ENDOG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)7.36993822
2actin-myosin filament sliding (GO:0033275)7.36993822
3skeletal muscle contraction (GO:0003009)6.73094840
4L-phenylalanine metabolic process (GO:0006558)6.47110292
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.47110292
6L-phenylalanine catabolic process (GO:0006559)6.28984663
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.28984663
8sarcoplasmic reticulum calcium ion transport (GO:0070296)6.08922980
9regulation of skeletal muscle contraction (GO:0014819)5.85832735
10aromatic amino acid family catabolic process (GO:0009074)5.83226311
11actin-mediated cell contraction (GO:0070252)5.75018696
12kynurenine metabolic process (GO:0070189)5.66002629
13creatine metabolic process (GO:0006600)5.54259262
14glyoxylate metabolic process (GO:0046487)5.46596609
15tryptophan catabolic process (GO:0006569)5.41656047
16indole-containing compound catabolic process (GO:0042436)5.41656047
17indolalkylamine catabolic process (GO:0046218)5.41656047
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.28222284
19lysine catabolic process (GO:0006554)4.99146912
20lysine metabolic process (GO:0006553)4.99146912
21cysteine metabolic process (GO:0006534)4.97651578
22striated muscle contraction (GO:0006941)4.95160309
23tryptophan metabolic process (GO:0006568)4.93088359
24bile acid biosynthetic process (GO:0006699)4.90660353
25serine family amino acid catabolic process (GO:0009071)4.89738641
26sulfur amino acid catabolic process (GO:0000098)4.87030510
27negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.82808631
28glycine metabolic process (GO:0006544)4.64691545
29gluconeogenesis (GO:0006094)4.52670058
30regulation of triglyceride catabolic process (GO:0010896)4.49006838
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.41819989
322-oxoglutarate metabolic process (GO:0006103)4.40909793
33sarcomere organization (GO:0045214)4.40275190
34amino-acid betaine metabolic process (GO:0006577)4.40129864
35aromatic amino acid family metabolic process (GO:0009072)4.37734231
36negative regulation of fibrinolysis (GO:0051918)4.36774407
37alpha-amino acid catabolic process (GO:1901606)4.36499103
38serine family amino acid metabolic process (GO:0009069)4.34445503
39coenzyme catabolic process (GO:0009109)4.33910569
40urea metabolic process (GO:0019627)4.30267590
41urea cycle (GO:0000050)4.30267590
42alpha-linolenic acid metabolic process (GO:0036109)4.29272173
43cellular ketone body metabolic process (GO:0046950)4.29028374
44serine family amino acid biosynthetic process (GO:0009070)4.25418861
45skeletal muscle fiber development (GO:0048741)4.20623823
46regulation of fibrinolysis (GO:0051917)4.20418812
47high-density lipoprotein particle remodeling (GO:0034375)4.19350152
48hexose biosynthetic process (GO:0019319)4.18487920
49nitrogen cycle metabolic process (GO:0071941)4.17421206
50cellular amino acid catabolic process (GO:0009063)4.11886304
51response to muscle activity (GO:0014850)4.09648769
52regulation of protein activation cascade (GO:2000257)4.09504151
53actin filament-based movement (GO:0030048)4.09292089
54acetyl-CoA metabolic process (GO:0006084)4.07828155
55cardiac muscle contraction (GO:0060048)4.07711615
56fatty acid beta-oxidation (GO:0006635)4.07688045
57bile acid metabolic process (GO:0008206)4.06543130
58peptidyl-glutamic acid carboxylation (GO:0017187)4.05103343
59protein carboxylation (GO:0018214)4.05103343
60monosaccharide biosynthetic process (GO:0046364)4.04784871
61short-chain fatty acid metabolic process (GO:0046459)4.04150989
62homocysteine metabolic process (GO:0050667)4.03014481
63aspartate family amino acid catabolic process (GO:0009068)4.00958215
64response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.97313662
65proline biosynthetic process (GO:0006561)3.95607908
66complement activation, alternative pathway (GO:0006957)3.95154652
67acylglycerol homeostasis (GO:0055090)3.93733146
68triglyceride homeostasis (GO:0070328)3.93733146
69oxidative phosphorylation (GO:0006119)3.93557022
70branched-chain amino acid catabolic process (GO:0009083)3.89906419
71glucan biosynthetic process (GO:0009250)3.88957926
72glycogen biosynthetic process (GO:0005978)3.88957926
73ethanol oxidation (GO:0006069)3.88496360
74fructose metabolic process (GO:0006000)3.86459949
75protein insertion into membrane (GO:0051205)3.86303740
76fatty acid catabolic process (GO:0009062)3.85440891
77cellular modified amino acid catabolic process (GO:0042219)3.83299070
78regulation of complement activation (GO:0030449)3.82956206
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.81643380
80fatty acid oxidation (GO:0019395)3.80853041
81regulation of cholesterol esterification (GO:0010872)3.80122091
82carboxylic acid catabolic process (GO:0046395)3.78943148
83organic acid catabolic process (GO:0016054)3.78943148
84glutamate metabolic process (GO:0006536)3.78755705
85negative regulation of cholesterol transport (GO:0032375)3.75302779
86negative regulation of sterol transport (GO:0032372)3.75302779
87protein-lipid complex remodeling (GO:0034368)3.72234874
88macromolecular complex remodeling (GO:0034367)3.72234874
89plasma lipoprotein particle remodeling (GO:0034369)3.72234874
90lipid oxidation (GO:0034440)3.72173396
91monocarboxylic acid catabolic process (GO:0072329)3.71660466
92ketone body metabolic process (GO:1902224)3.67609682
93dicarboxylic acid biosynthetic process (GO:0043650)3.67043019
94myofibril assembly (GO:0030239)3.65309105
95L-serine metabolic process (GO:0006563)3.64429934
96indolalkylamine metabolic process (GO:0006586)3.63129316
97regulation of relaxation of muscle (GO:1901077)3.62379475
