ENG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.13504949
2vascular endothelial growth factor signaling pathway (GO:0038084)6.10249690
3endothelium development (GO:0003158)5.08797303
4blood vessel maturation (GO:0001955)5.08256405
5cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.95570798
6surfactant homeostasis (GO:0043129)4.82243286
7barbed-end actin filament capping (GO:0051016)4.70830846
8lymphangiogenesis (GO:0001946)4.65214542
9morphogenesis of an endothelium (GO:0003159)4.37813494
10endothelial tube morphogenesis (GO:0061154)4.37813494
11positive regulation of vasculogenesis (GO:2001214)4.34847687
12retina vasculature morphogenesis in camera-type eye (GO:0061299)4.14851983
13regulation of mononuclear cell migration (GO:0071675)4.11604710
14regulation of endothelial cell differentiation (GO:0045601)4.01062048
15virion attachment to host cell (GO:0019062)3.99323066
16adhesion of symbiont to host cell (GO:0044650)3.99323066
17basement membrane organization (GO:0071711)3.94418629
18heart trabecula formation (GO:0060347)3.90171313
19apoptotic cell clearance (GO:0043277)3.89833898
20regulation of macrophage chemotaxis (GO:0010758)3.76766674
21cellular response to thyroid hormone stimulus (GO:0097067)3.75784159
22glomerular filtration (GO:0003094)3.69813624
23renal filtration (GO:0097205)3.66506884
24vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.66357496
25regulation of vasculogenesis (GO:2001212)3.63874646
26hyaluronan catabolic process (GO:0030214)3.63341129
27blood vessel endothelial cell migration (GO:0043534)3.62262735
28negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.54396633
29endothelial cell morphogenesis (GO:0001886)3.51259728
30cell migration involved in sprouting angiogenesis (GO:0002042)3.47770061
31chemical homeostasis within a tissue (GO:0048875)3.47316783
32protein localization to endosome (GO:0036010)3.46755413
33lysine catabolic process (GO:0006554)3.42905080
34lysine metabolic process (GO:0006553)3.42905080
35endodermal cell differentiation (GO:0035987)3.38365476
36cardiac myofibril assembly (GO:0055003)3.33265682
37fatty acid transmembrane transport (GO:1902001)3.32248958
38pinocytosis (GO:0006907)3.32055805
39glomerular basement membrane development (GO:0032836)3.30846717
40endothelial cell chemotaxis (GO:0035767)3.30125858
41positive regulation of receptor recycling (GO:0001921)3.29866281
42bundle of His cell to Purkinje myocyte communication (GO:0086069)3.28498522
43positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.27157794
44glomerular visceral epithelial cell development (GO:0072015)3.24211689
45stress fiber assembly (GO:0043149)3.24208630
46glycosphingolipid catabolic process (GO:0046479)3.23513617
47negative regulation of interleukin-12 production (GO:0032695)3.23195383
48substrate-dependent cell migration (GO:0006929)3.22509667
49keratan sulfate catabolic process (GO:0042340)3.17830551
50mannose metabolic process (GO:0006013)3.17191199
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16620432
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16620432
53sarcomere organization (GO:0045214)3.15997175
542-oxoglutarate metabolic process (GO:0006103)3.13210866
55negative regulation of blood vessel endothelial cell migration (GO:0043537)3.12908314
56negative regulation of nitric oxide biosynthetic process (GO:0045019)3.10789331
57fatty acid beta-oxidation (GO:0006635)3.10524306
58peptidyl-tyrosine autophosphorylation (GO:0038083)3.10482274
59transcytosis (GO:0045056)3.10230534
60negative regulation of endothelial cell apoptotic process (GO:2000352)3.09892158
61carnitine shuttle (GO:0006853)3.08648552
62negative regulation of erythrocyte differentiation (GO:0045647)3.06633805
63regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.06022841
64response to thyroid hormone (GO:0097066)3.05834024
65response to magnesium ion (GO:0032026)3.05752711
66negative regulation of fibrinolysis (GO:0051918)3.01030689
67valine metabolic process (GO:0006573)3.00590365
68sprouting angiogenesis (GO:0002040)2.98272813
69ovulation from ovarian follicle (GO:0001542)2.97933522
70positive regulation of endothelial cell differentiation (GO:0045603)2.96074756
71amino sugar catabolic process (GO:0046348)2.94518546
72wound healing, spreading of epidermal cells (GO:0035313)2.93802920
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.93782503
74response to mercury ion (GO:0046689)2.91688188
75negative regulation of focal adhesion assembly (GO:0051895)2.89991024
76negative regulation of cell junction assembly (GO:1901889)2.89991024
77negative regulation of adherens junction organization (GO:1903392)2.89991024
78endothelial cell differentiation (GO:0045446)2.89738200
79fibril organization (GO:0097435)2.89437308
80regulation of early endosome to late endosome transport (GO:2000641)2.89305541
81coronary vasculature morphogenesis (GO:0060977)2.88605886
82response to peptidoglycan (GO:0032494)2.88520369
83protein heterotrimerization (GO:0070208)2.88204448
84glycolipid catabolic process (GO:0019377)2.87395066
85positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.86826219
86extracellular fibril organization (GO:0043206)2.85885053
87definitive hemopoiesis (GO:0060216)2.84871795
88tricarboxylic acid metabolic process (GO:0072350)2.83281482
89negative regulation of endothelial cell migration (GO:0010596)2.81133423
90glomerular epithelial cell development (GO:0072310)2.80755056
91regulation of membrane protein ectodomain proteolysis (GO:0051043)2.80139367
92negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.79433235
93regulation of monocyte chemotaxis (GO:0090025)2.79273313
94fatty acid oxidation (GO:0019395)2.78711982
95positive regulation of extracellular matrix organization (GO:1903055)2.78469921
96negative regulation of smooth muscle cell migration (GO:0014912)2.77601126
97glial cell migration (GO:0008347)2.77083283
98glyoxylate metabolic process (GO:0046487)2.75916806
