EN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)7.86092757
2response to pheromone (GO:0019236)7.30315707
3neuronal action potential propagation (GO:0019227)5.81424824
4cell differentiation in hindbrain (GO:0021533)5.75853793
5cerebellar Purkinje cell differentiation (GO:0021702)5.72767746
6locomotory exploration behavior (GO:0035641)5.43879609
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.30561447
8G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.27833960
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.09759673
10gamma-aminobutyric acid transport (GO:0015812)5.08872128
11dopaminergic neuron differentiation (GO:0071542)4.98632854
12glutamate receptor signaling pathway (GO:0007215)4.94358280
13axon ensheathment in central nervous system (GO:0032291)4.94072178
14central nervous system myelination (GO:0022010)4.94072178
15cellular potassium ion homeostasis (GO:0030007)4.92355970
16* hindbrain development (GO:0030902)4.89033967
17synaptic vesicle maturation (GO:0016188)4.70682383
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.56717367
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.51359345
20vocalization behavior (GO:0071625)4.49344948
21sodium ion export (GO:0071436)4.48745919
22neurotransmitter secretion (GO:0007269)4.45785716
23adult walking behavior (GO:0007628)4.44513152
24postsynaptic membrane organization (GO:0001941)4.44340945
25mating behavior (GO:0007617)4.39125375
26synaptic transmission, glutamatergic (GO:0035249)4.38829710
27layer formation in cerebral cortex (GO:0021819)4.37369018
28transmission of nerve impulse (GO:0019226)4.27315366
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23074538
30negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.17312102
31presynaptic membrane assembly (GO:0097105)4.14013538
32positive regulation of gastrulation (GO:2000543)4.07145199
33regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.06001077
34regulation of mesenchymal cell apoptotic process (GO:2001053)4.05662895
35negative regulation of microtubule polymerization (GO:0031115)4.05198492
36gamma-aminobutyric acid signaling pathway (GO:0007214)4.04211550
37synaptic vesicle exocytosis (GO:0016079)4.03809803
38pyrimidine nucleobase catabolic process (GO:0006208)4.03743148
39spinal cord development (GO:0021510)4.03639567
40neuromuscular process controlling posture (GO:0050884)4.01604369
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.99418703
42positive regulation of synapse maturation (GO:0090129)3.98748728
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.98583997
44neuronal stem cell maintenance (GO:0097150)3.95051308
45neuron-neuron synaptic transmission (GO:0007270)3.93301520
46dendritic spine morphogenesis (GO:0060997)3.92965461
47dorsal/ventral neural tube patterning (GO:0021904)3.90519560
48startle response (GO:0001964)3.87891021
49multicellular organismal movement (GO:0050879)3.87707154
50musculoskeletal movement (GO:0050881)3.87707154
51neurotransmitter transport (GO:0006836)3.85471293
52detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.84350432
53detection of temperature stimulus involved in sensory perception (GO:0050961)3.84350432
54proximal/distal pattern formation (GO:0009954)3.79742839
55limb bud formation (GO:0060174)3.79313944
56dendrite morphogenesis (GO:0048813)3.79200081
57neuron cell-cell adhesion (GO:0007158)3.78784100
58regulation of synaptic vesicle exocytosis (GO:2000300)3.77369517
59long-term memory (GO:0007616)3.75690162
60exploration behavior (GO:0035640)3.71961161
61C4-dicarboxylate transport (GO:0015740)3.71260109
62behavioral response to nicotine (GO:0035095)3.69269556
63negative regulation of neurotransmitter transport (GO:0051589)3.66099483
64potassium ion import (GO:0010107)3.63693201
65* midbrain development (GO:0030901)3.62245507
66positive regulation of synapse assembly (GO:0051965)3.61335294
67glutamate secretion (GO:0014047)3.59651857
68cell migration in hindbrain (GO:0021535)3.58021738
69neuromuscular process controlling balance (GO:0050885)3.57554673
70regulation of neurotransmitter levels (GO:0001505)3.56770287
71neuron remodeling (GO:0016322)3.54050123
72establishment of planar polarity (GO:0001736)3.49886896
73establishment of tissue polarity (GO:0007164)3.49886896
74tongue development (GO:0043586)3.45563186
75somite rostral/caudal axis specification (GO:0032525)3.43057970
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42679111
77detection of temperature stimulus (GO:0016048)3.41590935
78potassium ion homeostasis (GO:0055075)3.41512214
79serotonin metabolic process (GO:0042428)3.41175835
80proline transport (GO:0015824)3.40267850
81nonmotile primary cilium assembly (GO:0035058)3.39863820
82presynaptic membrane organization (GO:0097090)3.39825602
83cilium or flagellum-dependent cell motility (GO:0001539)3.38918176
84neuron fate specification (GO:0048665)3.38188739
85synaptic vesicle endocytosis (GO:0048488)3.35487551
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33818066
87regulation of glutamate receptor signaling pathway (GO:1900449)3.33081201
88axonemal dynein complex assembly (GO:0070286)3.31843084
89regulation of excitatory postsynaptic membrane potential (GO:0060079)3.30533647
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29901726
91neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.28329120
92negative regulation of protein localization to cell surface (GO:2000009)3.27491360
93neurotransmitter uptake (GO:0001504)3.27406052
94establishment of nucleus localization (GO:0040023)3.24110974
95regulation of synapse maturation (GO:0090128)3.22926792
