ENAH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.13752541
2regulation of posttranscriptional gene silencing (GO:0060147)3.73571943
3regulation of gene silencing by miRNA (GO:0060964)3.73571943
4regulation of gene silencing by RNA (GO:0060966)3.73571943
5DNA double-strand break processing (GO:0000729)3.51109216
6pre-miRNA processing (GO:0031054)3.49851382
7limb bud formation (GO:0060174)3.48109792
8chromatin remodeling at centromere (GO:0031055)3.38978996
9presynaptic membrane assembly (GO:0097105)3.29142921
10CENP-A containing nucleosome assembly (GO:0034080)3.21971011
11cell migration in hindbrain (GO:0021535)3.07890765
12histone exchange (GO:0043486)3.06318196
13anterior/posterior axis specification, embryo (GO:0008595)3.05735498
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04114402
15pyrimidine nucleobase catabolic process (GO:0006208)3.03005312
16nuclear pore organization (GO:0006999)2.93452258
17nuclear pore complex assembly (GO:0051292)2.87589071
18presynaptic membrane organization (GO:0097090)2.87551962
19notochord development (GO:0030903)2.86278918
20negative regulation of DNA-dependent DNA replication (GO:2000104)2.81467990
21DNA replication-independent nucleosome organization (GO:0034724)2.78913421
22DNA replication-independent nucleosome assembly (GO:0006336)2.78913421
23regulation of hippo signaling (GO:0035330)2.75821443
24protein localization to kinetochore (GO:0034501)2.71738263
25dorsal/ventral axis specification (GO:0009950)2.70599216
26DNA damage response, detection of DNA damage (GO:0042769)2.68850036
27establishment or maintenance of monopolar cell polarity (GO:0061339)2.68166083
28establishment of monopolar cell polarity (GO:0061162)2.68166083
29lateral sprouting from an epithelium (GO:0060601)2.65078835
30metaphase plate congression (GO:0051310)2.62870868
31establishment of apical/basal cell polarity (GO:0035089)2.59866995
32spindle checkpoint (GO:0031577)2.58197225
33replication fork processing (GO:0031297)2.58001237
34DNA replication checkpoint (GO:0000076)2.57577110
35polarized epithelial cell differentiation (GO:0030859)2.56682924
36L-serine metabolic process (GO:0006563)2.55412750
37establishment of integrated proviral latency (GO:0075713)2.51837212
38olfactory bulb development (GO:0021772)2.51113566
39negative regulation of DNA recombination (GO:0045910)2.50305995
40negative regulation of histone methylation (GO:0031061)2.49945580
41regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.49774540
42regulation of mitotic spindle checkpoint (GO:1903504)2.49774540
43regulation of helicase activity (GO:0051095)2.47931046
44negative regulation of axon guidance (GO:1902668)2.47873398
45mitotic spindle checkpoint (GO:0071174)2.46150733
46planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45943661
47sister chromatid segregation (GO:0000819)2.45132368
48layer formation in cerebral cortex (GO:0021819)2.43561015
49hippo signaling (GO:0035329)2.42747049
50axonal fasciculation (GO:0007413)2.41626963
51axon extension involved in axon guidance (GO:0048846)2.41546297
52neuron projection extension involved in neuron projection guidance (GO:1902284)2.41546297
53regulation of short-term neuronal synaptic plasticity (GO:0048172)2.40541489
54histone H4-K12 acetylation (GO:0043983)2.40208697
55regulation of DNA endoreduplication (GO:0032875)2.39877321
56kinetochore organization (GO:0051383)2.38684777
57ventricular cardiac muscle cell development (GO:0055015)2.37673742
58female gonad development (GO:0008585)2.37028333
59negative regulation of mitotic sister chromatid separation (GO:2000816)2.35462256
60negative regulation of sister chromatid segregation (GO:0033046)2.35462256
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.35462256
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.35462256
63negative regulation of mitotic sister chromatid segregation (GO:0033048)2.35462256
64intraciliary transport (GO:0042073)2.33621537
65ATP-dependent chromatin remodeling (GO:0043044)2.33160116
66dendritic spine morphogenesis (GO:0060997)2.31636038
67cell communication by electrical coupling (GO:0010644)2.31320645
68negative regulation of chromosome segregation (GO:0051985)2.31124064
69histone H2A acetylation (GO:0043968)2.31035862
70ganglion development (GO:0061548)2.30866636
71mitotic sister chromatid segregation (GO:0000070)2.30630391
72negative regulation of axon extension involved in axon guidance (GO:0048843)2.30576884
73histone arginine methylation (GO:0034969)2.30298126
74somite development (GO:0061053)2.28278780
75double-strand break repair via nonhomologous end joining (GO:0006303)2.28082330
76non-recombinational repair (GO:0000726)2.28082330
77regulation of centriole replication (GO:0046599)2.27625245
78nucleobase catabolic process (GO:0046113)2.27349781
79lung-associated mesenchyme development (GO:0060484)2.27102639
80positive regulation of SMAD protein import into nucleus (GO:0060391)2.27031303
81regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.24391511
82neuron recognition (GO:0008038)2.24376459
83somatic hypermutation of immunoglobulin genes (GO:0016446)2.23934705
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.23934705
85regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.23504296
86DNA ligation (GO:0006266)2.23399371
87plasma membrane repair (GO:0001778)2.22441481
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.22429142
89establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.21121949
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.20797455
91regulation of mitotic metaphase/anaphase transition (GO:0030071)2.20797455
