ENDOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.14428547
2central nervous system myelination (GO:0022010)8.14428547
3hemidesmosome assembly (GO:0031581)5.45536951
4fatty acid elongation (GO:0030497)5.37767771
5ensheathment of neurons (GO:0007272)4.88773229
6axon ensheathment (GO:0008366)4.88773229
7myelination (GO:0042552)4.86496023
8desmosome organization (GO:0002934)4.77630989
9long-chain fatty acid biosynthetic process (GO:0042759)4.63381939
10myelin maintenance (GO:0043217)4.36895836
11neuronal action potential propagation (GO:0019227)4.02017530
12negative regulation of neurotransmitter transport (GO:0051589)3.99944158
13establishment of mitochondrion localization (GO:0051654)3.96819252
14neurofilament cytoskeleton organization (GO:0060052)3.91688490
15negative regulation of neurotransmitter secretion (GO:0046929)3.91587186
16synaptic vesicle maturation (GO:0016188)3.74975926
17cell-substrate junction assembly (GO:0007044)3.74710755
18L-amino acid import (GO:0043092)3.72130256
19response to methylmercury (GO:0051597)3.66056100
20neuron cell-cell adhesion (GO:0007158)3.47762847
21apical protein localization (GO:0045176)3.41158077
22adult walking behavior (GO:0007628)3.31679277
23hypotonic response (GO:0006971)3.30486130
24iron ion import (GO:0097286)3.29163440
25glycine transport (GO:0015816)3.24468129
26positive regulation of Rho protein signal transduction (GO:0035025)3.23459969
27synaptic vesicle exocytosis (GO:0016079)3.22585899
28peptidyl-tyrosine autophosphorylation (GO:0038083)3.19329845
29transmission of nerve impulse (GO:0019226)3.17204590
30asymmetric protein localization (GO:0008105)3.17005195
31regulation of integrin-mediated signaling pathway (GO:2001044)3.16366899
32regulation of synaptic vesicle exocytosis (GO:2000300)3.16031067
33mesodermal cell differentiation (GO:0048333)3.15790766
34positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.14364656
35positive regulation of receptor recycling (GO:0001921)3.10233701
36negative regulation of protein localization to cell surface (GO:2000009)3.09654802
37axon development (GO:0061564)3.07185061
38presynaptic membrane organization (GO:0097090)3.06282686
39detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.05947065
40detection of temperature stimulus involved in sensory perception (GO:0050961)3.05947065
41cellular potassium ion homeostasis (GO:0030007)3.05788266
42beta-amyloid metabolic process (GO:0050435)3.04067572
43oligodendrocyte differentiation (GO:0048709)3.01620350
44negative regulation of homotypic cell-cell adhesion (GO:0034111)3.01619597
45mating behavior (GO:0007617)2.99461735
46amyloid precursor protein metabolic process (GO:0042982)2.97349787
47glutamate secretion (GO:0014047)2.96838116
48regulation of water loss via skin (GO:0033561)2.95001976
49negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.94207839
50eye photoreceptor cell differentiation (GO:0001754)2.91753373
51photoreceptor cell differentiation (GO:0046530)2.91753373
52establishment of skin barrier (GO:0061436)2.91153090
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91083480
54actin-myosin filament sliding (GO:0033275)2.90840424
55muscle filament sliding (GO:0030049)2.90840424
56cholesterol biosynthetic process (GO:0006695)2.90588993
57COPI coating of Golgi vesicle (GO:0048205)2.90326321
58Golgi transport vesicle coating (GO:0048200)2.90326321
59regulation of short-term neuronal synaptic plasticity (GO:0048172)2.89032358
60potassium ion homeostasis (GO:0055075)2.88518996
61import into cell (GO:0098657)2.88110921
62regulation of collateral sprouting (GO:0048670)2.88054652
63glycerophospholipid catabolic process (GO:0046475)2.88024392
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.87794788
65regulation of platelet aggregation (GO:0090330)2.87299067
66substantia nigra development (GO:0021762)2.86230951
67amino acid import (GO:0043090)2.85683496
68regulation of early endosome to late endosome transport (GO:2000641)2.84748269
69long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.83516840
70presynaptic membrane assembly (GO:0097105)2.82284723
71nerve growth factor signaling pathway (GO:0038180)2.80585993
72neuromuscular process controlling posture (GO:0050884)2.80291918
73sarcoplasmic reticulum calcium ion transport (GO:0070296)2.80234771
74potassium ion import (GO:0010107)2.79278457
75detection of temperature stimulus (GO:0016048)2.79203691
76regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78957251
77protein targeting to plasma membrane (GO:0072661)2.76848230
78neuronal ion channel clustering (GO:0045161)2.74978068
79negative regulation of axonogenesis (GO:0050771)2.74584847
80long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.70909120
81bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70319278
82regulation of clathrin-mediated endocytosis (GO:2000369)2.69733890
83astrocyte development (GO:0014002)2.68441309
84cytoskeletal anchoring at plasma membrane (GO:0007016)2.67729172
85neuron recognition (GO:0008038)2.67645486
86regulation of protein localization to cell surface (GO:2000008)2.67107446
87protein localization to endosome (GO:0036010)2.67095165
88positive regulation of oligodendrocyte differentiation (GO:0048714)2.66872397
89sodium ion export (GO:0071436)2.66620081
90platelet degranulation (GO:0002576)2.65129062
91positive regulation of potassium ion transport (GO:0043268)2.64712082
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64468695
93establishment of protein localization to plasma membrane (GO:0090002)2.64452146
94neurotransmitter uptake (GO:0001504)2.63025719
95membrane raft organization (GO:0031579)2.62025296
96Golgi to plasma membrane transport (GO:0006893)2.62020098
97relaxation of muscle (GO:0090075)2.61092917
98synaptic vesicle docking involved in exocytosis (GO:0016081)2.60817770
99plasma membrane repair (GO:0001778)2.59777830
100creatine metabolic process (GO:0006600)2.59712543
101negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.59660502
102organelle transport along microtubule (GO:0072384)2.59612239
103negative regulation of inclusion body assembly (GO:0090084)2.59489141
104epithelial cell-cell adhesion (GO:0090136)2.59088507
105regulation of amyloid precursor protein catabolic process (GO:1902991)2.58846326
106magnesium ion transport (GO:0015693)2.58011823
