ENDOU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hair cycle (GO:0042633)9.86331661
2molting cycle (GO:0042303)9.86331661
3negative regulation of thymocyte apoptotic process (GO:0070244)9.35258654
4keratinization (GO:0031424)8.90053876
5regulation of gamma-delta T cell differentiation (GO:0045586)8.15562748
6estrogen biosynthetic process (GO:0006703)7.91140195
7positive T cell selection (GO:0043368)7.51984147
8positive regulation of gamma-delta T cell activation (GO:0046645)7.38917108
9regulation of gamma-delta T cell activation (GO:0046643)7.38705339
10keratinocyte proliferation (GO:0043616)7.19207633
11desmosome organization (GO:0002934)7.05571392
12T cell selection (GO:0045058)6.36699746
13establishment of skin barrier (GO:0061436)6.28864042
14gap junction assembly (GO:0016264)6.23560766
15negative T cell selection (GO:0043383)5.90396404
16hair follicle morphogenesis (GO:0031069)5.76468061
17regulation of water loss via skin (GO:0033561)5.70778613
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.53334825
19somatic diversification of immune receptors via germline recombination within a single locus (GO:0005.49369882
20somatic cell DNA recombination (GO:0016444)5.49369882
21Peyers patch development (GO:0048541)5.42211915
22mucosal-associated lymphoid tissue development (GO:0048537)5.42211915
23regulation of thymocyte apoptotic process (GO:0070243)5.17728252
24positive regulation of chemokine secretion (GO:0090197)5.14928807
25activated T cell proliferation (GO:0050798)5.12446651
26somatic diversification of immune receptors (GO:0002200)5.12359486
27cellular hyperosmotic response (GO:0071474)5.09817346
28negative regulation of T cell apoptotic process (GO:0070233)5.02702748
29T cell receptor signaling pathway (GO:0050852)5.00595448
30polarized epithelial cell differentiation (GO:0030859)4.93877937
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.83333858
32skeletal muscle tissue regeneration (GO:0043403)4.67325996
33T cell differentiation in thymus (GO:0033077)4.67218511
34lipoxygenase pathway (GO:0019372)4.65319459
35hemidesmosome assembly (GO:0031581)4.61683920
36keratinocyte differentiation (GO:0030216)4.54435083
37T cell differentiation (GO:0030217)4.49135290
38positive thymic T cell selection (GO:0045059)4.47119460
39regulation of chemokine secretion (GO:0090196)4.45120449
40alpha-beta T cell differentiation (GO:0046632)4.45070492
41intermediate filament organization (GO:0045109)4.35888020
42antigen receptor-mediated signaling pathway (GO:0050851)4.32402588
43peptide cross-linking (GO:0018149)4.31701926
44endothelium development (GO:0003158)4.31598382
45genitalia morphogenesis (GO:0035112)4.28939358
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26404641
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26404641
48eyelid development in camera-type eye (GO:0061029)4.23049591
49intermediate filament-based process (GO:0045103)4.19850139
50alpha-beta T cell activation (GO:0046631)4.16735359
51thymic T cell selection (GO:0045061)4.15687416
52response to phenylpropanoid (GO:0080184)4.09331239
53cellular response to interleukin-4 (GO:0071353)4.04606045
54positive regulation of interleukin-2 production (GO:0032743)4.02198636
55regulation of keratinocyte differentiation (GO:0045616)3.94157602
56antigen processing and presentation of endogenous antigen (GO:0019883)3.89160721
57T cell costimulation (GO:0031295)3.87345967
58fatty acid elongation (GO:0030497)3.86925939
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.84976392
60lymphocyte costimulation (GO:0031294)3.77687536
61epidermal cell differentiation (GO:0009913)3.77289885
62regulation of glomerular filtration (GO:0003093)3.76112676
63negative regulation of lymphocyte apoptotic process (GO:0070229)3.74670858
64molting cycle process (GO:0022404)3.73680217
65hair cycle process (GO:0022405)3.73680217
66* female pregnancy (GO:0007565)3.72911784
67T cell homeostasis (GO:0043029)3.72275964
68response to interleukin-4 (GO:0070670)3.68891041
69epidermis development (GO:0008544)3.67425317
70regulation of T cell receptor signaling pathway (GO:0050856)3.66746863
71transepithelial transport (GO:0070633)3.64703349
72negative thymic T cell selection (GO:0045060)3.61705383
73epithelial cell maturation (GO:0002070)3.58850402
74intestinal epithelial cell development (GO:0060576)3.57467172
75multicellular organismal water homeostasis (GO:0050891)3.57251369
76negative regulation of erythrocyte differentiation (GO:0045647)3.56228810
77estrogen metabolic process (GO:0008210)3.53847640
78establishment of planar polarity (GO:0001736)3.53593869
79establishment of tissue polarity (GO:0007164)3.53593869
80glucocorticoid biosynthetic process (GO:0006704)3.49034317
81response to follicle-stimulating hormone (GO:0032354)3.47969245
82mast cell activation (GO:0045576)3.46475653
83lateral sprouting from an epithelium (GO:0060601)3.44221997
84positive regulation of calcium-mediated signaling (GO:0050850)3.41816305
85prostate gland growth (GO:0060736)3.41795904
86long-chain fatty acid biosynthetic process (GO:0042759)3.40121914
87regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.38893391
88phosphatidylinositol acyl-chain remodeling (GO:0036149)3.35583807
89linoleic acid metabolic process (GO:0043651)3.35348611
90DNA unwinding involved in DNA replication (GO:0006268)3.35110912
91regulation of gonadotropin secretion (GO:0032276)3.33731018
92androgen biosynthetic process (GO:0006702)3.29443906
93skin morphogenesis (GO:0043589)3.27436231
94negative regulation of cardiac muscle tissue growth (GO:0055022)3.27175326
95negative regulation of heart growth (GO:0061117)3.27175326
96ectoderm development (GO:0007398)3.25960038
97establishment of integrated proviral latency (GO:0075713)3.25831903
98adenine nucleotide transport (GO:0051503)3.25023820
99regulation of interleukin-2 production (GO:0032663)3.24587557
100DNA ligation (GO:0006266)3.19681723
