EMP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.43386624
2surfactant homeostasis (GO:0043129)8.41246801
3chemical homeostasis within a tissue (GO:0048875)7.28668207
4hemidesmosome assembly (GO:0031581)6.10068119
5establishment of skin barrier (GO:0061436)5.06591964
6regulation of water loss via skin (GO:0033561)5.02459277
7multicellular organismal water homeostasis (GO:0050891)4.80607196
8sphingoid metabolic process (GO:0046519)4.63132909
9sphingosine metabolic process (GO:0006670)4.59027842
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.58937413
11intestinal epithelial cell development (GO:0060576)4.38245364
12keratinization (GO:0031424)4.36866361
13regulation of cardioblast differentiation (GO:0051890)4.34913762
14positive regulation of endothelial cell differentiation (GO:0045603)4.28500212
15dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.17459526
16water homeostasis (GO:0030104)4.13199004
17diol metabolic process (GO:0034311)4.09635121
18negative regulation of complement activation (GO:0045916)4.01902735
19lymphangiogenesis (GO:0001946)3.97788853
20keratinocyte differentiation (GO:0030216)3.96130319
21lymph vessel development (GO:0001945)3.94644979
22wound healing, spreading of epidermal cells (GO:0035313)3.90139623
23regulation of endothelial cell differentiation (GO:0045601)3.89654893
24norepinephrine metabolic process (GO:0042415)3.79787037
25keratinocyte proliferation (GO:0043616)3.78543976
26negative regulation of protein activation cascade (GO:2000258)3.65599889
27peptide cross-linking (GO:0018149)3.58372265
28glomerular visceral epithelial cell development (GO:0072015)3.55811854
29atrioventricular valve morphogenesis (GO:0003181)3.50447092
30glomerular epithelial cell development (GO:0072310)3.50164295
31keratinocyte development (GO:0003334)3.49720354
32trivalent inorganic anion homeostasis (GO:0072506)3.46469364
33phosphate ion homeostasis (GO:0055062)3.46469364
34negative regulation of keratinocyte proliferation (GO:0010839)3.42594469
35negative regulation of cell fate specification (GO:0009996)3.42317280
36lung lobe morphogenesis (GO:0060463)3.36875303
37tight junction assembly (GO:0070830)3.33048211
38endocrine hormone secretion (GO:0060986)3.23074412
39molting cycle (GO:0042303)3.22114452
40hair cycle (GO:0042633)3.22114452
41negative regulation of protein localization to cell surface (GO:2000009)3.21692030
42wound healing, spreading of cells (GO:0044319)3.21543264
43virion attachment to host cell (GO:0019062)3.21349994
44adhesion of symbiont to host cell (GO:0044650)3.21349994
45cellular response to nitric oxide (GO:0071732)3.19179101
46induction of positive chemotaxis (GO:0050930)3.19162036
47skin morphogenesis (GO:0043589)3.17425896
48regulation of glomerulus development (GO:0090192)3.14711055
49positive regulation of fatty acid beta-oxidation (GO:0032000)3.11767404
50positive regulation of fatty acid oxidation (GO:0046321)3.10262141
51gap junction assembly (GO:0016264)3.09338739
52striated muscle atrophy (GO:0014891)3.08702510
53epithelial cell-cell adhesion (GO:0090136)3.07824591
54epidermal cell differentiation (GO:0009913)3.04380857
55epidermis development (GO:0008544)3.02125100
56pharyngeal system development (GO:0060037)3.02104107
57mesodermal cell differentiation (GO:0048333)2.96170688
58cell adhesion mediated by integrin (GO:0033627)2.95496159
59flavonoid metabolic process (GO:0009812)2.95070138
60vascular endothelial growth factor signaling pathway (GO:0038084)2.93710445
61intermediate filament organization (GO:0045109)2.90744152
62ectoderm development (GO:0007398)2.88445462
63peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.87392641
64lateral sprouting from an epithelium (GO:0060601)2.86995135
65gland morphogenesis (GO:0022612)2.86128400
66cellular anion homeostasis (GO:0030002)2.85089482
67regulation of establishment or maintenance of cell polarity (GO:0032878)2.85052054
68negative regulation of humoral immune response (GO:0002921)2.84094446
69prostate gland growth (GO:0060736)2.83893287
70columnar/cuboidal epithelial cell development (GO:0002066)2.83159343
71positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.82215647
72respiratory tube development (GO:0030323)2.81933060
73cell-substrate junction assembly (GO:0007044)2.81582065
74negative regulation of systemic arterial blood pressure (GO:0003085)2.79526157
75regulation of cell proliferation involved in kidney development (GO:1901722)2.77935556
76lung alveolus development (GO:0048286)2.77096318
77regulation of hippo signaling (GO:0035330)2.77022827
78endothelial tube morphogenesis (GO:0061154)2.75586083
79morphogenesis of an endothelium (GO:0003159)2.75586083
80glomerular basement membrane development (GO:0032836)2.74740918
81negative regulation of stress fiber assembly (GO:0051497)2.73590917
82one-carbon compound transport (GO:0019755)2.73507516
83calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.73212224
84regulation of phospholipase A2 activity (GO:0032429)2.72983164
85regulation of ruffle assembly (GO:1900027)2.72905861
86cardiac right ventricle morphogenesis (GO:0003215)2.71524818
87blood vessel maturation (GO:0001955)2.70880896
88primary alcohol catabolic process (GO:0034310)2.70853268
89response to nitric oxide (GO:0071731)2.70850841
90establishment of epithelial cell polarity (GO:0090162)2.70508502
91regulation of keratinocyte proliferation (GO:0010837)2.70064005
92epithelial cell maturation (GO:0002070)2.68254066
93branching involved in salivary gland morphogenesis (GO:0060445)2.67801882
94negative regulation of axon extension involved in axon guidance (GO:0048843)2.67272696
95regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.66974184
96lung secretory cell differentiation (GO:0061140)2.66371210
97polarized epithelial cell differentiation (GO:0030859)2.66039630
98peptide catabolic process (GO:0043171)2.64578284
99toxin metabolic process (GO:0009404)2.64310728
100lung vasculature development (GO:0060426)2.63517826
101transepithelial transport (GO:0070633)2.62984087
102positive regulation of digestive system process (GO:0060456)2.61620980
103cell migration involved in sprouting angiogenesis (GO:0002042)2.61438194
104outflow tract septum morphogenesis (GO:0003148)2.60922431
105pattern specification involved in kidney development (GO:0061004)2.60514085
106blood vessel remodeling (GO:0001974)2.60423587
107ethanol metabolic process (GO:0006067)2.60388007
108regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.60382065
109regulation of cardioblast proliferation (GO:0003264)2.59317174
110regulation of secondary heart field cardioblast proliferation (GO:0003266)2.59317174
111adhesion of symbiont to host (GO:0044406)2.59151759
112regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.59114727
113negative regulation of cell fate commitment (GO:0010454)2.58773147
114regulation of fatty acid beta-oxidation (GO:0031998)2.57241642
115protein localization to endosome (GO:0036010)2.56775375
116artery development (GO:0060840)2.56720263
117cellular response to antibiotic (GO:0071236)2.56528797
118renal filtration (GO:0097205)2.56227250
119muscle atrophy (GO:0014889)2.56130026
120glomerular filtration (GO:0003094)2.55772778
121regulation of keratinocyte differentiation (GO:0045616)2.54964390
122regulation of chemokine secretion (GO:0090196)2.54600408
123regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.53627254
124heart valve morphogenesis (GO:0003179)2.53549565
125regulation of establishment of cell polarity (GO:2000114)2.53418694
126cell-cell junction assembly (GO:0007043)2.53007630
127endocardial cushion development (GO:0003197)2.52995277
128establishment of apical/basal cell polarity (GO:0035089)2.52397775
129regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.51914065
130cyclooxygenase pathway (GO:0019371)2.51289984
131regulation of axon extension involved in axon guidance (GO:0048841)2.49979532
132basement membrane organization (GO:0071711)2.49836611
133regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.47580869
134cellular response to reactive nitrogen species (GO:1902170)2.46501434
135regulation of transforming growth factor beta2 production (GO:0032909)2.46347999
136negative regulation of catenin import into nucleus (GO:0035414)2.46172023
137epithelial tube branching involved in lung morphogenesis (GO:0060441)2.45897199
138axon extension involved in axon guidance (GO:0048846)2.45668938
139neuron projection extension involved in neuron projection guidance (GO:1902284)2.45668938
140regulation of protein localization to cell surface (GO:2000008)2.45379024
141positive regulation of positive chemotaxis (GO:0050927)2.45332668
1423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.44833045
143purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.44833045
144regulation of cell fate specification (GO:0042659)2.43925652
145G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.43403649
146dorsal/ventral axis specification (GO:0009950)2.42671030
147iron ion import (GO:0097286)2.42543931
148response to xenobiotic stimulus (GO:0009410)2.42314523
149positive regulation of glomerulus development (GO:0090193)2.41963232
150positive regulation of p38MAPK cascade (GO:1900745)2.41942413
151cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41761075
152positive regulation of cartilage development (GO:0061036)2.41629925
153phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.41363570
154establishment of tissue polarity (GO:0007164)2.41305998
155establishment of planar polarity (GO:0001736)2.41305998
156cornea development in camera-type eye (GO:0061303)2.38738917
157phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38692466
158mesonephros development (GO:0001823)2.38446338
159regulation of fatty acid oxidation (GO:0046320)2.37467172
160smooth muscle tissue development (GO:0048745)2.37278298
161regulation of phospholipid biosynthetic process (GO:0071071)2.36989571
162phosphatidylserine acyl-chain remodeling (GO:0036150)2.36605936
163fibroblast migration (GO:0010761)2.36570672
164endothelial cell chemotaxis (GO:0035767)2.34491796
165negative regulation of kidney development (GO:0090185)2.32951315
166negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.31238220
167plasma membrane repair (GO:0001778)2.27715246
168glandular epithelial cell differentiation (GO:0002067)2.24769027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.97414572
2* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.09335034
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.85404678
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.73630329
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.51227817
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46534883
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.45111352
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.45100677
9* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.32832272
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18377149
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.98042771
12P63_26484246_Chip-Seq_KERATINOCYTES_Human1.97695969
13* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96064400
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.91193885
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.91193885