107actin-mediated cell contraction (GO:0070252)2.57950041
108Golgi to plasma membrane protein transport (GO:0043001)2.57759353
109sterol biosynthetic process (GO:0016126)2.57338629
110response to lipoprotein particle (GO:0055094)2.56789900
111extracellular fibril organization (GO:0043206)2.56786384
112regulation of synaptic vesicle transport (GO:1902803)2.56679195
113calcium-mediated signaling using intracellular calcium source (GO:0035584)2.55813259
114positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.54944457
115adenosine receptor signaling pathway (GO:0001973)2.52965106
116protein palmitoylation (GO:0018345)2.52662820
117regulation of voltage-gated calcium channel activity (GO:1901385)2.52179053
118gamma-aminobutyric acid transport (GO:0015812)2.51425769
119positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.49075593
120peripheral nervous system axon ensheathment (GO:0032292)2.48793866
121myelination in peripheral nervous system (GO:0022011)2.48793866
122cell adhesion mediated by integrin (GO:0033627)2.48768215
123axon cargo transport (GO:0008088)2.48657075
124response to lead ion (GO:0010288)2.48490946
125adherens junction assembly (GO:0034333)2.47853360
126glycosylceramide metabolic process (GO:0006677)2.47852700
127neuron remodeling (GO:0016322)2.47373967
128regulation of neuronal synaptic plasticity (GO:0048168)2.47181779
129skin morphogenesis (GO:0043589)2.47112882
130skeletal muscle contraction (GO:0003009)2.47078084
131regulation of lipoprotein metabolic process (GO:0050746)2.46732816
132adhesion of symbiont to host cell (GO:0044650)2.46310527
133virion attachment to host cell (GO:0019062)2.46310527
134thrombin receptor signaling pathway (GO:0070493)2.45247085
135barbed-end actin filament capping (GO:0051016)2.44818037
136vesicle transport along microtubule (GO:0047496)2.44639281
137dendrite morphogenesis (GO:0048813)2.44246659
138stress fiber assembly (GO:0043149)2.44121533
139gamma-aminobutyric acid signaling pathway (GO:0007214)2.43955047
140regulation of receptor recycling (GO:0001919)2.43361077
141keratinocyte proliferation (GO:0043616)2.42544112
142actin filament-based movement (GO:0030048)2.42200051
143vocalization behavior (GO:0071625)2.41829514
144membrane tubulation (GO:0097320)2.41726762
145platelet aggregation (GO:0070527)2.40714946
146enteric nervous system development (GO:0048484)2.40225800
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.39531818
148adult locomotory behavior (GO:0008344)2.39254371
149cell-substrate adherens junction assembly (GO:0007045)2.38748784
150focal adhesion assembly (GO:0048041)2.38748784
151axonal fasciculation (GO:0007413)2.38396637
152neurotransmitter transport (GO:0006836)2.37477146
153positive regulation of potassium ion transmembrane transport (GO:1901381)2.36348618
154mitochondrion transport along microtubule (GO:0047497)2.35917108
155establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.35917108
156sensory perception of smell (GO:0007608)2.35472029
157regulation of protein localization to plasma membrane (GO:1903076)2.34883731
158negative regulation of protein localization to plasma membrane (GO:1903077)2.32538304
159linoleic acid metabolic process (GO:0043651)2.31833602
160regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.31128099
161protein localization to plasma membrane (GO:0072659)2.30875420
162activation of protein kinase A activity (GO:0034199)2.30125064
163negative regulation of cell junction assembly (GO:1901889)2.29993911
164negative regulation of adherens junction organization (GO:1903392)2.29993911
165negative regulation of focal adhesion assembly (GO:0051895)2.29993911
166regulation of establishment of protein localization to plasma membrane (GO:0090003)2.29849738
167cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.28797454
168fibril organization (GO:0097435)2.27169526
169positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.26302734
170endocytic recycling (GO:0032456)2.24930642
171cell junction assembly (GO:0034329)2.22242247
172relaxation of smooth muscle (GO:0044557)2.21640900
173positive regulation of cardiac muscle hypertrophy (GO:0010613)2.21188966
174positive regulation of muscle hypertrophy (GO:0014742)2.21188966
175retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.20948173
176negative regulation of potassium ion transmembrane transport (GO:1901380)2.20911184
177regulation of transforming growth factor beta2 production (GO:0032909)2.19995824
178positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.18703252
179maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.18343184
180negative regulation of muscle contraction (GO:0045932)2.17816651
181regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.17139007
182striated muscle contraction (GO:0006941)2.16583120
183cerebellar granule cell differentiation (GO:0021707)2.16174845
184cell communication involved in cardiac conduction (GO:0086065)2.15960902
185response to parathyroid hormone (GO:0071107)2.15920204
186protein retention in ER lumen (GO:0006621)2.15706598
187regulation of ARF protein signal transduction (GO:0032012)2.15001766
188plasma membrane organization (GO:0007009)2.14594846
189regulation of homotypic cell-cell adhesion (GO:0034110)2.12564326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.75477385
2EZH2_22144423_ChIP-Seq_EOC_Human3.27408410
3GBX2_23144817_ChIP-Seq_PC3_Human3.02598030
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76662413
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73696001
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64669517
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61977610
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54033249
9GATA2_21666600_ChIP-Seq_HMVEC_Human2.51657121
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37474345
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34045964
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34037339
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34037339
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28904938
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22423725
16TAF15_26573619_Chip-Seq_HEK293_Human2.18725515
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15256139
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12115048
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10380284
