EML6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31430813
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.99746460
3behavioral response to nicotine (GO:0035095)4.88669522
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80358631
5locomotory exploration behavior (GO:0035641)4.58178229
6synaptic vesicle maturation (GO:0016188)4.57724686
7synaptic vesicle exocytosis (GO:0016079)4.45832930
8L-fucose catabolic process (GO:0042355)4.44024322
9fucose catabolic process (GO:0019317)4.44024322
10L-fucose metabolic process (GO:0042354)4.44024322
11kynurenine metabolic process (GO:0070189)4.39165924
12vocalization behavior (GO:0071625)4.36623310
13tryptophan catabolic process (GO:0006569)4.34838322
14indole-containing compound catabolic process (GO:0042436)4.34838322
15indolalkylamine catabolic process (GO:0046218)4.34838322
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.33902137
17glutamate secretion (GO:0014047)4.33584263
18regulation of synaptic vesicle exocytosis (GO:2000300)4.31791674
19neuron cell-cell adhesion (GO:0007158)4.28282029
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.26929329
21glutamate receptor signaling pathway (GO:0007215)4.21890445
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17302107
23indolalkylamine metabolic process (GO:0006586)4.16817988
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.08815712
25regulation of glutamate receptor signaling pathway (GO:1900449)4.08059436
26synaptic transmission, glutamatergic (GO:0035249)4.03330655
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.01089726
28protein localization to synapse (GO:0035418)3.93274105
29regulation of synaptic vesicle transport (GO:1902803)3.88214589
30cellular ketone body metabolic process (GO:0046950)3.86866741
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86652904
32detection of light stimulus involved in visual perception (GO:0050908)3.77087654
33detection of light stimulus involved in sensory perception (GO:0050962)3.77087654
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71697008
35membrane depolarization during action potential (GO:0086010)3.71428781
36neuron-neuron synaptic transmission (GO:0007270)3.70320702
37neurotransmitter-gated ion channel clustering (GO:0072578)3.64057525
38cellular potassium ion homeostasis (GO:0030007)3.59539415
39exploration behavior (GO:0035640)3.58647249
40snRNA transcription (GO:0009301)3.57821134
41tryptophan metabolic process (GO:0006568)3.55161625
42signal peptide processing (GO:0006465)3.52182107
43protein K11-linked deubiquitination (GO:0035871)3.52069890
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51347867
45cerebellar Purkinje cell differentiation (GO:0021702)3.50462656
46long-term memory (GO:0007616)3.48843285
47neurotransmitter secretion (GO:0007269)3.47204612
48regulation of neuronal synaptic plasticity (GO:0048168)3.45788652
49ketone body metabolic process (GO:1902224)3.45645234
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.44876611
51indole-containing compound metabolic process (GO:0042430)3.37915538
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.34945291
53neuronal action potential propagation (GO:0019227)3.33051298
54regulation of hippo signaling (GO:0035330)3.31296586
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31073252
56synaptic vesicle endocytosis (GO:0048488)3.30775886
57response to pheromone (GO:0019236)3.30432036
58gamma-aminobutyric acid transport (GO:0015812)3.29075087
59presynaptic membrane assembly (GO:0097105)3.27696622
60positive regulation of membrane potential (GO:0045838)3.24439092
61piRNA metabolic process (GO:0034587)3.23581951
62DNA methylation involved in gamete generation (GO:0043046)3.22940527
63regulation of postsynaptic membrane potential (GO:0060078)3.22244748
64negative regulation of mast cell activation (GO:0033004)3.21540408
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.20914333
66primary amino compound metabolic process (GO:1901160)3.20635167
67serotonin metabolic process (GO:0042428)3.20395012
68dendrite morphogenesis (GO:0048813)3.19447281
69oxidative demethylation (GO:0070989)3.18829250
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17419946
71axoneme assembly (GO:0035082)3.17245349
72detection of calcium ion (GO:0005513)3.14946554
73neuron recognition (GO:0008038)3.13947458
74regulation of vesicle fusion (GO:0031338)3.11205227
75regulation of synapse structural plasticity (GO:0051823)3.10774637
76negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09326331
77calcium ion import (GO:0070509)3.08836091
78regulation of neurotransmitter secretion (GO:0046928)3.07242366
79membrane depolarization (GO:0051899)3.06823062
80positive regulation of synapse maturation (GO:0090129)3.06599766
81epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05777755
82axonal fasciculation (GO:0007413)3.04166376
83DNA deamination (GO:0045006)3.04132238
84calcium ion-dependent exocytosis (GO:0017156)3.02818821
85cilium or flagellum-dependent cell motility (GO:0001539)3.02650390
86dendritic spine morphogenesis (GO:0060997)3.02609217
87innervation (GO:0060384)3.02518949
88vesicle transport along microtubule (GO:0047496)3.02125334
89long-term synaptic potentiation (GO:0060291)3.01156232
90cellular response to ATP (GO:0071318)3.00973133
91activation of protein kinase A activity (GO:0034199)3.00926585
92neural tube formation (GO:0001841)3.00779003
93transmission of nerve impulse (GO:0019226)3.00516918
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98885798
95sodium ion export (GO:0071436)2.97288067
96interkinetic nuclear migration (GO:0022027)2.95254311
97postsynaptic membrane organization (GO:0001941)2.95173177
98presynaptic membrane organization (GO:0097090)2.94681851
99startle response (GO:0001964)2.94544247
