EML5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.80227305
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.50120185
3behavioral response to nicotine (GO:0035095)5.32756328
4enteric nervous system development (GO:0048484)4.98594541
5synaptic vesicle exocytosis (GO:0016079)4.80804462
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74980704
7regulation of synaptic vesicle exocytosis (GO:2000300)4.61536727
8synaptic vesicle maturation (GO:0016188)4.57026009
9sympathetic nervous system development (GO:0048485)4.52577773
10regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.43745498
11locomotory exploration behavior (GO:0035641)4.37308758
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.34818610
13vocalization behavior (GO:0071625)4.27555703
14protein localization to synapse (GO:0035418)4.23334598
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.19125015
16regulation of synaptic vesicle transport (GO:1902803)4.13246847
17neuron cell-cell adhesion (GO:0007158)4.01580466
18glutamate secretion (GO:0014047)3.97114609
19regulation of glutamate receptor signaling pathway (GO:1900449)3.91458110
20neurotransmitter secretion (GO:0007269)3.90760605
21synaptic transmission, glutamatergic (GO:0035249)3.90180353
22neuronal action potential propagation (GO:0019227)3.86564132
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.82767359
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81501818
25neurotransmitter-gated ion channel clustering (GO:0072578)3.79292023
26cerebellar Purkinje cell differentiation (GO:0021702)3.74881469
27neuron-neuron synaptic transmission (GO:0007270)3.72809814
28response to pheromone (GO:0019236)3.71703112
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70913099
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.70544624
31glutamate receptor signaling pathway (GO:0007215)3.69628864
32innervation (GO:0060384)3.66671586
33cellular potassium ion homeostasis (GO:0030007)3.60188860
34presynaptic membrane assembly (GO:0097105)3.59880738
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.57550392
36positive regulation of synapse maturation (GO:0090129)3.53545775
37synaptic vesicle endocytosis (GO:0048488)3.53443387
38positive regulation of membrane potential (GO:0045838)3.45998269
39regulation of secondary heart field cardioblast proliferation (GO:0003266)3.45705264
40regulation of cardioblast proliferation (GO:0003264)3.45705264
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45420143
42long-term memory (GO:0007616)3.44311821
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42586216
44regulation of neuronal synaptic plasticity (GO:0048168)3.41302906
45postsynaptic membrane organization (GO:0001941)3.38924208
46regulation of vesicle fusion (GO:0031338)3.35381958
47regulation of postsynaptic membrane potential (GO:0060078)3.33701060
48layer formation in cerebral cortex (GO:0021819)3.33349911
49membrane hyperpolarization (GO:0060081)3.33316052
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33144963
51regulation of neurotransmitter secretion (GO:0046928)3.32981779
52membrane depolarization during action potential (GO:0086010)3.31959713
53dendritic spine morphogenesis (GO:0060997)3.29253020
54neurotransmitter transport (GO:0006836)3.28503997
55regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26376621
56presynaptic membrane organization (GO:0097090)3.25681974
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.22008661
58cell differentiation in hindbrain (GO:0021533)3.21517702
59cerebellar granule cell differentiation (GO:0021707)3.21378216
60exploration behavior (GO:0035640)3.21375387
61retinal rod cell development (GO:0046548)3.21252727
62cell communication by electrical coupling (GO:0010644)3.17952528
63sodium ion export (GO:0071436)3.17870607
64regulation of calcium ion-dependent exocytosis (GO:0017158)3.16884842
65detection of calcium ion (GO:0005513)3.15152640
66regulation of respiratory gaseous exchange (GO:0043576)3.10024384
67long-term synaptic potentiation (GO:0060291)3.09804469
68dopaminergic neuron differentiation (GO:0071542)3.09589598
69regulation of respiratory system process (GO:0044065)3.09346031
70neuron recognition (GO:0008038)3.07979103
71regulation of neurotransmitter transport (GO:0051588)3.07560937
72mating behavior (GO:0007617)3.04732229
73transmission of nerve impulse (GO:0019226)3.04499148
74photoreceptor cell development (GO:0042461)3.04317804
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04025386
76axonal fasciculation (GO:0007413)3.00758909
77synapse assembly (GO:0007416)2.99716050
78striatum development (GO:0021756)2.99651888
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99576590
80chemosensory behavior (GO:0007635)2.99372422
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99085750
82positive regulation of neurotransmitter transport (GO:0051590)2.98568259
83regulation of synaptic transmission, glutamatergic (GO:0051966)2.98555100
84retinal cone cell development (GO:0046549)2.97670135
85behavioral response to ethanol (GO:0048149)2.96261783
86auditory behavior (GO:0031223)2.96259412
87eye photoreceptor cell development (GO:0042462)2.96079589
88regulation of synapse structural plasticity (GO:0051823)2.96076400
89activation of protein kinase A activity (GO:0034199)2.93509403
90negative regulation of dendrite morphogenesis (GO:0050774)2.92982258
91cell migration in hindbrain (GO:0021535)2.92649149
92membrane depolarization (GO:0051899)2.92385968
93calcium ion import (GO:0070509)2.91494803