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05920924
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05183614
22AR_21572438_ChIP-Seq_LNCaP_Human2.02651581
23DROSHA_22980978_ChIP-Seq_HELA_Human1.99658063
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.97917558
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.97596072
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.95915589
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95408418
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95327636
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95327636
30ZNF263_19887448_ChIP-Seq_K562_Human1.89643065
31GATA1_22025678_ChIP-Seq_K562_Human1.86015210
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84948169
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.84581793
34CLOCK_20551151_ChIP-Seq_293T_Human1.84001331
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.81258360
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75537521
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75280647
38GATA1_19941826_ChIP-Seq_K562_Human1.71621344
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.70442634
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70171347
41REST_21632747_ChIP-Seq_MESCs_Mouse1.65486906
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.64816738
43* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61958439
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61693970
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.58682928
46* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55941272
47SOX2_20726797_ChIP-Seq_SW620_Human1.54586593
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.52741374
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.52741374
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52215793
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51556129
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51056275
53AR_21909140_ChIP-Seq_LNCAP_Human1.50303199
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49692683
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46669514
56* GATA2_19941826_ChIP-Seq_K562_Human1.46053897
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45607039
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45325448
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44532739
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43047513
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41769525
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38996187
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38128212
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38064144
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37584840
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36907983
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.36228283
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35685990
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33780731
70* GATA1_19941827_ChIP-Seq_MEL_Mouse1.33115642
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33102571
72* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32886190
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.32751805
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31751463
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31629742
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31121761
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30098833
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29704884
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29560035
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.29384539
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28703308
82* SMAD4_21799915_ChIP-Seq_A2780_Human1.27080785
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27054587
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26974063
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24855116
86* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24382392
87CJUN_26792858_Chip-Seq_BT549_Human1.23163852
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22915572
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.20928569
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20761169
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20423452
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.20236002
93RACK7_27058665_Chip-Seq_MCF-7_Human1.20123756
94ER_23166858_ChIP-Seq_MCF-7_Human1.20050539
95AHR_22903824_ChIP-Seq_MCF-7_Human1.19606919
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18969097
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18969097
98P300_19829295_ChIP-Seq_ESCs_Human1.18824054
99VDR_22108803_ChIP-Seq_LS180_Human1.18788968
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16477847
101* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15880626
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15149098
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15010736
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14897956
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.14564993
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.14448645
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13357736
108STAT3_23295773_ChIP-Seq_U87_Human1.12967674
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12740464
110* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11367278
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11241741
112TP63_23658742_ChIP-Seq_EP156T_Human1.11166156
113* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10743196
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.10735264
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09715721
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.09439131
117LXR_22158963_ChIP-Seq_LIVER_Mouse1.09039608
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09031826
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08417769
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08240704
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.07868100
122ELK3_25401928_ChIP-Seq_HUVEC_Human1.06845158
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.06184463
124SCL_19346495_ChIP-Seq_HPC-7_Human1.05764348
125KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05609105