96uterus development (GO:0060065)3.22799042
97neuromuscular synaptic transmission (GO:0007274)3.20234640
98forebrain neuron differentiation (GO:0021879)3.19420903
99primitive streak formation (GO:0090009)3.19420517
100regulation of respiratory system process (GO:0044065)3.19240411
101membrane hyperpolarization (GO:0060081)3.18599539
102protein localization to synapse (GO:0035418)3.18224171
103cerebral cortex radially oriented cell migration (GO:0021799)3.17432247
104retinal ganglion cell axon guidance (GO:0031290)3.17168486
105prepulse inhibition (GO:0060134)3.16036087
106regulation of postsynaptic membrane potential (GO:0060078)3.11633748
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11492769
108cell communication by electrical coupling (GO:0010644)3.11236577
109positive regulation of potassium ion transmembrane transport (GO:1901381)3.10951477
110detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10770444
111regulation of synaptic vesicle transport (GO:1902803)3.10487701
112glycine transport (GO:0015816)3.08869637
113mechanosensory behavior (GO:0007638)3.08201452
114regulation of respiratory gaseous exchange (GO:0043576)3.08138772
115neuron fate determination (GO:0048664)3.08095111
116dopamine biosynthetic process (GO:0042416)3.08060174
117heart valve formation (GO:0003188)3.07807383
118neuron recognition (GO:0008038)3.07289091
119membrane depolarization (GO:0051899)3.05246961
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04870330
121regulation of voltage-gated calcium channel activity (GO:1901385)3.04790122
122primary amino compound metabolic process (GO:1901160)3.04674997
123membrane depolarization during action potential (GO:0086010)3.04663944
124cerebellar Purkinje cell layer development (GO:0021680)3.04660263
125cerebellum development (GO:0021549)3.04316427
126negative regulation of smooth muscle cell differentiation (GO:0051151)3.03846492
127negative regulation of oligodendrocyte differentiation (GO:0048715)3.03779863
128response to auditory stimulus (GO:0010996)3.03316569
129neuronal ion channel clustering (GO:0045161)3.02489251
130regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02127122
131synapse organization (GO:0050808)3.01999565
132negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99841912
133negative regulation of translation, ncRNA-mediated (GO:0040033)2.99841912
134regulation of translation, ncRNA-mediated (GO:0045974)2.99841912
135axonal fasciculation (GO:0007413)2.99233281
136regulation of synapse structural plasticity (GO:0051823)2.99021836
137cell-cell signaling involved in cell fate commitment (GO:0045168)2.98837666
138nucleobase catabolic process (GO:0046113)2.97442399
139positive regulation of membrane potential (GO:0045838)2.96165646
140auditory behavior (GO:0031223)2.93036408
141neuron maturation (GO:0042551)2.92977577
142central nervous system projection neuron axonogenesis (GO:0021952)2.92834881
143adult locomotory behavior (GO:0008344)2.92313543
144neuronal action potential (GO:0019228)2.92271606
145regulation of calcium ion-dependent exocytosis (GO:0017158)2.91883259
146behavioral response to cocaine (GO:0048148)2.90456126
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.90367917
148lateral sprouting from an epithelium (GO:0060601)2.87931527
149establishment of protein localization to mitochondrial membrane (GO:0090151)2.87311557
150epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.84932586
151negative regulation of inclusion body assembly (GO:0090084)2.82685157
152pattern specification involved in kidney development (GO:0061004)2.81572237
153negative regulation of axon guidance (GO:1902668)2.78590647
154artery development (GO:0060840)2.77793664
155inner ear receptor stereocilium organization (GO:0060122)2.77350436
156detection of mechanical stimulus involved in sensory perception (GO:0050974)2.76850727
157regulation of synapse assembly (GO:0051963)2.76470103
158cochlea morphogenesis (GO:0090103)2.74438511
159thalamus development (GO:0021794)2.72136925
160somite development (GO:0061053)2.69313401
161microtubule depolymerization (GO:0007019)2.68808176
162planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68613475
163developmental induction (GO:0031128)2.68324454
164skeletal muscle organ development (GO:0060538)2.66601754
165cellular response to ATP (GO:0071318)2.64816054
166DNA damage response, detection of DNA damage (GO:0042769)2.62617526
167endocardial cushion morphogenesis (GO:0003203)2.61257483
168regulation of axon guidance (GO:1902667)2.61150718
169cranial nerve morphogenesis (GO:0021602)2.60883165
170forebrain development (GO:0030900)2.60795139
171neurotransmitter-gated ion channel clustering (GO:0072578)2.59006236
172positive regulation of embryonic development (GO:0040019)2.58434904
173cell proliferation in forebrain (GO:0021846)2.55981706
174viral transcription (GO:0019083)2.54747158
175mesenchyme morphogenesis (GO:0072132)2.50116629
176cell fate specification (GO:0001708)2.49802105
177translational termination (GO:0006415)2.49692313
178camera-type eye morphogenesis (GO:0048593)2.49433521
179negative regulation of astrocyte differentiation (GO:0048712)2.48507229
180negative regulation of glial cell differentiation (GO:0045686)2.47570750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.20073796
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.35094555
3IKZF1_21737484_ChIP-ChIP_HCT116_Human3.06791565
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05963730
5* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.01458586
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.01458586
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94286862
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.71290450
9DROSHA_22980978_ChIP-Seq_HELA_Human2.58869269
10* EZH2_27294783_Chip-Seq_ESCs_Mouse2.56314802
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55509799
12REST_21632747_ChIP-Seq_MESCs_Mouse2.54989450
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53969872
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52706947
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52587401
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47444354
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.46957269
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42842981
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.39822156
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.36788449
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.31694691
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31353147
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28594256
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28457587
25GBX2_23144817_ChIP-Seq_PC3_Human2.26195461
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22752138
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.11101952
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10494161
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07988473
30* ERG_21242973_ChIP-ChIP_JURKAT_Human2.04609574
31ZNF274_21170338_ChIP-Seq_K562_Hela1.85333713
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.85030543
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82057341
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76123050
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70115424
36EWS_26573619_Chip-Seq_HEK293_Human1.69227644
37* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66559365
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63539597
39* RING1B_27294783_Chip-Seq_NPCs_Mouse1.60412426
40* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56334707
41* CBX2_27304074_Chip-Seq_ESCs_Mouse1.54354292
42FUS_26573619_Chip-Seq_HEK293_Human1.51220357
43* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50155045
44* RING1B_27294783_Chip-Seq_ESCs_Mouse1.50109746
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49881434
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45023111
47* KDM2B_26808549_Chip-Seq_K562_Human1.40990677
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39433800
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.38624760
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35599334
51* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34898710
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32819341
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31490805
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31334027
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28116733
56* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27775873
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26862819
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26404451
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26268834
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23973562
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22765472
62* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22071613
63* AR_19668381_ChIP-Seq_PC3_Human1.18034193
64AR_21572438_ChIP-Seq_LNCaP_Human1.16321538
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15333894
66SMAD4_21799915_ChIP-Seq_A2780_Human1.15149446
67TP53_16413492_ChIP-PET_HCT116_Human1.14954887
68* RNF2_27304074_Chip-Seq_NSC_Mouse1.14764955
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12684755
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12684755
71* TP53_20018659_ChIP-ChIP_R1E_Mouse1.12254247
72LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11470507
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09135942
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08818757
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07071651
76* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06741668
77SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06168795
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04791299
79* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04057421
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03777617
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03687045
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03468045
83* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03265380
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02549133
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.01090170
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00344239
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99586009
88TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99166834
89AR_25329375_ChIP-Seq_VCAP_Human0.98332727
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.98211661
91TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97708939
92TAF15_26573619_Chip-Seq_HEK293_Human0.97458596
93* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97059253
94SOX9_26525672_Chip-Seq_HEART_Mouse0.97031017
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97024643
96SALL1_21062744_ChIP-ChIP_HESCs_Human0.96630892
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.96552799
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96536953
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96482554
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96093071
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95798960
102* STAT3_23295773_ChIP-Seq_U87_Human0.95350903
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95302908
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93415395
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92805775
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92533629
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.91998988
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91296529
109P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91262422
110VDR_22108803_ChIP-Seq_LS180_Human0.89971894
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.89805453
112* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89558446
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89237074
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89095542
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.89072941
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88961484
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87982939
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85803863
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85203924
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85133539
121P300_19829295_ChIP-Seq_ESCs_Human0.85112020
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85067259
123RUNX2_22187159_ChIP-Seq_PCA_Human0.84985347
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.84773248
125TCF4_23295773_ChIP-Seq_U87_Human0.84544282
126GATA1_26923725_Chip-Seq_HPCs_Mouse0.84412311
127IGF1R_20145208_ChIP-Seq_DFB_Human0.83993445
128RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83805589
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83551508
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82090067
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81439817
132ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81439638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch4.50425380
2MP0004859_abnormal_synaptic_plasticity4.35617397
3MP0000569_abnormal_digit_pigmentation3.94257959
4MP0003635_abnormal_synaptic_transmissio3.51759639
5MP0003880_abnormal_central_pattern3.26546517
6MP0004145_abnormal_muscle_electrophysio3.05429767
7MP0005423_abnormal_somatic_nervous3.02226612
8MP0008569_lethality_at_weaning2.95689755
9MP0002272_abnormal_nervous_system2.93989922
10MP0002064_seizures2.91421840
11MP0004270_analgesia2.85835396
12MP0009745_abnormal_behavioral_response2.71286784
13MP0004885_abnormal_endolymph2.56999976
14MP0002734_abnormal_mechanical_nocicepti2.54433389
15* MP0002067_abnormal_sensory_capabilities2.52524102
16MP0002184_abnormal_innervation2.51981852
17MP0004742_abnormal_vestibular_system2.50321715
18MP0004142_abnormal_muscle_tone2.49193313
19MP0001486_abnormal_startle_reflex2.46236514
20* MP0002572_abnormal_emotion/affect_behav2.45169980
21* MP0002063_abnormal_learning/memory/cond2.38654857
22MP0000778_abnormal_nervous_system2.33412257
23MP0003315_abnormal_perineum_morphology2.18731180
24MP0001968_abnormal_touch/_nociception2.08362218
25* MP0001440_abnormal_grooming_behavior2.03865552
26MP0001501_abnormal_sleep_pattern2.03697846
27MP0003632_abnormal_nervous_system1.95033257
28MP0002733_abnormal_thermal_nociception1.94882152
29MP0000955_abnormal_spinal_cord1.94643556
30MP0002735_abnormal_chemical_nociception1.92257987
31MP0000049_abnormal_middle_ear1.85717559
32MP0000920_abnormal_myelination1.83583772
33MP0009379_abnormal_foot_pigmentation1.82213934
34MP0001986_abnormal_taste_sensitivity1.81818687
35MP0003121_genomic_imprinting1.76007634
36MP0001970_abnormal_pain_threshold1.69707018
37MP0003119_abnormal_digestive_system1.67948109
38* MP0002066_abnormal_motor_capabilities/c1.67281455
39* MP0002557_abnormal_social/conspecific_i1.65519322
40MP0003329_amyloid_beta_deposits1.64101575
41MP0006276_abnormal_autonomic_nervous1.61589417
42MP0001905_abnormal_dopamine_level1.61209820
43MP0002938_white_spotting1.59807060
44MP0002736_abnormal_nociception_after1.59141043
45* MP0005386_behavior/neurological_phenoty1.58351142
46* MP0004924_abnormal_behavior1.58351142
47MP0002882_abnormal_neuron_morphology1.57918001
48MP0002249_abnormal_larynx_morphology1.55538353
49MP0003937_abnormal_limbs/digits/tail_de1.54032866
50MP0009053_abnormal_anal_canal1.47186547
51MP0004811_abnormal_neuron_physiology1.42484670
52MP0003690_abnormal_glial_cell1.41910631
53MP0000534_abnormal_ureter_morphology1.41905215
54* MP0002152_abnormal_brain_morphology1.39016733
55MP0003942_abnormal_urinary_system1.38631472
56MP0002277_abnormal_respiratory_mucosa1.32525856
57MP0001346_abnormal_lacrimal_gland1.30549945
58MP0002697_abnormal_eye_size1.28841969
59MP0002102_abnormal_ear_morphology1.26243613
60MP0001485_abnormal_pinna_reflex1.25812429
61MP0003283_abnormal_digestive_organ1.25212317
62MP0003634_abnormal_glial_cell1.24827285
63MP0003631_nervous_system_phenotype1.24034317
64MP0001293_anophthalmia1.21995721
65MP0001286_abnormal_eye_development1.21230388
66MP0000566_synostosis1.21148031
67MP0009250_abnormal_appendicular_skeleto1.20932436
68MP0001299_abnormal_eye_distance/1.18963755
69MP0002282_abnormal_trachea_morphology1.17430944
70MP0006072_abnormal_retinal_apoptosis1.12100742
71MP0002229_neurodegeneration1.11161741
72MP0002752_abnormal_somatic_nervous1.08990231
73MP0003755_abnormal_palate_morphology1.08205162
74MP0002909_abnormal_adrenal_gland1.06103948
75MP0005187_abnormal_penis_morphology1.05181779
76MP0005623_abnormal_meninges_morphology1.04572251
77MP0003137_abnormal_impulse_conducting1.03884494
78MP0001963_abnormal_hearing_physiology1.02023007
79MP0003938_abnormal_ear_development1.00517664
80* MP0003861_abnormal_nervous_system1.00277852
81MP0001324_abnormal_eye_pigmentation0.99698212
82MP0002932_abnormal_joint_morphology0.99696133
83MP0005646_abnormal_pituitary_gland0.99585471
84MP0003633_abnormal_nervous_system0.99172400
85MP0003123_paternal_imprinting0.98082277
86MP0003935_abnormal_craniofacial_develop0.97020377
87MP0002160_abnormal_reproductive_system0.96104626
88MP0002116_abnormal_craniofacial_bone0.95792106
89MP0005499_abnormal_olfactory_system0.95741998
90MP0005394_taste/olfaction_phenotype0.95741998
91MP0004147_increased_porphyrin_level0.95327290
92MP0000537_abnormal_urethra_morphology0.94597535
93MP0002751_abnormal_autonomic_nervous0.91281257
94MP0001502_abnormal_circadian_rhythm0.90732911
95MP0003122_maternal_imprinting0.90537696
96MP0005171_absent_coat_pigmentation0.90264410
97MP0004858_abnormal_nervous_system0.90221916
98MP0005551_abnormal_eye_electrophysiolog0.89596394
99MP0000647_abnormal_sebaceous_gland0.89485210
100MP0005174_abnormal_tail_pigmentation0.86077505
101MP0002233_abnormal_nose_morphology0.85379879
102MP0002095_abnormal_skin_pigmentation0.83096400
103MP0000762_abnormal_tongue_morphology0.83088173
104MP0005391_vision/eye_phenotype0.82053294
105MP0002822_catalepsy0.81773777
106MP0002081_perinatal_lethality0.81755267
107MP0003787_abnormal_imprinting0.81430863
108MP0000026_abnormal_inner_ear0.81180520
109MP0000462_abnormal_digestive_system0.80790411
110MP0002092_abnormal_eye_morphology0.80631752
111MP0005389_reproductive_system_phenotype0.79981994
112MP0005503_abnormal_tendon_morphology0.79832849
113MP0000372_irregular_coat_pigmentation0.79418387
114MP0002638_abnormal_pupillary_reflex0.78760821
115MP0005195_abnormal_posterior_eye0.77991967
116MP0010769_abnormal_survival0.77807477
117MP0008872_abnormal_physiological_respon0.76801767
118MP0004043_abnormal_pH_regulation0.74896524
119MP0004215_abnormal_myocardial_fiber0.74658108
120MP0010768_mortality/aging0.74412893
121MP0005253_abnormal_eye_physiology0.73781712
122MP0001943_abnormal_respiration0.71623483
123MP0002082_postnatal_lethality0.71270391
124MP0010770_preweaning_lethality0.71270391
125MP0002069_abnormal_eating/drinking_beha0.71241399
126MP0005645_abnormal_hypothalamus_physiol0.70559616
127MP0000747_muscle_weakness0.68782174
128MP0003890_abnormal_embryonic-extraembry0.68152040
129MP0002653_abnormal_ependyma_morphology0.67743078
130MP0001188_hyperpigmentation0.64035973
131MP0004133_heterotaxia0.63190807
132MP0006292_abnormal_olfactory_placode0.62971883
133MP0000631_abnormal_neuroendocrine_gland0.62589789
134MP0003136_yellow_coat_color0.62470254
135MP0001984_abnormal_olfaction0.61223745
136MP0004085_abnormal_heartbeat0.58739171
137MP0005083_abnormal_biliary_tract0.57524933
138MP0005409_darkened_coat_color0.57449199
139MP0000604_amyloidosis0.53956308
140MP0002234_abnormal_pharynx_morphology0.52976226
141MP0001529_abnormal_vocalization0.52494164
142MP0005535_abnormal_body_temperature0.51340759

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)6.62489577
2Progressive cerebellar ataxia (HP:0002073)6.57259677
3Visual hallucinations (HP:0002367)5.69092354
4Intention tremor (HP:0002080)4.76353125
5Scanning speech (HP:0002168)4.71294712
6Focal motor seizures (HP:0011153)4.66063827
7Myokymia (HP:0002411)4.64713448
8Gaze-evoked nystagmus (HP:0000640)4.57575301
9Focal seizures (HP:0007359)4.49399937
10Atonic seizures (HP:0010819)4.33059077
11Dysdiadochokinesis (HP:0002075)4.16348606
12Dysmetria (HP:0001310)3.99373432
13Impaired smooth pursuit (HP:0007772)3.87082670
14Broad-based gait (HP:0002136)3.84073906
15Dysmetric saccades (HP:0000641)3.82984069
16Hemiplegia (HP:0002301)3.71375440
17Abnormality of ocular smooth pursuit (HP:0000617)3.63362975
18Supranuclear gaze palsy (HP:0000605)3.46212021
19Absence seizures (HP:0002121)3.45981326
20Postural tremor (HP:0002174)3.42823485
21Genetic anticipation (HP:0003743)3.37317274
22Febrile seizures (HP:0002373)3.33357353
23Hemiparesis (HP:0001269)3.31487712
24Abnormal respiratory motile cilium morphology (HP:0005938)3.31134745
25Abnormal respiratory epithelium morphology (HP:0012253)3.31134745
26Epileptic encephalopathy (HP:0200134)3.27723761
27Abnormality of the corticospinal tract (HP:0002492)3.27499127
28Hyperventilation (HP:0002883)3.24329802
29Morphological abnormality of the middle ear (HP:0008609)3.20039230
30Concave nail (HP:0001598)3.19788536
31Horizontal nystagmus (HP:0000666)3.13424258
32Abnormality of binocular vision (HP:0011514)3.07807265
33Diplopia (HP:0000651)3.07807265
34Abnormality of the 4th metacarpal (HP:0010012)3.06309241
35Dialeptic seizures (HP:0011146)3.04624241
36Abnormal number of incisors (HP:0011064)3.02206998
37Truncal ataxia (HP:0002078)3.01833931
38Bilateral microphthalmos (HP:0007633)2.96945825
39Abnormality of saccadic eye movements (HP:0000570)2.96642696
40Esophageal atresia (HP:0002032)2.94175961
41Morphological abnormality of the pyramidal tract (HP:0002062)2.93120873
42Neurofibrillary tangles (HP:0002185)2.78869358
43Short 4th metacarpal (HP:0010044)2.75786583
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75786583
45Limb dystonia (HP:0002451)2.71495885
46Protruding tongue (HP:0010808)2.68133037
47Oligodactyly (hands) (HP:0001180)2.67550334
48Midline defect of the nose (HP:0004122)2.66632834
49Amyotrophic lateral sclerosis (HP:0007354)2.66522416
50Cerebral inclusion bodies (HP:0100314)2.64253525
51Enlarged penis (HP:0000040)2.61737211
52Volvulus (HP:0002580)2.61479287
53Abnormality of the lower motor neuron (HP:0002366)2.61261894