94gamma-aminobutyric acid transport (GO:0015812)2.90422404
95insulin secretion (GO:0030073)2.90176999
96positive regulation of neurotransmitter secretion (GO:0001956)2.89328374
97hindbrain development (GO:0030902)2.89226950
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88222160
99prepulse inhibition (GO:0060134)2.88036241
100dendrite morphogenesis (GO:0048813)2.86844785
101intraciliary transport (GO:0042073)2.86426062
102mechanosensory behavior (GO:0007638)2.86204424
103negative regulation of dendrite development (GO:2000171)2.86055321
104protein localization to cilium (GO:0061512)2.85715066
105regulation of ARF protein signal transduction (GO:0032012)2.83621781
106regulation of synapse maturation (GO:0090128)2.82003259
107regulation of neurotransmitter levels (GO:0001505)2.81805480
108regulation of synaptic plasticity (GO:0048167)2.81415692
109potassium ion homeostasis (GO:0055075)2.80432993
110response to histamine (GO:0034776)2.79908901
111positive regulation of exocytosis (GO:0045921)2.79615275
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77076832
113piRNA metabolic process (GO:0034587)2.76706240
114startle response (GO:0001964)2.74482519
115positive regulation of transcription regulatory region DNA binding (GO:2000679)2.73675427
116epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67963270
117RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67709300
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67709300
119righting reflex (GO:0060013)2.65953860
120spinal cord motor neuron differentiation (GO:0021522)2.65500968
121regulation of glucokinase activity (GO:0033131)2.59711637
122regulation of hexokinase activity (GO:1903299)2.59711637
123inositol phosphate catabolic process (GO:0071545)2.59573494
124tongue development (GO:0043586)2.58292276
125epithelial cilium movement (GO:0003351)2.58182298
126positive regulation of histone H3-K4 methylation (GO:0051571)2.49259096
127suckling behavior (GO:0001967)2.49196040
128neuromuscular synaptic transmission (GO:0007274)2.48985948
129regulation of meiosis I (GO:0060631)2.46992836
130central nervous system neuron axonogenesis (GO:0021955)2.41174072
131neuron fate determination (GO:0048664)2.40420743
132cilium movement (GO:0003341)2.38126264
133glycerophospholipid catabolic process (GO:0046475)2.38022784
134inositol phosphate dephosphorylation (GO:0046855)2.34980934
135phosphorylated carbohydrate dephosphorylation (GO:0046838)2.34980934
136nonmotile primary cilium assembly (GO:0035058)2.33969411
137cochlea development (GO:0090102)2.33131352
138ganglion development (GO:0061548)2.32713098
139retinal ganglion cell axon guidance (GO:0031290)2.32116342
140retina layer formation (GO:0010842)2.32094593
141somite rostral/caudal axis specification (GO:0032525)2.31397474
142reflex (GO:0060004)2.31229315
143regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.30829896
144centriole replication (GO:0007099)2.29795445
145cilium assembly (GO:0042384)2.28316054
146cilium organization (GO:0044782)2.28181781
147regulation of heart morphogenesis (GO:2000826)2.26113335
148positive regulation of gastrulation (GO:2000543)2.24772938
149serotonin metabolic process (GO:0042428)2.24249251
150positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.24133531
151positive regulation of cell cycle G2/M phase transition (GO:1902751)2.24133531
152regulation of feeding behavior (GO:0060259)2.23954838
153regulation of acrosome reaction (GO:0060046)2.23461511
154peripheral nervous system neuron development (GO:0048935)2.21865270
155polyol catabolic process (GO:0046174)2.21064715
156synapsis (GO:0007129)2.19446584
157negative regulation of astrocyte differentiation (GO:0048712)2.19102019
158synaptic transmission, cholinergic (GO:0007271)2.18637802
159regulation of centriole replication (GO:0046599)2.18467523
160cartilage morphogenesis (GO:0060536)2.17910770
161response to auditory stimulus (GO:0010996)2.16496538
162protein K6-linked ubiquitination (GO:0085020)2.16235640
163catechol-containing compound biosynthetic process (GO:0009713)2.16184716
164catecholamine biosynthetic process (GO:0042423)2.16184716
165cranial nerve development (GO:0021545)2.16120308
166water-soluble vitamin biosynthetic process (GO:0042364)2.16058785
167pyrimidine nucleobase catabolic process (GO:0006208)2.15603653
168negative regulation of DNA-dependent DNA replication (GO:2000104)2.13300717
169positive regulation of meiosis (GO:0045836)2.13007640
170nucleobase catabolic process (GO:0046113)2.11594042
171nephron tubule morphogenesis (GO:0072078)2.11115310
172nephron epithelium morphogenesis (GO:0072088)2.11115310
173maternal behavior (GO:0042711)2.11024918
174fear response (GO:0042596)2.10846509
175central nervous system projection neuron axonogenesis (GO:0021952)2.09570849
176endocrine pancreas development (GO:0031018)2.09451889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22261499
2GBX2_23144817_ChIP-Seq_PC3_Human3.94034414
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79252449
4REST_21632747_ChIP-Seq_MESCs_Mouse2.79086313
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75999598
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67982686
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59542523
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.56300577
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.42092246
10DROSHA_22980978_ChIP-Seq_HELA_Human2.38940120
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36555033
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36511936