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.20448839
93artery development (GO:0060840)2.19953366
94kinetochore assembly (GO:0051382)2.19681492
95ectodermal placode formation (GO:0060788)2.19321594
96retinal ganglion cell axon guidance (GO:0031290)2.19037733
97lysine catabolic process (GO:0006554)2.18767601
98lysine metabolic process (GO:0006553)2.18767601
99kidney morphogenesis (GO:0060993)2.18490845
100telomere maintenance via telomerase (GO:0007004)2.18465018
101response to X-ray (GO:0010165)2.18397833
102sympathetic nervous system development (GO:0048485)2.18187305
103innervation (GO:0060384)2.18024642
104regulation of telomere maintenance via telomerase (GO:0032210)2.17755627
105head development (GO:0060322)2.17661801
106histone H4-K5 acetylation (GO:0043981)2.17270884
107histone H4-K8 acetylation (GO:0043982)2.17270884
108negative regulation of DNA repair (GO:0045738)2.17259646
109negative chemotaxis (GO:0050919)2.16948109
110regulation of non-canonical Wnt signaling pathway (GO:2000050)2.16786272
111mitotic spindle organization (GO:0007052)2.16086771
112regulation of mitotic sister chromatid separation (GO:0010965)2.15912475
113regulation of mitotic sister chromatid segregation (GO:0033047)2.15912475
114regulation of sister chromatid segregation (GO:0033045)2.15912475
115negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.15228261
116negative regulation of translation, ncRNA-mediated (GO:0040033)2.15228261
117regulation of translation, ncRNA-mediated (GO:0045974)2.15228261
118establishment of nucleus localization (GO:0040023)2.15213290
119central nervous system projection neuron axonogenesis (GO:0021952)2.15192764
120generation of neurons (GO:0048699)2.15036063
121regulation of chromosome segregation (GO:0051983)2.15008292
122spinal cord development (GO:0021510)2.14821559
123pituitary gland development (GO:0021983)2.12313162
124peptidyl-arginine methylation (GO:0018216)2.08865744
125peptidyl-arginine N-methylation (GO:0035246)2.08865744
126regulation of histone H3-K9 methylation (GO:0051570)2.07931978
127positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.07697523
128negative regulation of organelle assembly (GO:1902116)2.07688057
129neuronal stem cell maintenance (GO:0097150)2.07369312
130neuron cell-cell adhesion (GO:0007158)2.07065059
131DNA replication-dependent nucleosome organization (GO:0034723)2.05453411
132DNA replication-dependent nucleosome assembly (GO:0006335)2.05453411
133peptidyl-arginine omega-N-methylation (GO:0035247)2.04894908
134locomotory exploration behavior (GO:0035641)2.02655380
135convergent extension (GO:0060026)2.02524806
136pore complex assembly (GO:0046931)2.02292751
137apical protein localization (GO:0045176)2.01630844
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.00365708
139cell fate commitment involved in formation of primary germ layer (GO:0060795)2.00299861
140regulation of RNA export from nucleus (GO:0046831)1.99483017
141cerebral cortex development (GO:0021987)1.99481999
142heterochromatin organization (GO:0070828)1.99443102
143nucleus localization (GO:0051647)1.98829097
144regulation of gene expression by genetic imprinting (GO:0006349)1.98685416
145regulation of nuclear cell cycle DNA replication (GO:0033262)1.98622887
146vocalization behavior (GO:0071625)1.98216353
147regulation of gene silencing (GO:0060968)1.96519236
148genetic imprinting (GO:0071514)1.95888186
149gastrulation with mouth forming second (GO:0001702)1.94824003
150mesenchyme development (GO:0060485)1.94655963
151negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.94600892
152negative regulation of potassium ion transmembrane transport (GO:1901380)1.94563572
153regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.94555303
154stress granule assembly (GO:0034063)1.94055701
155spindle assembly involved in mitosis (GO:0090307)1.93743978
156regulation of meiosis I (GO:0060631)1.93550042
157mitotic sister chromatid cohesion (GO:0007064)1.93542189
158intestinal epithelial cell development (GO:0060576)1.92583930
159cell-cell junction maintenance (GO:0045217)1.92492868
160atrial cardiac muscle cell action potential (GO:0086014)1.91913287
161histone H2A monoubiquitination (GO:0035518)1.91474272
162regulation of SMAD protein import into nucleus (GO:0060390)1.91223182
163cell communication involved in cardiac conduction (GO:0086065)1.90258177
164embryonic camera-type eye development (GO:0031076)1.90107526
165cell junction maintenance (GO:0034331)1.88507123
166cerebellar Purkinje cell differentiation (GO:0021702)1.88498339
167mitotic metaphase plate congression (GO:0007080)1.88495797
168microtubule depolymerization (GO:0007019)1.88424584
169regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.87556166
170male sex determination (GO:0030238)1.86763932
171anterior/posterior axis specification (GO:0009948)1.86403312
172cochlea morphogenesis (GO:0090103)1.85984479
173establishment of planar polarity (GO:0001736)1.85959979
174establishment of tissue polarity (GO:0007164)1.85959979
175synaptic vesicle maturation (GO:0016188)1.84844747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.49353014
2EZH2_22144423_ChIP-Seq_EOC_Human3.35094858
3SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.81684215
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.75970613
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.75970613
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.75970613
7E2F7_22180533_ChIP-Seq_HELA_Human2.50543666
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40864784
9SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.29209558