54Generalized tonic-clonic seizures (HP:0002069)2.59169356
55Spastic gait (HP:0002064)2.55488217
56Tetraplegia (HP:0002445)2.53091974
57Annular pancreas (HP:0001734)2.52910139
58Exotropia (HP:0000577)2.52500806
59Neonatal short-limb short stature (HP:0008921)2.50014061
60Status epilepticus (HP:0002133)2.48843052
61Cerebral hypomyelination (HP:0006808)2.48497254
62Agitation (HP:0000713)2.47006691
63Peripheral hypomyelination (HP:0007182)2.41258004
64Gait ataxia (HP:0002066)2.41112597
65Depression (HP:0000716)2.39128299
66True hermaphroditism (HP:0010459)2.38972987
67Maternal diabetes (HP:0009800)2.35507628
68Anxiety (HP:0000739)2.32537728
69Mutism (HP:0002300)2.30490551
70Morphological abnormality of the inner ear (HP:0011390)2.29714434
71Patellar aplasia (HP:0006443)2.29363426
72Aplasia/Hypoplasia of the patella (HP:0006498)2.29339760
73Poor eye contact (HP:0000817)2.29165267
74Aqueductal stenosis (HP:0002410)2.26738812
75Ventricular fibrillation (HP:0001663)2.26023101
76Birth length less than 3rd percentile (HP:0003561)2.25261209
77Anencephaly (HP:0002323)2.23928207
78Rib fusion (HP:0000902)2.21521097
79Synostosis involving the elbow (HP:0003938)2.20892501
80Humeroradial synostosis (HP:0003041)2.20892501
81Limb ataxia (HP:0002070)2.19369137
82Cortical dysplasia (HP:0002539)2.18502321
83Gastrointestinal atresia (HP:0002589)2.18101585
84Ankle clonus (HP:0011448)2.14941140
85Down-sloping shoulders (HP:0200021)2.13503916
86Abnormal social behavior (HP:0012433)2.13357456
87Impaired social interactions (HP:0000735)2.13357456
88Neuronal loss in central nervous system (HP:0002529)2.13281221
89Shawl scrotum (HP:0000049)2.12646643
90Chronic otitis media (HP:0000389)2.10711817
91Pheochromocytoma (HP:0002666)2.10704417
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.10591278
93Lower limb asymmetry (HP:0100559)2.10351556
94Type II lissencephaly (HP:0007260)2.09068571
95Megalencephaly (HP:0001355)2.07831481
96Hemivertebrae (HP:0002937)2.06944821
97Shallow orbits (HP:0000586)2.06336897
98Abnormality of chromosome segregation (HP:0002916)2.04422539
99Abnormality of the aortic arch (HP:0012303)2.02867294
100Anteriorly placed anus (HP:0001545)2.01378199
101Abnormal eating behavior (HP:0100738)2.01203930
102Septo-optic dysplasia (HP:0100842)2.00624346
103Retinal dysplasia (HP:0007973)2.00549151
104Drooling (HP:0002307)2.00120246
105Excessive salivation (HP:0003781)2.00120246
106Slow progression (HP:0003677)1.99196505
107Chronic sinusitis (HP:0011109)1.98359966
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97868645
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.97868645
110Fetal akinesia sequence (HP:0001989)1.97260078
111Blue irides (HP:0000635)1.93700010
112Radial bowing (HP:0002986)1.93239344
113Postural instability (HP:0002172)1.93154683
114Abnormality of the incisor (HP:0000676)1.92484752
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.91676951
116Fibular hypoplasia (HP:0003038)1.91511293
117Clonus (HP:0002169)1.90877834
118Supernumerary bones of the axial skeleton (HP:0009144)1.90508526
119Split foot (HP:0001839)1.90209125
120Spastic tetraparesis (HP:0001285)1.88735739
121Trigonocephaly (HP:0000243)1.87784311
122Supernumerary ribs (HP:0005815)1.86989130
123Hypothermia (HP:0002045)1.86662078
124Narrow nasal bridge (HP:0000446)1.86533269
125White forelock (HP:0002211)1.85756460
126Lissencephaly (HP:0001339)1.85516266
127Psychosis (HP:0000709)1.85171356
128Clumsiness (HP:0002312)1.84969334
129Oligodactyly (HP:0012165)1.84491751
130Abnormality of midbrain morphology (HP:0002418)1.83799245
131Molar tooth sign on MRI (HP:0002419)1.83799245
132Sensory axonal neuropathy (HP:0003390)1.83052319
133Preaxial hand polydactyly (HP:0001177)1.82697563
134Incomplete penetrance (HP:0003829)1.82664904
135Generalized hypotonia (HP:0001290)1.82362688
136Alacrima (HP:0000522)1.81068909
13711 pairs of ribs (HP:0000878)1.80374991
138Abnormality of the diencephalon (HP:0010662)1.80222915
139Myotonia (HP:0002486)1.80130311
140Abnormality of the ischium (HP:0003174)1.79826884
141Tented upper lip vermilion (HP:0010804)1.79762043
142Abnormality of the phalanges of the hallux (HP:0010057)1.79716103
143Short tibia (HP:0005736)1.79072888
144Missing ribs (HP:0000921)1.78972306
145Hypoplastic pelvis (HP:0008839)1.78366302
146Nephronophthisis (HP:0000090)1.77815814
147Double outlet right ventricle (HP:0001719)1.76465487
148Congenital malformation of the right heart (HP:0011723)1.76465487
149Insidious onset (HP:0003587)1.76300471
150Termporal pattern (HP:0011008)1.76300471
151Heterochromia iridis (HP:0001100)1.75954322
152CNS hypomyelination (HP:0003429)1.75561313
153Pointed chin (HP:0000307)1.74612906
154Abnormality of the labia minora (HP:0012880)1.74116737
155Intestinal atresia (HP:0011100)1.73665399
156Sclerocornea (HP:0000647)1.73583018
157Abnormality of the parathyroid morphology (HP:0011766)1.72842509
158Pancreatic fibrosis (HP:0100732)1.72683024
159Anophthalmia (HP:0000528)1.72516101
160Amblyopia (HP:0000646)1.72400880
161Patchy hypopigmentation of hair (HP:0011365)1.72182529
162Neoplasm of the heart (HP:0100544)1.71721398
163Abnormality of the middle phalanges of the toes (HP:0010183)1.70922754
164Pseudobulbar signs (HP:0002200)1.70719816
165Infantile muscular hypotonia (HP:0008947)1.70403320
166Congenital sensorineural hearing impairment (HP:0008527)1.70230161
167Anterior segment dysgenesis (HP:0007700)1.69856008
168Aplasia/Hypoplasia of the fibula (HP:0006492)1.69814162
169Cutaneous finger syndactyly (HP:0010554)1.68941285
170Optic nerve hypoplasia (HP:0000609)1.68720180