16CJUN_26792858_Chip-Seq_BT549_Human1.88959779
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.84304896
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.77919776
19PPAR_26484153_Chip-Seq_NCI-H1993_Human1.76901449
20SOX2_20726797_ChIP-Seq_SW620_Human1.76306767
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75188853
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72844046
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.70847407
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67999547
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.66794109
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62928073
27AHR_22903824_ChIP-Seq_MCF-7_Human1.62760689
28GATA1_22025678_ChIP-Seq_K562_Human1.61803483
29TP53_18474530_ChIP-ChIP_U2OS_Human1.61675666
30CLOCK_20551151_ChIP-Seq_293T_Human1.60790513
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60406762
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60391432
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59557164
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56193570
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48075091
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47785086
37ER_23166858_ChIP-Seq_MCF-7_Human1.46693680
38* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44029774
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43090727
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.42375148
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42097514
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40495158
43ZNF263_19887448_ChIP-Seq_K562_Human1.38632792
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38117457
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.38107884
46GATA4_25053715_ChIP-Seq_YYC3_Human1.37836909
47KLF5_25053715_ChIP-Seq_YYC3_Human1.35457850
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.34536631
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.33177992
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32773969
51VDR_22108803_ChIP-Seq_LS180_Human1.32386128
52* TP63_23658742_ChIP-Seq_EP156T_Human1.31271988
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29088576
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.28668058
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27556536
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.27373073
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26823090
58TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26797776
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26754237
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.26164229
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24907898
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.24849946
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22729197
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22392730
65* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21345934
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20297229
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20297229
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16698418
69GATA6_25053715_ChIP-Seq_YYC3_Human1.15660227
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15142479
71FOXA1_25552417_ChIP-Seq_VCAP_Human1.12752772
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12363894
73GATA3_24758297_ChIP-Seq_MCF-7_Human1.12352760
74* TBX20_22328084_ChIP-Seq_HEART_Mouse1.12170558
75* TBX20_22080862_ChIP-Seq_HEART_Mouse1.12170558
76GBX2_23144817_ChIP-Seq_PC3_Human1.11955803
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11885668
78* RACK7_27058665_Chip-Seq_MCF-7_Human1.11801332
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11090643
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11068935
81* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10996018
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10843828
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.10707206
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09940250
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09290400
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09290400
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.08739629
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.08705639
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08608893
90SMAD4_21799915_ChIP-Seq_A2780_Human1.07804387
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07496587
92* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07068586
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06925057
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.06214358
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04165569
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04078255
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03283374
98RXR_22108803_ChIP-Seq_LS180_Human1.02558182
99JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02525683
100BCAT_22108803_ChIP-Seq_LS180_Human1.02138274
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.01023273
102RXR_22158963_ChIP-Seq_LIVER_Mouse0.99583809
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98142811
104TP53_16413492_ChIP-PET_HCT116_Human0.98054081
105CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97671896
106* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97236618
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97165981
108* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96932188
109ATF3_27146783_Chip-Seq_COLON_Human0.96920287
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95530249
111CDX2_22108803_ChIP-Seq_LS180_Human0.95276389