99negative regulation of platelet activation (GO:0010544)2.75702022
100skin morphogenesis (GO:0043589)2.75245095
101ethanol oxidation (GO:0006069)2.74708351
102establishment of endothelial barrier (GO:0061028)2.73113531
103myofibril assembly (GO:0030239)2.72376112
104* patterning of blood vessels (GO:0001569)2.71894154
105* vasculogenesis (GO:0001570)2.70335219
106adenosine receptor signaling pathway (GO:0001973)2.70259093
107lipid oxidation (GO:0034440)2.70045889
108oxaloacetate metabolic process (GO:0006107)2.69959100
109angiogenesis involved in wound healing (GO:0060055)2.69125204
110collagen metabolic process (GO:0032963)2.67417249
111positive regulation of monocyte chemotaxis (GO:0090026)2.66366746
112lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66171962
113protein carboxylation (GO:0018214)2.65906815
114peptidyl-glutamic acid carboxylation (GO:0017187)2.65906815
115fatty acid catabolic process (GO:0009062)2.65060491
116cell adhesion mediated by integrin (GO:0033627)2.64745425
117collagen catabolic process (GO:0030574)2.63691160
118complement activation, alternative pathway (GO:0006957)2.63514304
119plasma membrane repair (GO:0001778)2.63076565
120alpha-linolenic acid metabolic process (GO:0036109)2.62522726
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61957436
122endothelial cell migration (GO:0043542)2.61830682
123regulation of cholesterol storage (GO:0010885)2.60368224
124peptide catabolic process (GO:0043171)2.59512340
125response to interferon-alpha (GO:0035455)2.58771501
126adhesion of symbiont to host (GO:0044406)2.58390279
127regulation of protein activation cascade (GO:2000257)2.58241696
128regulation of complement activation (GO:0030449)2.57055952
129positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57007903
130regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.56971373
131positive regulation of focal adhesion assembly (GO:0051894)2.56865369
132positive regulation of cell junction assembly (GO:1901890)2.56865369
133blood coagulation, intrinsic pathway (GO:0007597)2.54557310
134low-density lipoprotein particle clearance (GO:0034383)2.53751866
135oligosaccharide catabolic process (GO:0009313)2.52811263
136ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.52667909
137regulation of fatty acid oxidation (GO:0046320)2.52571304
138tricarboxylic acid cycle (GO:0006099)2.52485515
139positive regulation of smooth muscle cell migration (GO:0014911)2.51909308
140regulation of blood vessel endothelial cell migration (GO:0043535)2.51541526
141regulation of p38MAPK cascade (GO:1900744)2.51520769
142embryonic heart tube development (GO:0035050)2.50788180
143tooth mineralization (GO:0034505)2.50265716
144decidualization (GO:0046697)2.50030500
145regulation of endothelial cell apoptotic process (GO:2000351)2.49399322
146carnitine metabolic process (GO:0009437)2.48538045
147negative regulation of vascular permeability (GO:0043116)2.47724781
148trabecula formation (GO:0060343)2.47652421
149regulation of fibrinolysis (GO:0051917)2.47173998
150positive regulation of endothelial cell apoptotic process (GO:2000353)2.47102291
151regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47028677
152ceramide catabolic process (GO:0046514)2.47022230
153amino-acid betaine metabolic process (GO:0006577)2.46971177
154regulation of vascular permeability (GO:0043114)2.46826842
155multicellular organismal macromolecule metabolic process (GO:0044259)2.46202666
156erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.45798710
157L-phenylalanine metabolic process (GO:0006558)2.45798710
158multicellular organismal catabolic process (GO:0044243)2.44362845
159regulation of extracellular matrix disassembly (GO:0010715)2.43722058
160positive regulation of chemokine biosynthetic process (GO:0045080)2.43154567
161detection of molecule of bacterial origin (GO:0032490)2.41647895
162response to laminar fluid shear stress (GO:0034616)2.40329541
163negative regulation of granulocyte differentiation (GO:0030853)2.39029693
164chondrocyte proliferation (GO:0035988)2.38940897
165regulation of mast cell degranulation (GO:0043304)2.38795233
166N-acetylneuraminate metabolic process (GO:0006054)2.37881033
167dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37873706
168membrane lipid catabolic process (GO:0046466)2.37796355
169embryo implantation (GO:0007566)2.37794482
170cortical actin cytoskeleton organization (GO:0030866)2.37744751
171response to progesterone (GO:0032570)2.36206336
172semaphorin-plexin signaling pathway (GO:0071526)2.34946476
173* extracellular matrix disassembly (GO:0022617)2.34677802
174regulation of leukocyte degranulation (GO:0043300)2.33946356
175monocyte chemotaxis (GO:0002548)2.33858088
176multicellular organismal metabolic process (GO:0044236)2.31393630
177neutrophil activation involved in immune response (GO:0002283)2.30768851
178regulation of integrin-mediated signaling pathway (GO:2001044)2.30461845
179positive regulation of odontogenesis (GO:0042482)2.30118771
180regulation of dendritic cell antigen processing and presentation (GO:0002604)2.29351474
181regulation of macrophage cytokine production (GO:0010935)2.29346573
182regulation of smooth muscle cell migration (GO:0014910)2.27247475
183macrophage activation involved in immune response (GO:0002281)2.27130895
184sphingolipid catabolic process (GO:0030149)2.25476347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.95251733
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.23760976
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.33534039
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.62494234
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.27545851
6CLOCK_20551151_ChIP-Seq_293T_Human3.04165362
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.01256195
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.91489462
9* GATA2_21666600_ChIP-Seq_HMVEC_Human2.84395076
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64529134
