.54984580
51dosage compensation (GO:0007549)3.51204606
52COPII vesicle coating (GO:0048208)3.49411643
53sister chromatid segregation (GO:0000819)3.48081742
54regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.46931867
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43578918
56complement activation, alternative pathway (GO:0006957)3.40903689
57negative regulation of RNA splicing (GO:0033119)3.38325351
58protein localization to chromosome, centromeric region (GO:0071459)3.37382328
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35967165
60kinetochore organization (GO:0051383)3.34711565
61chromatin assembly (GO:0031497)3.33099599
62DNA replication-dependent nucleosome assembly (GO:0006335)3.29526896
63DNA replication-dependent nucleosome organization (GO:0034723)3.29526896
64negative regulation of DNA repair (GO:0045738)3.27948797
65mRNA stabilization (GO:0048255)3.27790686
66RNA stabilization (GO:0043489)3.27790686
67negative regulation of cholesterol transport (GO:0032375)3.25927446
68negative regulation of sterol transport (GO:0032372)3.25927446
69mitotic metaphase plate congression (GO:0007080)3.23668504
70DNA replication initiation (GO:0006270)3.20621946
71regulation of posttranscriptional gene silencing (GO:0060147)3.20007546
72regulation of gene silencing by miRNA (GO:0060964)3.20007546
73regulation of gene silencing by RNA (GO:0060966)3.20007546
74IMP biosynthetic process (GO:0006188)3.18669679
75metaphase plate congression (GO:0051310)3.17822708
76positive regulation of extracellular matrix organization (GO:1903055)3.15042121
77folic acid-containing compound biosynthetic process (GO:0009396)3.14709871
78DNA strand elongation involved in DNA replication (GO:0006271)3.14077499
79mitotic sister chromatid segregation (GO:0000070)3.12969092
80embryonic process involved in female pregnancy (GO:0060136)3.10660335
81histone H2A monoubiquitination (GO:0035518)3.08976941
82regulation of humoral immune response (GO:0002920)3.08743400
83positive regulation of hormone biosynthetic process (GO:0046886)3.07236032
84DNA topological change (GO:0006265)3.04780010
85regulation of spindle organization (GO:0090224)3.04597639
86cholesterol transport (GO:0030301)3.04488649
87sterol transport (GO:0015918)3.04488649
88chromatin assembly or disassembly (GO:0006333)3.04429154
89cholesterol homeostasis (GO:0042632)3.01790865
90regulation of DNA endoreduplication (GO:0032875)3.01191105
91sterol homeostasis (GO:0055092)3.00730761
92DNA conformation change (GO:0071103)2.99236415
93DNA strand elongation (GO:0022616)2.98919519
94regulation of plasminogen activation (GO:0010755)2.97902256
95positive regulation of mitotic sister chromatid separation (GO:1901970)2.97022675
96positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.97022675
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.97022675
98alternative mRNA splicing, via spliceosome (GO:0000380)2.96996058
99negative regulation of histone modification (GO:0031057)2.95855066
100negative regulation of mRNA processing (GO:0050686)2.95406412
101somatic hypermutation of immunoglobulin genes (GO:0016446)2.95323592
102somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95323592
103response to interleukin-15 (GO:0070672)2.94240358
104translesion synthesis (GO:0019985)2.93947739
105meiotic chromosome segregation (GO:0045132)2.92718709
106ribosomal small subunit assembly (GO:0000028)2.92292517
107embryonic retina morphogenesis in camera-type eye (GO:0060059)2.92209766
108formation of translation preinitiation complex (GO:0001731)2.91472675
109acute-phase response (GO:0006953)2.91151883
110nucleotide-sugar biosynthetic process (GO:0009226)2.90478227
111positive regulation of hormone metabolic process (GO:0032352)2.89214546
112regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.87587774
113positive regulation of chromosome segregation (GO:0051984)2.87102434
114low-density lipoprotein particle clearance (GO:0034383)2.86625583
115protein localization to chromosome (GO:0034502)2.86017976
116negative regulation of chromatin modification (GO:1903309)2.85821799
117mitotic recombination (GO:0006312)2.85682358
118IMP metabolic process (GO:0046040)2.84639541
119gene silencing by RNA (GO:0031047)2.84393426
120diacylglycerol metabolic process (GO:0046339)2.82991429
121complement activation, classical pathway (GO:0006958)2.82525003
122regulation of non-canonical Wnt signaling pathway (GO:2000050)2.81885599
123ATP-dependent chromatin remodeling (GO:0043044)2.81588535
124regulation of centriole replication (GO:0046599)2.81318359
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81190206
126DNA replication-independent nucleosome organization (GO:0034724)2.80665965
127DNA replication-independent nucleosome assembly (GO:0006336)2.80665965
128mRNA transport (GO:0051028)2.80420072
129maturation of SSU-rRNA (GO:0030490)2.79851953
130establishment of chromosome localization (GO:0051303)2.79364991
131protein activation cascade (GO:0072376)2.79348207
132regulation of nucleobase-containing compound transport (GO:0032239)2.78465589
133attachment of spindle microtubules to kinetochore (GO:0008608)2.78005193
134regulation of helicase activity (GO:0051095)2.77533511
135regulation of translational fidelity (GO:0006450)2.77235603
136nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.77134818
137regulation of chromosome segregation (GO:0051983)2.76149916
138regulation of mRNA stability (GO:0043488)2.75451186
139histone mRNA catabolic process (GO:0071044)2.75380729
140negative regulation of humoral immune response (GO:0002921)2.75084132
141negative regulation of mRNA metabolic process (GO:1903312)2.75004492
142positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.74968074
1433-UTR-mediated mRNA stabilization (GO:0070935)2.74904172
144glucocorticoid receptor signaling pathway (GO:0042921)2.74433525
145positive regulation of steroid metabolic process (GO:0045940)2.74217153