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04181878
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.03882617
128NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03750015
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03535233
130RXR_22158963_ChIP-Seq_LIVER_Mouse1.03216838
131ATF3_27146783_Chip-Seq_COLON_Human1.02946499
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02682439
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02107355
134WT1_19549856_ChIP-ChIP_CCG9911_Human1.00765110
135SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99908943
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.98219457
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97389824
138FOXA2_19822575_ChIP-Seq_HepG2_Human0.96881986
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.96439796
140AR_25329375_ChIP-Seq_VCAP_Human0.95750059
141TCF7_22412390_ChIP-Seq_EML_Mouse0.95183187
142SMAD_19615063_ChIP-ChIP_OVARY_Human0.94774238
143* UBF1/2_26484160_Chip-Seq_HMECs_Human0.94320363
144TP53_18474530_ChIP-ChIP_U2OS_Human0.93834803
145IGF1R_20145208_ChIP-Seq_DFB_Human0.92982927
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92617579
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91595159
148TP53_16413492_ChIP-PET_HCT116_Human0.90919820
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90585786
150* TCF4_23295773_ChIP-Seq_U87_Human0.90545201
151NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89274118
152TET1_21490601_ChIP-Seq_MESCs_Mouse0.89084283
153RNF2_27304074_Chip-Seq_NSC_Mouse0.89073310
154SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88461320
155* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87702719
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.87368525
157LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86785278
158RING1B_27294783_Chip-Seq_NPCs_Mouse0.86615219
159ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86508206
160PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86496979
161TCF4_18268006_ChIP-ChIP_LS174T_Human0.86447148
162DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86023830
163RUNX2_22187159_ChIP-Seq_PCA_Human0.85756986
164NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85000333
165* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84780917
166CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84187411
167MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84155040
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83589809
169EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83121652
170NANOG_18555785_Chip-Seq_ESCs_Mouse0.82962501
171SMAD4_21741376_ChIP-Seq_HESCs_Human0.82947293
172ZNF274_21170338_ChIP-Seq_K562_Hela0.82934388
173BRD4_25478319_ChIP-Seq_HGPS_Human0.82776881
174KDM2B_26808549_Chip-Seq_K562_Human0.82532013
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82382570
176YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82332357
177BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81649108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.30833582
2MP0000920_abnormal_myelination3.99840762
3MP0004270_analgesia3.84096486
4MP0010234_abnormal_vibrissa_follicle3.69368487
5MP0004859_abnormal_synaptic_plasticity3.51023270
6MP0003566_abnormal_cell_adhesion3.27476791
7MP0003705_abnormal_hypodermis_morpholog3.18442816
8MP0003329_amyloid_beta_deposits3.05673160
9MP0002272_abnormal_nervous_system2.82377870
10MP0005275_abnormal_skin_tensile2.81506734
11MP0008438_abnormal_cutaneous_collagen2.81438177
12MP0003635_abnormal_synaptic_transmissio2.71429847
13MP0005464_abnormal_platelet_physiology2.67682890
14MP0002064_seizures2.64459933
15MP0002734_abnormal_mechanical_nocicepti2.64080804
16MP0009046_muscle_twitch2.60544465
17MP0001486_abnormal_startle_reflex2.50992500
18MP0003690_abnormal_glial_cell2.44973401
19MP0000749_muscle_degeneration2.41133685
20MP0004272_abnormal_basement_membrane2.40496732
21MP0002735_abnormal_chemical_nociception2.39185592
22MP0002877_abnormal_melanocyte_morpholog2.38331990
23MP0001968_abnormal_touch/_nociception2.37153547
24MP0009745_abnormal_behavioral_response2.30964733
25MP0004036_abnormal_muscle_relaxation2.25405217
26MP0001529_abnormal_vocalization2.14786241
27MP0004510_myositis2.12744612
28MP0001970_abnormal_pain_threshold2.12636173
29MP0002736_abnormal_nociception_after2.09588794
30MP0005423_abnormal_somatic_nervous2.07938528
31MP0004885_abnormal_endolymph2.05343429
32MP0002733_abnormal_thermal_nociception2.04607409
33MP0003634_abnormal_glial_cell2.04578816
34MP0001905_abnormal_dopamine_level2.02140073
35MP0004147_increased_porphyrin_level2.00816779
36MP0003453_abnormal_keratinocyte_physiol2.00127246
37MP0002063_abnormal_learning/memory/cond1.99250976
38MP0004742_abnormal_vestibular_system1.98307850
39MP0004084_abnormal_cardiac_muscle1.93706859
40MP0003045_fibrosis1.93628553
41MP0005451_abnormal_body_composition1.93097631
42MP0004142_abnormal_muscle_tone1.92431034
43MP0003950_abnormal_plasma_membrane1.91847051
44MP0000778_abnormal_nervous_system1.86777063
45MP0003091_abnormal_cell_migration1.81502368
46MP0002572_abnormal_emotion/affect_behav1.80456741
47MP0008569_lethality_at_weaning1.77140724
48MP0002229_neurodegeneration1.74578452
49MP0002067_abnormal_sensory_capabilities1.74237616
50MP0002822_catalepsy1.73171675
51MP0001984_abnormal_olfaction1.71044181
52MP0001440_abnormal_grooming_behavior1.68655802
53MP0001958_emphysema1.64644606
54MP0001485_abnormal_pinna_reflex1.62732469
55MP0002060_abnormal_skin_morphology1.62272272
56MP0000604_amyloidosis1.62222861
57MP0005023_abnormal_wound_healing1.60885355
58MP0003633_abnormal_nervous_system1.59350372
59MP0004858_abnormal_nervous_system1.58923179
60MP0000955_abnormal_spinal_cord1.58814497
61MP0001501_abnormal_sleep_pattern1.57765574
62MP0004233_abnormal_muscle_weight1.57645506
63MP0010352_gastrointestinal_tract_polyps1.55682711
64MP0003191_abnormal_cellular_cholesterol1.54687353
65MP0002332_abnormal_exercise_endurance1.51881249
66MP0006276_abnormal_autonomic_nervous1.51768174
67MP0005171_absent_coat_pigmentation1.51079722
68MP0003631_nervous_system_phenotype1.51037949
69MP0004947_skin_inflammation1.50799073
70MP0003632_abnormal_nervous_system1.49249014
71MP0004087_abnormal_muscle_fiber1.47883399
72MP0002882_abnormal_neuron_morphology1.47830203
73MP0003879_abnormal_hair_cell1.45119886
74MP0005501_abnormal_skin_physiology1.44141868