171Congenital stationary night blindness (HP:0007642)1.68156261
172Akinesia (HP:0002304)1.68031203
173Hypoplastic nipples (HP:0002557)1.68004978
174Absent septum pellucidum (HP:0001331)1.67665875
175Preaxial foot polydactyly (HP:0001841)1.66139146
176Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.64956711
177Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.63299016
178Holoprosencephaly (HP:0001360)1.62115255
179Specific learning disability (HP:0001328)1.60184770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.82091778
2PNCK3.59369570
3MAPK153.57729527
4CDK193.15779200
5PAK63.11506605
6MARK12.86193635
7WNK12.76283657
8CAMKK22.58393614
9STK392.54030481
10UHMK12.45978845
11INSRR2.42628838
12OXSR12.31099089
13TSSK62.25778002
14NTRK32.19319904
15MAP3K42.06465132
16NTRK21.99462899
17RIPK11.97021541
18MINK11.96197409
19MAP3K91.93910527
20TYRO31.90245456
21DYRK31.74348770
22MKNK21.73198776
23CAMKK11.58858556
24ALK1.58671627
25CSNK1G31.58497897
26PLK41.55817910
27STK111.55513884
28MAPKAPK51.53128293
29CSNK1G21.47718349
30TNIK1.44493203
31MAPK131.42454902
32PKN11.35489210
33LATS21.35163581
34CDK151.34996381
35ICK1.30840324
36EPHB11.30127524
37LIMK11.28253809
38STK381.27886081
39CDK181.27422095
40CAMK2G1.24395761
41CDK11A1.24283142
42MKNK11.23891934
43PRKCG1.20933774
44GRK51.20547082
45CDK141.19838082
46CSNK1G11.18381073
47CAMK1G1.16965132
48MAP2K41.15890633
49MAP2K71.15090059
50CAMK2B1.14399948
51ROCK21.13833022
52CDK51.13829254
53PRPF4B1.12940655
54SIK21.12543790
55FGR1.12542470
56CAMK1D1.12136809
57DAPK21.10050914
58CDK31.09305381
59KSR11.09232299
60CAMK2A1.04542231
61DYRK1A1.01890465
62NTRK11.01846052
63PHKG11.00947618
64PHKG21.00947618
65CSNK1A1L1.00588717
66BCR0.97373390
67PTK60.96228770
68WNK40.94658794
69VRK10.93388078
70ADRBK20.93198821
71SGK4940.92055623
72SGK2230.92055623
73WNK30.88798844
74IRAK10.87487987
75CAMK40.85918885
76CAMK2D0.83819478
77PLK20.83222528
78TLK10.82929134
79BUB10.80429618
80MAP3K100.78699712
81PRKCH0.77438784
82SGK20.76648933
83CAMK10.76153753
84FGFR20.75890159
85MARK20.75388318
86FYN0.75199114
87HIPK20.73506017
88RPS6KA40.72631974
89FGFR10.71064098
90ERBB30.70455567
91PAK30.69587305
92TAF10.69007578
93DYRK1B0.68780004
94PRKG10.68259065
95EPHA40.67411236
96NEK20.66605462
97TAOK10.66476972
98CDC42BPA0.64088469
99BMX0.62797158
100MOS0.59365801
101IRAK20.59079919
102BRD40.57333646
103CASK0.56503541
104MAPK90.56459626
105RPS6KA30.56130621
106BMPR1B0.55851851
107KSR20.55819695
108CSNK1E0.55749992
109PTK20.54418995
110MAPK100.54206444
111CHEK20.50843211
112EPHB20.48997625
113NEK60.48592336
114ERBB20.48000514
115YES10.47358216
116PRKDC0.45569901
117PASK0.45273668
118CSNK1A10.44818539
119CSNK1D0.44017723
120DYRK20.43408310
121PRKCZ0.43187596
122FES0.43141944
123SGK10.43053392
124PLK30.42436963
125PRKACB0.42263046
126RET0.41544869
127RIPK40.41277997
128RPS6KA60.40950440
129* PRKACA0.40883120
130RPS6KA50.39485620
131PINK10.39076145
132ATR0.35744108
133CHUK0.35259734
134PRKCE0.35111799
135TGFBR10.33315155
136MAP2K20.33268472
137CDC70.31766750
138AURKA0.30739758
139RPS6KA20.30356020
140ADRBK10.29502927
141NME10.26159433
142PAK20.24921232
143VRK20.24839696
144TRIM280.24741290
145ATM0.24674276
146BRSK10.24408211

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.52534399
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.71112689
3Glutamatergic synapse_Homo sapiens_hsa047243.17954664
4Ribosome_Homo sapiens_hsa030102.90798619
5Long-term depression_Homo sapiens_hsa047302.83299517
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82408311
7Synaptic vesicle cycle_Homo sapiens_hsa047212.80949879
8GABAergic synapse_Homo sapiens_hsa047272.77445330
9Long-term potentiation_Homo sapiens_hsa047202.61491093
10Circadian entrainment_Homo sapiens_hsa047132.47263514
11Taste transduction_Homo sapiens_hsa047422.42015523
12Morphine addiction_Homo sapiens_hsa050322.32712622
13Amphetamine addiction_Homo sapiens_hsa050312.24402967
14Salivary secretion_Homo sapiens_hsa049702.02254140
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.98936432
16Dopaminergic synapse_Homo sapiens_hsa047281.97929576
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95729018
18Serotonergic synapse_Homo sapiens_hsa047261.87987996
19Gastric acid secretion_Homo sapiens_hsa049711.83541257
20RNA polymerase_Homo sapiens_hsa030201.80880441
21Phototransduction_Homo sapiens_hsa047441.69901403
22Cocaine addiction_Homo sapiens_hsa050301.64593687
23Cholinergic synapse_Homo sapiens_hsa047251.61691554
24Sulfur relay system_Homo sapiens_hsa041221.60487411
25Parkinsons disease_Homo sapiens_hsa050121.58247886
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58162970
27Cardiac muscle contraction_Homo sapiens_hsa042601.56576052
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54036200
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51855258
30Axon guidance_Homo sapiens_hsa043601.46501521
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44623077
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42369328
33Insulin secretion_Homo sapiens_hsa049111.39629482
34Gap junction_Homo sapiens_hsa045401.39017386
35Oxytocin signaling pathway_Homo sapiens_hsa049211.38642409
36Type II diabetes mellitus_Homo sapiens_hsa049301.37388709
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33458928
38Steroid biosynthesis_Homo sapiens_hsa001001.33056012
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32559641
40Calcium signaling pathway_Homo sapiens_hsa040201.20218329
41Fanconi anemia pathway_Homo sapiens_hsa034601.19960773
42Huntingtons disease_Homo sapiens_hsa050161.19764066