98glycogen catabolic process (GO:0005980)3.59996995
99reverse cholesterol transport (GO:0043691)3.58927079
100valine metabolic process (GO:0006573)3.58868279
101branched-chain amino acid metabolic process (GO:0009081)3.58233447
102cellular biogenic amine catabolic process (GO:0042402)3.55672948
103amine catabolic process (GO:0009310)3.55672948
104benzene-containing compound metabolic process (GO:0042537)3.55105680
105biotin metabolic process (GO:0006768)3.54852442
106carnitine metabolic process (GO:0009437)3.52571295
107myotube cell development (GO:0014904)3.52242486
108tyrosine metabolic process (GO:0006570)3.50244320
109positive regulation of triglyceride lipase activity (GO:0061365)3.49495095
110positive regulation of lipoprotein lipase activity (GO:0051006)3.49495095
111plasma lipoprotein particle clearance (GO:0034381)3.44563322
112bile acid and bile salt transport (GO:0015721)3.43895252
113muscle contraction (GO:0006936)3.43596069
114cofactor catabolic process (GO:0051187)3.41401602
115fatty acid transmembrane transport (GO:1902001)3.40916411
116mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40870021
117phospholipid efflux (GO:0033700)3.40287825
118blood coagulation, intrinsic pathway (GO:0007597)3.39874295
119oxaloacetate metabolic process (GO:0006107)3.38754613
120aldehyde catabolic process (GO:0046185)3.38745796
121NAD biosynthetic process (GO:0009435)3.36600895
122skeletal muscle adaptation (GO:0043501)3.34326196
123muscle organ morphogenesis (GO:0048644)3.32419150
124imidazole-containing compound metabolic process (GO:0052803)3.30769134
125NADH metabolic process (GO:0006734)3.29289897
126arginine metabolic process (GO:0006525)3.28781359
127glucan catabolic process (GO:0009251)3.27900537
128tricarboxylic acid cycle (GO:0006099)3.27368122
129flavonoid metabolic process (GO:0009812)3.26229023
130NAD metabolic process (GO:0019674)3.25524925
131carnitine shuttle (GO:0006853)3.25330499
132mitochondrial fusion (GO:0008053)3.24180093
133small molecule catabolic process (GO:0044282)3.23397122
134dicarboxylic acid metabolic process (GO:0043648)3.21556423
135viral transcription (GO:0019083)3.19104227
136regulation of translational fidelity (GO:0006450)3.17805062
137ribosomal small subunit biogenesis (GO:0042274)3.17415270
138peptidyl-arginine omega-N-methylation (GO:0035247)3.17365463
139regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.15515441
140ubiquinone biosynthetic process (GO:0006744)3.13180689
141motile cilium assembly (GO:0044458)3.12542114
142proline metabolic process (GO:0006560)3.11251352
143muscle cell cellular homeostasis (GO:0046716)3.05665877
144negative regulation of cell size (GO:0045792)3.02893882
145regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.01786341
146glycolytic process (GO:0006096)2.98661462
147muscle system process (GO:0003012)2.97492546
148cellular polysaccharide catabolic process (GO:0044247)2.96776188
149respiratory electron transport chain (GO:0022904)2.95453640
150muscle cell fate commitment (GO:0042693)2.94581967
151electron transport chain (GO:0022900)2.93107029
152regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91420018
153cardiac myofibril assembly (GO:0055003)2.89657300
154positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.89602679
155glucose metabolic process (GO:0006006)2.85149889
156heart process (GO:0003015)2.83419198
157heart contraction (GO:0060047)2.83419198
158translational termination (GO:0006415)2.83408898
159glycogen metabolic process (GO:0005977)2.82105723
160tricarboxylic acid metabolic process (GO:0072350)2.81298316
161translational elongation (GO:0006414)2.81257080
162positive regulation of myotube differentiation (GO:0010831)2.80483767
163actomyosin structure organization (GO:0031032)2.80360759
164negative regulation of potassium ion transmembrane transport (GO:1901380)2.79923281
1654-hydroxyproline metabolic process (GO:0019471)2.77236672
166response to inactivity (GO:0014854)2.74036683
167glucan metabolic process (GO:0044042)2.73240033
168cellular glucan metabolic process (GO:0006073)2.73240033
169GDP-mannose metabolic process (GO:0019673)2.73189279
170pentose-phosphate shunt (GO:0006098)2.72900348
171quinone biosynthetic process (GO:1901663)2.72406978
172nucleobase-containing small molecule interconversion (GO:0015949)2.71898828
173positive regulation of synapse maturation (GO:0090129)2.71681598
174carbohydrate biosynthetic process (GO:0016051)2.70973623
175axonemal dynein complex assembly (GO:0070286)2.70459575
176muscle fiber development (GO:0048747)2.62370257
177retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61741025
178polysaccharide catabolic process (GO:0000272)2.61251033
179negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.61096432
180ubiquinone metabolic process (GO:0006743)2.60633665
181regulation of actin filament-based movement (GO:1903115)2.59129751
182galactose catabolic process (GO:0019388)2.58974262
183regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57917910
184peptidyl-arginine methylation (GO:0018216)2.56401365
185peptidyl-arginine N-methylation (GO:0035246)2.56401365
186nucleotide salvage (GO:0043173)2.56099834
187muscle tissue morphogenesis (GO:0060415)2.53642140
188skeletal muscle tissue development (GO:0007519)2.51601723
189nucleoside diphosphate biosynthetic process (GO:0009133)2.47847307
190regulation of cell communication by electrical coupling (GO:0010649)2.46326516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.48456728
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.39008859
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.35889185
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.62587181
