ENC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.45111545
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.84562261
3vocalization behavior (GO:0071625)5.72967697
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.57353921
5neurotransmitter-gated ion channel clustering (GO:0072578)5.49361519
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.37881070
7glutamate secretion (GO:0014047)5.15588810
8regulation of glutamate receptor signaling pathway (GO:1900449)5.15411263
9neuron cell-cell adhesion (GO:0007158)5.14869211
10synaptic vesicle exocytosis (GO:0016079)5.12338562
11protein localization to synapse (GO:0035418)4.92575859
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.88446519
13postsynaptic membrane organization (GO:0001941)4.83480832
14regulation of synaptic vesicle exocytosis (GO:2000300)4.81624234
15synaptic vesicle maturation (GO:0016188)4.81329161
16presynaptic membrane assembly (GO:0097105)4.78411139
17cellular potassium ion homeostasis (GO:0030007)4.68296495
18locomotory exploration behavior (GO:0035641)4.54215371
19sodium ion export (GO:0071436)4.49882792
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.43086336
21positive regulation of dendritic spine morphogenesis (GO:0061003)4.42533824
22regulation of synaptic vesicle transport (GO:1902803)4.30276730
23presynaptic membrane organization (GO:0097090)4.29517140
24synaptic transmission, glutamatergic (GO:0035249)4.24115547
25exploration behavior (GO:0035640)4.09831098
26neuron recognition (GO:0008038)4.02984471
27axonal fasciculation (GO:0007413)4.00458823
28L-amino acid import (GO:0043092)3.98445178
29regulation of neuronal synaptic plasticity (GO:0048168)3.98236712
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95700784
31glutamate receptor signaling pathway (GO:0007215)3.94876577
32limb bud formation (GO:0060174)3.93334653
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91619417
34long-term synaptic potentiation (GO:0060291)3.90888924
35neuron-neuron synaptic transmission (GO:0007270)3.85850072
36positive regulation of synapse maturation (GO:0090129)3.85551781
37positive regulation of dendritic spine development (GO:0060999)3.81797284
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.79895487
39amino acid import (GO:0043090)3.79092165
40cerebral cortex radially oriented cell migration (GO:0021799)3.77661449
41neurotransmitter secretion (GO:0007269)3.70136125
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66089704
43dendritic spine morphogenesis (GO:0060997)3.65965069
44neuronal ion channel clustering (GO:0045161)3.65343862
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64348171
46regulation of synaptic plasticity (GO:0048167)3.64109837
47regulation of postsynaptic membrane potential (GO:0060078)3.59373765
48positive regulation of membrane potential (GO:0045838)3.59005493
49positive regulation of neurotransmitter secretion (GO:0001956)3.58587770
50neuromuscular process controlling balance (GO:0050885)3.57746914
51regulation of dendritic spine morphogenesis (GO:0061001)3.57698099
52cerebellar granule cell differentiation (GO:0021707)3.52989001
53pyrimidine nucleobase catabolic process (GO:0006208)3.52488015
54regulation of synapse structural plasticity (GO:0051823)3.52037965
55central nervous system projection neuron axonogenesis (GO:0021952)3.51427247
56synapse assembly (GO:0007416)3.51245664
57regulation of neurotransmitter secretion (GO:0046928)3.48492845
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47618007
59dendrite morphogenesis (GO:0048813)3.39642590
60gamma-aminobutyric acid transport (GO:0015812)3.35814266
61regulation of synapse maturation (GO:0090128)3.32838440
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30877689
63layer formation in cerebral cortex (GO:0021819)3.29393430
64cerebellar Purkinje cell differentiation (GO:0021702)3.28718435
65negative regulation of dendrite morphogenesis (GO:0050774)3.28140145
66negative regulation of dendrite development (GO:2000171)3.27352114
67regulation of voltage-gated calcium channel activity (GO:1901385)3.25900528
68dendrite development (GO:0016358)3.25825763
69regulation of neurotransmitter levels (GO:0001505)3.24882874
70cell communication by electrical coupling (GO:0010644)3.23125828
71startle response (GO:0001964)3.21484580
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19852844
73G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.19719885
74establishment of mitochondrion localization (GO:0051654)3.18747079
75transmission of nerve impulse (GO:0019226)3.17385115
76long-term memory (GO:0007616)3.12952844
77regulation of neurotransmitter transport (GO:0051588)3.12789633