43Renin secretion_Homo sapiens_hsa049241.18300638
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18047468
45Estrogen signaling pathway_Homo sapiens_hsa049151.17530549
46cAMP signaling pathway_Homo sapiens_hsa040241.17357402
47Nitrogen metabolism_Homo sapiens_hsa009101.15707078
48Hedgehog signaling pathway_Homo sapiens_hsa043401.11712870
49Spliceosome_Homo sapiens_hsa030401.10385116
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10233247
51Pancreatic secretion_Homo sapiens_hsa049721.10115065
52Olfactory transduction_Homo sapiens_hsa047401.07027790
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.06581756
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06122683
55GnRH signaling pathway_Homo sapiens_hsa049121.05079190
56Thyroid hormone synthesis_Homo sapiens_hsa049180.99750765
57Linoleic acid metabolism_Homo sapiens_hsa005910.98769593
58TGF-beta signaling pathway_Homo sapiens_hsa043500.98441431
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94635275
60Protein export_Homo sapiens_hsa030600.93964266
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92444446
62Ovarian steroidogenesis_Homo sapiens_hsa049130.92336652
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91951710
64Cell cycle_Homo sapiens_hsa041100.91684045
65ErbB signaling pathway_Homo sapiens_hsa040120.90111915
66Dorso-ventral axis formation_Homo sapiens_hsa043200.87441002
67Choline metabolism in cancer_Homo sapiens_hsa052310.86664119
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84496571
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83539567
70Oocyte meiosis_Homo sapiens_hsa041140.81790121
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81341343
72Prion diseases_Homo sapiens_hsa050200.81110472
73Melanogenesis_Homo sapiens_hsa049160.76844554
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76319273
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75581470
76MAPK signaling pathway_Homo sapiens_hsa040100.75416267
77Renal cell carcinoma_Homo sapiens_hsa052110.73982594
78Inositol phosphate metabolism_Homo sapiens_hsa005620.72276077
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69735991
80Melanoma_Homo sapiens_hsa052180.69008365
81Folate biosynthesis_Homo sapiens_hsa007900.68872234
82Dilated cardiomyopathy_Homo sapiens_hsa054140.67675991
83Alzheimers disease_Homo sapiens_hsa050100.67232509
84Basal transcription factors_Homo sapiens_hsa030220.66629145
85Wnt signaling pathway_Homo sapiens_hsa043100.63274692
86Bile secretion_Homo sapiens_hsa049760.63076472
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.62583280
88Basal cell carcinoma_Homo sapiens_hsa052170.61656769
89Collecting duct acid secretion_Homo sapiens_hsa049660.61622055
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59259900
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57335487
92Alcoholism_Homo sapiens_hsa050340.56843641
93RNA degradation_Homo sapiens_hsa030180.55595650
94MicroRNAs in cancer_Homo sapiens_hsa052060.55587488
95Tyrosine metabolism_Homo sapiens_hsa003500.55008925
96Endocytosis_Homo sapiens_hsa041440.53397713
97One carbon pool by folate_Homo sapiens_hsa006700.50981238
98Pathways in cancer_Homo sapiens_hsa052000.50420071
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.50298162
100Mineral absorption_Homo sapiens_hsa049780.49103512
101Hippo signaling pathway_Homo sapiens_hsa043900.49009497
102Tight junction_Homo sapiens_hsa045300.47831589
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47685620
104Glioma_Homo sapiens_hsa052140.47471125
105Colorectal cancer_Homo sapiens_hsa052100.47082708
106mTOR signaling pathway_Homo sapiens_hsa041500.46791795
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45491242
108Selenocompound metabolism_Homo sapiens_hsa004500.44831306
109Homologous recombination_Homo sapiens_hsa034400.44316915
110Ether lipid metabolism_Homo sapiens_hsa005650.43983062
111Phenylalanine metabolism_Homo sapiens_hsa003600.43500130
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43412486
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42257493
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42006260
115VEGF signaling pathway_Homo sapiens_hsa043700.41183213
116Fatty acid biosynthesis_Homo sapiens_hsa000610.40863442
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39881587
118Butanoate metabolism_Homo sapiens_hsa006500.39671611
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38245156
120Pyrimidine metabolism_Homo sapiens_hsa002400.37862455
121Ras signaling pathway_Homo sapiens_hsa040140.37604281
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35857799
123Vibrio cholerae infection_Homo sapiens_hsa051100.34826286
124Rap1 signaling pathway_Homo sapiens_hsa040150.34380684
125Oxidative phosphorylation_Homo sapiens_hsa001900.33784528
126Protein digestion and absorption_Homo sapiens_hsa049740.33666474
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33517240
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33510470
129Fatty acid elongation_Homo sapiens_hsa000620.33313735
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32871313
131Mismatch repair_Homo sapiens_hsa034300.31629966
132Proteoglycans in cancer_Homo sapiens_hsa052050.30056935
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.28821063
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28216161
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27188619
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27132322
137Notch signaling pathway_Homo sapiens_hsa043300.26883115

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