101positive regulation of histone deacetylation (GO:0031065)3.17882968
102viral transcription (GO:0019083)3.17504433
103phosphatidylserine acyl-chain remodeling (GO:0036150)3.16128262
104purine ribonucleotide transport (GO:0015868)3.15736812
105T cell activation (GO:0042110)3.15257929
106lymphocyte homeostasis (GO:0002260)3.13529614
107immune response-activating cell surface receptor signaling pathway (GO:0002429)3.13491301
108mast cell activation involved in immune response (GO:0002279)3.11362189
109mast cell degranulation (GO:0043303)3.11362189
110* multi-multicellular organism process (GO:0044706)3.11244131
111atrial cardiac muscle cell action potential (GO:0086014)3.10862631
112modulation by virus of host process (GO:0019054)3.09443559
113chronic inflammatory response (GO:0002544)3.09352951
114regulation of interleukin-2 biosynthetic process (GO:0045076)3.08928909
115epithelial cell differentiation involved in prostate gland development (GO:0060742)3.06911707
116regulation of tight junction assembly (GO:2000810)3.06160978
117keratinocyte development (GO:0003334)3.04210358
118ribosomal small subunit assembly (GO:0000028)3.04115955
119renal system process involved in regulation of blood volume (GO:0001977)3.03709348
120lymphocyte differentiation (GO:0030098)3.01744247
121translational termination (GO:0006415)2.98989732
122positive regulation of B cell differentiation (GO:0045579)2.97819945
123thymus development (GO:0048538)2.97232874
124interferon-gamma production (GO:0032609)2.96862829
125CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.95273330
126positive regulation of granulocyte differentiation (GO:0030854)2.94092619
127regulation of chromatin silencing (GO:0031935)2.92523217
128apical protein localization (GO:0045176)2.91735971
129B cell receptor signaling pathway (GO:0050853)2.90563999
130regulation of T cell apoptotic process (GO:0070232)2.90541337
131positive regulation of keratinocyte differentiation (GO:0045618)2.90071446
132negative regulation of leukocyte apoptotic process (GO:2000107)2.87552576
133epithelium development (GO:0060429)2.86666275
134regulation of regulatory T cell differentiation (GO:0045589)2.85980618
135detection of bacterium (GO:0016045)2.85685866
136regulation of T cell differentiation (GO:0045580)2.84323221
137positive regulation of gene expression, epigenetic (GO:0045815)2.83611856
138pyrimidine-containing compound transmembrane transport (GO:0072531)2.82851908
139regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82830684
140regulation of phospholipase A2 activity (GO:0032429)2.82060341
141negative regulation of T cell receptor signaling pathway (GO:0050860)2.81867917
142androgen metabolic process (GO:0008209)2.80627929
143regulation of ruffle assembly (GO:1900027)2.80142793
144water homeostasis (GO:0030104)2.75042421
145* multi-organism reproductive process (GO:0044703)2.74155724
146regulation of keratinocyte proliferation (GO:0010837)2.72998129
147positive regulation of histone H3-K4 methylation (GO:0051571)2.71813350
148cellular response to osmotic stress (GO:0071470)2.71063188
149regulation of histone H3-K9 methylation (GO:0051570)2.71047196
150intermediate filament cytoskeleton organization (GO:0045104)2.70792013
151regulation of cholesterol homeostasis (GO:2000188)2.70630767
152positive regulation of growth hormone secretion (GO:0060124)2.70606643
153positive regulation of epidermal cell differentiation (GO:0045606)2.70102885
154leukocyte homeostasis (GO:0001776)2.70101548
155production of molecular mediator involved in inflammatory response (GO:0002532)2.68539472
156regulation of defense response to virus by virus (GO:0050690)2.67844102
157natural killer cell differentiation (GO:0001779)2.67355992
158detection of other organism (GO:0098543)2.66023455
159phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64023251
160regulation of epidermis development (GO:0045682)2.62810231
161regulation of T cell tolerance induction (GO:0002664)2.62261281
162CD4-positive, alpha-beta T cell activation (GO:0035710)2.62138104
163glucosamine-containing compound catabolic process (GO:1901072)2.62023095
164bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62012692
165regulation of germinal center formation (GO:0002634)2.60393154
166regulation of axon regeneration (GO:0048679)2.59614251
167regulation of neuron projection regeneration (GO:0070570)2.59614251
168positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.57211010
169negative regulation of keratinocyte proliferation (GO:0010839)2.56261359
170cellular response to arsenic-containing substance (GO:0071243)2.52973860
171polyol transport (GO:0015791)2.52501253
172G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.52037856
173magnesium ion transport (GO:0015693)2.51173282
174sphingoid metabolic process (GO:0046519)2.50477069
175one-carbon compound transport (GO:0019755)2.50413152
176positive regulation of epidermis development (GO:0045684)2.48547219
177regulation of natural killer cell differentiation (GO:0032823)2.47451008
178imidazole-containing compound metabolic process (GO:0052803)2.47216461
179regulation of epidermal cell differentiation (GO:0045604)2.46211503
180cell-cell junction assembly (GO:0007043)2.44739641
181regulation of protein polyubiquitination (GO:1902914)2.44452623
182purine nucleotide transport (GO:0015865)2.41766936
183V(D)J recombination (GO:0033151)11.6224815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.92703845
2E2F7_22180533_ChIP-Seq_HELA_Human6.94038257
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.74419854
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.55912253
5MYC_22102868_ChIP-Seq_BL_Human4.02668824
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82386624
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.75379412
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.50539353
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.95859353
10RUNX_20019798_ChIP-Seq_JUKART_Human2.86118541