78regulation of dendrite morphogenesis (GO:0048814)3.12627044
79proline transport (GO:0015824)3.11269803
80long term synaptic depression (GO:0060292)3.10938995
81membrane depolarization during action potential (GO:0086010)3.10904515
82synaptic vesicle endocytosis (GO:0048488)3.10349586
83membrane depolarization (GO:0051899)3.09442203
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.08376669
85axon extension (GO:0048675)3.08194813
86positive regulation of synapse assembly (GO:0051965)3.07272375
87regulation of dendritic spine development (GO:0060998)3.07029549
88potassium ion homeostasis (GO:0055075)3.06785878
89positive regulation of neurotransmitter transport (GO:0051590)3.06376574
90cellular sodium ion homeostasis (GO:0006883)3.06087097
91neuromuscular synaptic transmission (GO:0007274)3.05939383
92central nervous system myelination (GO:0022010)3.05770515
93axon ensheathment in central nervous system (GO:0032291)3.05770515
94cell migration in hindbrain (GO:0021535)3.03590814
95regulation of female receptivity (GO:0045924)3.02788567
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02010888
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00467573
98response to auditory stimulus (GO:0010996)2.99850504
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98921836
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.98822709
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.95194867
102auditory behavior (GO:0031223)2.94506302
103positive regulation of synaptic transmission (GO:0050806)2.94302780
104innervation (GO:0060384)2.93863249
105neuromuscular process (GO:0050905)2.91896905
106nucleobase catabolic process (GO:0046113)2.90744191
107positive regulation of dendrite development (GO:1900006)2.90011138
108regulation of dendrite development (GO:0050773)2.89403082
109regulation of respiratory system process (GO:0044065)2.89353573
110learning (GO:0007612)2.89284515
111neuronal action potential propagation (GO:0019227)2.88381703
112regulation of glutamate secretion (GO:0014048)2.88268867
113regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.87876989
114regulation of ARF protein signal transduction (GO:0032012)2.87460518
115calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.86845578
116regulation of synapse assembly (GO:0051963)2.86543598
117G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85961760
118regulation of synaptic transmission (GO:0050804)2.83938441
119synapse organization (GO:0050808)2.83723473
120regulation of synapse organization (GO:0050807)2.81238008
121response to histamine (GO:0034776)2.81154396
122dendritic spine organization (GO:0097061)2.80711660
123regulation of vesicle fusion (GO:0031338)2.80283026
124mechanosensory behavior (GO:0007638)2.80278848
125cochlea development (GO:0090102)2.79747048
126vesicle transport along microtubule (GO:0047496)2.79293295
127behavioral fear response (GO:0001662)2.78885220
128behavioral defense response (GO:0002209)2.78885220
129neurotransmitter transport (GO:0006836)2.78497273
130female mating behavior (GO:0060180)2.78162222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.23381377
2GBX2_23144817_ChIP-Seq_PC3_Human4.23399300
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04822177
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82797725
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72753338
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.62821646
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58619431
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51643314
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50916821
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50916821
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.49445137
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.45751555
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44481754
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43282232
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41374120
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.38975045
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38955135
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30192933
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.20818026
20AR_21572438_ChIP-Seq_LNCaP_Human2.16817892
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16296123
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.15718040
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14536583
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12657482
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10751120
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.01492028
27DROSHA_22980978_ChIP-Seq_HELA_Human1.95912942
