EMX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)6.62763234
2behavioral response to nicotine (GO:0035095)6.47197008
3sulfation (GO:0051923)5.15441296
4* cell proliferation in forebrain (GO:0021846)4.78468954
5axonal fasciculation (GO:0007413)4.42483390
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.36771665
7somite development (GO:0061053)4.09664409
8neuron recognition (GO:0008038)4.09115159
9regulation of glomerulus development (GO:0090192)4.04500596
10spinal cord development (GO:0021510)3.98426398
11olfactory bulb development (GO:0021772)3.98205710
12sensory perception of chemical stimulus (GO:0007606)3.97177198
13metanephric tubule development (GO:0072170)3.97092804
14metanephric nephron tubule development (GO:0072234)3.97092804
15negative regulation of systemic arterial blood pressure (GO:0003085)3.94122712
16protein insertion into membrane (GO:0051205)3.89923258
17transmission of nerve impulse (GO:0019226)3.88437688
18cellular response to ATP (GO:0071318)3.86379857
19negative regulation of response to food (GO:0032096)3.78351281
20negative regulation of appetite (GO:0032099)3.78351281
21protein polyglutamylation (GO:0018095)3.78147744
22metanephric mesenchyme development (GO:0072075)3.75646068
23neuron cell-cell adhesion (GO:0007158)3.73839745
24nephron tubule development (GO:0072080)3.72996268
25chondrocyte proliferation (GO:0035988)3.71342592
26otic vesicle formation (GO:0030916)3.70422833
27layer formation in cerebral cortex (GO:0021819)3.69249918
28postsynaptic membrane organization (GO:0001941)3.57844034
29metanephric nephron epithelium development (GO:0072243)3.57671251
30gamma-aminobutyric acid transport (GO:0015812)3.57518293
31regulation of chromatin binding (GO:0035561)3.56308336
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50246267
33regulation of cell proliferation involved in kidney development (GO:1901722)3.44860287
34metanephric epithelium development (GO:0072207)3.41414129
35positive regulation of cAMP-mediated signaling (GO:0043950)3.39355864
36glial cell proliferation (GO:0014009)3.39077053
37renal tubule development (GO:0061326)3.38314214
38sequestering of extracellular ligand from receptor (GO:0035581)3.37682850
39kidney mesenchyme development (GO:0072074)3.37613167
40ovulation cycle (GO:0042698)3.37339207
41positive regulation of gastrulation (GO:2000543)3.36957546
42branching involved in labyrinthine layer morphogenesis (GO:0060670)3.36438075
43dendrite morphogenesis (GO:0048813)3.36120292
44cerebellar Purkinje cell differentiation (GO:0021702)3.33652806
45lateral sprouting from an epithelium (GO:0060601)3.32944015
46lung morphogenesis (GO:0060425)3.30941316
47regulation of female gonad development (GO:2000194)3.28057169
48presynaptic membrane assembly (GO:0097105)3.23637547
49regulation of collateral sprouting (GO:0048670)3.23136568
50gastrulation with mouth forming second (GO:0001702)3.22919672
51positive regulation of fatty acid oxidation (GO:0046321)3.20487726
52planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18309574
53axon extension (GO:0048675)3.17020600
54kidney morphogenesis (GO:0060993)3.10427408
55axon extension involved in axon guidance (GO:0048846)3.08794524
56neuron projection extension involved in neuron projection guidance (GO:1902284)3.08794524
57negative regulation of astrocyte differentiation (GO:0048712)3.06612589
58head development (GO:0060322)3.05937561
59nephron epithelium development (GO:0072009)3.03826755
60negative regulation of axon extension involved in axon guidance (GO:0048843)3.02189211
61purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.01009920
623-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.01009920
63regulation of DNA endoreduplication (GO:0032875)3.00605318
64positive regulation of cardiac muscle cell differentiation (GO:2000727)2.99349972
65regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98614621
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97612159
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.97612159
68NADH dehydrogenase complex assembly (GO:0010257)2.97612159
69limb bud formation (GO:0060174)2.97500016
70regulation of hippo signaling (GO:0035330)2.97450879
71negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94662403
72nephron tubule formation (GO:0072079)2.93426652
73negative chemotaxis (GO:0050919)2.93403064
74regulation of axon extension involved in axon guidance (GO:0048841)2.92739418
75retinal ganglion cell axon guidance (GO:0031290)2.92421997
76presynaptic membrane organization (GO:0097090)2.91987976
77collecting duct development (GO:0072044)2.91715714
78negative regulation of axon guidance (GO:1902668)2.91340292
79dendritic spine morphogenesis (GO:0060997)2.90837895
80G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.90230599
81protein localization to cilium (GO:0061512)2.90198952
82central nervous system projection neuron axonogenesis (GO:0021952)2.89419049
83proximal/distal pattern formation (GO:0009954)2.88375757
84specification of organ identity (GO:0010092)2.88197369
85pyrimidine nucleobase catabolic process (GO:0006208)2.87736355
86membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87497243
87regulation of axon guidance (GO:1902667)2.86831269
88water-soluble vitamin biosynthetic process (GO:0042364)2.86512096
89cranial nerve structural organization (GO:0021604)2.85686016
90cellular anion homeostasis (GO:0030002)2.84432867
91DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.84184597
92facial nerve structural organization (GO:0021612)2.83637381
93neuron projection extension (GO:1990138)2.83455767
94urogenital system development (GO:0001655)2.83432424
95cranial nerve morphogenesis (GO:0021602)2.83394674
96embryonic body morphogenesis (GO:0010172)2.82951058
97cerebral cortex neuron differentiation (GO:0021895)2.82374280