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32969762
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.32944139
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29792808
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29792808
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26818055
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.24294437
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21003248
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20936232
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20247543
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.11408684
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08616635
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.06417047
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02353567
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01842615
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.00469873
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99149872
29EWS_26573619_Chip-Seq_HEK293_Human1.97069047
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.96447620
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84518843
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84483263
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82268163
34SMAD4_21799915_ChIP-Seq_A2780_Human1.80096163
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75467274
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72570208
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67674281
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66667675
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65338970
40IGF1R_20145208_ChIP-Seq_DFB_Human1.63904840
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62782032
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61424777
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59523519
44TAF15_26573619_Chip-Seq_HEK293_Human1.54752165
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54490042
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53585096
47STAT3_23295773_ChIP-Seq_U87_Human1.51584032
48* P300_19829295_ChIP-Seq_ESCs_Human1.50588775
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.49456563
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.46812674
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46316455
52AR_21572438_ChIP-Seq_LNCaP_Human1.42267504
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.39166600
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38983906
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.37114506
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.35967093
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35558987
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35386079
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.34893105
60AR_19668381_ChIP-Seq_PC3_Human1.34435343
61* TCF4_23295773_ChIP-Seq_U87_Human1.31252956
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30799489
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30585309
64CBP_20019798_ChIP-Seq_JUKART_Human1.30585309
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29491886
66RNF2_27304074_Chip-Seq_NSC_Mouse1.29419960
67ZNF274_21170338_ChIP-Seq_K562_Hela1.28374998
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26631864
69AR_25329375_ChIP-Seq_VCAP_Human1.25472486
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24665399
71* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24338715
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23896434
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23842569
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22024462
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21228039
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21200807
77* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20817620
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20327613
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20014592
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19275210
81FUS_26573619_Chip-Seq_HEK293_Human1.17370145
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17076091
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.16163378
84* FLI1_21867929_ChIP-Seq_TH2_Mouse1.15865816
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15513537
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14446903
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14369804
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.13343577
89RUNX2_22187159_ChIP-Seq_PCA_Human1.12875796
90* RING1B_27294783_Chip-Seq_NPCs_Mouse1.12611018
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12439835
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.12048450
93* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10885592
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.10392355
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.09959762
96* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09547836
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08932003
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08516284
99BCAT_22108803_ChIP-Seq_LS180_Human1.07507233
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06783976
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.06714626
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06486502
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05374183
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05078590
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04828310