11GATA1_22025678_ChIP-Seq_K562_Human2.63308045
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.58187102
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49239655
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.45166612
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.41826693
16SCL_19346495_ChIP-Seq_HPC-7_Human2.29250702
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15556603
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.05330032
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03283686
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.01232987
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99297247
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97615499
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94612461
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90680191
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.89210062
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87944181
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85243994
28TBX20_22328084_ChIP-Seq_HEART_Mouse1.84180003
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.84180003
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.77322211
31* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75451088
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.75420427
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.70852104
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69709086
35* LXR_22292898_ChIP-Seq_THP-1_Human1.69519698
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.68263140
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67089289
38GATA1_19941826_ChIP-Seq_K562_Human1.66528857
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64906376
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60423808
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.55714788
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50073674
43KDM2B_26808549_Chip-Seq_K562_Human1.46663303
44TCF7_22412390_ChIP-Seq_EML_Mouse1.45891489
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.44723171
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38411869
47VDR_21846776_ChIP-Seq_THP-1_Human1.38245696
48* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34996838
49VDR_24787735_ChIP-Seq_THP-1_Human1.34630815
50* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34310551
51RACK7_27058665_Chip-Seq_MCF-7_Human1.33688606
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33046131
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32802363
54SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31457239
55MAF_26560356_Chip-Seq_TH1_Human1.30952221
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.30720731
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30661579
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29840496
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29036737
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28944942
61KDM2B_26808549_Chip-Seq_DND41_Human1.28472829
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27102669
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26463685
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26417184
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25198376
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.25046412
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24604434
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24027672
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22521775
70* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21937646
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21753965
72SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21097023
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20847264
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18713820
75* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18306390
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16839770
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16319016
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14947078
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14591310
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14304621
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12793969
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11829770
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10747295
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10216329
85NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09901726
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09736310
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09551452
88TP53_22127205_ChIP-Seq_IMR90_Human1.09270353
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08607711
90* MYC_22102868_ChIP-Seq_BL_Human1.08104370
91* GATA2_19941826_ChIP-Seq_K562_Human1.07637761
92* NCOR1_26117541_ChIP-Seq_K562_Human1.07495405
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06993846
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05228053
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03442407
96* SPI1_23127762_ChIP-Seq_K562_Human1.03348514
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.03022933
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.02548709
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01803167
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.00990131
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00760061
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00713364
103* ZNF263_19887448_ChIP-Seq_K562_Human1.00032000
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99617608
105KDM2B_26808549_Chip-Seq_JURKAT_Human0.99230839
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98508289
107EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98439274
108RUNX_20019798_ChIP-Seq_JUKART_Human0.98378523
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98340967
110* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98051961