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.69095885
12MYB_26560356_Chip-Seq_TH2_Human2.68872969
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60253767
14UTX_26944678_Chip-Seq_JUKART_Human2.60043302
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.47988969
16VDR_21846776_ChIP-Seq_THP-1_Human2.42625454
17TCF7_22412390_ChIP-Seq_EML_Mouse2.41852245
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.31689389
19ZNF217_24962896_ChIP-Seq_MCF-7_Human2.28300961
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21975440
21MAF_26560356_Chip-Seq_TH1_Human2.21778900
22AHR_22903824_ChIP-Seq_MCF-7_Human2.10239286
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03893549
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97261423
25TP63_23658742_ChIP-Seq_EP156T_Human1.96707449
26* KDM2B_26808549_Chip-Seq_DND41_Human1.92450219
27GATA3_27048872_Chip-Seq_THYMUS_Human1.86456992
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83201513
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82710852
30SCL_19346495_ChIP-Seq_HPC-7_Human1.81967457
31P63_26484246_Chip-Seq_KERATINOCYTES_Human1.76297457
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72182592
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71908912
34MYB_26560356_Chip-Seq_TH1_Human1.70964263
35VDR_24763502_ChIP-Seq_THP-1_Human1.66025027
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.66003167
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.65306542
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60154302
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.59673595
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.58031363
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52107132
42GATA3_24758297_ChIP-Seq_MCF-7_Human1.51666966
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46853503
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46736598
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44757602
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.41311044
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40237155
48SOX2_20726797_ChIP-Seq_SW620_Human1.36752780
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35887109
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35798730
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33547241
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30915699
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29832358
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.29548240
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28216369
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27663892
57AR_21572438_ChIP-Seq_LNCaP_Human1.27437923
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26773486
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.25656269
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24175959
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.22731428
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22473901
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22473901
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22375606
65MAF_26560356_Chip-Seq_TH2_Human1.21903735
66CJUN_26792858_Chip-Seq_BT549_Human1.20426184
67* RACK7_27058665_Chip-Seq_MCF-7_Human1.19392901
68CIITA_25753668_ChIP-Seq_RAJI_Human1.18792836
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17417192
70TP53_18474530_ChIP-ChIP_U2OS_Human1.17200775
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.16571061
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16305389
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15658750
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15265855
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.13796142
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12978906
77LXR_22292898_ChIP-Seq_THP-1_Human1.12371945
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12281387
79JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11260064
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10180971
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10087248
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09648716
83PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09645113
84ERG_20517297_ChIP-Seq_VCAP_Human1.07660376
85VDR_22108803_ChIP-Seq_LS180_Human1.06929081
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05262422
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05262422
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04742180
89KLF5_25053715_ChIP-Seq_YYC3_Human1.04554965
90ATF3_27146783_Chip-Seq_COLON_Human1.03974223
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02167766
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01764529
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.00882705
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00714215
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00121965
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99842312
97CDX2_22108803_ChIP-Seq_LS180_Human0.99636413
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98340393
99BP1_19119308_ChIP-ChIP_Hs578T_Human0.97065387
100* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95799091
101GATA4_25053715_ChIP-Seq_YYC3_Human0.95572458
102BCOR_27268052_Chip-Seq_Bcells_Human0.94150941
103SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94016257
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93241439
105VDR_24787735_ChIP-Seq_THP-1_Human0.92878256
106ZNF263_19887448_ChIP-Seq_K562_Human0.92593276
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89355373
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.88631764
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88443854
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86601391
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86453860
112CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85994520
113TP63_22573176_ChIP-Seq_HFKS_Human0.85870606