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.67583482
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.56590754
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.18497196
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.91509909
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.43299988
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.00551758
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.68419843
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.67244871
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65295936
14VDR_21846776_ChIP-Seq_THP-1_Human2.60555047
15* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.53991313
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.28737408
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89974942
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.88322071
19ZNF263_19887448_ChIP-Seq_K562_Human1.87771644
20MYC_22102868_ChIP-Seq_BL_Human1.83436495
21ERG_21242973_ChIP-ChIP_JURKAT_Human1.75135535
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.73769448
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72200789
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70996565
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69167242
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68137789
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62391189
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.62224430
29* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59335921
30CTCF_27219007_Chip-Seq_Bcells_Human1.58335641
31CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57112587
32NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55792661
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55162976
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54362199
35* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53785284
36* SMC4_20622854_ChIP-Seq_HELA_Human1.51766893
37KDM2B_26808549_Chip-Seq_DND41_Human1.46870390
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44108521
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.44102611
40CREB1_26743006_Chip-Seq_LNCaP_Human1.41352326
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.40808350
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40245103
43CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39858864
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.39443656
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38923148
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37808292
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36714746
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35910330
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34834732
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34347083
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33457956
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33014418
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31868680
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28729594
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28674767
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.28247819
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26471327
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.26211498
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24364451
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19841664
61CLOCK_20551151_ChIP-Seq_293T_Human1.19318469
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19285597
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18785255
64SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.18698426
65KDM2B_26808549_Chip-Seq_K562_Human1.17683775
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17294995
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15004949
68* TCF7_22412390_ChIP-Seq_EML_Mouse1.14950645
69* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14689441
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.13213364
71LXR_22292898_ChIP-Seq_THP-1_Human1.11441696
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11437519
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10496425
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09632034
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09399611
76ETS1_21867929_ChIP-Seq_TH2_Mouse1.09202584
77ATF3_27146783_Chip-Seq_COLON_Human1.08108476
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07977943
79* TET1_21451524_ChIP-Seq_MESCs_Mouse1.07777451
80SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07135978
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06369206
82* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06149868
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05814497
84GATA1_22025678_ChIP-Seq_K562_Human1.05107742
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04780740
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.04693210
87XRN2_22483619_ChIP-Seq_HELA_Human0.98936432
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96825263
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96565705
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96214595
91HNF4A_19822575_ChIP-Seq_HepG2_Human0.92069571
92MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91784728
93P68_20966046_ChIP-Seq_HELA_Human0.91585395
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.91269459
95HTT_18923047_ChIP-ChIP_STHdh_Human0.91037397
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90627172
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90483755
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88534514
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88346034