111UTX_26944678_Chip-Seq_JUKART_Human0.96585057
112* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96263747
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.95688916
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95286600
115CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94446891
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93436736
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92707737
118SA1_27219007_Chip-Seq_ERYTHROID_Human0.92567118
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92521077
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92185995
121ATF3_27146783_Chip-Seq_COLON_Human0.91764998
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91103014
123* BCL6_27268052_Chip-Seq_Bcells_Human0.90555191
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90006740
125* VDR_24763502_ChIP-Seq_THP-1_Human0.89551252
126* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89449449
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88670650
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88664524
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87958661
130MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86943480
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86778187
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86700904
133ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83980048
134CTCF_21964334_Chip-Seq_Bcells_Human0.83751793
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83096713
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.82514328
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82295921
138GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82073279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.29617699
2MP0001879_abnormal_lymphatic_vessel4.36172466
3MP0005058_abnormal_lysosome_morphology4.03258973
4MP0004084_abnormal_cardiac_muscle3.38666734
5MP0005167_abnormal_blood-brain_barrier3.18618539
6MP0004272_abnormal_basement_membrane3.03525844
7MP0003724_increased_susceptibility_to3.02463322
8MP0003828_pulmonary_edema2.63818618
9MP0006054_spinal_hemorrhage2.33966080
10MP0004036_abnormal_muscle_relaxation2.20248532
11MP0003172_abnormal_lysosome_physiology2.16731481
12MP0004215_abnormal_myocardial_fiber2.07671615
13MP0003436_decreased_susceptibility_to2.07600074
14MP0005360_urolithiasis2.06873236
15MP0006082_CNS_inflammation2.04635410
16MP0002837_dystrophic_cardiac_calcinosis2.03417244
17MP0000751_myopathy2.02861776
18MP0005503_abnormal_tendon_morphology2.00933396
19MP0003279_aneurysm1.97410566
20MP0002139_abnormal_hepatobiliary_system1.95767557
21MP0006138_congestive_heart_failure1.93206619
22MP0005257_abnormal_intraocular_pressure1.86211021
23MP0005330_cardiomyopathy1.85261064
24MP0002998_abnormal_bone_remodeling1.85253039
25MP0002138_abnormal_hepatobiliary_system1.81144370
26MP0005085_abnormal_gallbladder_physiolo1.80792436
27MP0001533_abnormal_skeleton_physiology1.77810054
28MP0004130_abnormal_muscle_cell1.75475119
29MP0003091_abnormal_cell_migration1.75170496
30MP0008775_abnormal_heart_ventricle1.74918470
31MP0003705_abnormal_hypodermis_morpholog1.74675525
32MP0005365_abnormal_bile_salt1.74435829
33MP0000343_altered_response_to1.73939789
34MP0005385_cardiovascular_system_phenoty1.73834588
35MP0001544_abnormal_cardiovascular_syste1.73834588
36MP0001542_abnormal_bone_strength1.71965697
37MP0003191_abnormal_cellular_cholesterol1.71376798
38MP0001958_emphysema1.70592041
39MP0008438_abnormal_cutaneous_collagen1.70429021
40MP0000604_amyloidosis1.66830878
41MP0002877_abnormal_melanocyte_morpholog1.65955742
42MP0002148_abnormal_hypersensitivity_rea1.63921038
43MP0002933_joint_inflammation1.62554793
44MP0003566_abnormal_cell_adhesion1.61185666
45MP0002419_abnormal_innate_immunity1.61135972
46MP0010630_abnormal_cardiac_muscle1.56855337
47MP0008875_abnormal_xenobiotic_pharmacok1.56508030
48MP0003448_altered_tumor_morphology1.49473746
49MP0000749_muscle_degeneration1.43519882
50* MP0000767_abnormal_smooth_muscle1.43479693
51MP0005670_abnormal_white_adipose1.42531663
52MP0004147_increased_porphyrin_level1.40485011
53MP0005165_increased_susceptibility_to1.40236628
54MP0003252_abnormal_bile_duct1.39506820
55MP0009785_altered_susceptibility_to1.38994679
56MP0002972_abnormal_cardiac_muscle1.37224866
57MP0000249_abnormal_blood_vessel1.36991388
58MP0001849_ear_inflammation1.34199416
59MP0010329_abnormal_lipoprotein_level1.31060851
60MP0005390_skeleton_phenotype1.28457673
61* MP0002128_abnormal_blood_circulation1.28259699
62MP0003300_gastrointestinal_ulcer1.27977888
63MP0000858_altered_metastatic_potential1.27603675
64MP0003646_muscle_fatigue1.27079316
65MP0000750_abnormal_muscle_regeneration1.26291386
66MP0005000_abnormal_immune_tolerance1.23413428
67MP0005025_abnormal_response_to1.23013155
68MP0009840_abnormal_foam_cell1.22310662
69MP0004087_abnormal_muscle_fiber1.20586566
70MP0005319_abnormal_enzyme/_coenzyme1.19274171
71MP0002896_abnormal_bone_mineralization1.19198606
72MP0005397_hematopoietic_system_phenotyp1.18484954
73MP0001545_abnormal_hematopoietic_system1.18484954
74MP0009278_abnormal_bone_marrow1.17833770
75MP0001853_heart_inflammation1.17192823
76MP0005387_immune_system_phenotype1.15084673
77MP0001790_abnormal_immune_system1.15084673
78MP0009643_abnormal_urine_homeostasis1.14269933
79MP0000465_gastrointestinal_hemorrhage1.12991407
80MP0003806_abnormal_nucleotide_metabolis1.12147096
81MP0005508_abnormal_skeleton_morphology1.11913510
82MP0004484_altered_response_of1.11207999
83MP0003329_amyloid_beta_deposits1.11005420
84MP0005451_abnormal_body_composition1.09148768
85MP0004808_abnormal_hematopoietic_stem1.08468840
86MP0001835_abnormal_antigen_presentation1.06679462
87MP0005332_abnormal_amino_acid1.05501668
88MP0004858_abnormal_nervous_system1.05215189
89MP0005620_abnormal_muscle_contractility1.05020397
90MP0000013_abnormal_adipose_tissue1.04165349
91MP0005166_decreased_susceptibility_to1.03712285