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26671344
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.23646525
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23199644
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21131331
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20713794
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16632983
16* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13481853
17ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.05045027
18TAF15_26573619_Chip-Seq_HEK293_Human2.04294937
19P300_19829295_ChIP-Seq_ESCs_Human2.02230803
20* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.97559200
21* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94451232
22* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.94241257
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.90098276
24IGF1R_20145208_ChIP-Seq_DFB_Human1.85955931
25TCF3_18692474_ChIP-Seq_MESCs_Mouse1.77573890
26AR_21909140_ChIP-Seq_LNCAP_Human1.76747646
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76032021
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74088604
29SOX2_18555785_ChIP-Seq_MESCs_Mouse1.72478535
30GBX2_23144817_ChIP-Seq_PC3_Human1.70993810
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69498216
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.69217567
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66960563
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.66758713
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63837879
36VDR_22108803_ChIP-Seq_LS180_Human1.63803182
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.62343905
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61688764
39* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.58074323
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57136285
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54598219
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.52804816
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52202707
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.49317319
45* ELK1_19687146_ChIP-ChIP_HELA_Human1.49191293
46* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.47652092
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47602998
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47001057
49* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45479437
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45378403
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.44923176
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44885653
53* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43749335
54* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42868432
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42867261
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39835634
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39178155
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38916793
59* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38554320
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37311299
61* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35550201
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35383853
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35175966
64* FUS_26573619_Chip-Seq_HEK293_Human1.32821912
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31193554
66STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31011551
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30435955
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.29092893
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27747103
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25674895
71* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25548945
72* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25271289
73* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25017864
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22971692
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20347165
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.19259523
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18981293
78PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.18647927
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17794452
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17246883
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17184994
82REST_21632747_ChIP-Seq_MESCs_Mouse1.16968727
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16703578
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16703578
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16680717
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14749270
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14749270
88* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.14665550
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14476375
90RNF2_27304074_Chip-Seq_NSC_Mouse1.14255253
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13489331
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.13234582
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.12739282
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11459507
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11449571
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10386428
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09841919
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09513661
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.09298309
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09130526
101* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08928521
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08719502
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08718435
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08505350
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.08336677
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08333238
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06711509
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06356672
109* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06329614
110MYC_18940864_ChIP-ChIP_HL60_Human1.06196754
111AR_25329375_ChIP-Seq_VCAP_Human1.05920333
112* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05705441
113EST1_17652178_ChIP-ChIP_JURKAT_Human1.05574440
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05386915
115* EZH2_27294783_Chip-Seq_NPCs_Mouse1.04749243
116* NANOG_18555785_Chip-Seq_ESCs_Mouse1.04560874
117GATA1_26923725_Chip-Seq_HPCs_Mouse1.04220831
118ZNF274_21170338_ChIP-Seq_K562_Hela1.02706054
119* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02694136
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02627550
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.02313730
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02112770
123PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02062252
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02032960
125CBP_20019798_ChIP-Seq_JUKART_Human1.02032960
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01494961
127JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01063995
128NANOG_21062744_ChIP-ChIP_HESCs_Human1.00743797
129* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00306488
130* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00105756
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99845794
132* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99751060
133RUNX2_22187159_ChIP-Seq_PCA_Human0.98979919
134* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98818446
135BCAT_22108803_ChIP-Seq_LS180_Human0.98669402
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.98501313
137TP53_18474530_ChIP-ChIP_U2OS_Human0.98309778
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97444394
139RARB_27405468_Chip-Seq_BRAIN_Mouse0.97260334
140DROSHA_22980978_ChIP-Seq_HELA_Human0.96648639
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96453878
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94851058
143SMAD4_21799915_ChIP-Seq_A2780_Human0.94616389
144* RING1B_27294783_Chip-Seq_ESCs_Mouse0.94209151
145* NANOG_16518401_ChIP-PET_MESCs_Mouse0.94097263
146* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93826833
147* JUN_21703547_ChIP-Seq_K562_Human0.93255124
148* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93018217
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92578032
150EWS_26573619_Chip-Seq_HEK293_Human0.92293842
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.91214319
152NANOG_16153702_ChIP-ChIP_HESCs_Human0.90866646
153AR_19668381_ChIP-Seq_PC3_Human0.88835989
154SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87805935
155* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87734942
156SOX9_26525672_Chip-Seq_HEART_Mouse0.86872939
157STAT3_23295773_ChIP-Seq_U87_Human0.86004989
158CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85841141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology2.02338263
2MP0002653_abnormal_ependyma_morphology2.01791616
3MP0003123_paternal_imprinting1.99210407
4MP0010030_abnormal_orbit_morphology1.92435721
5MP0003941_abnormal_skin_development1.88104035
6MP0003121_genomic_imprinting1.87722783
7MP0004859_abnormal_synaptic_plasticity1.76978288
8MP0003283_abnormal_digestive_organ1.75117855
9MP0003880_abnormal_central_pattern1.73982541
10MP0004133_heterotaxia1.70350883
11MP0003787_abnormal_imprinting1.67504296
12MP0003122_maternal_imprinting1.67471325
13MP0003119_abnormal_digestive_system1.63599477
14MP0001188_hyperpigmentation1.61816082
15MP0004270_analgesia1.60241385
16* MP0000778_abnormal_nervous_system1.59531532
17MP0001529_abnormal_vocalization1.53197685
18MP0002234_abnormal_pharynx_morphology1.52858954
19MP0003937_abnormal_limbs/digits/tail_de1.50206737
20MP0003890_abnormal_embryonic-extraembry1.49072228
21MP0006292_abnormal_olfactory_placode1.47380949
22MP0000537_abnormal_urethra_morphology1.46461907
23MP0001485_abnormal_pinna_reflex1.44947008
24MP0008877_abnormal_DNA_methylation1.41505009
25MP0003693_abnormal_embryo_hatching1.41366128
26MP0000579_abnormal_nail_morphology1.40484312
27MP0003755_abnormal_palate_morphology1.36125604
28MP0002084_abnormal_developmental_patter1.35823430
29MP0003111_abnormal_nucleus_morphology1.34904205
30* MP0003861_abnormal_nervous_system1.34373341
31MP0001293_anophthalmia1.34182580
32MP0000049_abnormal_middle_ear1.33823206
33MP0005394_taste/olfaction_phenotype1.33450162
34MP0005499_abnormal_olfactory_system1.33450162
35MP0000751_myopathy1.32060932
36MP0001177_atelectasis1.31683779
37MP0003136_yellow_coat_color1.31223796
38MP0008789_abnormal_olfactory_epithelium1.30680200
39MP0004233_abnormal_muscle_weight1.26875171
40MP0004885_abnormal_endolymph1.26703970
41MP0006072_abnormal_retinal_apoptosis1.26129770
42MP0005377_hearing/vestibular/ear_phenot1.24710622
43MP0003878_abnormal_ear_physiology1.24710622
44MP0005367_renal/urinary_system_phenotyp1.24232024
45MP0000516_abnormal_urinary_system1.24232024
46MP0003385_abnormal_body_wall1.23969193
47MP0001299_abnormal_eye_distance/1.23566944
48MP0000566_synostosis1.23327175
49* MP0002085_abnormal_embryonic_tissue1.22666679
