EMX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glutamate secretion (GO:0014047)5.87235153
2pyrimidine nucleobase catabolic process (GO:0006208)5.38589957
3negative regulation of telomerase activity (GO:0051974)5.27572816
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.26143674
5protein localization to synapse (GO:0035418)5.24464411
6vocalization behavior (GO:0071625)5.23260295
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.14776904
8DNA damage induced protein phosphorylation (GO:0006975)5.13218020
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01151815
10synaptic vesicle exocytosis (GO:0016079)5.00984096
11layer formation in cerebral cortex (GO:0021819)4.98055119
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87759033
13synaptic vesicle maturation (GO:0016188)4.87143274
14locomotory exploration behavior (GO:0035641)4.80137489
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.79908177
16exploration behavior (GO:0035640)4.74292516
17regulation of glutamate receptor signaling pathway (GO:1900449)4.67856186
18nucleobase catabolic process (GO:0046113)4.58955316
19regulation of DNA methylation (GO:0044030)4.46612118
20regulation of synaptic vesicle exocytosis (GO:2000300)4.35636793
21neuron recognition (GO:0008038)4.32407118
22dendritic spine morphogenesis (GO:0060997)4.31182028
23regulation of telomere maintenance via telomerase (GO:0032210)4.30135579
24axonal fasciculation (GO:0007413)4.24180906
25L-amino acid import (GO:0043092)4.18654585
26neuron cell-cell adhesion (GO:0007158)4.16015494
27regulation of telomerase activity (GO:0051972)4.07486546
28positive regulation of synapse maturation (GO:0090129)4.05181328
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.89451656
30phosphate ion transport (GO:0006817)3.87282405
31negative regulation of telomere maintenance (GO:0032205)3.83439776
32regulation of synaptic vesicle transport (GO:1902803)3.82512453
33regulation of synapse structural plasticity (GO:0051823)3.81458609
34positive regulation of membrane potential (GO:0045838)3.80292051
35regulation of helicase activity (GO:0051095)3.79416434
36neurotransmitter-gated ion channel clustering (GO:0072578)3.76673395
37regulation of neuronal synaptic plasticity (GO:0048168)3.75505228
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74168069
39regulation of dendritic spine morphogenesis (GO:0061001)3.71869698
40regulation of meiosis I (GO:0060631)3.67738995
41glutamate receptor signaling pathway (GO:0007215)3.65413128
42proline transport (GO:0015824)3.64329089
43central nervous system projection neuron axonogenesis (GO:0021952)3.63532192
44postsynaptic membrane organization (GO:0001941)3.62566375
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60596239
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.59800808
47axon ensheathment in central nervous system (GO:0032291)3.59564117
48central nervous system myelination (GO:0022010)3.59564117
49neurotransmitter secretion (GO:0007269)3.58623287
50response to acidic pH (GO:0010447)3.57103372
51aminoglycoside antibiotic metabolic process (GO:0030647)3.53040004
52drug transmembrane transport (GO:0006855)3.50408949
53retinal cone cell development (GO:0046549)3.49868588
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49404939
55ventricular trabecula myocardium morphogenesis (GO:0003222)3.47846893
56ionotropic glutamate receptor signaling pathway (GO:0035235)3.47469228
57neuronal action potential propagation (GO:0019227)3.47093531
58negative regulation of astrocyte differentiation (GO:0048712)3.38139224
59dendrite morphogenesis (GO:0048813)3.34711853
60synaptic transmission, glutamatergic (GO:0035249)3.33441323
61transmission of nerve impulse (GO:0019226)3.33351541
62cell proliferation in forebrain (GO:0021846)3.32014668
63dendritic spine organization (GO:0097061)3.27770458
64piRNA metabolic process (GO:0034587)3.26330988
65cerebral cortex radially oriented cell migration (GO:0021799)3.26317788
66regulation of postsynaptic membrane potential (GO:0060078)3.25746612
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.25638881
68metanephric nephron tubule development (GO:0072234)3.25075212
69metanephric tubule development (GO:0072170)3.25075212
70regulation of dendritic spine development (GO:0060998)3.23216618
71negative regulation of microtubule polymerization (GO:0031115)3.22955036
72urate metabolic process (GO:0046415)3.22842913
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22197952
74neuron-neuron synaptic transmission (GO:0007270)3.20041757
75synaptic vesicle endocytosis (GO:0048488)3.19711067
76presynaptic membrane assembly (GO:0097105)3.18112566
77cellular potassium ion homeostasis (GO:0030007)3.15585400
78cell migration in hindbrain (GO:0021535)3.14263123
79positive regulation of dendritic spine development (GO:0060999)3.13272245
80lysine catabolic process (GO:0006554)3.11859358
81lysine metabolic process (GO:0006553)3.11859358
82regulation of synaptic plasticity (GO:0048167)3.11808380
83positive regulation of neurotransmitter secretion (GO:0001956)3.10758721
84negative regulation of transcription regulatory region DNA binding (GO:2000678)3.10591893
