ENO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.35277486
2IMP biosynthetic process (GO:0006188)5.37543200
3nucleobase biosynthetic process (GO:0046112)4.86011149
4folic acid-containing compound biosynthetic process (GO:0009396)4.72920218
5DNA strand elongation involved in DNA replication (GO:0006271)4.69012055
6protein localization to kinetochore (GO:0034501)4.67303263
7DNA replication initiation (GO:0006270)4.58301467
8peptidyl-arginine omega-N-methylation (GO:0035247)4.57924453
9IMP metabolic process (GO:0046040)4.48577805
10DNA strand elongation (GO:0022616)4.42043426
11formation of translation preinitiation complex (GO:0001731)4.41678754
12establishment of integrated proviral latency (GO:0075713)4.38783130
13mitotic nuclear envelope disassembly (GO:0007077)4.32762333
14nuclear pore organization (GO:0006999)4.14781651
15histone arginine methylation (GO:0034969)4.13869718
16purine nucleobase biosynthetic process (GO:0009113)4.12368954
17L-serine metabolic process (GO:0006563)4.03062841
18membrane disassembly (GO:0030397)4.01425300
19nuclear envelope disassembly (GO:0051081)4.01425300
20regulation of translational termination (GO:0006449)3.96425890
21* glycolytic process (GO:0006096)3.94009378
22regulation of translational fidelity (GO:0006450)3.91298613
23telomere maintenance via semi-conservative replication (GO:0032201)3.89368020
24mitotic sister chromatid segregation (GO:0000070)3.88604795
25DNA replication-dependent nucleosome organization (GO:0034723)3.85765883
26DNA replication-dependent nucleosome assembly (GO:0006335)3.85765883
27peptidyl-arginine N-methylation (GO:0035246)3.85763132
28peptidyl-arginine methylation (GO:0018216)3.85763132
29heterochromatin organization (GO:0070828)3.82604832
30mitotic metaphase plate congression (GO:0007080)3.81464280
31nuclear pore complex assembly (GO:0051292)3.73886113
32pre-miRNA processing (GO:0031054)3.73821868
33COPI coating of Golgi vesicle (GO:0048205)3.70627529
34Golgi transport vesicle coating (GO:0048200)3.70627529
35DNA duplex unwinding (GO:0032508)3.69352194
36DNA geometric change (GO:0032392)3.66559285
37regulation of posttranscriptional gene silencing (GO:0060147)3.64400473
38regulation of gene silencing by miRNA (GO:0060964)3.64400473
39regulation of gene silencing by RNA (GO:0060966)3.64400473
40protein localization to chromosome, centromeric region (GO:0071459)3.63790457
41pentose-phosphate shunt (GO:0006098)3.55183917
42sister chromatid segregation (GO:0000819)3.53864306
43regulation of protein heterodimerization activity (GO:0043497)3.53659692
44ribosome assembly (GO:0042255)3.48741270
45protein maturation by protein folding (GO:0022417)3.48365768
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.46718622
47DNA replication checkpoint (GO:0000076)3.41969630
48ribosome biogenesis (GO:0042254)3.41891206
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.41403384
50telomere maintenance via recombination (GO:0000722)3.39347802
51spliceosomal snRNP assembly (GO:0000387)3.38322774
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36563537
53negative regulation of ligase activity (GO:0051352)3.36563537
54double-strand break repair via nonhomologous end joining (GO:0006303)3.32289932
55non-recombinational repair (GO:0000726)3.32289932
56postreplication repair (GO:0006301)3.31954367
57proline biosynthetic process (GO:0006561)3.30682355
58establishment of viral latency (GO:0019043)3.29695286
59mitotic recombination (GO:0006312)3.28507283
60tRNA aminoacylation for protein translation (GO:0006418)3.27813798
61maturation of SSU-rRNA (GO:0030490)3.27535251
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.20096125
63metaphase plate congression (GO:0051310)3.19991864
64amino acid activation (GO:0043038)3.19197697
65tRNA aminoacylation (GO:0043039)3.19197697
66telomere maintenance via telomere lengthening (GO:0010833)3.19056622
67establishment of chromosome localization (GO:0051303)3.18157642
68protein complex localization (GO:0031503)3.17282573
69proteasome assembly (GO:0043248)3.15519400
70DNA ligation (GO:0006266)3.14892128
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12548223
72mitotic chromosome condensation (GO:0007076)3.11710790
73NADPH regeneration (GO:0006740)3.08769177
74regulation of spindle organization (GO:0090224)3.08005909
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06221121
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.06221121
77CENP-A containing nucleosome assembly (GO:0034080)3.05210661
78negative regulation of RNA splicing (GO:0033119)3.04450278
79paraxial mesoderm development (GO:0048339)3.03453523
80mRNA splicing, via spliceosome (GO:0000398)3.01020636
81RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.01020636