75MP0008004_abnormal_stomach_pH1.43697460
76MP0004924_abnormal_behavior1.43195553
77MP0005386_behavior/neurological_phenoty1.43195553
78MP0005409_darkened_coat_color1.42971772
79MP0005165_increased_susceptibility_to1.39205598
80MP0009780_abnormal_chondrocyte_physiolo1.38475800
81MP0003300_gastrointestinal_ulcer1.37981560
82MP0000759_abnormal_skeletal_muscle1.36428074
83MP0001299_abnormal_eye_distance/1.36131288
84MP0002066_abnormal_motor_capabilities/c1.35355294
85MP0002184_abnormal_innervation1.34039432
86MP0005620_abnormal_muscle_contractility1.33156018
87MP0002972_abnormal_cardiac_muscle1.30935433
88MP0004130_abnormal_muscle_cell1.30173336
89MP0004043_abnormal_pH_regulation1.28168230
90MP0005410_abnormal_fertilization1.27914982
91MP0005666_abnormal_adipose_tissue1.22004490
92MP0006138_congestive_heart_failure1.21648721
93MP0004185_abnormal_adipocyte_glucose1.20361438
94MP0004811_abnormal_neuron_physiology1.20262293
95MP0000465_gastrointestinal_hemorrhage1.19804667
96MP0002896_abnormal_bone_mineralization1.19195148
97MP0003828_pulmonary_edema1.18843037
98MP0010678_abnormal_skin_adnexa1.17815776
99MP0001216_abnormal_epidermal_layer1.16881582
100MP0000733_abnormal_muscle_development1.16568567
101MP0004484_altered_response_of1.15247940
102MP0005166_decreased_susceptibility_to1.12899368
103MP0005058_abnormal_lysosome_morphology1.11955389
104MP0002557_abnormal_social/conspecific_i1.11806237
105MP0001963_abnormal_hearing_physiology1.11026110
106MP0000462_abnormal_digestive_system1.10433171
107MP0002269_muscular_atrophy1.10033436
108MP0003136_yellow_coat_color1.09838697
109MP0010771_integument_phenotype1.09172844
110MP0000747_muscle_weakness1.08913855
111MP0000467_abnormal_esophagus_morphology1.06602396
112MP0005623_abnormal_meninges_morphology1.05783372
113MP0001879_abnormal_lymphatic_vessel1.05502261
114MP0005645_abnormal_hypothalamus_physiol1.03913074
115MP0000377_abnormal_hair_follicle1.03635365
116MP0005330_cardiomyopathy1.03444021
117MP0002752_abnormal_somatic_nervous1.01905620
118MP0005167_abnormal_blood-brain_barrier1.01039383
119MP0001765_abnormal_ion_homeostasis1.00974788
120MP0005551_abnormal_eye_electrophysiolog0.97888377
121MP0003656_abnormal_erythrocyte_physiolo0.96435886
122MP0001346_abnormal_lacrimal_gland0.94748416
123MP0000015_abnormal_ear_pigmentation0.94551168
124MP0005375_adipose_tissue_phenotype0.92626306
125MP0002106_abnormal_muscle_physiology0.92222927
126MP0001849_ear_inflammation0.91383796
127MP0003941_abnormal_skin_development0.90611744
128MP0001348_abnormal_lacrimal_gland0.90501720
129MP0010368_abnormal_lymphatic_system0.88187141
130MP0005646_abnormal_pituitary_gland0.88095126
131MP0002166_altered_tumor_susceptibility0.87751884
132MP0008260_abnormal_autophagy0.87287787
133MP0001502_abnormal_circadian_rhythm0.86008052
134MP0004134_abnormal_chest_morphology0.85007270
135MP0001661_extended_life_span0.84938680
136MP0001986_abnormal_taste_sensitivity0.82960249
137MP0001851_eye_inflammation0.81112754
138MP0000750_abnormal_muscle_regeneration0.80575762
139MP0002152_abnormal_brain_morphology0.80331137
140MP0000343_altered_response_to0.79803577
141MP0003075_altered_response_to0.79005045
142MP0004145_abnormal_muscle_electrophysio0.78663799
143MP0001177_atelectasis0.77800457
144MP0002168_other_aberrant_phenotype0.77766892
145MP0000537_abnormal_urethra_morphology0.75975405
146MP0000249_abnormal_blood_vessel0.75242228
147MP0000383_abnormal_hair_follicle0.74980109
148MP0001664_abnormal_digestion0.74355370
149MP0002909_abnormal_adrenal_gland0.73901324
150MP0009840_abnormal_foam_cell0.73156743
151MP0002006_tumorigenesis0.73065882
152MP0005499_abnormal_olfactory_system0.72934161
153MP0005394_taste/olfaction_phenotype0.72934161
154MP0005257_abnormal_intraocular_pressure0.72638801
155MP0008775_abnormal_heart_ventricle0.72387464
156MP0000013_abnormal_adipose_tissue0.72076178
157MP0002090_abnormal_vision0.72069702
158MP0000579_abnormal_nail_morphology0.67003757
159MP0000372_irregular_coat_pigmentation0.65392713
160MP0008874_decreased_physiological_sensi0.64737440
161MP0002295_abnormal_pulmonary_circulatio0.64069355
162MP0004381_abnormal_hair_follicle0.59890686
163MP0000647_abnormal_sebaceous_gland0.59018236
164MP0000762_abnormal_tongue_morphology0.58540217
165MP0008872_abnormal_physiological_respon0.57892574
166MP0000751_myopathy0.57281458
167MP0003183_abnormal_peptide_metabolism0.55983556
168MP0000003_abnormal_adipose_tissue0.54099213
169MP0002796_impaired_skin_barrier0.53731210

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.79056078
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.79056078
3Neurofibrillary tangles (HP:0002185)5.73942071
4Supranuclear gaze palsy (HP:0000605)5.08379670
5Myokymia (HP:0002411)5.03544119
6Abnormality of the corticospinal tract (HP:0002492)4.72430635
7Nemaline bodies (HP:0003798)4.53955748
8Peripheral hypomyelination (HP:0007182)4.41654658
9Insidious onset (HP:0003587)4.41436296
10Termporal pattern (HP:0011008)4.41436296
11Muscle fiber inclusion bodies (HP:0100299)4.41022921
12Cerebral inclusion bodies (HP:0100314)4.39169646
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.38559172
14Exercise-induced myalgia (HP:0003738)4.20072025
15Onion bulb formation (HP:0003383)4.01641450
16Ankle clonus (HP:0011448)3.91608980
17Action tremor (HP:0002345)3.70138143
18Focal motor seizures (HP:0011153)3.67336570
19Segmental peripheral demyelination/remyelination (HP:0003481)3.65128616
20Spastic gait (HP:0002064)3.64390483
21Parakeratosis (HP:0001036)3.59214606
22Type 1 muscle fiber predominance (HP:0003803)3.48198451
23Increased mean platelet volume (HP:0011877)3.47162154
24Sensory axonal neuropathy (HP:0003390)3.44943215
25Pheochromocytoma (HP:0002666)3.38736852
26Menorrhagia (HP:0000132)3.34894073
27Dysmetria (HP:0001310)3.34470032
28Intention tremor (HP:0002080)3.34342055
29Ulnar claw (HP:0001178)3.31292559
30Retinal dysplasia (HP:0007973)3.18904439
31Onycholysis (HP:0001806)3.14700544
32Atonic seizures (HP:0010819)3.11814670
33Distal lower limb muscle weakness (HP:0009053)3.08867236
34Abnormal platelet volume (HP:0011876)3.07505819
35Scanning speech (HP:0002168)3.06839603
36Atrophic scars (HP:0001075)3.04307489
37Neuroendocrine neoplasm (HP:0100634)2.97643252
38Focal seizures (HP:0007359)2.97470036
39Slow saccadic eye movements (HP:0000514)2.97395842