112TCF4_22108803_ChIP-Seq_LS180_Human0.95140230
113EZH2_27304074_Chip-Seq_ESCs_Mouse0.94573783
114BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93748036
115* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93334583
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93287178
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93141428
118HOXB7_26014856_ChIP-Seq_BT474_Human0.93129576
119* STAT3_23295773_ChIP-Seq_U87_Human0.92514418
120RNF2_27304074_Chip-Seq_ESCs_Mouse0.91944059
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91818577
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91757903
123AR_25329375_ChIP-Seq_VCAP_Human0.91703929
124ELF5_23300383_ChIP-Seq_T47D_Human0.91256800
125AR_21572438_ChIP-Seq_LNCaP_Human0.91159823
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.90017317
127* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89558764
128* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89050449
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88797821
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87381496
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86589078
132EWS_26573619_Chip-Seq_HEK293_Human0.86245440
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85946082
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85409537
135FUS_26573619_Chip-Seq_HEK293_Human0.84947660
136* SMAD4_21741376_ChIP-Seq_HESCs_Human0.84273054
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84225884
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83893306
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83891917
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83495682
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82932642
142TAF15_26573619_Chip-Seq_HEK293_Human0.82161522
143BRD4_25478319_ChIP-Seq_HGPS_Human0.81925018
144JARID2_20064375_ChIP-Seq_MESCs_Mouse0.80967451
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80883729
146* TP63_22573176_ChIP-Seq_HFKS_Human0.80669331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier4.59834603
2MP0005275_abnormal_skin_tensile4.46021921
3MP0003941_abnormal_skin_development4.13901226
4MP0010234_abnormal_vibrissa_follicle3.94291074
5MP0004782_abnormal_surfactant_physiolog3.34272473
6MP0001958_emphysema3.30001219
7MP0002254_reproductive_system_inflammat2.90743679
8MP0010368_abnormal_lymphatic_system2.87482198
9MP0005501_abnormal_skin_physiology2.77219546
10MP0004272_abnormal_basement_membrane2.74798622
11MP0003705_abnormal_hypodermis_morpholog2.71137670
12MP0002098_abnormal_vibrissa_morphology2.59701680
13MP0002060_abnormal_skin_morphology2.54305613
14MP0000383_abnormal_hair_follicle2.46724503
15MP0010678_abnormal_skin_adnexa2.46529723
16MP0004264_abnormal_extraembryonic_tissu2.43640919
17MP0000579_abnormal_nail_morphology2.43551173
18MP0003566_abnormal_cell_adhesion2.32496560
19MP0000566_synostosis2.25013341
20MP0001879_abnormal_lymphatic_vessel2.23470175
21MP0002138_abnormal_hepatobiliary_system2.17702090
22MP0003453_abnormal_keratinocyte_physiol2.14020825
23MP0001216_abnormal_epidermal_layer2.12745867
24MP0009384_cardiac_valve_regurgitation2.05623102
25MP0010771_integument_phenotype1.87640581
26MP0004381_abnormal_hair_follicle1.86651716
27MP0000647_abnormal_sebaceous_gland1.86335147
28MP0001346_abnormal_lacrimal_gland1.81076808
29MP0000377_abnormal_hair_follicle1.77451774
30MP0008438_abnormal_cutaneous_collagen1.71786047
31MP0000762_abnormal_tongue_morphology1.70235157
32MP0005646_abnormal_pituitary_gland1.65969286
33MP0008995_early_reproductive_senescence1.64791393
34MP0000537_abnormal_urethra_morphology1.56917381
35MP0001542_abnormal_bone_strength1.55199547
36MP0000467_abnormal_esophagus_morphology1.54166624
37MP0008004_abnormal_stomach_pH1.51365724
38MP0002108_abnormal_muscle_morphology1.51078718
39MP0009379_abnormal_foot_pigmentation1.46378196
40MP0008875_abnormal_xenobiotic_pharmacok1.43547591
41MP0006054_spinal_hemorrhage1.41163934
42MP0002160_abnormal_reproductive_system1.39574805
43MP0002295_abnormal_pulmonary_circulatio1.39057049
44MP0005388_respiratory_system_phenotype1.38868446
45MP0002133_abnormal_respiratory_system1.38868446
46MP0004947_skin_inflammation1.34016878
47MP0004185_abnormal_adipocyte_glucose1.33598371
48MP0003828_pulmonary_edema1.30231733
49MP0002009_preneoplasia1.27996302
50MP0003950_abnormal_plasma_membrane1.23620807
51MP0003191_abnormal_cellular_cholesterol1.23329710
52MP0003091_abnormal_cell_migration1.23182350
53MP0000462_abnormal_digestive_system1.22526013
54MP0005367_renal/urinary_system_phenotyp1.20402979
55MP0000516_abnormal_urinary_system1.20402979
56MP0002234_abnormal_pharynx_morphology1.19847313
57MP0005451_abnormal_body_composition1.19658683
58MP0000427_abnormal_hair_cycle1.19445370
59MP0008775_abnormal_heart_ventricle1.19274447
60MP0005023_abnormal_wound_healing1.18613167
61MP0001661_extended_life_span1.16499007
62MP0000013_abnormal_adipose_tissue1.15680855
63MP0005623_abnormal_meninges_morphology1.15413972
64MP0001177_atelectasis1.14519751
65MP0003942_abnormal_urinary_system1.12113944
66MP0010030_abnormal_orbit_morphology1.11915782
67MP0004883_abnormal_blood_vessel1.11536626
68MP0005360_urolithiasis1.09108467
69MP0000767_abnormal_smooth_muscle1.06857231
70MP0003878_abnormal_ear_physiology1.05097320
71MP0005377_hearing/vestibular/ear_phenot1.05097320
72MP0003638_abnormal_response/metabolism_1.01630987
73MP0005508_abnormal_skeleton_morphology1.01513043
74MP0006138_congestive_heart_failure1.00587821
75MP0003279_aneurysm0.99783135
76MP0009931_abnormal_skin_appearance0.98552765
77MP0002132_abnormal_respiratory_system0.97629010