146telomere maintenance via semi-conservative replication (GO:0032201)2.74193160
147chromatin remodeling at centromere (GO:0031055)2.74070253
148sister chromatid cohesion (GO:0007062)2.73211804
149pinocytosis (GO:0006907)2.72007662
150nucleobase biosynthetic process (GO:0046112)2.70523300
151regulation of mitotic spindle organization (GO:0060236)2.68518616
152nuclear envelope organization (GO:0006998)2.68023210
153telomere maintenance via recombination (GO:0000722)2.66458572
154trivalent inorganic anion homeostasis (GO:0072506)2.66226663
155phosphate ion homeostasis (GO:0055062)2.66226663
156monoubiquitinated protein deubiquitination (GO:0035520)2.66147209
157phospholipid scrambling (GO:0017121)2.66035558
158vitamin transmembrane transport (GO:0035461)2.65999662
159negative regulation of norepinephrine secretion (GO:0010700)2.64865820
160regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64822655
161regulation of extracellular matrix organization (GO:1903053)2.63769397
162spindle checkpoint (GO:0031577)2.63576826
163regulation of gene silencing (GO:0060968)2.62632592
164spindle assembly checkpoint (GO:0071173)2.62127737
165fibrinolysis (GO:0042730)2.62111503
166kinetochore assembly (GO:0051382)2.61984870
167RNA export from nucleus (GO:0006405)2.61526321
168L-phenylalanine catabolic process (GO:0006559)2.60711276
169erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60711276
170CENP-A containing nucleosome assembly (GO:0034080)2.60447744
171transepithelial transport (GO:0070633)2.58813934
172cell proliferation involved in kidney development (GO:0072111)2.55913345
173positive regulation of hemostasis (GO:1900048)2.55849576
174positive regulation of blood coagulation (GO:0030194)2.55849576
175regulation of cholesterol biosynthetic process (GO:0045540)2.51958287
176regulation of cytokine secretion involved in immune response (GO:0002739)2.51624974
177female gonad development (GO:0008585)2.51088964
178erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.49553254
179L-phenylalanine metabolic process (GO:0006558)2.49553254
180mesenchymal cell proliferation (GO:0010463)2.49334585
181cellular response to ethanol (GO:0071361)2.48982508
182negative regulation of hemostasis (GO:1900047)2.48815546
183negative regulation of blood coagulation (GO:0030195)2.48815546
184lipoprotein transport (GO:0042953)2.48561082
185regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.46270270
186hepatocyte apoptotic process (GO:0097284)2.44815447
187lipid homeostasis (GO:0055088)2.44452509
188negative regulation of coagulation (GO:0050819)2.38153930
189phospholipid homeostasis (GO:0055091)2.36715946
190pathway-restricted SMAD protein phosphorylation (GO:0060389)2.35836180
191positive regulation of coagulation (GO:0050820)2.35241544
192mRNA modification (GO:0016556)2.35189127
193regulation of metalloenzyme activity (GO:0048552)2.34715667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.55006957
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.37346631
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.94575847
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.84380468
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.41312587
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25328586
7MYC_22102868_ChIP-Seq_BL_Human3.07766788
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.91961963
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.76588450
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63187099
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61092124
12* FOXA2_19822575_ChIP-Seq_HepG2_Human2.59125265
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.46274090
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.45755578
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.42007205
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32294836
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.28863042
18* LXR_22158963_ChIP-Seq_LIVER_Mouse2.28538386
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25920797
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.24931571
21RXR_22158963_ChIP-Seq_LIVER_Mouse2.17178410
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17024239
23AR_21909140_ChIP-Seq_LNCAP_Human2.14105343
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12607330
25* SALL4_18804426_ChIP-ChIP_XEN_Mouse2.03763117
26E2F7_22180533_ChIP-Seq_HELA_Human11.2283360
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97543469
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.93860363
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92353152
30CIITA_25753668_ChIP-Seq_RAJI_Human1.89146053
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87777800
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87655761
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.86025253
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81659867
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81118537
36XRN2_22483619_ChIP-Seq_HELA_Human1.73168817
37* FOXO3_23340844_ChIP-Seq_DLD1_Human1.73085927
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70631536
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69572374
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59977892
41* TCF4_18268006_ChIP-ChIP_LS174T_Human1.56670254
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55779533
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.55122206
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54404445
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54320013
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53748671
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52423819
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51120389
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50247596
50GATA4_25053715_ChIP-Seq_YYC3_Human1.48895634
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48400552
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48400552