50MP0000534_abnormal_ureter_morphology1.22190975
51MP0002736_abnormal_nociception_after1.20380666
52MP0002249_abnormal_larynx_morphology1.20344501
53MP0003635_abnormal_synaptic_transmissio1.20225262
54MP0002233_abnormal_nose_morphology1.19075507
55MP0008057_abnormal_DNA_replication1.18728823
56MP0001486_abnormal_startle_reflex1.18569981
57MP0000428_abnormal_craniofacial_morphol1.16992618
58MP0002282_abnormal_trachea_morphology1.16877384
59MP0000647_abnormal_sebaceous_gland1.15918031
60MP0004084_abnormal_cardiac_muscle1.15432572
61MP0003935_abnormal_craniofacial_develop1.14423010
62MP0001984_abnormal_olfaction1.13658233
63MP0002184_abnormal_innervation1.13090923
64MP0004858_abnormal_nervous_system1.12997285
65MP0005171_absent_coat_pigmentation1.12416782
66MP0003718_maternal_effect1.11742618
67MP0004215_abnormal_myocardial_fiber1.11468651
68MP0004145_abnormal_muscle_electrophysio1.07797719
69MP0003942_abnormal_urinary_system1.06677092
70MP0002734_abnormal_mechanical_nocicepti1.06531932
71MP0009672_abnormal_birth_weight1.06334167
72MP0003137_abnormal_impulse_conducting1.06087587
73MP0004197_abnormal_fetal_growth/weight/1.05655382
74MP0000762_abnormal_tongue_morphology1.04653018
75MP0009053_abnormal_anal_canal1.04529122
76MP0005423_abnormal_somatic_nervous1.04399742
77MP0000955_abnormal_spinal_cord1.04054020
78MP0002116_abnormal_craniofacial_bone1.03845638
79MP0002063_abnormal_learning/memory/cond1.03577592
80MP0010094_abnormal_chromosome_stability1.03367236
81MP0002092_abnormal_eye_morphology1.03143953
82MP0004957_abnormal_blastocyst_morpholog1.02845333
83MP0000432_abnormal_head_morphology1.00954761
84MP0004272_abnormal_basement_membrane1.00613564
85* MP0002152_abnormal_brain_morphology1.00142143
86MP0009697_abnormal_copulation1.00024380
87MP0001286_abnormal_eye_development0.99075393
88MP0003567_abnormal_fetal_cardiomyocyte0.98465965
89MP0009250_abnormal_appendicular_skeleto0.98333682
90MP0005391_vision/eye_phenotype0.98194712
91MP0008007_abnormal_cellular_replicative0.97987627
92MP0000631_abnormal_neuroendocrine_gland0.94813421
93MP0001672_abnormal_embryogenesis/_devel0.94625774
94MP0005380_embryogenesis_phenotype0.94625774
95MP0002697_abnormal_eye_size0.94540118
96MP0009703_decreased_birth_body0.93773008
97MP0008058_abnormal_DNA_repair0.92557780
98MP0003938_abnormal_ear_development0.92520228
99MP0008932_abnormal_embryonic_tissue0.92339320
100MP0005187_abnormal_penis_morphology0.92211562
101MP0009046_muscle_twitch0.91361484
102MP0000569_abnormal_digit_pigmentation0.90806420
103MP0003315_abnormal_perineum_morphology0.90076279
104MP0002127_abnormal_cardiovascular_syste0.89517219
105* MP0002882_abnormal_neuron_morphology0.89310230
106MP0005248_abnormal_Harderian_gland0.89279492
107MP0002751_abnormal_autonomic_nervous0.88987450
108MP0005253_abnormal_eye_physiology0.88270030
109MP0002114_abnormal_axial_skeleton0.88201984
110MP0006276_abnormal_autonomic_nervous0.87280430
111MP0001849_ear_inflammation0.85191167
112MP0002752_abnormal_somatic_nervous0.85120742
113MP0002938_white_spotting0.84955311
114* MP0002081_perinatal_lethality0.84621281
115MP0003077_abnormal_cell_cycle0.84586341
116MP0005076_abnormal_cell_differentiation0.84085004
117MP0001730_embryonic_growth_arrest0.83747074
118MP0002111_abnormal_tail_morphology0.83631146
119MP0010352_gastrointestinal_tract_polyps0.82771161
120MP0002572_abnormal_emotion/affect_behav0.82240037
121MP0000026_abnormal_inner_ear0.82187309
122MP0002177_abnormal_outer_ear0.78109245
123MP0001346_abnormal_lacrimal_gland0.76249100
124MP0002254_reproductive_system_inflammat0.74650683
125MP0002109_abnormal_limb_morphology0.74117364
126MP0006054_spinal_hemorrhage0.73985288

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.46688150
2Volvulus (HP:0002580)2.80633510
3Ependymoma (HP:0002888)2.63699574
4Astrocytoma (HP:0009592)2.59718121
5Abnormality of the astrocytes (HP:0100707)2.59718121
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49330204
7Abnormal lung lobation (HP:0002101)2.44168977
8Cortical dysplasia (HP:0002539)2.42880792
9Intestinal atresia (HP:0011100)2.42596093
10Glioma (HP:0009733)2.38044185
11Neoplasm of the oral cavity (HP:0100649)2.27569719
12Meckel diverticulum (HP:0002245)2.17070608
13Supernumerary spleens (HP:0009799)2.16066503
14Hypoplastic ischia (HP:0003175)2.14487932
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.08878432
16Abnormality of the ileum (HP:0001549)2.08717219
17Shawl scrotum (HP:0000049)2.07007001
18Drooling (HP:0002307)2.03277661
19Rib fusion (HP:0000902)2.02205837
20Genital tract atresia (HP:0001827)1.99518754
21Renal hypoplasia (HP:0000089)1.98743980
22Medulloblastoma (HP:0002885)1.98710497
23Labial hypoplasia (HP:0000066)1.97423018
24True hermaphroditism (HP:0010459)1.96118463
25Vaginal atresia (HP:0000148)1.95904162
26Hypoplastic female external genitalia (HP:0012815)1.94174645
27Abnormality of chromosome stability (HP:0003220)1.93037090
28Supernumerary ribs (HP:0005815)1.92478495
29Absent radius (HP:0003974)1.91938169
30Aplasia involving forearm bones (HP:0009822)1.91633347
31Absent forearm bone (HP:0003953)1.91633347
32Aplasia/Hypoplasia of the sternum (HP:0006714)1.91130119
33Pancreatic fibrosis (HP:0100732)1.88978699
34Ectopic kidney (HP:0000086)1.88377286
35Anophthalmia (HP:0000528)1.87569528
36Abnormality of the ischium (HP:0003174)1.86561680
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86373829
38Short 4th metacarpal (HP:0010044)1.86373829
39Stenosis of the external auditory canal (HP:0000402)1.85193764
40Rhabdomyosarcoma (HP:0002859)1.84926606
41Aqueductal stenosis (HP:0002410)1.82775820
42Abnormality of the pubic bones (HP:0003172)1.82725168
43Papillary thyroid carcinoma (HP:0002895)1.81587360
44Optic nerve hypoplasia (HP:0000609)1.81420972
45Preaxial hand polydactyly (HP:0001177)1.81196340
46Supernumerary bones of the axial skeleton (HP:0009144)1.80977264
47Pancreatic cysts (HP:0001737)1.79932913
48Aplasia/hypoplasia of the humerus (HP:0006507)1.79842157
49Embryonal renal neoplasm (HP:0011794)1.79815775
50Hip contracture (HP:0003273)1.78764806
51Short humerus (HP:0005792)1.78106697
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77807837
53Missing ribs (HP:0000921)1.77682129
54Cutaneous finger syndactyly (HP:0010554)1.77170651
55Hepatoblastoma (HP:0002884)1.76587939
56Abdominal situs inversus (HP:0003363)1.75453939
57Abnormality of abdominal situs (HP:0011620)1.75453939
58Short 1st metacarpal (HP:0010034)1.75184926
59Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75184926
60Esophageal atresia (HP:0002032)1.74942135
61Absent septum pellucidum (HP:0001331)1.73942896
62Molar tooth sign on MRI (HP:0002419)1.73875614
63Abnormality of midbrain morphology (HP:0002418)1.73875614
64Dandy-Walker malformation (HP:0001305)1.73567742
65Nephronophthisis (HP:0000090)1.72040437
66Excessive salivation (HP:0003781)1.70710043
67Myelomeningocele (HP:0002475)1.70027739
68Abnormality of the duodenum (HP:0002246)1.69898944
69Triphalangeal thumb (HP:0001199)1.69536702
70Abnormality of the septum pellucidum (HP:0007375)1.69412849
71Scrotal hypoplasia (HP:0000046)1.67938465
72Oligodactyly (hands) (HP:0001180)1.67436083
73Postaxial hand polydactyly (HP:0001162)1.66521252
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.66082796
75Limited hip movement (HP:0008800)1.65425573
76Small hand (HP:0200055)1.64588884
77Micropenis (HP:0000054)1.63280006
78Shallow orbits (HP:0000586)1.62971792
79Renal duplication (HP:0000075)1.61541514
80Duodenal stenosis (HP:0100867)1.61458787
81Small intestinal stenosis (HP:0012848)1.61458787
82Cutaneous syndactyly (HP:0012725)1.61439537
83Abnormal number of incisors (HP:0011064)1.61288661
84Oligodactyly (HP:0012165)1.60394477
85Coronal craniosynostosis (HP:0004440)1.60003924
86Shoulder girdle muscle weakness (HP:0003547)1.58954380
87Neoplasm of the adrenal cortex (HP:0100641)1.58561856
88Anal stenosis (HP:0002025)1.57721180
89Broad thumb (HP:0011304)1.57327481
90Exotropia (HP:0000577)1.57080384
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.56984374
92Narrow forehead (HP:0000341)1.56635203
93Abnormality of the antihelix (HP:0009738)1.56311372
94Sudden death (HP:0001699)1.56215207
95Fibular aplasia (HP:0002990)1.53940523
96High anterior hairline (HP:0009890)1.53930930
97Birth length less than 3rd percentile (HP:0003561)1.53708533
98Decreased lacrimation (HP:0000633)1.53697407
99Colon cancer (HP:0003003)1.53546677
100Genetic anticipation (HP:0003743)1.53168772
101Septo-optic dysplasia (HP:0100842)1.52706883
102Anencephaly (HP:0002323)1.52638538
103Medial flaring of the eyebrow (HP:0010747)1.52411833
104Gait imbalance (HP:0002141)1.52091550
105Patellar aplasia (HP:0006443)1.52089640
106Hyperglycinemia (HP:0002154)1.51782830
107Aplasia involving bones of the extremities (HP:0009825)1.51747000
108Aplasia involving bones of the upper limbs (HP:0009823)1.51747000
109Aplasia of the phalanges of the hand (HP:0009802)1.51747000
110Focal motor seizures (HP:0011153)1.51629692
111Bilateral microphthalmos (HP:0007633)1.51188347
112Abnormality of the lower motor neuron (HP:0002366)1.50871439
113Hypoplastic pelvis (HP:0008839)1.50223410
114Postaxial foot polydactyly (HP:0001830)1.50026865
115Midline defect of the nose (HP:0004122)1.49660309
116Alacrima (HP:0000522)1.49420395
117Long clavicles (HP:0000890)1.49194855
118Congenital primary aphakia (HP:0007707)1.49001721
119Synostosis of carpal bones (HP:0005048)1.48821911
120Sloping forehead (HP:0000340)1.48032673
121Abnormality of the diencephalon (HP:0010662)1.47968646
122Hypoplastic labia majora (HP:0000059)1.47795849
123Chromsome breakage (HP:0040012)1.47594636
124Preaxial foot polydactyly (HP:0001841)1.47444579
125Short phalanx of the thumb (HP:0009660)1.47079322
126Aplasia/Hypoplasia of the patella (HP:0006498)1.44893842
127Cupped ear (HP:0000378)1.44019016
128Neoplasm of striated muscle (HP:0009728)1.42389471
129Morphological abnormality of the middle ear (HP:0008609)1.42188244
130Skull defect (HP:0001362)1.41828713
131Focal seizures (HP:0007359)1.41771303
132Facial hemangioma (HP:0000329)1.41605336
133Abnormality of the nasal septum (HP:0000419)1.41000745
134Abnormality of the 1st metacarpal (HP:0010009)1.40615309
135Maternal diabetes (HP:0009800)1.40090242
136Gastrointestinal atresia (HP:0002589)1.39520470
137Ectopic anus (HP:0004397)1.39225419
138Facial cleft (HP:0002006)1.39117740
139Hemivertebrae (HP:0002937)1.39067901
140Abnormality of the labia majora (HP:0012881)1.38964689
141Pelvic girdle muscle weakness (HP:0003749)1.38658150
142Spina bifida occulta (HP:0003298)1.38559568
143Sex reversal (HP:0012245)1.38533795
144Abnormal sex determination (HP:0012244)1.38533795
145Selective tooth agenesis (HP:0001592)1.36918402
146Omphalocele (HP:0001539)1.36660801
147Abnormality of the 4th metacarpal (HP:0010012)1.36572986
148Progressive cerebellar ataxia (HP:0002073)1.36563938
149Vertebral fusion (HP:0002948)1.36104593
150Nephroblastoma (Wilms tumor) (HP:0002667)1.35759982
151Abnormality of the labia (HP:0000058)1.35563996
152Increased nuchal translucency (HP:0010880)1.35467093
153Bifid tongue (HP:0010297)1.35463696
154Broad finger (HP:0001500)1.34860080
155Absent eyebrow (HP:0002223)1.34799282
156Broad phalanges of the hand (HP:0009768)1.34781768
