ENKD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.13576402
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.07189124
3cilium or flagellum-dependent cell motility (GO:0001539)8.74597196
4cilium movement (GO:0003341)8.32609754
5epithelial cilium movement (GO:0003351)7.83678563
6left/right pattern formation (GO:0060972)6.93349183
7axoneme assembly (GO:0035082)6.02065564
8regulation of cilium movement (GO:0003352)5.73920478
9DNA strand elongation involved in DNA replication (GO:0006271)5.42100526
10DNA strand elongation (GO:0022616)5.17972014
11DNA unwinding involved in DNA replication (GO:0006268)5.14432734
12telomere maintenance via semi-conservative replication (GO:0032201)5.08176608
13DNA replication initiation (GO:0006270)5.01416148
14cell-cell junction maintenance (GO:0045217)4.89450542
15pattern specification involved in kidney development (GO:0061004)4.83656233
16DNA deamination (GO:0045006)4.72002789
17telomere maintenance via recombination (GO:0000722)4.53629584
18synaptonemal complex assembly (GO:0007130)4.49789359
19regulation of microtubule-based movement (GO:0060632)4.37063987
20mitotic recombination (GO:0006312)4.30724427
21DNA replication checkpoint (GO:0000076)4.29335654
22intraciliary transport (GO:0042073)4.26393773
23embryonic body morphogenesis (GO:0010172)4.22590316
24protein localization to kinetochore (GO:0034501)4.19903843
25microtubule bundle formation (GO:0001578)4.13496834
26camera-type eye morphogenesis (GO:0048593)4.07856929
27viral life cycle (GO:0019058)4.07353990
28DNA replication-dependent nucleosome assembly (GO:0006335)4.05202067
29DNA replication-dependent nucleosome organization (GO:0034723)4.05202067
30nucleotide-excision repair, DNA gap filling (GO:0006297)4.03488037
31telomere maintenance via telomere lengthening (GO:0010833)4.01301370
32protein localization to chromosome, centromeric region (GO:0071459)4.00608691
33ribosomal small subunit assembly (GO:0000028)3.99169644
34body morphogenesis (GO:0010171)3.93148604
35lung epithelium development (GO:0060428)3.90497995
36synaptonemal complex organization (GO:0070193)3.85813647
37translesion synthesis (GO:0019985)3.82879968
38cell junction maintenance (GO:0034331)3.78578911
39nucleobase biosynthetic process (GO:0046112)3.77216879
40formation of translation preinitiation complex (GO:0001731)3.75756819
41maturation of SSU-rRNA (GO:0030490)3.75509515
42left/right axis specification (GO:0070986)3.75414718
43chromatin remodeling at centromere (GO:0031055)3.69673500
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.65833540
45CENP-A containing nucleosome assembly (GO:0034080)3.64480615
46ventricular system development (GO:0021591)3.62390146
47establishment of integrated proviral latency (GO:0075713)3.61560863
48protein localization to endoplasmic reticulum (GO:0070972)3.59496072
49mitotic nuclear envelope disassembly (GO:0007077)3.58722528
50response to xenobiotic stimulus (GO:0009410)3.57214152
51viral transcription (GO:0019083)3.56874837
52establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56473764
53sperm capacitation (GO:0048240)3.55967871
54DNA replication-independent nucleosome assembly (GO:0006336)3.51940342
55DNA replication-independent nucleosome organization (GO:0034724)3.51940342
56translational termination (GO:0006415)3.51731461
57macromolecular complex disassembly (GO:0032984)3.51583908
58mitotic metaphase plate congression (GO:0007080)3.51322775
59cell proliferation in forebrain (GO:0021846)3.46028059
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45119723
61histone exchange (GO:0043486)3.42956961
62regulation of chromatin binding (GO:0035561)3.42905397
63chromosome organization involved in meiosis (GO:0070192)3.42094473
64protein insertion into membrane (GO:0051205)3.39395352
65postreplication repair (GO:0006301)3.39149534
66somatic hypermutation of immunoglobulin genes (GO:0016446)3.36450818
67somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36450818
68translational elongation (GO:0006414)3.36373174
69purine nucleobase biosynthetic process (GO:0009113)3.30468070
70membrane disassembly (GO:0030397)3.28270272
71nuclear envelope disassembly (GO:0051081)3.28270272
72primary alcohol catabolic process (GO:0034310)3.26766711
73IMP biosynthetic process (GO:0006188)3.26061606
74mitotic sister chromatid segregation (GO:0000070)3.24923297
75protein localization to cilium (GO:0061512)3.23788358
76cilium organization (GO:0044782)3.22766826
77nuclear pore organization (GO:0006999)3.22557956
78spliceosomal snRNP assembly (GO:0000387)3.22157737
79DNA duplex unwinding (GO:0032508)3.21294560
80negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20753403
81male meiosis I (GO:0007141)3.19141938
82DNA geometric change (GO:0032392)3.18993418
83cilium assembly (GO:0042384)3.18964132
84translational initiation (GO:0006413)3.18139536
85ribosomal small subunit biogenesis (GO:0042274)3.15514408
86nuclear pore complex assembly (GO:0051292)3.15321492
87kinetochore organization (GO:0051383)3.13940536
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.13913123
89metaphase plate congression (GO:0051310)3.13044087
90UV protection (GO:0009650)3.12866160
91folic acid-containing compound biosynthetic process (GO:0009396)3.12789187
92positive regulation of gastrulation (GO:2000543)3.11824622
93histone H2A acetylation (GO:0043968)3.11285703
94centriole assembly (GO:0098534)3.10557979
95telomere maintenance (GO:0000723)3.10060734
96telomere organization (GO:0032200)3.09395148
97mismatch repair (GO:0006298)3.08938095
98mitotic chromosome condensation (GO:0007076)3.06263263
99attachment of spindle microtubules to kinetochore (GO:0008608)3.05965127
100binding of sperm to zona pellucida (GO:0007339)3.05203514
101nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03341523
102base-excision repair (GO:0006284)3.03327164
103establishment of apical/basal cell polarity (GO:0035089)3.02173466
104ribosome biogenesis (GO:0042254)3.02079980
105negative regulation of T cell differentiation in thymus (GO:0033085)3.01374485
106regulation of centrosome cycle (GO:0046605)2.98440838
107membrane repolarization during action potential (GO:0086011)2.98187477
108intra-S DNA damage checkpoint (GO:0031573)2.98008848
109sister chromatid segregation (GO:0000819)2.97466161
110ribonucleoprotein complex biogenesis (GO:0022613)2.97427746
111SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97210179
112negative regulation of DNA-templated transcription, elongation (GO:0032785)2.96750473
113regulation of somitogenesis (GO:0014807)2.96739958
114regulation of nuclear cell cycle DNA replication (GO:0033262)2.96471956
115chromosome condensation (GO:0030261)2.96147615
116DNA conformation change (GO:0071103)2.95604870
117termination of RNA polymerase II transcription (GO:0006369)2.94404100
118chromatin assembly or disassembly (GO:0006333)2.94160290
119transcription-coupled nucleotide-excision repair (GO:0006283)2.93199940
120negative regulation of RNA splicing (GO:0033119)2.92574354
121negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.92539292
122protein localization to chromosome (GO:0034502)2.91073433
123ATP-dependent chromatin remodeling (GO:0043044)2.90573169
124rRNA processing (GO:0006364)2.90569452
125regulation of centriole replication (GO:0046599)2.89593421
126establishment of chromosome localization (GO:0051303)2.89142741
127establishment or maintenance of monopolar cell polarity (GO:0061339)2.88840498
128establishment of monopolar cell polarity (GO:0061162)2.88840498
129cotranslational protein targeting to membrane (GO:0006613)2.88351565
130DNA packaging (GO:0006323)2.88215299
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88156720
132regulation of chromosome segregation (GO:0051983)2.88083131
133sperm-egg recognition (GO:0035036)2.87907905
134cellular protein complex disassembly (GO:0043624)2.87740609
135segment specification (GO:0007379)2.87647940
136IMP metabolic process (GO:0046040)2.87418358
137protein targeting to ER (GO:0045047)2.86945785
138ribosomal large subunit biogenesis (GO:0042273)2.86074598
139diterpenoid biosynthetic process (GO:0016102)2.84847003
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84217922
141kinetochore assembly (GO:0051382)2.83860695
142spliceosomal complex assembly (GO:0000245)2.83614716
143negative regulation of chromosome segregation (GO:0051985)2.83374646
144rRNA metabolic process (GO:0016072)2.82400942
145protein complex disassembly (GO:0043241)2.81332824
146regulation of histone H3-K9 methylation (GO:0051570)2.81066344
147protein retention in ER lumen (GO:0006621)2.80832336
148axonemal dynein complex assembly (GO:0070286)2.80493848
149piRNA metabolic process (GO:0034587)2.79772284
150negative regulation of mitotic sister chromatid separation (GO:2000816)2.79732020
151negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79732020
152negative regulation of sister chromatid segregation (GO:0033046)2.79732020
153protein targeting to membrane (GO:0006612)2.79667495
154microtubule-based movement (GO:0007018)2.78830762
155membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78397320
156substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.70916856
157substrate-independent telencephalic tangential migration (GO:0021826)2.70916856
158negative regulation of catenin import into nucleus (GO:0035414)2.70341089
159embryonic camera-type eye development (GO:0031076)2.69880547
160renal system development (GO:0072001)2.68369680
161DNA synthesis involved in DNA repair (GO:0000731)2.68331869
162ethanol metabolic process (GO:0006067)2.67868676
163sulfation (GO:0051923)2.60214103
164synapsis (GO:0007129)2.57325723
165positive regulation of smoothened signaling pathway (GO:0045880)2.57126741
166neuron remodeling (GO:0016322)2.56365491
167DNA methylation involved in gamete generation (GO:0043046)2.56036196
168DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.52963585
169planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50813022
170microtubule severing (GO:0051013)2.47658464
171phenol-containing compound catabolic process (GO:0019336)2.45497191
172negative regulation of inclusion body assembly (GO:0090084)2.45122743
173establishment of planar polarity (GO:0001736)2.44515357
174establishment of tissue polarity (GO:0007164)2.44515357
175negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.42925886
176semaphorin-plexin signaling pathway (GO:0071526)2.42646680
177cytoplasmic microtubule organization (GO:0031122)2.41087515
178cellular component assembly involved in morphogenesis (GO:0010927)2.40272574
179maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39000454
180one-carbon compound transport (GO:0019755)2.37022027
181DNA damage response, signal transduction resulting in transcription (GO:0042772)2.36127522
182cilium morphogenesis (GO:0060271)2.35658486
183ear development (GO:0043583)2.35597594
184meiosis I (GO:0007127)2.33985181
185lung morphogenesis (GO:0060425)2.33029742
186sperm motility (GO:0030317)2.31574544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.17420168
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.00070320
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.99309323
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79314710
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71657318
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.70708067
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11476181
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88551715
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78729489
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.74441138
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74025709
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67755543
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66271593
14LXR_22292898_ChIP-Seq_THP-1_Human2.66256262
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60641495
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.55177681
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52737191
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.51949822
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.45597905
20XRN2_22483619_ChIP-Seq_HELA_Human2.31928645
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29634752
22P68_20966046_ChIP-Seq_HELA_Human2.18769423
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17039519
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.14937812
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08722258
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06457857
27VDR_23849224_ChIP-Seq_CD4+_Human2.03035358
28TET1_21451524_ChIP-Seq_MESCs_Mouse2.01848942
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00030277