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93738271
29* REST_18959480_ChIP-ChIP_MESCs_Mouse1.91787423
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87563681
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85970622
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84014973
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80828494
34SMAD4_21799915_ChIP-Seq_A2780_Human1.78814538
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77664614
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74942581
37* P300_19829295_ChIP-Seq_ESCs_Human1.72804561
38* SMAD3_21741376_ChIP-Seq_EPCs_Human1.64449592
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64214332
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.62894867
41TAF15_26573619_Chip-Seq_HEK293_Human1.61735235
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60918505
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60770152
44* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56043103
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54686429
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50798485
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48014644
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47376989
49RNF2_27304074_Chip-Seq_NSC_Mouse1.44994454
50AR_25329375_ChIP-Seq_VCAP_Human1.44663711
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.42043477
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41710345
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39940830
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38125465
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35846375
56FUS_26573619_Chip-Seq_HEK293_Human1.32584683
57* TP53_18474530_ChIP-ChIP_U2OS_Human1.30449557
58* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30064287
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28817040
60ZNF274_21170338_ChIP-Seq_K562_Hela1.27711933
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.27546377
62* KDM2B_26808549_Chip-Seq_K562_Human1.27232317
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27091226
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27091226
65* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26196308
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.25741500
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24934109
68* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24650048
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24626846
70STAT3_23295773_ChIP-Seq_U87_Human1.23354984
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23308326
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23205638
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22350480
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.21932219
75TCF4_23295773_ChIP-Seq_U87_Human1.21723727
76* RING1B_27294783_Chip-Seq_NPCs_Mouse1.21436717
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.21240814
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20160246
79* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19324282
80ER_23166858_ChIP-Seq_MCF-7_Human1.19048118
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15815271
82AR_19668381_ChIP-Seq_PC3_Human1.15768825
83* PRDM14_20953172_ChIP-Seq_ESCs_Human1.15646739
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14692740
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13645462
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13542607
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12455039
88AHR_22903824_ChIP-Seq_MCF-7_Human1.12225483
89* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11245095
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.11122786
91* SOX9_26525672_Chip-Seq_HEART_Mouse1.09653649
92* TP53_20018659_ChIP-ChIP_R1E_Mouse1.09216497
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08948384
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08726719
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.08449332
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06477740
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.04725092
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02903667
99JUN_21703547_ChIP-Seq_K562_Human1.02418966
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01580200
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.01475640
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01415564
103* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00265181
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99317038
105IGF1R_20145208_ChIP-Seq_DFB_Human0.99201727
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98730961
107* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97880647