157Cystic hygroma (HP:0000476)1.34320614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.61443457
2TNIK3.33226195
3TRIM283.00198995
4CDK122.83520539
5MARK12.80221995
6LATS22.60697549
7AKT32.39647776
8EPHA22.36300726
9BUB12.25734123
10NTRK32.24754006
11LATS12.14910691
12MAP3K41.88252348
13BRD41.86660136
14STK38L1.84798522
15DDR21.84055089
16NUAK11.82291333
17BRSK21.74765497
18MAP3K91.73499947
19SRPK11.72562378
20BMPR1B1.71245992
21ZAK1.64688185
22NEK11.63644807
23TTK1.63615771
24CDC71.51286380
25PRKD31.43996427
26EPHA41.40633787
27PBK1.38169000
28PLK31.35440403
29NTRK21.32484771
30MKNK21.30090105
31STK381.29965029
32PHKG21.28753502
33PHKG11.28753502
34ICK1.28653349
35WEE11.24661224
36PAK61.22229849
37ACVR1B1.21868205
38MINK11.19191892
39TAF11.17794597
40KSR11.17107491
41ERBB31.17037813
42ALK1.16880780
43FRK1.16575515
44CSNK1G11.14987573
45FGFR21.09387369
46TYRO31.09149852
47WNK31.08850975
48LMTK21.08833519
49MAPK131.08471391
50CSNK1G21.08371635
51EIF2AK31.08234437
52BCR1.08137141
53CHEK21.07827493
54MKNK11.04265938
55CDC42BPA1.00536630
56MAP4K20.99983363
57DYRK20.97090549
58PAK30.95046330
59DMPK0.94510470
60STK390.93453978
61OBSCN0.92300355
62CSNK1E0.88102299
63FER0.87818331
64PLK10.87394222
65TSSK60.87076248
66CSNK1G30.86444405
67BRSK10.85944627
68PLK20.85663464
69CHEK10.84778147
70PRKCI0.84630601
71PDGFRA0.84178173
72EIF2AK10.82636759
73VRK10.80453354
74MTOR0.79168082
75EPHB20.78219340
76UHMK10.76473638
77ATM0.75086751
78DYRK30.74822993
79TGFBR10.74654115
80FGFR10.73906915
81WNK10.72765644
82CSNK1D0.72204320
83CDK20.70708579
84CAMK1G0.70254018
85MAP2K70.68402982
86CDK10.66636512
87ATR0.65006774
88CASK0.64861792
89VRK20.64048047
90RPS6KB20.63601528
91MAPK100.63491816
92GSK3B0.62275301
93PRKCE0.61426619
94ROCK10.61145869
95MST40.59828609
96AURKA0.59364214
97DYRK1A0.59082121
98CDK70.58734617
99AKT20.57261312
100TTN0.56462066
101GRK10.56318775
102EIF2AK20.55692064
103SIK30.55689444
104PLK40.54699306
105RPS6KA40.53901554
106SGK20.52258458
107* PRKDC0.51974013
108NEK20.51840806
109PKN10.51507850
110OXSR10.50976442
111NEK60.50552399
112MAPK140.49458904
113NTRK10.48738143
114CSNK1A1L0.47496365
115MET0.46137703
116PRKCG0.45626761
117STK110.45470829
118CAMK2A0.45422695
119PDK40.45361676
120PDK30.45361676
121MAPK80.43178260
122CDK30.42936531
123CDK140.42568319
124YES10.42479039
125ERBB40.42367617
126MAP2K40.41494553
127CDK50.41399383
128PAK20.41277609
129CDK180.41251741
130AURKB0.41087459
131CDK150.40507458
132STK30.40140215
133ROCK20.39390268
134STK240.38989614
135SGK2230.38951991
136SGK4940.38951991
137NLK0.37729923
138STK160.35958970
139FLT30.33367699

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.21002437
2Protein export_Homo sapiens_hsa030602.20836945
3Basal cell carcinoma_Homo sapiens_hsa052172.10091336
4Steroid biosynthesis_Homo sapiens_hsa001002.05916242
5Hedgehog signaling pathway_Homo sapiens_hsa043402.03628488
6Hippo signaling pathway_Homo sapiens_hsa043902.03290211
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00101225
8Propanoate metabolism_Homo sapiens_hsa006401.99370999
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97854895
10mRNA surveillance pathway_Homo sapiens_hsa030151.86025174
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.77563040
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75769116
13RNA transport_Homo sapiens_hsa030131.69969447
14DNA replication_Homo sapiens_hsa030301.69498996
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69421138
16Vitamin B6 metabolism_Homo sapiens_hsa007501.64373504
17Dilated cardiomyopathy_Homo sapiens_hsa054141.57378016
18Wnt signaling pathway_Homo sapiens_hsa043101.56693550
19Oocyte meiosis_Homo sapiens_hsa041141.52430773
20Axon guidance_Homo sapiens_hsa043601.52291040
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.52061746
22Tight junction_Homo sapiens_hsa045301.48205857
23Selenocompound metabolism_Homo sapiens_hsa004501.48085105
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42191997
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.41720715
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40935683
27Long-term potentiation_Homo sapiens_hsa047201.40153081
28Synaptic vesicle cycle_Homo sapiens_hsa047211.39637481
29Proteasome_Homo sapiens_hsa030501.39577372
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38515815
31Adherens junction_Homo sapiens_hsa045201.38436156
32Mismatch repair_Homo sapiens_hsa034301.35916753
33Taste transduction_Homo sapiens_hsa047421.35327076
34Cell cycle_Homo sapiens_hsa041101.34563742
35Amphetamine addiction_Homo sapiens_hsa050311.34120801
36Melanogenesis_Homo sapiens_hsa049161.32866926
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31882872
38Circadian entrainment_Homo sapiens_hsa047131.31642888
39Spliceosome_Homo sapiens_hsa030401.29863390
40GABAergic synapse_Homo sapiens_hsa047271.29664567
41Insulin secretion_Homo sapiens_hsa049111.28794408
42TGF-beta signaling pathway_Homo sapiens_hsa043501.27813485
43Dopaminergic synapse_Homo sapiens_hsa047281.27096625
44Glutamatergic synapse_Homo sapiens_hsa047241.27009821
45Cardiac muscle contraction_Homo sapiens_hsa042601.25143971
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24961722
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21577665
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18802851
49Base excision repair_Homo sapiens_hsa034101.18323155
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18303876
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18181014
52Pyruvate metabolism_Homo sapiens_hsa006201.17991836
53Olfactory transduction_Homo sapiens_hsa047401.17505574