98lung-associated mesenchyme development (GO:0060484)2.78479056
99auditory receptor cell differentiation (GO:0042491)2.77964472
100cell migration in hindbrain (GO:0021535)2.76141357
101regulation of female receptivity (GO:0045924)2.76108070
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.75400490
103intraciliary transport (GO:0042073)2.75080157
104parturition (GO:0007567)2.73474665
105outer ear morphogenesis (GO:0042473)2.72328625
106notochord development (GO:0030903)2.72158472
107flavonoid metabolic process (GO:0009812)2.72100459
108tooth mineralization (GO:0034505)2.71412526
109positive regulation of synapse maturation (GO:0090129)2.71149526
110cochlea morphogenesis (GO:0090103)2.69284035
111negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.69014681
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68890389
113cerebral cortex radially oriented cell migration (GO:0021799)2.68690842
114positive regulation of metanephros development (GO:0072216)2.66669789
115neuromuscular synaptic transmission (GO:0007274)2.66625574
116regulation of mesenchymal cell apoptotic process (GO:2001053)2.66200657
117mesonephros development (GO:0001823)2.65648593
118negative regulation of catenin import into nucleus (GO:0035414)2.65557005
119glomerulus development (GO:0032835)2.64303673
120kynurenine metabolic process (GO:0070189)2.63690940
121embryonic hindlimb morphogenesis (GO:0035116)2.63464183
122central nervous system neuron development (GO:0021954)2.63432108
123pituitary gland development (GO:0021983)2.63281566
124positive regulation of potassium ion transmembrane transport (GO:1901381)2.63206112
125regulation of phospholipid biosynthetic process (GO:0071071)2.62739212
126anatomical structure arrangement (GO:0048532)2.62214518
127hippocampus development (GO:0021766)2.61878928
128pharyngeal system development (GO:0060037)2.61372781
129multicellular organismal signaling (GO:0035637)2.61116906
130mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.60941761
131ganglion development (GO:0061548)2.60750550
132nonmotile primary cilium assembly (GO:0035058)2.60404784
133regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60030925
134membrane depolarization during action potential (GO:0086010)2.59489467
135epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.59005310
136negative regulation of transcription regulatory region DNA binding (GO:2000678)2.58581550
137negative regulation of telomere maintenance (GO:0032205)2.58428485
138membrane repolarization during action potential (GO:0086011)2.57915853
139protein localization to synapse (GO:0035418)2.57704300
140regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.57294831
141ephrin receptor signaling pathway (GO:0048013)2.57073177
142forebrain neuron development (GO:0021884)2.56014293
143dorsal/ventral pattern formation (GO:0009953)2.55833583
144forebrain neuron differentiation (GO:0021879)2.55749471
145regulation of sequestering of triglyceride (GO:0010889)2.55289111
146adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.55111376
147regulation of action potential (GO:0098900)2.55083658
148negative regulation of microtubule polymerization (GO:0031115)2.54800869
149synaptic vesicle docking involved in exocytosis (GO:0016081)2.54759474
150indole-containing compound catabolic process (GO:0042436)2.54439036
151indolalkylamine catabolic process (GO:0046218)2.54439036
152tryptophan catabolic process (GO:0006569)2.54439036
153detection of light stimulus involved in sensory perception (GO:0050962)2.54405342
154detection of light stimulus involved in visual perception (GO:0050908)2.54405342
155motor neuron axon guidance (GO:0008045)2.54257597
156gonadal mesoderm development (GO:0007506)2.53262392
157cell differentiation in hindbrain (GO:0021533)2.53029205
158limb development (GO:0060173)2.52979100
159appendage development (GO:0048736)2.52979100
160negative regulation of embryonic development (GO:0045992)2.52482332
161regulation of telomerase activity (GO:0051972)2.51954189
162left/right axis specification (GO:0070986)2.51135837
163cell differentiation in spinal cord (GO:0021515)2.50458095
164regulation of transcription regulatory region DNA binding (GO:2000677)2.50341861
165positive regulation of glomerulus development (GO:0090193)2.50251272
166endoderm formation (GO:0001706)2.50120353
167negative regulation of cardiac muscle tissue development (GO:0055026)2.49201180
168spinal cord association neuron differentiation (GO:0021527)2.49034290
169DNA damage response, signal transduction resulting in transcription (GO:0042772)2.48462175
170regulation of synapse maturation (GO:0090128)2.46922956
171central nervous system neuron axonogenesis (GO:0021955)2.46831663
172regulation of response to food (GO:0032095)2.46406867
173hippo signaling (GO:0035329)2.44558678
174embryonic forelimb morphogenesis (GO:0035115)2.44533831
175body morphogenesis (GO:0010171)2.44489312
176negative regulation of anoikis (GO:2000811)2.41665650
177neuroblast proliferation (GO:0007405)2.40963354
178dermatan sulfate biosynthetic process (GO:0030208)2.39765419
179negative regulation of oligodendrocyte differentiation (GO:0048715)2.39632021
180locomotory exploration behavior (GO:0035641)2.39485013
181negative regulation of axon extension (GO:0030517)2.39095680
182aminoglycoside antibiotic metabolic process (GO:0030647)2.37231688
183forelimb morphogenesis (GO:0035136)2.36232517
184vocalization behavior (GO:0071625)2.35873383
185atrial cardiac muscle cell action potential (GO:0086014)2.35540958
186negative regulation of smoothened signaling pathway (GO:0045879)2.34927475
187morphogenesis of an epithelial sheet (GO:0002011)2.34629893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70206210
2* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.02103379
3* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.02103379