85phosphorelay signal transduction system (GO:0000160)3.06670355
86phosphate ion transmembrane transport (GO:0035435)3.06621083
87amino acid import (GO:0043090)3.04707159
88organic cation transport (GO:0015695)3.04057088
89regulation of female receptivity (GO:0045924)3.03018949
90DNA damage response, detection of DNA damage (GO:0042769)3.02579571
91response to parathyroid hormone (GO:0071107)3.02387270
92cellular ketone body metabolic process (GO:0046950)3.00518690
93neurotransmitter transport (GO:0006836)3.00391931
94meiotic cell cycle (GO:0051321)3.00099256
95metanephric nephron epithelium development (GO:0072243)2.99587043
96sodium ion export (GO:0071436)2.99110746
97regulation of synapse maturation (GO:0090128)2.97278121
98behavioral defense response (GO:0002209)2.95331869
99behavioral fear response (GO:0001662)2.95331869
100negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.94333261
101ephrin receptor signaling pathway (GO:0048013)2.93143379
102establishment of nucleus localization (GO:0040023)2.89700963
103regulation of neurotransmitter secretion (GO:0046928)2.89341446
104cell communication by electrical coupling (GO:0010644)2.89126999
105regulation of synaptic transmission, glutamatergic (GO:0051966)2.87349369
106presynaptic membrane organization (GO:0097090)2.83279906
107activation of protein kinase A activity (GO:0034199)2.83160460
108membrane hyperpolarization (GO:0060081)2.83074548
109axon extension (GO:0048675)2.83032687
110long-term memory (GO:0007616)2.81894970
111central nervous system neuron axonogenesis (GO:0021955)2.81300183
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81099587
113membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.80988249
114positive regulation of meiosis (GO:0045836)2.80387952
115long-term synaptic potentiation (GO:0060291)2.79546406
116drug transport (GO:0015893)2.78771201
117neuron fate determination (GO:0048664)2.76516337
118fear response (GO:0042596)2.76274856
119dicarboxylic acid transport (GO:0006835)2.74537013
120neuronal ion channel clustering (GO:0045161)2.74070839
121auditory behavior (GO:0031223)2.73959702
122hippocampus development (GO:0021766)2.73007769
123metanephric epithelium development (GO:0072207)2.72260872
124adult walking behavior (GO:0007628)2.72037417
125cochlea development (GO:0090102)2.71448635
126gamma-aminobutyric acid signaling pathway (GO:0007214)2.71299177
127DNA replication checkpoint (GO:0000076)2.71211391
128artery development (GO:0060840)2.71050592
129cerebellar granule cell differentiation (GO:0021707)2.70626674
130cellular response to pH (GO:0071467)2.70518712
131tongue development (GO:0043586)2.69684883
132regulation of calcium ion-dependent exocytosis (GO:0017158)2.68875391
133gamma-aminobutyric acid transport (GO:0015812)2.68733868
134chemosensory behavior (GO:0007635)2.68583161
135cerebellar Purkinje cell differentiation (GO:0021702)2.67790269
136regulation of vesicle fusion (GO:0031338)2.67050085
137ATP hydrolysis coupled proton transport (GO:0015991)2.66744710
138regulation of telomere maintenance (GO:0032204)2.65022926
139regulation of voltage-gated calcium channel activity (GO:1901385)2.64987407
140chromatin assembly (GO:0031497)2.64811864
141heart trabecula morphogenesis (GO:0061384)2.63105096
142negative regulation of DNA biosynthetic process (GO:2000279)2.62517488
143positive regulation of histone H3-K4 methylation (GO:0051571)2.57820723
144positive regulation of meiotic cell cycle (GO:0051446)2.57696292
145female mating behavior (GO:0060180)2.57057259
146social behavior (GO:0035176)2.56582068
147intraspecies interaction between organisms (GO:0051703)2.56582068
148DNA methylation involved in gamete generation (GO:0043046)2.56409853
149establishment of mitochondrion localization (GO:0051654)2.55165277
150mitotic chromosome condensation (GO:0007076)2.54611084
151regulation of cardiac muscle cell apoptotic process (GO:0010665)2.53359675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58907624
2GBX2_23144817_ChIP-Seq_PC3_Human3.41157414
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19773990
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19136588
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17749104
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87482761
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77707038
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77707038
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69523987
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68718458
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.65632403
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64020607
13REST_21632747_ChIP-Seq_MESCs_Mouse2.60236279
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54196553
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51791216
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51389789
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49382187
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47456879
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.44306945
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40923899
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.37403843