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48400552
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45501627
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44336813
56VDR_21846776_ChIP-Seq_THP-1_Human1.43513032
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42128246
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40333443
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37795343
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37230489
61KDM5A_27292631_Chip-Seq_BREAST_Human1.34236300
62TCF7_22412390_ChIP-Seq_EML_Mouse1.34070862
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33833592
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.33556129
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32673187
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32325959
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32231421
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32117754
69FOXP3_21729870_ChIP-Seq_TREG_Human1.32030707
70ELK1_19687146_ChIP-ChIP_HELA_Human1.31839092
71GATA6_25053715_ChIP-Seq_YYC3_Human1.31571412
72CLOCK_20551151_ChIP-Seq_293T_Human1.31066083
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.29602570
74VDR_23849224_ChIP-Seq_CD4+_Human1.29100913
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28074639
76TTF2_22483619_ChIP-Seq_HELA_Human1.27979208
77* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27877952
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27564996
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27249742
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.27171756
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27170220
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26909837
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26267655
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25050610
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.24796384
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24699352
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23405102
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23404416
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23304928
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22899642
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20890526
92RUNX_20019798_ChIP-Seq_JUKART_Human1.19640630
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18430222
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17316942
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15885568
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15124510
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15072518
98UTX_26944678_Chip-Seq_JUKART_Human1.14856614
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.14852900
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14805174
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14254613
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13884686
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13317895
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11776163
105PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10566096
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10335942
107MYB_26560356_Chip-Seq_TH2_Human1.09488142
108MYB_26560356_Chip-Seq_TH1_Human1.08835966
109HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07956270
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06615043
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06592416
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06358195
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05944381
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04453270
115* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04271669
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.03209799
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02587083
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02360272
119TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01348329
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01326196
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01076533
122TFEB_21752829_ChIP-Seq_HELA_Human1.00974546
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00959837
124CDX2_22108803_ChIP-Seq_LS180_Human1.00553614
125MAF_26560356_Chip-Seq_TH1_Human1.00255114
126WT1_19549856_ChIP-ChIP_CCG9911_Human1.00058129
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99304028
128MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98983540
129* NANOG_21062744_ChIP-ChIP_HESCs_Human0.98887291
130* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98221106
131CHD1_26751641_Chip-Seq_LNCaP_Human0.97940792
132CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97932091
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97288765
134TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96959389
135SCL_19346495_ChIP-Seq_HPC-7_Human0.96197071
136* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96159652
137STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95154208
138* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94879970
139* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94485759
140IRF8_27001747_Chip-Seq_BMDM_Mouse0.93718188
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93251035
142* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92962422
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92830720
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92617584
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92010804
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91755473
147GABP_19822575_ChIP-Seq_HepG2_Human0.91148305
148SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91078010
149SPI1_23547873_ChIP-Seq_NB4_Human0.91025094
150E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90118909
151SOX17_20123909_ChIP-Seq_XEN_Mouse0.89965048
152HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89417204
153* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88945194
154PU_27001747_Chip-Seq_BMDM_Mouse0.88581965
155* SOX2_20726797_ChIP-Seq_SW620_Human0.88496876
156DCP1A_22483619_ChIP-Seq_HELA_Human0.88178475
157FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88148656
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88133649
159OCT4_18555785_Chip-Seq_ESCs_Mouse0.88070383
160STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87707463
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87167787
162GATA3_27048872_Chip-Seq_THYMUS_Human0.86953509
163CRX_20693478_ChIP-Seq_RETINA_Mouse0.86739498
164ETS1_20019798_ChIP-Seq_JURKAT_Human0.86721964
165OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86385781
166* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86114364
167ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86090178
168MYC_18940864_ChIP-ChIP_HL60_Human0.85344687
169* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83937934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.48094449
2MP0002139_abnormal_hepatobiliary_system4.05678969
3MP0010094_abnormal_chromosome_stability3.40853227
4MP0008057_abnormal_DNA_replication3.38230166
5MP0003123_paternal_imprinting3.23041051
6MP0005365_abnormal_bile_salt3.20925968
7MP0001666_abnormal_nutrient_absorption3.09696880
8MP0003693_abnormal_embryo_hatching3.09361598
9MP0003077_abnormal_cell_cycle3.01242237
10MP0003111_abnormal_nucleus_morphology2.96750185
11MP0004957_abnormal_blastocyst_morpholog2.87652295
12MP0010352_gastrointestinal_tract_polyps2.78294935
13MP0005360_urolithiasis2.71591400
14MP0003121_genomic_imprinting2.54509218
15MP0008877_abnormal_DNA_methylation2.21304454
16MP0002396_abnormal_hematopoietic_system2.18934905
17MP0010234_abnormal_vibrissa_follicle2.17676345
18MP0002254_reproductive_system_inflammat2.14816196
19MP0005085_abnormal_gallbladder_physiolo2.13616721
20MP0000537_abnormal_urethra_morphology2.12371352
21MP0008058_abnormal_DNA_repair2.09810871
22MP0005076_abnormal_cell_differentiation2.07783668
23MP0010329_abnormal_lipoprotein_level2.07769890
24MP0009053_abnormal_anal_canal2.00733350
25MP0000350_abnormal_cell_proliferation1.99797699
26MP0004808_abnormal_hematopoietic_stem1.94432391
27MP0008007_abnormal_cellular_replicative1.93865200
28MP0001730_embryonic_growth_arrest1.93158365
29MP0005408_hypopigmentation1.89243200
30MP0003868_abnormal_feces_composition1.88865804
31MP0003252_abnormal_bile_duct1.88112741
32MP0010307_abnormal_tumor_latency1.86996151
33MP0000569_abnormal_digit_pigmentation1.85650999
34MP0004197_abnormal_fetal_growth/weight/1.80737902
35MP0005380_embryogenesis_phenotype1.73804176
36MP0001672_abnormal_embryogenesis/_devel1.73804176
37MP0002084_abnormal_developmental_patter1.72668207
38MP0003787_abnormal_imprinting1.72187876
39MP0003172_abnormal_lysosome_physiology1.69865825
40MP0002086_abnormal_extraembryonic_tissu1.67255075
41MP0003567_abnormal_fetal_cardiomyocyte1.63769470
42MP0003984_embryonic_growth_retardation1.62487997
43MP0002088_abnormal_embryonic_growth/wei1.62098027
44MP0001697_abnormal_embryo_size1.61814380
45MP0009697_abnormal_copulation1.61254480
46MP0002085_abnormal_embryonic_tissue1.61075337
47MP0003705_abnormal_hypodermis_morpholog1.60056215
48MP0008932_abnormal_embryonic_tissue1.54437281
49MP0003890_abnormal_embryonic-extraembry1.53525075
50MP0001293_anophthalmia1.41849775
51MP0003950_abnormal_plasma_membrane1.40444389
52MP0000609_abnormal_liver_physiology1.39542999
53MP0003941_abnormal_skin_development1.38171748
54MP0002933_joint_inflammation1.37963161
55MP0000490_abnormal_crypts_of1.37390992
56MP0002080_prenatal_lethality1.33599094
57MP0006054_spinal_hemorrhage1.32795852
58MP0003763_abnormal_thymus_physiology1.32620361
59MP0010030_abnormal_orbit_morphology1.31468319
60MP0002089_abnormal_postnatal_growth/wei1.29901955
61MP0008875_abnormal_xenobiotic_pharmacok1.27573347
62MP0003119_abnormal_digestive_system1.26580831
63MP0009278_abnormal_bone_marrow1.26245493
64MP0004264_abnormal_extraembryonic_tissu1.25337449
65MP0002009_preneoplasia1.23543749
66MP0003122_maternal_imprinting1.23530354
67MP0003937_abnormal_limbs/digits/tail_de1.22039990
68MP0000703_abnormal_thymus_morphology1.19994857
69MP0002398_abnormal_bone_marrow1.19842838
70MP0002138_abnormal_hepatobiliary_system1.19514484
71MP0003115_abnormal_respiratory_system1.18662689
72MP0003385_abnormal_body_wall1.17238329
73MP0000516_abnormal_urinary_system1.15276571
74MP0005367_renal/urinary_system_phenotyp1.15276571
75MP0001800_abnormal_humoral_immune1.10198239
76MP0002019_abnormal_tumor_incidence1.09835105
77MP0009703_decreased_birth_body1.09338660
78MP0000313_abnormal_cell_death1.05730072
79MP0003935_abnormal_craniofacial_develop1.05458736
80MP0001915_intracranial_hemorrhage1.05256609
81MP0000428_abnormal_craniofacial_morphol1.04576751
82MP0002132_abnormal_respiratory_system1.04321174
83MP0005671_abnormal_response_to1.02114040
84MP0001849_ear_inflammation1.01655941
85MP0009672_abnormal_birth_weight1.00483567
86MP0003315_abnormal_perineum_morphology1.00416688
87MP0001835_abnormal_antigen_presentation1.00303378
88MP0002722_abnormal_immune_system0.98007629
89MP0000733_abnormal_muscle_development0.97974335
90MP0002092_abnormal_eye_morphology0.97585483
91MP0000432_abnormal_head_morphology0.97336363
92MP0002925_abnormal_cardiovascular_devel0.97207650
93MP0000598_abnormal_liver_morphology0.96286052
94MP0000689_abnormal_spleen_morphology0.95403738
95MP0003566_abnormal_cell_adhesion0.95301346
96MP0002166_altered_tumor_susceptibility0.95219184
97MP0009840_abnormal_foam_cell0.95161274
98MP0003300_gastrointestinal_ulcer0.94550301
99MP0001545_abnormal_hematopoietic_system0.93159402
100MP0005397_hematopoietic_system_phenotyp0.93159402
101MP0001661_extended_life_span0.92640493
102MP0001853_heart_inflammation0.91523209
103MP0002697_abnormal_eye_size0.90558387
104MP0002006_tumorigenesis0.90393285