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97869519
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.97834969
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97047381
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.96865814
34SMC4_20622854_ChIP-Seq_HELA_Human1.95642629
35AR_21909140_ChIP-Seq_LNCAP_Human1.94708152
36RACK7_27058665_Chip-Seq_MCF-7_Human1.92533113
37CTCF_27219007_Chip-Seq_Bcells_Human1.92165433
38FOXP3_21729870_ChIP-Seq_TREG_Human1.91296682
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88816849
40DCP1A_22483619_ChIP-Seq_HELA_Human1.88505953
41GABP_19822575_ChIP-Seq_HepG2_Human1.86841522
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85008607
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84205949
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83051186
45MYC_22102868_ChIP-Seq_BL_Human1.82100872
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81666422
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81352698
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80562303
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79527151
50EZH2_22144423_ChIP-Seq_EOC_Human1.78493042
51TTF2_22483619_ChIP-Seq_HELA_Human1.75319736
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74646769
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73365725
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72817669
55CIITA_25753668_ChIP-Seq_RAJI_Human1.70706170
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70223397
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.69504085
58KDM2B_26808549_Chip-Seq_K562_Human1.68331788
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.68076935
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64378281
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64206995
62CREB1_26743006_Chip-Seq_LNCaP_Human1.63844679
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.62256061
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61680058
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61578048
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.60204415
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59838309
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58957079
69ZNF263_19887448_ChIP-Seq_K562_Human1.57602536
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57164205
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.55343759
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55330738
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53511444
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53312926
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52023685
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51659517
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51478465
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.51215058
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49126967
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.48081911
81BCL6_27268052_Chip-Seq_Bcells_Human1.47910548
82PHF8_20622854_ChIP-Seq_HELA_Human1.47852616
83BCOR_27268052_Chip-Seq_Bcells_Human1.45739033
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.44148091
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.43824950
86KDM2B_26808549_Chip-Seq_DND41_Human1.43472424
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42769879
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42473592
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41492989
90KDM5A_27292631_Chip-Seq_BREAST_Human1.39850509
91VDR_21846776_ChIP-Seq_THP-1_Human1.39536686
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38735455
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38487042
94E2F1_20622854_ChIP-Seq_HELA_Human1.37516458
95SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36687776
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34794334
97DROSHA_22980978_ChIP-Seq_HELA_Human1.33993870
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.33958984
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32557666
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31452648
101TP53_22127205_ChIP-Seq_IMR90_Human1.31159375
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30801086
103MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.30688951
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.30647961
105RARA_24833708_ChIP-Seq_LIVER_Mouse1.30176908
106SRF_21415370_ChIP-Seq_HL-1_Mouse1.29186787
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28265403
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27982108
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27626932
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.27372354
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27247245
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26873831
113CTCF_20526341_ChIP-Seq_ESCs_Human1.26412473
114ELK1_19687146_ChIP-ChIP_HELA_Human1.25842901
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25610416
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25093379
117SA1_27219007_Chip-Seq_Bcells_Human1.24915725
118TP63_22573176_ChIP-Seq_HFKS_Human1.24796567
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24308478
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23338406
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22543384
122ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21905872
123DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21623312
124RNF2_27304074_Chip-Seq_ESCs_Mouse1.18870017
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18584299
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16993466
127KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16845705
128RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15153464
129EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15153464
130STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.14645388
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13749350
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.12608775
133SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10829599
134SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10486403
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10260708
136RUNX1_27514584_Chip-Seq_MCF-7_Human1.10061497
137OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08410832
138KDM2B_26808549_Chip-Seq_JURKAT_Human1.08328635
139TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08275438
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07112074
141TET1_21490601_ChIP-Seq_MESCs_Mouse1.06331729
142SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05468696
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05147376
144SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04743582
145OCT4_19829295_ChIP-Seq_ESCs_Human1.04524882
146STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04507774
147STAT1_20625510_ChIP-Seq_HELA_Human1.04500922
148EZH2_27304074_Chip-Seq_ESCs_Mouse1.04268727
149NOTCH1_21737748_ChIP-Seq_TLL_Human1.03671000
150PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03568656
151CTCF_21964334_Chip-Seq_Bcells_Human1.03421030
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02601951
153POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02222193
154SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02069061
155RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00527287
156TFEB_21752829_ChIP-Seq_HELA_Human1.00323593
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.99259812
158CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98744222
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97405627
160KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97343788
161RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97339404
162CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97044735
163TP53_23651856_ChIP-Seq_MEFs_Mouse0.96553538
164PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96501516
165JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96285659
166RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95772512
167MAF_26560356_Chip-Seq_TH2_Human0.94799696
168DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94716862
169KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93218025
170CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91747215
171CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90703776
172POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89961809
173SPI1_23547873_ChIP-Seq_NB4_Human0.88969643
174PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88727271
175RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86895495
176HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85638738
177NANOG_21062744_ChIP-ChIP_HESCs_Human0.82562804
178MYC_18940864_ChIP-ChIP_HL60_Human0.81968253
179ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78005630
180YY1_22570637_ChIP-Seq_MALME-3M_Human0.77469528
181SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76389547
182FOXP1_21924763_ChIP-Seq_HESCs_Human0.76306285
183CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74789128
184GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73364667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.92769986
2MP0010094_abnormal_chromosome_stability4.87740754
3MP0003111_abnormal_nucleus_morphology4.42933130
4MP0003077_abnormal_cell_cycle3.99647958
5MP0004957_abnormal_blastocyst_morpholog3.96863025
6MP0008057_abnormal_DNA_replication3.89537531
7MP0008058_abnormal_DNA_repair3.76044252
8MP0008877_abnormal_DNA_methylation2.94678316
9MP0002249_abnormal_larynx_morphology2.85724252
10MP0008007_abnormal_cellular_replicative2.84852245
11MP0005410_abnormal_fertilization2.80070627
12MP0000678_abnormal_parathyroid_gland2.75119434
13MP0008932_abnormal_embryonic_tissue2.59789715
14MP0002396_abnormal_hematopoietic_system2.56947736
15MP0000566_synostosis2.30621390
16MP0001730_embryonic_growth_arrest2.25429556
17MP0003878_abnormal_ear_physiology2.15169162
18MP0005377_hearing/vestibular/ear_phenot2.15169162
19MP0000350_abnormal_cell_proliferation2.11746148
20MP0001502_abnormal_circadian_rhythm2.10659695
21MP0008875_abnormal_xenobiotic_pharmacok2.08058596
22MP0004808_abnormal_hematopoietic_stem2.05049684
23MP0001929_abnormal_gametogenesis2.02643464
24MP0005083_abnormal_biliary_tract1.97045918
25MP0003786_premature_aging1.93035279
26MP0002210_abnormal_sex_determination1.89862153
27MP0005409_darkened_coat_color1.88961077
28MP0010352_gastrointestinal_tract_polyps1.88547081
29MP0003123_paternal_imprinting1.87543554
30MP0010307_abnormal_tumor_latency1.86079004
31MP0003879_abnormal_hair_cell1.85849396
32MP0000490_abnormal_crypts_of1.74664396
33MP0001485_abnormal_pinna_reflex1.72357300
34MP0002163_abnormal_gland_morphology1.72027565
35MP0000681_abnormal_thyroid_gland1.69098096
36MP0001545_abnormal_hematopoietic_system1.68727397
37MP0005397_hematopoietic_system_phenotyp1.68727397
38MP0001145_abnormal_male_reproductive1.65440147
39MP0002160_abnormal_reproductive_system1.65374156
40MP0001697_abnormal_embryo_size1.65233267
41MP0003698_abnormal_male_reproductive1.63426746
42MP0002653_abnormal_ependyma_morphology1.60722720
43MP0001348_abnormal_lacrimal_gland1.59223423
44MP0000313_abnormal_cell_death1.58962764
45MP0005623_abnormal_meninges_morphology1.57323633
46MP0002080_prenatal_lethality1.55460107
47MP0002116_abnormal_craniofacial_bone1.54790190
48MP0005058_abnormal_lysosome_morphology1.53856055
49MP0010030_abnormal_orbit_morphology1.51370174
50MP0002019_abnormal_tumor_incidence1.51360420
51MP0005380_embryogenesis_phenotype1.50346634
52MP0001672_abnormal_embryogenesis/_devel1.50346634
53MP0000778_abnormal_nervous_system1.48211920
54MP0002085_abnormal_embryonic_tissue1.47484145
55MP0009250_abnormal_appendicular_skeleto1.40195187
56MP0004133_heterotaxia1.38549054
57MP0001293_anophthalmia1.37353568
58MP0002084_abnormal_developmental_patter1.36114298
59MP0000653_abnormal_sex_gland1.35948577
60MP0003984_embryonic_growth_retardation1.35492001
61MP0002282_abnormal_trachea_morphology1.35458589
62MP0000026_abnormal_inner_ear1.33631751
63MP0002088_abnormal_embryonic_growth/wei1.30543044
64MP0000703_abnormal_thymus_morphology1.30430998
65MP0003763_abnormal_thymus_physiology1.29757757
66MP0009333_abnormal_splenocyte_physiolog1.28015336
67MP0001346_abnormal_lacrimal_gland1.26696941
68MP0001529_abnormal_vocalization1.25752433
69MP0003136_yellow_coat_color1.25219499
70MP0001849_ear_inflammation1.24298813
71MP0002735_abnormal_chemical_nociception1.22078038
72MP0004197_abnormal_fetal_growth/weight/1.20583042
73MP0002398_abnormal_bone_marrow1.18375480
74MP0002089_abnormal_postnatal_growth/wei1.17407942
75MP0003121_genomic_imprinting1.17308840
76MP0002132_abnormal_respiratory_system1.16632473