40Right ventricular cardiomyopathy (HP:0011663)2.92225701
41Abnormal auditory evoked potentials (HP:0006958)2.91810686
42Prolonged bleeding time (HP:0003010)2.90323518
43EMG: myopathic abnormalities (HP:0003458)2.89497826
44Distal lower limb amyotrophy (HP:0008944)2.85905255
45Exercise-induced muscle cramps (HP:0003710)2.84436932
46Cerebral hypomyelination (HP:0006808)2.83774437
47Increased connective tissue (HP:0009025)2.83504164
48Abnormality of skeletal muscle fiber size (HP:0012084)2.82980074
49Foot dorsiflexor weakness (HP:0009027)2.80928168
50Muscle fiber splitting (HP:0003555)2.79563631
51Bundle branch block (HP:0011710)2.79020953
52Abnormality of nail color (HP:0100643)2.77975725
53Akinesia (HP:0002304)2.75312620
54Centrally nucleated skeletal muscle fibers (HP:0003687)2.75176859
55Urinary urgency (HP:0000012)2.74730172
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.69284037
57Increased variability in muscle fiber diameter (HP:0003557)2.68905143
58Osteolytic defects of the hand bones (HP:0009699)2.66698071
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.66698071
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65842939
61Milia (HP:0001056)2.63556692
62Cerebral hemorrhage (HP:0001342)2.60953251
63Hammertoe (HP:0001765)2.53989671
64Lower limb muscle weakness (HP:0007340)2.53592109
65Abnormality of the foot musculature (HP:0001436)2.47157533
66Decreased motor nerve conduction velocity (HP:0003431)2.45976790
67Neck muscle weakness (HP:0000467)2.45873546
68Megalencephaly (HP:0001355)2.43993111
69Limb dystonia (HP:0002451)2.39752464
70Alacrima (HP:0000522)2.38444027
71Plantar hyperkeratosis (HP:0007556)2.38234833
72Lower limb amyotrophy (HP:0007210)2.34317586
73Epileptic encephalopathy (HP:0200134)2.33150274
74Visual hallucinations (HP:0002367)2.33074468
75Progressive cerebellar ataxia (HP:0002073)2.31214404
76Dialeptic seizures (HP:0011146)2.30833353
77Absence seizures (HP:0002121)2.30678874
78Distal sensory impairment (HP:0002936)2.29482847
79Petechiae (HP:0000967)2.29370689
80Aplasia involving bones of the upper limbs (HP:0009823)2.27884320
81Aplasia of the phalanges of the hand (HP:0009802)2.27884320
82Aplasia involving bones of the extremities (HP:0009825)2.27884320
83Autoamputation (HP:0001218)2.26563998
84Distal arthrogryposis (HP:0005684)2.24504939
85Rhabdomyolysis (HP:0003201)2.24452893
86Round ear (HP:0100830)2.23673603
87Premature rupture of membranes (HP:0001788)2.23473667
88Myoglobinuria (HP:0002913)2.23130898
89Axonal loss (HP:0003447)2.23115606
90Metabolic alkalosis (HP:0200114)2.22957644
91Truncal ataxia (HP:0002078)2.21725600
92Alopecia of scalp (HP:0002293)2.19708312
93Aortic aneurysm (HP:0004942)2.19688238
94Hypoplasia of the iris (HP:0007676)2.19093232
95Myopathic facies (HP:0002058)2.18576976
96Purpura (HP:0000979)2.18557476
97Difficulty running (HP:0009046)2.17895230
98Protrusio acetabuli (HP:0003179)2.16621114
99Popliteal pterygium (HP:0009756)2.15682736
100Increased circulating renin level (HP:0000848)2.14291706
101Arterial tortuosity (HP:0005116)2.13886996
102Congenital ichthyosiform erythroderma (HP:0007431)2.13305679
103Generalized tonic-clonic seizures (HP:0002069)2.13159423
104Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.12200151
105Thickened helices (HP:0000391)2.11510033
106Neuronal loss in central nervous system (HP:0002529)2.10962304
107Steppage gait (HP:0003376)2.10411984
108Clumsiness (HP:0002312)2.08802189
109Stridor (HP:0010307)2.07413953
110Spastic tetraparesis (HP:0001285)2.06853111
111Clonus (HP:0002169)2.06184849
112Gingival bleeding (HP:0000225)2.04767911
113Progressive inability to walk (HP:0002505)2.04064192
114Hyporeflexia of lower limbs (HP:0002600)2.03475130
115Urinary bladder sphincter dysfunction (HP:0002839)2.03005488
116Spinal rigidity (HP:0003306)2.02985459
117Mildly elevated creatine phosphokinase (HP:0008180)2.00776294
118Muscle hypertrophy of the lower extremities (HP:0008968)1.99686521
119Morphological abnormality of the pyramidal tract (HP:0002062)1.99602734
120Epistaxis (HP:0000421)1.97947407
121Fragile skin (HP:0001030)1.97903698
122Anxiety (HP:0000739)1.97799107
123Leukodystrophy (HP:0002415)1.97418326
124Vascular tortuosity (HP:0004948)1.96361581
125Dysdiadochokinesis (HP:0002075)1.96303772
126Ventricular tachycardia (HP:0004756)1.96209349
127Impaired platelet aggregation (HP:0003540)1.95649771
128Abnormal platelet function (HP:0011869)1.95649771
129Humeroradial synostosis (HP:0003041)1.94404370
130Synostosis involving the elbow (HP:0003938)1.94404370
131Calf muscle hypertrophy (HP:0008981)1.94275861
132Abnormal eating behavior (HP:0100738)1.94004709
133Thick nail (HP:0001805)1.91916866
134Obstructive sleep apnea (HP:0002870)1.89065306
135Aortic dissection (HP:0002647)1.88752001
136Abnormality of the calf musculature (HP:0001430)1.87955824
137Febrile seizures (HP:0002373)1.87487712
138Abnormal atrioventricular conduction (HP:0005150)1.87136844
139Bulbar palsy (HP:0001283)1.87109571
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86957780
141Mitral stenosis (HP:0001718)1.86674189
142CNS hypomyelination (HP:0003429)1.86401985
143Dysmetric saccades (HP:0000641)1.85068911
144Ankyloglossia (HP:0010296)1.85038233
145Mutism (HP:0002300)1.85031980
146Depression (HP:0000716)1.84888340
147Pili torti (HP:0003777)1.84818425
148Cerebral aneurysm (HP:0004944)1.83835548
149Rapidly progressive (HP:0003678)1.83646975
150Muscle stiffness (HP:0003552)1.83121279
151Split foot (HP:0001839)1.82800325
152Morphological abnormality of the inner ear (HP:0011390)1.82327687
153Postural instability (HP:0002172)1.81941900
154Hypomagnesemia (HP:0002917)1.81245648
155Sudden death (HP:0001699)1.80505813
156Hyperphosphatemia (HP:0002905)1.79997677
157Abnormality of saccadic eye movements (HP:0000570)1.79720220
158Palmoplantar hyperkeratosis (HP:0000972)1.79005577
159Fragile nails (HP:0001808)1.78028808
160Abnormality of the left ventricular outflow tract (HP:0011103)1.77364345
161Subaortic stenosis (HP:0001682)1.77364345
162Peripheral demyelination (HP:0011096)1.76682396
163Wormian bones (HP:0002645)1.76144975
164Advanced eruption of teeth (HP:0006288)1.75857923
165Decreased lacrimation (HP:0000633)1.75641223
166Reduced subcutaneous adipose tissue (HP:0003758)1.75437096
167Cardiovascular calcification (HP:0011915)1.75011279