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98592324
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.93108492
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.76909017
7* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61335897
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59939574
9GBX2_23144817_ChIP-Seq_PC3_Human2.58709352
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55379789
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54819022
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53928373
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35292263
14* RNF2_27304074_Chip-Seq_ESCs_Mouse2.29491005
15PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.27338975
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.18293962
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.17931935
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.14280057
19* CBX2_27304074_Chip-Seq_ESCs_Mouse2.13666544
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13031776
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08019844
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05217896
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94816405
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92771859
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86430739
26* RING1B_27294783_Chip-Seq_ESCs_Mouse1.84776434
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78836701
28* RING1B_27294783_Chip-Seq_NPCs_Mouse1.77931230
29* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72172124
30RNF2_27304074_Chip-Seq_NSC_Mouse1.71036171
31* TP53_20018659_ChIP-ChIP_R1E_Mouse1.69949772
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65875933
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65235834
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63235957
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.63121558
36* DROSHA_22980978_ChIP-Seq_HELA_Human1.62324119
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60194025
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52685402
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49497405
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.44963598
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44028028
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42991269
43* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41251305
44TP53_18474530_ChIP-ChIP_U2OS_Human1.41236001
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.38720592
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37840720
47VDR_22108803_ChIP-Seq_LS180_Human1.37519825
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37016309
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35443313
50AHR_22903824_ChIP-Seq_MCF-7_Human1.33396960
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32606514
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.31592814
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.30614986
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28161012
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.26578205
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25767600
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.25579458
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24615388
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.24146510
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21481738
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20577472
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19673358
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19673358
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19667481
65IRF1_19129219_ChIP-ChIP_H3396_Human1.19412537
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.19178211
67KDM2B_26808549_Chip-Seq_K562_Human1.17733356
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17141726
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16474493
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16411383
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16331893
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15666959
73* SMAD4_21799915_ChIP-Seq_A2780_Human1.15567555
74P300_19829295_ChIP-Seq_ESCs_Human1.15384347
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14669668
76EWS_26573619_Chip-Seq_HEK293_Human1.13511812
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.13083994
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09023219
79REST_21632747_ChIP-Seq_MESCs_Mouse1.08718618
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08630284
81* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07571203
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07277793
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06796853
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06513123
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06466252
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06195944
87TP53_16413492_ChIP-PET_HCT116_Human1.05604710
88ZNF274_21170338_ChIP-Seq_K562_Hela1.03815388
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03631531
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01899260
91STAT3_23295773_ChIP-Seq_U87_Human1.01207099
92IGF1R_20145208_ChIP-Seq_DFB_Human1.01012015
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00659311
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99891732
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99749165
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99015159
97* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98998423
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97776303
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97333119
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97248572
101* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96404588