77MP0004859_abnormal_synaptic_plasticity1.16310462
78MP0000631_abnormal_neuroendocrine_gland1.14551284
79MP0000358_abnormal_cell_content/1.11789771
80MP0002086_abnormal_extraembryonic_tissu1.11418795
81MP0002722_abnormal_immune_system1.08680654
82MP0005503_abnormal_tendon_morphology1.08406191
83MP0002928_abnormal_bile_duct1.05041054
84MP0000689_abnormal_spleen_morphology1.04773779
85MP0000534_abnormal_ureter_morphology1.04662580
86MP0000955_abnormal_spinal_cord1.03771646
87MP0006054_spinal_hemorrhage1.03642009
88MP0002161_abnormal_fertility/fecundity1.03470255
89MP0005423_abnormal_somatic_nervous1.02993395
90MP0004742_abnormal_vestibular_system1.01667304
91MP0001905_abnormal_dopamine_level1.01277869
92MP0005257_abnormal_intraocular_pressure1.00980309
93MP0003938_abnormal_ear_development0.99511812
94MP0005174_abnormal_tail_pigmentation0.98774830
95MP0009278_abnormal_bone_marrow0.98353273
96MP0005389_reproductive_system_phenotype0.98167007
97MP0002152_abnormal_brain_morphology0.97687788
98MP0001984_abnormal_olfaction0.96104555
99MP0003890_abnormal_embryonic-extraembry0.96045185
100MP0006292_abnormal_olfactory_placode0.95072217
101MP0000163_abnormal_cartilage_morphology0.93347193
102MP0002882_abnormal_neuron_morphology0.92497617
103MP0005508_abnormal_skeleton_morphology0.92307804
104MP0004019_abnormal_vitamin_homeostasis0.91467730
105MP0000428_abnormal_craniofacial_morphol0.91006520
106MP0001970_abnormal_pain_threshold0.89248867
107MP0002429_abnormal_blood_cell0.88032437
108MP0003567_abnormal_fetal_cardiomyocyte0.86282941
109MP0002876_abnormal_thyroid_physiology0.86169880
110MP0003385_abnormal_body_wall0.85396464
111MP0001963_abnormal_hearing_physiology0.83816828
112MP0005076_abnormal_cell_differentiation0.82846385
113MP0003119_abnormal_digestive_system0.82145356
114MP0004233_abnormal_muscle_weight0.81339027
115MP0009672_abnormal_birth_weight0.80449741
116MP0002063_abnormal_learning/memory/cond0.80084985
117MP0008789_abnormal_olfactory_epithelium0.79359622
118MP0000858_altered_metastatic_potential0.79274959
119MP0000685_abnormal_immune_system0.78444706
120MP0003937_abnormal_limbs/digits/tail_de0.78261049
121MP0002272_abnormal_nervous_system0.78048919
122MP0002734_abnormal_mechanical_nocicepti0.77651762
123MP0005384_cellular_phenotype0.77576626
124MP0002277_abnormal_respiratory_mucosa0.76759010
125MP0003718_maternal_effect0.76575973
126MP0003635_abnormal_synaptic_transmissio0.75395060
127MP0006035_abnormal_mitochondrial_morpho0.75317426
128MP0002752_abnormal_somatic_nervous0.75108119
129MP0002233_abnormal_nose_morphology0.74882496
130MP0000537_abnormal_urethra_morphology0.74373324
131MP0001853_heart_inflammation0.74082274
132MP0002114_abnormal_axial_skeleton0.73562490
133MP0000716_abnormal_immune_system0.72996545
134MP0002234_abnormal_pharynx_morphology0.72964145
135MP0001270_distended_abdomen0.72745824
136MP0001119_abnormal_female_reproductive0.72162636
137MP0000049_abnormal_middle_ear0.71880549
138MP0002111_abnormal_tail_morphology0.70438502
139MP0003755_abnormal_palate_morphology0.68318155
140MP0002113_abnormal_skeleton_development0.67764555
141MP0001188_hyperpigmentation0.67493834
142MP0002095_abnormal_skin_pigmentation0.67455627
143MP0004142_abnormal_muscle_tone0.65318131
144MP0003315_abnormal_perineum_morphology0.64228894
145MP0000477_abnormal_intestine_morphology0.64226412
146MP0009053_abnormal_anal_canal0.64091396
147MP0002102_abnormal_ear_morphology0.63781448
148MP0005621_abnormal_cell_physiology0.63469945
149MP0003115_abnormal_respiratory_system0.63126937
150MP0005195_abnormal_posterior_eye0.62900946
151MP0001440_abnormal_grooming_behavior0.62674631
152MP0009379_abnormal_foot_pigmentation0.61742699
153MP0002733_abnormal_thermal_nociception0.61034550
154MP0000747_muscle_weakness0.60849323
155MP0002572_abnormal_emotion/affect_behav0.60530433
156MP0002405_respiratory_system_inflammati0.59815767
157MP0003221_abnormal_cardiomyocyte_apopto0.59269414
158MP0006036_abnormal_mitochondrial_physio0.59085967
159MP0002822_catalepsy0.59036916
160MP0003942_abnormal_urinary_system0.58855170
161MP0004885_abnormal_endolymph0.58662548
162MP0006276_abnormal_autonomic_nervous0.58644440
163MP0005499_abnormal_olfactory_system0.58620319
164MP0005394_taste/olfaction_phenotype0.58620319
165MP0006072_abnormal_retinal_apoptosis0.58444976
166MP0002092_abnormal_eye_morphology0.58364873
167MP0002067_abnormal_sensory_capabilities0.58135527
168MP0008995_early_reproductive_senescence0.57472365
169MP0003861_abnormal_nervous_system0.57082121
170MP0009703_decreased_birth_body0.56282781
171MP0002075_abnormal_coat/hair_pigmentati0.56268360
172MP0001915_intracranial_hemorrhage0.55404006
173MP0002932_abnormal_joint_morphology0.54527188

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.28707987
2Birth length less than 3rd percentile (HP:0003561)4.08095041
3Abnormality of cells of the erythroid lineage (HP:0012130)4.03650612
4Reticulocytopenia (HP:0001896)3.98388921
5Abnormal number of erythroid precursors (HP:0012131)3.95711957
6Infertility (HP:0000789)3.84769278
7Male infertility (HP:0003251)3.72954426
8Chromsome breakage (HP:0040012)3.59480692
9Atelectasis (HP:0100750)3.48941455
10Selective tooth agenesis (HP:0001592)3.48461801
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46727787
12Occipital encephalocele (HP:0002085)3.44500793
13Aplastic anemia (HP:0001915)3.43126051
14Meckel diverticulum (HP:0002245)3.37518461
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.27331469
16Abnormality of chromosome stability (HP:0003220)3.25095519
17Abnormality of the ileum (HP:0001549)3.23647849
18Breast hypoplasia (HP:0003187)3.21574400
19Abnormality of the preputium (HP:0100587)3.18703921
20Broad distal phalanx of finger (HP:0009836)3.17106808
21Medulloblastoma (HP:0002885)3.16487769
22Short femoral neck (HP:0100864)3.14437199
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.10769936
24Absent/shortened dynein arms (HP:0200106)3.10769936
25Abnormal respiratory epithelium morphology (HP:0012253)3.10753912
26Abnormal respiratory motile cilium morphology (HP:0005938)3.10753912
27Ependymoma (HP:0002888)3.10632769
28Cystic liver disease (HP:0006706)3.04871059
29Oral leukoplakia (HP:0002745)3.04429417
30Short nail (HP:0001799)2.93747917
3111 pairs of ribs (HP:0000878)2.90587550
32Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.87811040
