ENDOV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.74169897
2DNA deamination (GO:0045006)7.88645208
3proline metabolic process (GO:0006560)7.25786115
4transcription from mitochondrial promoter (GO:0006390)7.00519945
5replication fork processing (GO:0031297)6.98818359
6positive regulation of protein homooligomerization (GO:0032464)6.87608256
7oxidative demethylation (GO:0070989)6.54462400
8embryonic process involved in female pregnancy (GO:0060136)6.40625010
9DNA strand renaturation (GO:0000733)6.14421281
10regulation of protein homooligomerization (GO:0032462)6.04836829
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.76534553
12poly(A)+ mRNA export from nucleus (GO:0016973)5.58119543
13regulation of integrin activation (GO:0033623)5.20434531
14establishment of apical/basal cell polarity (GO:0035089)5.05901508
15pyrimidine nucleobase catabolic process (GO:0006208)4.98498653
16mitochondrial DNA metabolic process (GO:0032042)4.74627966
17establishment or maintenance of monopolar cell polarity (GO:0061339)4.71359650
18establishment of monopolar cell polarity (GO:0061162)4.71359650
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.60198471
20DNA integration (GO:0015074)4.56808994
21viral mRNA export from host cell nucleus (GO:0046784)4.50364180
22negative regulation of protein oligomerization (GO:0032460)4.45125845
23negative regulation of JAK-STAT cascade (GO:0046426)4.33247281
24mRNA cleavage (GO:0006379)4.33195276
25somatic hypermutation of immunoglobulin genes (GO:0016446)4.32631748
26somatic diversification of immune receptors via somatic mutation (GO:0002566)4.32631748
27embryonic camera-type eye development (GO:0031076)4.28543399
28behavioral response to nicotine (GO:0035095)4.27079404
29cellular response to zinc ion (GO:0071294)4.21641410
30cellular response to ATP (GO:0071318)4.18863458
31face development (GO:0060324)4.13997884
32negative regulation of Ras GTPase activity (GO:0034261)4.07351077
33nucleobase catabolic process (GO:0046113)4.04503444
34negative regulation of mRNA processing (GO:0050686)4.03930828
35convergent extension (GO:0060026)3.99543777
36base-excision repair (GO:0006284)3.99338204
37DNA double-strand break processing (GO:0000729)3.97036506
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.96651707
39histone H4-K12 acetylation (GO:0043983)3.95531707
40response to pheromone (GO:0019236)3.91294952
41negative regulation of cell cycle arrest (GO:0071157)3.91074152
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.88262871
43synaptic vesicle endocytosis (GO:0048488)3.77107571
44glial cell migration (GO:0008347)3.77072214
45positive regulation of developmental pigmentation (GO:0048087)3.76323836
46DNA demethylation (GO:0080111)3.73075152
47activation of Rac GTPase activity (GO:0032863)3.72943935
48nonmotile primary cilium assembly (GO:0035058)3.72713338
49spliceosomal tri-snRNP complex assembly (GO:0000244)3.72665544
50protein complex biogenesis (GO:0070271)3.70026185
51embryonic placenta development (GO:0001892)3.68987143
52NADH dehydrogenase complex assembly (GO:0010257)3.67797284
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67797284
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.67797284
55pyrimidine nucleotide catabolic process (GO:0006244)3.65666366
56preassembly of GPI anchor in ER membrane (GO:0016254)3.65498479
57telomere maintenance via semi-conservative replication (GO:0032201)3.63213377
58regulation of translational fidelity (GO:0006450)3.62109440
59protein localization to cilium (GO:0061512)3.61971530
60mannosylation (GO:0097502)3.60283884
61base-excision repair, AP site formation (GO:0006285)3.58929887
62epithelial cilium movement (GO:0003351)3.58466102
63mitotic G1 DNA damage checkpoint (GO:0031571)3.54728743
64regulation of protein oligomerization (GO:0032459)3.53192413
65negative regulation of RNA splicing (GO:0033119)3.48334290
66axoneme assembly (GO:0035082)3.48050132
67protein polyglutamylation (GO:0018095)3.45690506
68regulation of double-strand break repair via homologous recombination (GO:0010569)3.44022010
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43956733
70regulation of respiratory system process (GO:0044065)3.43907806
71postsynaptic membrane organization (GO:0001941)3.42514515
72gamma-aminobutyric acid transport (GO:0015812)3.41562098
73anatomical structure regression (GO:0060033)3.41291348
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.37877680
75positive regulation of protein oligomerization (GO:0032461)3.37621562
76kinetochore assembly (GO:0051382)3.35227224
77mitochondrial respiratory chain complex assembly (GO:0033108)3.34313962
78dosage compensation (GO:0007549)3.34141417
79auditory receptor cell stereocilium organization (GO:0060088)3.33671571
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31299316
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31299316
82spinal cord development (GO:0021510)3.30718220
83positive regulation of DNA repair (GO:0045739)3.29989692
84non-recombinational repair (GO:0000726)3.29019203
85double-strand break repair via nonhomologous end joining (GO:0006303)3.29019203
86termination of RNA polymerase II transcription (GO:0006369)3.25884641
87glutamine family amino acid biosynthetic process (GO:0009084)3.25593447
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.25026469
89iron-sulfur cluster assembly (GO:0016226)3.24666554
90metallo-sulfur cluster assembly (GO:0031163)3.24666554
91positive regulation of mitochondrial fission (GO:0090141)3.23553130
92DNA ligation (GO:0006266)3.20960248
93regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.20607123
94signal complex assembly (GO:0007172)3.16126566
95G1 DNA damage checkpoint (GO:0044783)3.15648074
96regulation of cilium movement (GO:0003352)3.15072288
97negative regulation of heart rate (GO:0010459)3.13290275
98positive regulation by host of viral transcription (GO:0043923)3.12766449
99embryonic eye morphogenesis (GO:0048048)3.12524474
100mitochondrial RNA metabolic process (GO:0000959)3.08581495
101mRNA polyadenylation (GO:0006378)3.07337641
102regulation of cAMP-dependent protein kinase activity (GO:2000479)3.05118995
103cilium movement (GO:0003341)3.04220828
104amino acid salvage (GO:0043102)3.03858122
105L-methionine salvage (GO:0071267)3.03858122
106L-methionine biosynthetic process (GO:0071265)3.03858122
107platelet dense granule organization (GO:0060155)3.03835463
108cornea development in camera-type eye (GO:0061303)3.02497644
109cilium morphogenesis (GO:0060271)3.01121423
110neuromuscular process controlling posture (GO:0050884)3.00969443