54Fanconi anemia pathway_Homo sapiens_hsa034601.17038195
55Dorso-ventral axis formation_Homo sapiens_hsa043201.11513221
56MicroRNAs in cancer_Homo sapiens_hsa052061.10446623
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09906326
58mTOR signaling pathway_Homo sapiens_hsa041501.06536151
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06217003
60Gap junction_Homo sapiens_hsa045401.05561453
61ErbB signaling pathway_Homo sapiens_hsa040121.05282303
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04042088
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03995887
64Morphine addiction_Homo sapiens_hsa050321.03606843
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03276729
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02865747
67One carbon pool by folate_Homo sapiens_hsa006701.00695035
68Nucleotide excision repair_Homo sapiens_hsa034201.00671468
69Basal transcription factors_Homo sapiens_hsa030220.99789043
70Estrogen signaling pathway_Homo sapiens_hsa049150.98803445
71Cholinergic synapse_Homo sapiens_hsa047250.98306306
72Serotonergic synapse_Homo sapiens_hsa047260.97762436
73Alcoholism_Homo sapiens_hsa050340.97598445
74Oxytocin signaling pathway_Homo sapiens_hsa049210.97316864
75Melanoma_Homo sapiens_hsa052180.97010053
76RNA polymerase_Homo sapiens_hsa030200.96024780
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95880509
78Notch signaling pathway_Homo sapiens_hsa043300.95693701
79Gastric acid secretion_Homo sapiens_hsa049710.95693077
80Long-term depression_Homo sapiens_hsa047300.95604135
81Butanoate metabolism_Homo sapiens_hsa006500.95077611
82Colorectal cancer_Homo sapiens_hsa052100.94389608
83Endometrial cancer_Homo sapiens_hsa052130.92144093
84GnRH signaling pathway_Homo sapiens_hsa049120.91567579
85Lysine degradation_Homo sapiens_hsa003100.91347926
86Calcium signaling pathway_Homo sapiens_hsa040200.90637931
87Cocaine addiction_Homo sapiens_hsa050300.90432801
88ECM-receptor interaction_Homo sapiens_hsa045120.89926415
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89319119
90Salivary secretion_Homo sapiens_hsa049700.86158485
91Phototransduction_Homo sapiens_hsa047440.83873570
92Type II diabetes mellitus_Homo sapiens_hsa049300.83483240
93Fatty acid elongation_Homo sapiens_hsa000620.83419212
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83064559
95Glioma_Homo sapiens_hsa052140.82976508
96cAMP signaling pathway_Homo sapiens_hsa040240.82311508
97Renal cell carcinoma_Homo sapiens_hsa052110.81062171
98Proteoglycans in cancer_Homo sapiens_hsa052050.80799180
99Focal adhesion_Homo sapiens_hsa045100.79925238
100RNA degradation_Homo sapiens_hsa030180.79168342
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78977010
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77165408
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75418619
104Pathways in cancer_Homo sapiens_hsa052000.74490980
105Circadian rhythm_Homo sapiens_hsa047100.74049297
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73979300
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73915405
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73872344
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73586930
110Rap1 signaling pathway_Homo sapiens_hsa040150.72079261
111Renin secretion_Homo sapiens_hsa049240.71668431
112Biosynthesis of amino acids_Homo sapiens_hsa012300.69996347
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69890338
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69421987
115Homologous recombination_Homo sapiens_hsa034400.69073752
116MAPK signaling pathway_Homo sapiens_hsa040100.67910644
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64881773
118p53 signaling pathway_Homo sapiens_hsa041150.64522020
119beta-Alanine metabolism_Homo sapiens_hsa004100.64440321
120Purine metabolism_Homo sapiens_hsa002300.64024693
121Prostate cancer_Homo sapiens_hsa052150.63478330
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62987939
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62564818
124Choline metabolism in cancer_Homo sapiens_hsa052310.62300133
125Pyrimidine metabolism_Homo sapiens_hsa002400.61700559
126Glucagon signaling pathway_Homo sapiens_hsa049220.61352698
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.61329162
128* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61050194
129Non-homologous end-joining_Homo sapiens_hsa034500.60975446
130Ras signaling pathway_Homo sapiens_hsa040140.60104528
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59670950
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.58088946
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57407191
134Fatty acid metabolism_Homo sapiens_hsa012120.57228096
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55214999
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51201343
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49636650
138Huntingtons disease_Homo sapiens_hsa050160.49531569
139Arginine and proline metabolism_Homo sapiens_hsa003300.47291263
140Carbon metabolism_Homo sapiens_hsa012000.45895525
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45593473
142Nitrogen metabolism_Homo sapiens_hsa009100.43242914
143Glutathione metabolism_Homo sapiens_hsa004800.40338248
144Retinol metabolism_Homo sapiens_hsa008300.38665396
145Metabolic pathways_Homo sapiens_hsa011000.36523708
146Fatty acid degradation_Homo sapiens_hsa000710.34619691
147Caffeine metabolism_Homo sapiens_hsa002320.34578102
148Protein digestion and absorption_Homo sapiens_hsa049740.34243775

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