106MYC_18940864_ChIP-ChIP_HL60_Human1.04631025
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.04554622
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04149368
109TCF4_22108803_ChIP-Seq_LS180_Human1.03681496
110AHR_22903824_ChIP-Seq_MCF-7_Human1.03156423
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02766093
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02702766
113GABP_17652178_ChIP-ChIP_JURKAT_Human1.02405677
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02081852
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01872104
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01872104
117* SMAD3_21741376_ChIP-Seq_ESCs_Human1.01561480
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01288842
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.01238081
120* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00559078
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00234540
122TP53_22573176_ChIP-Seq_HFKS_Human0.99566108
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.99225590
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98288908
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96891175
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96573363
127VDR_22108803_ChIP-Seq_LS180_Human0.93803649
128E2F1_18555785_Chip-Seq_ESCs_Mouse0.92193684
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.91986035
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91391252
131ER_23166858_ChIP-Seq_MCF-7_Human0.91305124
132KDM2B_26808549_Chip-Seq_K562_Human0.90163335
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90069290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.39758663
2MP0003880_abnormal_central_pattern3.49042202
3MP0003635_abnormal_synaptic_transmissio3.25647900
4MP0004270_analgesia3.03647605
5MP0005551_abnormal_eye_electrophysiolog2.77342706
6MP0009745_abnormal_behavioral_response2.71122483
7MP0003787_abnormal_imprinting2.64428121
8MP0009046_muscle_twitch2.63415101
9MP0002063_abnormal_learning/memory/cond2.63256785
10MP0006072_abnormal_retinal_apoptosis2.61945624
11MP0002822_catalepsy2.57883654
12MP0002638_abnormal_pupillary_reflex2.56379171
13MP0002064_seizures2.52516664
14MP0005423_abnormal_somatic_nervous2.42762736
15MP0002572_abnormal_emotion/affect_behav2.31866419
16MP0002272_abnormal_nervous_system2.26408005
17MP0002909_abnormal_adrenal_gland2.21384997
18MP0001486_abnormal_startle_reflex2.17626749
19MP0002734_abnormal_mechanical_nocicepti2.13622814
20MP0001984_abnormal_olfaction2.10447913
21MP0003122_maternal_imprinting2.08324076
22MP0010386_abnormal_urinary_bladder2.06573341
23MP0005646_abnormal_pituitary_gland2.05534011
24MP0005645_abnormal_hypothalamus_physiol2.02447078
25MP0009780_abnormal_chondrocyte_physiolo2.02142579
26MP0001502_abnormal_circadian_rhythm2.00674241
27MP0001968_abnormal_touch/_nociception1.96775625
28MP0006292_abnormal_olfactory_placode1.90179546
29MP0005253_abnormal_eye_physiology1.88408983
30MP0002067_abnormal_sensory_capabilities1.87993027
31MP0001501_abnormal_sleep_pattern1.75975544
32MP0002184_abnormal_innervation1.75678136
33MP0002557_abnormal_social/conspecific_i1.74824588
34MP0000778_abnormal_nervous_system1.72463070
35MP0001529_abnormal_vocalization1.64825504
36MP0003283_abnormal_digestive_organ1.63770341
37MP0008569_lethality_at_weaning1.62633658
38MP0000569_abnormal_digit_pigmentation1.59372852
39MP0004043_abnormal_pH_regulation1.57625428
40MP0005386_behavior/neurological_phenoty1.57069820
41MP0004924_abnormal_behavior1.57069820
42MP0001440_abnormal_grooming_behavior1.54787955
43MP0002735_abnormal_chemical_nociception1.49914530
44MP0002882_abnormal_neuron_morphology1.48482315
45MP0001188_hyperpigmentation1.47368419
46MP0002733_abnormal_thermal_nociception1.46838932
47MP0004885_abnormal_endolymph1.45082016
48MP0006276_abnormal_autonomic_nervous1.44848466
49MP0003567_abnormal_fetal_cardiomyocyte1.44039368
50MP0000955_abnormal_spinal_cord1.43707048
51MP0001970_abnormal_pain_threshold1.42153191
52MP0000631_abnormal_neuroendocrine_gland1.41823037
53MP0002653_abnormal_ependyma_morphology1.40960824
54MP0008058_abnormal_DNA_repair1.39585747
55MP0004811_abnormal_neuron_physiology1.39169366
56MP0003195_calcinosis1.38432604
57MP0005394_taste/olfaction_phenotype1.35625808
58MP0005499_abnormal_olfactory_system1.35625808
59MP0002229_neurodegeneration1.35454758
60MP0008057_abnormal_DNA_replication1.34836041
61MP0003183_abnormal_peptide_metabolism1.34687471
62MP0000013_abnormal_adipose_tissue1.34141353
63MP0003879_abnormal_hair_cell1.33499883
64MP0000538_abnormal_urinary_bladder1.29404596
65MP0002102_abnormal_ear_morphology1.27010374
66MP0000427_abnormal_hair_cycle1.26363998
67MP0002160_abnormal_reproductive_system1.24374154
68MP0002736_abnormal_nociception_after1.23081557
69MP0003121_genomic_imprinting1.22644519
70MP0008961_abnormal_basal_metabolism1.21633855
71MP0002066_abnormal_motor_capabilities/c1.20485858
72MP0003868_abnormal_feces_composition1.19707576
73MP0001270_distended_abdomen1.19001788
74MP0003136_yellow_coat_color1.18992910
75MP0003890_abnormal_embryonic-extraembry1.18430454
76MP0003937_abnormal_limbs/digits/tail_de1.18217014
77MP0002234_abnormal_pharynx_morphology1.17212596
78MP0002090_abnormal_vision1.15013094
79MP0003633_abnormal_nervous_system1.12600917
80MP0002152_abnormal_brain_morphology1.11751258
81MP0003718_maternal_effect1.10519262
82MP0002752_abnormal_somatic_nervous1.09989544
83MP0005084_abnormal_gallbladder_morpholo1.09232615
84MP0005195_abnormal_posterior_eye1.08938084