100DCP1A_22483619_ChIP-Seq_HELA_Human0.87688105
101* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87048687
102BCOR_27268052_Chip-Seq_Bcells_Human0.86498855
103BCL6_27268052_Chip-Seq_Bcells_Human0.86098652
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86051684
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85311775
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85183550
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84953451
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.83252778
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82965291
110* GABP_19822575_ChIP-Seq_HepG2_Human0.82786813
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82773716
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82427254
113CTCF_26484167_Chip-Seq_Bcells_Mouse0.82307502
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81471494
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81055464
116RARB_24833708_ChIP-Seq_LIVER_Mouse0.80577281
117CTCF_21964334_Chip-Seq_Bcells_Human0.80217787
118FOXP1_21924763_ChIP-Seq_HESCs_Human0.77266658
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.75735211
120SA1_27219007_Chip-Seq_Bcells_Human0.74387901
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74341647
122* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.73563670
123* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72883395
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72790742
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72779675
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72181914
127SA1_27219007_Chip-Seq_ERYTHROID_Human0.71033417
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70165684
129ERA_21632823_ChIP-Seq_H3396_Human0.69997692
130E2F1_20622854_ChIP-Seq_HELA_Human0.69938548
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.68839498
132PHF8_20622854_ChIP-Seq_HELA_Human0.68068048
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.66829001
134TAF2_19829295_ChIP-Seq_ESCs_Human0.66418024
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.66098742
136FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.65839647
137SPI1_20517297_ChIP-Seq_HL60_Human0.64786797
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.63898785
139CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63817171
140RACK7_27058665_Chip-Seq_MCF-7_Human0.62547644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.96397589
2MP0005360_urolithiasis6.61976367
3MP0005085_abnormal_gallbladder_physiolo5.51746373
4MP0005365_abnormal_bile_salt5.32616815
5MP0003806_abnormal_nucleotide_metabolis4.37114572
6MP0008875_abnormal_xenobiotic_pharmacok4.13572214
7MP0009840_abnormal_foam_cell3.70290882
8MP0004233_abnormal_muscle_weight3.55645679
9MP0010329_abnormal_lipoprotein_level3.04722621
10MP0005332_abnormal_amino_acid2.92650557
11MP0005083_abnormal_biliary_tract2.85163300
12MP0003646_muscle_fatigue2.79626199
13MP0003252_abnormal_bile_duct2.76375290
14MP0003195_calcinosis2.71216347
15MP0001666_abnormal_nutrient_absorption2.55575879
16MP0002837_dystrophic_cardiac_calcinosis2.54906631
17MP0006036_abnormal_mitochondrial_physio2.32443423
18MP0003191_abnormal_cellular_cholesterol2.29729224
19MP0005369_muscle_phenotype2.24357934
20MP0000733_abnormal_muscle_development2.03079076
21MP0004019_abnormal_vitamin_homeostasis2.00166341
22MP0002118_abnormal_lipid_homeostasis1.96702276
23MP0005319_abnormal_enzyme/_coenzyme1.93179273
24MP0003868_abnormal_feces_composition1.88024077
25MP0000609_abnormal_liver_physiology1.85507434
26MP0002822_catalepsy1.74550866
27MP0000013_abnormal_adipose_tissue1.72134043
28MP0000003_abnormal_adipose_tissue1.59606449
29MP0005584_abnormal_enzyme/coenzyme_acti1.56211336
30MP0004130_abnormal_muscle_cell1.54229580
31MP0005330_cardiomyopathy1.53328831
32MP0003186_abnormal_redox_activity1.51043004
33MP0000751_myopathy1.49724725
34MP0001764_abnormal_homeostasis1.48885632
35MP0006035_abnormal_mitochondrial_morpho1.48812458
36MP0009643_abnormal_urine_homeostasis1.46722241
37MP0005451_abnormal_body_composition1.45199319
38MP0005375_adipose_tissue_phenotype1.43428431
39MP0002138_abnormal_hepatobiliary_system1.39478280
40MP0000749_muscle_degeneration1.34703015
41MP0004270_analgesia1.32563034
42MP0004036_abnormal_muscle_relaxation1.31411033
43MP0001346_abnormal_lacrimal_gland1.29139293
44MP0005058_abnormal_lysosome_morphology1.28619983
45MP0002269_muscular_atrophy1.24933831
46MP0005670_abnormal_white_adipose1.22570416
47MP0003879_abnormal_hair_cell1.22086239
48MP0005623_abnormal_meninges_morphology1.21413301
49MP0004510_myositis1.20353508
50MP0002249_abnormal_larynx_morphology1.20301012
51MP0004084_abnormal_cardiac_muscle1.19541915
52MP0005266_abnormal_metabolism1.19291902
53MP0004215_abnormal_myocardial_fiber1.13575949
54MP0002108_abnormal_muscle_morphology1.12933354
55MP0003011_delayed_dark_adaptation1.12443787
56MP0005084_abnormal_gallbladder_morpholo1.12304448
57MP0000678_abnormal_parathyroid_gland1.11029370
58MP0004858_abnormal_nervous_system1.10736442
59MP0005636_abnormal_mineral_homeostasis1.08652894
60MP0000747_muscle_weakness1.08154399
61MP0005647_abnormal_sex_gland1.05675074
62MP0005409_darkened_coat_color1.02350357
63MP0000598_abnormal_liver_morphology1.02063182
64MP0003656_abnormal_erythrocyte_physiolo1.01944300
65MP0002078_abnormal_glucose_homeostasis0.99782958
66MP0010030_abnormal_orbit_morphology0.99480927
67MP0004484_altered_response_of0.95907841
68MP0005666_abnormal_adipose_tissue0.94824613
69MP0003137_abnormal_impulse_conducting0.92707162
70MP0009642_abnormal_blood_homeostasis0.91492884
71MP0005376_homeostasis/metabolism_phenot0.89799101
72MP0005423_abnormal_somatic_nervous0.89444367