92MP0002127_abnormal_cardiovascular_syste1.03061318
93MP0004510_myositis1.02787497
94* MP0001614_abnormal_blood_vessel1.02591532
95MP0002332_abnormal_exercise_endurance1.02391437
96MP0005666_abnormal_adipose_tissue1.01579443
97MP0000230_abnormal_systemic_arterial1.00532756
98MP0008260_abnormal_autophagy0.98617189
99MP0003950_abnormal_plasma_membrane0.98213838
100MP0003795_abnormal_bone_structure0.98114553
101MP0003453_abnormal_keratinocyte_physiol0.97242670
102MP0003303_peritoneal_inflammation0.96975988
103MP0003690_abnormal_glial_cell0.96230219
104MP0005275_abnormal_skin_tensile0.94452481
105MP0005409_darkened_coat_color0.94355501
106* MP0002925_abnormal_cardiovascular_devel0.91924557
107* MP0000266_abnormal_heart_morphology0.91886549
108MP0009384_cardiac_valve_regurgitation0.91833234
109MP0000609_abnormal_liver_physiology0.91805418
110MP0002254_reproductive_system_inflammat0.91044030
111* MP0005595_abnormal_vascular_smooth0.90913595
112MP0002396_abnormal_hematopoietic_system0.90893162
113MP0004233_abnormal_muscle_weight0.90861373
114MP0003567_abnormal_fetal_cardiomyocyte0.90808494
115* MP0004085_abnormal_heartbeat0.90160978
116MP0002405_respiratory_system_inflammati0.89386620
117MP0004947_skin_inflammation0.88027902
118MP0002452_abnormal_antigen_presenting0.87898332
119MP0002106_abnormal_muscle_physiology0.87860813
120MP0004883_abnormal_blood_vessel0.87765166
121MP0005083_abnormal_biliary_tract0.86632951
122MP0005464_abnormal_platelet_physiology0.85387869
123MP0002295_abnormal_pulmonary_circulatio0.85247193
124MP0000920_abnormal_myelination0.83810055
125MP0005023_abnormal_wound_healing0.83572567
126MP0001845_abnormal_inflammatory_respons0.82841449
127MP0008004_abnormal_stomach_pH0.82720121
128MP0001756_abnormal_urination0.81445542
129MP0002118_abnormal_lipid_homeostasis0.81131172
130MP0000598_abnormal_liver_morphology0.80480431
131MP0001243_abnormal_dermal_layer0.79624591
132MP0001915_intracranial_hemorrhage0.79322202
133MP0002269_muscular_atrophy0.79292209
134MP0006036_abnormal_mitochondrial_physio0.78083424
135MP0010155_abnormal_intestine_physiology0.78020648
136MP0009764_decreased_sensitivity_to0.77548385
137MP0002723_abnormal_immune_serum0.75727596
138MP0003943_abnormal_hepatobiliary_system0.75019208
139MP0002136_abnormal_kidney_physiology0.74316243
140MP0003634_abnormal_glial_cell0.72374358
141MP0000747_muscle_weakness0.72241828
142MP0005164_abnormal_response_to0.72125070
143MP0008469_abnormal_protein_level0.72042956
144MP0004782_abnormal_surfactant_physiolog0.71887128
145MP0005623_abnormal_meninges_morphology0.71807745
146MP0002166_altered_tumor_susceptibility0.71158642
147MP0002060_abnormal_skin_morphology0.69987705
148MP0003221_abnormal_cardiomyocyte_apopto0.69760864
149MP0005369_muscle_phenotype0.68927653
150MP0005375_adipose_tissue_phenotype0.68897353
151MP0005584_abnormal_enzyme/coenzyme_acti0.68057727
152MP0003075_altered_response_to0.68009009
153MP0000685_abnormal_immune_system0.66742122

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.46897492
2Abnormality of liposaccharide metabolism (HP:0010968)5.46897492
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.46897492
4Dysostosis multiplex (HP:0000943)4.25649844
5Deep venous thrombosis (HP:0002625)4.20880421
6Ventricular tachycardia (HP:0004756)4.11384921
7* Polycythemia (HP:0001901)4.07522741
8Broad metatarsal (HP:0001783)3.79152582
9Sudden death (HP:0001699)3.77938875
10Abnormality of mucopolysaccharide metabolism (HP:0011020)3.54719303
11Abnormality of polysaccharide metabolism (HP:0011012)3.54719303
12Abnormality of glycosaminoglycan metabolism (HP:0004371)3.54719303
13Vertebral compression fractures (HP:0002953)3.46176421
14Increased cerebral lipofuscin (HP:0011813)3.45608308
15Mucopolysacchariduria (HP:0008155)3.44914057
16Urinary glycosaminoglycan excretion (HP:0003541)3.44914057
17Lymphangioma (HP:0100764)3.42502456
18Muscle fiber splitting (HP:0003555)3.40535587
19Protrusio acetabuli (HP:0003179)3.39413592
20Nonimmune hydrops fetalis (HP:0001790)3.38622940
21Increased connective tissue (HP:0009025)3.36163712
22Cerebral aneurysm (HP:0004944)3.27703814
23Vacuolated lymphocytes (HP:0001922)3.27597798
24Axonal loss (HP:0003447)3.21336962
25Lipoatrophy (HP:0100578)3.14383838
26Atrial fibrillation (HP:0005110)3.12298094
27Mesangial abnormality (HP:0001966)3.10301181
28Asymmetric septal hypertrophy (HP:0001670)3.05091081
29Nuclear cataract (HP:0100018)3.04569707
30Hypoglycemic coma (HP:0001325)3.00223665
31Supraventricular arrhythmia (HP:0005115)2.96677577
32Right ventricular cardiomyopathy (HP:0011663)2.95617058
33Loss of speech (HP:0002371)2.92880348
34Cervical subluxation (HP:0003308)2.88367810
35Abnormality of fatty-acid metabolism (HP:0004359)2.87247992
36Vascular tortuosity (HP:0004948)2.86740281
37Primary atrial arrhythmia (HP:0001692)2.86055426
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.84679174
39* Esophageal varix (HP:0002040)2.83553506
40Supraventricular tachycardia (HP:0004755)2.81210368
41Joint stiffness (HP:0001387)2.78371564
42Spondylolisthesis (HP:0003302)2.73849238
43Neurofibrillary tangles (HP:0002185)2.72248905
44Hyporeflexia of lower limbs (HP:0002600)2.71042520
45* Abnormality of the nasal mucosa (HP:0000433)2.70434772
46Abnormality of the intrinsic pathway (HP:0010989)2.69852966
47Joint hemorrhage (HP:0005261)2.69148259
48Aortic aneurysm (HP:0004942)2.68599582
49Complement deficiency (HP:0004431)2.67861173
50Atrioventricular block (HP:0001678)2.65205016
51Ketosis (HP:0001946)2.62583194
52Dilated cardiomyopathy (HP:0001644)2.61525303
53Abnormality of the left ventricular outflow tract (HP:0011103)2.60689136
54Subaortic stenosis (HP:0001682)2.60689136
55Myoglobinuria (HP:0002913)2.59327320
56Hemorrhage of the eye (HP:0011885)2.58774542
57Arterial tortuosity (HP:0005116)2.57707564
58Hyperammonemia (HP:0001987)2.55253282
59Ketoacidosis (HP:0001993)2.54518277
60Type 1 muscle fiber predominance (HP:0003803)2.50640048