108SALL1_21062744_ChIP-ChIP_HESCs_Human0.97791600
109E2F1_18555785_Chip-Seq_ESCs_Mouse0.97471240
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96693989
111* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96096775
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95809562
113EWS_26573619_Chip-Seq_HEK293_Human0.95534091
114TP53_16413492_ChIP-PET_HCT116_Human0.95495478
115* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93936669
116RXR_22108803_ChIP-Seq_LS180_Human0.93686018
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93378090
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.91377405
119* TET1_21490601_ChIP-Seq_MESCs_Mouse0.91150373
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91049825
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90597703
122* ISL1_27105846_Chip-Seq_CPCs_Mouse0.90578067
123CTCF_27219007_Chip-Seq_Bcells_Human0.87140598
124* SMAD4_21741376_ChIP-Seq_HESCs_Human0.85965372
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85805863
126* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84460951
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83401330
128* SMAD3_21741376_ChIP-Seq_HESCs_Human0.82203316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.84569039
2MP0003880_abnormal_central_pattern5.07706993
3MP0003635_abnormal_synaptic_transmissio3.66041738
4MP0004270_analgesia3.49127495
5MP0002063_abnormal_learning/memory/cond3.20572697
6MP0003787_abnormal_imprinting3.16012418
7MP0001968_abnormal_touch/_nociception3.12202296
8MP0002736_abnormal_nociception_after3.11486753
9MP0009745_abnormal_behavioral_response2.85814183
10MP0005423_abnormal_somatic_nervous2.59259445
11MP0002064_seizures2.57784693
12MP0002734_abnormal_mechanical_nocicepti2.51934546
13MP0000778_abnormal_nervous_system2.48344693
14MP0002572_abnormal_emotion/affect_behav2.48144484
15MP0009780_abnormal_chondrocyte_physiolo2.47247839
16MP0001486_abnormal_startle_reflex2.12839219
17MP0009046_muscle_twitch2.08679833
18MP0002184_abnormal_innervation2.04458164
19MP0003329_amyloid_beta_deposits2.03260326
20MP0002735_abnormal_chemical_nociception2.02462072
21MP0001188_hyperpigmentation1.91438296
22MP0001440_abnormal_grooming_behavior1.81679703
23MP0002272_abnormal_nervous_system1.81127874
24MP0004858_abnormal_nervous_system1.79544481
25MP0003122_maternal_imprinting1.76433289
26MP0006292_abnormal_olfactory_placode1.76006583
27MP0005646_abnormal_pituitary_gland1.70107547
28MP0002067_abnormal_sensory_capabilities1.63138715
29MP0005645_abnormal_hypothalamus_physiol1.62832262
30MP0004811_abnormal_neuron_physiology1.59374098
31MP0002733_abnormal_thermal_nociception1.58544668
32MP0006276_abnormal_autonomic_nervous1.56818448
33MP0002557_abnormal_social/conspecific_i1.56432122
34MP0003879_abnormal_hair_cell1.55566111
35MP0001501_abnormal_sleep_pattern1.53414728
36MP0001970_abnormal_pain_threshold1.49553139
37MP0001984_abnormal_olfaction1.48903874
38MP0005386_behavior/neurological_phenoty1.46546358
39MP0004924_abnormal_behavior1.46546358
40MP0005499_abnormal_olfactory_system1.44677491
41MP0005394_taste/olfaction_phenotype1.44677491
42MP0000955_abnormal_spinal_cord1.43327917
43MP0008569_lethality_at_weaning1.38194939
44MP0002822_catalepsy1.37772848
45MP0002909_abnormal_adrenal_gland1.36131370
46MP0003121_genomic_imprinting1.30350015
47MP0004134_abnormal_chest_morphology1.28038250
48MP0005171_absent_coat_pigmentation1.24754408
49MP0002882_abnormal_neuron_morphology1.23817564
50MP0000566_synostosis1.20177297
51MP0003283_abnormal_digestive_organ1.19637914
52MP0004885_abnormal_endolymph1.17302545
53MP0002066_abnormal_motor_capabilities/c1.15777614
54MP0002152_abnormal_brain_morphology1.14938241
55MP0001502_abnormal_circadian_rhythm1.14246150
56MP0000631_abnormal_neuroendocrine_gland1.12808144
57MP0001529_abnormal_vocalization1.11464772
58MP0001177_atelectasis1.10223661
59MP0003634_abnormal_glial_cell1.07920197
60MP0000920_abnormal_myelination1.06240229
61MP0003690_abnormal_glial_cell1.03986255
62MP0001963_abnormal_hearing_physiology0.97898064
63MP0003123_paternal_imprinting0.97801691
64MP0008789_abnormal_olfactory_epithelium0.97719045
65MP0002751_abnormal_autonomic_nervous0.97161479
66MP0002282_abnormal_trachea_morphology0.95550494
67MP0001346_abnormal_lacrimal_gland0.95156698
68MP0001905_abnormal_dopamine_level0.92767316
69MP0000751_myopathy0.92047436
70MP0009250_abnormal_appendicular_skeleto0.91923895
71MP0002876_abnormal_thyroid_physiology0.91323796
72MP0003861_abnormal_nervous_system0.88971343
73MP0003755_abnormal_palate_morphology0.88507882
74MP0008877_abnormal_DNA_methylation0.87024566
75MP0010386_abnormal_urinary_bladder0.86285394