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85723458
115GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85699170
116NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85675397
117CLOCK_20551151_ChIP-Seq_293T_Human0.85480856
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84786239
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84390642
120P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84055324
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83819381
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83678847
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82116730
124EGR1_19032775_ChIP-ChIP_M12_Human0.80820260
125SPI1_23127762_ChIP-Seq_K562_Human0.80737598
126NCOR1_26117541_ChIP-Seq_K562_Human0.80678836
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80621079
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.80616612
129SA1_27219007_Chip-Seq_ERYTHROID_Human0.80544920
130TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80544459
131SPI1_23547873_ChIP-Seq_NB4_Human0.80417700
132HTT_18923047_ChIP-ChIP_STHdh_Human0.80390391
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.80194619
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80162846
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80109892
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.78645574
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.77713576
138BRD4_25478319_ChIP-Seq_HGPS_Human0.77048502
139P68_20966046_ChIP-Seq_HELA_Human0.76451834
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76310131
141HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76154721
142AR_25329375_ChIP-Seq_VCAP_Human0.76017135
143GATA3_21878914_ChIP-Seq_MCF-7_Human0.76014656
144* TAF2_19829295_ChIP-Seq_ESCs_Human0.75754312
145CHD1_26751641_Chip-Seq_LNCaP_Human0.75733160
146E2F1_20622854_ChIP-Seq_HELA_Human0.75508201
147TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75286736
148* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74768633
149OCT1_27270436_Chip-Seq_PROSTATE_Human0.73807123
150ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73663623
151FOXH1_21741376_ChIP-Seq_EPCs_Human0.73408550
152* CEBPB_22108803_ChIP-Seq_LS180_Human0.72917632
153IGF1R_20145208_ChIP-Seq_DFB_Human0.72709830
154RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72315853
155P53_22127205_ChIP-Seq_FIBROBLAST_Human0.71952832
156FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71717962
157RXR_22108803_ChIP-Seq_LS180_Human0.71354350
158ELF1_20517297_ChIP-Seq_JURKAT_Human0.71222479
159P300_27058665_Chip-Seq_ZR-75-30cells_Human0.71169047
160TCF4_22108803_ChIP-Seq_LS180_Human0.70991987
161FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70944367
162PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70905138
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70296464
164GATA2_19941826_ChIP-Seq_K562_Human0.70226277
165GATA6_25053715_ChIP-Seq_YYC3_Human0.69823533
166HOXB7_26014856_ChIP-Seq_BT474_Human0.69053137
167PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68802539
168BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68575181
169TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68365848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.29432674
2MP0005409_darkened_coat_color4.10101101
3MP0000579_abnormal_nail_morphology3.85352908
4MP0003763_abnormal_thymus_physiology3.66504570
5MP0004381_abnormal_hair_follicle3.63378304
6MP0004947_skin_inflammation3.61283707
7MP0005501_abnormal_skin_physiology3.43951715
8MP0009379_abnormal_foot_pigmentation3.34445291
9MP0002166_altered_tumor_susceptibility3.31127756
10MP0000383_abnormal_hair_follicle3.27686693
11MP0005275_abnormal_skin_tensile3.23369034
12MP0010234_abnormal_vibrissa_follicle3.19861849
13MP0009697_abnormal_copulation3.06562378
14MP0010678_abnormal_skin_adnexa2.85464105
15MP0004043_abnormal_pH_regulation2.70776786
16MP0002006_tumorigenesis2.62454564
17MP0000703_abnormal_thymus_morphology2.61473549
18MP0001216_abnormal_epidermal_layer2.59931285
19MP0002098_abnormal_vibrissa_morphology2.53641171
20MP0001849_ear_inflammation2.33131150
21MP0005671_abnormal_response_to2.26386362
22MP0002060_abnormal_skin_morphology2.22062045
23MP0000377_abnormal_hair_follicle2.18658626
24MP0010771_integument_phenotype2.16506408
25MP0000647_abnormal_sebaceous_gland2.07986669
26MP0003705_abnormal_hypodermis_morpholog2.05031892
27MP0000685_abnormal_immune_system2.04733438
28MP0002132_abnormal_respiratory_system2.00297877
29MP0003453_abnormal_keratinocyte_physiol1.97735483
30MP0002095_abnormal_skin_pigmentation1.96514157
31MP0009278_abnormal_bone_marrow1.86675113
32MP0004782_abnormal_surfactant_physiolog1.84358286
33MP0000467_abnormal_esophagus_morphology1.83098803
34MP0001243_abnormal_dermal_layer1.75416933
35MP0010094_abnormal_chromosome_stability1.73514000
36MP0001879_abnormal_lymphatic_vessel1.71384304
37MP0001188_hyperpigmentation1.70790981
38MP0002398_abnormal_bone_marrow1.67819526
39MP0001835_abnormal_antigen_presentation1.63013673
40MP0001800_abnormal_humoral_immune1.61887970
41MP0010155_abnormal_intestine_physiology1.61233635
42MP0002722_abnormal_immune_system1.59118051
43MP0005377_hearing/vestibular/ear_phenot1.58868933
44MP0003878_abnormal_ear_physiology1.58868933
45MP0009931_abnormal_skin_appearance1.57707882
46MP0001191_abnormal_skin_condition1.53372448
47MP0000367_abnormal_coat/_hair1.52587981
48MP0000427_abnormal_hair_cycle1.50527028
49MP0004264_abnormal_extraembryonic_tissu1.48113461
50MP0001790_abnormal_immune_system1.46058623
51MP0005387_immune_system_phenotype1.46058623
52MP0004885_abnormal_endolymph1.38337634
53MP0000716_abnormal_immune_system1.34195230
54MP0009333_abnormal_splenocyte_physiolog1.33486555
55MP0010352_gastrointestinal_tract_polyps1.33422854
56MP0004808_abnormal_hematopoietic_stem1.33028321
57MP0005451_abnormal_body_composition1.27496976
58MP0009785_altered_susceptibility_to1.26780755
59MP0005397_hematopoietic_system_phenotyp1.26549291