105MP0002210_abnormal_sex_determination0.88309495
106MP0003942_abnormal_urinary_system0.87988276
107MP0005332_abnormal_amino_acid0.87377978
108MP0001286_abnormal_eye_development0.87069796
109MP0003436_decreased_susceptibility_to0.85372188
110MP0002452_abnormal_antigen_presenting0.85219846
111MP0005023_abnormal_wound_healing0.84610107
112MP0000477_abnormal_intestine_morphology0.83815649
113MP0002932_abnormal_joint_morphology0.83229664
114MP0002282_abnormal_trachea_morphology0.83044815
115MP0005187_abnormal_penis_morphology0.82744855
116MP0000716_abnormal_immune_system0.82480032
117MP0002111_abnormal_tail_morphology0.82143315
118MP0002249_abnormal_larynx_morphology0.82103131
119MP0005174_abnormal_tail_pigmentation0.82052054
120MP0002429_abnormal_blood_cell0.81254113
121MP0005220_abnormal_exocrine_pancreas0.81193651
122MP0003755_abnormal_palate_morphology0.80860213
123MP0001324_abnormal_eye_pigmentation0.80112301
124MP0009785_altered_susceptibility_to0.79539852
125MP0003786_premature_aging0.78456647
126MP0005464_abnormal_platelet_physiology0.78225682
127MP0003656_abnormal_erythrocyte_physiolo0.77718850
128MP0000371_diluted_coat_color0.77162954
129MP0008438_abnormal_cutaneous_collagen0.76412541
130MP0002118_abnormal_lipid_homeostasis0.76391172
131MP0005248_abnormal_Harderian_gland0.76287169
132MP0009333_abnormal_splenocyte_physiolog0.76031524
133MP0001145_abnormal_male_reproductive0.75818489
134MP0003943_abnormal_hepatobiliary_system0.75706829
135MP0002405_respiratory_system_inflammati0.75563532
136MP0000639_abnormal_adrenal_gland0.75372493
137MP0002938_white_spotting0.75105431
138MP0002420_abnormal_adaptive_immunity0.74878926
139MP0000685_abnormal_immune_system0.73852006
140MP0003806_abnormal_nucleotide_metabolis0.73081149
141MP0003191_abnormal_cellular_cholesterol0.72867693
142MP0005058_abnormal_lysosome_morphology0.71775327
143MP0005257_abnormal_intraocular_pressure0.71734537
144MP0000858_altered_metastatic_potential0.71724362
145MP0004019_abnormal_vitamin_homeostasis0.70538397
146MP0005379_endocrine/exocrine_gland_phen0.69534280
147MP0005084_abnormal_gallbladder_morpholo0.67833321
148MP0009115_abnormal_fat_cell0.63733874
149MP0004272_abnormal_basement_membrane0.62762922
150MP0002233_abnormal_nose_morphology0.61613012
151MP0010155_abnormal_intestine_physiology0.60989766
152MP0005164_abnormal_response_to0.60857135

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.24798459
2Prolonged partial thromboplastin time (HP:0003645)5.70041515
3Hypobetalipoproteinemia (HP:0003563)5.59599579
4Pancreatic islet-cell hyperplasia (HP:0004510)4.27519715
5Abnormality of the common coagulation pathway (HP:0010990)4.24492388
6Complement deficiency (HP:0004431)4.13261761
7Short 4th metacarpal (HP:0010044)3.91478901
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.91478901
9Glomerulonephritis (HP:0000099)3.85267195
10Abnormal tarsal ossification (HP:0008369)3.74736150
11Joint hemorrhage (HP:0005261)3.74218744
12Small epiphyses (HP:0010585)3.67146365
13Hypolipoproteinemia (HP:0010981)3.64407231
14Acanthocytosis (HP:0001927)3.63782112
15Volvulus (HP:0002580)3.37564703
16Abnormal foot bone ossification (HP:0010675)3.36256678
17Colon cancer (HP:0003003)3.24001955
18Broad alveolar ridges (HP:0000187)3.17960471
19Medulloblastoma (HP:0002885)3.07888781
20Xanthomatosis (HP:0000991)3.07203536
21Hypercholesterolemia (HP:0003124)3.04724194
22Ependymoma (HP:0002888)3.04312743
23Abnormality of the fingertips (HP:0001211)2.93833980
24Abnormality of the 4th metacarpal (HP:0010012)2.91324927
25Abnormality of the nasal septum (HP:0000419)2.90571219
26Abnormality of complement system (HP:0005339)2.89505757
27Vaginal fistula (HP:0004320)2.88692731
28Systemic lupus erythematosus (HP:0002725)2.88068051
29Abnormality of carpal bone ossification (HP:0006257)2.86553676
30Abnormality of the pancreatic islet cells (HP:0006476)2.82671063
31Abnormality of endocrine pancreas physiology (HP:0012093)2.82671063
32Hepatoblastoma (HP:0002884)2.81997744
33Irregular epiphyses (HP:0010582)2.80569605
34Chromsome breakage (HP:0040012)2.76261108
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.74619722
36Epidermoid cyst (HP:0200040)2.73129063
37Flat acetabular roof (HP:0003180)2.72360591
38Increased nuchal translucency (HP:0010880)2.71505561
39Deviation of the thumb (HP:0009603)2.68418050
40Abnormality of the lumbar spine (HP:0100712)2.67776664
41Proximal placement of thumb (HP:0009623)2.66990409
42Anal stenosis (HP:0002025)2.63684287
43Spontaneous abortion (HP:0005268)2.63013120
44Myocardial infarction (HP:0001658)2.61459949
45Intrahepatic cholestasis (HP:0001406)2.58735698
46Selective tooth agenesis (HP:0001592)2.49384058
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49237492
48Hypoglycemic seizures (HP:0002173)2.49161661
49Renal duplication (HP:0000075)2.47216012
50Wide nose (HP:0000445)2.47143925
51Menorrhagia (HP:0000132)2.46364220
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.44765859
53Vascular calcification (HP:0004934)2.40914082
54Enlarged kidneys (HP:0000105)2.38630665
55Epiphyseal dysplasia (HP:0002656)2.38081234
56Rectovaginal fistula (HP:0000143)2.36596382
57Rectal fistula (HP:0100590)2.36596382
58Abnormal number of incisors (HP:0011064)2.35762023
59Astrocytoma (HP:0009592)2.33835993
60Abnormality of the astrocytes (HP:0100707)2.33835993
61Ectopic kidney (HP:0000086)2.33742938
62Hepatocellular carcinoma (HP:0001402)2.32926759
63Subacute progressive viral hepatitis (HP:0006572)2.32554017
64Gastrointestinal carcinoma (HP:0002672)2.30232371
65Malignant gastrointestinal tract tumors (HP:0006749)2.30232371
66Long eyelashes (HP:0000527)2.30007073
67Hypophosphatemic rickets (HP:0004912)2.29373212
68Rhabdomyosarcoma (HP:0002859)2.25206925
69Basal cell carcinoma (HP:0002671)2.25106426
70Supernumerary ribs (HP:0005815)2.24463271
71Hypoglycemic coma (HP:0001325)2.23791361
72Abnormal hand bone ossification (HP:0010660)2.22812565