33Chronic bronchitis (HP:0004469)2.85389986
34Abnormality of the anterior horn cell (HP:0006802)2.84783346
35Degeneration of anterior horn cells (HP:0002398)2.84783346
36Absent thumb (HP:0009777)2.80689648
37Colon cancer (HP:0003003)2.77599205
38Abnormal respiratory motile cilium physiology (HP:0012261)2.73245749
39Rhinitis (HP:0012384)2.73236945
40Duodenal stenosis (HP:0100867)2.72720682
41Small intestinal stenosis (HP:0012848)2.72720682
42Bell-shaped thorax (HP:0001591)2.72551108
43Patellar aplasia (HP:0006443)2.65951312
44Sloping forehead (HP:0000340)2.64915564
45Abnormality of the carotid arteries (HP:0005344)2.60291937
46Anomalous pulmonary venous return (HP:0010772)2.58963440
47Abnormal number of incisors (HP:0011064)2.56629093
48Pallor (HP:0000980)2.55841537
49Bone marrow hypocellularity (HP:0005528)2.54300454
50Recurrent otitis media (HP:0000403)2.52973573
51Supernumerary spleens (HP:0009799)2.52095621
52Nasal polyposis (HP:0100582)2.50020438
53Myelodysplasia (HP:0002863)2.49334720
54Rough bone trabeculation (HP:0100670)2.47425460
55Aplasia/Hypoplasia of the patella (HP:0006498)2.46746724
56Microretrognathia (HP:0000308)2.42622039
57Agnosia (HP:0010524)2.40222518
58Carpal bone hypoplasia (HP:0001498)2.38511529
59Impulsivity (HP:0100710)2.38422895
60Macrocytic anemia (HP:0001972)2.36561431
61Thrombocytosis (HP:0001894)2.30402356
62Chronic sinusitis (HP:0011109)2.28857726
63Increased nuchal translucency (HP:0010880)2.28135133
64Obstructive sleep apnea (HP:0002870)2.28005375
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27342065
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26845696
67Neoplasm of the pancreas (HP:0002894)2.25730341
68Bronchitis (HP:0012387)2.22927678
69Tracheoesophageal fistula (HP:0002575)2.22368113
70Pancreatic fibrosis (HP:0100732)2.22033059
71Asplenia (HP:0001746)2.21996970
72Abnormality of the pulmonary veins (HP:0011718)2.21828315
73Basal cell carcinoma (HP:0002671)2.20304968
74Postaxial foot polydactyly (HP:0001830)2.18403899
75Abnormality of DNA repair (HP:0003254)2.18194389
76Abnormality of the duodenum (HP:0002246)2.17391487
77Rhabdomyosarcoma (HP:0002859)2.16621065
78Pancreatic cysts (HP:0001737)2.13987763
79Sclerocornea (HP:0000647)2.13216985
80Recurrent sinusitis (HP:0011108)2.12781927
81Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11929120
82Aplasia/hypoplasia of the femur (HP:0005613)2.08839537
83Abdominal situs inversus (HP:0003363)2.08682511
84Abnormality of abdominal situs (HP:0011620)2.08682511
85Clubbing of toes (HP:0100760)2.07372385
86Renal duplication (HP:0000075)2.07297860
87Hand muscle atrophy (HP:0009130)2.07206872
88High pitched voice (HP:0001620)2.07060979
89Triphalangeal thumb (HP:0001199)2.06978407
90Abnormality of the aortic arch (HP:0012303)2.05008301
91Missing ribs (HP:0000921)2.04121995
92Optic nerve coloboma (HP:0000588)2.03841550
93Turricephaly (HP:0000262)2.03281008
94Poikiloderma (HP:0001029)2.02674028
95Cerebral hypomyelination (HP:0006808)2.02270080
96Aplasia/Hypoplasia of the spleen (HP:0010451)2.02041640
97Abnormality of midbrain morphology (HP:0002418)1.99501144
98Molar tooth sign on MRI (HP:0002419)1.99501144
99Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.99067392
100Hyperacusis (HP:0010780)1.96533625
101Nephronophthisis (HP:0000090)1.96128359
102True hermaphroditism (HP:0010459)1.96119442
103Pancytopenia (HP:0001876)1.96053037
104Atresia of the external auditory canal (HP:0000413)1.95691583
105Abnormality of dentin (HP:0010299)1.95269594
106Premature graying of hair (HP:0002216)1.95209635
107Abnormality of the nasal mucosa (HP:0000433)1.94879996
108Ectopic kidney (HP:0000086)1.93305145
109Severe visual impairment (HP:0001141)1.92749251
110Squamous cell carcinoma (HP:0002860)1.89458850
111Anencephaly (HP:0002323)1.88495796
112Abnormality of the astrocytes (HP:0100707)1.87190118
113Astrocytoma (HP:0009592)1.87190118
114Trismus (HP:0000211)1.85397744
115Bronchiectasis (HP:0002110)1.84809866
116Facial cleft (HP:0002006)1.84010851
117Abnormal ciliary motility (HP:0012262)1.82308452
118Premature ovarian failure (HP:0008209)1.82230436
119Neoplasm of striated muscle (HP:0009728)1.81782823
120Prominent nose (HP:0000448)1.81392154
121Recurrent bronchitis (HP:0002837)1.81286139
122Hyperthyroidism (HP:0000836)1.80783152
123Slender long bone (HP:0003100)1.80652562
124Abnormal lung lobation (HP:0002101)1.80290031
125Congenital hepatic fibrosis (HP:0002612)1.80123556
126Distal upper limb amyotrophy (HP:0007149)1.78099191
127Upper limb amyotrophy (HP:0009129)1.78099191
128Acute lymphatic leukemia (HP:0006721)1.76301268
129Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75705815
130Tubulointerstitial nephritis (HP:0001970)1.75573805
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.72428771
132Abnormality of the intervertebral disk (HP:0005108)1.68356095
133Abnormality of the middle phalanges of the toes (HP:0010183)1.65146342
134Medial flaring of the eyebrow (HP:0010747)1.64740832
135Flattened epiphyses (HP:0003071)1.63731256
136Abnormal rod and cone electroretinograms (HP:0008323)1.63346552
137Abnormality of the renal medulla (HP:0100957)1.61873726
138Gait imbalance (HP:0002141)1.61478532
139Congenital primary aphakia (HP:0007707)1.60268338
140Aortic regurgitation (HP:0001659)1.56692417
141Bowed forearm bones (HP:0003956)1.56185251
142Bowing of the arm (HP:0006488)1.56185251
143Male pseudohermaphroditism (HP:0000037)1.55797617
144Down-sloping shoulders (HP:0200021)1.54898614
145Chronic hepatic failure (HP:0100626)1.54553010
146Rib fusion (HP:0000902)1.53000488
147Preaxial hand polydactyly (HP:0001177)1.51550078
148Nephrogenic diabetes insipidus (HP:0009806)1.47032128
149Abnormality of the distal phalanges of the toes (HP:0010182)1.46179437
150Meningocele (HP:0002435)1.45383210
151Myelomeningocele (HP:0002475)1.45316746
152Holoprosencephaly (HP:0001360)1.44189049
153Partial duplication of the phalanx of hand (HP:0009999)1.40395764
154Postaxial hand polydactyly (HP:0001162)1.40249104
155Sleep apnea (HP:0010535)1.38626743
156Abnormality of the proximal phalanges of the hand (HP:0009834)1.38233557
157Myokymia (HP:0002411)1.37672794
158Hypoplastic pelvis (HP:0008839)1.37475333
159Cervical subluxation (HP:0003308)1.36913092
160Partial duplication of thumb phalanx (HP:0009944)1.36143869
161Retinitis pigmentosa (HP:0000510)1.34220131
162Short thorax (HP:0010306)1.30167071
163Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.29778190
164Truncus arteriosus (HP:0001660)1.27756837
165Hypercortisolism (HP:0001578)1.26447116
166Multiple lipomas (HP:0001012)1.26120928
167Coronal craniosynostosis (HP:0004440)1.25826787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.73580738
2CDC74.57739115
3WEE14.18033882
4BUB14.00290512
5SIK23.96597155
6NEK23.41160284
7STK162.66039984
8EPHA22.65210090
9SMG12.44138792
10PLK42.36972439
11CDK192.29228440
12TESK12.24253708
13TTK2.18432668
14NEK12.18149014
15ERN12.16284241
16MARK22.10690578
17SIK12.09924333
18EEF2K2.09710705
19PASK2.03783018
20TESK22.01860475
21ACVR1B2.00740061
22BRSK21.93431197
23PLK11.93396050
24ATR1.90276814
25PDK41.85488558
26PDK31.85488558
27ARAF1.84255115
28CCNB11.83932062
29PRKD21.80951629
30EIF2AK11.80106261
31SRPK11.79813346
32VRK11.79314953
33CDK71.77528028
34BRSK11.69276783
35NME21.66300343
36DYRK31.55525147
37MAP3K101.55336137
38AURKB1.54619909
39TLK11.44831102
40CHEK21.44120128
41RPS6KA41.41602422
42MAP3K61.39223665
43CDK41.38774215
44RIPK11.33492416
45MKNK11.33481754
46ABL21.33421955
47RPS6KB21.31212092
48TSSK61.31031200
49AURKA1.30398137
50EPHB21.26639752
51EIF2AK31.23424396
52SCYL21.22826443
53RPS6KL11.22534787
54RPS6KC11.22534787
55CHEK11.21962858
56STK101.17795031
57DDR21.16503849
58RPS6KA21.16246775
59MAP4K11.12551308
60MAP3K81.11543017
61PIM21.09029284
62MAP2K41.08751358
63STK41.08442855
64IRAK31.05311801
65FLT31.02901226
66HIPK21.01228541
67PKN21.00911945
68PLK31.00635391
69STK381.00124227
70PAK40.97874266
71LRRK20.96522109
72CDK80.94544991
73TRIB30.91139830
74TYRO30.89145953
75NTRK10.88756278
76TGFBR10.88689847
77CAMKK10.85388196
78BTK0.85214621
79LMTK20.84798511
80SGK2230.84545198
81SGK4940.84545198
82MAP3K90.84103783
83KIT0.84052535
84PAK10.83557442
85MAP3K110.82655014
86MAP3K70.81366020
87CDK120.80433601
88ATM0.80038512
89CDK20.79995432
90MAP2K70.79940796
91MKNK20.78332804
92PDPK10.77871772
93BRAF0.77382796
94KDR0.75783661
95PIM10.74240768
96TBK10.73908809
97IRAK20.73367664
98ICK0.71085105
99DAPK30.70056912
100MST1R0.69557681
101BMX0.68404442
102PTK20.67051325
103PDK20.66595420
104DYRK20.65370050
105MAP3K30.62999636
106CSNK2A10.62736743
107CLK10.62024888
108PTK2B0.61435551
109MAP2K30.60873619
110PTK60.60392464
111MAPKAPK30.60343823
112STK110.60112359
113CSNK2A20.59750996
114PRPF4B0.59269074
115ZAK0.55554629
116CDK10.54154392
117ZAP700.54046311
118CDK60.53730020
119CDK90.52439655
120NTRK30.51943679
121PRKCH0.50565476
122GRK60.50079907
123ILK0.49881443
124DMPK0.48958780
125MAP3K10.48675432
126NME10.48553682
127MAP2K20.47691875
128BRD40.47416621
129CDC42BPA0.46961552
130RPS6KA50.46157967
131DAPK10.45782681
132CAMK2G0.45662862
133PRKD30.45462296
134CSK0.44628599
135CSF1R0.43326240
136BCKDK0.42580467
137BLK0.42443814
138AKT10.42172069
139CAMK10.42052987
140SGK30.41907655
141CAMK1G0.41391020
142MAP2K60.41300249
143PNCK0.41189996
144MAPK110.40100830
145DYRK1B0.39763055
146MAPK120.39121147
147AKT20.38986032
148MOS0.38895822
149TAOK20.38486738
150PRKCI0.37213466
151PRKCZ0.36560822
152TEC0.36106245
153MAPK70.34986746
154PDGFRB0.34245361
155YES10.34060764
156ERBB20.33728141
157MTOR0.33676235
158PBK0.31640528
159TYK20.30931470
160PAK20.30850603
161MAPKAPK20.30835453
162RPS6KA60.30436927
163TAOK10.30329701
164PRKDC0.29958647
165CDK11A0.29399239

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.75878329
2Mismatch repair_Homo sapiens_hsa034304.86251343
3Base excision repair_Homo sapiens_hsa034103.44623601
4Phenylalanine metabolism_Homo sapiens_hsa003603.41247653
5Homologous recombination_Homo sapiens_hsa034403.35476170
6Ribosome_Homo sapiens_hsa030103.26936215
7Spliceosome_Homo sapiens_hsa030403.21883016
8Nucleotide excision repair_Homo sapiens_hsa034203.01983750
9RNA transport_Homo sapiens_hsa030132.89135610
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85529043
11Cell cycle_Homo sapiens_hsa041102.77217849
12Proteasome_Homo sapiens_hsa030502.74754435
13Fanconi anemia pathway_Homo sapiens_hsa034602.67128048
14RNA polymerase_Homo sapiens_hsa030202.66415527
15Pyrimidine metabolism_Homo sapiens_hsa002402.59202390
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.45363960
17One carbon pool by folate_Homo sapiens_hsa006702.43277718
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38525353
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.29506267
20Tyrosine metabolism_Homo sapiens_hsa003502.24059020
21Non-homologous end-joining_Homo sapiens_hsa034502.20079308
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05970193
23Glycosaminoglycan degradation_Homo sapiens_hsa005312.05390238
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96564982
25Basal transcription factors_Homo sapiens_hsa030221.75784265
26RNA degradation_Homo sapiens_hsa030181.75286146
27mRNA surveillance pathway_Homo sapiens_hsa030151.72440976
28p53 signaling pathway_Homo sapiens_hsa041151.55273937
29Cardiac muscle contraction_Homo sapiens_hsa042601.51512039
30Purine metabolism_Homo sapiens_hsa002301.49572532
31Chemical carcinogenesis_Homo sapiens_hsa052041.41547101
32Histidine metabolism_Homo sapiens_hsa003401.37603595
33Oxidative phosphorylation_Homo sapiens_hsa001901.32562344
34Synaptic vesicle cycle_Homo sapiens_hsa047211.30460284
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27827155
36Pentose phosphate pathway_Homo sapiens_hsa000301.27626943
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23245820
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14849164
39Systemic lupus erythematosus_Homo sapiens_hsa053221.14179599
40beta-Alanine metabolism_Homo sapiens_hsa004101.13600511
41Axon guidance_Homo sapiens_hsa043601.09894912
42Epstein-Barr virus infection_Homo sapiens_hsa051691.03531669
43Oocyte meiosis_Homo sapiens_hsa041141.03275137
44Biosynthesis of amino acids_Homo sapiens_hsa012301.03192446
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00627676
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97832074
47Viral carcinogenesis_Homo sapiens_hsa052030.94812441
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94650158
49Antigen processing and presentation_Homo sapiens_hsa046120.93823789
50Sulfur relay system_Homo sapiens_hsa041220.91421507
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88332015
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87627252