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00909199
83chromatin remodeling at centromere (GO:0031055)3.00590279
84ribosomal small subunit assembly (GO:0000028)2.99683850
85RNA splicing, via transesterification reactions (GO:0000375)2.99232757
86nuclear envelope organization (GO:0006998)2.98253968
87viral mRNA export from host cell nucleus (GO:0046784)2.97656577
88DNA topological change (GO:0006265)2.97441914
89nucleobase-containing small molecule interconversion (GO:0015949)2.97419305
90spindle checkpoint (GO:0031577)2.96768559
91regulation of translational elongation (GO:0006448)2.95788002
92nodal signaling pathway (GO:0038092)2.95389817
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95382020
94ribonucleoprotein complex biogenesis (GO:0022613)2.95109028
95base-excision repair (GO:0006284)2.94780768
96regulation of chromosome segregation (GO:0051983)2.93652691
97histone H2A acetylation (GO:0043968)2.90328657
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89628633
99regulation of centrosome cycle (GO:0046605)2.88228363
100glucose 6-phosphate metabolic process (GO:0051156)2.88076682
101cellular protein complex localization (GO:0034629)2.87646234
102mitotic spindle checkpoint (GO:0071174)2.86952996
103cullin deneddylation (GO:0010388)2.85101997
104negative regulation of histone methylation (GO:0031061)2.84555739
105regulation of mitotic spindle organization (GO:0060236)2.84348195
106regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.84266455
107negative regulation of mRNA processing (GO:0050686)2.84256821
108serine family amino acid biosynthetic process (GO:0009070)2.83624752
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83553317
110cell cycle G1/S phase transition (GO:0044843)2.83135095
111G1/S transition of mitotic cell cycle (GO:0000082)2.83135095
112regulation of ubiquitin-protein transferase activity (GO:0051438)2.83009904
113regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81850783
114transcription-coupled nucleotide-excision repair (GO:0006283)2.80151943
115chaperone-mediated protein complex assembly (GO:0051131)2.79607662
116chromosome segregation (GO:0007059)2.79537244
117translesion synthesis (GO:0019985)2.78808771
118chromosome condensation (GO:0030261)2.78491808
119spliceosomal complex assembly (GO:0000245)2.77683323
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77389429
121signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77104105
122signal transduction involved in DNA damage checkpoint (GO:0072422)2.77104105
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76504989
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76504989
125DNA conformation change (GO:0071103)2.76408119
126de novo protein folding (GO:0006458)2.76259502
127pore complex assembly (GO:0046931)2.75171831
128positive regulation of chromosome segregation (GO:0051984)2.74624491
129regulation of histone H3-K9 methylation (GO:0051570)2.73760851
130translational initiation (GO:0006413)2.72783251
131negative regulation of chromosome segregation (GO:0051985)2.71797308
132translational elongation (GO:0006414)2.70640974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.99293101
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.43503177
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.37432874
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.19105727
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50402571
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.25882572
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87360925
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85422181
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77025530
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.76683304
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63182902
12XRN2_22483619_ChIP-Seq_HELA_Human2.60945074
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53820735
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.49862970
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44711259
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.41428261
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33749274
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33636020
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28381835
20* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.14164017
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.13840072
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13399898
23MYC_22102868_ChIP-Seq_BL_Human2.12146594
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06509092
25AR_21909140_ChIP-Seq_LNCAP_Human2.01221685
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98935772