111mitotic G1/S transition checkpoint (GO:0044819)3.00482481
112V(D)J recombination (GO:0033151)3.00143902
113DNA topological change (GO:0006265)2.99987830
114synaptic transmission, cholinergic (GO:0007271)2.99769560
115negative regulation of mRNA metabolic process (GO:1903312)2.99586717
116neuron fate specification (GO:0048665)2.99152600
117meiotic chromosome segregation (GO:0045132)2.98649733
118fucose catabolic process (GO:0019317)2.97397779
119L-fucose metabolic process (GO:0042354)2.97397779
120L-fucose catabolic process (GO:0042355)2.97397779
121glandular epithelial cell development (GO:0002068)2.96453668
122regulation of hippo signaling (GO:0035330)2.95399585
123establishment of mitochondrion localization (GO:0051654)2.93996865
124negative regulation of mast cell activation (GO:0033004)2.93425747
125intraciliary transport (GO:0042073)2.92549495
126C-terminal protein lipidation (GO:0006501)2.92366329
127positive regulation of receptor recycling (GO:0001921)2.91993824
128maturation of 5.8S rRNA (GO:0000460)2.91867079
129negative regulation of chondrocyte differentiation (GO:0032331)2.91254492
130regulation of DNA damage checkpoint (GO:2000001)2.91118803
131ubiquinone biosynthetic process (GO:0006744)2.90786020
132regulation of double-strand break repair (GO:2000779)2.89805320
133telomere maintenance via recombination (GO:0000722)2.87626001
134respiratory chain complex IV assembly (GO:0008535)2.87208933
135peptidyl-histidine modification (GO:0018202)2.87140362
136negative regulation of telomere maintenance (GO:0032205)2.86421459
137GDP-mannose metabolic process (GO:0019673)2.85182187
138neuron cell-cell adhesion (GO:0007158)2.84990284
139C-terminal protein amino acid modification (GO:0018410)2.84661189
140apoptotic process involved in morphogenesis (GO:0060561)2.82916545
141positive regulation of mitotic sister chromatid separation (GO:1901970)2.82877598
142positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82877598
143positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82877598
144head development (GO:0060322)2.82376865
145regulation of microtubule-based movement (GO:0060632)2.81106800
146RNA polyadenylation (GO:0043631)2.80756081
147regulation of RNA export from nucleus (GO:0046831)2.79237453
148cilium organization (GO:0044782)2.79029802
149epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78681115
150cilium assembly (GO:0042384)2.74521904
151detection of light stimulus involved in visual perception (GO:0050908)2.71447681
152detection of light stimulus involved in sensory perception (GO:0050962)2.71447681
153ubiquinone metabolic process (GO:0006743)2.68577814
154regulation of hexokinase activity (GO:1903299)2.65946536
155regulation of glucokinase activity (GO:0033131)2.65946536
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65253505
157cytochrome complex assembly (GO:0017004)2.64536124
158GPI anchor metabolic process (GO:0006505)2.64384438
159positive regulation of oligodendrocyte differentiation (GO:0048714)2.62603726
160mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62591040
161regulation of feeding behavior (GO:0060259)2.60508058
162somite development (GO:0061053)2.60051850
163negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59919401
164ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.58172336
165cilium or flagellum-dependent cell motility (GO:0001539)2.55642638
166glycosphingolipid biosynthetic process (GO:0006688)2.54235761
167chaperone-mediated protein transport (GO:0072321)2.53896905
168neurotransmitter catabolic process (GO:0042135)2.52525477
169ATP synthesis coupled proton transport (GO:0015986)2.52011988
170energy coupled proton transport, down electrochemical gradient (GO:0015985)2.52011988
171indolalkylamine catabolic process (GO:0046218)2.51571985
172tryptophan catabolic process (GO:0006569)2.51571985
173indole-containing compound catabolic process (GO:0042436)2.51571985
174protein localization to synapse (GO:0035418)2.50105713
175piRNA metabolic process (GO:0034587)2.49838855
176pseudouridine synthesis (GO:0001522)2.49229582
177photoreceptor cell maintenance (GO:0045494)2.47954770
178indolalkylamine metabolic process (GO:0006586)2.46942003
179presynaptic membrane assembly (GO:0097105)2.46915257
180transmission of nerve impulse (GO:0019226)2.46888370
181startle response (GO:0001964)2.46582100
182auditory behavior (GO:0031223)2.46199335
183neurotransmitter metabolic process (GO:0042133)2.45976581
184neuronal action potential propagation (GO:0019227)2.45806523
185protein import into peroxisome matrix (GO:0016558)2.44642668
186tRNA processing (GO:0008033)2.44616646
187synaptic vesicle maturation (GO:0016188)2.44365161
188regulation of mitochondrial fission (GO:0090140)2.43762608
189G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43096173
190protein deneddylation (GO:0000338)2.42817249
191anterograde synaptic vesicle transport (GO:0048490)2.39878723
192kynurenine metabolic process (GO:0070189)2.37665949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.87961913
2ZNF274_21170338_ChIP-Seq_K562_Hela4.06326009
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse4.02015276
4SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.00759242
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.98607051
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.96729005
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93708601
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74508482
9VDR_21846776_ChIP-Seq_THP-1_Human2.71806698
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.67649102
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64759524
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64299887
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63321342
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57085010
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.55140422
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.55140422
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.55140422
18SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.47926745
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.41805075
20LXR_22292898_ChIP-Seq_THP-1_Human2.36444394
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30703765
22IGF1R_20145208_ChIP-Seq_DFB_Human2.27488293
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.25644864
24POU5F1_16518401_ChIP-PET_MESCs_Mouse2.19831231
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.15523318
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.15293827
27GBX2_23144817_ChIP-Seq_PC3_Human2.13257122
28VDR_22108803_ChIP-Seq_LS180_Human2.06730051
29ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01088872
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.00593434
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.98572755
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96532633
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.96200571
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.96184498
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.93888293
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93840007
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92952329
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.92739179
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.88009673
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.87525721
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84430943
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80281640
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.78255025
44PU.1_20513432_ChIP-Seq_Bcells_Mouse1.77942223
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76725489
46MYC_22102868_ChIP-Seq_BL_Human1.75652670
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74769732
48IRF1_19129219_ChIP-ChIP_H3396_Human1.73686432
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.73542445
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.70707270
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.70077943
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.68355984
53TP53_22573176_ChIP-Seq_HFKS_Human1.64406790
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.60148207
55MYC_18940864_ChIP-ChIP_HL60_Human1.58728617
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.55567717
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.55333353
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55242605
59KDM2B_26808549_Chip-Seq_DND41_Human1.52885052
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52075609
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.50089023
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49927218
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.49584945
64EWS_26573619_Chip-Seq_HEK293_Human1.49548046
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45416131
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44647192
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.43911181
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43315360
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43284555
70KDM2B_26808549_Chip-Seq_K562_Human1.43247374
71VDR_23849224_ChIP-Seq_CD4+_Human1.43207287
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.42321847
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42168158
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41972875
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41389548
76RACK7_27058665_Chip-Seq_MCF-7_Human1.40577190
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40417072
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39591099
79GABP_19822575_ChIP-Seq_HepG2_Human1.38402363
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38356202
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36966378
82TAF15_26573619_Chip-Seq_HEK293_Human1.35793813
83ETS1_21867929_ChIP-Seq_TH2_Mouse1.35375816
84ERA_21632823_ChIP-Seq_H3396_Human1.34772386
85RNF2_27304074_Chip-Seq_NSC_Mouse1.32702153
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31224556
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30911302
88RARB_24833708_ChIP-Seq_LIVER_Mouse1.29634057
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26980982
90PHF8_20622854_ChIP-Seq_HELA_Human1.26968201
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25174743
92P300_19829295_ChIP-Seq_ESCs_Human1.25030646
93POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24768447
94CTCF_27219007_Chip-Seq_Bcells_Human1.24499959
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.24477974
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24143349
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23833877
98FUS_26573619_Chip-Seq_HEK293_Human1.23746395
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22792327
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.22489042
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21901037
102E2F1_20622854_ChIP-Seq_HELA_Human1.21511309
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21086002
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19128063
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.18563754
106SPI1_26923725_Chip-Seq_HPCs_Mouse1.18320255
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.17983297
108CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17930640
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17256600
110ER_23166858_ChIP-Seq_MCF-7_Human1.17190609
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16842282
112CBP_20019798_ChIP-Seq_JUKART_Human1.16842282
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.15474018
114RARA_24833708_ChIP-Seq_LIVER_Mouse1.15352506
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15238509
116EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15076175
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15032084
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.14514917
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.13463654
120MYC_19829295_ChIP-Seq_ESCs_Human1.13276183
121SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12950953
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12817458
123JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12671205
124P68_20966046_ChIP-Seq_HELA_Human1.12531372
125SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12520667
126EED_16625203_ChIP-ChIP_MESCs_Mouse1.12496558
127TET1_21490601_ChIP-Seq_MESCs_Mouse1.12247167
128RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12080643
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11950374
130BCAT_22108803_ChIP-Seq_LS180_Human1.11941434
131TP53_23651856_ChIP-Seq_MEFs_Mouse1.10775608
132SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10669329
133TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10101319
134BCL6_27268052_Chip-Seq_Bcells_Human1.09752857
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09719700
136SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09568467
137JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09567181
138FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09380789
139DROSHA_22980978_ChIP-Seq_HELA_Human1.09094519
140TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08955935
141ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08082004