61Abnormality of macrophages (HP:0004311)2.48335679
62Distal lower limb muscle weakness (HP:0009053)2.42823126
63Systemic lupus erythematosus (HP:0002725)2.42817873
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40095405
65Dicarboxylic aciduria (HP:0003215)2.40095405
66Xanthomatosis (HP:0000991)2.39811357
67Myocardial infarction (HP:0001658)2.39573333
68Intrahepatic cholestasis (HP:0001406)2.38518421
69Impaired platelet aggregation (HP:0003540)2.37733936
70Abnormal platelet function (HP:0011869)2.37733936
71Exercise-induced muscle cramps (HP:0003710)2.37352823
72Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36756341
73Wormian bones (HP:0002645)2.36018101
74Blue sclerae (HP:0000592)2.35997227
75Dilatation of the ascending aorta (HP:0005111)2.35473216
76Genu recurvatum (HP:0002816)2.34132335
77Chondrocalcinosis (HP:0000934)2.33914493
78Disinhibition (HP:0000734)2.33097825
79Mutism (HP:0002300)2.32601823
80* Spontaneous hematomas (HP:0007420)2.30929378
81Interstitial pulmonary disease (HP:0006530)2.28957140
82Bladder diverticulum (HP:0000015)2.28497566
83Palpitations (HP:0001962)2.28031831
84Nephritis (HP:0000123)2.26147977
85Upper motor neuron abnormality (HP:0002127)2.25812382
86Hyperlipoproteinemia (HP:0010980)2.25314049
87Generalized aminoaciduria (HP:0002909)2.23962227
88Slender build (HP:0001533)2.23747835
89Soft skin (HP:0000977)2.22055375
90Exercise-induced myalgia (HP:0003738)2.21710963
91Difficulty running (HP:0009046)2.21173705
92Wrist flexion contracture (HP:0001239)2.20962978
93* Aneurysm (HP:0002617)2.20284324
94Calf muscle hypertrophy (HP:0008981)2.19702046
95Aortic dissection (HP:0002647)2.16990600
96Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15498817
97Rhabdomyolysis (HP:0003201)2.15194483
98Prolonged bleeding time (HP:0003010)2.14968671
99Atrophic scars (HP:0001075)2.14861503
100Increased variability in muscle fiber diameter (HP:0003557)2.14639208
101Cerebral inclusion bodies (HP:0100314)2.12469487
102Abnormality of the common coagulation pathway (HP:0010990)2.12390147
103EMG: myopathic abnormalities (HP:0003458)2.11978083
104Abnormality of Sharpey fibers (HP:0100685)2.11035223
105Cardiovascular calcification (HP:0011915)2.10971536
106Pulmonary artery stenosis (HP:0004415)2.10124728
107Hyperglycinuria (HP:0003108)2.10061930
108Purpura (HP:0000979)2.09983583
109Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09935355
110Delayed CNS myelination (HP:0002188)2.09257619
111Fragile skin (HP:0001030)2.08962484
112Glomerulonephritis (HP:0000099)2.08892699
113* Hematochezia (HP:0002573)2.07290482
114Heart block (HP:0012722)2.06964912
115Aortic valve stenosis (HP:0001650)2.06879959
116Peritonitis (HP:0002586)2.06268755
117Achilles tendon contracture (HP:0001771)2.05240949
118Abnormality of complement system (HP:0005339)2.04508009
119Abnormality of skeletal muscle fiber size (HP:0012084)2.04246546
120Neonatal death (HP:0003811)2.01973373
121Thin bony cortex (HP:0002753)2.01936157
122Abnormal atrioventricular conduction (HP:0005150)2.01203324
123Distal upper limb amyotrophy (HP:0007149)2.00313832
124Upper limb amyotrophy (HP:0009129)2.00313832
125J-shaped sella turcica (HP:0002680)2.00265165
126Ovoid vertebral bodies (HP:0003300)1.99525229
127Apathy (HP:0000741)1.99437342
128Neoplasm of head and neck (HP:0012288)1.98531791
129Esophageal neoplasm (HP:0100751)1.98531791
130Follicular hyperkeratosis (HP:0007502)1.98530037
131Vascular calcification (HP:0004934)1.98451444
132Difficulty climbing stairs (HP:0003551)1.98190089
133Eczematoid dermatitis (HP:0000976)1.97942359
134Hypoalphalipoproteinemia (HP:0003233)1.97844350
135Distal lower limb amyotrophy (HP:0008944)1.97692746
136Mitral valve prolapse (HP:0001634)1.96101736
137Diminished motivation (HP:0000745)1.93823982
138Shallow orbits (HP:0000586)1.93676293
139Facial diplegia (HP:0001349)1.92941765
140Mildly elevated creatine phosphokinase (HP:0008180)1.92441649
141Myotonia (HP:0002486)1.92075778
142* Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90973688
143Osteolytic defects of the hand bones (HP:0009699)1.90541459
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.90541459
145Syncope (HP:0001279)1.90215419
146Prolonged partial thromboplastin time (HP:0003645)1.88973413
147Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88805937
148Menorrhagia (HP:0000132)1.86347939
149Abnormality of the calf musculature (HP:0001430)1.84806429
150Pathologic fracture (HP:0002756)1.83875404
151Recurrent abscess formation (HP:0002722)1.82186970
152Ankle contracture (HP:0006466)1.81794833
153Spinal rigidity (HP:0003306)1.80717238
154Gout (HP:0001997)1.80150166
155Hyperactive renin-angiotensin system (HP:0000841)1.79676440
156Premature rupture of membranes (HP:0001788)1.79383697
157Abnormality of the Achilles tendon (HP:0005109)1.79372583
158Generalized amyotrophy (HP:0003700)1.78983124
159Aortic regurgitation (HP:0001659)1.78699543
160Amyloidosis (HP:0011034)1.77772041
161Generalized muscle weakness (HP:0003324)1.77532039
162Muscle hypertrophy of the lower extremities (HP:0008968)1.77262013
163Increased serum ferritin (HP:0003281)1.77144961
164Abnormality of dentin (HP:0010299)1.75839662
165Ragged-red muscle fibers (HP:0003200)1.75612606
166Centrally nucleated skeletal muscle fibers (HP:0003687)1.75237904
167Abnormality of glycine metabolism (HP:0010895)1.75095630
168Abnormality of serine family amino acid metabolism (HP:0010894)1.75095630
169Joint laxity (HP:0001388)1.74809641
170Bone pain (HP:0002653)1.73225541
171Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72591782
172Progressive neurologic deterioration (HP:0002344)1.71035141
173Recurrent gram-negative bacterial infections (HP:0005420)1.70855728
174Emphysema (HP:0002097)1.70082790
175Coxa vara (HP:0002812)1.68395531
176Abnormality of the acetabulum (HP:0003170)1.67929461
177Mitral regurgitation (HP:0001653)1.67502718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.94124716
2KDR6.21398067
3ERN13.02931449
4DDR22.74011290
5IRAK32.60094741
6PKN22.38777758
7MYLK2.33174442
8BCKDK2.33008381
9TRIB32.32188107
10TESK12.10716110
11TTN2.07412593
12* TGFBR21.99974814
13RIPK11.93260165
14MAP2K31.90216677
15PRPF4B1.79962276
16CDC42BPA1.75969169
17FGFR41.66557418
18KIT1.49813163
19TAOK21.48546721
20MOS1.45722153
21FLT31.41808311
22ABL21.41560941
23MAP3K131.40787216
24MAP3K141.37368103
25LIMK11.32822886
26EPHB21.32474309
27WNK41.32320907
28LRRK21.26409587
29EPHB11.22737344
30PTK2B1.19726186
31PTK61.19447291
32MAP4K11.12015769
33PAK41.11571253
34NME21.11096416
35PDGFRA1.09880231
36TBK11.08333650
37ICK1.07455579
38LATS21.05160285
39PRKG21.05005897
40MAPK121.02727564
41MAP3K31.01684417
42RPS6KA21.00232736
43NTRK10.98657505
44MAP3K110.97418737
45SIK10.96186162
46JAK30.94014673
47DMPK0.93609484
48GRK10.91167917
49TAOK10.90421074
50ARAF0.89184224
51PDK20.89005071
52TRPM70.85474443
53ZAP700.84820505
54FGR0.84411105
55PRKD10.84329821
56MAP3K70.83114740
57MAPKAPK30.81912786
58TEC0.79854761
59TESK20.76700924
60LMTK20.76349165
61TYK20.76258999
62MARK20.71648148
63RPS6KC10.70770459
64RPS6KL10.70770459
65MUSK0.69439981
66STK100.68526443
67SMG10.68453148
68CSF1R0.67559815
69FER0.66134112
70MAP3K100.65417937
71CAMKK20.64833195
72CSK0.64624344
73PHKG10.62188175
74PHKG20.62188175
75MATK0.61942291
76MAPK150.61767534
77EEF2K0.61177420
78CAMK40.61080480
79PRKAA20.60615068
80PDK40.59261606
81PDK30.59261606
82RIPK40.58785019
83JAK10.58393407
84INSRR0.57277409
85IKBKB0.55799233
86FGFR30.55348713
87PIK3CA0.54653788
88JAK20.54600523
89ROCK10.54243554
90CAMK1D0.53794359
91NEK90.53401728
92MAP3K10.52700591
93HCK0.52447739
94RET0.48700755
95ILK0.48470428
96BTK0.48262527
97PAK20.48151143
98IRAK40.47739364
99OBSCN0.46383436
100ROCK20.46369905
101IKBKE0.44603544
102RPS6KA40.44467376
103PRKD20.43608347
104PTK20.42823234
105CAMK10.42505258
106MAPK110.41455957
107PINK10.39947484
108MAPK40.38978749
109KSR20.38333342
110PRKCH0.38230103
111SRC0.37135098
112EPHA30.36478841
113STK380.35529565
114LYN0.33985193
115GRK70.33838688
116CHUK0.32699320
117LCK0.32480842
118SYK0.31749552
119MAPK70.31589103
120IGF1R0.31289624
121EGFR0.31056642
122PIM20.31049569
123FES0.28992977
124PDGFRB0.28712179
125DAPK30.28096761
126GSK3A0.27484757
127MET0.26964060
128TAOK30.26963201
129MTOR0.26856960
130MAP2K20.26163367
131CAMK1G0.25070191
132BLK0.23290776
133PDPK10.22284132
134MAP2K60.21530024
135MAP3K60.21076568
136NLK0.21011698
137RPS6KA60.20953381
138PRKAA10.20308150

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.15300221
2Lysosome_Homo sapiens_hsa041423.10359247
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.98776978
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.89929658
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61001666
6Complement and coagulation cascades_Homo sapiens_hsa046102.54784880
7Propanoate metabolism_Homo sapiens_hsa006402.54524115
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52028565
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.43532132
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.32011264
11Arginine biosynthesis_Homo sapiens_hsa002202.15663825
12Tryptophan metabolism_Homo sapiens_hsa003802.04434986
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.03864498
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02572848
15PPAR signaling pathway_Homo sapiens_hsa033202.02258036
16Caffeine metabolism_Homo sapiens_hsa002322.02097154
17Fatty acid metabolism_Homo sapiens_hsa012122.01123632
18Rheumatoid arthritis_Homo sapiens_hsa053231.93964973
19Prion diseases_Homo sapiens_hsa050201.93915253
20Nitrogen metabolism_Homo sapiens_hsa009101.88351713
21Staphylococcus aureus infection_Homo sapiens_hsa051501.74408717
22ECM-receptor interaction_Homo sapiens_hsa045121.71088973
23Phagosome_Homo sapiens_hsa041451.65603683
24Dilated cardiomyopathy_Homo sapiens_hsa054141.63063017
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.56183039
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55233082
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53716881
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52275329
29Carbon metabolism_Homo sapiens_hsa012001.50180198
30Bladder cancer_Homo sapiens_hsa052191.49499578
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48917804
32Tuberculosis_Homo sapiens_hsa051521.48841175
33Bile secretion_Homo sapiens_hsa049761.43949592
34Focal adhesion_Homo sapiens_hsa045101.42598766
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41516795
36Salmonella infection_Homo sapiens_hsa051321.37852895
37Peroxisome_Homo sapiens_hsa041461.37675183
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34475892
39Butanoate metabolism_Homo sapiens_hsa006501.32372869
40beta-Alanine metabolism_Homo sapiens_hsa004101.27525092
41Pyruvate metabolism_Homo sapiens_hsa006201.26450075
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22665508
43Insulin resistance_Homo sapiens_hsa049311.16760635
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.13913088
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.11095491
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.10997671
47ABC transporters_Homo sapiens_hsa020101.09002934
48Malaria_Homo sapiens_hsa051441.07854446
49Lysine degradation_Homo sapiens_hsa003101.05698136
50Platelet activation_Homo sapiens_hsa046111.04241834
51Starch and sucrose metabolism_Homo sapiens_hsa005001.02313992
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02293864
53Hematopoietic cell lineage_Homo sapiens_hsa046401.00795607
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00440352
55Asthma_Homo sapiens_hsa053100.98801111
56Shigellosis_Homo sapiens_hsa051310.98371689
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97614279
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97543786
59Selenocompound metabolism_Homo sapiens_hsa004500.97340826
60Vibrio cholerae infection_Homo sapiens_hsa051100.96759459
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95631578
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95226094
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94802306
64Small cell lung cancer_Homo sapiens_hsa052220.94242124
65Allograft rejection_Homo sapiens_hsa053300.91343576
66Chemical carcinogenesis_Homo sapiens_hsa052040.91015037
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90532340
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88501886
69Fatty acid elongation_Homo sapiens_hsa000620.87490770
70Amoebiasis_Homo sapiens_hsa051460.87300752
71Mineral absorption_Homo sapiens_hsa049780.85987005
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85356712
73Biosynthesis of amino acids_Homo sapiens_hsa012300.85242470
74Antigen processing and presentation_Homo sapiens_hsa046120.84347552
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.84308887
76Folate biosynthesis_Homo sapiens_hsa007900.84263162
77Vitamin digestion and absorption_Homo sapiens_hsa049770.83973264
78Viral myocarditis_Homo sapiens_hsa054160.83360214
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82292047
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81878291
81Notch signaling pathway_Homo sapiens_hsa043300.80927988
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.79726883
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.78935555
84Graft-versus-host disease_Homo sapiens_hsa053320.78916252
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78078323
86B cell receptor signaling pathway_Homo sapiens_hsa046620.77598946
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76745636
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76546106
89Chronic myeloid leukemia_Homo sapiens_hsa052200.76307341
90Protein digestion and absorption_Homo sapiens_hsa049740.76035787
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75761467
92Influenza A_Homo sapiens_hsa051640.75241023
93Autoimmune thyroid disease_Homo sapiens_hsa053200.75086674
94Endocytosis_Homo sapiens_hsa041440.74476893
95Legionellosis_Homo sapiens_hsa051340.74198659
96Sulfur relay system_Homo sapiens_hsa041220.72774268
97Chemokine signaling pathway_Homo sapiens_hsa040620.72517314
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.71452480
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70838323
100Arginine and proline metabolism_Homo sapiens_hsa003300.68885973
101Adherens junction_Homo sapiens_hsa045200.68538094
102Fat digestion and absorption_Homo sapiens_hsa049750.68103086
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.67322964
104Hepatitis B_Homo sapiens_hsa051610.67162450
105Renin-angiotensin system_Homo sapiens_hsa046140.65830519
106Toxoplasmosis_Homo sapiens_hsa051450.65774608
107Apoptosis_Homo sapiens_hsa042100.64188871
108Sphingolipid metabolism_Homo sapiens_hsa006000.64075294
109GnRH signaling pathway_Homo sapiens_hsa049120.63420990
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.62620517
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62547318
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62115769
113Retinol metabolism_Homo sapiens_hsa008300.61767795
114Hepatitis C_Homo sapiens_hsa051600.60501291
115Pancreatic cancer_Homo sapiens_hsa052120.58646293
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57919981
117HIF-1 signaling pathway_Homo sapiens_hsa040660.57731421
118Galactose metabolism_Homo sapiens_hsa000520.57556183
119Rap1 signaling pathway_Homo sapiens_hsa040150.57086428
120Renal cell carcinoma_Homo sapiens_hsa052110.57067116
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55962672
122Collecting duct acid secretion_Homo sapiens_hsa049660.55596222
123Histidine metabolism_Homo sapiens_hsa003400.53012711
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.52664388
125Phenylalanine metabolism_Homo sapiens_hsa003600.51534065
126Proteoglycans in cancer_Homo sapiens_hsa052050.51039444
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.49357350
128Acute myeloid leukemia_Homo sapiens_hsa052210.49174812
129VEGF signaling pathway_Homo sapiens_hsa043700.47928632
130Other glycan degradation_Homo sapiens_hsa005110.47905021
131Pertussis_Homo sapiens_hsa051330.47653065
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47581953
133Sulfur metabolism_Homo sapiens_hsa009200.46628852
134Estrogen signaling pathway_Homo sapiens_hsa049150.46500371
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44895072
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44498919
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44098008
138Pentose phosphate pathway_Homo sapiens_hsa000300.43404837
139African trypanosomiasis_Homo sapiens_hsa051430.43165461
140HTLV-I infection_Homo sapiens_hsa051660.43135048
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42037593
142AMPK signaling pathway_Homo sapiens_hsa041520.40910402
143Prolactin signaling pathway_Homo sapiens_hsa049170.40683893
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40446641
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40418341
146Pathways in cancer_Homo sapiens_hsa052000.40217696
147Cardiac muscle contraction_Homo sapiens_hsa042600.40090359
148Tyrosine metabolism_Homo sapiens_hsa003500.39718302
149Ovarian steroidogenesis_Homo sapiens_hsa049130.39496067
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.39398815
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39017579
152Leishmaniasis_Homo sapiens_hsa051400.37984007
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37628402
154Jak-STAT signaling pathway_Homo sapiens_hsa046300.37541464
155Fructose and mannose metabolism_Homo sapiens_hsa000510.37033786
156Osteoclast differentiation_Homo sapiens_hsa043800.36402645
157Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35644059
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34551097
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33022699
160TNF signaling pathway_Homo sapiens_hsa046680.32299684
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.31243405

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