73MP0002971_abnormal_brown_adipose0.89147284
74MP0002132_abnormal_respiratory_system0.86777689
75MP0003221_abnormal_cardiomyocyte_apopto0.85152861
76MP0004087_abnormal_muscle_fiber0.84972886
77MP0008469_abnormal_protein_level0.84813776
78MP0000604_amyloidosis0.82494088
79MP0002332_abnormal_exercise_endurance0.81609291
80MP0009697_abnormal_copulation0.80466056
81MP0000750_abnormal_muscle_regeneration0.79031672
82MP0005535_abnormal_body_temperature0.78970232
83MP0003718_maternal_effect0.78838528
84MP0009763_increased_sensitivity_to0.77885788
85MP0002127_abnormal_cardiovascular_syste0.77677760
86MP0001544_abnormal_cardiovascular_syste0.76903137
87MP0005385_cardiovascular_system_phenoty0.76903137
88MP0001756_abnormal_urination0.76126034
89MP0005076_abnormal_cell_differentiation0.73410808
90MP0003329_amyloid_beta_deposits0.71718454
91MP0001529_abnormal_vocalization0.71706500
92MP0009333_abnormal_splenocyte_physiolog0.71692623
93MP0002972_abnormal_cardiac_muscle0.71076487
94MP0000343_altered_response_to0.70455620
95MP0008260_abnormal_autophagy0.70105086
96MP0005620_abnormal_muscle_contractility0.69496931
97MP0005334_abnormal_fat_pad0.69043590
98MP0005220_abnormal_exocrine_pancreas0.68622434
99MP0002909_abnormal_adrenal_gland0.68419093
100MP0004043_abnormal_pH_regulation0.67692195
101MP0010630_abnormal_cardiac_muscle0.67500283
102MP0005501_abnormal_skin_physiology0.66236730
103MP0000537_abnormal_urethra_morphology0.64992068
104MP0000230_abnormal_systemic_arterial0.64949853
105MP0006138_congestive_heart_failure0.64424227
106MP0008874_decreased_physiological_sensi0.63660675
107MP0010234_abnormal_vibrissa_follicle0.63492209
108MP0009672_abnormal_birth_weight0.60505073
109MP0009278_abnormal_bone_marrow0.58675964
110MP0002106_abnormal_muscle_physiology0.57838718
111MP0003303_peritoneal_inflammation0.56298395
112MP0005448_abnormal_energy_balance0.55757620
113MP0005165_increased_susceptibility_to0.55091795
114MP0008775_abnormal_heart_ventricle0.54622376
115MP0002796_impaired_skin_barrier0.53597717
116MP0001968_abnormal_touch/_nociception0.53392895
117MP0001661_extended_life_span0.53392445
118MP0003953_abnormal_hormone_level0.52612051
119MP0005187_abnormal_penis_morphology0.52422916
120MP0010368_abnormal_lymphatic_system0.52316209
121MP0003705_abnormal_hypodermis_morpholog0.52091741
122MP0002734_abnormal_mechanical_nocicepti0.52064195
123MP0004145_abnormal_muscle_electrophysio0.51947330
124MP0002089_abnormal_postnatal_growth/wei0.49470650
125MP0004085_abnormal_heartbeat0.49430267
126MP0009764_decreased_sensitivity_to0.48320343
127MP0002876_abnormal_thyroid_physiology0.47964408
128MP0009379_abnormal_foot_pigmentation0.47511557
129MP0004185_abnormal_adipocyte_glucose0.47415175
130MP0000681_abnormal_thyroid_gland0.47396804
131MP0000358_abnormal_cell_content/0.46723224
132MP0000467_abnormal_esophagus_morphology0.46463728
133MP0000759_abnormal_skeletal_muscle0.46380805
134MP0001853_heart_inflammation0.44857923
135MP0002877_abnormal_melanocyte_morpholog0.44273430
136MP0002136_abnormal_kidney_physiology0.44235368
137MP0008873_increased_physiological_sensi0.43275770
138MP0000538_abnormal_urinary_bladder0.42910058
139MP0003453_abnormal_keratinocyte_physiol0.42388820
140MP0001849_ear_inflammation0.41862819
141MP0009765_abnormal_xenobiotic_induced0.41431079
142MP0001765_abnormal_ion_homeostasis0.41377146
143MP0001727_abnormal_embryo_implantation0.39981749
144MP0005452_abnormal_adipose_tissue0.39816098

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.94354061
2Nemaline bodies (HP:0003798)7.78349701
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.71404446
4Type 1 muscle fiber predominance (HP:0003803)6.02225429
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.89224378
6Myopathic facies (HP:0002058)5.56491912
7Intrahepatic cholestasis (HP:0001406)5.08334789
8Hyperglycinuria (HP:0003108)4.74760833
9Deep venous thrombosis (HP:0002625)4.68541731
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.65700468
11Xanthomatosis (HP:0000991)4.64962849
12Hyperammonemia (HP:0001987)4.55484604
13Ketosis (HP:0001946)4.52862686
14Hypobetalipoproteinemia (HP:0003563)4.51364680
15Distal lower limb muscle weakness (HP:0009053)4.46147779
16Centrally nucleated skeletal muscle fibers (HP:0003687)4.42427014
17Abnormality of glycine metabolism (HP:0010895)4.38245456
18Abnormality of serine family amino acid metabolism (HP:0010894)4.38245456
19Prolonged partial thromboplastin time (HP:0003645)4.35019219
20Hyperglycinemia (HP:0002154)4.34588737
21EMG: myopathic abnormalities (HP:0003458)4.28297178
22Muscle hypertrophy of the lower extremities (HP:0008968)4.17746563
23Hyperlipoproteinemia (HP:0010980)4.13894613
24Hypoglycemic coma (HP:0001325)4.07572126
25Distal arthrogryposis (HP:0005684)3.99659335
26Cerebral edema (HP:0002181)3.91445515
27Round ear (HP:0100830)3.86500002
28Ketoacidosis (HP:0001993)3.85299512
29Abnormality of fatty-acid metabolism (HP:0004359)3.81612573
30Calf muscle hypertrophy (HP:0008981)3.73084288
31Muscle fiber splitting (HP:0003555)3.71718788
32Dicarboxylic aciduria (HP:0003215)3.71495023
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.71495023
34Epidermoid cyst (HP:0200040)3.66342779
35Abnormality of the calf musculature (HP:0001430)3.55712249
36Hypolipoproteinemia (HP:0010981)3.54460491
37Hyporeflexia of lower limbs (HP:0002600)3.52963208
38Ulnar deviation of the wrist (HP:0003049)3.52722233
39Progressive muscle weakness (HP:0003323)3.51869769
40Hepatic necrosis (HP:0002605)3.49889184
41Neck muscle weakness (HP:0000467)3.48317081
42Acute encephalopathy (HP:0006846)3.47211508
43Lethargy (HP:0001254)3.42321198
44Abnormality of skeletal muscle fiber size (HP:0012084)3.39883136