168Hypokalemic alkalosis (HP:0001949)1.74492975
169Urinary incontinence (HP:0000020)1.74164005
170Asymmetric septal hypertrophy (HP:0001670)1.73890400
171Diaphragmatic weakness (HP:0009113)1.73742215
172Nail dystrophy (HP:0008404)1.73414904
173Ridged nail (HP:0001807)1.72872461
174Type II lissencephaly (HP:0007260)1.72459724
175Psychosis (HP:0000709)1.72087513
176Generalized myoclonic seizures (HP:0002123)1.71842000
177Rigidity (HP:0002063)1.71798421
178Paralysis (HP:0003470)1.71430907
179Abnormality of the middle phalanges of the toes (HP:0010183)1.70783428
180Torticollis (HP:0000473)1.70737975
181Poor speech (HP:0002465)1.70688746
182Anteriorly placed anus (HP:0001545)1.70326210
183Scapular winging (HP:0003691)1.69771636
184Overgrowth (HP:0001548)1.68864948
185Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65853896
186Abnormal blistering of the skin (HP:0008066)1.64026238
187Insomnia (HP:0100785)1.63919354
188Abnormality of the Achilles tendon (HP:0005109)1.61801144
189Heart block (HP:0012722)1.61625373
190Back pain (HP:0003418)1.61542031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.37947802
2OXSR13.50349390
3OBSCN2.90759696
4MAPKAPK52.63380693
5WNK12.50768255
6EPHB12.47904840
7NTRK12.47887255
8TTN2.42458007
9WNK42.41551973
10RIPK12.37691055
11LIMK12.34158209
12EPHA22.18029907
13MYLK2.15589519
14EEF2K2.08222766
15MAP3K92.07462641
16CDK192.00375234
17KSR21.98998915
18NTRK31.98704330
19BCR1.90572901
20MAPKAPK31.88583597
21AKT31.85608040
22PKN11.80933420
23PAK61.76920330
24EIF2AK11.72388079
25MAP3K31.70118020
26MET1.69536644
27UHMK11.66597910
28TRIB31.64371512
29MINK11.64149999
30PBK1.57657446
31LATS21.56438376
32MAP3K21.55967532
33MST41.49255487
34MARK11.48801998
35ROCK21.45405544
36NEK91.45254287
37CAMK2B1.44272937
38BMX1.43916607
39PDGFRA1.42655070
40ARAF1.42024541
41LMTK21.41457797
42SGK2231.39106642
43SGK4941.39106642
44BMPR21.37266857
45FGFR21.37181515
46PNCK1.36830517
47EPHA41.34113214
48PAK31.33412630
49PTK21.32104331
50PHKG21.31741877
51PHKG11.31741877
52TNIK1.29700452
53CAMK2D1.27707337
54CDK51.25459890
55SCYL21.24861052
56CSNK1G31.23643981
57CSNK1G21.22585715
58MAP3K41.20739044
59CASK1.20032948
60MAPK121.19966501
61SIK11.17555761
62TESK11.17380543
63CAMK2G1.14474955
64CSNK1A1L1.12980990
65PIK3CG1.07665243
66NEK61.04653331
67ILK1.03936436
68CDK141.03198879
69FGR1.01565536
70SGK31.01136871
71STK380.98799024
72MOS0.94889005
73CAMK2A0.93488105
74PIM20.90884520
75CDK150.90822165
76GRK50.90090934
77PRPF4B0.89448601
78ERN10.88230459
79MAP2K70.87779577
80CDK180.87272022
81PRKD30.85398761
82PRKCH0.85061351
83STK240.84784867
84TAOK20.84526381
85PTK2B0.84442956
86MAPK130.83720380
87CSNK1G10.82455813
88MAP3K130.81838617
89MAP2K20.80807511
90PDPK10.79689813
91NTRK20.79048408
92PDGFRB0.78957228
93SGK20.78157289
94JAK10.78148417
95CDK11A0.77936031
96PAK40.77562713
97CAMK1G0.76724241
98PRKCE0.76662252
99PAK20.76560483
100TYRO30.76175044
101RET0.73910921
102PRKD10.73835314
103MAP2K30.72952078
104MARK20.72489814
105MAP3K120.70138900
106DAPK30.69135674
107PRKD20.68057919
108DAPK20.67558245
109MAP3K10.65534633
110PRKCQ0.65182800
111MST1R0.64024380
112STK110.62330964
113CLK10.61801431
114TESK20.61722876
115RAF10.61582786
116SMG10.61549959
117LATS10.60283771
118FYN0.59959529
119MAPK150.59008543
120EPHB20.58471586
121FER0.58005725
122MAP2K40.57536188
123IRAK30.56932776
124ICK0.56873509
125MAP2K10.56320915
126PIK3CA0.55879934
127MUSK0.55640917
128FES0.54715240
129TRPM70.53931999
130GRK70.53759786
131TNK20.52197401
132CAMK1D0.52158905
133DMPK0.48722446
134PDK10.48505044
135CAMKK20.48017269
136TAOK10.46650048
137PRKCG0.46470275
138CAMKK10.45860634
139CSNK1A10.45809845
140AKT20.44758868
141MTOR0.43380876
142PLK20.42821417
143BRAF0.41945745
144TGFBR20.41556617
145RIPK40.41472335
146ROCK10.41004135
147EPHA30.40991700
148ZAP700.40832372
149PRKAA20.39983403
150KSR10.39763936
151HIPK20.39592873
152PRKG10.39581469
153BMPR1B0.36872759
154DYRK20.36726183
155PRKACB0.36597779
156DDR20.34558757

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.18811544
2Steroid biosynthesis_Homo sapiens_hsa001002.53007532
3ECM-receptor interaction_Homo sapiens_hsa045122.34256190
4Fatty acid elongation_Homo sapiens_hsa000622.33342380
5Synaptic vesicle cycle_Homo sapiens_hsa047212.25854126
6Olfactory transduction_Homo sapiens_hsa047402.07505987
7Platelet activation_Homo sapiens_hsa046111.96551525
8Ether lipid metabolism_Homo sapiens_hsa005651.95097713
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.93396216
10GABAergic synapse_Homo sapiens_hsa047271.90995206
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86467912
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79061567
13Focal adhesion_Homo sapiens_hsa045101.77596278
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74392092
15Glutamatergic synapse_Homo sapiens_hsa047241.74049969
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72346653
17Salivary secretion_Homo sapiens_hsa049701.70376009
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69433790
19Nicotine addiction_Homo sapiens_hsa050331.66229789
20Collecting duct acid secretion_Homo sapiens_hsa049661.64434742
21Morphine addiction_Homo sapiens_hsa050321.62510814
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61992783
23Circadian entrainment_Homo sapiens_hsa047131.59853764
24Gastric acid secretion_Homo sapiens_hsa049711.59127681
25Serotonergic synapse_Homo sapiens_hsa047261.55230002
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53011790
27Sulfur metabolism_Homo sapiens_hsa009201.51612975
28Axon guidance_Homo sapiens_hsa043601.49517373
29Vibrio cholerae infection_Homo sapiens_hsa051101.48409254
30Dopaminergic synapse_Homo sapiens_hsa047281.44410562
31Oxidative phosphorylation_Homo sapiens_hsa001901.39550883
32Long-term depression_Homo sapiens_hsa047301.38404281
33Sphingolipid metabolism_Homo sapiens_hsa006001.34986642
34Adherens junction_Homo sapiens_hsa045201.34639248
35Long-term potentiation_Homo sapiens_hsa047201.33315865
36Cholinergic synapse_Homo sapiens_hsa047251.30757959
37Dorso-ventral axis formation_Homo sapiens_hsa043201.24917926
38Arginine and proline metabolism_Homo sapiens_hsa003301.24096094
39Circadian rhythm_Homo sapiens_hsa047101.22132004
40Taste transduction_Homo sapiens_hsa047421.21673322
41Amphetamine addiction_Homo sapiens_hsa050311.21015602
42Cocaine addiction_Homo sapiens_hsa050301.20865369