85MP0004742_abnormal_vestibular_system1.08483130
86MP0004142_abnormal_muscle_tone1.07922419
87MP0004145_abnormal_muscle_electrophysio1.07251555
88MP0002009_preneoplasia1.06813881
89MP0003119_abnormal_digestive_system1.06383526
90MP0008872_abnormal_physiological_respon1.02283127
91MP0002069_abnormal_eating/drinking_beha0.99164046
92MP0001944_abnormal_pancreas_morphology0.98459126
93MP0002938_white_spotting0.97462800
94MP0000372_irregular_coat_pigmentation0.96768837
95MP0003123_paternal_imprinting0.96344817
96MP0001293_anophthalmia0.96243911
97MP0002928_abnormal_bile_duct0.95256304
98MP0002163_abnormal_gland_morphology0.95234870
99MP0002751_abnormal_autonomic_nervous0.94644539
100MP0005220_abnormal_exocrine_pancreas0.93728568
101MP0004233_abnormal_muscle_weight0.92751964
102MP0002837_dystrophic_cardiac_calcinosis0.92390737
103MP0002693_abnormal_pancreas_physiology0.91525874
104MP0008789_abnormal_olfactory_epithelium0.90854846
105MP0003631_nervous_system_phenotype0.89860047
106MP0004085_abnormal_heartbeat0.89846664
107MP0001929_abnormal_gametogenesis0.88770837
108MP0002210_abnormal_sex_determination0.87372079
109MP0005379_endocrine/exocrine_gland_phen0.85692666
110MP0008877_abnormal_DNA_methylation0.85112808
111MP0001664_abnormal_digestion0.82939599
112MP0005391_vision/eye_phenotype0.81842641
113MP0004133_heterotaxia0.81771452
114MP0001963_abnormal_hearing_physiology0.81473042
115MP0003698_abnormal_male_reproductive0.81271892
116MP0005389_reproductive_system_phenotype0.80637907
117MP0000647_abnormal_sebaceous_gland0.79763259
118MP0001324_abnormal_eye_pigmentation0.79322826
119MP0005187_abnormal_penis_morphology0.79091379
120MP0000653_abnormal_sex_gland0.78133456
121MP0000003_abnormal_adipose_tissue0.76802831
122MP0001986_abnormal_taste_sensitivity0.76695510
123MP0001905_abnormal_dopamine_level0.75313005
124MP0001485_abnormal_pinna_reflex0.73843537
125MP0005535_abnormal_body_temperature0.73630604
126MP0003634_abnormal_glial_cell0.72825004
127MP0003329_amyloid_beta_deposits0.71990288
128MP0003861_abnormal_nervous_system0.69797251
129MP0003632_abnormal_nervous_system0.66996505
130MP0001299_abnormal_eye_distance/0.66642373
131MP0005248_abnormal_Harderian_gland0.66281525

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.66037990
2Congenital stationary night blindness (HP:0007642)4.44447305
3Central scotoma (HP:0000603)4.35062189
4Epileptic encephalopathy (HP:0200134)4.32745205
5Visual hallucinations (HP:0002367)4.23408748
6Focal seizures (HP:0007359)4.07072059
7Febrile seizures (HP:0002373)3.93611337
8Progressive cerebellar ataxia (HP:0002073)3.93122015
9Hypothermia (HP:0002045)3.86925004
10Myokymia (HP:0002411)3.85580980
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.66928912
12Abnormality of macular pigmentation (HP:0008002)3.58983711
13Abnormal rod and cone electroretinograms (HP:0008323)3.48111526
14Atonic seizures (HP:0010819)3.38701850
15Absence seizures (HP:0002121)3.35683392
16Intestinal atresia (HP:0011100)3.26768311
17Bony spicule pigmentary retinopathy (HP:0007737)3.24816646
18Hyperventilation (HP:0002883)3.06813223
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.06605968
20Action tremor (HP:0002345)3.06270395
21Scotoma (HP:0000575)3.03983571
22Dialeptic seizures (HP:0011146)3.00974810
23Decreased central vision (HP:0007663)3.00905221
24Agitation (HP:0000713)2.97127979
25Esophageal atresia (HP:0002032)2.96722437
26Gaze-evoked nystagmus (HP:0000640)2.90688553
27Chronic hepatic failure (HP:0100626)2.90140555
28Broad-based gait (HP:0002136)2.88479397
29Depression (HP:0000716)2.83673170
30Epileptiform EEG discharges (HP:0011182)2.81193329
31Impaired smooth pursuit (HP:0007772)2.77814950
32Truncal ataxia (HP:0002078)2.77575439
33Generalized tonic-clonic seizures (HP:0002069)2.77112489
34Severe visual impairment (HP:0001141)2.76886334
35Gastrointestinal atresia (HP:0002589)2.75145254
36EEG with generalized epileptiform discharges (HP:0011198)2.75021758
37Supernumerary spleens (HP:0009799)2.74620949
38Dysdiadochokinesis (HP:0002075)2.73035222
39Nephronophthisis (HP:0000090)2.70059835
40Pancreatic cysts (HP:0001737)2.69873940
41Abnormality of the labia minora (HP:0012880)2.68521130
42Genetic anticipation (HP:0003743)2.63807705
43Protruding tongue (HP:0010808)2.56450811
44Gait imbalance (HP:0002141)2.53335534
45Hypsarrhythmia (HP:0002521)2.52034156
46Macroorchidism (HP:0000053)2.51152171
47Neuroendocrine neoplasm (HP:0100634)2.50314466
48Poor eye contact (HP:0000817)2.49330716
49Excessive salivation (HP:0003781)2.49173957
50Drooling (HP:0002307)2.49173957
51Abnormality of the phalanges of the 2nd finger (HP:0009541)2.46253244
52Pendular nystagmus (HP:0012043)2.46233171
53Amblyopia (HP:0000646)2.46216743
54Type II diabetes mellitus (HP:0005978)2.44247188
55Congenital primary aphakia (HP:0007707)2.43507794
56Abolished electroretinogram (ERG) (HP:0000550)2.42988439
57Abnormality of ocular smooth pursuit (HP:0000617)2.40984257
58Anxiety (HP:0000739)2.40529983
59Menstrual irregularities (HP:0000858)2.37789404
60Scanning speech (HP:0002168)2.33759095
61Attenuation of retinal blood vessels (HP:0007843)2.30533210
62Impaired social interactions (HP:0000735)2.30377737
63Abnormal social behavior (HP:0012433)2.30377737
64Medial flaring of the eyebrow (HP:0010747)2.29935161
65Abnormality of calcium-phosphate metabolism (HP:0100530)2.27594811
66Type II lissencephaly (HP:0007260)2.26936080
67Decreased circulating renin level (HP:0003351)2.25542432
68Hemiparesis (HP:0001269)2.25217981