45Increased connective tissue (HP:0009025)3.35190611
46Complement deficiency (HP:0004431)3.32379799
47Muscle stiffness (HP:0003552)3.31488213
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30500330
49Abnormality of serum amino acid levels (HP:0003112)3.27711764
50Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24080630
51Hypoalphalipoproteinemia (HP:0003233)3.21981383
52Rimmed vacuoles (HP:0003805)3.20855410
53Gout (HP:0001997)3.20324275
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.19565894
55Abnormality of glutamine family amino acid metabolism (HP:0010902)3.15732657
56Joint hemorrhage (HP:0005261)3.15567125
57Metabolic acidosis (HP:0001942)3.13503073
58Distal lower limb amyotrophy (HP:0008944)3.13074355
59Asymmetric septal hypertrophy (HP:0001670)3.12894287
60Abnormality of sulfur amino acid metabolism (HP:0004339)3.11951829
61Abnormality of methionine metabolism (HP:0010901)3.08062703
62Myoglobinuria (HP:0002913)3.06924528
63Calcaneovalgus deformity (HP:0001848)3.04827771
64Fetal akinesia sequence (HP:0001989)2.99739466
65Hepatocellular necrosis (HP:0001404)2.97533519
66Bulbar palsy (HP:0001283)2.97452336
67Acute necrotizing encephalopathy (HP:0006965)2.96073332
68Abnormal mitochondria in muscle tissue (HP:0008316)2.95201214
69Increased variability in muscle fiber diameter (HP:0003557)2.86047019
70Abnormality of the common coagulation pathway (HP:0010990)2.84114076
71Increased muscle lipid content (HP:0009058)2.79195940
72Mildly elevated creatine phosphokinase (HP:0008180)2.77520789
73Rhabdomyolysis (HP:0003201)2.76008304
74Achilles tendon contracture (HP:0001771)2.71946639
75Abnormality of pyrimidine metabolism (HP:0004353)2.71499630
76Mitochondrial inheritance (HP:0001427)2.70306575
77Fat malabsorption (HP:0002630)2.69780487
78Lactic acidosis (HP:0003128)2.69388053
79Vomiting (HP:0002013)2.69123182
80Hyperbilirubinemia (HP:0002904)2.68008210
81Increased CSF lactate (HP:0002490)2.66693930
82Abnormality of the intrinsic pathway (HP:0010989)2.66351270
83Delayed CNS myelination (HP:0002188)2.66090475
84Abnormality of nucleobase metabolism (HP:0010932)2.65818512
85Generalized aminoaciduria (HP:0002909)2.64691655
86Abnormality of purine metabolism (HP:0004352)2.62977953
87Malignant hyperthermia (HP:0002047)2.60745247
88Late onset (HP:0003584)2.58720502
89Subaortic stenosis (HP:0001682)2.57946242
90Abnormality of the left ventricular outflow tract (HP:0011103)2.57946242
91Deformed tarsal bones (HP:0008119)2.56915878
92Bundle branch block (HP:0011710)2.56893161
93Abnormality of the Achilles tendon (HP:0005109)2.51533931
94Limb-girdle muscle atrophy (HP:0003797)2.51283245
95Increased intramyocellular lipid droplets (HP:0012240)2.51271974
96Palpitations (HP:0001962)2.50336732
97Exercise-induced myalgia (HP:0003738)2.48988215
98Myotonia (HP:0002486)2.46441075
99Absent phalangeal crease (HP:0006109)2.45085858
100Hypochromic microcytic anemia (HP:0004840)2.44290914
101Nausea (HP:0002018)2.41395090
102Proximal tubulopathy (HP:0000114)2.40441598
103Abnormal atrioventricular conduction (HP:0005150)2.36280826
104Hypercholesterolemia (HP:0003124)2.35796613
105Progressive macrocephaly (HP:0004481)2.35282828
106Ventricular tachycardia (HP:0004756)2.35090483
107Hepatocellular carcinoma (HP:0001402)2.32924209
108Difficulty running (HP:0009046)2.32729963
109Increased purine levels (HP:0004368)2.32054630
110Hyperuricemia (HP:0002149)2.32054630
111Abnormality of complement system (HP:0005339)2.31505349
112Areflexia of lower limbs (HP:0002522)2.31435649
113Conjugated hyperbilirubinemia (HP:0002908)2.29824042
114Ragged-red muscle fibers (HP:0003200)2.29102888
115Skin nodule (HP:0200036)2.29029324
116Heart block (HP:0012722)2.27796611
117Difficulty climbing stairs (HP:0003551)2.27532725
118Generalized muscle weakness (HP:0003324)2.26841838
119EMG: neuropathic changes (HP:0003445)2.25938984
120Frequent falls (HP:0002359)2.25591592
121Glycosuria (HP:0003076)2.24692557
122Abnormality of urine glucose concentration (HP:0011016)2.24692557
123Cholecystitis (HP:0001082)2.23347514
124Abnormal gallbladder physiology (HP:0012438)2.23347514
125Foot dorsiflexor weakness (HP:0009027)2.22719682
126Abnormality of the foot musculature (HP:0001436)2.21117518
127Abnormality of glycolysis (HP:0004366)2.18621723
128Increased serum pyruvate (HP:0003542)2.18621723
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17928505
130Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17928505
131Lipid accumulation in hepatocytes (HP:0006561)2.15841043
132Neonatal onset (HP:0003623)2.15487673
133Increased serum lactate (HP:0002151)2.14469563
134Cholelithiasis (HP:0001081)2.11189350
135Abnormality of the neuromuscular junction (HP:0003398)2.10732954
136Fatigable weakness (HP:0003473)2.10732954
137Gowers sign (HP:0003391)2.10252695
138Scapular winging (HP:0003691)2.09950365
139Methylmalonic aciduria (HP:0012120)2.09730094
140Hypoglycemic seizures (HP:0002173)2.09667646
141CNS demyelination (HP:0007305)2.08879410
142Back pain (HP:0003418)2.06770792
143Lower limb amyotrophy (HP:0007210)2.06578217
144Brushfield spots (HP:0001088)2.05946074
145Sudden death (HP:0001699)2.05319225
146Dilated cardiomyopathy (HP:0001644)2.05128774
147Abnormal gallbladder morphology (HP:0012437)2.04688391
148Atrioventricular block (HP:0001678)2.02748474
149Stridor (HP:0010307)2.02699367
150Respiratory failure (HP:0002878)2.00941131
151Weak cry (HP:0001612)1.99025709
152Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97620185
153Slender build (HP:0001533)1.97560015
154Spinal rigidity (HP:0003306)1.96271027
155Irritability (HP:0000737)1.96266055
156Malnutrition (HP:0004395)1.95153447