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07927936
143NCOR_22424771_ChIP-Seq_293T_Human1.07833997
144FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07815858
145FOXA1_25329375_ChIP-Seq_VCAP_Human1.07815858
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06590826
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06148348
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06088048
149AR_25329375_ChIP-Seq_VCAP_Human1.04669757
150YY1_22570637_ChIP-Seq_MALME-3M_Human1.04499223
151SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.03961842
152SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03345642
153POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02673207
154SA1_27219007_Chip-Seq_ERYTHROID_Human1.02450099
155REST_21632747_ChIP-Seq_MESCs_Mouse1.01795945
156FOXP3_21729870_ChIP-Seq_TREG_Human1.01447828
157HOXB7_26014856_ChIP-Seq_BT474_Human1.00885351
158TAF2_19829295_ChIP-Seq_ESCs_Human1.00834945
159NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00620994
160CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00209848
161PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00069377
162RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99973598
163AR_20517297_ChIP-Seq_VCAP_Human0.99814891
164OCT4_20526341_ChIP-Seq_ESCs_Human0.99025206
165NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98622838
166SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98598956
167ELK3_25401928_ChIP-Seq_HUVEC_Human0.98377365
168MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98021275
169TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97789878
170RING1B_27294783_Chip-Seq_ESCs_Mouse0.96763296
171NANOG_20526341_ChIP-Seq_ESCs_Human0.96136942
172KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95802490
173CREB1_26743006_Chip-Seq_LNCaP_Human0.95707966
174JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95553777
175E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95529326
176BCOR_27268052_Chip-Seq_Bcells_Human0.95487466
177CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95023740
178P53_21459846_ChIP-Seq_SAOS-2_Human0.94204796
179RAC3_21632823_ChIP-Seq_H3396_Human0.93575940
180POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92731665
181TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92731665
182SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92620800
183CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90023529
184UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89796052
185KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88083757
186SOX2_19829295_ChIP-Seq_ESCs_Human0.86921937
187NANOG_19829295_ChIP-Seq_ESCs_Human0.86921937
188FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86791770
189KDM5A_27292631_Chip-Seq_BREAST_Human0.86776285
190STAT3_23295773_ChIP-Seq_U87_Human0.86048701
191TCF4_23295773_ChIP-Seq_U87_Human0.86017232
192* FOXP1_21924763_ChIP-Seq_HESCs_Human0.84785214
193SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84636382
194ELK1_19687146_ChIP-ChIP_HELA_Human0.84167424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.94897772
2MP0005171_absent_coat_pigmentation4.90201488
3MP0010030_abnormal_orbit_morphology4.19431713
4MP0009278_abnormal_bone_marrow3.56587182
5MP0002009_preneoplasia3.53607260
6MP0001968_abnormal_touch/_nociception2.96428255
7MP0002736_abnormal_nociception_after2.68512418
8MP0003283_abnormal_digestive_organ2.67599454
9MP0008995_early_reproductive_senescence2.67151813
10MP0004233_abnormal_muscle_weight2.63954067
11MP0005645_abnormal_hypothalamus_physiol2.55459096
12MP0005174_abnormal_tail_pigmentation2.47650849
13MP0002653_abnormal_ependyma_morphology2.46337423
14MP0002102_abnormal_ear_morphology2.41356071
15MP0003880_abnormal_central_pattern2.37076418
16MP0006072_abnormal_retinal_apoptosis2.22886930
17MP0002249_abnormal_larynx_morphology2.20065688
18MP0002735_abnormal_chemical_nociception2.15125496
19MP0000015_abnormal_ear_pigmentation2.14088323
20MP0006276_abnormal_autonomic_nervous2.12849187
21MP0005551_abnormal_eye_electrophysiolog2.10854741
22MP0003890_abnormal_embryonic-extraembry2.10384523
23MP0003119_abnormal_digestive_system2.06109839
24MP0004133_heterotaxia2.03878733
25MP0001293_anophthalmia1.96481338
26MP0000372_irregular_coat_pigmentation1.93570574
27MP0009745_abnormal_behavioral_response1.90450753
28MP0001986_abnormal_taste_sensitivity1.89999753
29MP0003136_yellow_coat_color1.89042630
30MP0002638_abnormal_pupillary_reflex1.85573623
31MP0003787_abnormal_imprinting1.84185159
32MP0001984_abnormal_olfaction1.83280413
33MP0008875_abnormal_xenobiotic_pharmacok1.74399330
34MP0005423_abnormal_somatic_nervous1.73711230
35MP0003646_muscle_fatigue1.71938068
36MP0002733_abnormal_thermal_nociception1.71862400
37MP0002272_abnormal_nervous_system1.71211147
38MP0010094_abnormal_chromosome_stability1.70670465
39MP0001970_abnormal_pain_threshold1.69354596
40MP0003786_premature_aging1.68772753
41MP0004147_increased_porphyrin_level1.67753627
42MP0001905_abnormal_dopamine_level1.65284505
43MP0003635_abnormal_synaptic_transmissio1.65242915
44MP0008872_abnormal_physiological_respon1.64544346
45MP0001486_abnormal_startle_reflex1.61789648
46MP0008877_abnormal_DNA_methylation1.61711426
47MP0002557_abnormal_social/conspecific_i1.58504874
48MP0005646_abnormal_pituitary_gland1.53247876
49MP0002734_abnormal_mechanical_nocicepti1.51142967
50MP0003195_calcinosis1.50990318
51MP0008058_abnormal_DNA_repair1.50414590
52MP0000462_abnormal_digestive_system1.49598814
53MP0002234_abnormal_pharynx_morphology1.48779844
54MP0000371_diluted_coat_color1.48378998
55MP0006292_abnormal_olfactory_placode1.47823117
56MP0002064_seizures1.46299101
57MP0005397_hematopoietic_system_phenotyp1.44648853
58MP0001545_abnormal_hematopoietic_system1.44648853
59MP0001529_abnormal_vocalization1.43580371
60MP0000579_abnormal_nail_morphology1.42794792
61MP0003121_genomic_imprinting1.42621539
62MP0004043_abnormal_pH_regulation1.40538596
63MP0004859_abnormal_synaptic_plasticity1.40093608
64MP0002282_abnormal_trachea_morphology1.39425200
65MP0000049_abnormal_middle_ear1.37966964
66MP0003111_abnormal_nucleus_morphology1.37710110
67MP0002067_abnormal_sensory_capabilities1.37158280
68MP0002075_abnormal_coat/hair_pigmentati1.35357306
69MP0005076_abnormal_cell_differentiation1.33637022
70MP0002751_abnormal_autonomic_nervous1.33618880
71MP0000516_abnormal_urinary_system1.29640317
72MP0005367_renal/urinary_system_phenotyp1.29640317
73MP0000678_abnormal_parathyroid_gland1.27612468
74MP0002837_dystrophic_cardiac_calcinosis1.26194507
75MP0001186_pigmentation_phenotype1.24653283
76MP0003172_abnormal_lysosome_physiology1.23027422
77MP0002876_abnormal_thyroid_physiology1.22756980
78MP0003011_delayed_dark_adaptation1.22523593
79MP0002084_abnormal_developmental_patter1.20595502
80MP0002822_catalepsy1.20557621
81MP0003122_maternal_imprinting1.18685349
82MP0005386_behavior/neurological_phenoty1.18097962
83MP0004924_abnormal_behavior1.18097962
84MP0005075_abnormal_melanosome_morpholog1.17647178
85MP0002752_abnormal_somatic_nervous1.16359044
86MP0003935_abnormal_craniofacial_develop1.15743777
87MP0002116_abnormal_craniofacial_bone1.15289000
88MP0002932_abnormal_joint_morphology1.15257364
89MP0000470_abnormal_stomach_morphology1.14971341
90MP0000026_abnormal_inner_ear1.14816552
91MP0002085_abnormal_embryonic_tissue1.10793722
92MP0002882_abnormal_neuron_morphology1.09648917
93MP0003755_abnormal_palate_morphology1.09424506
94MP0001501_abnormal_sleep_pattern1.04964592
95MP0004270_analgesia1.04912022
96MP0000778_abnormal_nervous_system1.03945453
97MP0002114_abnormal_axial_skeleton1.02918624
98MP0002909_abnormal_adrenal_gland1.02849828
99MP0001502_abnormal_circadian_rhythm1.00854049
100MP0003453_abnormal_keratinocyte_physiol1.00726504
101MP0001764_abnormal_homeostasis1.00266102
102MP0000566_synostosis1.00235402
103MP0005195_abnormal_posterior_eye1.00136132
104MP0005253_abnormal_eye_physiology0.99909407
105MP0004742_abnormal_vestibular_system0.99616256
106MP0004885_abnormal_endolymph0.99536183
107MP0000427_abnormal_hair_cycle0.99514051
108MP0001963_abnormal_hearing_physiology0.98955904
109MP0009053_abnormal_anal_canal0.97751842
110MP0000490_abnormal_crypts_of0.97676250
111MP0002086_abnormal_extraembryonic_tissu0.97503794
112MP0000762_abnormal_tongue_morphology0.97048322
113MP0002229_neurodegeneration0.96907610
114MP0001340_abnormal_eyelid_morphology0.96392224
115MP0010352_gastrointestinal_tract_polyps0.95326477
116MP0008932_abnormal_embryonic_tissue0.95199621
117MP0002938_white_spotting0.94836085
118MP0003942_abnormal_urinary_system0.92158212
119MP0000955_abnormal_spinal_cord0.92098258
120MP0002111_abnormal_tail_morphology0.92081469
121MP0004197_abnormal_fetal_growth/weight/0.92079244
122MP0005508_abnormal_skeleton_morphology0.92027986
123MP0000681_abnormal_thyroid_gland0.91369578
124MP0003385_abnormal_body_wall0.91187120
125MP0005391_vision/eye_phenotype0.90793365
126MP0001697_abnormal_embryo_size0.90556821
127MP0006036_abnormal_mitochondrial_physio0.90466667
128MP0000639_abnormal_adrenal_gland0.90368587
129MP0010386_abnormal_urinary_bladder0.89840291
130MP0008789_abnormal_olfactory_epithelium0.88928529
131MP0001485_abnormal_pinna_reflex0.88735012
132MP0001324_abnormal_eye_pigmentation0.87026906
133MP0003698_abnormal_male_reproductive0.86773719
134MP0005499_abnormal_olfactory_system0.86587633
135MP0005394_taste/olfaction_phenotype0.86587633
136MP0003718_maternal_effect0.84897570
137MP0002928_abnormal_bile_duct0.84124086
138MP0003861_abnormal_nervous_system0.84030442
139MP0004264_abnormal_extraembryonic_tissu0.80154012
140MP0003045_fibrosis0.79908142
141MP0003137_abnormal_impulse_conducting0.79735880
142MP0002066_abnormal_motor_capabilities/c0.79632838
143MP0001270_distended_abdomen0.79545371
144MP0000432_abnormal_head_morphology0.79175112
145MP0003938_abnormal_ear_development0.77690263
146MP0002572_abnormal_emotion/affect_behav0.76256665
147MP0005410_abnormal_fertilization0.74499839
148MP0003186_abnormal_redox_activity0.74427871
149MP0002063_abnormal_learning/memory/cond0.74384720
150MP0006035_abnormal_mitochondrial_morpho0.74344592
151MP0002163_abnormal_gland_morphology0.73697524
152MP0003077_abnormal_cell_cycle0.71176060
153MP0000631_abnormal_neuroendocrine_gland0.69858517
154MP0004957_abnormal_blastocyst_morpholog0.67740223
155MP0004134_abnormal_chest_morphology0.67605940
156MP0002184_abnormal_innervation0.67157546
157MP0000467_abnormal_esophagus_morphology0.66868843
158MP0005380_embryogenesis_phenotype0.64864731
159MP0001672_abnormal_embryogenesis/_devel0.64864731
160MP0000350_abnormal_cell_proliferation0.64675330
161MP0004811_abnormal_neuron_physiology0.64283365
162MP0009046_muscle_twitch0.64211985
163MP0004142_abnormal_muscle_tone0.61581626
164MP0002152_abnormal_brain_morphology0.61149025
165MP0002177_abnormal_outer_ear0.60852368
166MP0002697_abnormal_eye_size0.60018854
167MP0002092_abnormal_eye_morphology0.59432274

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.02087286
2Concave nail (HP:0001598)4.69200839
3Annular pancreas (HP:0001734)4.46597729
4Molar tooth sign on MRI (HP:0002419)4.36962612
5Abnormality of midbrain morphology (HP:0002418)4.36962612
6Increased IgM level (HP:0003496)4.26336092
7Intestinal atresia (HP:0011100)4.22065973
8Pustule (HP:0200039)4.21607909
9Pancreatic cysts (HP:0001737)4.16205402
10Turricephaly (HP:0000262)4.15268716
11True hermaphroditism (HP:0010459)4.10754257
12Rectal fistula (HP:0100590)4.08634186
13Rectovaginal fistula (HP:0000143)4.08634186
14Pancreatic fibrosis (HP:0100732)4.04406032
15Intestinal fistula (HP:0100819)4.00135363
16Facial hemangioma (HP:0000329)3.95395508
17Coronal craniosynostosis (HP:0004440)3.94175608
18Type II lissencephaly (HP:0007260)3.86210244
19Poikiloderma (HP:0001029)3.86089519
20Nephronophthisis (HP:0000090)3.75583826
21Medial flaring of the eyebrow (HP:0010747)3.73560004
22Vaginal fistula (HP:0004320)3.46414454
23Gait imbalance (HP:0002141)3.39676395
24Anteriorly placed anus (HP:0001545)3.37710420
25Retinal dysplasia (HP:0007973)3.29176677
26Congenital stationary night blindness (HP:0007642)3.28245648
27Alacrima (HP:0000522)3.24088884
28Alopecia of scalp (HP:0002293)3.23350671
29Ulnar bowing (HP:0003031)3.17732777
30Acute necrotizing encephalopathy (HP:0006965)3.10616747
31Congenital primary aphakia (HP:0007707)3.08893911
32Nephrogenic diabetes insipidus (HP:0009806)3.06841197
33Abnormality of the renal medulla (HP:0100957)3.05644422
34Abnormality of the aortic arch (HP:0012303)3.05226753
35Patellar aplasia (HP:0006443)3.02853919
36Hyperventilation (HP:0002883)3.02794602
37Abnormal mitochondria in muscle tissue (HP:0008316)2.96936840
38Narrow nasal bridge (HP:0000446)2.96469188
39Lissencephaly (HP:0001339)2.95194083
40Congenital hip dislocation (HP:0001374)2.93665321
41Hepatocellular necrosis (HP:0001404)2.92062684
42Mitochondrial inheritance (HP:0001427)2.91352743
43Large for gestational age (HP:0001520)2.88872895
44Abnormality of male internal genitalia (HP:0000022)2.87886219
45Absent radius (HP:0003974)2.87091590
46Aplasia/Hypoplasia of the patella (HP:0006498)2.86610380
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.86101834
48Tented upper lip vermilion (HP:0010804)2.84803155
49Cerebellar dysplasia (HP:0007033)2.83397632
50Increased CSF lactate (HP:0002490)2.82009724
51Cystic liver disease (HP:0006706)2.81860809
52Tongue fasciculations (HP:0001308)2.81763378
53Hepatic necrosis (HP:0002605)2.80947899
54Acute lymphatic leukemia (HP:0006721)2.78229434
55Acute encephalopathy (HP:0006846)2.76201771
56Absent forearm bone (HP:0003953)2.75104616
57Aplasia involving forearm bones (HP:0009822)2.75104616
58Sclerocornea (HP:0000647)2.69955856
59Decreased lacrimation (HP:0000633)2.68632351
60Abnormality of polysaccharide metabolism (HP:0011012)2.67898159
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67898159
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67898159
63Albinism (HP:0001022)2.65273062
64Hypotelorism (HP:0000601)2.64615470
65Urinary glycosaminoglycan excretion (HP:0003541)2.64239717
66Mucopolysacchariduria (HP:0008155)2.64239717
67Vertebral hypoplasia (HP:0008417)2.60234969
68Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.60234969
69Volvulus (HP:0002580)2.59005903
70Abnormality of the renal cortex (HP:0011035)2.54672909
71Short chin (HP:0000331)2.54044969
72Increased number of teeth (HP:0011069)2.52317654
73Short humerus (HP:0005792)2.52066065
74Hypokinesia (HP:0002375)2.51530784
75Progressive macrocephaly (HP:0004481)2.51142804
76Orthostatic hypotension (HP:0001278)2.50719505
77Broad alveolar ridges (HP:0000187)2.49169405
78Aplasia of the musculature (HP:0100854)2.47270623
79Growth hormone excess (HP:0000845)2.47194039
80Absent speech (HP:0001344)2.46387670
81Hamartoma (HP:0010566)2.45786281
82Hypochromic microcytic anemia (HP:0004840)2.45582324
83Male infertility (HP:0003251)2.45339088
84Severe muscular hypotonia (HP:0006829)2.44575819
85Aplasia/hypoplasia of the humerus (HP:0006507)2.44021644
86Pancreatic islet-cell hyperplasia (HP:0004510)2.43074199
87Gastrointestinal atresia (HP:0002589)2.41727038
88Absent thumb (HP:0009777)2.39629649
89Muscle fibrillation (HP:0010546)2.39307871
90Genital tract atresia (HP:0001827)2.37372331
91Premature graying of hair (HP:0002216)2.37243097
92Vaginal atresia (HP:0000148)2.36566900
93Pachygyria (HP:0001302)2.34170133
94Attenuation of retinal blood vessels (HP:0007843)2.32406113
95Bifid uvula (HP:0000193)2.29574760
96Anencephaly (HP:0002323)2.29245910
97Abnormality of alanine metabolism (HP:0010916)2.29048772
98Hyperalaninemia (HP:0003348)2.29048772
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29048772
100Polyphagia (HP:0002591)2.26461080
101Myokymia (HP:0002411)2.25854199
102Congenital hepatic fibrosis (HP:0002612)2.24825063
103Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24413402
104Abnormal respiratory epithelium morphology (HP:0012253)2.24166501
105Abnormal respiratory motile cilium morphology (HP:0005938)2.24166501
106Choanal stenosis (HP:0000452)2.23801046
107Tubular atrophy (HP:0000092)2.23752789
108Basal cell carcinoma (HP:0002671)2.19594291
109Popliteal pterygium (HP:0009756)2.19107113
110Febrile seizures (HP:0002373)2.18678119
111Optic disc pallor (HP:0000543)2.18655285
112Occipital encephalocele (HP:0002085)2.17791824
113Premature skin wrinkling (HP:0100678)2.17392090
114Pendular nystagmus (HP:0012043)2.16718115
115Inability to walk (HP:0002540)2.16470657
116Bile duct proliferation (HP:0001408)2.16232317
117Abnormal biliary tract physiology (HP:0012439)2.16232317
118Squamous cell carcinoma (HP:0002860)2.15839012
119Aplasia/Hypoplasia of the tongue (HP:0010295)2.15623683
120Dysostosis multiplex (HP:0000943)2.13965503
121Decreased central vision (HP:0007663)2.13762043
122Polydipsia (HP:0001959)2.13059966
123Abnormal drinking behavior (HP:0030082)2.13059966
124Median cleft lip (HP:0000161)2.10071794
125Hemiparesis (HP:0001269)2.09727501
126Keratoconus (HP:0000563)2.09485037
127Increased corneal curvature (HP:0100692)2.09485037
128Chronic hepatic failure (HP:0100626)2.09243337
129Broad-based gait (HP:0002136)2.09070130
130Increased serum lactate (HP:0002151)2.08893857
131Dysautonomia (HP:0002459)2.07934711
132Abnormality of the labia minora (HP:0012880)2.07488165
133Abnormal ciliary motility (HP:0012262)2.07397108
134Small hand (HP:0200055)2.07179786
135Progressive sensorineural hearing impairment (HP:0000408)2.06560642
136Ectopic anus (HP:0004397)2.06197775
137Male pseudohermaphroditism (HP:0000037)2.05596645
138Hypoplasia of the radius (HP:0002984)2.05518836
139Abnormality of the ileum (HP:0001549)2.05474550
140Redundant skin (HP:0001582)2.05315631
141Progressive microcephaly (HP:0000253)2.04894859
142Abolished electroretinogram (ERG) (HP:0000550)2.04650006
143Cerebral aneurysm (HP:0004944)2.03565611
144Joint stiffness (HP:0001387)2.03516192
145Renal cortical cysts (HP:0000803)2.03473393
146Aplasia/Hypoplasia of the tibia (HP:0005772)2.01736480
147Dynein arm defect of respiratory motile cilia (HP:0012255)2.01477915
148Absent/shortened dynein arms (HP:0200106)2.01477915
149Tachypnea (HP:0002789)2.00627661
150Obstructive sleep apnea (HP:0002870)2.00420613
151Poor coordination (HP:0002370)1.99194560
152Anophthalmia (HP:0000528)1.98783375
153Capillary hemangiomas (HP:0005306)1.96155847
154Postaxial foot polydactyly (HP:0001830)1.95891630
155Bulbar palsy (HP:0001283)1.95558731
156Failure to thrive in infancy (HP:0001531)1.95146657
157Hypercortisolism (HP:0001578)1.93309691
158Cheilitis (HP:0100825)1.93295945
159Drooling (HP:0002307)1.93048009
160Microretrognathia (HP:0000308)1.90674770
161Hyperglycinemia (HP:0002154)1.90252925
162Lipid accumulation in hepatocytes (HP:0006561)1.90049848
163Vertebral fusion (HP:0002948)1.89174374
164Progressive inability to walk (HP:0002505)1.87965054
165Methylmalonic acidemia (HP:0002912)1.87837817
166Lactic acidosis (HP:0003128)1.87329072
167Postaxial hand polydactyly (HP:0001162)1.86697022
168Methylmalonic aciduria (HP:0012120)1.86520132
169Selective tooth agenesis (HP:0001592)1.86441651
170Cerebral edema (HP:0002181)1.85875834
171Aganglionic megacolon (HP:0002251)1.84562725
172Amelogenesis imperfecta (HP:0000705)1.83919613
173Split hand (HP:0001171)1.83750147
1743-Methylglutaconic aciduria (HP:0003535)1.83200450
175Diaphragmatic weakness (HP:0009113)1.82447439
176Delayed CNS myelination (HP:0002188)1.81544919
177Abnormal number of incisors (HP:0011064)1.81076905
178Abnormal rod and cone electroretinograms (HP:0008323)1.79264147
179Short thumb (HP:0009778)1.78618907
180Agitation (HP:0000713)1.78510056
181Short 5th finger (HP:0009237)1.78502906
182Hypoplasia of the ulna (HP:0003022)1.78363713
183Preaxial hand polydactyly (HP:0001177)1.77567808
184Polyuria (HP:0000103)1.77336119
185Thickened helices (HP:0000391)1.77080660
186Opisthotonus (HP:0002179)1.76451374
187Bowing of the arm (HP:0006488)1.76385429
188Bowed forearm bones (HP:0003956)1.76385429
189Optic nerve hypoplasia (HP:0000609)1.76361958
190Diminished movement (HP:0002374)1.76360546
191Progressive cerebellar ataxia (HP:0002073)1.76276246
192Abnormal respiratory motile cilium physiology (HP:0012261)1.75927311
193Oligodactyly (hands) (HP:0001180)1.74834490
194Lethargy (HP:0001254)1.74711568
195Hypotrichosis (HP:0001006)1.73843291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.48980014
2MAPK155.06405799
3DDR24.77655071
4MAP3K64.02410686
5PINK13.69231491
6TRIM283.54393950
7BCKDK3.09918347
8FRK3.00952047
9ADRBK22.89184498
10UHMK12.82512964
11PRKD22.80504363
12MAP4K22.74078839
13TYRO32.72431245
14MATK2.67934068
15CASK2.53460999
16MAP3K112.51731459
17DAPK12.47058246
18VRK22.44142028
19BMPR1B2.44083315
20YES12.41740692
21FGR2.41024978
22NUAK12.22650640
23WNK32.15095513
24DYRK1B2.02548891
25PDGFRA2.00838511
26GRK11.95928816
27BMX1.93974268
28AKT31.83399836
29PIM21.79558833
30MAP3K101.68222113
31CSK1.65582196
32WNK41.58525542
33CSNK1G31.50169245
34DAPK21.46475453
35CSNK1G21.43989375
36CDK71.41499085
37LIMK11.39623296
38CSNK1A1L1.38930682
39NME11.38664813
40ERBB31.37972426
41TAOK31.35039255
42BCR1.31886838
43STK161.30831529
44CDK191.29919753
45PDK21.29784192
46PHKG21.27253225
47PHKG11.27253225
48HIPK21.26907637
49TRPM71.26288033
50CDC42BPA1.25906299
51VRK11.23057461
52LATS21.22939295
53RPS6KC11.22912485
54RPS6KL11.22912485
55ADRBK11.19774702
56ACVR1B1.18149376
57PRPF4B1.14319158
58PKN11.12011623
59PIM11.08573495
60RPS6KA61.07458434
61TESK21.06834228
62MAP3K91.02669293
63PAK30.99070519
64CHEK20.97899701
65PRKCG0.95883606
66PRKD30.95638172
67PRKCE0.94657162
68MAPK110.93543747
69DYRK30.91374676
70CDK60.88654357
71PRKCI0.85221181
72NTRK20.85100593
73ATR0.85029062
74ABL20.84015647
75OXSR10.83548499
76MUSK0.82910272
77EPHA30.80876065
78PTK2B0.79636425
79PLK20.77727170
80TAOK20.77180187
81GSK3A0.73963858
82PRKAA10.73891024
83MAP2K40.71525602
84CCNB10.71066950
85RPS6KA50.70457181
86PAK60.69132833
87EPHB20.65088903
88MAPKAPK30.64273347
89TLK10.63696469
90RPS6KA10.63163649
91PLK10.62732670
92SIK30.62270320
93NTRK30.61895213
94MARK10.61715034
95MARK20.61598163
96CDK80.61132697
97TNIK0.60466446
98MTOR0.60436578
99DYRK1A0.60047921
100PIK3CA0.58812726
101GRK70.57318249
102MINK10.56792213
103CSNK1A10.56515808
104CAMK10.55386302
105RPS6KB10.52605927
106SIK20.51997777
107WEE10.51778234
108NEK20.51145030
109CDK20.50900438
110GRK50.50426822
111FLT30.50269521
112MAP2K60.49841464
113PRKACA0.48978741
114EPHA40.47336102
115SRPK10.47211868
116TESK10.47054365
117CAMKK20.47015151
118STK390.45628072
119MAPKAPK50.45370668
120STK380.44638952
121RAF10.44469736
122TNK20.44433279
123PNCK0.40314129
124DYRK20.40092684
125KDR0.40007214
126DMPK0.39065879
127MAPK100.39002113
128PRKCZ0.37811007
129MAPK140.37626913
130MAPK10.37083377
131LYN0.35662686
132CAMK2D0.34619925
133CAMK2B0.34416590
134ALK0.33924535
135SGK10.33520508
136MAPK30.33043465
137MAPK90.32634029
138PLK40.32619260
139CDK11A0.32336068
140ZAK0.32292698
141INSRR0.31997953
142MAP2K70.31875986
143PDGFRB0.30420095
144MAP3K70.29705352
145CSNK2A10.29413980
146CSNK1G10.29286256
147CAMK2G0.27156271
148GSK3B0.27003438
149CAMK2A0.26932644
150MAPK130.26557507
151CDK120.26480303
152ATM0.26367030
153CDK10.25887679
154CDK180.24871696
155CHEK10.24392555
156CDK150.24204138
157CHUK0.23305828
158AKT10.23121485
159MAP3K40.21869349
160CDK50.21790945
161PRKDC0.19638098
162PRKAA20.19164762
163EGFR0.19110605
164BRSK10.19044180

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034104.13284430
2Mismatch repair_Homo sapiens_hsa034304.11101412
3Fatty acid biosynthesis_Homo sapiens_hsa000614.05076085
4DNA replication_Homo sapiens_hsa030303.02681810
5Oxidative phosphorylation_Homo sapiens_hsa001902.94312700
6Parkinsons disease_Homo sapiens_hsa050122.43079172
7Hedgehog signaling pathway_Homo sapiens_hsa043402.37132172
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.30258346
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.24741303
10Notch signaling pathway_Homo sapiens_hsa043302.23818647
11Circadian rhythm_Homo sapiens_hsa047102.23393533
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21288850
13Butanoate metabolism_Homo sapiens_hsa006502.18306420
14mRNA surveillance pathway_Homo sapiens_hsa030152.13064319
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.08325151
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99165794
17Hippo signaling pathway_Homo sapiens_hsa043901.98121791
18Fanconi anemia pathway_Homo sapiens_hsa034601.93918849
19RNA polymerase_Homo sapiens_hsa030201.88139060
20Basal cell carcinoma_Homo sapiens_hsa052171.87610211
21Huntingtons disease_Homo sapiens_hsa050161.82516623
22Homologous recombination_Homo sapiens_hsa034401.79338405
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69476011
24Wnt signaling pathway_Homo sapiens_hsa043101.65798650
25Protein export_Homo sapiens_hsa030601.64630817
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61488449
27Peroxisome_Homo sapiens_hsa041461.61041662
28Nucleotide excision repair_Homo sapiens_hsa034201.60405023
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59833791
30Linoleic acid metabolism_Homo sapiens_hsa005911.58087893
31Spliceosome_Homo sapiens_hsa030401.58021500
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53524709
33Alzheimers disease_Homo sapiens_hsa050101.51663057
34mTOR signaling pathway_Homo sapiens_hsa041501.50682982
35Cardiac muscle contraction_Homo sapiens_hsa042601.48861863
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48650029
37Propanoate metabolism_Homo sapiens_hsa006401.42455294
38Longevity regulating pathway - mammal_Homo sapiens_hsa042111.42112002
39Tryptophan metabolism_Homo sapiens_hsa003801.38498691
40Adherens junction_Homo sapiens_hsa045201.35560104
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33441528
42Nitrogen metabolism_Homo sapiens_hsa009101.32878619
43Selenocompound metabolism_Homo sapiens_hsa004501.31020793
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29671945
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28177382
46p53 signaling pathway_Homo sapiens_hsa041151.25236989
47Collecting duct acid secretion_Homo sapiens_hsa049661.20941764
48RNA transport_Homo sapiens_hsa030131.14891792
49Ether lipid metabolism_Homo sapiens_hsa005651.14663493
50beta-Alanine metabolism_Homo sapiens_hsa004101.14313779
51Cell cycle_Homo sapiens_hsa041101.11606078
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09237489
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08988685
54Colorectal cancer_Homo sapiens_hsa052101.07602045
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.07308529
56Bladder cancer_Homo sapiens_hsa052191.06695329
57TGF-beta signaling pathway_Homo sapiens_hsa043501.06040741
58Lysine degradation_Homo sapiens_hsa003101.05182551
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05151445
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04200529
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03854290
62Regulation of autophagy_Homo sapiens_hsa041401.03759328
63Chemical carcinogenesis_Homo sapiens_hsa052041.02894959
64Primary immunodeficiency_Homo sapiens_hsa053401.02341221
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02264771
66ErbB signaling pathway_Homo sapiens_hsa040121.01419605
67Oocyte meiosis_Homo sapiens_hsa041141.00530240
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.99027681
69Olfactory transduction_Homo sapiens_hsa047400.98241768
70Shigellosis_Homo sapiens_hsa051310.98156790
71Pyrimidine metabolism_Homo sapiens_hsa002400.97623994
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97420591
73Nicotine addiction_Homo sapiens_hsa050330.96616921
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96283912
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95382212
76Caffeine metabolism_Homo sapiens_hsa002320.94335676
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.94137651
78Chronic myeloid leukemia_Homo sapiens_hsa052200.93816371
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.92633475
80Sulfur relay system_Homo sapiens_hsa041220.92145847
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90569080
82Metabolic pathways_Homo sapiens_hsa011000.89921683
83VEGF signaling pathway_Homo sapiens_hsa043700.87863945
84Steroid biosynthesis_Homo sapiens_hsa001000.87722862
85Fatty acid elongation_Homo sapiens_hsa000620.87113864
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86352571
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83968475
88ABC transporters_Homo sapiens_hsa020100.83872554
89Purine metabolism_Homo sapiens_hsa002300.83468038
90Choline metabolism in cancer_Homo sapiens_hsa052310.83008983
91Proteasome_Homo sapiens_hsa030500.81896255
92Glutamatergic synapse_Homo sapiens_hsa047240.80340772
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.79609453
94Gap junction_Homo sapiens_hsa045400.78527023
95Arginine and proline metabolism_Homo sapiens_hsa003300.77588552
96MicroRNAs in cancer_Homo sapiens_hsa052060.76290795
97MAPK signaling pathway_Homo sapiens_hsa040100.74437490
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73672722
99Arachidonic acid metabolism_Homo sapiens_hsa005900.73584816
100Endometrial cancer_Homo sapiens_hsa052130.73428998
101Melanogenesis_Homo sapiens_hsa049160.72158113
102Amphetamine addiction_Homo sapiens_hsa050310.72129474
103Fructose and mannose metabolism_Homo sapiens_hsa000510.69238945
104Retinol metabolism_Homo sapiens_hsa008300.68530269
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.68315022
106Insulin secretion_Homo sapiens_hsa049110.66897424
107Dorso-ventral axis formation_Homo sapiens_hsa043200.66894635
108Acute myeloid leukemia_Homo sapiens_hsa052210.66526980
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65085811
110Ovarian steroidogenesis_Homo sapiens_hsa049130.64583147
111Glutathione metabolism_Homo sapiens_hsa004800.64446332
112N-Glycan biosynthesis_Homo sapiens_hsa005100.61754938
113Histidine metabolism_Homo sapiens_hsa003400.60871013
114GABAergic synapse_Homo sapiens_hsa047270.60753875
115Insulin signaling pathway_Homo sapiens_hsa049100.60426068
116Serotonergic synapse_Homo sapiens_hsa047260.58891296
117HTLV-I infection_Homo sapiens_hsa051660.58075198
118Thyroid cancer_Homo sapiens_hsa052160.57104001
119Folate biosynthesis_Homo sapiens_hsa007900.56916338
120Fatty acid metabolism_Homo sapiens_hsa012120.55141711
121Dopaminergic synapse_Homo sapiens_hsa047280.54603459
122Salivary secretion_Homo sapiens_hsa049700.54304540
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53760771
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53146523
125Calcium signaling pathway_Homo sapiens_hsa040200.52236264
126Ribosome_Homo sapiens_hsa030100.51725189
127Synaptic vesicle cycle_Homo sapiens_hsa047210.51230128
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51094554
129GnRH signaling pathway_Homo sapiens_hsa049120.50681676
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50421667
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50360187
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49597154
133Axon guidance_Homo sapiens_hsa043600.49273860
134Tyrosine metabolism_Homo sapiens_hsa003500.48833146
135Morphine addiction_Homo sapiens_hsa050320.48474632
136Tight junction_Homo sapiens_hsa045300.47504769
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46786221
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46684494
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46048040
140Fatty acid degradation_Homo sapiens_hsa000710.46009263
141Sulfur metabolism_Homo sapiens_hsa009200.43825185
142AMPK signaling pathway_Homo sapiens_hsa041520.42546633
143Herpes simplex infection_Homo sapiens_hsa051680.41798082
144Hepatitis B_Homo sapiens_hsa051610.40803106
145Estrogen signaling pathway_Homo sapiens_hsa049150.39663173
146Galactose metabolism_Homo sapiens_hsa000520.39441885
147Pathways in cancer_Homo sapiens_hsa052000.38876159
148RNA degradation_Homo sapiens_hsa030180.38252110
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37715272
150Basal transcription factors_Homo sapiens_hsa030220.37625645
151Phototransduction_Homo sapiens_hsa047440.37272284
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.36243078
153Viral carcinogenesis_Homo sapiens_hsa052030.35378420
154Endocytosis_Homo sapiens_hsa041440.35025605
155Viral myocarditis_Homo sapiens_hsa054160.34277871
156Proteoglycans in cancer_Homo sapiens_hsa052050.33931020
157Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33799000
158Prolactin signaling pathway_Homo sapiens_hsa049170.33627209
159Mineral absorption_Homo sapiens_hsa049780.33558597
160B cell receptor signaling pathway_Homo sapiens_hsa046620.33445949
161Circadian entrainment_Homo sapiens_hsa047130.33170105
162Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33027766
163Cocaine addiction_Homo sapiens_hsa050300.32898413
164Central carbon metabolism in cancer_Homo sapiens_hsa052300.31414090
165Taste transduction_Homo sapiens_hsa047420.31227565
166PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31032132
167Pancreatic cancer_Homo sapiens_hsa052120.30617504
168Small cell lung cancer_Homo sapiens_hsa052220.29993198

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