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35415451
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.29489117
24DROSHA_22980978_ChIP-Seq_HELA_Human2.24476538
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.23498511
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11940916
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04748472
28* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95442472
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94082503
30AR_21572438_ChIP-Seq_LNCaP_Human1.83418167
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82623888
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66791104
33* ERG_21242973_ChIP-ChIP_JURKAT_Human1.64149161
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62997697
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62850057
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55613502
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53826888
38* RING1B_27294783_Chip-Seq_ESCs_Mouse1.50509691
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48386326
40E2F7_22180533_ChIP-Seq_HELA_Human1.47011661
41IRF1_19129219_ChIP-ChIP_H3396_Human1.46224758
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.43860242
43SMAD4_21799915_ChIP-Seq_A2780_Human1.43060102
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37466558
45ZNF274_21170338_ChIP-Seq_K562_Hela1.36824394
46TAF15_26573619_Chip-Seq_HEK293_Human1.36490526
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36108603
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34428015
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30371526
50* CBX2_27304074_Chip-Seq_ESCs_Mouse1.29807000
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29751247
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29734056
53* RING1B_27294783_Chip-Seq_NPCs_Mouse1.29548017
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29519824
55* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29351638
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27363452
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27154357
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27105011
59IGF1R_20145208_ChIP-Seq_DFB_Human1.27041955
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26491721
61VDR_22108803_ChIP-Seq_LS180_Human1.25742243
62P300_19829295_ChIP-Seq_ESCs_Human1.24247031
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22874380
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.19359448
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18224899
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17796850
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16288620
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15116696
69AR_25329375_ChIP-Seq_VCAP_Human1.14976496
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.14927739
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14893794
72* RNF2_27304074_Chip-Seq_NSC_Mouse1.13728544
73* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13542828
74* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11936805
75* KDM2B_26808549_Chip-Seq_K562_Human1.11752220
76* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11389301
77* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11110408
78AR_19668381_ChIP-Seq_PC3_Human1.10732153
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10725439
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10504936
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10262247
82* ARNT_22903824_ChIP-Seq_MCF-7_Human1.09072014
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08764327
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08414341
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.06997437
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06210947
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04851390
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.03483388
89RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01879467
90SMAD4_21741376_ChIP-Seq_HESCs_Human1.00109140
91AHR_22903824_ChIP-Seq_MCF-7_Human0.99846952
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99153018
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98462669
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97734206
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96494944
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95114931
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94183895
98CTCF_27219007_Chip-Seq_Bcells_Human0.93903160
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.92035003
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90403685
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90306702
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90306702
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89692162
104STAT3_23295773_ChIP-Seq_U87_Human0.89609806
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89594839
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.89521277
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89313323
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89285795
109CBP_20019798_ChIP-Seq_JUKART_Human0.89285795
110RXR_22108803_ChIP-Seq_LS180_Human0.88655770
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87810489
112RUNX2_22187159_ChIP-Seq_PCA_Human0.87767093
113OCT4_19829295_ChIP-Seq_ESCs_Human0.87221335
114* TP53_20018659_ChIP-ChIP_R1E_Mouse0.86487170
115JUN_21703547_ChIP-Seq_K562_Human0.86284184
116OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86159063
117ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85364765
118E2F1_17053090_ChIP-ChIP_MCF-7_Human0.83976136
119TP53_18474530_ChIP-ChIP_U2OS_Human0.83412112
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83254590
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83160589
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83030229
123* TCF4_23295773_ChIP-Seq_U87_Human0.82667154
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.82662319
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81759369
126FOXM1_23109430_ChIP-Seq_U2OS_Human0.80290016
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78720925
128* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77099966
129KLF4_19829295_ChIP-Seq_ESCs_Human0.76237795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.22449369
2MP0003880_abnormal_central_pattern4.12717254
3MP0004270_analgesia3.79540834
4* MP0003635_abnormal_synaptic_transmissio3.75952398
5* MP0002063_abnormal_learning/memory/cond3.23780432
6* MP0009745_abnormal_behavioral_response2.96785689
7* MP0000778_abnormal_nervous_system2.79067679
8MP0000566_synostosis2.78172479
9* MP0002064_seizures2.68235446
10MP0004043_abnormal_pH_regulation2.67249283
11MP0008789_abnormal_olfactory_epithelium2.60653558
12MP0001968_abnormal_touch/_nociception2.57357522
13* MP0002572_abnormal_emotion/affect_behav2.49762966
14MP0002734_abnormal_mechanical_nocicepti2.41164365
15MP0009780_abnormal_chondrocyte_physiolo2.30158026
16MP0010030_abnormal_orbit_morphology2.29280733
17MP0001440_abnormal_grooming_behavior2.26134646
18MP0009046_muscle_twitch2.24094612
19MP0004858_abnormal_nervous_system2.23798688
20MP0002736_abnormal_nociception_after2.22843228
21MP0003718_maternal_effect2.19811012
22MP0005360_urolithiasis2.19213876
23MP0003329_amyloid_beta_deposits2.16826847
24MP0002735_abnormal_chemical_nociception2.10531198
25MP0003890_abnormal_embryonic-extraembry2.09591104
26MP0001486_abnormal_startle_reflex2.08575559
27MP0004885_abnormal_endolymph2.00513547
28MP0008877_abnormal_DNA_methylation2.00436892
29MP0002272_abnormal_nervous_system1.87605684
30MP0001765_abnormal_ion_homeostasis1.85378556
31MP0005423_abnormal_somatic_nervous1.80308879
32MP0002733_abnormal_thermal_nociception1.79319607
33* MP0004811_abnormal_neuron_physiology1.74233417
34MP0003879_abnormal_hair_cell1.73498174
35MP0002067_abnormal_sensory_capabilities1.72614749
36MP0003787_abnormal_imprinting1.70437862
37MP0001970_abnormal_pain_threshold1.61892162
38MP0008961_abnormal_basal_metabolism1.56330678
39* MP0002557_abnormal_social/conspecific_i1.55185582
40MP0004019_abnormal_vitamin_homeostasis1.54899380
41MP0005332_abnormal_amino_acid1.54834538
42MP0002653_abnormal_ependyma_morphology1.54768639
43MP0002184_abnormal_innervation1.54526648
44MP0002163_abnormal_gland_morphology1.44494180
45MP0003121_genomic_imprinting1.40261978
46* MP0002066_abnormal_motor_capabilities/c1.38908870
47MP0000955_abnormal_spinal_cord1.38355145
48MP0006276_abnormal_autonomic_nervous1.38196085
49* MP0002882_abnormal_neuron_morphology1.35023257
50MP0003123_paternal_imprinting1.34969233
51MP0002249_abnormal_larynx_morphology1.34051653
52MP0001905_abnormal_dopamine_level1.32841590
53MP0004133_heterotaxia1.32375030
54MP0000049_abnormal_middle_ear1.29285316
55MP0001293_anophthalmia1.27992523
56MP0001501_abnormal_sleep_pattern1.27190528
57MP0002233_abnormal_nose_morphology1.26451499
58* MP0004924_abnormal_behavior1.24340592
59* MP0005386_behavior/neurological_phenoty1.24340592
60* MP0002152_abnormal_brain_morphology1.23428887
61MP0003283_abnormal_digestive_organ1.21788440
62MP0001984_abnormal_olfaction1.20295527
63MP0003633_abnormal_nervous_system1.19639567
64MP0005551_abnormal_eye_electrophysiolog1.19289233
65MP0005187_abnormal_penis_morphology1.15197098
66MP0005636_abnormal_mineral_homeostasis1.13315068
67MP0000678_abnormal_parathyroid_gland1.10807825
68MP0001756_abnormal_urination1.09572522
69MP0002909_abnormal_adrenal_gland1.09454226
70MP0000751_myopathy1.09241233
71MP0008569_lethality_at_weaning1.09001724
72MP0003195_calcinosis1.08681232
73MP0001346_abnormal_lacrimal_gland1.08514554
74MP0009379_abnormal_foot_pigmentation1.07906188
75MP0002837_dystrophic_cardiac_calcinosis1.07737245
76* MP0002069_abnormal_eating/drinking_beha1.07690883
77MP0005535_abnormal_body_temperature1.06598610
78MP0003693_abnormal_embryo_hatching1.05987843
79MP0002210_abnormal_sex_determination1.05848847
80MP0002876_abnormal_thyroid_physiology1.05375409
81MP0003631_nervous_system_phenotype1.02339447
82MP0004742_abnormal_vestibular_system1.00635595
83MP0005084_abnormal_gallbladder_morpholo0.99882428
84MP0003122_maternal_imprinting0.96094819
85MP0000604_amyloidosis0.93766854
86MP0002234_abnormal_pharynx_morphology0.93335086
87MP0000537_abnormal_urethra_morphology0.92147092
88* MP0000631_abnormal_neuroendocrine_gland0.91047768
89MP0003119_abnormal_digestive_system0.90523328
90MP0000538_abnormal_urinary_bladder0.88878071
91MP0005394_taste/olfaction_phenotype0.88403618
92MP0005499_abnormal_olfactory_system0.88403618
93MP0002102_abnormal_ear_morphology0.88369632
94MP0001929_abnormal_gametogenesis0.88009730
95MP0002822_catalepsy0.87922523
96MP0009643_abnormal_urine_homeostasis0.86801714
97MP0001177_atelectasis0.84428936
98MP0004142_abnormal_muscle_tone0.84186401
99MP0002139_abnormal_hepatobiliary_system0.83947042
100* MP0003861_abnormal_nervous_system0.83423156
101MP0005646_abnormal_pituitary_gland0.82578324
102MP0001502_abnormal_circadian_rhythm0.82049862
103MP0010386_abnormal_urinary_bladder0.80759802
104MP0006292_abnormal_olfactory_placode0.80233082
105* MP0001963_abnormal_hearing_physiology0.79805345
106MP0001664_abnormal_digestion0.79308225
107MP0002138_abnormal_hepatobiliary_system0.79214103
108MP0003755_abnormal_palate_morphology0.78835253
109MP0008872_abnormal_physiological_respon0.77511605
110MP0000428_abnormal_craniofacial_morphol0.77223751
111MP0003938_abnormal_ear_development0.76949967
112MP0008057_abnormal_DNA_replication0.76949422
113MP0005195_abnormal_posterior_eye0.76782414
114MP0000026_abnormal_inner_ear0.75957337
115MP0004484_altered_response_of0.75891868
116MP0008932_abnormal_embryonic_tissue0.75261137
117MP0002089_abnormal_postnatal_growth/wei0.75200501
118MP0002229_neurodegeneration0.75148293
119MP0004233_abnormal_muscle_weight0.75098208
120MP0000653_abnormal_sex_gland0.74997723
121MP0003077_abnormal_cell_cycle0.73152090
122MP0001485_abnormal_pinna_reflex0.72966202
123MP0002752_abnormal_somatic_nervous0.72320732
124MP0002160_abnormal_reproductive_system0.71611827
125MP0002136_abnormal_kidney_physiology0.71564274
126MP0009053_abnormal_anal_canal0.69944123
127* MP0002161_abnormal_fertility/fecundity0.69511040
128* MP0003698_abnormal_male_reproductive0.68525048
129MP0008058_abnormal_DNA_repair0.68124459
130MP0000534_abnormal_ureter_morphology0.68097134
131MP0001145_abnormal_male_reproductive0.66348190
132MP0003075_altered_response_to0.64703459
133MP0003634_abnormal_glial_cell0.64523269
134MP0008874_decreased_physiological_sensi0.64326768
135MP0001529_abnormal_vocalization0.63992122
136MP0000427_abnormal_hair_cycle0.63367297
137MP0003136_yellow_coat_color0.62834479
138MP0000230_abnormal_systemic_arterial0.62628325
139MP0003632_abnormal_nervous_system0.62105964
140* MP0010770_preweaning_lethality0.61686729

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)5.75565275
2Metabolic alkalosis (HP:0200114)4.94731209
3Focal motor seizures (HP:0011153)4.88843255
4Hypokalemic alkalosis (HP:0001949)4.75221035
5Hypomagnesemia (HP:0002917)4.74212552
6Myokymia (HP:0002411)4.67304114
7Abnormality of the aortic arch (HP:0012303)4.62507023
8Gout (HP:0001997)4.42317348
9Hyperactive renin-angiotensin system (HP:0000841)4.39743137
10Polyuria (HP:0000103)4.34745773
11Hyperventilation (HP:0002883)4.22329417
12Focal seizures (HP:0007359)4.20640897
13Epileptic encephalopathy (HP:0200134)4.09029293
14Abnormality of magnesium homeostasis (HP:0004921)4.08839057
15Abnormal urine output (HP:0012590)4.01214837
16Polydipsia (HP:0001959)3.86310061
17Abnormal drinking behavior (HP:0030082)3.86310061
18Abnormality of renal excretion (HP:0011036)3.70727501
19Visual hallucinations (HP:0002367)3.66516049
20Abnormality of chloride homeostasis (HP:0011422)3.61069792
21Abnormality of the labia minora (HP:0012880)3.47022921
22Septo-optic dysplasia (HP:0100842)3.45486871
23Abnormal eating behavior (HP:0100738)3.43646674
24Polyphagia (HP:0002591)3.41781061
25Abnormality of renin-angiotensin system (HP:0000847)3.37584296
26Facial hemangioma (HP:0000329)3.30362613
27Esophageal atresia (HP:0002032)3.25409479
28Broad-based gait (HP:0002136)3.24278635
29Tetany (HP:0001281)3.22522677
30Oligodactyly (HP:0012165)3.09155892
31Poor eye contact (HP:0000817)3.07386924
32Increased purine levels (HP:0004368)3.01710957
33Hyperuricemia (HP:0002149)3.01710957
34Hyperaldosteronism (HP:0000859)3.01452725
35High anterior hairline (HP:0009890)2.97357390
36Alkalosis (HP:0001948)2.82489772
37Ketoacidosis (HP:0001993)2.78423848
38Drooling (HP:0002307)2.78315200
39Excessive salivation (HP:0003781)2.78315200
40Renal salt wasting (HP:0000127)2.77529975
41Abnormal social behavior (HP:0012433)2.76354712
42Impaired social interactions (HP:0000735)2.76354712
43Hypercalciuria (HP:0002150)2.68602062
44Oligodactyly (hands) (HP:0001180)2.66712527
45Atonic seizures (HP:0010819)2.64421904
46Amblyopia (HP:0000646)2.64358169
47Urinary urgency (HP:0000012)2.64286116
48Mutism (HP:0002300)2.61450113
49Absence seizures (HP:0002121)2.58807929
50Ankle clonus (HP:0011448)2.58641841
51Gastrointestinal atresia (HP:0002589)2.56816217
52Generalized tonic-clonic seizures (HP:0002069)2.55902613
53Rib fusion (HP:0000902)2.54550025
54Optic nerve hypoplasia (HP:0000609)2.44061515
55Obstructive sleep apnea (HP:0002870)2.43587455
56Inability to walk (HP:0002540)2.42911667
57Hepatoblastoma (HP:0002884)2.41623339
58Supranuclear gaze palsy (HP:0000605)2.40881936
59Supernumerary spleens (HP:0009799)2.39319002
60Colon cancer (HP:0003003)2.39131789
61Dialeptic seizures (HP:0011146)2.38617241
62Cerebral inclusion bodies (HP:0100314)2.38506096
63Proximal tubulopathy (HP:0000114)2.36343639
64Absent septum pellucidum (HP:0001331)2.35914250
65Hyperglycinuria (HP:0003108)2.35554931
66Epileptiform EEG discharges (HP:0011182)2.32572340
67Abnormality of glycolysis (HP:0004366)2.32249827
68Nephronophthisis (HP:0000090)2.32075137
69Abnormality of cochlea (HP:0000375)2.29068877
70Impaired vibration sensation in the lower limbs (HP:0002166)2.28595900
71Hypokalemia (HP:0002900)2.26884232
72Impulsivity (HP:0100710)2.26476142
73Increased serum pyruvate (HP:0003542)2.25946224
74EEG with generalized epileptiform discharges (HP:0011198)2.22396367
75Febrile seizures (HP:0002373)2.20707689
76Abnormality of purine metabolism (HP:0004352)2.16709614
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16529358
78Hypsarrhythmia (HP:0002521)2.16072847
79Abnormality of midbrain morphology (HP:0002418)2.13758170
80Molar tooth sign on MRI (HP:0002419)2.13758170
81Abnormal lung lobation (HP:0002101)2.11449794
82Fetal akinesia sequence (HP:0001989)2.11226348
83Progressive cerebellar ataxia (HP:0002073)2.10212416
84Athetosis (HP:0002305)2.08320333
85Abnormality of the corticospinal tract (HP:0002492)2.07608395
86Status epilepticus (HP:0002133)2.05765025
87Abnormality of the lower motor neuron (HP:0002366)2.05616619
88Focal dystonia (HP:0004373)2.05591090
89Action tremor (HP:0002345)2.03450147
90Anxiety (HP:0000739)2.02362334
91Sleep apnea (HP:0010535)2.02230333
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.00393134
93Ketosis (HP:0001946)2.00283691
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98602839
95Torticollis (HP:0000473)1.98077466
96Pheochromocytoma (HP:0002666)1.97754812
97Abdominal situs inversus (HP:0003363)1.95654259
98Abnormality of abdominal situs (HP:0011620)1.95654259
99Gait imbalance (HP:0002141)1.94307977
100Hyperphosphaturia (HP:0003109)1.93955134
101Papilledema (HP:0001085)1.93931656
102Abnormality of the metopic suture (HP:0005556)1.93892777
103Chronic hepatic failure (HP:0100626)1.93856161
104Amyotrophic lateral sclerosis (HP:0007354)1.92686309
105Osteomalacia (HP:0002749)1.91424952
106Urinary bladder sphincter dysfunction (HP:0002839)1.89912329
107Abnormality of potassium homeostasis (HP:0011042)1.89863902
108Generalized myoclonic seizures (HP:0002123)1.89641011
109Double outlet right ventricle (HP:0001719)1.89469824
110Congenital malformation of the right heart (HP:0011723)1.89469824
111Tetraplegia (HP:0002445)1.89016520
112Lymphangioma (HP:0100764)1.88878571
113Microglossia (HP:0000171)1.88196072
114Craniofacial dystonia (HP:0012179)1.87337250
115Abnormality of binocular vision (HP:0011514)1.87300141
116Diplopia (HP:0000651)1.87300141
117Abnormality of glycine metabolism (HP:0010895)1.86972033
118Abnormality of serine family amino acid metabolism (HP:0010894)1.86972033
119Neurofibrillary tangles (HP:0002185)1.86458625
120Stereotypic behavior (HP:0000733)1.86369803
121Spastic gait (HP:0002064)1.86152080
122Pachygyria (HP:0001302)1.84290731
123Delayed CNS myelination (HP:0002188)1.83919351
124Ectopic kidney (HP:0000086)1.83672243
125Dysmetria (HP:0001310)1.83061785
126Truncal ataxia (HP:0002078)1.82902352
127Abnormality of the septum pellucidum (HP:0007375)1.82062651
128Insidious onset (HP:0003587)1.81242271
129Termporal pattern (HP:0011008)1.81242271
130Anomalous pulmonary venous return (HP:0010772)1.80450102
131Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79962425
132Nephrocalcinosis (HP:0000121)1.79782658
133Neoplasm of the adrenal cortex (HP:0100641)1.78637393
134Morphological abnormality of the inner ear (HP:0011390)1.78570859
135Abnormality of sodium homeostasis (HP:0010931)1.77815812
136Sclerocornea (HP:0000647)1.77721288
137Lower limb muscle weakness (HP:0007340)1.77485279
138Annular pancreas (HP:0001734)1.76698407
139Megalencephaly (HP:0001355)1.76693991
140Abnormal urine phosphate concentration (HP:0012599)1.75656597
141Partial agenesis of the corpus callosum (HP:0001338)1.75568362
142Abnormality of the renal medulla (HP:0100957)1.73640343
143Preaxial hand polydactyly (HP:0001177)1.73222685
144Renal tubular acidosis (HP:0001947)1.73182168
145Depression (HP:0000716)1.72873374
146Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71261354
147Aplasia/Hypoplasia of the sternum (HP:0006714)1.69175265
148Growth hormone deficiency (HP:0000824)1.68678588
149Pancreatic fibrosis (HP:0100732)1.67304357
150Abnormality of the diencephalon (HP:0010662)1.64929788
151Capillary hemangiomas (HP:0005306)1.64737105
152Maternal diabetes (HP:0009800)1.63833432
153Spinal canal stenosis (HP:0003416)1.62611846
154Male infertility (HP:0003251)1.62001617
155Truncal obesity (HP:0001956)1.59639929
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.58727687
157Hypophosphatemic rickets (HP:0004912)1.57446330
158Cerebral hypomyelination (HP:0006808)1.56285909
159Pancreatic cysts (HP:0001737)1.55879094
160Delayed myelination (HP:0012448)1.55475807
161Hypokinesia (HP:0002375)1.54595808
162Nephrogenic diabetes insipidus (HP:0009806)1.54548783
163True hermaphroditism (HP:0010459)1.53907640
164Genital tract atresia (HP:0001827)1.53406171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK25.69057694
2WNK34.78147206
3MARK14.31786648
4OXSR13.83135478
5EPHA43.69260522
6WNK43.20750457
7NTRK33.07000235
8DAPK22.98810379
9ARAF2.88860579
10MAP3K92.86276621
11TLK12.55990158
12MAP3K42.49452649
13MINK12.28837031
14MAP4K22.28770960
15CDK192.21533542
16PAK62.15396528
17MAP3K122.11734558
18CASK2.11707140
19MAP2K72.10061224
20KSR12.05891340
21DAPK12.00263441
22MAP2K41.89605728
23NTRK21.69945898
24PLK21.60783073
25EPHB21.59872194
26KSR21.59388481
27STK391.57700943
28CDC71.56710705
29BRAF1.55867687
30MAP3K131.49015457
31MAPK131.45045704
32MAP3K51.41580744
33DYRK21.37069717
34CDK51.34084314
35CCNB11.27876867
36LATS21.23319576
37RIPK41.22933707
38PRKD31.22394974
39NUAK11.19995555
40SGK4941.18470018
41SGK2231.18470018
42CAMKK11.13407741
43BRSK11.12969670
44TYRO31.10312119
45AURKA1.07258121
46SIK21.06218381
47TTK1.03503802
48GRK51.02553395
49NTRK11.02411451
50BUB11.01222828
51CDK181.00568895
52MAP3K80.98823285
53CDK150.98624624
54NEK60.96469593
55PHKG20.95486858
56PHKG10.95486858
57PNCK0.94932133
58CDK140.93241626
59PRKCG0.91961975
60UHMK10.88388957
61CDK11A0.85954602
62TRIM280.85918827
63STK380.84976249
64STK110.83961952
65TAOK10.83446776
66CSNK1G20.83022360
67PTK2B0.82145945
68TAF10.80061951
69NEK10.76836976
70PAK30.75939037
71MAPKAPK50.73814801
72PLK30.72341335
73PLK40.71545758
74DYRK1A0.71388543
75PRPF4B0.69628046
76PDK40.68526703
77PDK30.68526703
78FGFR20.65189072
79VRK20.64012616
80PRKCZ0.63134687
81STK240.62647702
82FGR0.61359702
83SGK10.61207696
84CAMK2A0.60738031
85PLK10.60030434
86PRKCI0.59840455
87MAP3K60.58025654
88DAPK30.56293137
89TNIK0.55743407
90MAPK120.54499350
91ERBB30.54128303
92MAP3K20.54058707
93MOS0.53190871
94GRK60.52299087
95ZAK0.51263334
96RET0.50949144
97BMPR20.50335087
98SMG10.49149355
99CAMK2B0.48830501
100RAF10.48682378
101SGK20.47299914
102MAP2K60.46142612
103CAMKK20.45216554
104BCR0.42127562
105CSNK1G30.41726207
106MARK20.41618937
107ATR0.41189425
108MELK0.40392170
109CHEK20.40032275
110VRK10.39439311
111CAMK1G0.39030692
112CSNK1A1L0.38526909
113PDPK10.38246162
114RIPK10.38175402
115NME10.37006693
116PIK3CA0.36755589
117WNK10.36478144
118FYN0.36010992
119DMPK0.35484633
120PDK10.34679363
121CAMK10.33408196
122ROCK20.33146589
123PRKCH0.32897106
124EEF2K0.32853319
125SGK30.32545722
126CAMK1D0.31361038
127FER0.30619931
128FES0.30559538
129CSNK1E0.29746394
130PRKCE0.29070636
131PKN10.29051028
132LIMK10.28347676
133ICK0.27938430
134RPS6KA30.26587819
135CAMK40.25168696
136ADRBK10.24820505
137MAP3K70.23089850
138RPS6KA20.21925546
139SCYL20.21662589
140CSNK1G10.20995915

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16731009
2Synaptic vesicle cycle_Homo sapiens_hsa047213.15575951
3Nicotine addiction_Homo sapiens_hsa050332.93631579
4Collecting duct acid secretion_Homo sapiens_hsa049662.72489462
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.61606040
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.32082400
7Glutamatergic synapse_Homo sapiens_hsa047242.11154012
8Long-term potentiation_Homo sapiens_hsa047202.10416719
9Butanoate metabolism_Homo sapiens_hsa006502.05234388
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04882592
11Circadian entrainment_Homo sapiens_hsa047132.04038341
12GABAergic synapse_Homo sapiens_hsa047271.96484063
13Gastric acid secretion_Homo sapiens_hsa049711.89647035
14Olfactory transduction_Homo sapiens_hsa047401.89240796
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84882092
16Vitamin B6 metabolism_Homo sapiens_hsa007501.82921858
17Morphine addiction_Homo sapiens_hsa050321.82270578
18Basal transcription factors_Homo sapiens_hsa030221.81930989
19Amphetamine addiction_Homo sapiens_hsa050311.77317796
20Salivary secretion_Homo sapiens_hsa049701.69418507
21Dopaminergic synapse_Homo sapiens_hsa047281.68551282
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65316036
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65088210
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.63747974
25Phototransduction_Homo sapiens_hsa047441.62786922
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54812350
27Sulfur relay system_Homo sapiens_hsa041221.54710577
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54190184
29Insulin secretion_Homo sapiens_hsa049111.47191890
30Renin secretion_Homo sapiens_hsa049241.41550526
31Axon guidance_Homo sapiens_hsa043601.41306018
32Cholinergic synapse_Homo sapiens_hsa047251.41292075
33Basal cell carcinoma_Homo sapiens_hsa052171.38075645
34Base excision repair_Homo sapiens_hsa034101.35364843
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34792564
36Fanconi anemia pathway_Homo sapiens_hsa034601.31132520
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30314329
38Cell cycle_Homo sapiens_hsa041101.29266486
39Oxytocin signaling pathway_Homo sapiens_hsa049211.26827613
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26250327
41Cocaine addiction_Homo sapiens_hsa050301.23550856
42Propanoate metabolism_Homo sapiens_hsa006401.22012798
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17812995
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17531791
45Mismatch repair_Homo sapiens_hsa034301.17176907
46Vibrio cholerae infection_Homo sapiens_hsa051101.16720234
47Hedgehog signaling pathway_Homo sapiens_hsa043401.14487449
48Gap junction_Homo sapiens_hsa045401.13968351
49Pyruvate metabolism_Homo sapiens_hsa006201.12645916
50Serotonergic synapse_Homo sapiens_hsa047261.09695927
51Glioma_Homo sapiens_hsa052141.09662062
52Taste transduction_Homo sapiens_hsa047421.09075439
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07667236
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05461722
55Long-term depression_Homo sapiens_hsa047301.04646751
56Bile secretion_Homo sapiens_hsa049761.04270767
57Oxidative phosphorylation_Homo sapiens_hsa001901.03068210
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.02905813
59GnRH signaling pathway_Homo sapiens_hsa049121.02391237
60DNA replication_Homo sapiens_hsa030301.01661048
61Cardiac muscle contraction_Homo sapiens_hsa042601.01206214
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00684782
63Hippo signaling pathway_Homo sapiens_hsa043901.00322935
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96738014
65Homologous recombination_Homo sapiens_hsa034400.96169510
66Calcium signaling pathway_Homo sapiens_hsa040200.95240563
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91811659
68Ovarian steroidogenesis_Homo sapiens_hsa049130.89965364
69ErbB signaling pathway_Homo sapiens_hsa040120.89167874
70Alcoholism_Homo sapiens_hsa050340.88382303
71RNA degradation_Homo sapiens_hsa030180.88239240
72cAMP signaling pathway_Homo sapiens_hsa040240.83807305
73Estrogen signaling pathway_Homo sapiens_hsa049150.82936475
74Steroid biosynthesis_Homo sapiens_hsa001000.81169652
75Arginine and proline metabolism_Homo sapiens_hsa003300.80461101
76Melanogenesis_Homo sapiens_hsa049160.79981878
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79176417
78Alzheimers disease_Homo sapiens_hsa050100.77610802
79Folate biosynthesis_Homo sapiens_hsa007900.76290837
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75235857
81Type II diabetes mellitus_Homo sapiens_hsa049300.74929641
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71009514
83Thyroid hormone synthesis_Homo sapiens_hsa049180.69920025
84Choline metabolism in cancer_Homo sapiens_hsa052310.69210852
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68222853
86Ribosome_Homo sapiens_hsa030100.67761321
87Parkinsons disease_Homo sapiens_hsa050120.65793447
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65303960
89Notch signaling pathway_Homo sapiens_hsa043300.64160083
90mRNA surveillance pathway_Homo sapiens_hsa030150.62959995
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.62762412
92Oocyte meiosis_Homo sapiens_hsa041140.62440024
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62227332
94Carbon metabolism_Homo sapiens_hsa012000.59937879
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58314675
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57487033
97VEGF signaling pathway_Homo sapiens_hsa043700.56601822
98RNA polymerase_Homo sapiens_hsa030200.56413806
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55819707
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54849785
101Nitrogen metabolism_Homo sapiens_hsa009100.52635441
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52518127
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52335975
104Glucagon signaling pathway_Homo sapiens_hsa049220.52063678
105Inositol phosphate metabolism_Homo sapiens_hsa005620.51591464
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51369372
107Fatty acid metabolism_Homo sapiens_hsa012120.51301459
108Dorso-ventral axis formation_Homo sapiens_hsa043200.49907179
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48387920
110Endometrial cancer_Homo sapiens_hsa052130.47287474
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47227654
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.44303477
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43263738
114Mineral absorption_Homo sapiens_hsa049780.43122100
115Peroxisome_Homo sapiens_hsa041460.40412093
116Pancreatic secretion_Homo sapiens_hsa049720.39712440
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39029045
118mTOR signaling pathway_Homo sapiens_hsa041500.38750388
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38077957
120Huntingtons disease_Homo sapiens_hsa050160.38004386
121Ras signaling pathway_Homo sapiens_hsa040140.36786171
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36640336
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36173517
124Fatty acid degradation_Homo sapiens_hsa000710.36014273
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.35004245
126MAPK signaling pathway_Homo sapiens_hsa040100.34956203
127Sulfur metabolism_Homo sapiens_hsa009200.34450803
128Rap1 signaling pathway_Homo sapiens_hsa040150.34288771
129Arginine biosynthesis_Homo sapiens_hsa002200.34256180
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32689660
131Insulin signaling pathway_Homo sapiens_hsa049100.32323349
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30773371
133Wnt signaling pathway_Homo sapiens_hsa043100.30735220
134Tryptophan metabolism_Homo sapiens_hsa003800.29673396

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