157Easy fatigability (HP:0003388)1.95014013
158Pancreatitis (HP:0001733)1.94683670
159Hyperinsulinemic hypoglycemia (HP:0000825)1.92823890
160Lipoatrophy (HP:0100578)1.90270994
161Steatorrhea (HP:0002570)1.90091191
162Muscle fiber atrophy (HP:0100295)1.89821513
163Exercise intolerance (HP:0003546)1.89650394
164Exercise-induced muscle cramps (HP:0003710)1.88931902
165Popliteal pterygium (HP:0009756)1.88639464
166Abnormality of the calcaneus (HP:0008364)1.87055167
167Generalized amyotrophy (HP:0003700)1.86680050
168Ulnar bowing (HP:0003031)1.86000416
169Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84495854
170Abnormal finger flexion creases (HP:0006143)1.84423790
171Respiratory insufficiency due to muscle weakness (HP:0002747)1.83286867
172Waddling gait (HP:0002515)1.82042886
173Amniotic constriction ring (HP:0009775)1.81803019
174Abnormality of placental membranes (HP:0011409)1.81803019
175Testicular atrophy (HP:0000029)1.76751622
176Reticulocytosis (HP:0001923)1.75473006
177Diaphragmatic weakness (HP:0009113)1.74717916
178Aplasia of the musculature (HP:0100854)1.74051940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.52104226
2NME23.70223403
3TLK13.63593683
4ICK3.54248009
5ERN12.72790457
6PINK12.70084639
7SMG12.43493149
8TRIB32.25063557
9MAP3K102.18008510
10EEF2K2.14627934
11TTN2.03859185
12PDK42.03342613
13PDK32.03342613
14PKN22.03074241
15STK162.02527145
16MYLK1.95496231
17MAP3K111.92855871
18FGFR41.92425813
19GRK61.91502292
20KDR1.90458755
21SIK11.73519341
22IRAK31.64496928
23BUB11.61664425
24MUSK1.56741645
25PHKG11.54139751
26PHKG21.54139751
27PIM21.51153506
28TESK11.48453101
29PRPF4B1.45563752
30OBSCN1.37939650
31MAP2K31.22112271
32NEK11.21683537
33MAPK111.21148926
34MAP2K61.19579164
35EPHA21.18896849
36WEE11.15353194
37MAP2K21.14599869
38MAP2K41.14372146
39LATS11.13991077
40TESK21.12157593
41FLT31.11624452
42PIK3CG1.10224959
43CSNK1G31.09610040
44LMTK21.06228305
45ABL21.05520325
46TAOK31.05485574
47PRKD31.03684006
48MAPK121.01742487
49BRAF1.01238912
50TAOK21.00958418
51TYK21.00459801
52VRK20.95447959
53GRK70.95302602
54CSNK1G10.94535280
55TAOK10.94035830
56LIMK10.91944423
57MAP3K90.91341356
58DAPK30.90570078
59NME10.84237504
60PDK20.81920795
61PBK0.81424130
62ERBB40.79405346
63NEK90.78621639
64PRKD20.77905144
65MAP3K10.77463644
66MAPK40.75089168
67MAPKAPK30.73716586
68WNK40.73174700
69CAMK2G0.71303639
70CSNK1A1L0.70882392
71PTK60.70878578
72INSRR0.69334431
73TIE10.68408150
74ARAF0.66674027
75MAP4K10.66387892
76CCNB10.66243888
77LRRK20.65531642
78ILK0.64862032
79CSNK1G20.62333648
80MOS0.61002451
81RIPK10.59520250
82MAP3K120.58728316
83KSR20.58016937
84DAPK20.58012736
85CDK40.57736072
86DYRK1B0.57542026
87AURKA0.55980662
88MARK10.54474282
89CAMK2B0.53905792
90IRAK20.53814518
91MTOR0.53201862
92MAP3K130.52408025
93IRAK10.50825681
94PRKACG0.50749328
95MST1R0.50610697
96MAPK150.50246443
97MAP3K30.46332080
98PRKAA20.45861104
99PRKAA10.45567046
100RPS6KA20.44562364
101CDK70.43992772
102PAK10.43897575
103ZAP700.43439330
104LATS20.41916381
105JAK20.41578895
106AKT20.40573155
107CDK80.39775597
108PDPK10.39612845
109CAMK2D0.38389871
110MAP3K50.37748453
111CDK190.35812937
112RAF10.34192503
113PRKACA0.33878478
114CDK11A0.33431925
115PRKCI0.32704767
116RPS6KA50.32602244
117SIK20.32309922
118STK40.29828182
119PAK40.29783862
120TBK10.28495383
121CDK150.28381384
122PRKD10.28310169
123DYRK30.28090699
124DMPK0.27566416
125RPS6KA10.26941614
126BTK0.25418735
127RPS6KB20.24746842
128RPS6KC10.24527908
129RPS6KL10.24527908
130MAPK70.24405240
131PDK10.24279820
132MAP3K60.23551242
133EIF2AK30.23375461
134MAP3K80.22623652
135DAPK10.22125967
136MAP3K70.21637269
137PRKG20.20783023
138SCYL20.20587245
139MAP2K10.20102178
140RPS6KA60.19964002

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.73361043
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29286639
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.11937093
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.79854575
5Fatty acid degradation_Homo sapiens_hsa000712.79396959
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.72066323
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.71172458
8Arginine biosynthesis_Homo sapiens_hsa002202.69123591
9Propanoate metabolism_Homo sapiens_hsa006402.64940995
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52217669
11Tryptophan metabolism_Homo sapiens_hsa003802.47689598
12Nitrogen metabolism_Homo sapiens_hsa009102.37761877
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.22078605
14Butanoate metabolism_Homo sapiens_hsa006502.20465474
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01827184
16Peroxisome_Homo sapiens_hsa041462.00036154
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97774877
18Fatty acid metabolism_Homo sapiens_hsa012121.91366921
19Complement and coagulation cascades_Homo sapiens_hsa046101.89655986
20Carbon metabolism_Homo sapiens_hsa012001.89199367
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84974702
22beta-Alanine metabolism_Homo sapiens_hsa004101.84438463
23Pyruvate metabolism_Homo sapiens_hsa006201.81961765
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74973736
25PPAR signaling pathway_Homo sapiens_hsa033201.72116941
26Folate biosynthesis_Homo sapiens_hsa007901.71108555
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.68802480
28Dilated cardiomyopathy_Homo sapiens_hsa054141.68601461
29Biosynthesis of amino acids_Homo sapiens_hsa012301.67519164
30Oxidative phosphorylation_Homo sapiens_hsa001901.60420216
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56972803
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56578249
33Histidine metabolism_Homo sapiens_hsa003401.54993606