76MP0000579_abnormal_nail_morphology0.85859442
77MP0004085_abnormal_heartbeat0.85248639
78MP0002069_abnormal_eating/drinking_beha0.84274638
79MP0005248_abnormal_Harderian_gland0.83007069
80MP0004484_altered_response_of0.82811379
81MP0003633_abnormal_nervous_system0.82400333
82MP0003385_abnormal_body_wall0.82283626
83MP0002229_neurodegeneration0.81983288
84MP0002249_abnormal_larynx_morphology0.81615301
85MP0003632_abnormal_nervous_system0.81170884
86MP0000026_abnormal_inner_ear0.80662366
87MP0003119_abnormal_digestive_system0.80571272
88MP0002638_abnormal_pupillary_reflex0.80470150
89MP0005084_abnormal_gallbladder_morpholo0.80417244
90MP0005187_abnormal_penis_morphology0.80397367
91MP0008004_abnormal_stomach_pH0.80069074
92MP0002116_abnormal_craniofacial_bone0.78847766
93MP0000604_amyloidosis0.78664178
94MP0000049_abnormal_middle_ear0.78625750
95MP0005503_abnormal_tendon_morphology0.77632115
96MP0004742_abnormal_vestibular_system0.76309838
97MP0001485_abnormal_pinna_reflex0.74269267
98MP0003942_abnormal_urinary_system0.74145422
99MP0003631_nervous_system_phenotype0.73741893
100MP0003938_abnormal_ear_development0.73690291
101MP0002752_abnormal_somatic_nervous0.72433246
102MP0001299_abnormal_eye_distance/0.71887163
103MP0000534_abnormal_ureter_morphology0.71634536
104MP0001943_abnormal_respiration0.69450601
105MP0002081_perinatal_lethality0.69109247
106MP0002233_abnormal_nose_morphology0.68906821
107MP0002896_abnormal_bone_mineralization0.67668180
108MP0000015_abnormal_ear_pigmentation0.66269224
109MP0010769_abnormal_survival0.65192989
110MP0002082_postnatal_lethality0.65174408
111MP0010770_preweaning_lethality0.65174408
112MP0000569_abnormal_digit_pigmentation0.64045366
113MP0000537_abnormal_urethra_morphology0.63817790
114MP0000163_abnormal_cartilage_morphology0.62115168
115MP0005623_abnormal_meninges_morphology0.61160005
116MP0003890_abnormal_embryonic-extraembry0.60939101
117MP0010768_mortality/aging0.60794388
118MP0001348_abnormal_lacrimal_gland0.60512820
119MP0002102_abnormal_ear_morphology0.60500749
120MP0005551_abnormal_eye_electrophysiolog0.60347543
121MP0005409_darkened_coat_color0.58318683
122MP0008874_decreased_physiological_sensi0.56616880
123MP0004142_abnormal_muscle_tone0.52353666
124MP0004133_heterotaxia0.49017153

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.03372840
2Epileptic encephalopathy (HP:0200134)4.78625676
3Myokymia (HP:0002411)4.47818305
4Supranuclear gaze palsy (HP:0000605)4.26228423
5Epiphyseal dysplasia (HP:0002656)4.25835149
6Focal seizures (HP:0007359)4.14522876
7Hyperventilation (HP:0002883)3.89518408
8Neurofibrillary tangles (HP:0002185)3.88089220
9Vitreoretinal degeneration (HP:0000655)3.82301689
10Irregular epiphyses (HP:0010582)3.77238063
11Hepatoblastoma (HP:0002884)3.56907213
12Febrile seizures (HP:0002373)3.55980921
13Abnormality of binocular vision (HP:0011514)3.54287147
14Diplopia (HP:0000651)3.54287147
15Amblyopia (HP:0000646)3.40916437
16Broad-based gait (HP:0002136)3.36155733
17Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.34884792
18Atonic seizures (HP:0010819)3.34272305
19Spastic gait (HP:0002064)3.22456627
20Cerebral inclusion bodies (HP:0100314)3.15019469
21Papilledema (HP:0001085)3.05400300
22Visual hallucinations (HP:0002367)3.00775506
23Postural instability (HP:0002172)2.82058199
24Dysmetria (HP:0001310)2.76256998
25Progressive cerebellar ataxia (HP:0002073)2.75998773
26Akinesia (HP:0002304)2.70655797
27Obstructive sleep apnea (HP:0002870)2.69421332
28Absence seizures (HP:0002121)2.68419604
29Impaired vibration sensation in the lower limbs (HP:0002166)2.61547961
30Status epilepticus (HP:0002133)2.59158972
31Mild short stature (HP:0003502)2.58807863
32Hemiplegia (HP:0002301)2.58347152
33Annular pancreas (HP:0001734)2.57330683
34Generalized tonic-clonic seizures (HP:0002069)2.56855762
35Drooling (HP:0002307)2.55370310
36Excessive salivation (HP:0003781)2.55370310
37Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.54727313
38Absent epiphyses (HP:0010577)2.54727313
39Megalencephaly (HP:0001355)2.52012078
40Dialeptic seizures (HP:0011146)2.48081187
41Lower limb muscle weakness (HP:0007340)2.43944496
42Intention tremor (HP:0002080)2.43915396
43Genu varum (HP:0002970)2.40096085
44Abnormality of the lower motor neuron (HP:0002366)2.39244574
45Insomnia (HP:0100785)2.38053748
46Protruding tongue (HP:0010808)2.37484151
47Craniofacial dystonia (HP:0012179)2.37438927
48Abnormality of the labia minora (HP:0012880)2.37081402
49Mutism (HP:0002300)2.34957973
50Poor eye contact (HP:0000817)2.34685795
51Neuronal loss in central nervous system (HP:0002529)2.34210782
52Epileptiform EEG discharges (HP:0011182)2.32507777