73Diastasis recti (HP:0001540)2.22102138
74Agnosia (HP:0010524)2.21083681
75Abnormality of the wing of the ilium (HP:0011867)2.16646716
76Hypothermia (HP:0002045)2.16498942
77Facial hemangioma (HP:0000329)2.16058668
78Neoplasm of the oral cavity (HP:0100649)2.14734564
79Intestinal fistula (HP:0100819)2.14482014
80Supernumerary bones of the axial skeleton (HP:0009144)2.13761265
81Fat malabsorption (HP:0002630)2.12687931
82Thrombophlebitis (HP:0004418)2.12552154
83Limited elbow extension (HP:0001377)2.12228564
84Gingival bleeding (HP:0000225)2.12063745
85Neoplasm of striated muscle (HP:0009728)2.11972016
86Reticulocytopenia (HP:0001896)2.11507911
87Delayed closure of the anterior fontanelle (HP:0001476)2.10925191
88Myelodysplasia (HP:0002863)2.10800405
89Hyperacusis (HP:0010780)2.09865213
90Amaurosis fugax (HP:0100576)2.09605989
91Spinal cord lesions (HP:0100561)2.08924822
92Syringomyelia (HP:0003396)2.08924822
93Hemorrhage of the eye (HP:0011885)2.07986355
94Hypoalphalipoproteinemia (HP:0003233)2.07825759
95Cardiovascular calcification (HP:0011915)2.06368828
96Thrombocytosis (HP:0001894)2.06282509
97Pigmentary retinal degeneration (HP:0001146)2.06005373
98Abnormality of the labia minora (HP:0012880)2.05040276
99Biliary tract neoplasm (HP:0100574)2.04556426
100Abnormality of chromosome stability (HP:0003220)2.03716186
101Skull defect (HP:0001362)2.03696948
102Atresia of the external auditory canal (HP:0000413)2.03665423
103Asymmetry of the thorax (HP:0001555)2.03348549
104Aplasia/Hypoplasia of the sternum (HP:0006714)2.02736747
105Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.01070586
106Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00669824
107Broad thumb (HP:0011304)2.00645417
108Cutis marmorata (HP:0000965)1.99520278
109Flared iliac wings (HP:0002869)1.99243992
110Patellar aplasia (HP:0006443)1.97843646
111Abnormal lung lobation (HP:0002101)1.96857976
112Abnormal ossification of hand bones (HP:0005921)1.96245600
113Viral hepatitis (HP:0006562)1.93414849
114Sandal gap (HP:0001852)1.92295510
115Metaphyseal irregularity (HP:0003025)1.91131466
116Glioma (HP:0009733)1.90872623
117Skin tags (HP:0010609)1.90693497
118Midline defect of the nose (HP:0004122)1.90010617
119Nephroblastoma (Wilms tumor) (HP:0002667)1.89945640
120Abnormality of methionine metabolism (HP:0010901)1.89221369
121Meckel diverticulum (HP:0002245)1.88358073
122Aplasia/Hypoplasia of the patella (HP:0006498)1.86704166
123Abnormality of monocarboxylic acid metabolism (HP:0010996)1.86702086
124Gastrointestinal infarctions (HP:0005244)1.86329017
125Trigonocephaly (HP:0000243)1.86204487
126Acute myeloid leukemia (HP:0004808)1.86162111
127Prominent nose (HP:0000448)1.85442321
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.84067885
129Neoplasm of the liver (HP:0002896)1.83368828
130Gonadal dysgenesis (HP:0000133)1.80994539
131Supernumerary spleens (HP:0009799)1.80309165
132Renovascular hypertension (HP:0100817)1.79955735
133Missing ribs (HP:0000921)1.79424770
134Recurrent gram-negative bacterial infections (HP:0005420)1.79314382
135Embryonal neoplasm (HP:0002898)1.78954255
136Embryonal renal neoplasm (HP:0011794)1.77685647
137Abnormality of the alveolar ridges (HP:0006477)1.77447255
138Abnormality of the ileum (HP:0001549)1.77426136
139Increased serum pyruvate (HP:0003542)1.74578093
140Uterine neoplasm (HP:0010784)1.74468025
141Broad palm (HP:0001169)1.74013072
142Deep philtrum (HP:0002002)1.73959270
143Nephritis (HP:0000123)1.73424462
144Conjugated hyperbilirubinemia (HP:0002908)1.73262197
14511 pairs of ribs (HP:0000878)1.73203237
146Papillary thyroid carcinoma (HP:0002895)1.73170337
147Low anterior hairline (HP:0000294)1.72836457
148Overlapping toe (HP:0001845)1.71676301
149Bifid tongue (HP:0010297)1.71600072
150Abnormality of T cell number (HP:0011839)1.71338699
151T lymphocytopenia (HP:0005403)1.71003157
152Cutaneous melanoma (HP:0012056)1.69739123
153Cupped ribs (HP:0000887)1.68896039
154Abnormality of the carotid arteries (HP:0005344)1.68741613
155Short phalanx of the thumb (HP:0009660)1.68655324
156Arterial tortuosity (HP:0005116)1.68456325
157Hyperinsulinemic hypoglycemia (HP:0000825)1.67830342
158Symptomatic seizures (HP:0011145)1.67539060
159Preauricular skin tag (HP:0000384)1.67491969
160Truncal obesity (HP:0001956)1.67460906
161Bladder neoplasm (HP:0009725)1.67183723
162Bladder carcinoma (HP:0002862)1.67183723
163Bicuspid aortic valve (HP:0001647)1.67068589
164Increased density of long bones (HP:0006392)1.66379020
165High pitched voice (HP:0001620)1.66313589
166Uterine leiomyosarcoma (HP:0002891)1.65866592
167Leiomyosarcoma (HP:0100243)1.65866592
168Rectal prolapse (HP:0002035)1.65864949
169Recurrent viral infections (HP:0004429)1.65628652
170Transitional cell carcinoma of the bladder (HP:0006740)1.64435822
171Broad phalanges of the hand (HP:0009768)1.64140067
172Abnormality of the phalanges of the hallux (HP:0010057)1.63954779
173Urethral obstruction (HP:0000796)1.62898196
174Absent frontal sinuses (HP:0002688)1.62009682
175Aplasia/Hypoplasia of the uvula (HP:0010293)1.61888630
176Small intestinal stenosis (HP:0012848)1.61780021
177Duodenal stenosis (HP:0100867)1.61780021
178High anterior hairline (HP:0009890)1.61713909
179Large earlobe (HP:0009748)1.60159954
180Rib fusion (HP:0000902)1.59756402
181Heterotopia (HP:0002282)1.59513161
182Aplastic anemia (HP:0001915)1.58168399
183Abnormality of the diencephalon (HP:0010662)1.58141005
184Intestinal polyp (HP:0005266)1.57571504
185Cafe-au-lait spot (HP:0000957)1.57111154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR44.56761351
2CDC74.31697269
3CDK124.05520186
4MAP3K103.18792252
5EEF2K3.14713787
6NEK22.77200654
7MST42.74671372
8MAP4K12.31056148
9PKN22.24860793
10MKNK12.18224867
11WEE12.12057403
12BRD42.10458614
13SRPK12.08465984
14WNK42.00402683
15TRIM281.99739751
16SCYL21.96786540
17STK101.94556428
18RPS6KB21.93062127
19NLK1.86207170
20ACVR1B1.85330527
21PASK1.84799152