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53794997
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.52942531
36Parkinsons disease_Homo sapiens_hsa050121.45780834
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43555832
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43534502
39Chemical carcinogenesis_Homo sapiens_hsa052041.43377426
40Phenylalanine metabolism_Homo sapiens_hsa003601.40745771
41Selenocompound metabolism_Homo sapiens_hsa004501.39597459
42Fatty acid elongation_Homo sapiens_hsa000621.37727391
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.36662301
44Sulfur metabolism_Homo sapiens_hsa009201.36617133
45Arginine and proline metabolism_Homo sapiens_hsa003301.33371277
46Fat digestion and absorption_Homo sapiens_hsa049751.24256340
47Starch and sucrose metabolism_Homo sapiens_hsa005001.22883878
48Vitamin B6 metabolism_Homo sapiens_hsa007501.22805505
49Sulfur relay system_Homo sapiens_hsa041221.21662137
50Tyrosine metabolism_Homo sapiens_hsa003501.18590593
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.14509113
52Bile secretion_Homo sapiens_hsa049761.13290534
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13276019
54Caffeine metabolism_Homo sapiens_hsa002321.07917739
55Retinol metabolism_Homo sapiens_hsa008301.07579679
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05929614
57Alzheimers disease_Homo sapiens_hsa050100.98442255
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98125979
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95471715
60Staphylococcus aureus infection_Homo sapiens_hsa051500.93978691
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93634627
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.90786476
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.90689061
64Huntingtons disease_Homo sapiens_hsa050160.87690775
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86832461
66Glutathione metabolism_Homo sapiens_hsa004800.85899931
67Pentose phosphate pathway_Homo sapiens_hsa000300.83477881
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83387775
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78097386
70Metabolic pathways_Homo sapiens_hsa011000.75858072
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75243712
72One carbon pool by folate_Homo sapiens_hsa006700.72690544
73Cardiac muscle contraction_Homo sapiens_hsa042600.72004169
74Vitamin digestion and absorption_Homo sapiens_hsa049770.69354538
75Glycerolipid metabolism_Homo sapiens_hsa005610.68725829
76Synaptic vesicle cycle_Homo sapiens_hsa047210.67139577
77ABC transporters_Homo sapiens_hsa020100.64660296
78Fructose and mannose metabolism_Homo sapiens_hsa000510.64475654
79Vibrio cholerae infection_Homo sapiens_hsa051100.62642087
80Bladder cancer_Homo sapiens_hsa052190.62586708
81Alcoholism_Homo sapiens_hsa050340.62334812
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59786789
83Galactose metabolism_Homo sapiens_hsa000520.58952507
84Ribosome_Homo sapiens_hsa030100.58413364
85Other glycan degradation_Homo sapiens_hsa005110.55841229
86Lysine degradation_Homo sapiens_hsa003100.55372677
87Circadian rhythm_Homo sapiens_hsa047100.52419553
88Calcium signaling pathway_Homo sapiens_hsa040200.51703148
89Oxytocin signaling pathway_Homo sapiens_hsa049210.43319659
90VEGF signaling pathway_Homo sapiens_hsa043700.43164976
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40856973
92Pyrimidine metabolism_Homo sapiens_hsa002400.40850494
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37952078
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34987655
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33493926
96Acute myeloid leukemia_Homo sapiens_hsa052210.28819842
97Fatty acid biosynthesis_Homo sapiens_hsa000610.28724247
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27262785
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.26755785
100mTOR signaling pathway_Homo sapiens_hsa041500.26419838
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.24528770
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24176479
103Steroid biosynthesis_Homo sapiens_hsa001000.23020204
104Tight junction_Homo sapiens_hsa045300.21276453
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21085689
106Nucleotide excision repair_Homo sapiens_hsa034200.20498141
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.20472086
108Linoleic acid metabolism_Homo sapiens_hsa005910.19426104
109Long-term potentiation_Homo sapiens_hsa047200.18887140
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18559293
111Proteasome_Homo sapiens_hsa030500.18530836
112Prion diseases_Homo sapiens_hsa050200.16907564
113Glucagon signaling pathway_Homo sapiens_hsa049220.16111272
114GnRH signaling pathway_Homo sapiens_hsa049120.15231204
115Insulin resistance_Homo sapiens_hsa049310.14939671
116N-Glycan biosynthesis_Homo sapiens_hsa005100.13646080
117DNA replication_Homo sapiens_hsa030300.12637305
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.07718855
119Insulin signaling pathway_Homo sapiens_hsa049100.06808886
120Purine metabolism_Homo sapiens_hsa002300.05449121
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05034109
122AMPK signaling pathway_Homo sapiens_hsa041520.04888063
123Arachidonic acid metabolism_Homo sapiens_hsa005900.02414645
124RNA polymerase_Homo sapiens_hsa03020-0.0603360
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.0588156
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0457449
127Regulation of autophagy_Homo sapiens_hsa04140-0.0444339
128Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0180809
129Base excision repair_Homo sapiens_hsa03410-0.0002737

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