53Flat capital femoral epiphysis (HP:0003370)2.24397692
54Gaze-evoked nystagmus (HP:0000640)2.23768991
55Blue irides (HP:0000635)2.21700048
56Hemiparesis (HP:0001269)2.21601694
57Relative macrocephaly (HP:0004482)2.19652128
58Fetal akinesia sequence (HP:0001989)2.19623016
59Apathy (HP:0000741)2.17160556
60Aplasia/Hypoplasia of the sternum (HP:0006714)2.15982408
61Scanning speech (HP:0002168)2.15078890
62Bronchomalacia (HP:0002780)2.14592974
63Tracheomalacia (HP:0002779)2.13613055
64Aplasia of the phalanges of the hand (HP:0009802)2.13112836
65Aplasia involving bones of the extremities (HP:0009825)2.13112836
66Aplasia involving bones of the upper limbs (HP:0009823)2.13112836
67Gait imbalance (HP:0002141)2.12437977
68Abnormality of femoral epiphyses (HP:0006499)2.12159003
69Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.12159003
70Bradykinesia (HP:0002067)2.12121440
71Neonatal short-limb short stature (HP:0008921)2.12000672
72Abnormal eating behavior (HP:0100738)2.11608350
73Split foot (HP:0001839)2.11426378
74Tetraplegia (HP:0002445)2.11125149
75Sleep apnea (HP:0010535)2.10184075
76Ankle clonus (HP:0011448)2.09057032
77Lower limb asymmetry (HP:0100559)2.07434725
78Arthropathy (HP:0003040)2.07239602
79Torticollis (HP:0000473)2.05291217
80Stereotypic behavior (HP:0000733)2.05027817
81Anxiety (HP:0000739)2.04015780
82Hypoplastic ischia (HP:0003175)2.02998706
83Absent speech (HP:0001344)2.02470036
84Impaired vibratory sensation (HP:0002495)2.02381061
85Morphological abnormality of the pyramidal tract (HP:0002062)2.01268756
86Enlarged kidneys (HP:0000105)2.01097444
87Fibular hypoplasia (HP:0003038)2.01022639
88Small epiphyses (HP:0010585)2.01004695
89Clonus (HP:0002169)2.00365539
90Abnormality of the epiphysis of the femoral head (HP:0010574)1.99911952
91Thickened helices (HP:0000391)1.99578015
92Incomplete penetrance (HP:0003829)1.99120541
93Peripheral hypomyelination (HP:0007182)1.98230242
94Spastic tetraparesis (HP:0001285)1.97866095
95Inability to walk (HP:0002540)1.97319399
96EEG with generalized epileptiform discharges (HP:0011198)1.96727754
97Abnormality of the pubic bones (HP:0003172)1.96323998
98Asymmetry of the thorax (HP:0001555)1.96047353
99Dysdiadochokinesis (HP:0002075)1.95986705
100Abnormality of the intervertebral disk (HP:0005108)1.94222389
101Neoplasm of the adrenal cortex (HP:0100641)1.93174448
102Diminished motivation (HP:0000745)1.92127246
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90870941
104Degeneration of the lateral corticospinal tracts (HP:0002314)1.90870941
105Hammertoe (HP:0001765)1.90142819
106Abnormality of the femoral head (HP:0003368)1.89645708
107Limb dystonia (HP:0002451)1.89411544
108Abnormality of incisor morphology (HP:0011063)1.88609961
109Abnormal hair whorl (HP:0010721)1.86625029
110Hypsarrhythmia (HP:0002521)1.85730699
111Focal dystonia (HP:0004373)1.84748719
112Depression (HP:0000716)1.84373977
113Impaired smooth pursuit (HP:0007772)1.83405137
114Hypoplasia of the brainstem (HP:0002365)1.82931755
115Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82931755
116Lower limb amyotrophy (HP:0007210)1.82195050
117Overgrowth (HP:0001548)1.81134788
118Urinary bladder sphincter dysfunction (HP:0002839)1.81104126
119Polyphagia (HP:0002591)1.81023546
120Urinary urgency (HP:0000012)1.80965971
121Cupped ribs (HP:0000887)1.80727158
122Abnormality of salivation (HP:0100755)1.80709925
123Termporal pattern (HP:0011008)1.80347549
124Insidious onset (HP:0003587)1.80347549
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80328065
126Omphalocele (HP:0001539)1.80163813
127Abnormal social behavior (HP:0012433)1.80032515
128Impaired social interactions (HP:0000735)1.80032515
129Long clavicles (HP:0000890)1.78125909
130Gastroesophageal reflux (HP:0002020)1.76781782
131Abnormality of the corticospinal tract (HP:0002492)1.76719494
132Cutaneous finger syndactyly (HP:0010554)1.76167592
133Spinal cord compression (HP:0002176)1.75956500
134Abnormality of the ischium (HP:0003174)1.73973977
135Heterochromia iridis (HP:0001100)1.73719159
136Cerebral hypomyelination (HP:0006808)1.73398424
137Pointed chin (HP:0000307)1.72725136
138Turricephaly (HP:0000262)1.71820047
139Spastic tetraplegia (HP:0002510)1.69916066
140Abnormality of the proximal phalanges of the hand (HP:0009834)1.69677712
141Rapidly progressive (HP:0003678)1.69504231
142Spinal canal stenosis (HP:0003416)1.68432619
143Hypoplasia of the corpus callosum (HP:0002079)1.67505049
144Action tremor (HP:0002345)1.67162241
145Poor coordination (HP:0002370)1.67034068
146Arterial tortuosity (HP:0005116)1.66537162
147Delusions (HP:0000746)1.66273054
148Truncal ataxia (HP:0002078)1.66222914
149Specific learning disability (HP:0001328)1.66182119