22TTK1.82605158
23STK391.79546909
24BCR1.79214713
25TGFBR11.75757481
26MKNK21.68149547
27CDK41.68071281
28ATR1.67816545
29LATS11.64168285
30SIK31.64155988
31TYK21.60232725
32TSSK61.56622631
33CDK61.52226667
34PIK3CA1.51166108
35CDK71.41498671
36ALK1.39199719
37MAP3K81.36906430
38CHEK11.36705020
39RPS6KA41.33845619
40TXK1.33502988
41PLK11.32704259
42JAK11.28604368
43AURKB1.27945650
44CHEK21.27654516
45AKT31.25337068
46PLK31.21708663
47ATM1.18939495
48BMPR1B1.18106859
49FGR1.16691059
50STK41.16655436
51STK31.16157083
52GRK61.14228456
53MAP3K141.13519934
54WNK11.05087151
55INSRR1.04058586
56JAK31.02416798
57TNIK1.01804971
58PIM11.01646247
59LRRK21.01369086
60DYRK31.01178862
61CDK20.98424066
62MTOR0.96566688
63ERBB40.96056725
64CDK90.95645889
65PTK60.92952400
66NUAK10.92734949
67PAK40.91960849
68MELK0.91618607
69STK38L0.90401217
70TLK10.89108040
71BRSK20.88019450
72EIF2AK20.86109446
73BRSK10.86028341
74FGFR30.83231344
75CSF1R0.82755345
76BUB10.81938849
77ICK0.81901949
78STK240.81546067
79MAP2K30.81279187
80FLT30.81223897
81PDGFRA0.80987808
82BTK0.79509297
83FRK0.79233209
84PBK0.78557108
85TAF10.78474733
86SIK20.76102015
87PRKAA20.75791623
88CLK10.74715326
89PLK40.72415885
90CHUK0.71807352
91MAP3K20.71215825
92CDK10.70548518
93FGFR10.68504708
94NEK10.66879013
95TRIB30.65034952
96CSNK1D0.61878295
97MST1R0.60686577
98EIF2AK30.60546729
99ERBB20.58924723
100ITK0.57855690
101PRKDC0.57012584
102RET0.55199705
103ZAK0.55019288
104MARK30.54586576
105KSR10.54233006
106IRAK10.53740191
107CAMKK20.52966800
108TGFBR20.51794134
109MAPK140.51754568
110IGF1R0.50925500
111WNK30.50355685
112EPHA20.50031293
113CSNK2A20.49056267
114RIPK10.48830165
115CAMK1D0.48543675
116TEC0.47265843
117CSNK1E0.46939820
118IRAK30.46382205
119MAPK110.45659943
120TYRO30.45485102
121CDK80.45128213
122CSNK1G10.44733869
123FER0.44481131
124PDGFRB0.43592730
125SGK30.43345755
126NEK90.43242936
127EIF2AK10.43099399
128ZAP700.42951797
129PAK20.42823722
130CSNK1A1L0.42368544
131NEK60.42196523
132LATS20.41929941
133FGFR20.40845906
134AKT10.38906315
135RPS6KB10.38367982
136YES10.38161544
137ERBB30.37914649
138MAPK10.36633272
139HCK0.34822025
140LCK0.34314128
141AKT20.32891798
142GSK3B0.32796996
143TTN0.31693363
144CSK0.30722771
145TRPM70.30299441

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.61189110
2DNA replication_Homo sapiens_hsa030303.48356308
3Mismatch repair_Homo sapiens_hsa034303.25500178
4Steroid biosynthesis_Homo sapiens_hsa001002.80867227
5Spliceosome_Homo sapiens_hsa030402.75552585
6RNA transport_Homo sapiens_hsa030132.65301059
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63483759
8Cell cycle_Homo sapiens_hsa041102.61300354
9Fat digestion and absorption_Homo sapiens_hsa049752.58081676
10Vitamin digestion and absorption_Homo sapiens_hsa049772.38406703
11One carbon pool by folate_Homo sapiens_hsa006702.24157062
12Base excision repair_Homo sapiens_hsa034102.22639721
13mRNA surveillance pathway_Homo sapiens_hsa030152.20820120
14Staphylococcus aureus infection_Homo sapiens_hsa051502.19582680
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03290364
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01185915
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.97123709
18Fatty acid biosynthesis_Homo sapiens_hsa000611.97085547
19Homologous recombination_Homo sapiens_hsa034401.91752658
20Non-homologous end-joining_Homo sapiens_hsa034501.87468780
21Nucleotide excision repair_Homo sapiens_hsa034201.86446656
22Fatty acid degradation_Homo sapiens_hsa000711.76041504
23Fanconi anemia pathway_Homo sapiens_hsa034601.74622735
24RNA degradation_Homo sapiens_hsa030181.73169191
25Fatty acid metabolism_Homo sapiens_hsa012121.73156434
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69843045
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67968780
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67311085
29Arginine biosynthesis_Homo sapiens_hsa002201.61112708
30MicroRNAs in cancer_Homo sapiens_hsa052061.60257366
31Propanoate metabolism_Homo sapiens_hsa006401.59594594
32Ribosome_Homo sapiens_hsa030101.53499988
33Systemic lupus erythematosus_Homo sapiens_hsa053221.49392600
34Primary immunodeficiency_Homo sapiens_hsa053401.47783171
35Herpes simplex infection_Homo sapiens_hsa051681.44364650
36Antigen processing and presentation_Homo sapiens_hsa046121.44240675
37Other glycan degradation_Homo sapiens_hsa005111.43143884
38Starch and sucrose metabolism_Homo sapiens_hsa005001.42633678
39Viral carcinogenesis_Homo sapiens_hsa052031.41098126
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40426349
41p53 signaling pathway_Homo sapiens_hsa041151.37816799
42N-Glycan biosynthesis_Homo sapiens_hsa005101.36691943
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36370872
44PPAR signaling pathway_Homo sapiens_hsa033201.36161219
45B cell receptor signaling pathway_Homo sapiens_hsa046621.35981482
46Chronic myeloid leukemia_Homo sapiens_hsa052201.32297070
47HTLV-I infection_Homo sapiens_hsa051661.32166205
48Basal cell carcinoma_Homo sapiens_hsa052171.28961514
49Small cell lung cancer_Homo sapiens_hsa052221.25327541
50Colorectal cancer_Homo sapiens_hsa052101.24630115
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23258588
52Adherens junction_Homo sapiens_hsa045201.21823087
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.20470338
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19159759
55Basal transcription factors_Homo sapiens_hsa030221.16026157
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.15896140
57Epstein-Barr virus infection_Homo sapiens_hsa051691.15876009
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.15863226
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14590232
60Vitamin B6 metabolism_Homo sapiens_hsa007501.13037547
61Thyroid cancer_Homo sapiens_hsa052161.12167871
62TGF-beta signaling pathway_Homo sapiens_hsa043501.07135507
63Hippo signaling pathway_Homo sapiens_hsa043901.06960903