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94421437
101adaptation of signaling pathway (GO:0023058)2.93980653
102regulation of synaptic plasticity (GO:0048167)2.93053164
103protein polyglutamylation (GO:0018095)2.92090388
104neuronal action potential (GO:0019228)2.91737211
105neurotransmitter transport (GO:0006836)2.90921681
106positive regulation of synaptic transmission, GABAergic (GO:0032230)2.89936622
107cerebellar granule cell differentiation (GO:0021707)2.89300779
108regulation of action potential (GO:0098900)2.88586453
109layer formation in cerebral cortex (GO:0021819)2.88387324
110L-amino acid import (GO:0043092)2.86609168
111proline transport (GO:0015824)2.85881417
112regulation of ARF protein signal transduction (GO:0032012)2.85209965
113sulfation (GO:0051923)2.85148871
114epithelial cilium movement (GO:0003351)2.84420426
115membrane hyperpolarization (GO:0060081)2.84141915
116reflex (GO:0060004)2.83012545
117cell communication by electrical coupling (GO:0010644)2.82604722
118response to auditory stimulus (GO:0010996)2.81658548
119nerve growth factor signaling pathway (GO:0038180)2.81086633
120response to histamine (GO:0034776)2.81002369
121regulation of neurotransmitter transport (GO:0051588)2.79606354
122chemosensory behavior (GO:0007635)2.78249464
123benzene-containing compound metabolic process (GO:0042537)2.78137798
124cellular sodium ion homeostasis (GO:0006883)2.77533523
125negative regulation of sodium ion transport (GO:0010766)2.77443826
126regulation of calcium ion-dependent exocytosis (GO:0017158)2.75421549
127adult walking behavior (GO:0007628)2.75409072
128prepulse inhibition (GO:0060134)2.75283929
129water-soluble vitamin biosynthetic process (GO:0042364)2.74774155
130L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72371597
131cellular biogenic amine catabolic process (GO:0042402)2.71774227
132amine catabolic process (GO:0009310)2.71774227
133aromatic amino acid family catabolic process (GO:0009074)2.71365922
134cilium movement (GO:0003341)2.70583685
135synapse assembly (GO:0007416)2.70558472
136negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70223926
137regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70148371
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.69132590
139kidney morphogenesis (GO:0060993)2.68329310
140glycerophospholipid catabolic process (GO:0046475)2.68216571
141rhodopsin mediated signaling pathway (GO:0016056)2.68187923
142long term synaptic depression (GO:0060292)2.68032976
143striatum development (GO:0021756)2.66625831
144neuromuscular process controlling posture (GO:0050884)2.63188765
145photoreceptor cell maintenance (GO:0045494)2.62226229
146multicellular organism reproduction (GO:0032504)2.62223041
147synaptic transmission (GO:0007268)2.61313801
148negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.61167364
149regulation of voltage-gated calcium channel activity (GO:1901385)2.60546558
150dopamine transport (GO:0015872)2.59651531
151neuromuscular process controlling balance (GO:0050885)2.59122370
152retinal cone cell development (GO:0046549)2.58839009
153cAMP catabolic process (GO:0006198)2.57687667
154regulation of neurotransmitter levels (GO:0001505)2.56960145
155regulation of dendritic spine morphogenesis (GO:0061001)2.56835399
156G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.56304727
157organelle transport along microtubule (GO:0072384)2.56167859
158learning (GO:0007612)2.55444979
159regulation of glucokinase activity (GO:0033131)2.55023994
160regulation of hexokinase activity (GO:1903299)2.55023994
161synapsis (GO:0007129)2.54278661
162positive regulation of neurotransmitter secretion (GO:0001956)2.54074572
163double-strand break repair via homologous recombination (GO:0000724)2.54010140
164cilium organization (GO:0044782)2.53154448
165recombinational repair (GO:0000725)2.51860295
166reciprocal meiotic recombination (GO:0007131)2.51567274
167reciprocal DNA recombination (GO:0035825)2.51567274
168somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50083367
169somatic hypermutation of immunoglobulin genes (GO:0016446)2.50083367
170male meiosis I (GO:0007141)2.49883118
171behavioral response to ethanol (GO:0048149)2.48904705
172nonmotile primary cilium assembly (GO:0035058)2.47736787
173neurotransmitter metabolic process (GO:0042133)2.46689193
174cilium assembly (GO:0042384)2.46308652
175insulin secretion (GO:0030073)2.45428872
176platelet dense granule organization (GO:0060155)2.45253238
177phosphatidylethanolamine metabolic process (GO:0046337)2.44442831
178cornea development in camera-type eye (GO:0061303)2.44200945
179positive regulation of oligodendrocyte differentiation (GO:0048714)2.44069203
180negative regulation of telomere maintenance (GO:0032205)2.43751891
181phosphatidylethanolamine biosynthetic process (GO:0006646)2.43009408
182regulation of cilium movement (GO:0003352)2.42449503
183NAD biosynthetic process (GO:0009435)2.41927515
184methionine biosynthetic process (GO:0009086)2.41267774
185spinal cord motor neuron differentiation (GO:0021522)2.41019386
186aromatic amino acid family metabolic process (GO:0009072)2.39968688
187cyclic nucleotide catabolic process (GO:0009214)2.38811902
188respiratory chain complex IV assembly (GO:0008535)2.38151607
189establishment of protein localization to Golgi (GO:0072600)2.37686357
190cilium morphogenesis (GO:0060271)2.36650024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01348705
2GBX2_23144817_ChIP-Seq_PC3_Human3.85253224
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.84925447
4DROSHA_22980978_ChIP-Seq_HELA_Human2.49032037
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44137513
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35318546
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33778968