78MP0004043_abnormal_pH_regulation0.97577298
79MP0001191_abnormal_skin_condition0.97538303
80MP0001851_eye_inflammation0.97482388
81MP0003936_abnormal_reproductive_system0.97481040
82MP0003937_abnormal_limbs/digits/tail_de0.97351077
83MP0005595_abnormal_vascular_smooth0.96558579
84MP0010352_gastrointestinal_tract_polyps0.96358945
85MP0005167_abnormal_blood-brain_barrier0.95199868
86MP0002282_abnormal_trachea_morphology0.95120546
87MP0002249_abnormal_larynx_morphology0.94496196
88MP0004215_abnormal_myocardial_fiber0.93756489
89MP0001849_ear_inflammation0.93720629
90MP0002909_abnormal_adrenal_gland0.93638078
91MP0001756_abnormal_urination0.92942762
92MP0005409_darkened_coat_color0.92869481
93MP0000627_abnormal_mammary_gland0.92378184
94MP0009250_abnormal_appendicular_skeleto0.89089448
95MP0002277_abnormal_respiratory_mucosa0.87866088
96MP0002876_abnormal_thyroid_physiology0.87177537
97MP0009053_abnormal_anal_canal0.86058873
98MP0001485_abnormal_pinna_reflex0.85739455
99MP0003195_calcinosis0.85380943
100MP0005164_abnormal_response_to0.84599408
101MP0001664_abnormal_digestion0.84290317
102MP0004084_abnormal_cardiac_muscle0.83986201
103MP0003011_delayed_dark_adaptation0.82877817
104MP0005408_hypopigmentation0.82150565
105MP0000470_abnormal_stomach_morphology0.80411263
106MP0005503_abnormal_tendon_morphology0.80338815
107MP0005332_abnormal_amino_acid0.80056304
108MP0001243_abnormal_dermal_layer0.79654805
109MP0005085_abnormal_gallbladder_physiolo0.78628007
110MP0005389_reproductive_system_phenotype0.78067610
111MP0004036_abnormal_muscle_relaxation0.75366125
112MP0000534_abnormal_ureter_morphology0.75012472
113MP0000538_abnormal_urinary_bladder0.74971222
114MP0004085_abnormal_heartbeat0.74213638
115MP0003115_abnormal_respiratory_system0.71695476
116MP0005670_abnormal_white_adipose0.71166105
117MP0000465_gastrointestinal_hemorrhage0.71052249
118MP0005330_cardiomyopathy0.70857933
119MP0005248_abnormal_Harderian_gland0.70413112
120MP0004484_altered_response_of0.69946366
121MP0003045_fibrosis0.69348735
122MP0005165_increased_susceptibility_to0.68960618
123MP0000367_abnormal_coat/_hair0.68937754
124MP0000163_abnormal_cartilage_morphology0.68837329
125MP0001666_abnormal_nutrient_absorption0.68394514
126MP0001340_abnormal_eyelid_morphology0.68277320
127MP0000613_abnormal_salivary_gland0.67514971
128MP0002168_other_aberrant_phenotype0.67191969
129MP0005620_abnormal_muscle_contractility0.67031876
130MP0001175_abnormal_lung_morphology0.66078040
131MP0005551_abnormal_eye_electrophysiolog0.65938799
132MP0002877_abnormal_melanocyte_morpholog0.65424884
133MP0002233_abnormal_nose_morphology0.64574686
134MP0003724_increased_susceptibility_to0.62129924
135MP0001784_abnormal_fluid_regulation0.61887869
136MP0001544_abnormal_cardiovascular_syste0.58639345
137MP0005385_cardiovascular_system_phenoty0.58639345
138MP0005083_abnormal_biliary_tract0.58412113
139MP0003755_abnormal_palate_morphology0.58019257
140MP0002896_abnormal_bone_mineralization0.57995011
141MP0002925_abnormal_cardiovascular_devel0.57833254
142MP0009780_abnormal_chondrocyte_physiolo0.56863076

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)5.72442305
2Right ventricular cardiomyopathy (HP:0011663)5.26983165
3Fragile nails (HP:0001808)4.82780610
4Interstitial pulmonary disease (HP:0006530)4.62591720
5Hypotrichosis (HP:0001006)4.38707380
6Plantar hyperkeratosis (HP:0007556)4.22553355
7Atrophic scars (HP:0001075)4.12959701
8Milia (HP:0001056)4.04356248
9Woolly hair (HP:0002224)3.98900650
10Hyperactive renin-angiotensin system (HP:0000841)3.64669545
11Tachypnea (HP:0002789)3.62214080
12Chronic bronchitis (HP:0004469)3.32159389
13Broad metatarsal (HP:0001783)3.24768982
14Conjunctival hamartoma (HP:0100780)3.23486007
15Palmoplantar hyperkeratosis (HP:0000972)3.18641124
16Abnormality of the renal collecting system (HP:0004742)3.17590078
17Increased IgE level (HP:0003212)3.02324375
18Natal tooth (HP:0000695)3.01547194
19Hematochezia (HP:0002573)3.01452651
20Concave nail (HP:0001598)3.00703885
21Palmar hyperkeratosis (HP:0010765)2.99600744
22Hamartoma of the eye (HP:0010568)2.94802807
23Lip pit (HP:0100267)2.92275859
24Polycythemia (HP:0001901)2.91308705
25Shallow orbits (HP:0000586)2.89265518
26Decreased circulating renin level (HP:0003351)2.87735098
27Morphological abnormality of the middle ear (HP:0008609)2.86244361
28Congenital ichthyosiform erythroderma (HP:0007431)2.85963979
29Ventricular tachycardia (HP:0004756)2.81400022
30Aplasia involving bones of the upper limbs (HP:0009823)2.76974507
31Aplasia of the phalanges of the hand (HP:0009802)2.76974507
32Aplasia involving bones of the extremities (HP:0009825)2.76974507
33Premature rupture of membranes (HP:0001788)2.76465037
34Parakeratosis (HP:0001036)2.73350206
35Nail dystrophy (HP:0008404)2.73304571
36Abnormality of the nasal septum (HP:0000419)2.68845053
37Abnormal blistering of the skin (HP:0008066)2.68829064
38Tubular atrophy (HP:0000092)2.65551735
39Abnormality of nail color (HP:0100643)2.62883264
40Acanthosis nigricans (HP:0000956)2.61388404
41Abnormality of the proximal phalanges of the hand (HP:0009834)2.59776832
42Erythema (HP:0010783)2.59089320
43Popliteal pterygium (HP:0009756)2.59027516
44Advanced eruption of teeth (HP:0006288)2.56765473
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.55367268
46Hyporeflexia of lower limbs (HP:0002600)2.53019926
47Aortic aneurysm (HP:0004942)2.51595774
48Asymmetry of the thorax (HP:0001555)2.51530794
49Duplicated collecting system (HP:0000081)2.42958194
50Renal salt wasting (HP:0000127)2.41511380
51Aplasia of the musculature (HP:0100854)2.39692087
52Hyperkalemia (HP:0002153)2.39262198