60MP0001545_abnormal_hematopoietic_system1.26549291
61MP0000566_synostosis1.25569864
62MP0002420_abnormal_adaptive_immunity1.25408614
63MP0010368_abnormal_lymphatic_system1.25365136
64MP0009384_cardiac_valve_regurgitation1.25095241
65MP0003300_gastrointestinal_ulcer1.24542790
66MP0003941_abnormal_skin_development1.22920373
67MP0000689_abnormal_spleen_morphology1.22903421
68MP0001819_abnormal_immune_cell1.22315989
69MP0005000_abnormal_immune_tolerance1.19765604
70MP0006054_spinal_hemorrhage1.16983453
71MP0002723_abnormal_immune_serum1.15156961
72MP0005174_abnormal_tail_pigmentation1.13332000
73MP0001440_abnormal_grooming_behavior1.11184226
74MP0000015_abnormal_ear_pigmentation1.10299277
75MP0000762_abnormal_tongue_morphology1.09816941
76MP0002405_respiratory_system_inflammati1.09438996
77MP0004185_abnormal_adipocyte_glucose1.07711783
78MP0002933_joint_inflammation1.06703273
79MP0002429_abnormal_blood_cell1.05207222
80MP0002452_abnormal_antigen_presenting1.04794589
81MP0005076_abnormal_cell_differentiation1.04344292
82MP0002254_reproductive_system_inflammat1.02141442
83MP0001851_eye_inflammation1.01846222
84MP0005647_abnormal_sex_gland1.01158848
85MP0000465_gastrointestinal_hemorrhage0.93868174
86MP0003191_abnormal_cellular_cholesterol0.92478964
87MP0005025_abnormal_response_to0.91745094
88MP0003828_pulmonary_edema0.91095685
89MP0002019_abnormal_tumor_incidence0.89661539
90MP0005075_abnormal_melanosome_morpholog0.89479517
91MP0002163_abnormal_gland_morphology0.88225556
92MP0008004_abnormal_stomach_pH0.87975012
93MP0003566_abnormal_cell_adhesion0.87849293
94MP0002396_abnormal_hematopoietic_system0.87349685
95MP0008961_abnormal_basal_metabolism0.86892355
96MP0006138_congestive_heart_failure0.86776438
97MP0001984_abnormal_olfaction0.86117008
98MP0002009_preneoplasia0.81498171
99MP0005646_abnormal_pituitary_gland0.80585144
100MP0006276_abnormal_autonomic_nervous0.79076632
101MP0002075_abnormal_coat/hair_pigmentati0.76618761
102MP0001784_abnormal_fluid_regulation0.76393112
103MP0001853_heart_inflammation0.74021707
104MP0001845_abnormal_inflammatory_respons0.73155535
105MP0003724_increased_susceptibility_to0.71088367
106MP0002148_abnormal_hypersensitivity_rea0.71076960
107MP0003303_peritoneal_inflammation0.70453022
108MP0000750_abnormal_muscle_regeneration0.69875794
109MP0005023_abnormal_wound_healing0.68915709
110MP0004130_abnormal_muscle_cell0.68000694
111MP0009115_abnormal_fat_cell0.67905756
112MP0004215_abnormal_myocardial_fiber0.66095397
113MP0003950_abnormal_plasma_membrane0.64598211
114MP0005503_abnormal_tendon_morphology0.64591616
115MP0001542_abnormal_bone_strength0.63871939
116MP0000490_abnormal_crypts_of0.60883308
117MP0009053_abnormal_anal_canal0.60341960
118MP0003693_abnormal_embryo_hatching0.58543592
119MP0001186_pigmentation_phenotype0.58503436
120MP0008770_decreased_survivor_rate0.58303033
121MP0000013_abnormal_adipose_tissue0.57928391
122MP0005379_endocrine/exocrine_gland_phen0.56907606
123MP0003011_delayed_dark_adaptation0.56603875
124MP0003436_decreased_susceptibility_to0.56246787
125MP0002234_abnormal_pharynx_morphology0.56142789
126MP0003279_aneurysm0.55662226
127MP0002653_abnormal_ependyma_morphology0.55470880
128MP0002970_abnormal_white_adipose0.54361459
129MP0004484_altered_response_of0.54157344
130MP0001340_abnormal_eyelid_morphology0.54023059
131MP0006082_CNS_inflammation0.53413794
132MP0004957_abnormal_blastocyst_morpholog0.53148987
133MP0001919_abnormal_reproductive_system0.50477685
134MP0000627_abnormal_mammary_gland0.49814512
135MP0002998_abnormal_bone_remodeling0.49007792
136MP0004510_myositis0.48128106
137MP0004084_abnormal_cardiac_muscle0.45797113
138MP0001544_abnormal_cardiovascular_syste0.43476062
139MP0005385_cardiovascular_system_phenoty0.43476062
140MP0000230_abnormal_systemic_arterial0.40282776
141MP0002877_abnormal_melanocyte_morpholog0.38966332
142MP0000371_diluted_coat_color0.37104962
143MP0001765_abnormal_ion_homeostasis0.36458904
144MP0005375_adipose_tissue_phenotype0.35390996
145MP0000613_abnormal_salivary_gland0.35148581
146MP0002133_abnormal_respiratory_system0.33951688
147MP0005388_respiratory_system_phenotype0.33951688
148MP0009780_abnormal_chondrocyte_physiolo0.33283494
149MP0002277_abnormal_respiratory_mucosa0.32591013
150MP0002108_abnormal_muscle_morphology0.32418083
151MP0001873_stomach_inflammation0.31335552
152MP0002972_abnormal_cardiac_muscle0.30543781
153MP0004019_abnormal_vitamin_homeostasis0.30393623

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)8.88195030
2B lymphocytopenia (HP:0010976)8.88195030
3T lymphocytopenia (HP:0005403)8.09594236
4Abnormality of T cell number (HP:0011839)7.67267709
5Hypoplasia of the thymus (HP:0000778)7.16882543
6Thyroiditis (HP:0100646)7.08305208
7Abnormality of nail color (HP:0100643)7.03462352
8Severe combined immunodeficiency (HP:0004430)6.95096854
9Panhypogammaglobulinemia (HP:0003139)6.74042583
10Abnormality of the axillary hair (HP:0100134)6.29417282
11Abnormality of secondary sexual hair (HP:0009888)6.29417282
12Erythroderma (HP:0001019)6.21968602
13Eosinophilia (HP:0001880)6.18585710
14Combined immunodeficiency (HP:0005387)6.17041690
15Recurrent viral infections (HP:0004429)5.68320759
16Hypoproteinemia (HP:0003075)5.27717377
17Granulocytopenia (HP:0001913)4.98348746
18Increased IgE level (HP:0003212)4.93177000
19Hypotrichosis (HP:0001006)4.75529598
20Abnormality of eosinophils (HP:0001879)4.41301641
21Thick nail (HP:0001805)4.37904129
22Absent eyelashes (HP:0000561)4.37849189
23Woolly hair (HP:0002224)4.13421071
24Palmoplantar hyperkeratosis (HP:0000972)4.07975012
25Abnormality of T cells (HP:0002843)4.03496960
26Plantar hyperkeratosis (HP:0007556)3.99437763
27Aplasia involving bones of the extremities (HP:0009825)3.94602980
28Aplasia involving bones of the upper limbs (HP:0009823)3.94602980
29Aplasia of the phalanges of the hand (HP:0009802)3.94602980
30Dry hair (HP:0011359)3.92864843
31Palmar hyperkeratosis (HP:0010765)3.81260891