8REST_21632747_ChIP-Seq_MESCs_Mouse2.27377413
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26771698
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09736244
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09058800
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02922456
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00384357
14* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97703511
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95316540
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95316540
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94932389
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.92295281
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89932216
20* RARB_27405468_Chip-Seq_BRAIN_Mouse1.89318017
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.88836914
22EWS_26573619_Chip-Seq_HEK293_Human1.85898846
23* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85861312
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85693978
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83323449
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81480421
27SMAD4_21799915_ChIP-Seq_A2780_Human1.78868273
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.76627295
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76494560
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75716617
31BCAT_22108803_ChIP-Seq_LS180_Human1.74629012
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.72471651
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.69985833
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69864121
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.69271655
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68717985
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.67765996
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.66467826
39TAF15_26573619_Chip-Seq_HEK293_Human1.61052427
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58439655
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56458196
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55387575
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54952546
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48997266
45IRF1_19129219_ChIP-ChIP_H3396_Human1.48918922
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48838337
47* STAT3_23295773_ChIP-Seq_U87_Human1.48588104
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48029695
49CBP_20019798_ChIP-Seq_JUKART_Human1.48029695
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46066315
51P300_19829295_ChIP-Seq_ESCs_Human1.45362681
52AR_21572438_ChIP-Seq_LNCaP_Human1.44318637
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42187156
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41633909
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.41518743
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41312995
57ZNF274_21170338_ChIP-Seq_K562_Hela1.39596502
58IGF1R_20145208_ChIP-Seq_DFB_Human1.39387738
59TCF4_22108803_ChIP-Seq_LS180_Human1.37458285
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37327463
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37271634
62TP53_22573176_ChIP-Seq_HFKS_Human1.37103114
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35882459
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35853430
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34170215
66TCF4_23295773_ChIP-Seq_U87_Human1.33935108
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.33374612
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.32949277
69AR_25329375_ChIP-Seq_VCAP_Human1.32235165
70SOX2_19829295_ChIP-Seq_ESCs_Human1.32043894
71NANOG_19829295_ChIP-Seq_ESCs_Human1.32043894
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29446981
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.28711826
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28537844
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27598541
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.26130877
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.25229983
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24317776
79* ARNT_22903824_ChIP-Seq_MCF-7_Human1.23596358
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23306259
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23187277
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22714282
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22697209
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22635421
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.22233939
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21943734
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21927370
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21692653
89* AHR_22903824_ChIP-Seq_MCF-7_Human1.21213379
90* FOXA1_25329375_ChIP-Seq_VCAP_Human1.20881251
91* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20881251
92AR_19668381_ChIP-Seq_PC3_Human1.17741596
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17284811
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17284811
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.17040935
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17030921
97TP53_16413492_ChIP-PET_HCT116_Human1.16869048
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15150368
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14981680
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.14440302
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13739886
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12794951
103* FLI1_21867929_ChIP-Seq_TH2_Mouse1.12351086
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11677127
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11266320
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10925774
107* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10592713
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10265389
109* CDX2_22108803_ChIP-Seq_LS180_Human1.10114117
110FUS_26573619_Chip-Seq_HEK293_Human1.09796008
111NCOR_22424771_ChIP-Seq_293T_Human1.08034391
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08002951
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07762820
114ER_23166858_ChIP-Seq_MCF-7_Human1.07405974
115RUNX2_22187159_ChIP-Seq_PCA_Human1.07302060
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07176934
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.05860060
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.05805708
119HOXB7_26014856_ChIP-Seq_BT474_Human1.05692130
120GATA3_21878914_ChIP-Seq_MCF-7_Human1.05108909
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.04797079
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04253240
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.03812678
124RNF2_27304074_Chip-Seq_NSC_Mouse1.03548338
125ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03543271
126* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02933078
127BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02264456
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.01133262
129KDM2B_26808549_Chip-Seq_REH_Human1.01131699
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00952825
131P53_22387025_ChIP-Seq_ESCs_Mouse1.00627407
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99607164
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98995471
134* AR_20517297_ChIP-Seq_VCAP_Human0.98682693
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97857043
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97587934
137* CRX_20693478_ChIP-Seq_RETINA_Mouse0.97135549
138PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96360149
139VDR_22108803_ChIP-Seq_LS180_Human0.95583584
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95549298
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94813652
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.94143456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.90210958
2MP0003880_abnormal_central_pattern4.25473125
3MP0003635_abnormal_synaptic_transmissio3.83871220
4MP0004270_analgesia3.59409370
5MP0003195_calcinosis3.25905004
6MP0009046_muscle_twitch3.21769890
7MP0009745_abnormal_behavioral_response3.13506491
8MP0002063_abnormal_learning/memory/cond3.04985970
9MP0002064_seizures2.91932364
10MP0002572_abnormal_emotion/affect_behav2.69567967
11MP0005423_abnormal_somatic_nervous2.66578986
12MP0001968_abnormal_touch/_nociception2.64454588
13MP0000569_abnormal_digit_pigmentation2.60626435
14MP0001984_abnormal_olfaction2.53269017
15MP0002734_abnormal_mechanical_nocicepti2.52220427
16MP0002272_abnormal_nervous_system2.50246925
17MP0001486_abnormal_startle_reflex2.46990233
18MP0003646_muscle_fatigue2.34405053
19MP0002735_abnormal_chemical_nociception2.32628018
20MP0003787_abnormal_imprinting2.24271280
21MP0001501_abnormal_sleep_pattern2.23946913
22MP0002909_abnormal_adrenal_gland2.03060105
23MP0002067_abnormal_sensory_capabilities1.98896333
24MP0002736_abnormal_nociception_after1.98894029
25MP0001986_abnormal_taste_sensitivity1.97074821
26MP0002822_catalepsy1.95053381
27MP0005551_abnormal_eye_electrophysiolog1.89120869
28MP0001440_abnormal_grooming_behavior1.85214315
29MP0005646_abnormal_pituitary_gland1.84613247
30MP0009780_abnormal_chondrocyte_physiolo1.82707475
31MP0005174_abnormal_tail_pigmentation1.80992534
32MP0000427_abnormal_hair_cycle1.80295102
33MP0008057_abnormal_DNA_replication1.79638565
34MP0008569_lethality_at_weaning1.78627785
35MP0002733_abnormal_thermal_nociception1.77999989
36MP0002184_abnormal_innervation1.77816890
37MP0000778_abnormal_nervous_system1.77682164
38MP0001970_abnormal_pain_threshold1.76916155
39MP0001502_abnormal_circadian_rhythm1.68649762
40MP0002557_abnormal_social/conspecific_i1.61407666
41MP0005645_abnormal_hypothalamus_physiol1.60230891
42MP0010386_abnormal_urinary_bladder1.57562426
43MP0008875_abnormal_xenobiotic_pharmacok1.55223423
44MP0003879_abnormal_hair_cell1.54696372
45MP0004924_abnormal_behavior1.54175584
46MP0005386_behavior/neurological_phenoty1.54175584
47MP0000383_abnormal_hair_follicle1.53721437
48MP0002102_abnormal_ear_morphology1.51378869
49MP0004858_abnormal_nervous_system1.50093612
50MP0004811_abnormal_neuron_physiology1.48943636
51MP0002882_abnormal_neuron_morphology1.45136701
52MP0003633_abnormal_nervous_system1.43221034
53MP0000955_abnormal_spinal_cord1.36832614
54MP0002160_abnormal_reproductive_system1.36763202
55MP0002229_neurodegeneration1.33116375
56MP0006292_abnormal_olfactory_placode1.31741709
57MP0005379_endocrine/exocrine_gland_phen1.30026936
58MP0005389_reproductive_system_phenotype1.29828257
59MP0002066_abnormal_motor_capabilities/c1.29712389
60MP0003329_amyloid_beta_deposits1.27168116
61MP0000372_irregular_coat_pigmentation1.25087759
62MP0002163_abnormal_gland_morphology1.25059118
63MP0004510_myositis1.23741042
64MP0006276_abnormal_autonomic_nervous1.22954263
65MP0004145_abnormal_muscle_electrophysio1.22023553
66MP0005410_abnormal_fertilization1.21960938
67MP0003136_yellow_coat_color1.19807239
68MP0004130_abnormal_muscle_cell1.19403531
69MP0002938_white_spotting1.18893419
70MP0000015_abnormal_ear_pigmentation1.17330189
71MP0003718_maternal_effect1.16959284
72MP0004885_abnormal_endolymph1.15913042
73MP0003631_nervous_system_phenotype1.15380202
74MP0005171_absent_coat_pigmentation1.13962993
75MP0001905_abnormal_dopamine_level1.12911042
76MP0004133_heterotaxia1.12242366
77MP0000538_abnormal_urinary_bladder1.11699739
78MP0010329_abnormal_lipoprotein_level1.10894389
79MP0004142_abnormal_muscle_tone1.10271249
80MP0002095_abnormal_skin_pigmentation1.08676628
81MP0005310_abnormal_salivary_gland1.08608156
82MP0001944_abnormal_pancreas_morphology1.08343094
83MP0003045_fibrosis1.07582181
84MP0003183_abnormal_peptide_metabolism1.07329502
85MP0001188_hyperpigmentation1.06993949
86MP0006072_abnormal_retinal_apoptosis1.06154275
87MP0003252_abnormal_bile_duct1.05943836
88MP0003283_abnormal_digestive_organ1.03253066
89MP0002090_abnormal_vision1.02651926
90MP0004147_increased_porphyrin_level1.02518416
91MP0010678_abnormal_skin_adnexa1.02215111
92MP0003011_delayed_dark_adaptation1.01015893
93MP0002928_abnormal_bile_duct1.00503384
94MP0002152_abnormal_brain_morphology0.99318728
95MP0005253_abnormal_eye_physiology0.98022766
96MP0003690_abnormal_glial_cell0.97906498
97MP0005266_abnormal_metabolism0.96900124
98MP0003634_abnormal_glial_cell0.96880431
99MP0005075_abnormal_melanosome_morpholog0.96578399
100MP0003172_abnormal_lysosome_physiology0.95686949
101MP0001529_abnormal_vocalization0.94335501
102MP0005085_abnormal_gallbladder_physiolo0.92533044
103MP0008877_abnormal_DNA_methylation0.92342924
104MP0004742_abnormal_vestibular_system0.91896311
105MP0002138_abnormal_hepatobiliary_system0.91274665
106MP0000230_abnormal_systemic_arterial0.90118367
107MP0000920_abnormal_myelination0.88244563
108MP0002752_abnormal_somatic_nervous0.86970060
109MP0002837_dystrophic_cardiac_calcinosis0.86813284
110MP0008995_early_reproductive_senescence0.86615319
111MP0002638_abnormal_pupillary_reflex0.85939054
112MP0008961_abnormal_basal_metabolism0.85830268
113MP0005332_abnormal_amino_acid0.85746382
114MP0001929_abnormal_gametogenesis0.84785864
115MP0000013_abnormal_adipose_tissue0.84430364
116MP0001919_abnormal_reproductive_system0.84360003
117MP0004085_abnormal_heartbeat0.82220283
118MP0003122_maternal_imprinting0.82015252
119MP0001299_abnormal_eye_distance/0.81504544
120MP0002069_abnormal_eating/drinking_beha0.80858998
121MP0005499_abnormal_olfactory_system0.80684735
122MP0005394_taste/olfaction_phenotype0.80684735
123MP0005535_abnormal_body_temperature0.79634369
124MP0001765_abnormal_ion_homeostasis0.79396047
125MP0003632_abnormal_nervous_system0.79270522
126MP0003075_altered_response_to0.78557312
127MP0002653_abnormal_ependyma_morphology0.78369951
128MP0002210_abnormal_sex_determination0.77972724
129MP0004043_abnormal_pH_regulation0.77091489
130MP0010234_abnormal_vibrissa_follicle0.76893864
131MP0005448_abnormal_energy_balance0.76758613
132MP0000631_abnormal_neuroendocrine_gland0.75371446
133MP0003953_abnormal_hormone_level0.74942106
134MP0001963_abnormal_hearing_physiology0.72271977
135MP0004215_abnormal_myocardial_fiber0.69946375
136MP0008874_decreased_physiological_sensi0.69826739
137MP0002693_abnormal_pancreas_physiology0.68048904
138MP0000751_myopathy0.67742918
139MP0005195_abnormal_posterior_eye0.65949970
140MP0001485_abnormal_pinna_reflex0.65229260
141MP0003137_abnormal_impulse_conducting0.63359612
142MP0003698_abnormal_male_reproductive0.63165916
143MP0002876_abnormal_thyroid_physiology0.59593163
144MP0001177_atelectasis0.59235284
145MP0008872_abnormal_physiological_respon0.59054348

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.05401638
2Focal seizures (HP:0007359)4.92283812
3Epileptic encephalopathy (HP:0200134)4.68776634
4Pancreatic cysts (HP:0001737)4.52991855
5Febrile seizures (HP:0002373)4.51010693
6Atonic seizures (HP:0010819)4.30887602
7Myokymia (HP:0002411)4.25518591
8Progressive cerebellar ataxia (HP:0002073)4.15988044
9Pancreatic fibrosis (HP:0100732)4.10141531
10Visual hallucinations (HP:0002367)3.92765766
11True hermaphroditism (HP:0010459)3.85174866
12Absence seizures (HP:0002121)3.83271812
13Molar tooth sign on MRI (HP:0002419)3.71814328
14Abnormality of midbrain morphology (HP:0002418)3.71814328
15Dialeptic seizures (HP:0011146)3.57444779
16Action tremor (HP:0002345)3.49312008
17Abnormality of the renal cortex (HP:0011035)3.41872541
18Gaze-evoked nystagmus (HP:0000640)3.41630454
19Generalized tonic-clonic seizures (HP:0002069)3.36409996
20Supranuclear gaze palsy (HP:0000605)3.34560744
21Broad-based gait (HP:0002136)3.29090966
22Nephronophthisis (HP:0000090)3.27358659
23Chronic hepatic failure (HP:0100626)3.23081312
24Truncal ataxia (HP:0002078)3.14379865
25Large for gestational age (HP:0001520)3.00221841
26Type II lissencephaly (HP:0007260)2.98399589
27Dysdiadochokinesis (HP:0002075)2.98191130
28Dysmetria (HP:0001310)2.98078067
29Central scotoma (HP:0000603)2.97795570
30Abnormality of the renal medulla (HP:0100957)2.93244872
31Cystic liver disease (HP:0006706)2.89704923
32Genetic anticipation (HP:0003743)2.88836772
33Excessive salivation (HP:0003781)2.81498814
34Drooling (HP:0002307)2.81498814
35Impaired smooth pursuit (HP:0007772)2.80023002
36Inability to walk (HP:0002540)2.79638923
37Tubular atrophy (HP:0000092)2.78216369
38Hemiparesis (HP:0001269)2.77880607
39Attenuation of retinal blood vessels (HP:0007843)2.75757855
40Abolished electroretinogram (ERG) (HP:0000550)2.73965792
41Furrowed tongue (HP:0000221)2.73441543
42Ankle clonus (HP:0011448)2.70665493
43Hyperventilation (HP:0002883)2.69742084
44Abnormal drinking behavior (HP:0030082)2.67310495
45Polydipsia (HP:0001959)2.67310495
46Absent/shortened dynein arms (HP:0200106)2.67136643
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.67136643
48Epileptiform EEG discharges (HP:0011182)2.65665555
49Decreased circulating renin level (HP:0003351)2.65253914
50Congenital, generalized hypertrichosis (HP:0004540)2.63840479
51Neurofibrillary tangles (HP:0002185)2.63813522
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.62672146
53Abnormality of ocular smooth pursuit (HP:0000617)2.57086087
54Congenital stationary night blindness (HP:0007642)2.55402131
55Urinary bladder sphincter dysfunction (HP:0002839)2.54837634
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.54030462
57Postural instability (HP:0002172)2.51154240
58Abnormality of macular pigmentation (HP:0008002)2.50934587
59Abnormality of alanine metabolism (HP:0010916)2.49901083
60Hyperalaninemia (HP:0003348)2.49901083
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49901083
62Mutism (HP:0002300)2.49191873
63Impaired vibration sensation in the lower limbs (HP:0002166)2.48389161
64Gait imbalance (HP:0002141)2.47567201
65EEG with generalized epileptiform discharges (HP:0011198)2.47032440
66Fair hair (HP:0002286)2.45973537
67Depression (HP:0000716)2.45114174
68Increased circulating renin level (HP:0000848)2.44831607
69Renal cortical cysts (HP:0000803)2.43436377
70Ketoacidosis (HP:0001993)2.41397411
71Pendular nystagmus (HP:0012043)2.35066834
72Absent speech (HP:0001344)2.34213950
73Cerebral inclusion bodies (HP:0100314)2.30981822
74Diplopia (HP:0000651)2.30206056
75Abnormality of binocular vision (HP:0011514)2.30206056
76Clumsiness (HP:0002312)2.27433618
77Blue irides (HP:0000635)2.27346740
78Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26318032
79Widely spaced teeth (HP:0000687)2.26239373
80Spastic gait (HP:0002064)2.25512702
81Abnormality of the corticospinal tract (HP:0002492)2.25007141
82Hypoplasia of the pons (HP:0012110)2.23758516
83Hypsarrhythmia (HP:0002521)2.22981825
84Protruding tongue (HP:0010808)2.21511827
85Congenital sensorineural hearing impairment (HP:0008527)2.21264283
86Abnormality of the pons (HP:0007361)2.20009880
87Sclerocornea (HP:0000647)2.18949481
88Ketosis (HP:0001946)2.17323147
89Bony spicule pigmentary retinopathy (HP:0007737)2.17193462
90Anxiety (HP:0000739)2.14541520
91Medial flaring of the eyebrow (HP:0010747)2.14467020
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.12875118
93Congenital primary aphakia (HP:0007707)2.11878663
94Intention tremor (HP:0002080)2.11855536
95Abnormal rod and cone electroretinograms (HP:0008323)2.10507719
96Aplasia/Hypoplasia of the patella (HP:0006498)2.09960956
97Patellar aplasia (HP:0006443)2.07585027
98Dysmetric saccades (HP:0000641)2.06820978
99Abnormal respiratory motile cilium physiology (HP:0012261)2.06792152
100Chorioretinal atrophy (HP:0000533)2.06777894
101Amblyopia (HP:0000646)2.06714518
102Abnormal eating behavior (HP:0100738)2.05875379
103Abnormal respiratory epithelium morphology (HP:0012253)2.05788550
104Abnormal respiratory motile cilium morphology (HP:0005938)2.05788550
105Poor eye contact (HP:0000817)2.05269529
106Abnormality of salivation (HP:0100755)2.04529264
107Increased corneal curvature (HP:0100692)2.04453008
108Keratoconus (HP:0000563)2.04453008
109Lissencephaly (HP:0001339)2.04426298
110Scanning speech (HP:0002168)2.04164094
111Lower limb muscle weakness (HP:0007340)2.03866805
112Papilledema (HP:0001085)2.02759798
113Bile duct proliferation (HP:0001408)2.02448395
114Abnormal biliary tract physiology (HP:0012439)2.02448395
115Nephrogenic diabetes insipidus (HP:0009806)2.02370550
116Polyuria (HP:0000103)2.02291049
117Congenital hepatic fibrosis (HP:0002612)2.00989648
118Male pseudohermaphroditism (HP:0000037)2.00745546
119Hyperkalemia (HP:0002153)1.99163323
120Hemiplegia (HP:0002301)1.99111881
121Cerebellar dysplasia (HP:0007033)1.97904107
122Anencephaly (HP:0002323)1.97715528
123Stereotypic behavior (HP:0000733)1.95012495
124Hypothermia (HP:0002045)1.94922342
125Decreased central vision (HP:0007663)1.93982337
126Impaired social interactions (HP:0000735)1.93578262
127Abnormal social behavior (HP:0012433)1.93578262
128Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93091845
129Prolonged QT interval (HP:0001657)1.90257374
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89845475
131Abnormality of the lower motor neuron (HP:0002366)1.89541557
132Inappropriate behavior (HP:0000719)1.89061934
133Abnormality of saccadic eye movements (HP:0000570)1.88884648
134Neuronal loss in central nervous system (HP:0002529)1.88037823
135Ventricular fibrillation (HP:0001663)1.87673123
136Syncope (HP:0001279)1.87176191
137Bradykinesia (HP:0002067)1.83562836
138Progressive inability to walk (HP:0002505)1.82416544
139Termporal pattern (HP:0011008)1.81870294
140Insidious onset (HP:0003587)1.81870294
141Abnormal ciliary motility (HP:0012262)1.81006240
142Postaxial foot polydactyly (HP:0001830)1.80398663
143Intestinal atresia (HP:0011100)1.79915770
144Hypomagnesemia (HP:0002917)1.79816675
145Retinal dysplasia (HP:0007973)1.79581302
146Impaired vibratory sensation (HP:0002495)1.79051112
147Bradycardia (HP:0001662)1.78792223
148Specific learning disability (HP:0001328)1.78222653
149Choroideremia (HP:0001139)1.77690005
150Lower limb amyotrophy (HP:0007210)1.77414134
151Open mouth (HP:0000194)1.76922037
152Abnormal albumin level (HP:0012116)1.76563942
153Hypoalbuminemia (HP:0003073)1.76563942
154Abnormal EKG (HP:0003115)1.76548470
155Generalized hypopigmentation of hair (HP:0011358)1.76358888
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75113361
157Urinary urgency (HP:0000012)1.74099798
158Genital tract atresia (HP:0001827)1.73825923
159Agitation (HP:0000713)1.73672631
160Scotoma (HP:0000575)1.73612814
161Hyperphosphatemia (HP:0002905)1.73568137
162Oligodactyly (hands) (HP:0001180)1.73230800
163Severe muscular hypotonia (HP:0006829)1.70858226
164Neoplasm of the adrenal cortex (HP:0100641)1.69575958
165Aplasia/Hypoplasia of the uvula (HP:0010293)1.68405396
166Stomach cancer (HP:0012126)1.68228702
167Aplasia/Hypoplasia of the spleen (HP:0010451)1.62493838
168Abnormal urine output (HP:0012590)1.62264963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.41316197
2EPHA43.29398728
3MAP3K93.12340249
4TNIK3.00237533
5MAP3K42.95897865
6MARK12.92871290
7BMPR1B2.81751219
8ZAK2.81611059
9ACVR1B2.72910811
10TLK12.62760724
11MAP2K72.57885776
12ADRBK22.54287440
13MAP4K22.38960213
14GRK12.33180159
15PRPF4B2.26778311
16CASK2.20679672
17RIPK42.08297369
18DAPK22.05279998