150Hand muscle atrophy (HP:0009130)1.65625688
151Amyotrophic lateral sclerosis (HP:0007354)1.64371744
152Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64058362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.41086059
2CASK4.14265234
3EPHA43.71841008
4NTRK33.28868088
5DAPK22.85908369
6PLK22.73174345
7MAP2K72.72888112
8PRPF4B2.60216693
9MINK12.58027468
10MAP3K42.55532464
11NTRK22.16495529
12MAP3K92.04182326
13MAPK132.03260906
14CCNB12.02334065
15DAPK11.99782404
16ERBB31.96735445
17MAP3K121.86034557
18SIK31.84709102
19AKT31.83137599
20KSR11.79173798
21CDK191.76977271
22FGFR21.68843608
23PRKD31.54857386
24TYRO31.54342369
25SGK21.53469593
26MAP2K41.40292762
27DYRK1A1.40038679
28CDK51.27988409
29SGK2231.25482838
30SGK4941.25482838
31PAK61.22820962
32BMPR21.21623226
33NME11.20391093
34PRKCG1.12585022
35DDR21.10314040
36CAMK2B1.06403587
37STK241.05571027
38SGK31.05398483
39PNCK1.04978800
40PAK31.04205867
41RIPK11.03652114
42BCR1.01307847
43GRK50.98457454
44CAMKK10.98361862
45PTK2B0.95339807
46CDK180.95278227
47STK38L0.95156514
48SIK20.91460675
49CAMK2A0.89958511
50UHMK10.86700830
51OXSR10.84704977
52DYRK20.84170932
53CDK150.83394105
54LATS20.82608160
55CDK140.77442283
56TSSK60.75039048
57CAMKK20.74375575
58MARK20.73208168
59ALK0.72863230
60CDK11A0.70761734
61TNIK0.66771084
62SGK10.65535910
63PKN10.65338567
64CAMK1G0.64747924
65PDGFRA0.63221111
66RIPK40.63216037
67PLK30.61821338
68TAOK20.59973030
69PRKCH0.59705609
70PHKG10.57894521
71PHKG20.57894521
72ROCK20.57656786
73KSR20.57638229
74LIMK10.57594837
75GRK70.56733140
76SRPK10.56658743
77YES10.55350354
78FGFR30.55313481
79BRSK10.54786891
80BRAF0.51465329
81LMTK20.50326668
82MAP3K60.50313140
83CAMK2G0.49504848
84MAPK100.49414382
85ERBB20.49173744
86MAPK70.48524961
87RET0.48323359
88CAMK40.47908250
89PRKCZ0.46121340
90PRKCE0.45469081
91RPS6KA20.44248540
92TAOK10.44230777
93EPHB20.43736802
94TESK10.42153015
95MAPK120.41979101
96NTRK10.41854419
97PINK10.41840525
98FGFR10.41442988
99FYN0.41432600
100RAF10.39913193
101STK380.39211217
102CSNK1G20.38450608
103CAMK1D0.38214701
104CAMK10.38052985
105DAPK30.37699613
106PDK30.37348936
107PDK40.37348936
108STK110.37048089
109WNK10.36052268
110ROCK10.35662891
111ADRBK10.34918661
112ARAF0.34165593
113ICK0.34095047
114MAP3K20.33260468
115NEK60.33215996
116BMPR1B0.32347210
117CSNK1A1L0.31964273
118RPS6KA30.31524272
119PDK10.30766114
120EPHA30.29027297
121FES0.29006752
122CAMK2D0.28891390
123PTK20.28733263
124RPS6KB10.28203451
125CSNK1D0.27979128
126MAPK80.26231369
127CSNK1E0.25567780
128SRC0.24742151
129CSNK1G30.24697393

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94651794
2Synaptic vesicle cycle_Homo sapiens_hsa047213.45972218
3Olfactory transduction_Homo sapiens_hsa047403.18532897
4Circadian entrainment_Homo sapiens_hsa047132.84200193
5Long-term potentiation_Homo sapiens_hsa047202.78565134
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65256607
7Amphetamine addiction_Homo sapiens_hsa050312.60543943
8Glutamatergic synapse_Homo sapiens_hsa047242.47054428
9Morphine addiction_Homo sapiens_hsa050322.43213402
10GABAergic synapse_Homo sapiens_hsa047272.28696656
11Dopaminergic synapse_Homo sapiens_hsa047282.26706651
12Salivary secretion_Homo sapiens_hsa049701.98260540
13Collecting duct acid secretion_Homo sapiens_hsa049661.89118170
14Long-term depression_Homo sapiens_hsa047301.87297208
15Insulin secretion_Homo sapiens_hsa049111.82364997
16Axon guidance_Homo sapiens_hsa043601.81708094
17Cholinergic synapse_Homo sapiens_hsa047251.76861636
18Taste transduction_Homo sapiens_hsa047421.75733364
19Serotonergic synapse_Homo sapiens_hsa047261.70568117
20Renin secretion_Homo sapiens_hsa049241.70474845
21Oxytocin signaling pathway_Homo sapiens_hsa049211.63000870
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61072927
23Vibrio cholerae infection_Homo sapiens_hsa051101.56666253
24Calcium signaling pathway_Homo sapiens_hsa040201.55246802
25Gastric acid secretion_Homo sapiens_hsa049711.50690076
26Cocaine addiction_Homo sapiens_hsa050301.50556442
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48625368
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47377308
29Gap junction_Homo sapiens_hsa045401.45456305
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44219063
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40634671
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39688663
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34268617
34ErbB signaling pathway_Homo sapiens_hsa040121.34018311
35Glioma_Homo sapiens_hsa052141.33972657
36GnRH signaling pathway_Homo sapiens_hsa049121.28305559
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20945871