69Abnormality of the renal medulla (HP:0100957)2.22698337
70Oligodactyly (hands) (HP:0001180)2.21894282
71Dyschromatopsia (HP:0007641)2.18355658
72Oligodactyly (HP:0012165)2.17583751
73Absent speech (HP:0001344)2.16925899
74Nephrogenic diabetes insipidus (HP:0009806)2.16061822
75Thyroid carcinoma (HP:0002890)2.15630200
76Volvulus (HP:0002580)2.14484646
77Supranuclear gaze palsy (HP:0000605)2.12282511
78Hyperthyroidism (HP:0000836)2.11637507
79Pancreatic fibrosis (HP:0100732)2.10198179
80Renal cortical cysts (HP:0000803)2.10015920
81Abnormality of the renal cortex (HP:0011035)2.08799794
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.07081611
83Dysmetria (HP:0001310)2.06826932
84Abnormal pancreas size (HP:0012094)2.06460557
85Bicornuate uterus (HP:0000813)2.04721283
86Exotropia (HP:0000577)2.04246004
87Hypoglycemic coma (HP:0001325)2.02575082
88Optic nerve hypoplasia (HP:0000609)2.01643304
89Septo-optic dysplasia (HP:0100842)1.99610774
90Short tibia (HP:0005736)1.99362448
91Retinal dysplasia (HP:0007973)1.98822422
92Occipital encephalocele (HP:0002085)1.98557517
93Ankle clonus (HP:0011448)1.98120678
94Urinary bladder sphincter dysfunction (HP:0002839)1.96146638
95Postural instability (HP:0002172)1.94070148
96Posterior subcapsular cataract (HP:0007787)1.89659036
97True hermaphroditism (HP:0010459)1.89135394
98Chorioretinal atrophy (HP:0000533)1.89131510
99Blue irides (HP:0000635)1.89030396
100Impaired vibration sensation in the lower limbs (HP:0002166)1.88962313
101Hypoventilation (HP:0002791)1.88391802
102Photophobia (HP:0000613)1.88107090
103Constricted visual fields (HP:0001133)1.87007706
104Dysmetric saccades (HP:0000641)1.84785832
105Specific learning disability (HP:0001328)1.84558245
106Molar tooth sign on MRI (HP:0002419)1.83993811
107Abnormality of midbrain morphology (HP:0002418)1.83993811
108Poor coordination (HP:0002370)1.83857661
109Prolonged QT interval (HP:0001657)1.82213238
110Pheochromocytoma (HP:0002666)1.82212463
111Chromsome breakage (HP:0040012)1.81048993
112Abnormality of the lower motor neuron (HP:0002366)1.80733446
113Limb dystonia (HP:0002451)1.80703449
114Labial hypoplasia (HP:0000066)1.80467968
115Retinitis pigmentosa (HP:0000510)1.79818399
116Postural tremor (HP:0002174)1.78755773
117Bradykinesia (HP:0002067)1.78646538
118Spastic gait (HP:0002064)1.78155331
119Genital tract atresia (HP:0001827)1.78094758
120Vaginal atresia (HP:0000148)1.77566019
121Cone-rod dystrophy (HP:0000548)1.77362980
122Keratoconus (HP:0000563)1.77272404
123Increased corneal curvature (HP:0100692)1.77272404
124Colon cancer (HP:0003003)1.76540239
125Neoplasm of the heart (HP:0100544)1.75285227
126Abnormality of the fovea (HP:0000493)1.74460300
127Large for gestational age (HP:0001520)1.72894397
128Abnormal eating behavior (HP:0100738)1.72110304
129Aplasia/Hypoplasia of the fovea (HP:0008060)1.71994739
130Hypoplasia of the fovea (HP:0007750)1.71994739
131Stereotypic behavior (HP:0000733)1.71925718
132Abnormality of the parathyroid morphology (HP:0011766)1.71196173
133Pachygyria (HP:0001302)1.70336699
134Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69004552
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68547908
136Postaxial hand polydactyly (HP:0001162)1.68342884
137Partial agenesis of the corpus callosum (HP:0001338)1.67484129
138Hypoplastic nipples (HP:0002557)1.67352454
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.67000832
140Ectopic kidney (HP:0000086)1.66651358
141Renal dysplasia (HP:0000110)1.66357272
142Medulloblastoma (HP:0002885)1.66319208
143Male pseudohermaphroditism (HP:0000037)1.66145663
144Neoplasm of the oral cavity (HP:0100649)1.65979279
145Anencephaly (HP:0002323)1.65950539
146Sclerocornea (HP:0000647)1.65490860
147Cerebellar dysplasia (HP:0007033)1.65144794
148Methylmalonic acidemia (HP:0002912)1.65090692
149Poor suck (HP:0002033)1.64441339
150Preaxial hand polydactyly (HP:0001177)1.63871573
151Cystic liver disease (HP:0006706)1.63719207
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.61320070
153Narrow forehead (HP:0000341)1.61057165
154Rhinitis (HP:0012384)1.60683287
155Postaxial foot polydactyly (HP:0001830)1.60302675
156Increased hepatocellular lipid droplets (HP:0006565)1.58421355
157Papillary thyroid carcinoma (HP:0002895)1.57880271
158Failure to thrive in infancy (HP:0001531)1.57515638
159Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.57371963
160Fair hair (HP:0002286)1.57180180
161Hyperinsulinemic hypoglycemia (HP:0000825)1.56689872
162Chromosomal breakage induced by crosslinking agents (HP:0003221)1.56669448
163Median cleft lip (HP:0000161)1.55880399
164Tubulointerstitial nephritis (HP:0001970)1.55793281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.47467750
2EPHA43.47773826
3MAP3K42.82492705
4INSRR2.60665677
5CASK2.60218645
6PLK42.32691541
7MARK12.32617317
8MAP2K72.23976845
9MAP3K92.17845898
10MINK12.04631957
11PAK61.97448132
12NTRK21.97064624
13KSR11.96189814
14BMPR1B1.88192069
15TNIK1.78982341
16DAPK21.77716667
17CAMKK21.69879993
18ZAK1.66452291
19CDC71.64639118
20PRKD31.60495965
21CAMKK11.58273071
22PNCK1.57723615
23SGK4941.53517893
24SGK2231.53517893
25UHMK11.53297428
26TLK11.51924031
27AKT31.51633030
28PRPF4B1.47755073
29PBK1.45685077
30MAP2K41.40699044
31SGK21.39413766
32SIK31.36525953
33RIPK41.33578057
34STK391.33492991
35CDK51.33106182
36CDC42BPA1.32745241
37TRIM281.31141763
38MAP3K21.31000259
39MAPK131.30865352
40VRK11.30261236
41CAMK1G1.29456293
42NTRK11.27110747
43WNK41.25189348
44STK161.24853307
45STK381.24805216
46SRPK11.20710139
47BRD41.20627467
48SIK21.18491917
49IRAK21.18406071
50MAP4K21.18322682
51TSSK61.18247995
52WNK31.15201108
53BRSK21.15150083
54ACVR1B1.14789556
55FRK1.14638591
56HIPK21.14475174
57MKNK21.13779949
58PASK1.13138186
59ADRBK21.11152612
60PLK21.08729241
61CSNK1G11.08265406
62PRKCG1.06766678
63DYRK1A1.06095222
64DAPK11.02401710
65TYRO31.00737927
66SGK30.99709642
67WNK10.98104883
68KSR20.98061313
69STK38L0.97372591
70BCR0.96518919
71GRK50.95691125
72NEK60.94831296
73PLK30.92751599
74WEE10.91493983
75NME10.89414663
76MAPK150.87670313
77ERBB30.85701081
78PRKCH0.84852598
79SGK10.84517577
80BMPR20.84381652
81CAMK2B0.84234798
82CAMK2A0.83967752
83FGFR20.82916959
84MAP3K120.82292609
85STK110.78615554
86CSNK1G20.77723392
87CAMK10.77352287
88DYRK20.76917160
89CSNK1G30.76870792
90PINK10.76026513
91CAMK2D0.75634661
92RIPK10.74767757
93FES0.73440717
94PLK10.72997468
95CDK190.70820553
96CDK30.70104903
97OXSR10.70086904
98NUAK10.67591360
99ATM0.67430091
100PAK30.66495357
101TTK0.66145429
102STK30.65165002
103RET0.64775101
104ATR0.63641326
105PHKG20.63569733
106PHKG10.63569733
107CSNK1E0.62119464
108MARK20.61002027
109MAPK100.59792242
110CAMK1D0.58997201
111CDK180.58748822
112RPS6KA30.57588587
113RPS6KB10.55024500
114CAMK40.53558248
115EIF2AK30.53232947
116PRKCE0.52999464
117CDK150.51883212
118CSNK1A1L0.51074916
119MKNK10.51047351
120MST40.50388001
121PDGFRA0.49845719
122BRSK10.49672768
123MAP3K130.49665679
124IRAK10.49299963
125TAOK30.48302968
126GRK10.47914939
127CDK140.47530639
128NLK0.46829204
129CSNK1D0.46643166
130TNK20.45361335
131GSK3B0.45177258
132PRKDC0.45171124
133PRKAA10.44835676
134PRKCB0.44645985
135CCNB10.43597282
136RPS6KA50.43078769
137CDK80.42724397
138CDK11A0.42172503
139PRKCZ0.41740248
140YES10.41651211
141MELK0.39499114
142PRKACA0.39224456
143FER0.38787278
144MAP3K10.38758600

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.54877340
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12809373
3Circadian entrainment_Homo sapiens_hsa047132.80759851
4GABAergic synapse_Homo sapiens_hsa047272.77772290
5Phototransduction_Homo sapiens_hsa047442.72388061
6Insulin secretion_Homo sapiens_hsa049112.70317034
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68394075
8Morphine addiction_Homo sapiens_hsa050322.62168904
9Glutamatergic synapse_Homo sapiens_hsa047242.50779767
10Amphetamine addiction_Homo sapiens_hsa050312.45950686
11Olfactory transduction_Homo sapiens_hsa047402.43065125
12Long-term potentiation_Homo sapiens_hsa047202.37746975
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22688707
14Dopaminergic synapse_Homo sapiens_hsa047282.22346363
15Protein export_Homo sapiens_hsa030602.20964021
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13026983
17Basal transcription factors_Homo sapiens_hsa030222.11288686
18Selenocompound metabolism_Homo sapiens_hsa004502.10189385
19Butanoate metabolism_Homo sapiens_hsa006502.05051417
20Taste transduction_Homo sapiens_hsa047422.04125437
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.97522224
22Cholinergic synapse_Homo sapiens_hsa047251.96499681
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95920529
24Cocaine addiction_Homo sapiens_hsa050301.95875945
25Salivary secretion_Homo sapiens_hsa049701.87654754
26Serotonergic synapse_Homo sapiens_hsa047261.86892883
27Fanconi anemia pathway_Homo sapiens_hsa034601.81995712
28Long-term depression_Homo sapiens_hsa047301.72339696
29Renin secretion_Homo sapiens_hsa049241.70901691
30Non-homologous end-joining_Homo sapiens_hsa034501.68195284
31Oxidative phosphorylation_Homo sapiens_hsa001901.67727252
32Homologous recombination_Homo sapiens_hsa034401.65431309
33Type II diabetes mellitus_Homo sapiens_hsa049301.61759151
34Gastric acid secretion_Homo sapiens_hsa049711.48178509
35RNA degradation_Homo sapiens_hsa030181.47570532
36Mismatch repair_Homo sapiens_hsa034301.47262350
37RNA polymerase_Homo sapiens_hsa030201.45736993
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45665583
39Oxytocin signaling pathway_Homo sapiens_hsa049211.44396606
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43942057
41Collecting duct acid secretion_Homo sapiens_hsa049661.40040994
42Calcium signaling pathway_Homo sapiens_hsa040201.38877401
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37727947
44Circadian rhythm_Homo sapiens_hsa047101.36644628
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32624117
46GnRH signaling pathway_Homo sapiens_hsa049121.31885306
47Vibrio cholerae infection_Homo sapiens_hsa051101.28613706
48cAMP signaling pathway_Homo sapiens_hsa040241.22659401
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17034159
50Parkinsons disease_Homo sapiens_hsa050121.16472330
51Gap junction_Homo sapiens_hsa045401.15709087
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13620216
53Folate biosynthesis_Homo sapiens_hsa007901.13568127
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13174969
55Nucleotide excision repair_Homo sapiens_hsa034201.11247833
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09749280
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09085491
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07195980
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06341013
60Regulation of autophagy_Homo sapiens_hsa041401.04437890
61Ether lipid metabolism_Homo sapiens_hsa005651.03994276
62Estrogen signaling pathway_Homo sapiens_hsa049151.02329430
63RNA transport_Homo sapiens_hsa030131.02263193
64Pancreatic secretion_Homo sapiens_hsa049721.01929758
65Huntingtons disease_Homo sapiens_hsa050160.99921501