19WNK42.05242407
20PAK62.04880139
21MINK11.92238546
22NTRK21.88244922
23MAPK131.79542466
24PRKD31.67569619
25MAP2K41.53706443
26CDK51.43210196
27KSR21.41587110
28FGFR21.40494576
29STK381.40078472
30NTRK11.37668275
31NUAK11.36605755
32TRIM281.33680434
33SGK21.33595020
34FES1.28145164
35SGK4941.28027076
36SGK2231.28027076
37CAMKK11.24112556
38INSRR1.17479744
39MAP3K21.17056958
40MAPKAPK31.15139684
41BMPR21.14602377
42SIK21.14187652
43AKT31.12659490
44MAP3K131.12127633
45PLK21.11576452
46SGK31.09654778
47MKNK21.09292942
48DAPK11.08459008
49PRKCG1.05555039
50CAMK2A1.05319180
51CAMKK21.03976331
52KSR11.03409974
53ADRBK11.02585088
54MAP2K60.99262491
55SGK10.96850027
56WNK10.94928384
57TXK0.93476563
58PTK2B0.93389864
59CAMK2B0.93135136
60MARK20.90888968
61PKN10.90842485
62PHKG20.90731467
63PHKG10.90731467
64PAK30.90191598
65PRKCH0.89627973
66GRK50.86741523
67CAMK1G0.85547216
68NEK60.82877949
69UHMK10.82847778
70STK38L0.80458155
71OXSR10.78638393
72MST40.77846315
73ARAF0.77423729
74STK110.76478147
75NLK0.76459312
76CDC42BPA0.76100353
77TYRO30.74899905
78CAMK2D0.74777584
79PRKCE0.74302808
80MAP3K60.74156298
81RET0.73335950
82FER0.72326096
83FGR0.71249632
84PRKCI0.70091739
85CAMK10.69971160
86MAP3K120.68654504
87DYRK1A0.68281042
88PRKAA20.68188478
89PDK10.67843681
90TGFBR10.67384550
91PDPK10.66436451
92TEC0.65753656
93PNCK0.65274252
94RPS6KA50.63752445
95PIK3CG0.62762823
96ITK0.62503326
97MUSK0.59408183
98STK390.58984165
99TAOK30.58876505
100MAPKAPK50.58126144
101IKBKB0.57988204
102BRSK20.57603901
103VRK10.57216393
104RPS6KA30.56200942
105MAP3K10.55466162
106PRKCQ0.54816721
107JAK10.53595007
108CSNK1G10.52839570
109MAPK100.50778148
110TNK20.49961902
111PRKCZ0.49617849
112FYN0.49249965
113TRPM70.48617559
114MAP3K70.48207380
115MAP2K10.46442748
116PINK10.46225354
117CSNK1G20.45993756
118IRAK10.45854756
119CDK190.45005419
120SYK0.45003223
121WNK30.44158035
122CSNK1D0.43450094
123CDK180.43398265
124STK30.43389140
125CSNK1A10.43374404
126CDK150.42938214
127PDK40.42668588
128PDK30.42668588
129PRKCB0.41457702
130LMTK20.41136572
131CAMK40.39752860
132CAMK1D0.39341401
133RAF10.38894350
134PRKACA0.38448552
135CDK30.38332908
136CAMK2G0.38299872
137CHEK20.38149963
138PRKAA10.37724940
139PRKG10.37386586
140CDK140.37365620
141MAP3K140.36450611
142EIF2AK30.36287875
143NME10.35846484
144FRK0.35513912
145MAPK110.34252201
146PRKD20.34072352
147GSK3B0.33415559
148CSNK1G30.33391663
149PLK40.32151752
150MARK30.31538760
151CHUK0.30798791
152DYRK20.29700699
153PRKCA0.29562570
154ATR0.29361851
155MAPK150.29135245
156MAP4K10.28495903

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36191522
2Butanoate metabolism_Homo sapiens_hsa006502.96939239
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.91870064
4Synaptic vesicle cycle_Homo sapiens_hsa047212.77173202
5Circadian entrainment_Homo sapiens_hsa047132.63254981
6Olfactory transduction_Homo sapiens_hsa047402.59271545
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57503171
8GABAergic synapse_Homo sapiens_hsa047272.50732049
9Glutamatergic synapse_Homo sapiens_hsa047242.48612716
10Morphine addiction_Homo sapiens_hsa050322.42339640
11Linoleic acid metabolism_Homo sapiens_hsa005912.34929899
12Long-term potentiation_Homo sapiens_hsa047202.34405577
13Insulin secretion_Homo sapiens_hsa049112.23586592
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.19905163
15Tryptophan metabolism_Homo sapiens_hsa003802.13697145
16Amphetamine addiction_Homo sapiens_hsa050312.09131331
17Dopaminergic synapse_Homo sapiens_hsa047281.93712834
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93645389
19Selenocompound metabolism_Homo sapiens_hsa004501.93426503
20Taste transduction_Homo sapiens_hsa047421.93027146
21Salivary secretion_Homo sapiens_hsa049701.89265306
22Homologous recombination_Homo sapiens_hsa034401.87850389
23ABC transporters_Homo sapiens_hsa020101.87121765
24Cholinergic synapse_Homo sapiens_hsa047251.85064203
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83196350
26Type II diabetes mellitus_Homo sapiens_hsa049301.80500416
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78226036
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76111829
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74303625
30Renin secretion_Homo sapiens_hsa049241.69140776
31Serotonergic synapse_Homo sapiens_hsa047261.67530510
32Calcium signaling pathway_Homo sapiens_hsa040201.53633294
33Cocaine addiction_Homo sapiens_hsa050301.51514541
34Caffeine metabolism_Homo sapiens_hsa002321.49485557
35Gastric acid secretion_Homo sapiens_hsa049711.49269882
36Phototransduction_Homo sapiens_hsa047441.47909229
37Oxytocin signaling pathway_Homo sapiens_hsa049211.47432847
38Long-term depression_Homo sapiens_hsa047301.45424613
39Fanconi anemia pathway_Homo sapiens_hsa034601.43967950
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43205847
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.43034896
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42392974
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40062399
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38674470
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37390822
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.36824422
47cAMP signaling pathway_Homo sapiens_hsa040241.32750386
48GnRH signaling pathway_Homo sapiens_hsa049121.29866176
49Collecting duct acid secretion_Homo sapiens_hsa049661.24644785
50Glycerolipid metabolism_Homo sapiens_hsa005611.21323810
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21103076
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20367172
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.16628363
54Estrogen signaling pathway_Homo sapiens_hsa049151.15124233
55Chemical carcinogenesis_Homo sapiens_hsa052041.13725592
56Propanoate metabolism_Homo sapiens_hsa006401.13640555