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05585973
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04531763
66Oocyte meiosis_Homo sapiens_hsa041141.02222750
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01222006
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00964490
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00207753
70Lysine degradation_Homo sapiens_hsa003100.99487514
71RNA polymerase_Homo sapiens_hsa030200.98777314
72Pyrimidine metabolism_Homo sapiens_hsa002400.97538261
73mTOR signaling pathway_Homo sapiens_hsa041500.97006628
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96075896
75Hepatitis B_Homo sapiens_hsa051610.95534915
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95389915
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95263277
78Histidine metabolism_Homo sapiens_hsa003400.94926159
79Pancreatic cancer_Homo sapiens_hsa052120.94182029
80Retinol metabolism_Homo sapiens_hsa008300.93796259
81ABC transporters_Homo sapiens_hsa020100.93630352
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93117791
83Notch signaling pathway_Homo sapiens_hsa043300.91930655
84T cell receptor signaling pathway_Homo sapiens_hsa046600.90467421
85Renin-angiotensin system_Homo sapiens_hsa046140.88912428
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.88854986
87Measles_Homo sapiens_hsa051620.88190331
88Proteoglycans in cancer_Homo sapiens_hsa052050.88016850
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86952446
90Prostate cancer_Homo sapiens_hsa052150.86542122
91Endometrial cancer_Homo sapiens_hsa052130.86313657
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84401057
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83776680
94Viral myocarditis_Homo sapiens_hsa054160.82976477
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81062804
96Acute myeloid leukemia_Homo sapiens_hsa052210.80199939
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80093933
98Pathways in cancer_Homo sapiens_hsa052000.79592086
99Leishmaniasis_Homo sapiens_hsa051400.79541535
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.78241322
101Influenza A_Homo sapiens_hsa051640.77877785
102* Non-small cell lung cancer_Homo sapiens_hsa052230.77438375
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75910908
104Wnt signaling pathway_Homo sapiens_hsa043100.75819541
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.75751777
106Hedgehog signaling pathway_Homo sapiens_hsa043400.75302994
107Toxoplasmosis_Homo sapiens_hsa051450.75302423
108Proteasome_Homo sapiens_hsa030500.74448950
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.73651039
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.72852389
111Peroxisome_Homo sapiens_hsa041460.72639374
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72202273
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72193391
114Shigellosis_Homo sapiens_hsa051310.71371335
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70241373
116Pertussis_Homo sapiens_hsa051330.69686070
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69525231
118Osteoclast differentiation_Homo sapiens_hsa043800.69410377
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.69166675
120Hematopoietic cell lineage_Homo sapiens_hsa046400.68895080
121Galactose metabolism_Homo sapiens_hsa000520.68211041
122Apoptosis_Homo sapiens_hsa042100.67582686
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66994969
124Protein export_Homo sapiens_hsa030600.66306963
125Alcoholism_Homo sapiens_hsa050340.65778817
126Legionellosis_Homo sapiens_hsa051340.65740028
127Glycerolipid metabolism_Homo sapiens_hsa005610.64572796
128Circadian rhythm_Homo sapiens_hsa047100.64547518
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.62087724
130Chemical carcinogenesis_Homo sapiens_hsa052040.60730211
131Platelet activation_Homo sapiens_hsa046110.58754662
132Selenocompound metabolism_Homo sapiens_hsa004500.56451998
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.56167496
134FoxO signaling pathway_Homo sapiens_hsa040680.55146285
135TNF signaling pathway_Homo sapiens_hsa046680.55141191
136HIF-1 signaling pathway_Homo sapiens_hsa040660.54129668
137Glioma_Homo sapiens_hsa052140.53327130
138Focal adhesion_Homo sapiens_hsa045100.52858797
139Insulin resistance_Homo sapiens_hsa049310.51793718
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.49325829
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48680644
142Bladder cancer_Homo sapiens_hsa052190.47816610
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46514709
144Pyruvate metabolism_Homo sapiens_hsa006200.46263219
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46176541
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46058010
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45819559
148Fructose and mannose metabolism_Homo sapiens_hsa000510.45705388
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.45382263
150Biosynthesis of amino acids_Homo sapiens_hsa012300.44862020
151Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44621801
152Sphingolipid metabolism_Homo sapiens_hsa006000.44491633
153Prolactin signaling pathway_Homo sapiens_hsa049170.43663230
154Tight junction_Homo sapiens_hsa045300.43193134
155Arginine and proline metabolism_Homo sapiens_hsa003300.43141172
156Fatty acid elongation_Homo sapiens_hsa000620.42771125
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42334175
158Melanoma_Homo sapiens_hsa052180.42148983
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40875104
160Dorso-ventral axis formation_Homo sapiens_hsa043200.40461880
161Thyroid hormone synthesis_Homo sapiens_hsa049180.40417820
162Renal cell carcinoma_Homo sapiens_hsa052110.39541077
163Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39509262
164VEGF signaling pathway_Homo sapiens_hsa043700.38858746
165Rap1 signaling pathway_Homo sapiens_hsa040150.38062643

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