53Pili torti (HP:0003777)2.37861397
54Abnormal umbilical cord blood vessels (HP:0011403)2.37832564
55Single umbilical artery (HP:0001195)2.37832564
56Abnormality of the fetal cardiovascular system (HP:0010948)2.37832564
57Curly hair (HP:0002212)2.34681491
58Bronchomalacia (HP:0002780)2.34475381
59Distal lower limb muscle weakness (HP:0009053)2.34290912
60Alopecia of scalp (HP:0002293)2.30505468
61Double outlet right ventricle (HP:0001719)2.27049088
62Congenital malformation of the right heart (HP:0011723)2.27049088
63Pterygium (HP:0001059)2.25799032
64Amelogenesis imperfecta (HP:0000705)2.20152666
65Furrowed tongue (HP:0000221)2.19831934
66Corneal erosion (HP:0200020)2.19789353
67Ankle contracture (HP:0006466)2.17361294
68Aplasia cutis congenita (HP:0001057)2.16882074
69Thick nail (HP:0001805)2.14763267
70Tubulointerstitial fibrosis (HP:0005576)2.13731249
71Follicular hyperkeratosis (HP:0007502)2.12676607
72Protrusio acetabuli (HP:0003179)2.10440652
73Vascular tortuosity (HP:0004948)2.09518253
74Abnormality of the frontal sinuses (HP:0002687)2.08588252
75Hypoplasia of dental enamel (HP:0006297)2.08337163
76Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.08063382
77Abnormality of the renal cortex (HP:0011035)2.07843760
78Abnormality of the gastric mucosa (HP:0004295)2.07531002
79Keratoconus (HP:0000563)2.07472448
80Increased corneal curvature (HP:0100692)2.07472448
81Bone cyst (HP:0012062)2.07108363
82Ulnar claw (HP:0001178)2.06061666
83Syncope (HP:0001279)2.05487947
84Vascular calcification (HP:0004934)2.04885726
85Depressed nasal tip (HP:0000437)2.03787437
86Abnormality of the axillary hair (HP:0100134)2.03127513
87Abnormality of secondary sexual hair (HP:0009888)2.03127513
88Palmoplantar keratoderma (HP:0000982)2.03127232
89Genetic anticipation (HP:0003743)2.03122615
90Down-sloping shoulders (HP:0200021)2.02562322
91Aplasia/Hypoplasia of the hallux (HP:0008362)2.02347426
92Respiratory distress (HP:0002098)2.01316613
93Camptodactyly of toe (HP:0001836)2.00186096
94Increased connective tissue (HP:0009025)1.99675760
95Fragile skin (HP:0001030)1.98364660
96Pulmonary artery stenosis (HP:0004415)1.97610763
97Pancreatic cysts (HP:0001737)1.97098550
98Neonatal short-limb short stature (HP:0008921)1.96464544
99Abnormality of the nasal mucosa (HP:0000433)1.95533094
100Blepharitis (HP:0000498)1.94694304
101Severe Myopia (HP:0011003)1.92517869
102Cardiovascular calcification (HP:0011915)1.91021394
103Tubulointerstitial abnormality (HP:0001969)1.89443457
104Esophageal varix (HP:0002040)1.87382326
105Absent eyebrow (HP:0002223)1.86827159
106Spinal rigidity (HP:0003306)1.85807364
107Sparse lateral eyebrow (HP:0005338)1.84896637
108Bicornuate uterus (HP:0000813)1.84165525
109Hypoplastic labia majora (HP:0000059)1.83944104
110Abnormality of the umbilical cord (HP:0010881)1.83538440
111Arterial tortuosity (HP:0005116)1.83308613
112Abnormality of renin-angiotensin system (HP:0000847)1.83182573
113Aortic dissection (HP:0002647)1.82856284
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.82612868
115Osteolytic defects of the hand bones (HP:0009699)1.82612868
116Thin bony cortex (HP:0002753)1.82496166
117Mildly elevated creatine phosphokinase (HP:0008180)1.81873895
118Abnormality of the labia majora (HP:0012881)1.81586840
119Visceral angiomatosis (HP:0100761)1.79556572
120Hyperventilation (HP:0002883)1.78797012
121Type 1 muscle fiber predominance (HP:0003803)1.78583664
122Abnormality of the ischium (HP:0003174)1.76772527
123Sudden death (HP:0001699)1.75508331
124Erythroderma (HP:0001019)1.75407870
125Synostosis involving the elbow (HP:0003938)1.73397627
126Humeroradial synostosis (HP:0003041)1.73397627
127Breast carcinoma (HP:0003002)1.73121700
128Abnormal hemoglobin (HP:0011902)1.72824810
129Short hallux (HP:0010109)1.72733353
130Spontaneous hematomas (HP:0007420)1.72379567
131Hemangiomatosis (HP:0007461)1.72135171
132Short 1st metacarpal (HP:0010034)1.71849184
133Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.71849184
134Abnormality of the distal phalanges of the toes (HP:0010182)1.71754792
135Septate vagina (HP:0001153)1.71628655
136Sparse eyelashes (HP:0000653)1.70970427
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.70900180
138Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70457510
139Ureteral duplication (HP:0000073)1.70234515
140Abnormality of the lacrimal duct (HP:0011481)1.69821054
141Goiter (HP:0000853)1.69497763
142Abnormal hair laboratory examination (HP:0003328)1.68565504
143Sparse scalp hair (HP:0002209)1.68157392
144Laryngomalacia (HP:0001601)1.68148802
145Congenital, generalized hypertrichosis (HP:0004540)1.67030345
146Abnormality of monocarboxylic acid metabolism (HP:0010996)1.66087354
147Lymphangioma (HP:0100764)1.66069425
148Pigmentary retinal degeneration (HP:0001146)1.65791343
149Abnormality of the middle phalanges of the toes (HP:0010183)1.64889177
150Absent frontal sinuses (HP:0002688)1.63845998
151Flat capital femoral epiphysis (HP:0003370)1.62658096
152Absent eyelashes (HP:0000561)1.62395435
153Fibular aplasia (HP:0002990)1.62353946
154Abnormality of the nasolacrimal system (HP:0000614)1.62010104
155J-shaped sella turcica (HP:0002680)1.60132877
156Cystic liver disease (HP:0006706)1.58956646
157Complement deficiency (HP:0004431)1.57590598
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.56327953
159Fatigable weakness (HP:0003473)1.55718773
160Abnormality of the neuromuscular junction (HP:0003398)1.55718773
161Bundle branch block (HP:0011710)1.54877007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.04043101
2MAP3K33.78970099
3MUSK3.71746266
4TIE13.71639518
5FER3.05043218