32Absent hair (HP:0002298)3.65360945
33Recurrent fungal infections (HP:0002841)3.59202836
34Verrucae (HP:0200043)3.56993791
35Papilloma (HP:0012740)3.56993791
36IgG deficiency (HP:0004315)3.52804350
37Oral leukoplakia (HP:0002745)3.52546360
38Onycholysis (HP:0001806)3.41837001
39Abnormality of the dental root (HP:0006486)3.35134478
40Taurodontia (HP:0000679)3.35134478
41Abnormality of permanent molar morphology (HP:0011071)3.35134478
42Leukocytosis (HP:0001974)3.27148999
43Milia (HP:0001056)3.14408792
44Abnormality of molar morphology (HP:0011070)3.12684114
45Abnormality of molar (HP:0011077)3.12684114
46Selective tooth agenesis (HP:0001592)3.07484536
47Nail dystrophy (HP:0008404)3.02194655
48Abnormality of the dental pulp (HP:0006479)2.97970223
49Long nose (HP:0003189)2.95766028
50Fragile nails (HP:0001808)2.95221775
51Abnormality of the salivary glands (HP:0010286)2.91746694
52Erythema (HP:0010783)2.90518374
53Hyporeflexia of lower limbs (HP:0002600)2.84247768
54Alopecia of scalp (HP:0002293)2.82148771
55Pili torti (HP:0003777)2.80923791
56Short middle phalanx of the 5th finger (HP:0004220)2.80902789
57Aplasia/Hypoplasia of the thymus (HP:0010515)2.71076514
58Conjunctival hamartoma (HP:0100780)2.70198943
59Parakeratosis (HP:0001036)2.68934678
60Sepsis (HP:0100806)2.63668828
61Abnormality of the columella (HP:0009929)2.58194879
62Abnormal blistering of the skin (HP:0008066)2.56849862
63Tetraparesis (HP:0002273)2.47526612
64Abnormality of the neuromuscular junction (HP:0003398)2.45609340
65Fatigable weakness (HP:0003473)2.45609340
66Abnormality of the fingertips (HP:0001211)2.43650518
67Meningitis (HP:0001287)2.43019270
68Curly hair (HP:0002212)2.38887186
69Conical tooth (HP:0000698)2.38710855
70Follicular hyperkeratosis (HP:0007502)2.36097143
71Nasolacrimal duct obstruction (HP:0000579)2.35098570
72Pruritus (HP:0000989)2.34843893
73Abnormality of the thymus (HP:0000777)2.33097229
74Right ventricular cardiomyopathy (HP:0011663)2.32943473
75Fine hair (HP:0002213)2.32322245
76Hypoplastic labia majora (HP:0000059)2.31901282
77Ridged nail (HP:0001807)2.30655549
78Absent eyebrow (HP:0002223)2.29245646
79Slow-growing hair (HP:0002217)2.20764282
80Abnormality of hair growth rate (HP:0011363)2.20764282
81Congenital ichthyosiform erythroderma (HP:0007431)2.17887143
82Lip pit (HP:0100267)2.12869685
83Abnormality of the labia majora (HP:0012881)2.12478765
84Ectropion (HP:0000656)2.12361286
85Elevated erythrocyte sedimentation rate (HP:0003565)2.12249545
86Gangrene (HP:0100758)2.11477575
87Oligodontia (HP:0000677)2.11261433
88Melanocytic nevus (HP:0000995)2.07560811
89Furrowed tongue (HP:0000221)2.06134310
90Hypergammaglobulinemia (HP:0010702)2.01869629
91Atrioventricular block (HP:0001678)1.97655262
92Sparse scalp hair (HP:0002209)1.97369663
93Abnormal hair laboratory examination (HP:0003328)1.96871358
94Split foot (HP:0001839)1.95969093
95Blepharitis (HP:0000498)1.95106875
96Abnormality of the lacrimal duct (HP:0011481)1.93493188
97Duplicated collecting system (HP:0000081)1.90614868
98Anonychia (HP:0001798)1.86935283
99Agammaglobulinemia (HP:0004432)1.86372893
100Abnormal auditory evoked potentials (HP:0006958)1.83389412
101Skin ulcer (HP:0200042)1.83143567
102Abnormality of the nasolacrimal system (HP:0000614)1.80905505
103Urticaria (HP:0001025)1.80425406
104Recurrent bronchitis (HP:0002837)1.78531810
105Palmoplantar keratoderma (HP:0000982)1.78187480
106Abnormality of the renal collecting system (HP:0004742)1.76124114
107Lymphoma (HP:0002665)1.74013694
108Abnormal delayed hypersensitivity skin test (HP:0002963)1.73807568
109Chronic otitis media (HP:0000389)1.71851445
110Mixed hearing impairment (HP:0000410)1.71517831
111Volvulus (HP:0002580)1.71368945
112Brittle hair (HP:0002299)1.68176560
113Bicuspid aortic valve (HP:0001647)1.67886988
114Broad alveolar ridges (HP:0000187)1.67822559
115Acanthosis nigricans (HP:0000956)1.66891114
116Xerostomia (HP:0000217)1.66372392
117Breast hypoplasia (HP:0003187)1.65147542
118Abnormality of cells of the erythroid lineage (HP:0012130)1.65058160
119Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64101557
120Lack of skin elasticity (HP:0100679)1.63347712
121Median cleft lip (HP:0000161)1.63269590
122Cellulitis (HP:0100658)1.62739871
123Deep philtrum (HP:0002002)1.62734447
124Hamartoma of the eye (HP:0010568)1.61916462
125Autoimmune thrombocytopenia (HP:0001973)1.61869629
126Anhidrosis (HP:0000970)1.60255492
127Basal cell carcinoma (HP:0002671)1.59699372
128Hyperhidrosis (HP:0000975)1.58970745
129Dehydration (HP:0001944)1.58495921
130Autoimmune hemolytic anemia (HP:0001890)1.57856085
131Popliteal pterygium (HP:0009756)1.57344887
132Cellular immunodeficiency (HP:0005374)1.56892096
133Non-midline cleft lip (HP:0100335)1.56122826
134Depressed nasal tip (HP:0000437)1.56020584
135Dry skin (HP:0000958)1.55834995
136Areflexia of lower limbs (HP:0002522)1.55828623
137Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.55582405
138Abnormality of the fingernails (HP:0001231)1.55454120
139Sparse eyelashes (HP:0000653)1.55191464
140Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.54645792
141Hamartoma (HP:0010566)1.53826774
142Abnormal number of erythroid precursors (HP:0012131)1.53299275
143Laryngomalacia (HP:0001601)1.53141181
144Eczematoid dermatitis (HP:0000976)1.52823282
145Pustule (HP:0200039)1.52808764
146Corneal erosion (HP:0200020)1.52465169
147Craniofacial hyperostosis (HP:0004493)1.51542994
148Sensory axonal neuropathy (HP:0003390)1.50009875
149Hypohidrosis (HP:0000966)1.49368592
150Abnormality of small intestinal villus morphology (HP:0011472)1.46634889
151Ventricular tachycardia (HP:0004756)1.46422129
152Cutis marmorata (HP:0000965)1.41660006
153Colitis (HP:0002583)1.40858020
154Gastrointestinal inflammation (HP:0004386)1.40699481
155Advanced eruption of teeth (HP:0006288)1.39192287
156Abnormality of the gastric mucosa (HP:0004295)1.38706720
157Nasal polyposis (HP:0100582)1.37780326