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85294947
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.83910227
55Alzheimers disease_Homo sapiens_hsa050100.83689266
56Herpes simplex infection_Homo sapiens_hsa051680.83561651
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80405006
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.78791759
59HTLV-I infection_Homo sapiens_hsa051660.77777356
60Prion diseases_Homo sapiens_hsa050200.75301512
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74691274
62Melanogenesis_Homo sapiens_hsa049160.73460170
63VEGF signaling pathway_Homo sapiens_hsa043700.73011506
64Selenocompound metabolism_Homo sapiens_hsa004500.71421893
65Huntingtons disease_Homo sapiens_hsa050160.69673003
66Primary immunodeficiency_Homo sapiens_hsa053400.68691865
67Nicotine addiction_Homo sapiens_hsa050330.66564432
68ABC transporters_Homo sapiens_hsa020100.65289086
69Endocytosis_Homo sapiens_hsa041440.64785115
70Fructose and mannose metabolism_Homo sapiens_hsa000510.64559153
71N-Glycan biosynthesis_Homo sapiens_hsa005100.64020272
72Carbon metabolism_Homo sapiens_hsa012000.62753940
73Cholinergic synapse_Homo sapiens_hsa047250.62718431
74Melanoma_Homo sapiens_hsa052180.61860137
75Other glycan degradation_Homo sapiens_hsa005110.60945905
76Lysosome_Homo sapiens_hsa041420.60051751
77Alcoholism_Homo sapiens_hsa050340.58308251
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56873825
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.52787324
80Legionellosis_Homo sapiens_hsa051340.52747136
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52294987
82Cocaine addiction_Homo sapiens_hsa050300.51914794
83Dorso-ventral axis formation_Homo sapiens_hsa043200.51381033
84Tight junction_Homo sapiens_hsa045300.50401922
85MAPK signaling pathway_Homo sapiens_hsa040100.50345411
86Protein export_Homo sapiens_hsa030600.50284625
87Retinol metabolism_Homo sapiens_hsa008300.50238832
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.49792465
89Thyroid cancer_Homo sapiens_hsa052160.48750772
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48481924
91Glutamatergic synapse_Homo sapiens_hsa047240.48478541
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48452398
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47806412
94Basal cell carcinoma_Homo sapiens_hsa052170.45643262
95Glutathione metabolism_Homo sapiens_hsa004800.45397704
96Steroid biosynthesis_Homo sapiens_hsa001000.44929760
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44903591
98Galactose metabolism_Homo sapiens_hsa000520.43859405
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.43573518
100ErbB signaling pathway_Homo sapiens_hsa040120.42216743
101Small cell lung cancer_Homo sapiens_hsa052220.42187615
102Hepatitis C_Homo sapiens_hsa051600.41479504
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41047385
104MicroRNAs in cancer_Homo sapiens_hsa052060.40557207
105Shigellosis_Homo sapiens_hsa051310.40328438
106Colorectal cancer_Homo sapiens_hsa052100.39979012
107Rap1 signaling pathway_Homo sapiens_hsa040150.39765099
108Dopaminergic synapse_Homo sapiens_hsa047280.39025049
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.38953853
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38515309
111Parkinsons disease_Homo sapiens_hsa050120.38318505
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38187469
113Chronic myeloid leukemia_Homo sapiens_hsa052200.37772500
114Measles_Homo sapiens_hsa051620.37761894
115Notch signaling pathway_Homo sapiens_hsa043300.37671720
116Folate biosynthesis_Homo sapiens_hsa007900.37453723
117Hepatitis B_Homo sapiens_hsa051610.37347818
118Bile secretion_Homo sapiens_hsa049760.37136729
119Choline metabolism in cancer_Homo sapiens_hsa052310.36501957
120GnRH signaling pathway_Homo sapiens_hsa049120.35106705
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34261191
122Apoptosis_Homo sapiens_hsa042100.34057697
123Bladder cancer_Homo sapiens_hsa052190.32470735
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31896886
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31860991
126Vibrio cholerae infection_Homo sapiens_hsa051100.31146992
127Vitamin B6 metabolism_Homo sapiens_hsa007500.31093650
128Insulin secretion_Homo sapiens_hsa049110.31029679
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30946161
130HIF-1 signaling pathway_Homo sapiens_hsa040660.29951368
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29922072
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29395770
133Acute myeloid leukemia_Homo sapiens_hsa052210.29377985
134Pyruvate metabolism_Homo sapiens_hsa006200.28721376
135Ras signaling pathway_Homo sapiens_hsa040140.28249621
136Dilated cardiomyopathy_Homo sapiens_hsa054140.27736857
137mTOR signaling pathway_Homo sapiens_hsa041500.27629440
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25656557
139Hedgehog signaling pathway_Homo sapiens_hsa043400.25330910
140Gastric acid secretion_Homo sapiens_hsa049710.23679602
141Ovarian steroidogenesis_Homo sapiens_hsa049130.23384577
142Phototransduction_Homo sapiens_hsa047440.22906019
143Hippo signaling pathway_Homo sapiens_hsa043900.22279057
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21110963
145Pathways in cancer_Homo sapiens_hsa052000.20014459
146B cell receptor signaling pathway_Homo sapiens_hsa046620.19463354
147Influenza A_Homo sapiens_hsa051640.17166841
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16651579
149Metabolic pathways_Homo sapiens_hsa011000.15956091
150Non-small cell lung cancer_Homo sapiens_hsa052230.14606916
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12306805
152Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.11123508
153Wnt signaling pathway_Homo sapiens_hsa043100.10767762
154Renin-angiotensin system_Homo sapiens_hsa046140.10552135
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10534063
156Pancreatic cancer_Homo sapiens_hsa052120.09516755
157Glucagon signaling pathway_Homo sapiens_hsa049220.09507179
1582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.08350682
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08157588
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.07666933
161Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.07043580
162TGF-beta signaling pathway_Homo sapiens_hsa043500.06369545

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