6STK392.92332962
7PIK3CA2.91415275
8LATS12.80757206
9TGFBR22.78388545
10EPHA22.52667548
11MST42.48313537
12PKN22.46127968
13MST1R2.40761238
14LRRK22.13430901
15EPHA32.08961656
16TRPM71.98614266
17TRIB31.97086402
18MAP3K21.87025667
19EPHB11.81243416
20STK241.79138517
21FGFR21.70094807
22MAPKAPK31.67796228
23STK101.63907328
24TTN1.59421282
25TESK11.59032918
26DMPK1.55952456
27LATS21.50547903
28TAOK11.44493414
29GRK11.44128706
30PTK61.42768208
31PDGFRA1.42264980
32OXSR11.37071655
33ACVR1B1.35751277
34MAP3K121.33643785
35MAP2K31.32353469
36MET1.28123816
37AKT31.26997686
38RPS6KA41.24559617
39DDR21.22416538
40EEF2K1.16531448
41MYLK1.16027633
42LMTK21.14134083
43LIMK11.13387642
44FGFR41.13262882
45TLK11.11764606
46TGFBR11.10311675
47PAK41.10162291
48ERBB31.09633867
49PTK21.09237681
50ADRBK21.07697434
51WNK41.06273619
52ERN11.06262226
53ILK1.05801750
54PRKD11.04558149
55PINK11.03151866
56RIPK11.01298198
57PDGFRB0.98772268
58MAP3K10.97676122
59BRSK20.96169079
60MOS0.95073611
61MELK0.94742491
62PIM20.94114993
63STK38L0.91776622
64MAP2K20.90947617
65NEK60.90660352
66NUAK10.89287315
67RPS6KA20.87657527
68TAOK20.86944469
69ROCK10.86408194
70NME10.81582573
71MAPK150.81011574
72NLK0.80154783
73EIF2AK30.79591207
74CDK60.78765287
75INSRR0.77971661
76STK30.77481447
77SIK10.74276106
78FGFR30.74275597
79MAP3K110.73146974
80NEK90.72516703
81BCR0.71211177
82RPS6KB20.70760206
83PRKCE0.67071398
84MAP2K10.66994096
85PBK0.65655679
86PIK3CG0.65469743
87ROCK20.64093137
88GSK3A0.63515037
89OBSCN0.63248300
90PAK30.61867444
91STK380.61136032
92GRK70.59601944
93DYRK1B0.58769630
94MTOR0.57008404
95PRKD20.56626968
96RPS6KB10.53927722
97KSR20.50774842
98HIPK20.47641239
99PDPK10.47610022
100ERBB40.47158402
101RPS6KA60.46154346
102BMPR1B0.45173298
103EGFR0.44860190
104MAPKAPK20.43975693
105CSK0.41466725
106KDR0.40959871
107ERBB20.40752050
108EIF2AK10.40695775
109CAMK2D0.40378982
110FGFR10.39617428
111PDK20.37671820
112PHKG10.36798812
113PHKG20.36798812
114ABL10.36705014
115MAP3K70.36687111
116MAP3K80.36166179
117CDC42BPA0.35900110
118MAP2K60.35168730
119GRK50.35165559
120CAMK2B0.35070801
121CAMK2G0.35027460
122EIF2AK20.34341682
123PAK20.33961725
124FRK0.33224290
125DAPK20.32796922
126CHUK0.32172891
127ABL20.30745214
128CDK80.30592829
129ADRBK10.29899304
130BMX0.29258136
131RPS6KL10.28529303
132RPS6KC10.28529303
133MARK20.26567008
134IGF1R0.26319467
135PRKAA20.25289634
136MAPKAPK50.24964471
137SGK20.24848734
138PRKCI0.23719001

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.34892708
2Adherens junction_Homo sapiens_hsa045202.76864710
3Tight junction_Homo sapiens_hsa045302.35701322
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.34260660
5Tryptophan metabolism_Homo sapiens_hsa003802.33866359
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21214680
7Hippo signaling pathway_Homo sapiens_hsa043902.16995394
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.10438568
9Sphingolipid metabolism_Homo sapiens_hsa006002.07314528
10Focal adhesion_Homo sapiens_hsa045102.04489171
11Bladder cancer_Homo sapiens_hsa052192.01530014
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.92195767
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.90045732
14Basal cell carcinoma_Homo sapiens_hsa052171.83670652
15TGF-beta signaling pathway_Homo sapiens_hsa043501.80065051
16Nitrogen metabolism_Homo sapiens_hsa009101.79431501
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77626815
18Proteoglycans in cancer_Homo sapiens_hsa052051.75811704
19Tyrosine metabolism_Homo sapiens_hsa003501.74878181
20Sulfur metabolism_Homo sapiens_hsa009201.71604868
21Amoebiasis_Homo sapiens_hsa051461.69354941
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.69202842
23Small cell lung cancer_Homo sapiens_hsa052221.64880018
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61843374
25Fatty acid degradation_Homo sapiens_hsa000711.60196354
26Dilated cardiomyopathy_Homo sapiens_hsa054141.59002178
27beta-Alanine metabolism_Homo sapiens_hsa004101.55791117
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.53512832
29Axon guidance_Homo sapiens_hsa043601.51544099
30Selenocompound metabolism_Homo sapiens_hsa004501.47580274
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46999603
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41430683
33Mineral absorption_Homo sapiens_hsa049781.38923107
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38339748
35Vitamin digestion and absorption_Homo sapiens_hsa049771.37945913
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.29030335
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.27436903
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26028921
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25072030
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22414663
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22048710
42Rap1 signaling pathway_Homo sapiens_hsa040151.20734283
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19299424
44Arachidonic acid metabolism_Homo sapiens_hsa005901.18413437
45Melanogenesis_Homo sapiens_hsa049161.16647086
46Histidine metabolism_Homo sapiens_hsa003401.16181949
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16108034
48Hedgehog signaling pathway_Homo sapiens_hsa043401.15650404
49Retinol metabolism_Homo sapiens_hsa008301.14291645
50MicroRNAs in cancer_Homo sapiens_hsa052061.14001098
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11875216
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11394249
53Chemical carcinogenesis_Homo sapiens_hsa052041.10934247
54PPAR signaling pathway_Homo sapiens_hsa033201.09319424
55Linoleic acid metabolism_Homo sapiens_hsa005911.08908381