158Inflammation of the large intestine (HP:0002037)1.32958782
159Aplasia cutis congenita (HP:0001057)1.32485543

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK246.17671899
2MAP4K14.15437956
3MST43.61466192
4MAP3K103.32921964
5TXK3.19084303
6TGFBR13.16313135
7GRK63.14447080
8EEF2K3.08434887
9MAP3K62.90490543
10PKN22.69205585
11FRK2.66452304
12MAP3K22.62425791
13ZAP702.47323447
14PINK12.45369903
15LATS12.43582449
16SYK2.40591487
17TRIB32.36594110
18MAP3K72.32441235
19YES12.32292405
20IRAK42.31697034
21IRAK22.27118264
22RPS6KB22.25188819
23STK102.23695231
24EPHA22.21559835
25TAOK32.16332681
26ITK2.05134099
27ERN12.04383392
28PDGFRB1.99487232
29CDK121.96421810
30LRRK21.94916665
31MAPK71.92175795
32PIK3CA1.83657009
33MAP3K131.78891212
34FGFR31.74881678
35TYK21.73664605
36IRAK11.65004861
37FGFR21.63601259
38STK31.59993685
39MAPKAPK31.53910746
40PTK61.51907799
41IKBKE1.46167117
42CSK1.44611940
43NLK1.43541819
44FGFR41.40715617
45KIT1.38416684
46CDC71.35303595
47HCK1.34718118
48MAP3K91.28351141
49CLK11.27316276
50AKT31.27063397
51MAPK121.25347893
52CDK61.21657921
53TIE11.21417668
54PRKCH1.20065701
55MAP3K141.17182932
56IKBKB1.16848533
57MAPK41.16476440
58DAPK21.15151215
59OBSCN1.11920914
60LCK1.11620075
61TBK11.10633699
62RIPK41.08900972
63STK41.07125264
64RPS6KB11.06112426
65STK38L1.05898239
66NEK21.05790917
67RPS6KA41.04743067
68BLK1.04250006
69SGK2231.02898972
70SGK4941.02898972
71BTK0.99481951
72PRKCQ0.98496640
73HIPK20.98019764
74MARK20.94978994
75PDGFRA0.91795789
76CDK40.89926353
77PRKCE0.87782163
78SIK20.86738544
79EPHB10.84359174
80GRK70.83618041
81MARK30.82582218
82LATS20.77008626
83BRD40.75755797
84ERBB30.75698210
85CSNK1A1L0.74817337
86FGFR10.71469840
87SGK20.70443670
88MAPK110.70178910
89EIF2AK30.69680717
90PKN10.69574077
91TNK20.67651370
92PRKD10.66752304
93NEK60.66581592
94ADRBK10.66229514
95CSF1R0.65114677
96JAK20.65062059
97RIPK10.64641247
98MAP3K10.64353825
99TSSK60.63192995
100ICK0.62139619
101CDK90.60932812
102TGFBR20.58303815
103CHUK0.58251347
104MAP2K60.57123621
105MAP3K80.55979693
106FYN0.55930199
107CDK30.54154650
108CSNK1G30.53493522
109MYLK0.53198895
110INSR0.52058403
111MOS0.50739381
112MAPKAPK20.50304642
113CAMK10.49618058
114CDK190.49289681
115NTRK20.48984746
116FES0.48644383
117NME20.48621476
118JAK10.48536273
119EGFR0.47522342
120MAP3K30.47386161
121TEC0.47318127
122CAMK40.47248731
123DMPK0.44111911
124ALK0.43074816
125TAOK10.42962377
126CAMKK20.42854309
127CSNK1D0.40165401
128BRSK20.39751825
129PIM10.39734582
130DYRK1B0.37461893
131WNK10.37114088
132CHEK10.36920616
133MAPK90.35920696
134MAPK30.35721385
135PRKAA20.35338179
136TTN0.35121790
137ABL10.35107165
138CSNK1G20.34945215
139LYN0.34339240
140CSNK1G10.34063793
141TRPM70.33915486
142TESK20.33701939
143STK380.33341046
144MKNK20.32413874
145SGK10.32375701
146SGK30.32298956
147PIK3CG0.31871612
148PRKCI0.31848671
149FER0.31823218
150GRK50.31680061
151ILK0.31642467
152SIK10.30620580
153KDR0.29977203
154FGR0.29525536
155RPS6KA10.28469336
156MAP2K20.27493903
157MAP2K10.26321294
158RPS6KA20.26094865
159GRK10.25188674
160IGF1R0.24559246
161EPHA30.23479085

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.99629823
2Non-homologous end-joining_Homo sapiens_hsa034504.47758245
3T cell receptor signaling pathway_Homo sapiens_hsa046603.71394703
4Ovarian steroidogenesis_Homo sapiens_hsa049133.46332563
5Histidine metabolism_Homo sapiens_hsa003403.23073957
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.86543359
7Sphingolipid metabolism_Homo sapiens_hsa006002.57797081
8Antigen processing and presentation_Homo sapiens_hsa046122.57638028
9Ether lipid metabolism_Homo sapiens_hsa005652.38525999
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.25711299
11Arachidonic acid metabolism_Homo sapiens_hsa005902.23054658
12Hematopoietic cell lineage_Homo sapiens_hsa046402.15826903
13Thyroid cancer_Homo sapiens_hsa052162.13301591
14Acute myeloid leukemia_Homo sapiens_hsa052212.11357797
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.80089852
16B cell receptor signaling pathway_Homo sapiens_hsa046621.74717532
17Chronic myeloid leukemia_Homo sapiens_hsa052201.58947663
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.54398970
19Ribosome_Homo sapiens_hsa030101.50653526
20GnRH signaling pathway_Homo sapiens_hsa049121.48961132
21Dorso-ventral axis formation_Homo sapiens_hsa043201.48611017
22DNA replication_Homo sapiens_hsa030301.46428475
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43897812
24Endometrial cancer_Homo sapiens_hsa052131.43574111
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42494371
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.41816086
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.36900136
28Basal cell carcinoma_Homo sapiens_hsa052171.35967473
29Colorectal cancer_Homo sapiens_hsa052101.30136664
30HTLV-I infection_Homo sapiens_hsa051661.29153420
31Non-small cell lung cancer_Homo sapiens_hsa052231.28981603
32Measles_Homo sapiens_hsa051621.27140677
33Osteoclast differentiation_Homo sapiens_hsa043801.19027983
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17195621
35Inositol phosphate metabolism_Homo sapiens_hsa005621.16265241
36Prostate cancer_Homo sapiens_hsa052151.09753736
37Adherens junction_Homo sapiens_hsa045201.08303998
38Phototransduction_Homo sapiens_hsa047441.06665088
39MicroRNAs in cancer_Homo sapiens_hsa052061.05436733
40Long-term depression_Homo sapiens_hsa047301.05127739
41Olfactory transduction_Homo sapiens_hsa047401.03939709
42Salivary secretion_Homo sapiens_hsa049701.01987115
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00194635
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99901976
45Spliceosome_Homo sapiens_hsa030400.99472867
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.98890679
47Nitrogen metabolism_Homo sapiens_hsa009100.97547035
48Amoebiasis_Homo sapiens_hsa051460.95124435
49Base excision repair_Homo sapiens_hsa034100.94579612