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10363560
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10201982
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08386921
60Sulfur metabolism_Homo sapiens_hsa009201.08115624
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07474070
62Retinol metabolism_Homo sapiens_hsa008301.06119608
63One carbon pool by folate_Homo sapiens_hsa006701.01411133
64Pancreatic secretion_Homo sapiens_hsa049721.01036735
65RNA polymerase_Homo sapiens_hsa030201.00882638
66Gap junction_Homo sapiens_hsa045401.00750722
67Histidine metabolism_Homo sapiens_hsa003401.00358073
68Basal transcription factors_Homo sapiens_hsa030220.98940817
69ErbB signaling pathway_Homo sapiens_hsa040120.98280282
70Axon guidance_Homo sapiens_hsa043600.97452889
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96419816
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95864111
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.94847749
74Regulation of autophagy_Homo sapiens_hsa041400.94245550
75beta-Alanine metabolism_Homo sapiens_hsa004100.94169033
76Type I diabetes mellitus_Homo sapiens_hsa049400.91329487
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90684318
78Glioma_Homo sapiens_hsa052140.90669261
79Fat digestion and absorption_Homo sapiens_hsa049750.89103285
80Primary immunodeficiency_Homo sapiens_hsa053400.88487557
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.88193014
82Dilated cardiomyopathy_Homo sapiens_hsa054140.86830150
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86391184
84Vibrio cholerae infection_Homo sapiens_hsa051100.84619306
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82956502
86Fatty acid biosynthesis_Homo sapiens_hsa000610.82488627
87Inositol phosphate metabolism_Homo sapiens_hsa005620.82439994
88Dorso-ventral axis formation_Homo sapiens_hsa043200.81872204
89Circadian rhythm_Homo sapiens_hsa047100.81565731
90MAPK signaling pathway_Homo sapiens_hsa040100.77992478
91Arachidonic acid metabolism_Homo sapiens_hsa005900.76963863
92Thyroid hormone synthesis_Homo sapiens_hsa049180.76040952
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75485042
94Choline metabolism in cancer_Homo sapiens_hsa052310.73677368
95Melanogenesis_Homo sapiens_hsa049160.72259599
96Peroxisome_Homo sapiens_hsa041460.72259299
97Protein export_Homo sapiens_hsa030600.72119642
98Asthma_Homo sapiens_hsa053100.70957529
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70918234
100Systemic lupus erythematosus_Homo sapiens_hsa053220.68786273
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66479055
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.65995561
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64947907
104Ras signaling pathway_Homo sapiens_hsa040140.62136393
105VEGF signaling pathway_Homo sapiens_hsa043700.59465167
106Sphingolipid metabolism_Homo sapiens_hsa006000.59146849
107Chemokine signaling pathway_Homo sapiens_hsa040620.57982047
108Glucagon signaling pathway_Homo sapiens_hsa049220.57869170
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57529148
110Cardiac muscle contraction_Homo sapiens_hsa042600.56874697
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.56437814
112RNA degradation_Homo sapiens_hsa030180.55053468
113mTOR signaling pathway_Homo sapiens_hsa041500.55023887
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54412021
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53169849
116Oxidative phosphorylation_Homo sapiens_hsa001900.52614424
117Ovarian steroidogenesis_Homo sapiens_hsa049130.51876616
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51696525
119African trypanosomiasis_Homo sapiens_hsa051430.50756845
120Fatty acid degradation_Homo sapiens_hsa000710.50741327
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50665624
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50403383
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.49942011
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49480073
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49193489
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48391007
127Purine metabolism_Homo sapiens_hsa002300.47973925
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47363782
129Endometrial cancer_Homo sapiens_hsa052130.46489809
130Rap1 signaling pathway_Homo sapiens_hsa040150.46116462
131Prolactin signaling pathway_Homo sapiens_hsa049170.46034126
132Oocyte meiosis_Homo sapiens_hsa041140.45852118
133Sulfur relay system_Homo sapiens_hsa041220.44874894
134Rheumatoid arthritis_Homo sapiens_hsa053230.44181011
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44031024
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43431570
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41996202
138Endocytosis_Homo sapiens_hsa041440.41655048
139Prion diseases_Homo sapiens_hsa050200.40782818
140Metabolic pathways_Homo sapiens_hsa011000.40330535
141Lysine degradation_Homo sapiens_hsa003100.39965138
142Graft-versus-host disease_Homo sapiens_hsa053320.39802208
143Renal cell carcinoma_Homo sapiens_hsa052110.39707442
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.37145229
145Insulin signaling pathway_Homo sapiens_hsa049100.36765467
146Alcoholism_Homo sapiens_hsa050340.33792493
147Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33622235
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32696469
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31369311
150Bile secretion_Homo sapiens_hsa049760.30951926
151Mineral absorption_Homo sapiens_hsa049780.30827402
152Nitrogen metabolism_Homo sapiens_hsa009100.30488872
153Ether lipid metabolism_Homo sapiens_hsa005650.29321778
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29320133

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