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96289535
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95616304
104TAF15_26573619_Chip-Seq_HEK293_Human0.95407343
105BCAT_22108803_ChIP-Seq_LS180_Human0.95334016
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95005711
107FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94894772
108RARB_27405468_Chip-Seq_BRAIN_Mouse0.94346571
109AR_21572438_ChIP-Seq_LNCaP_Human0.94026519
110AR_19668381_ChIP-Seq_PC3_Human0.93960654
111* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93920378
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93433180
113* TCF4_23295773_ChIP-Seq_U87_Human0.93375079
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93373859
115* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92282527
116AR_25329375_ChIP-Seq_VCAP_Human0.91312326
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91276560
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90747383
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.89652812
120FUS_26573619_Chip-Seq_HEK293_Human0.89603800
121* RUNX2_22187159_ChIP-Seq_PCA_Human0.89534806
122MYC_18940864_ChIP-ChIP_HL60_Human0.89326955
123* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88987272
124SOX2_21211035_ChIP-Seq_LN229_Gbm0.88446351
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87894262
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87363509
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87326964
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87089214
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86947845
130ER_23166858_ChIP-Seq_MCF-7_Human0.85455289
131CBP_20019798_ChIP-Seq_JUKART_Human0.85137406
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85137406
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.84897819
134RXR_22108803_ChIP-Seq_LS180_Human0.84577139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.18090091
2MP0008789_abnormal_olfactory_epithelium4.07237225
3MP0005499_abnormal_olfactory_system3.47502853
4MP0005394_taste/olfaction_phenotype3.47502853
5MP0010030_abnormal_orbit_morphology2.78232829
6* MP0000778_abnormal_nervous_system2.52162134
7MP0003880_abnormal_central_pattern2.34467332
8MP0005377_hearing/vestibular/ear_phenot2.27363654
9MP0003878_abnormal_ear_physiology2.27363654
10MP0002653_abnormal_ependyma_morphology2.24821837
11MP0004859_abnormal_synaptic_plasticity2.10252174
12MP0005623_abnormal_meninges_morphology2.08698037
13MP0002233_abnormal_nose_morphology2.08592251
14MP0000537_abnormal_urethra_morphology2.04842619
15MP0003787_abnormal_imprinting2.02587020
16MP0004145_abnormal_muscle_electrophysio2.00347909
17MP0004130_abnormal_muscle_cell1.98501454
18MP0008438_abnormal_cutaneous_collagen1.98019030
19MP0003646_muscle_fatigue1.96757732
20* MP0000049_abnormal_middle_ear1.96056639
21MP0000534_abnormal_ureter_morphology1.95923424
22MP0003942_abnormal_urinary_system1.95771431
23MP0009250_abnormal_appendicular_skeleto1.95004216
24MP0009379_abnormal_foot_pigmentation1.86511366
25MP0001440_abnormal_grooming_behavior1.84010673
26MP0009053_abnormal_anal_canal1.81476703
27MP0002249_abnormal_larynx_morphology1.80741834
28MP0002163_abnormal_gland_morphology1.75462729
29MP0004134_abnormal_chest_morphology1.74005612
30MP0002184_abnormal_innervation1.73068821
31* MP0002272_abnormal_nervous_system1.72708492
32MP0009745_abnormal_behavioral_response1.68528465
33MP0003385_abnormal_body_wall1.66160189
34MP0001958_emphysema1.63338653
35MP0005551_abnormal_eye_electrophysiolog1.55526169
36MP0004142_abnormal_muscle_tone1.54448707
37MP0005670_abnormal_white_adipose1.54318030
38MP0001968_abnormal_touch/_nociception1.54161305
39MP0003938_abnormal_ear_development1.52903927
40MP0000566_synostosis1.50635412
41MP0002733_abnormal_thermal_nociception1.50079532
42MP0003879_abnormal_hair_cell1.49489629
43MP0005423_abnormal_somatic_nervous1.46051295
44MP0002064_seizures1.43827393
45MP0006072_abnormal_retinal_apoptosis1.43442707
46MP0005389_reproductive_system_phenotype1.42990756
47MP0008872_abnormal_physiological_respon1.42167397
48MP0002735_abnormal_chemical_nociception1.41044946
49MP0003755_abnormal_palate_morphology1.40004240
50MP0002932_abnormal_joint_morphology1.39415357
51MP0008877_abnormal_DNA_methylation1.38942924
52MP0001970_abnormal_pain_threshold1.38808624
53MP0002282_abnormal_trachea_morphology1.37709322
54* MP0001485_abnormal_pinna_reflex1.37170566
55MP0003123_paternal_imprinting1.37129462
56* MP0000026_abnormal_inner_ear1.37116588
57MP0003941_abnormal_skin_development1.37092901
58MP0003937_abnormal_limbs/digits/tail_de1.36888059
59MP0002138_abnormal_hepatobiliary_system1.36863157
60* MP0003861_abnormal_nervous_system1.35431664
61MP0002876_abnormal_thyroid_physiology1.34670943
62MP0004885_abnormal_endolymph1.33613481
63MP0005503_abnormal_tendon_morphology1.33262706
64MP0002896_abnormal_bone_mineralization1.31998333
65MP0003890_abnormal_embryonic-extraembry1.28658907
66* MP0002116_abnormal_craniofacial_bone1.26969922
67MP0005248_abnormal_Harderian_gland1.26751101
68MP0003121_genomic_imprinting1.24705632
69MP0004270_analgesia1.24654939
70MP0009046_muscle_twitch1.23077358
71MP0003122_maternal_imprinting1.22610117
72MP0003283_abnormal_digestive_organ1.22149872
73MP0004858_abnormal_nervous_system1.21998903
74MP0002557_abnormal_social/conspecific_i1.21817139
75MP0002928_abnormal_bile_duct1.21338074
76MP0005187_abnormal_penis_morphology1.21179527
77MP0005257_abnormal_intraocular_pressure1.20986204
78MP0000538_abnormal_urinary_bladder1.20861103
79* MP0002752_abnormal_somatic_nervous1.16613712
80MP0002102_abnormal_ear_morphology1.16028715
81MP0001293_anophthalmia1.13915891
82* MP0000631_abnormal_neuroendocrine_gland1.13742985
83MP0003315_abnormal_perineum_morphology1.13057030
84* MP0005195_abnormal_posterior_eye1.12623494
85MP0005508_abnormal_skeleton_morphology1.12429397