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94371009
51Retinol metabolism_Homo sapiens_hsa008300.94013701
52ABC transporters_Homo sapiens_hsa020100.93830209
53Notch signaling pathway_Homo sapiens_hsa043300.93800281
54FoxO signaling pathway_Homo sapiens_hsa040680.93631056
55Herpes simplex infection_Homo sapiens_hsa051680.88435380
56VEGF signaling pathway_Homo sapiens_hsa043700.88038382
57Cell cycle_Homo sapiens_hsa041100.87742611
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87635465
59Proteoglycans in cancer_Homo sapiens_hsa052050.86603330
60Chemokine signaling pathway_Homo sapiens_hsa040620.86366181
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84712752
62ErbB signaling pathway_Homo sapiens_hsa040120.84649618
63Small cell lung cancer_Homo sapiens_hsa052220.83901287
64Serotonergic synapse_Homo sapiens_hsa047260.83586677
65Platelet activation_Homo sapiens_hsa046110.83557045
66Vitamin digestion and absorption_Homo sapiens_hsa049770.83046952
67Toxoplasmosis_Homo sapiens_hsa051450.83024251
68Hepatitis B_Homo sapiens_hsa051610.82444766
69Mismatch repair_Homo sapiens_hsa034300.81729380
70Chemical carcinogenesis_Homo sapiens_hsa052040.81158505
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.81076393
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.80884820
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80291294
74Pancreatic cancer_Homo sapiens_hsa052120.79793216
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79529641
76Viral carcinogenesis_Homo sapiens_hsa052030.78743468
77Collecting duct acid secretion_Homo sapiens_hsa049660.78479716
78Tuberculosis_Homo sapiens_hsa051520.78160963
79Glioma_Homo sapiens_hsa052140.77232652
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76232924
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74120636
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72000223
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71252735
84p53 signaling pathway_Homo sapiens_hsa041150.71035559
85Calcium signaling pathway_Homo sapiens_hsa040200.70885038
86Melanogenesis_Homo sapiens_hsa049160.70520235
87Lysine degradation_Homo sapiens_hsa003100.70302801
88Fatty acid elongation_Homo sapiens_hsa000620.68085732
89Mineral absorption_Homo sapiens_hsa049780.66702874
90Wnt signaling pathway_Homo sapiens_hsa043100.65418989
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65125833
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64687835
93Pathways in cancer_Homo sapiens_hsa052000.64368241
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64344163
95Bladder cancer_Homo sapiens_hsa052190.63770848
96ECM-receptor interaction_Homo sapiens_hsa045120.63746869
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63445091
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.62952575
99Estrogen signaling pathway_Homo sapiens_hsa049150.61991675
100Long-term potentiation_Homo sapiens_hsa047200.61891220
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60101257
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59530248
103beta-Alanine metabolism_Homo sapiens_hsa004100.58392328
104Tight junction_Homo sapiens_hsa045300.56632368
105PPAR signaling pathway_Homo sapiens_hsa033200.56393406
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.56208275
107Apoptosis_Homo sapiens_hsa042100.55493282
108Leishmaniasis_Homo sapiens_hsa051400.55249306
109Viral myocarditis_Homo sapiens_hsa054160.54541212
110mTOR signaling pathway_Homo sapiens_hsa041500.54267830
111mRNA surveillance pathway_Homo sapiens_hsa030150.54254279
112Pertussis_Homo sapiens_hsa051330.53089940
113Phenylalanine metabolism_Homo sapiens_hsa003600.52409526
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49913979
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49520547
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49436615
117Renal cell carcinoma_Homo sapiens_hsa052110.49385390
118Gap junction_Homo sapiens_hsa045400.48526075
119Insulin resistance_Homo sapiens_hsa049310.47790055
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47058023
121Influenza A_Homo sapiens_hsa051640.46698452
122Choline metabolism in cancer_Homo sapiens_hsa052310.46225515
123Renin-angiotensin system_Homo sapiens_hsa046140.45839337
124TNF signaling pathway_Homo sapiens_hsa046680.45560454
125HIF-1 signaling pathway_Homo sapiens_hsa040660.44726932
126Pancreatic secretion_Homo sapiens_hsa049720.44356463
127AMPK signaling pathway_Homo sapiens_hsa041520.44261262
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43403378
129Pentose phosphate pathway_Homo sapiens_hsa000300.42088123
130Caffeine metabolism_Homo sapiens_hsa002320.41670340
131Taste transduction_Homo sapiens_hsa047420.41248865
132Renin secretion_Homo sapiens_hsa049240.40869696
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40343612
134Rap1 signaling pathway_Homo sapiens_hsa040150.39975491
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39613068
136Epstein-Barr virus infection_Homo sapiens_hsa051690.39154022
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37568714
138Shigellosis_Homo sapiens_hsa051310.37398633
139Gastric acid secretion_Homo sapiens_hsa049710.37200991
140Ras signaling pathway_Homo sapiens_hsa040140.36560708
141Hepatitis C_Homo sapiens_hsa051600.36179708
142Insulin signaling pathway_Homo sapiens_hsa049100.35778010
143Endocytosis_Homo sapiens_hsa041440.35556952
144Linoleic acid metabolism_Homo sapiens_hsa005910.33161851
145MAPK signaling pathway_Homo sapiens_hsa040100.32711896
146Focal adhesion_Homo sapiens_hsa045100.32602206
147Staphylococcus aureus infection_Homo sapiens_hsa051500.31812870
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.31192163
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30851781
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29524520
151Oxytocin signaling pathway_Homo sapiens_hsa049210.29189873
152Circadian rhythm_Homo sapiens_hsa047100.29094915

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