38cAMP signaling pathway_Homo sapiens_hsa040241.17994671
39Melanogenesis_Homo sapiens_hsa049161.16945289
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14927880
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08233246
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06604149
43Vitamin B6 metabolism_Homo sapiens_hsa007501.00693409
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00624520
45Type II diabetes mellitus_Homo sapiens_hsa049300.97940809
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97127442
47Estrogen signaling pathway_Homo sapiens_hsa049150.95454154
48Phototransduction_Homo sapiens_hsa047440.89606354
49MAPK signaling pathway_Homo sapiens_hsa040100.88517028
50Oocyte meiosis_Homo sapiens_hsa041140.87498116
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86817268
52Wnt signaling pathway_Homo sapiens_hsa043100.85746234
53Endometrial cancer_Homo sapiens_hsa052130.80125024
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.78772164
55Prion diseases_Homo sapiens_hsa050200.77928695
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77483763
57Ras signaling pathway_Homo sapiens_hsa040140.76984547
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.76205122
59Bile secretion_Homo sapiens_hsa049760.74276998
60Colorectal cancer_Homo sapiens_hsa052100.73440340
61Dilated cardiomyopathy_Homo sapiens_hsa054140.71988305
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69350501
63Rap1 signaling pathway_Homo sapiens_hsa040150.69004994
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65279820
65VEGF signaling pathway_Homo sapiens_hsa043700.62911710
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62680009
67Circadian rhythm_Homo sapiens_hsa047100.61921388
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61328882
69Choline metabolism in cancer_Homo sapiens_hsa052310.61234272
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60870343
71Hippo signaling pathway_Homo sapiens_hsa043900.60684488
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57724578
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57077970
74Hedgehog signaling pathway_Homo sapiens_hsa043400.55579404
75Phagosome_Homo sapiens_hsa041450.54651454
76Tight junction_Homo sapiens_hsa045300.53446478
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53197916
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50365936
79Glucagon signaling pathway_Homo sapiens_hsa049220.49263640
80Alcoholism_Homo sapiens_hsa050340.48782126
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.48725504
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48084629
83Endocytosis_Homo sapiens_hsa041440.47691101
84Non-small cell lung cancer_Homo sapiens_hsa052230.45852257
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44914392
86Melanoma_Homo sapiens_hsa052180.44222426
87Thyroid hormone synthesis_Homo sapiens_hsa049180.43416819
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.43070553
89Renal cell carcinoma_Homo sapiens_hsa052110.41390342
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41378606
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41058072
92Inositol phosphate metabolism_Homo sapiens_hsa005620.40522310
93Fatty acid biosynthesis_Homo sapiens_hsa000610.39614244
94Dorso-ventral axis formation_Homo sapiens_hsa043200.38287398
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38020673
96Pancreatic secretion_Homo sapiens_hsa049720.37740952
97Basal cell carcinoma_Homo sapiens_hsa052170.37342141
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36401398
99FoxO signaling pathway_Homo sapiens_hsa040680.36006356
100ECM-receptor interaction_Homo sapiens_hsa045120.34875159
101Rheumatoid arthritis_Homo sapiens_hsa053230.33945299
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33767964
103Cardiac muscle contraction_Homo sapiens_hsa042600.33652126
104Adherens junction_Homo sapiens_hsa045200.33597039
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33125776
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31715023
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31043289
108African trypanosomiasis_Homo sapiens_hsa051430.30146579
109Insulin signaling pathway_Homo sapiens_hsa049100.30088453
110Protein digestion and absorption_Homo sapiens_hsa049740.30051294
111AMPK signaling pathway_Homo sapiens_hsa041520.29600287
112mTOR signaling pathway_Homo sapiens_hsa041500.29214899
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29202917
114Ovarian steroidogenesis_Homo sapiens_hsa049130.29122990
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28195335
116Focal adhesion_Homo sapiens_hsa045100.27832840

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »