ENGASE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of apoptotic cell clearance (GO:2000425)9.49604283
2regulation of integrin activation (GO:0033623)9.24816068
3mannose metabolic process (GO:0006013)8.09376591
4complement activation, alternative pathway (GO:0006957)7.26068980
5regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)7.25499198
6apoptotic cell clearance (GO:0043277)6.80709096
7lipoxygenase pathway (GO:0019372)6.77362898
8endothelial cell chemotaxis (GO:0035767)5.96407587
9citrulline biosynthetic process (GO:0019240)5.88712856
10germinal center formation (GO:0002467)5.53479021
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.48760724
12negative regulation of cell killing (GO:0031342)5.48760724
13regulation of endothelial cell chemotaxis (GO:2001026)5.38570739
14negative regulation of granulocyte differentiation (GO:0030853)5.27896716
15positive regulation of gamma-delta T cell activation (GO:0046645)4.91678377
16complement activation (GO:0006956)4.87175198
17leukotriene metabolic process (GO:0006691)4.73983127
18opsonization (GO:0008228)4.66484194
19positive regulation of cell adhesion mediated by integrin (GO:0033630)4.47814549
20regulation of T cell chemotaxis (GO:0010819)4.36658906
21positive regulation of T cell chemotaxis (GO:0010820)4.36658906
22regulation of complement activation (GO:0030449)4.34197668
23cellular extravasation (GO:0045123)4.32426546
24positive regulation of Rap GTPase activity (GO:0032854)4.15156969
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07030694
26negative regulation of interleukin-12 production (GO:0032695)4.03633488
27regulation of protein activation cascade (GO:2000257)4.02525245
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.99734204
29regulation of macrophage chemotaxis (GO:0010758)3.99685458
30primary alcohol catabolic process (GO:0034310)3.97084751
31regulation of phagocytosis (GO:0050764)3.96895417
32regulation of gamma-delta T cell activation (GO:0046643)3.95310100
33regulation of humoral immune response (GO:0002920)3.94049626
34positive regulation of chemokine secretion (GO:0090197)3.92583891
35response to muramyl dipeptide (GO:0032495)3.84197632
36detection of bacterium (GO:0016045)3.82550193
37complement activation, classical pathway (GO:0006958)3.79968011
38detection of other organism (GO:0098543)3.78118585
39citrulline metabolic process (GO:0000052)3.77593770
40icosanoid biosynthetic process (GO:0046456)3.77566602
41fatty acid derivative biosynthetic process (GO:1901570)3.77566602
42leukotriene biosynthetic process (GO:0019370)3.77025028
43long-chain fatty acid biosynthetic process (GO:0042759)3.74384962
44regulation of gamma-delta T cell differentiation (GO:0045586)3.74208123
45positive thymic T cell selection (GO:0045059)3.72474081
46protein activation cascade (GO:0072376)3.69684216
47adaptation of signaling pathway (GO:0023058)3.66655927
48detection of molecule of bacterial origin (GO:0032490)3.60930116
49response to peptidoglycan (GO:0032494)3.57791338
50leukocyte tethering or rolling (GO:0050901)3.55819573
51regulation of chemokine secretion (GO:0090196)3.55357159
52regulation of T cell migration (GO:2000404)3.53242059
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49168553
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49168553
55negative regulation of erythrocyte differentiation (GO:0045647)3.46001204
56thymic T cell selection (GO:0045061)3.43987385
57regulation of Rap GTPase activity (GO:0032317)3.40924449
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.36777082
59regulation of B cell receptor signaling pathway (GO:0050855)3.32170436
60ethanol metabolic process (GO:0006067)3.31465763
61chronic inflammatory response (GO:0002544)3.30424323
62defense response to fungus (GO:0050832)3.27127477
63ethanol oxidation (GO:0006069)3.26770759
64positive regulation of antigen processing and presentation (GO:0002579)3.25606505
65cytokine production involved in immune response (GO:0002367)3.22826306
66negative thymic T cell selection (GO:0045060)3.22477443
67viral transcription (GO:0019083)3.20744842
68positive regulation of phagocytosis (GO:0050766)3.19402428
69T cell selection (GO:0045058)3.19171232
70cyclooxygenase pathway (GO:0019371)3.14079392
71positive regulation of cholesterol efflux (GO:0010875)3.10126748
72leukocyte aggregation (GO:0070486)3.09830008
73negative regulation of interleukin-6 production (GO:0032715)3.08848628
74protein carboxylation (GO:0018214)3.06001950
75peptidyl-glutamic acid carboxylation (GO:0017187)3.06001950
76detection of external biotic stimulus (GO:0098581)3.04882341
77regulation of interferon-beta biosynthetic process (GO:0045357)3.03122374
78unsaturated fatty acid biosynthetic process (GO:0006636)3.02185069
79regulation of cholesterol storage (GO:0010885)3.01204611
80translational termination (GO:0006415)3.00220325
81positive regulation by symbiont of host defense response (GO:0052509)2.98569211
82modulation by symbiont of host defense response (GO:0052031)2.98569211
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98569211
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98569211
85positive regulation by organism of defense response of other organism involved in symbiotic interact2.98569211
86modulation by symbiont of host immune response (GO:0052553)2.98569211
87neutrophil activation involved in immune response (GO:0002283)2.98285683
88negative T cell selection (GO:0043383)2.97682913
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94064468
90immunoglobulin mediated immune response (GO:0016064)2.93401166
91production of molecular mediator of immune response (GO:0002440)2.90561892
92phosphatidylethanolamine biosynthetic process (GO:0006646)2.90194132
93negative regulation of toll-like receptor signaling pathway (GO:0034122)2.89988374
94regulation of leukocyte degranulation (GO:0043300)2.88430854
95positive regulation of T cell migration (GO:2000406)2.86674407
96regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86638597
97NIK/NF-kappaB signaling (GO:0038061)2.86302012
98positive regulation of cholesterol transport (GO:0032376)2.84523150
99positive regulation of sterol transport (GO:0032373)2.84523150
100positive T cell selection (GO:0043368)2.84412110
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.84373462
102negative regulation of lymphocyte mediated immunity (GO:0002707)2.83110779
103antigen processing and presentation of endogenous antigen (GO:0019883)2.81699605
104arachidonic acid metabolic process (GO:0019369)2.80057756
105regulation of mast cell degranulation (GO:0043304)2.79805696
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78696581
107lymphocyte chemotaxis (GO:0048247)2.77917774
108hyaluronan catabolic process (GO:0030214)2.77868874
109negative regulation of leukocyte mediated immunity (GO:0002704)2.77422277
110leukocyte cell-cell adhesion (GO:0007159)2.76450217
111positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76044654
112phospholipid efflux (GO:0033700)2.75795696
113pinocytosis (GO:0006907)2.75612072
114regulation of antigen processing and presentation (GO:0002577)2.75378830
115detection of biotic stimulus (GO:0009595)2.74328946
116positive regulation of Cdc42 GTPase activity (GO:0043089)2.73783710
117histone H3-K36 demethylation (GO:0070544)2.73377332
118phagocytosis (GO:0006909)2.72674674
119regulation of ARF GTPase activity (GO:0032312)2.72330545
120regulation of T-helper 2 cell differentiation (GO:0045628)2.71326154
121ribosomal small subunit assembly (GO:0000028)2.70808741
122positive regulation of hemostasis (GO:1900048)2.70590765
123positive regulation of blood coagulation (GO:0030194)2.70590765
124regulation of T cell tolerance induction (GO:0002664)2.70570669
125B cell receptor signaling pathway (GO:0050853)2.70455111
126peptidyl-arginine modification (GO:0018195)2.69034547
127regulation of respiratory burst (GO:0060263)2.67315765
128negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67136389
129production of molecular mediator involved in inflammatory response (GO:0002532)2.66920811
130negative regulation of innate immune response (GO:0045824)2.66913886
131positive regulation of coagulation (GO:0050820)2.66612036
132macrophage activation involved in immune response (GO:0002281)2.65009177
133negative regulation of myotube differentiation (GO:0010832)2.64831250
134lymph node development (GO:0048535)2.64752565
135positive regulation of B cell differentiation (GO:0045579)2.64733517
136antigen processing and presentation via MHC class Ib (GO:0002475)2.63389931
137regulation of cell adhesion mediated by integrin (GO:0033628)2.62897593
138response to laminar fluid shear stress (GO:0034616)2.61221139
139triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.60960393
140regulation of necroptotic process (GO:0060544)2.59950912
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57847089
142negative regulation of T cell mediated immunity (GO:0002710)2.57282655
1433-UTR-mediated mRNA stabilization (GO:0070935)2.56241280
144negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.55932822
145regulation of tolerance induction (GO:0002643)2.54237615
146response to type I interferon (GO:0034340)2.52288384
147regulation of extracellular matrix disassembly (GO:0010715)2.49861329
148phospholipid scrambling (GO:0017121)2.49438995
149tolerance induction (GO:0002507)2.49375283
150cellular response to type I interferon (GO:0071357)2.48565729
151type I interferon signaling pathway (GO:0060337)2.48565729
152negative regulation of cytokine production involved in immune response (GO:0002719)2.47206455
153signal complex assembly (GO:0007172)2.46187685
154regulation of mast cell activation involved in immune response (GO:0033006)2.43760492
155negative regulation of type 2 immune response (GO:0002829)2.42139554
156lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37906048
157defense response to protozoan (GO:0042832)2.37409324
158positive regulation of cellular amide metabolic process (GO:0034250)2.36438450
159interferon-gamma-mediated signaling pathway (GO:0060333)2.35262758
160regulation of B cell differentiation (GO:0045577)2.32194504
161regulation of interleukin-2 biosynthetic process (GO:0045076)2.31599546
162T cell migration (GO:0072678)2.31110833
163activation of JUN kinase activity (GO:0007257)2.28439796
164regulation of necrotic cell death (GO:0010939)2.26996569
165regulation of ARF protein signal transduction (GO:0032012)2.26803471
166regulation of regulated secretory pathway (GO:1903305)2.26190334
167regulation of granulocyte differentiation (GO:0030852)2.25443337
168modulation by symbiont of host cellular process (GO:0044068)2.24521854
169positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.24377414
170response to host (GO:0075136)2.24040382
171response to host defenses (GO:0052200)2.24040382
172response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.24040382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.07363071
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.88529287
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.83719263
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.79464646
5VDR_21846776_ChIP-Seq_THP-1_Human2.71851837
6MYC_22102868_ChIP-Seq_BL_Human2.62875027
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.62033702
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.54907391
9E2F7_22180533_ChIP-Seq_HELA_Human2.46876855
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.33531293
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27609170
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.14924654
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10843079
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10052741
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07227719
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04662001
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.02619492
18* LXR_22292898_ChIP-Seq_THP-1_Human2.02611124
19TCF7_22412390_ChIP-Seq_EML_Mouse2.01906100
20SCL_19346495_ChIP-Seq_HPC-7_Human1.96232344
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.88008224
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87216589
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.85812496
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84587175
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81837976
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80335803
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78488847
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.78485833
29VDR_24763502_ChIP-Seq_THP-1_Human1.76390386
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75978201
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72826577
32* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68305934
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66533211
34KDM2B_26808549_Chip-Seq_K562_Human1.65423484
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64352142
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62052908
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61149054
38SPI1_23127762_ChIP-Seq_K562_Human1.58669875
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.58174795
40MAF_26560356_Chip-Seq_TH1_Human1.56928568
41RACK7_27058665_Chip-Seq_MCF-7_Human1.56142922
42KDM2B_26808549_Chip-Seq_DND41_Human1.55844838
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54584557
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52044901
45UTX_26944678_Chip-Seq_JUKART_Human1.51287342
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.45263617
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.45003049
48SPI1_23547873_ChIP-Seq_NB4_Human1.44039927
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41487817
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41454245
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41408986
52SMC4_20622854_ChIP-Seq_HELA_Human1.40258292
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38485443
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37766883
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.37516044
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.37159830
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37030583
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36876187
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35745792
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31925760
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31537684
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31173585
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31080468
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31020566
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29812874
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.28458716
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.27860189
68MAF_26560356_Chip-Seq_TH2_Human1.26340590
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22444756
70CREB1_26743006_Chip-Seq_LNCaP_Human1.22439360
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22438229
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22270095
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22116824
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21764525
75* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20247265
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18694428
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18316711
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17338059
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16854336
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16788283
81GATA1_22025678_ChIP-Seq_K562_Human1.15759066
82STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15582760
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15092412
84* P68_20966046_ChIP-Seq_HELA_Human1.14997897
85GATA6_25053715_ChIP-Seq_YYC3_Human1.14899955
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14561353
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13905840
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13610180
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.12762011
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12433354
91SPI1_20517297_ChIP-Seq_HL60_Human1.11451823
92* NCOR1_26117541_ChIP-Seq_K562_Human1.10550073
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10221169
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09511636
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09090072
96BCOR_27268052_Chip-Seq_Bcells_Human1.08678679
97CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08408602
98ATF3_27146783_Chip-Seq_COLON_Human1.07908579
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07006271
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06362960
101* PHF8_20622854_ChIP-Seq_HELA_Human1.05627089
102GATA1_19941826_ChIP-Seq_K562_Human1.05449175
103RUNX_20019798_ChIP-Seq_JUKART_Human1.04737843
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04044111
105DROSHA_22980978_ChIP-Seq_HELA_Human1.03625744
106* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03103712
107GATA2_19941826_ChIP-Seq_K562_Human1.02685888
108MYB_26560356_Chip-Seq_TH2_Human1.02299183
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.02259268
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01751600
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01653800
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00876373
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00804487
114P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00532071
115BCL6_27268052_Chip-Seq_Bcells_Human1.00159444
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99320433
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99131161
118* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99021074
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98645276
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98333842
121MYB_26560356_Chip-Seq_TH1_Human0.98203473
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97190140
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.96582283
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95861332
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95516341
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95197073
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93591569
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93458443
129MYC_18555785_ChIP-Seq_MESCs_Mouse0.93013332
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92980961
131* RUNX1_27514584_Chip-Seq_MCF-7_Human0.92330261
132ZNF263_19887448_ChIP-Seq_K562_Human0.91508672
133* SA1_27219007_Chip-Seq_ERYTHROID_Human0.90835428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.28091365
2MP0009840_abnormal_foam_cell3.81021689
3MP0003705_abnormal_hypodermis_morpholog2.75976609
4MP0003191_abnormal_cellular_cholesterol2.62623118
5MP0008004_abnormal_stomach_pH2.51801833
6MP0003436_decreased_susceptibility_to2.48597324
7MP0005451_abnormal_body_composition2.47116903
8MP0003300_gastrointestinal_ulcer2.41538132
9MP0009333_abnormal_splenocyte_physiolog2.35662651
10MP0003724_increased_susceptibility_to2.33697227
11MP0000685_abnormal_immune_system2.24084464
12MP0004947_skin_inflammation2.22794164
13MP0001790_abnormal_immune_system2.14216861
14MP0005387_immune_system_phenotype2.14216861
15MP0008260_abnormal_autophagy2.13571235
16MP0001849_ear_inflammation2.10284268
17MP0003075_altered_response_to2.04829827
18MP0005025_abnormal_response_to1.98424632
19MP0005464_abnormal_platelet_physiology1.94237432
20MP0005360_urolithiasis1.94169971
21MP0000490_abnormal_crypts_of1.89467567
22MP0002419_abnormal_innate_immunity1.84001650
23MP0002396_abnormal_hematopoietic_system1.83015198
24MP0005671_abnormal_response_to1.81329603
25MP0003172_abnormal_lysosome_physiology1.75322655
26MP0003303_peritoneal_inflammation1.73478135
27MP0005670_abnormal_white_adipose1.71754775
28MP0008438_abnormal_cutaneous_collagen1.70684299
29MP0001800_abnormal_humoral_immune1.68389952
30MP0001533_abnormal_skeleton_physiology1.67481331
31MP0004185_abnormal_adipocyte_glucose1.66776307
32MP0005000_abnormal_immune_tolerance1.63481523
33MP0001873_stomach_inflammation1.62943139
34MP0002148_abnormal_hypersensitivity_rea1.61238643
35MP0003566_abnormal_cell_adhesion1.61068213
36MP0002452_abnormal_antigen_presenting1.56005679
37MP0002998_abnormal_bone_remodeling1.52582751
38MP0002166_altered_tumor_susceptibility1.47296484
39MP0003828_pulmonary_edema1.46519367
40MP0001851_eye_inflammation1.46513826
41MP0004858_abnormal_nervous_system1.45806783
42MP0003656_abnormal_erythrocyte_physiolo1.45216053
43MP0000858_altered_metastatic_potential1.44976234
44MP0000465_gastrointestinal_hemorrhage1.44591440
45MP0010329_abnormal_lipoprotein_level1.44431520
46MP0002405_respiratory_system_inflammati1.42889812
47MP0000604_amyloidosis1.42120531
48MP0000689_abnormal_spleen_morphology1.40728027
49MP0010352_gastrointestinal_tract_polyps1.38663578
50MP0010155_abnormal_intestine_physiology1.38502750
51MP0002420_abnormal_adaptive_immunity1.37094994
52MP0005023_abnormal_wound_healing1.36948311
53MP0005409_darkened_coat_color1.34600859
54MP0001819_abnormal_immune_cell1.34478004
55MP0001835_abnormal_antigen_presentation1.32619871
56MP0001845_abnormal_inflammatory_respons1.32445195
57MP0001915_intracranial_hemorrhage1.32269378
58MP0010368_abnormal_lymphatic_system1.29084809
59MP0002139_abnormal_hepatobiliary_system1.28725283
60MP0006054_spinal_hemorrhage1.27959508
61MP0001663_abnormal_digestive_system1.27480585
62MP0004264_abnormal_extraembryonic_tissu1.26397808
63MP0002722_abnormal_immune_system1.25880999
64MP0002254_reproductive_system_inflammat1.25508076
65MP0002723_abnormal_immune_serum1.23582107
66MP0005365_abnormal_bile_salt1.23468540
67MP0004510_myositis1.23228274
68MP0000716_abnormal_immune_system1.20170432
69MP0005166_decreased_susceptibility_to1.18853009
70MP0009278_abnormal_bone_marrow1.18571330
71MP0003091_abnormal_cell_migration1.17497153
72MP0006082_CNS_inflammation1.15738263
73MP0000249_abnormal_blood_vessel1.14107815
74MP0002009_preneoplasia1.13527360
75MP0002132_abnormal_respiratory_system1.13347356
76MP0000703_abnormal_thymus_morphology1.13264754
77MP0000609_abnormal_liver_physiology1.12770201
78MP0002398_abnormal_bone_marrow1.10913111
79MP0009763_increased_sensitivity_to1.09707768
80MP0005666_abnormal_adipose_tissue1.09696603
81MP0002429_abnormal_blood_cell1.09400123
82MP0005085_abnormal_gallbladder_physiolo1.09156487
83MP0004130_abnormal_muscle_cell1.06522286
84MP0005310_abnormal_salivary_gland1.06423429
85MP0004019_abnormal_vitamin_homeostasis1.06034923
86MP0000678_abnormal_parathyroid_gland1.05439397
87MP0005397_hematopoietic_system_phenotyp1.05269062
88MP0001545_abnormal_hematopoietic_system1.05269062
89MP0005375_adipose_tissue_phenotype1.05140880
90MP0008469_abnormal_protein_level1.04935031
91MP0009379_abnormal_foot_pigmentation1.03847698
92MP0002136_abnormal_kidney_physiology1.02297933
93MP0001853_heart_inflammation1.01689132
94MP0010234_abnormal_vibrissa_follicle1.01536945
95MP0005174_abnormal_tail_pigmentation1.00992592
96MP0004381_abnormal_hair_follicle0.99411129
97MP0000477_abnormal_intestine_morphology0.98104161
98MP0009643_abnormal_urine_homeostasis0.96903813
99MP0003183_abnormal_peptide_metabolism0.96889744
100MP0005076_abnormal_cell_differentiation0.95725148
101MP0003279_aneurysm0.95009904
102MP0001666_abnormal_nutrient_absorption0.92711946
103MP0004272_abnormal_basement_membrane0.92514632
104MP0000751_myopathy0.89698158
105MP0003866_abnormal_defecation0.89621333
106MP0005381_digestive/alimentary_phenotyp0.89369464
107MP0003453_abnormal_keratinocyte_physiol0.89316164
108MP0009785_altered_susceptibility_to0.89073005
109MP0000598_abnormal_liver_morphology0.88702844
110MP0003690_abnormal_glial_cell0.86777735
111MP0004808_abnormal_hematopoietic_stem0.85860776
112MP0005165_increased_susceptibility_to0.85821768
113MP0003329_amyloid_beta_deposits0.85310959
114MP0008875_abnormal_xenobiotic_pharmacok0.84334226
115MP0005390_skeleton_phenotype0.83945693
116MP0002060_abnormal_skin_morphology0.83183658
117MP0002933_joint_inflammation0.82955807
118MP0002971_abnormal_brown_adipose0.82882446
119MP0003763_abnormal_thymus_physiology0.82716110
120MP0003638_abnormal_response/metabolism_0.82016130
121MP0003045_fibrosis0.81861447
122MP0002006_tumorigenesis0.80220427
123MP0002138_abnormal_hepatobiliary_system0.79421979
124MP0005319_abnormal_enzyme/_coenzyme0.79162252
125MP0000733_abnormal_muscle_development0.77688572
126MP0005083_abnormal_biliary_tract0.77310978
127MP0003448_altered_tumor_morphology0.76984330
128MP0000767_abnormal_smooth_muscle0.75861729
129MP0004883_abnormal_blood_vessel0.74091435
130MP0009764_decreased_sensitivity_to0.73452195
131MP0006138_congestive_heart_failure0.73448042

Predicted human phenotypes

RankGene SetZ-score
1Glomerulonephritis (HP:0000099)7.05976805
2Abnormality of complement system (HP:0005339)6.32216089
3Complement deficiency (HP:0004431)6.16306977
4Dysostosis multiplex (HP:0000943)5.71817019
5Vacuolated lymphocytes (HP:0001922)5.27768736
6Urinary glycosaminoglycan excretion (HP:0003541)4.44619168
7Mucopolysacchariduria (HP:0008155)4.44619168
8Abnormality of mucopolysaccharide metabolism (HP:0011020)4.14157802
9Abnormality of polysaccharide metabolism (HP:0011012)4.14157802
10Abnormality of glycosaminoglycan metabolism (HP:0004371)4.14157802
11Nephritis (HP:0000123)4.11583107
12Shallow orbits (HP:0000586)4.04165244
13Pustule (HP:0200039)3.98995226
14Asymmetric septal hypertrophy (HP:0001670)3.92632236
15Cerebral aneurysm (HP:0004944)3.76970426
16Spondylolisthesis (HP:0003302)3.52549523
17Recurrent gram-negative bacterial infections (HP:0005420)3.32488379
18Recurrent abscess formation (HP:0002722)3.24054373
19Loss of speech (HP:0002371)3.22474260
20Joint stiffness (HP:0001387)3.21842408
21Deep venous thrombosis (HP:0002625)3.20817344
22Myositis (HP:0100614)3.16298450
23Prolonged bleeding time (HP:0003010)3.14970715
24Nasal polyposis (HP:0100582)3.13730336
25Increased IgE level (HP:0003212)3.08714695
26Cervical subluxation (HP:0003308)3.07617214
27Abnormality of the nasal mucosa (HP:0000433)2.95589647
28Abnormality of the fingertips (HP:0001211)2.87231257
29Menorrhagia (HP:0000132)2.85530105
30Obstructive sleep apnea (HP:0002870)2.76012009
31Orchitis (HP:0100796)2.71700445
32Thin bony cortex (HP:0002753)2.71048233
33Malnutrition (HP:0004395)2.69363543
34Cellulitis (HP:0100658)2.68168496
35Exercise-induced myalgia (HP:0003738)2.67748412
36Gastrointestinal infarctions (HP:0005244)2.67658954
37Thoracic kyphosis (HP:0002942)2.67505666
38Polygenic inheritance (HP:0010982)2.67454593
39Increased cerebral lipofuscin (HP:0011813)2.66035810
40Peritonitis (HP:0002586)2.62004911
41Eczematoid dermatitis (HP:0000976)2.60468928
42Hemorrhage of the eye (HP:0011885)2.58392463
43J-shaped sella turcica (HP:0002680)2.58134623
44Bronchomalacia (HP:0002780)2.56280935
45Periodontitis (HP:0000704)2.55414563
46Chronic obstructive pulmonary disease (HP:0006510)2.53037028
47Obstructive lung disease (HP:0006536)2.53037028
48Mediastinal lymphadenopathy (HP:0100721)2.52923429
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.52486416
50Meningitis (HP:0001287)2.48445012
51Deformed sella turcica (HP:0002681)2.46950781
52Hand muscle atrophy (HP:0009130)2.46755131
53Elevated erythrocyte sedimentation rate (HP:0003565)2.42944771
54Flat acetabular roof (HP:0003180)2.37323391
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.35311681
56Esophageal varix (HP:0002040)2.34537242
57Wrist flexion contracture (HP:0001239)2.32043830
58Recurrent bacterial skin infections (HP:0005406)2.31446087
59Increased connective tissue (HP:0009025)2.30431094
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.29359460
61Optic neuritis (HP:0100653)2.29224295
62Retrobulbar optic neuritis (HP:0100654)2.29224295
63Abnormality of the thoracic spine (HP:0100711)2.28704238
64Distal lower limb amyotrophy (HP:0008944)2.26326674
65Myopathic facies (HP:0002058)2.22389346
66Recurrent skin infections (HP:0001581)2.21100949
67IgM deficiency (HP:0002850)2.19043227
68Segmental peripheral demyelination/remyelination (HP:0003481)2.17866344
69Prolonged partial thromboplastin time (HP:0003645)2.17466534
70Abnormality of the lumbar spine (HP:0100712)2.16907805
71Amyloidosis (HP:0011034)2.15723247
72Enlarged penis (HP:0000040)2.15259234
73Impaired platelet aggregation (HP:0003540)2.14554745
74Abnormal platelet function (HP:0011869)2.14554745
75Vasculitis (HP:0002633)2.14153213
76Chest pain (HP:0100749)2.13202600
77Inflammation of the large intestine (HP:0002037)2.11431390
78Colitis (HP:0002583)2.10921691
79Coarse hair (HP:0002208)2.08207178
80Gastrointestinal stroma tumor (HP:0100723)2.07398676
81Panhypogammaglobulinemia (HP:0003139)2.06617308
82Chronic mucocutaneous candidiasis (HP:0002728)2.06541215
83Recurrent cutaneous fungal infections (HP:0011370)2.06541215
84Interstitial pulmonary disease (HP:0006530)2.06457913
85Multifactorial inheritance (HP:0001426)2.06289001
86Epistaxis (HP:0000421)2.05655183
87Abnormality of the common coagulation pathway (HP:0010990)2.05387112
88Emphysema (HP:0002097)2.04541216
89Broad metatarsal (HP:0001783)2.04273734
90Gastrointestinal inflammation (HP:0004386)2.02642417
91Vertebral hypoplasia (HP:0008417)2.02229451
92Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.02229451
93Severe short stature (HP:0003510)2.01640632
94Reticulocytopenia (HP:0001896)2.01135625
95Easy fatigability (HP:0003388)2.00282091
96Systemic lupus erythematosus (HP:0002725)10.0824908
97Neurofibrillary tangles (HP:0002185)1.98524681
98Ovoid vertebral bodies (HP:0003300)1.98477409
99Metaphyseal cupping (HP:0003021)1.97982462
100Increased serum ferritin (HP:0003281)1.97213395
101Spontaneous hematomas (HP:0007420)1.96631932
102Arterial tortuosity (HP:0005116)1.95683812
103Hypertriglyceridemia (HP:0002155)1.95480985
104Toxemia of pregnancy (HP:0100603)1.93545390
105Purpura (HP:0000979)1.93377752
106Broad face (HP:0000283)1.92572610
107Axonal loss (HP:0003447)1.92553034
108Hemoptysis (HP:0002105)1.91942518
109Encephalitis (HP:0002383)1.91734706
110Thrombocytosis (HP:0001894)1.91632431
111Arthropathy (HP:0003040)1.91358523
112Beaking of vertebral bodies (HP:0004568)1.90076572
113Cerebral inclusion bodies (HP:0100314)1.89989719
114Upper limb amyotrophy (HP:0009129)1.89626909
115Distal upper limb amyotrophy (HP:0007149)1.89626909
116Distal lower limb muscle weakness (HP:0009053)1.89610309
11711 pairs of ribs (HP:0000878)1.88958164
118Agammaglobulinemia (HP:0004432)1.88580653
119Petechiae (HP:0000967)1.87582754
120Global brain atrophy (HP:0002283)1.87312941
121Aneurysm (HP:0002617)1.87000922
122Abnormal hemoglobin (HP:0011902)1.86520492
123Increased variability in muscle fiber diameter (HP:0003557)1.86067007
124Pathologic fracture (HP:0002756)1.85836271
125Large eyes (HP:0001090)1.85379829
126Abnormality of liposaccharide metabolism (HP:0010968)1.85285515
127Abnormality of glycosphingolipid metabolism (HP:0004343)1.85285515
128Abnormality of glycolipid metabolism (HP:0010969)1.85285515
129Osteomyelitis (HP:0002754)1.84266106
130Abnormality of macrophages (HP:0004311)1.82432633
131Stridor (HP:0010307)1.82174242
132Abnormality of skeletal muscle fiber size (HP:0012084)1.82119205
133Milia (HP:0001056)1.81960611
134Pulmonary infiltrates (HP:0002113)1.81623074
135Restrictive lung disease (HP:0002091)1.81498345
136Gingivitis (HP:0000230)1.81290352
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80578737
138Personality changes (HP:0000751)1.79602886
139Seborrheic dermatitis (HP:0001051)1.78683070
140Onion bulb formation (HP:0003383)1.78204661
141Difficulty running (HP:0009046)1.78111415
142Urethral obstruction (HP:0000796)1.77860691
143Short nail (HP:0001799)1.77089626
144Polycythemia (HP:0001901)1.76803948
145Joint hemorrhage (HP:0005261)1.75982695
146Xanthomatosis (HP:0000991)1.75614718
147Abnormality of the sella turcica (HP:0002679)1.73424205
148Disinhibition (HP:0000734)1.73127096
149Verrucae (HP:0200043)1.72595940
150Papilloma (HP:0012740)1.72595940
151Recurrent fungal infections (HP:0002841)1.72559501
152Neuronal loss in central nervous system (HP:0002529)1.71859286
153Right ventricular cardiomyopathy (HP:0011663)1.71472891
154Ulnar deviation of the wrist (HP:0003049)1.71292115
155Agnosia (HP:0010524)1.71092154
156Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70937755
157Recurrent viral infections (HP:0004429)1.67698953
158Turricephaly (HP:0000262)1.65767548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.54915688
2ERN13.53237704
3PRPF4B3.35914317
4PKN22.98334065
5TGFBR22.96945144
6MAP4K12.87604975
7TRIB32.82291096
8CAMK1D2.71698008
9EEF2K2.64803561
10MET2.61909981
11BLK2.57970748
12DAPK22.36931370
13MAP3K102.31789707
14TAOK32.16315393
15BMX2.07087983
16FGFR42.06003512
17STK101.99988217
18GRK61.97716685
19RIPK11.94593078
20MAP3K111.81819531
21TNK21.81524974
22TYK21.78138750
23CAMK1G1.76376583
24SMG11.71345654
25PTK61.64648641
26MAP2K31.63438375
27MAP3K141.58773471
28CDC42BPA1.52353487
29MARK21.45870749
30CSF1R1.44571909
31ZAP701.38450151
32FES1.34135882
33EPHB11.32178453
34LMTK21.30875931
35EPHA21.26738102
36CLK11.19423638
37NEK21.19017685
38FGR1.18518579
39LRRK21.15957829
40TBK11.15563964
41EPHB21.14688297
42CSK1.13826853
43TAOK11.13604544
44SIK31.08638251
45SCYL21.07051588
46FGFR31.05613554
47RPS6KA41.05081630
48IKBKE1.02371561
49MAP2K60.97386272
50MAP3K70.97119308
51MAP2K20.96988485
52PRKD20.96538410
53DAPK10.96286879
54PAK40.96085506
55NME20.96063251
56RPS6KB20.91575459
57HCK0.91210907
58MAPK70.87865631
59TTN0.87398455
60KSR20.87097955
61BTK0.85457344
62SIK20.83405877
63MAPKAPK30.82296478
64ITK0.81801379
65KDR0.77291655
66HIPK20.74717294
67LCK0.74629689
68CDK120.74102870
69TYRO30.73500234
70PDGFRA0.72479943
71CDK40.71876999
72JAK20.71784480
73DYRK1B0.71348555
74TAOK20.69631769
75MATK0.69379522
76TGFBR10.67882721
77BCKDK0.67415285
78MAP3K130.66157964
79MTOR0.66069034
80CAMKK10.65993802
81JAK10.65365709
82PRKCH0.64969983
83MAP3K80.64326845
84RIPK40.62964718
85MAPK120.61564065
86RPS6KC10.61110492
87RPS6KL10.61110492
88RPS6KA20.60996233
89STK380.60001044
90RPS6KA60.58637281
91CDK60.56588112
92TXK0.56093294
93DDR20.55975220
94MAPK150.54550724
95MAP3K60.53752211
96MAPK110.53249976
97PRKG20.53027527
98SYK0.51392574
99SIK10.51377457
100PTK20.49863591
101MARK30.49268832
102IGF1R0.48683080
103IRAK20.46150812
104PDGFRB0.46040547
105EIF2AK10.45091144
106EGFR0.44589053
107PRKAA20.44309152
108TLK10.43546493
109MAP3K20.43356294
110NME10.42708187
111IRAK10.42481862
112IRAK40.41442126
113SGK30.39990535
114RET0.39961184
115IRAK30.39422164
116PIK3CG0.39164482
117FLT30.38896395
118KIT0.38349489
119MOS0.37847807
120DAPK30.37665432
121MAP3K10.37539279
122ICK0.36598257
123CHUK0.35720074
124EPHA30.35376109
125IKBKB0.34738098
126CAMK40.34173001
127MAP3K30.34155679
128PDK10.32982220
129LYN0.32370523
130JAK30.32294829
131FYN0.31224608
132ERBB20.30761860
133PDPK10.30390170

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051506.90263380
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.21941110
3* Other glycan degradation_Homo sapiens_hsa005113.83097879
4Complement and coagulation cascades_Homo sapiens_hsa046103.65606285
5Pertussis_Homo sapiens_hsa051332.66212652
6Caffeine metabolism_Homo sapiens_hsa002322.45035208
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25451556
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18951985
9Nitrogen metabolism_Homo sapiens_hsa009102.14902156
10Arachidonic acid metabolism_Homo sapiens_hsa005902.13133650
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.05011352
12Lysosome_Homo sapiens_hsa041422.01727838
13Sulfur relay system_Homo sapiens_hsa041221.96806115
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.94650170
15Linoleic acid metabolism_Homo sapiens_hsa005911.87746746
16Leishmaniasis_Homo sapiens_hsa051401.82418786
17Prion diseases_Homo sapiens_hsa050201.62789380
18Allograft rejection_Homo sapiens_hsa053301.57048893
19Graft-versus-host disease_Homo sapiens_hsa053321.48371996
20T cell receptor signaling pathway_Homo sapiens_hsa046601.44154024
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.41583574
22Autoimmune thyroid disease_Homo sapiens_hsa053201.40648521
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.36282977
24Ribosome_Homo sapiens_hsa030101.34709300
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32148040
26Non-small cell lung cancer_Homo sapiens_hsa052231.28921951
27TNF signaling pathway_Homo sapiens_hsa046681.28527158
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21086387
29Lysine degradation_Homo sapiens_hsa003101.20834632
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19335719
31Osteoclast differentiation_Homo sapiens_hsa043801.17896603
32Primary immunodeficiency_Homo sapiens_hsa053401.17611755
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.15515757
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14779268
35Malaria_Homo sapiens_hsa051441.14686014
36ABC transporters_Homo sapiens_hsa020101.14661885
37Viral myocarditis_Homo sapiens_hsa054161.11049160
38Measles_Homo sapiens_hsa051621.08488846
39GnRH signaling pathway_Homo sapiens_hsa049121.07865264
40Fructose and mannose metabolism_Homo sapiens_hsa000511.05467955
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.05121949
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.04165609
43Pentose phosphate pathway_Homo sapiens_hsa000301.02984895
44Legionellosis_Homo sapiens_hsa051341.00556066
45Choline metabolism in cancer_Homo sapiens_hsa052310.99326073
46Hepatitis B_Homo sapiens_hsa051610.98344888
47Selenocompound metabolism_Homo sapiens_hsa004500.97840255
48Asthma_Homo sapiens_hsa053100.96928565
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95219474
50Fatty acid degradation_Homo sapiens_hsa000710.92208268
51Type I diabetes mellitus_Homo sapiens_hsa049400.92123261
52Prolactin signaling pathway_Homo sapiens_hsa049170.89735967
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89226127
54B cell receptor signaling pathway_Homo sapiens_hsa046620.89179525
55mTOR signaling pathway_Homo sapiens_hsa041500.88907121
56Insulin signaling pathway_Homo sapiens_hsa049100.88386982
57Galactose metabolism_Homo sapiens_hsa000520.87930576
58Histidine metabolism_Homo sapiens_hsa003400.87859774
59Hematopoietic cell lineage_Homo sapiens_hsa046400.87510837
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86912129
61Folate biosynthesis_Homo sapiens_hsa007900.86557981
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86228415
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86134266
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.85909018
65Renal cell carcinoma_Homo sapiens_hsa052110.85446720
66Amoebiasis_Homo sapiens_hsa051460.84509995
67Fat digestion and absorption_Homo sapiens_hsa049750.84341994
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.83084233
69Toxoplasmosis_Homo sapiens_hsa051450.82719013
70Endometrial cancer_Homo sapiens_hsa052130.81314498
71Starch and sucrose metabolism_Homo sapiens_hsa005000.81011578
72Platelet activation_Homo sapiens_hsa046110.80569017
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79701352
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.79200152
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.78626784
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77489954
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74212098
78Inositol phosphate metabolism_Homo sapiens_hsa005620.73565563
79One carbon pool by folate_Homo sapiens_hsa006700.70678922
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69034403
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68227214
82Chemical carcinogenesis_Homo sapiens_hsa052040.68020237
83ErbB signaling pathway_Homo sapiens_hsa040120.67734049
84Systemic lupus erythematosus_Homo sapiens_hsa053220.67290100
85Arginine biosynthesis_Homo sapiens_hsa002200.67160719
86Chronic myeloid leukemia_Homo sapiens_hsa052200.66738934
87Notch signaling pathway_Homo sapiens_hsa043300.66181631
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65959128
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65837679
90African trypanosomiasis_Homo sapiens_hsa051430.65738866
91Estrogen signaling pathway_Homo sapiens_hsa049150.65728344
92Antigen processing and presentation_Homo sapiens_hsa046120.64177632
93Endocytosis_Homo sapiens_hsa041440.64129272
94Chemokine signaling pathway_Homo sapiens_hsa040620.62361484
95FoxO signaling pathway_Homo sapiens_hsa040680.62217544
96HIF-1 signaling pathway_Homo sapiens_hsa040660.62168940
97Tuberculosis_Homo sapiens_hsa051520.61937481
98HTLV-I infection_Homo sapiens_hsa051660.60177648
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59900747
100Acute myeloid leukemia_Homo sapiens_hsa052210.59519231
101Phagosome_Homo sapiens_hsa041450.59503228
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.59203593
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59153132
104N-Glycan biosynthesis_Homo sapiens_hsa005100.58941045
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55058791
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55005127
107AMPK signaling pathway_Homo sapiens_hsa041520.52881702
108Colorectal cancer_Homo sapiens_hsa052100.51409813
109MAPK signaling pathway_Homo sapiens_hsa040100.51233835
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51144584
111Bile secretion_Homo sapiens_hsa049760.49845426
112Biosynthesis of amino acids_Homo sapiens_hsa012300.49714600
113Glioma_Homo sapiens_hsa052140.49160720
114Small cell lung cancer_Homo sapiens_hsa052220.49077316
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48459744
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47790818
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47500179
118Prostate cancer_Homo sapiens_hsa052150.47497543
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47225667
120PPAR signaling pathway_Homo sapiens_hsa033200.47154088
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.47115629
122Viral carcinogenesis_Homo sapiens_hsa052030.44901540
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43936667
124Apoptosis_Homo sapiens_hsa042100.43095800
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42078424
126VEGF signaling pathway_Homo sapiens_hsa043700.42022026
127DNA replication_Homo sapiens_hsa030300.39403937
128Hepatitis C_Homo sapiens_hsa051600.39340069
129Salmonella infection_Homo sapiens_hsa051320.39170858
130Influenza A_Homo sapiens_hsa051640.38652689
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38110533
132beta-Alanine metabolism_Homo sapiens_hsa004100.36988329
133Proteoglycans in cancer_Homo sapiens_hsa052050.34597497
134Carbon metabolism_Homo sapiens_hsa012000.33146223
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31971916
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31647590
137Adherens junction_Homo sapiens_hsa045200.31548106
138Shigellosis_Homo sapiens_hsa051310.31362318
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31123518
140Glutathione metabolism_Homo sapiens_hsa004800.31096566
141Retinol metabolism_Homo sapiens_hsa008300.29192526
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.28969339
143Herpes simplex infection_Homo sapiens_hsa051680.28011315
144Tryptophan metabolism_Homo sapiens_hsa003800.27927774
145Insulin resistance_Homo sapiens_hsa049310.27589349
146Pancreatic cancer_Homo sapiens_hsa052120.26305496
147Thyroid cancer_Homo sapiens_hsa052160.25829158
148Pyruvate metabolism_Homo sapiens_hsa006200.25013627
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.23930514
150Bladder cancer_Homo sapiens_hsa052190.23874628
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23168322

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