66Thyroid hormone synthesis_Homo sapiens_hsa049180.99681266
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99677305
68Caffeine metabolism_Homo sapiens_hsa002320.97478384
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95724632
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93577106
71Melanogenesis_Homo sapiens_hsa049160.93146477
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92577489
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.92345703
74Ribosome_Homo sapiens_hsa030100.91090158
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87520649
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86712398
77Glucagon signaling pathway_Homo sapiens_hsa049220.83752516
78Axon guidance_Homo sapiens_hsa043600.82730289
79Purine metabolism_Homo sapiens_hsa002300.81743251
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81600597
81Propanoate metabolism_Homo sapiens_hsa006400.80784348
82Cell cycle_Homo sapiens_hsa041100.80647556
83Basal cell carcinoma_Homo sapiens_hsa052170.80523528
84Type I diabetes mellitus_Homo sapiens_hsa049400.80303201
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80289989
86ErbB signaling pathway_Homo sapiens_hsa040120.79957130
87Linoleic acid metabolism_Homo sapiens_hsa005910.79824696
88Alcoholism_Homo sapiens_hsa050340.79038436
89mRNA surveillance pathway_Homo sapiens_hsa030150.78052528
90Alzheimers disease_Homo sapiens_hsa050100.77890579
91Choline metabolism in cancer_Homo sapiens_hsa052310.77707851
92Glioma_Homo sapiens_hsa052140.77595488
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76467037
94Base excision repair_Homo sapiens_hsa034100.76083461
95Cardiac muscle contraction_Homo sapiens_hsa042600.75455721
96Dorso-ventral axis formation_Homo sapiens_hsa043200.75098490
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.72480508
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72287213
99Inositol phosphate metabolism_Homo sapiens_hsa005620.71851800
100Steroid biosynthesis_Homo sapiens_hsa001000.71351102
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70726172
102Dilated cardiomyopathy_Homo sapiens_hsa054140.70258515
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70084996
104DNA replication_Homo sapiens_hsa030300.68381246
105Spliceosome_Homo sapiens_hsa030400.66627677
106Peroxisome_Homo sapiens_hsa041460.65008814
107Oocyte meiosis_Homo sapiens_hsa041140.64575860
108TGF-beta signaling pathway_Homo sapiens_hsa043500.64549174
109MAPK signaling pathway_Homo sapiens_hsa040100.64019509
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63601997
111Hippo signaling pathway_Homo sapiens_hsa043900.62698176
112mTOR signaling pathway_Homo sapiens_hsa041500.62583851
113Nitrogen metabolism_Homo sapiens_hsa009100.61714851
114Tryptophan metabolism_Homo sapiens_hsa003800.61492616
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61423727
116One carbon pool by folate_Homo sapiens_hsa006700.60999649
117Ovarian steroidogenesis_Homo sapiens_hsa049130.60873881
118Sulfur metabolism_Homo sapiens_hsa009200.60207494
119ABC transporters_Homo sapiens_hsa020100.58873211
120Pyrimidine metabolism_Homo sapiens_hsa002400.58737771
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57309491
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56297236
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.55841252
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55442940
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55347230
126Wnt signaling pathway_Homo sapiens_hsa043100.54733945
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54571906
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50400337
129Retinol metabolism_Homo sapiens_hsa008300.49725456
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49536268
131beta-Alanine metabolism_Homo sapiens_hsa004100.48514149
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48113999
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.46279059
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.45992540
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45603356
136Metabolic pathways_Homo sapiens_hsa011000.45583106
137Endometrial cancer_Homo sapiens_hsa052130.44796435
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42930198
139Insulin signaling pathway_Homo sapiens_hsa049100.42268029
140Ras signaling pathway_Homo sapiens_hsa040140.39998684
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.38063409
142Renal cell carcinoma_Homo sapiens_hsa052110.36148465
143Non-small cell lung cancer_Homo sapiens_hsa052230.32000328
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31374943
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30991694
146VEGF signaling pathway_Homo sapiens_hsa043700.30563083
147Rap1 signaling pathway_Homo sapiens_hsa040150.30250110
148Prolactin signaling pathway_Homo sapiens_hsa049170.30149119
149Bile secretion_Homo sapiens_hsa049760.30125181
150Hedgehog signaling pathway_Homo sapiens_hsa043400.26322731
151Chemokine signaling pathway_Homo sapiens_hsa040620.26228036
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25468233
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.25141023
154N-Glycan biosynthesis_Homo sapiens_hsa005100.24051606
155Prion diseases_Homo sapiens_hsa050200.22625196
156Colorectal cancer_Homo sapiens_hsa052100.20309289
157Lysine degradation_Homo sapiens_hsa003100.18991487
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.18751426
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18563209

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