56VEGF signaling pathway_Homo sapiens_hsa043701.08120729
57Protein digestion and absorption_Homo sapiens_hsa049741.08113895
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07016734
59Phototransduction_Homo sapiens_hsa047441.06778738
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06220234
61Malaria_Homo sapiens_hsa051441.04183406
62Ether lipid metabolism_Homo sapiens_hsa005651.03378006
63Caffeine metabolism_Homo sapiens_hsa002321.01611024
64Toxoplasmosis_Homo sapiens_hsa051451.00285820
65Pathways in cancer_Homo sapiens_hsa052000.96884251
66Melanoma_Homo sapiens_hsa052180.96809489
67Fatty acid elongation_Homo sapiens_hsa000620.95978724
68Bile secretion_Homo sapiens_hsa049760.94318571
69Dorso-ventral axis formation_Homo sapiens_hsa043200.94128628
70Butanoate metabolism_Homo sapiens_hsa006500.92894544
71Renal cell carcinoma_Homo sapiens_hsa052110.91530912
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.90083233
73Prostate cancer_Homo sapiens_hsa052150.87045411
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86384603
75GnRH signaling pathway_Homo sapiens_hsa049120.85249013
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.84522863
77Wnt signaling pathway_Homo sapiens_hsa043100.83608189
78Ras signaling pathway_Homo sapiens_hsa040140.82886343
79Hepatitis C_Homo sapiens_hsa051600.82847563
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.82522395
81Platelet activation_Homo sapiens_hsa046110.82157881
82Pancreatic cancer_Homo sapiens_hsa052120.81951779
83Pertussis_Homo sapiens_hsa051330.79970053
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79440345
85Taste transduction_Homo sapiens_hsa047420.79394947
86Insulin resistance_Homo sapiens_hsa049310.78841823
87Endometrial cancer_Homo sapiens_hsa052130.78219823
88Ovarian steroidogenesis_Homo sapiens_hsa049130.78026809
89Fatty acid biosynthesis_Homo sapiens_hsa000610.77551413
90Renin secretion_Homo sapiens_hsa049240.77518967
91Phenylalanine metabolism_Homo sapiens_hsa003600.77288287
92Notch signaling pathway_Homo sapiens_hsa043300.75800066
93Endocytosis_Homo sapiens_hsa041440.73906455
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69833827
95Lysine degradation_Homo sapiens_hsa003100.69718200
96Thyroid cancer_Homo sapiens_hsa052160.69345829
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69059064
98Viral myocarditis_Homo sapiens_hsa054160.67908734
99Lysosome_Homo sapiens_hsa041420.66056481
100Arginine biosynthesis_Homo sapiens_hsa002200.65348037
101TNF signaling pathway_Homo sapiens_hsa046680.64672657
102Starch and sucrose metabolism_Homo sapiens_hsa005000.64650533
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63239026
104Fat digestion and absorption_Homo sapiens_hsa049750.62746860
105Gastric acid secretion_Homo sapiens_hsa049710.62072834
106Propanoate metabolism_Homo sapiens_hsa006400.61047146
107Peroxisome_Homo sapiens_hsa041460.60489523
108Glutathione metabolism_Homo sapiens_hsa004800.59912970
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.59758802
110Sulfur relay system_Homo sapiens_hsa041220.59743955
111Glycerolipid metabolism_Homo sapiens_hsa005610.59490779
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59113098
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58913718
114Phagosome_Homo sapiens_hsa041450.58442277
115Cardiac muscle contraction_Homo sapiens_hsa042600.57687249
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55952647
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.54479790
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52572482
119Circadian rhythm_Homo sapiens_hsa047100.52449604
120Complement and coagulation cascades_Homo sapiens_hsa046100.52315334
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.52056642
122Serotonergic synapse_Homo sapiens_hsa047260.51692313
123Salivary secretion_Homo sapiens_hsa049700.51504399
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49818695
125Salmonella infection_Homo sapiens_hsa051320.49157474
126Steroid biosynthesis_Homo sapiens_hsa001000.49073956
127HTLV-I infection_Homo sapiens_hsa051660.48671117
128Fatty acid metabolism_Homo sapiens_hsa012120.48605176
129Glioma_Homo sapiens_hsa052140.48302668
130Chronic myeloid leukemia_Homo sapiens_hsa052200.48268406
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.46611407
132Estrogen signaling pathway_Homo sapiens_hsa049150.45094428
133Pancreatic secretion_Homo sapiens_hsa049720.42878554
134Gap junction_Homo sapiens_hsa045400.42803909
135Renin-angiotensin system_Homo sapiens_hsa046140.41551394
136Arginine and proline metabolism_Homo sapiens_hsa003300.40422353
137ErbB signaling pathway_Homo sapiens_hsa040120.40256434
138Apoptosis_Homo sapiens_hsa042100.38226465
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38043644
140Rheumatoid arthritis_Homo sapiens_hsa053230.38010553
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37532260
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37274231
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.37023375
144Oxytocin signaling pathway_Homo sapiens_hsa049210.36753113
145p53 signaling pathway_Homo sapiens_hsa041150.36655080
146ABC transporters_Homo sapiens_hsa020100.36542677
147Calcium signaling pathway_Homo sapiens_hsa040200.36297430
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.35920561
149FoxO signaling pathway_Homo sapiens_hsa040680.35056025
150Insulin secretion_Homo sapiens_hsa049110.33435496
151AMPK signaling pathway_Homo sapiens_hsa041520.33038417
152N-Glycan biosynthesis_Homo sapiens_hsa005100.31187917
153Metabolic pathways_Homo sapiens_hsa011000.30802026

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