43Nitrogen metabolism_Homo sapiens_hsa009101.19875178
44Amoebiasis_Homo sapiens_hsa051461.18162026
45Endometrial cancer_Homo sapiens_hsa052131.17934483
46Fatty acid biosynthesis_Homo sapiens_hsa000611.17713195
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16812365
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15860236
49Small cell lung cancer_Homo sapiens_hsa052221.14590673
50Insulin secretion_Homo sapiens_hsa049111.12314821
51Insulin signaling pathway_Homo sapiens_hsa049101.12041987
52Alzheimers disease_Homo sapiens_hsa050101.11440809
53Renin secretion_Homo sapiens_hsa049241.11431392
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08746013
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08007951
56Pancreatic cancer_Homo sapiens_hsa052121.07389629
57Mineral absorption_Homo sapiens_hsa049781.07300042
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05558496
59Parkinsons disease_Homo sapiens_hsa050121.05469038
60VEGF signaling pathway_Homo sapiens_hsa043701.05221270
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05063447
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04167884
63SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03915149
64Gap junction_Homo sapiens_hsa045401.03841644
65Leukocyte transendothelial migration_Homo sapiens_hsa046701.03435414
66Sphingolipid signaling pathway_Homo sapiens_hsa040711.02638240
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01827286
68Proteoglycans in cancer_Homo sapiens_hsa052051.01210240
69Renal cell carcinoma_Homo sapiens_hsa052111.00426110
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98973928
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98674025
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98673552
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.97524356
74Non-small cell lung cancer_Homo sapiens_hsa052230.97258624
75Pancreatic secretion_Homo sapiens_hsa049720.96828066
76GnRH signaling pathway_Homo sapiens_hsa049120.96233243
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94148542
78Endocytosis_Homo sapiens_hsa041440.93952240
79ErbB signaling pathway_Homo sapiens_hsa040120.91670413
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88935456
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88786070
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88734629
83Cardiac muscle contraction_Homo sapiens_hsa042600.88495227
84Thyroid cancer_Homo sapiens_hsa052160.88134402
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.87061722
86Glucagon signaling pathway_Homo sapiens_hsa049220.86462830
87Tight junction_Homo sapiens_hsa045300.86027074
88AMPK signaling pathway_Homo sapiens_hsa041520.85942911
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.85239919
90Oxytocin signaling pathway_Homo sapiens_hsa049210.84780433
91cAMP signaling pathway_Homo sapiens_hsa040240.84217777
92Insulin resistance_Homo sapiens_hsa049310.82963726
93Chronic myeloid leukemia_Homo sapiens_hsa052200.80347317
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79782411
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79656623
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77839659
97Calcium signaling pathway_Homo sapiens_hsa040200.77751953
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77476847
99mTOR signaling pathway_Homo sapiens_hsa041500.75630199
100Ras signaling pathway_Homo sapiens_hsa040140.74731511
101Phototransduction_Homo sapiens_hsa047440.73957708
102Rheumatoid arthritis_Homo sapiens_hsa053230.73091188
103Lysosome_Homo sapiens_hsa041420.72994089
104Linoleic acid metabolism_Homo sapiens_hsa005910.71810133
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71640308
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71172847
107Prostate cancer_Homo sapiens_hsa052150.71141701
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.71105755
109Estrogen signaling pathway_Homo sapiens_hsa049150.70400573
110Phagosome_Homo sapiens_hsa041450.69078962
111Histidine metabolism_Homo sapiens_hsa003400.66994681
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65824483
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65587674
114Thyroid hormone synthesis_Homo sapiens_hsa049180.65555483
115Melanogenesis_Homo sapiens_hsa049160.65253901
116Ovarian steroidogenesis_Homo sapiens_hsa049130.61184528
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.60146422
118Butanoate metabolism_Homo sapiens_hsa006500.59745699
119Salmonella infection_Homo sapiens_hsa051320.59087113
120Renin-angiotensin system_Homo sapiens_hsa046140.57222389
121Choline metabolism in cancer_Homo sapiens_hsa052310.56496294
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.54724753
123Bladder cancer_Homo sapiens_hsa052190.54575477
124Fructose and mannose metabolism_Homo sapiens_hsa000510.54384033
125Glioma_Homo sapiens_hsa052140.54059247
126beta-Alanine metabolism_Homo sapiens_hsa004100.53864627
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53850264
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53307057
129Vitamin B6 metabolism_Homo sapiens_hsa007500.52846163
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52076956
131Arginine biosynthesis_Homo sapiens_hsa002200.51974173
132Pentose phosphate pathway_Homo sapiens_hsa000300.51684929
133HIF-1 signaling pathway_Homo sapiens_hsa040660.51263430
134B cell receptor signaling pathway_Homo sapiens_hsa046620.50398885
135Toxoplasmosis_Homo sapiens_hsa051450.50297681
136Hepatitis C_Homo sapiens_hsa051600.50094993
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49813167
138Shigellosis_Homo sapiens_hsa051310.48659685
139MAPK signaling pathway_Homo sapiens_hsa040100.47428937
140Inositol phosphate metabolism_Homo sapiens_hsa005620.45315322
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45198538
142Rap1 signaling pathway_Homo sapiens_hsa040150.44691791
143Protein export_Homo sapiens_hsa030600.43880412
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43431826
145Bile secretion_Homo sapiens_hsa049760.43315634
146Alcoholism_Homo sapiens_hsa050340.42505519
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41700460
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41549611
149Prion diseases_Homo sapiens_hsa050200.41142868
150Dilated cardiomyopathy_Homo sapiens_hsa054140.40924645

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