86MP0005646_abnormal_pituitary_gland1.12286779
87* MP0002152_abnormal_brain_morphology1.11907568
88MP0002638_abnormal_pupillary_reflex1.11737696
89MP0000678_abnormal_parathyroid_gland1.10874856
90MP0000428_abnormal_craniofacial_morphol1.10304077
91MP0002063_abnormal_learning/memory/cond1.10251418
92MP0001299_abnormal_eye_distance/1.09499682
93MP0002160_abnormal_reproductive_system1.09469377
94MP0005367_renal/urinary_system_phenotyp1.08486991
95MP0000516_abnormal_urinary_system1.08486991
96MP0003635_abnormal_synaptic_transmissio1.07796068
97MP0002734_abnormal_mechanical_nocicepti1.07762025
98* MP0002882_abnormal_neuron_morphology1.06760271
99MP0006276_abnormal_autonomic_nervous1.05283961
100MP0002089_abnormal_postnatal_growth/wei1.05270467
101MP0004742_abnormal_vestibular_system1.04522931
102MP0001286_abnormal_eye_development1.04291679
103MP0002254_reproductive_system_inflammat1.03620814
104MP0005645_abnormal_hypothalamus_physiol1.02354552
105MP0001502_abnormal_circadian_rhythm1.02242983
106MP0002067_abnormal_sensory_capabilities1.00283664
107MP0003115_abnormal_respiratory_system0.99797151
108MP0002837_dystrophic_cardiac_calcinosis0.99037384
109MP0001486_abnormal_startle_reflex0.98661990
110MP0009384_cardiac_valve_regurgitation0.98617060
111MP0002092_abnormal_eye_morphology0.96720168
112MP0002115_abnormal_skeleton_extremities0.96500419
113MP0003935_abnormal_craniofacial_develop0.96127867
114MP0000163_abnormal_cartilage_morphology0.94523246
115MP0003119_abnormal_digestive_system0.92985367
116MP0003195_calcinosis0.92875611
117MP0002234_abnormal_pharynx_morphology0.91614275
118MP0000432_abnormal_head_morphology0.91192976
119MP0000762_abnormal_tongue_morphology0.90353311
120MP0002736_abnormal_nociception_after0.90343300
121MP0001346_abnormal_lacrimal_gland0.90177474
122MP0004272_abnormal_basement_membrane0.89991727
123MP0001905_abnormal_dopamine_level0.88712083
124MP0002177_abnormal_outer_ear0.88645070
125MP0002109_abnormal_limb_morphology0.86997671
126MP0005253_abnormal_eye_physiology0.86708726
127MP0005084_abnormal_gallbladder_morpholo0.86465206
128MP0002697_abnormal_eye_size0.86440972
129MP0002114_abnormal_axial_skeleton0.85463372
130MP0005275_abnormal_skin_tensile0.85284262
131MP0006292_abnormal_olfactory_placode0.85263307
132MP0009780_abnormal_chondrocyte_physiolo0.84395595
133MP0004133_heterotaxia0.84183614
134* MP0002081_perinatal_lethality0.84059060
135MP0002751_abnormal_autonomic_nervous0.83522828
136MP0005379_endocrine/exocrine_gland_phen0.83520452
137MP0002938_white_spotting0.82942217
138MP0001177_atelectasis0.81492806
139* MP0001963_abnormal_hearing_physiology0.80320291
140MP0002111_abnormal_tail_morphology0.79475740
141MP0002572_abnormal_emotion/affect_behav0.78938819
142MP0001340_abnormal_eyelid_morphology0.76843631
143MP0000955_abnormal_spinal_cord0.75803962

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.58285843
2Progressive cerebellar ataxia (HP:0002073)3.82674191
3Pendular nystagmus (HP:0012043)3.79101605
4True hermaphroditism (HP:0010459)3.74562088
5Pancreatic fibrosis (HP:0100732)3.74335431
6Pancreatic cysts (HP:0001737)3.66261028
7Abnormality of dentin (HP:0010299)3.66191756
8Premature rupture of membranes (HP:0001788)3.39739182
9Short 1st metacarpal (HP:0010034)3.33457988
10Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.33457988
11Morphological abnormality of the middle ear (HP:0008609)3.26313571
12Agitation (HP:0000713)3.22025537
13Stenosis of the external auditory canal (HP:0000402)3.06827539
14Shallow orbits (HP:0000586)2.95343434
15Increased circulating renin level (HP:0000848)2.93175975
16Abnormality of the 1st metacarpal (HP:0010009)2.90490290
17Abolished electroretinogram (ERG) (HP:0000550)2.90029917
18Metabolic alkalosis (HP:0200114)2.82500142
19Abnormality of the proximal phalanges of the hand (HP:0009834)2.81152420
20Asplenia (HP:0001746)2.78308436
21Neonatal short-limb short stature (HP:0008921)2.76997036
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76542907
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.72573735
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.72013033
25Abnormality of DNA repair (HP:0003254)2.70523402
26Abnormality of the nasal septum (HP:0000419)2.69497478
27Cystic liver disease (HP:0006706)2.66990521
28Bell-shaped thorax (HP:0001591)2.66281328
29Septo-optic dysplasia (HP:0100842)2.63262692
30Short 4th metacarpal (HP:0010044)2.62848981
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62848981
32Aplasia of the phalanges of the hand (HP:0009802)2.58000276
33Aplasia involving bones of the extremities (HP:0009825)2.58000276
34Aplasia involving bones of the upper limbs (HP:0009823)2.58000276
35Increased corneal curvature (HP:0100692)2.56852538
36Keratoconus (HP:0000563)2.56852538
37Severe visual impairment (HP:0001141)2.55372838
38Type II lissencephaly (HP:0007260)2.54041911
39Ectopic kidney (HP:0000086)2.53544470
40Gait imbalance (HP:0002141)2.53314833
41Short phalanx of the thumb (HP:0009660)2.52006798
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.50303136
43Protrusio acetabuli (HP:0003179)2.48279438
44Medial flaring of the eyebrow (HP:0010747)2.48157973
45Short nail (HP:0001799)2.46247514
46Short femoral neck (HP:0100864)2.43074300
47Anomalous pulmonary venous return (HP:0010772)2.41119377
48Bicornuate uterus (HP:0000813)2.40007883
49Aortic dissection (HP:0002647)2.37380246
50Short hallux (HP:0010109)2.36721798
51Synostosis of carpal bones (HP:0005048)2.36642327
52Confusion (HP:0001289)2.36142039
53Absent thumb (HP:0009777)2.34150753
54Absent/shortened dynein arms (HP:0200106)2.33047537
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.33047537
56Sclerocornea (HP:0000647)2.31627605
57Decreased central vision (HP:0007663)2.30849295
58Anencephaly (HP:0002323)2.29125707
59Renal hypoplasia (HP:0000089)2.28529568
60Nephrogenic diabetes insipidus (HP:0009806)2.25357839
61Bifid tongue (HP:0010297)2.25163002
62Abnormality of the phalanges of the 2nd finger (HP:0009541)2.23788980
63Aplasia/Hypoplasia of the hallux (HP:0008362)2.23755743
64Congenital primary aphakia (HP:0007707)2.22778744
65Hypoplasia of the ulna (HP:0003022)2.22294020
66Congenital stationary night blindness (HP:0007642)2.21743402
67Abnormal rod and cone electroretinograms (HP:0008323)2.21385636
68Vaginal atresia (HP:0000148)2.19958761
69Bony spicule pigmentary retinopathy (HP:0007737)2.19132602
70Furrowed tongue (HP:0000221)2.18411413
71Genital tract atresia (HP:0001827)2.17598092
72Cutaneous finger syndactyly (HP:0010554)2.16575792
73Tubular atrophy (HP:0000092)2.15387076
74Megalencephaly (HP:0001355)2.14027743
75Anosmia (HP:0000458)2.14026428
76Synostosis involving the elbow (HP:0003938)2.12508779
77Humeroradial synostosis (HP:0003041)2.12508779
78Abnormality of the pulmonary veins (HP:0011718)2.08917495
79Chronic hepatic failure (HP:0100626)2.08077574
80Diplopia (HP:0000651)2.07916703
81Abnormality of binocular vision (HP:0011514)2.07916703
82Abnormal respiratory motile cilium physiology (HP:0012261)2.06724107
83Polyuria (HP:0000103)2.06375909
84Abnormal number of incisors (HP:0011064)2.05673589
85Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.04485352
86Abnormality of molar morphology (HP:0011070)2.02631737
87Abnormality of molar (HP:0011077)2.02631737
88Aplasia/Hypoplasia of the tongue (HP:0010295)2.02555331
89Postaxial hand polydactyly (HP:0001162)2.02027042
90Coronal craniosynostosis (HP:0004440)2.00967681
91Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.00506986
92Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00299472
93Fibular aplasia (HP:0002990)1.98447533
94Hyperactive renin-angiotensin system (HP:0000841)1.98331989
95Myokymia (HP:0002411)1.98315168
96Omphalocele (HP:0001539)1.98007692
97Congenital sensorineural hearing impairment (HP:0008527)1.97865095
98Abnormality of midbrain morphology (HP:0002418)1.97505780
99Molar tooth sign on MRI (HP:0002419)1.97505780
100Postaxial foot polydactyly (HP:0001830)1.97295463
101Action tremor (HP:0002345)1.97068934
102Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96445224
103Visual hallucinations (HP:0002367)1.96357644
104Arterial tortuosity (HP:0005116)1.96282865
105Hypokalemic alkalosis (HP:0001949)1.95919753
106Abnormality of the phalanges of the 5th finger (HP:0004213)1.95851300
107Abnormality of the renal medulla (HP:0100957)1.95023238
108Natal tooth (HP:0000695)1.93996790
109Abnormality of the renal collecting system (HP:0004742)1.93981117
110Retinal dysplasia (HP:0007973)1.92146581
111Reticulocytopenia (HP:0001896)1.91982571
112Aplasia/Hypoplasia of the lens (HP:0008063)1.91884319
113Abnormality of the 4th metacarpal (HP:0010012)1.90396657
114Male pseudohermaphroditism (HP:0000037)1.89075186
115Hemiplegia (HP:0002301)1.88838086
116Cerebellar dysplasia (HP:0007033)1.88352666
117Cutaneous syndactyly (HP:0012725)1.88110850
118Hypomagnesemia (HP:0002917)1.87249657
119Soft skin (HP:0000977)1.86822880
120Vascular tortuosity (HP:0004948)1.86622062
121Carpal bone hypoplasia (HP:0001498)1.86036782
122Anterior segment dysgenesis (HP:0007700)1.86027535
123Abnormality of cochlea (HP:0000375)1.85767867
124Choanal stenosis (HP:0000452)1.85212239
125Methylmalonic acidemia (HP:0002912)1.84895508
126Congenital hepatic fibrosis (HP:0002612)1.84596430
127Rib fusion (HP:0000902)1.83678567
128Abnormal urine output (HP:0012590)1.83197708
129Pelvic girdle muscle weakness (HP:0003749)1.82294582
130Wrist flexion contracture (HP:0001239)1.82243964
131Abnormal respiratory epithelium morphology (HP:0012253)1.82118724
132Abnormal respiratory motile cilium morphology (HP:0005938)1.82118724
133Taurodontia (HP:0000679)1.81956117
134Abnormality of permanent molar morphology (HP:0011071)1.81956117
135Abnormality of the dental root (HP:0006486)1.81956117
136Hyperaldosteronism (HP:0000859)1.80917176
137Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.80338911
138Abnormality of the middle phalanges of the toes (HP:0010183)1.79855281
139Abnormality of renal excretion (HP:0011036)1.79733464
140Focal seizures (HP:0007359)1.79370634
141Symphalangism affecting the phalanges of the hand (HP:0009773)1.78566991
142Broad metatarsal (HP:0001783)1.77397172
143Small hand (HP:0200055)1.77262576
144Fibular hypoplasia (HP:0003038)1.76889160
145Hydroureter (HP:0000072)1.76392406
146Advanced eruption of teeth (HP:0006288)1.75795956
147Diastasis recti (HP:0001540)1.75716274
148Nephronophthisis (HP:0000090)1.75268307
149Hepatoblastoma (HP:0002884)1.74962863
150Aplasia/Hypoplasia of the patella (HP:0006498)1.74859363
151Gaze-evoked nystagmus (HP:0000640)1.74858951
152Adrenal hypoplasia (HP:0000835)1.74386393
153Broad ribs (HP:0000885)1.73913848
154Truncal obesity (HP:0001956)1.73886967
155Abnormality of the pubic bones (HP:0003172)1.73773136
156Abnormality of renin-angiotensin system (HP:0000847)1.73596583
157Buphthalmos (HP:0000557)1.71678284
158Abnormality of macular pigmentation (HP:0008002)1.71221578
159Turricephaly (HP:0000262)1.71105394
160Abnormal drinking behavior (HP:0030082)1.70385529
161Polydipsia (HP:0001959)1.70385529
162Shawl scrotum (HP:0000049)1.69843671
163Aortic aneurysm (HP:0004942)1.69293815
164Intellectual disability, moderate (HP:0002342)1.68883624
165Chorioretinal atrophy (HP:0000533)1.68237795
166Abnormality of the dental pulp (HP:0006479)1.66820234
167Complete atrioventricular canal defect (HP:0001674)1.65870431
168Abnormality of chloride homeostasis (HP:0011422)1.64576316
169Broad distal phalanx of finger (HP:0009836)1.64467639
170Midline defect of the nose (HP:0004122)1.64444279
171Lymphangioma (HP:0100764)1.64279670
172Abnormality of the phalanges of the hallux (HP:0010057)1.64260657
173Stage 5 chronic kidney disease (HP:0003774)1.62800287
174Mixed hearing impairment (HP:0000410)1.62749825
175Abnormality of the musculature of the pelvis (HP:0001469)1.61286517
176Abnormality of the hip-girdle musculature (HP:0001445)1.61286517
177Abnormality of the antihelix (HP:0009738)1.60978954
178Abnormality of magnesium homeostasis (HP:0004921)1.60396282
179Atrioventricular canal defect (HP:0006695)1.60357619
180Bronchomalacia (HP:0002780)1.59058774
181Down-sloping shoulders (HP:0200021)1.57141933
182Microglossia (HP:0000171)1.56559209
183Supranuclear gaze palsy (HP:0000605)1.56315121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB33.63018753
2GRK13.29210157
3DDR23.20368233
4ADRBK23.08319824
5EPHB22.96497106
6FRK2.82524127
7MARK12.80355123
8SIK22.64386692
9EPHA42.50856599
10PHKG12.43863656
11PHKG22.43863656
12PINK12.29778096
13WNK32.27728616
14NTRK22.20596933
15MAPK132.13915294
16STK38L2.09575970
17TRIB32.05985987
18PAK32.02801944
19WNK42.01505691
20TLK11.97239766
21PLK21.95458907
22LATS21.82522980
23STK161.77118229
24NUAK11.70683073
25PRKD31.59275867
26OXSR11.54530936
27TAF11.52814663
28BMPR1B1.46202632
29CASK1.45676054
30DYRK1B1.45422620
31KSR11.43696569
32LMTK21.43502899
33PNCK1.42981266
34LATS11.39451835
35ZAK1.38022573
36MINK11.36036111
37DYRK21.35789657
38STK381.32212326
39CDK191.30444144
40MAP3K91.28354692
41MAP4K21.26240013
42SRPK11.25643518
43GRK71.21190575
44DYRK31.18339724
45SGK2231.16344174
46SGK4941.16344174
47TNIK1.13221945
48MKNK11.12637983
49PASK1.12590954
50PAK61.11072594
51DYRK1A1.10280924
52TYRO31.09164245
53INSRR1.08990794
54CDC71.08138367
55STK111.06350557
56PRKCH1.05819021
57EPHA31.05100525
58AKT31.03260545
59NTRK31.02799319
60CAMK1G1.01427895
61PDGFRA1.00537731
62SIK10.99195968
63TIE10.99023990
64CDK90.98378092
65CSNK1A1L0.97410967
66GRK50.95591879
67DAPK20.95491129
68NEK10.95391724
69WNK10.95244538
70FER0.94367498
71CAMK2B0.94364880
72BMPR20.93788948
73RPS6KA60.92842431
74CAMK10.92424680
75PKN10.91313227
76ADRBK10.91185940
77TTN0.90823446
78PTK2B0.90347406
79MAP3K40.89837537
80CSNK1G10.89668434
81AURKA0.88336624
82TAOK30.87871456
83STK390.82630302
84ROCK10.82404332
85ICK0.82154041
86ERBB20.81562824
87SGK20.80794701
88CAMKK10.80752968
89MAP2K70.80028141
90ROCK20.79953772
91NEK20.79532012
92PIK3CA0.76594718
93MKNK20.76132967
94CAMK40.75917004
95CAMKK20.74895624
96CSNK1G20.72484033
97PRKAA10.71113264
98PRKCG0.70622072
99PRKACA0.70510355
100MARK20.70489901
101RPS6KL10.69156384
102RPS6KC10.69156384
103CSNK1A10.68270834
104CAMK1D0.67992156
105FGR0.66923930
106ABL20.66692264
107PRKCE0.65392620
108CSNK1G30.64850687
109CDK50.64192660
110PRKCZ0.63472391
111UHMK10.61624028
112SGK10.59186057
113RIPK10.59170184
114PAK20.58706423
115PRKD20.58035242
116MAPK150.56668293
117MAPKAPK50.54888059
118FGFR10.54513301
119NTRK10.54420021
120FGFR20.54396689
121SGK30.52710232
122MAP2K40.52656749
123CDK140.50732545
124MAP3K100.50248936
125VRK10.50202717
126LIMK10.50159715
127RPS6KA50.49250537
128ILK0.49092414
129EIF2AK20.48941177
130CAMK2D0.48676713
131EEF2K0.47079955
132DAPK30.46876440
133MARK30.46505093
134RPS6KA20.45999963
135CAMK2A0.44814953
136ACVR1B0.44011815
137CDK180.42434617
138PTK20.41297443
139CDK150.41211971
140CDC42BPA0.41068962
141CAMK2G0.40973171
142PLK40.40479709
143PRKCI0.39170656
144DMPK0.37571312
145PAK40.36190569
146AKT20.34332632
147GSK3A0.33446549
148CDK11A0.32858750
149PTK60.32510850

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047405.40832061
2Axon guidance_Homo sapiens_hsa043602.38914777
3Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.22488495
4Basal cell carcinoma_Homo sapiens_hsa052172.13061570
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12717283
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.11162374
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04250034
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.79319306
9Gastric acid secretion_Homo sapiens_hsa049711.73980094
10Hedgehog signaling pathway_Homo sapiens_hsa043401.70867122
11Cardiac muscle contraction_Homo sapiens_hsa042601.70833120
12Glutamatergic synapse_Homo sapiens_hsa047241.69711598
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69491641
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67505693
15Melanogenesis_Homo sapiens_hsa049161.66689569
16Hippo signaling pathway_Homo sapiens_hsa043901.61799864
17Circadian entrainment_Homo sapiens_hsa047131.51810415
18Linoleic acid metabolism_Homo sapiens_hsa005911.47875981
19Nicotine addiction_Homo sapiens_hsa050331.47689979
20Taste transduction_Homo sapiens_hsa047421.47523801
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46385397
22Oxidative phosphorylation_Homo sapiens_hsa001901.44889810
23Ribosome_Homo sapiens_hsa030101.44682821
24Phototransduction_Homo sapiens_hsa047441.43249147
25Nitrogen metabolism_Homo sapiens_hsa009101.42055204
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40233424
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.38270920
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37458644
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32037296
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31605440
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31221227
32Wnt signaling pathway_Homo sapiens_hsa043101.30975954
33Dopaminergic synapse_Homo sapiens_hsa047281.28407336
34ECM-receptor interaction_Homo sapiens_hsa045121.27982057
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26837235
36Cholinergic synapse_Homo sapiens_hsa047251.23804558
37Chemical carcinogenesis_Homo sapiens_hsa052041.21762184
38Insulin secretion_Homo sapiens_hsa049111.21417304
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19327146
40Glioma_Homo sapiens_hsa052141.18811347
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18204649
42Ovarian steroidogenesis_Homo sapiens_hsa049131.17278883
43Morphine addiction_Homo sapiens_hsa050321.17105543
44Gap junction_Homo sapiens_hsa045401.16695904
45GABAergic synapse_Homo sapiens_hsa047271.16521651
46Amphetamine addiction_Homo sapiens_hsa050311.16347952
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16319210
48Salivary secretion_Homo sapiens_hsa049701.16047600
49TGF-beta signaling pathway_Homo sapiens_hsa043501.15305307
50Tryptophan metabolism_Homo sapiens_hsa003801.14517350
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11480803
52GnRH signaling pathway_Homo sapiens_hsa049121.11459746
53Parkinsons disease_Homo sapiens_hsa050121.10307241
54Collecting duct acid secretion_Homo sapiens_hsa049661.09128999
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08755429
56Homologous recombination_Homo sapiens_hsa034401.08202040
57Alzheimers disease_Homo sapiens_hsa050101.07597835
58Thyroid hormone synthesis_Homo sapiens_hsa049181.07065288
59Protein digestion and absorption_Homo sapiens_hsa049741.06760227
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06312648
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05939836
62Glycerolipid metabolism_Homo sapiens_hsa005611.04935767
63cAMP signaling pathway_Homo sapiens_hsa040241.02212105
64Long-term potentiation_Homo sapiens_hsa047201.01638831
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00015042
66Notch signaling pathway_Homo sapiens_hsa043300.98897086
67Retinol metabolism_Homo sapiens_hsa008300.97216887
68MicroRNAs in cancer_Homo sapiens_hsa052060.96777366
69Synaptic vesicle cycle_Homo sapiens_hsa047210.96350310
70Fatty acid biosynthesis_Homo sapiens_hsa000610.95238986
71Cocaine addiction_Homo sapiens_hsa050300.94900951
72Tight junction_Homo sapiens_hsa045300.94354995
73Focal adhesion_Homo sapiens_hsa045100.94092346
74Sulfur metabolism_Homo sapiens_hsa009200.92562290
75Estrogen signaling pathway_Homo sapiens_hsa049150.91782954
76Endometrial cancer_Homo sapiens_hsa052130.91623751
77Type II diabetes mellitus_Homo sapiens_hsa049300.90633624
78Ether lipid metabolism_Homo sapiens_hsa005650.90283455
79Adherens junction_Homo sapiens_hsa045200.90248833
80Proteoglycans in cancer_Homo sapiens_hsa052050.90221894
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88955257
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87192416
83Rap1 signaling pathway_Homo sapiens_hsa040150.85918364
84Colorectal cancer_Homo sapiens_hsa052100.85644597
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85530553
86Dilated cardiomyopathy_Homo sapiens_hsa054140.84553706
87Fat digestion and absorption_Homo sapiens_hsa049750.84206019
88Melanoma_Homo sapiens_hsa052180.84108848
89Serotonergic synapse_Homo sapiens_hsa047260.83442515
90Huntingtons disease_Homo sapiens_hsa050160.83148121
91Renin-angiotensin system_Homo sapiens_hsa046140.83060381
92Butanoate metabolism_Homo sapiens_hsa006500.82562458
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82441387
94Long-term depression_Homo sapiens_hsa047300.81187346
95Oxytocin signaling pathway_Homo sapiens_hsa049210.80423489
96Fanconi anemia pathway_Homo sapiens_hsa034600.80331412
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79713668
98Oocyte meiosis_Homo sapiens_hsa041140.79526706
99Vibrio cholerae infection_Homo sapiens_hsa051100.79263979
100Bile secretion_Homo sapiens_hsa049760.77425975
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76943784
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75437502
103Vitamin digestion and absorption_Homo sapiens_hsa049770.74623661
104Sulfur relay system_Homo sapiens_hsa041220.74576980
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73829729
106Bladder cancer_Homo sapiens_hsa052190.73765935
107Basal transcription factors_Homo sapiens_hsa030220.72719082
108Calcium signaling pathway_Homo sapiens_hsa040200.72353040
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.71918957
110Chronic myeloid leukemia_Homo sapiens_hsa052200.71245762
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70606892
112MAPK signaling pathway_Homo sapiens_hsa040100.70217623
113ErbB signaling pathway_Homo sapiens_hsa040120.69429064
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.69251631
115Selenocompound metabolism_Homo sapiens_hsa004500.67449978
116Ras signaling pathway_Homo sapiens_hsa040140.64510723
117Dorso-ventral axis formation_Homo sapiens_hsa043200.63531672
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62988120
119Renin secretion_Homo sapiens_hsa049240.62849250
120Prostate cancer_Homo sapiens_hsa052150.60453378
121Caffeine metabolism_Homo sapiens_hsa002320.59745625
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59477155
123Small cell lung cancer_Homo sapiens_hsa052220.58037393
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.58036282
125Arachidonic acid metabolism_Homo sapiens_hsa005900.57359079
126Alcoholism_Homo sapiens_hsa050340.57174370
127Pathways in cancer_Homo sapiens_hsa052000.56947046
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55656193
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53779282
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.53401073
131Systemic lupus erythematosus_Homo sapiens_hsa053220.53288084
132Mineral absorption_Homo sapiens_hsa049780.52033037
133Pancreatic cancer_Homo sapiens_hsa052120.51590756
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49650972
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48369034
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48338658
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.47893083
138Amoebiasis_Homo sapiens_hsa051460.47406936
139Glucagon signaling pathway_Homo sapiens_hsa049220.45803804
140FoxO signaling pathway_Homo sapiens_hsa040680.45786801
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45230073
142RNA degradation_Homo sapiens_hsa030180.40290322

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