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93977008
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.93175835
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93078999
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.86120042
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81392430
32* TTF2_22483619_ChIP-Seq_HELA_Human1.80818746
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79057196
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78463179
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78381065
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77258991
37* GABP_19822575_ChIP-Seq_HepG2_Human1.70198798
38* DCP1A_22483619_ChIP-Seq_HELA_Human1.68354101
39FOXP3_21729870_ChIP-Seq_TREG_Human1.67832728
40CIITA_25753668_ChIP-Seq_RAJI_Human1.67154984
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67062245
42VDR_23849224_ChIP-Seq_CD4+_Human1.65408387
43ZNF263_19887448_ChIP-Seq_K562_Human1.63190988
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63156121
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57201669
46* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54195217
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53999944
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49288592
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48689116
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47694848
51* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47297332
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.40584808
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39066521
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38314814
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38026174
56* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37075281
57KDM5A_27292631_Chip-Seq_BREAST_Human1.37074248
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35969361
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35341539
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31779748
61ELK1_19687146_ChIP-ChIP_HELA_Human1.27330268
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27277309
63* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27247452
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26230122
65* VDR_21846776_ChIP-Seq_THP-1_Human1.24049242
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22418897
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21997215
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21429749
69TFEB_21752829_ChIP-Seq_HELA_Human1.20100710
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19360402
71* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18748340
72* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17000111
73* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15142782
74CLOCK_20551151_ChIP-Seq_293T_Human1.14470779
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11571231
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11018191
77* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10931144
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10308505
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10167427
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09465023
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08499950
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07982193
83* SOX17_20123909_ChIP-Seq_XEN_Mouse1.07948005
84* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05764420
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04958844
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04748880
87* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04237650
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02703712
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02008425
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.01728353
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00677062
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00549274
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00066957
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99069718
95* NANOG_21062744_ChIP-ChIP_HESCs_Human0.98613905
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96646027
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95919092
98* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95421126
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94927001
100* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93760572
101MYC_18940864_ChIP-ChIP_HL60_Human0.90339821
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89538668
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88705777
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88092722
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87321811
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86605911
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86586089
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85964376
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85957480
110* CHD1_26751641_Chip-Seq_LNCaP_Human0.84835639
111* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84586290
112* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84585771
113* TP63_19390658_ChIP-ChIP_HaCaT_Human0.84301853
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81781311
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81608708
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80969346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.12523934
2MP0003111_abnormal_nucleus_morphology4.06771480
3MP0003693_abnormal_embryo_hatching4.01012760
4MP0004957_abnormal_blastocyst_morpholog3.98104960
5MP0003123_paternal_imprinting3.89116677
6MP0003077_abnormal_cell_cycle3.66129826
7MP0010030_abnormal_orbit_morphology3.17691522
8MP0002877_abnormal_melanocyte_morpholog2.87243076
9MP0010352_gastrointestinal_tract_polyps2.77641112
10MP0008007_abnormal_cellular_replicative2.76217300
11* MP0001730_embryonic_growth_arrest2.63040503
12MP0008932_abnormal_embryonic_tissue2.58713159
13MP0008057_abnormal_DNA_replication2.51223339
14MP0010307_abnormal_tumor_latency2.44069990
15MP0003121_genomic_imprinting2.42683484
16MP0000350_abnormal_cell_proliferation2.36831652
17MP0008058_abnormal_DNA_repair2.34947004
18MP0009697_abnormal_copulation2.25223441
19MP0002653_abnormal_ependyma_morphology2.20718692
20MP0004233_abnormal_muscle_weight2.20369368
21MP0008877_abnormal_DNA_methylation2.13135258
22MP0005257_abnormal_intraocular_pressure2.01991249
23MP0005076_abnormal_cell_differentiation1.95884768
24* MP0001697_abnormal_embryo_size1.91646283
25MP0004272_abnormal_basement_membrane1.89638863
26MP0005380_embryogenesis_phenotype1.87356551
27MP0001672_abnormal_embryogenesis/_devel1.87356551
28MP0003705_abnormal_hypodermis_morpholog1.85750203
29MP0004133_heterotaxia1.76736807
30MP0003984_embryonic_growth_retardation1.75232365
31MP0002085_abnormal_embryonic_tissue1.75076213
32* MP0002080_prenatal_lethality1.74467006
33MP0003890_abnormal_embryonic-extraembry1.74338070
34MP0002084_abnormal_developmental_patter1.71777855
35MP0002088_abnormal_embryonic_growth/wei1.70534669
36MP0003122_maternal_imprinting1.69973031
37MP0004197_abnormal_fetal_growth/weight/1.69029284
38MP0009053_abnormal_anal_canal1.65598751
39MP0000537_abnormal_urethra_morphology1.64866272
40MP0003718_maternal_effect1.52730893
41MP0002086_abnormal_extraembryonic_tissu1.42722342
42MP0010234_abnormal_vibrissa_follicle1.39171811
43MP0003566_abnormal_cell_adhesion1.37998539
44MP0003119_abnormal_digestive_system1.35214835
45MP0002089_abnormal_postnatal_growth/wei1.35140334
46MP0000313_abnormal_cell_death1.28301814
47MP0001661_extended_life_span1.27864068
48MP0001293_anophthalmia1.27678938
49MP0006035_abnormal_mitochondrial_morpho1.23033713
50MP0008260_abnormal_autophagy1.20772001
51MP0005023_abnormal_wound_healing1.20142367
52MP0002160_abnormal_reproductive_system1.16643377
53MP0004808_abnormal_hematopoietic_stem1.13731541
54MP0003011_delayed_dark_adaptation1.12671258
55MP0003941_abnormal_skin_development1.11966855
56MP0000358_abnormal_cell_content/1.11929083
57MP0002938_white_spotting1.10954670
58MP0002019_abnormal_tumor_incidence1.09036352
59MP0005253_abnormal_eye_physiology1.08814971
60MP0003806_abnormal_nucleotide_metabolis1.08610415
61MP0009672_abnormal_birth_weight1.08483008
62MP0002396_abnormal_hematopoietic_system1.08123039
63MP0000858_altered_metastatic_potential1.07736361
64MP0005501_abnormal_skin_physiology1.06817088
65MP0003186_abnormal_redox_activity1.04993235
66MP0008438_abnormal_cutaneous_collagen1.03168116
67MP0003567_abnormal_fetal_cardiomyocyte1.01334822
68MP0001346_abnormal_lacrimal_gland1.01332299
69MP0005551_abnormal_eye_electrophysiolog1.01291135
70MP0006072_abnormal_retinal_apoptosis1.00935212
71MP0003385_abnormal_body_wall1.00317230
72MP0009333_abnormal_splenocyte_physiolog0.99061003
73MP0001915_intracranial_hemorrhage0.98603125
74MP0005384_cellular_phenotype0.97889102
75MP0002111_abnormal_tail_morphology0.97804637
76MP0000490_abnormal_crypts_of0.97781539
77MP0002092_abnormal_eye_morphology0.97646867
78MP0003942_abnormal_urinary_system0.96791151
79MP0001849_ear_inflammation0.93340404
80MP0003786_premature_aging0.92545468
81MP0000372_irregular_coat_pigmentation0.92196129
82MP0003315_abnormal_perineum_morphology0.91420878
83MP0005451_abnormal_body_composition0.89866865
84MP0008770_decreased_survivor_rate0.88290221
85MP0000762_abnormal_tongue_morphology0.88136997
86MP0000703_abnormal_thymus_morphology0.85380633
87MP0000428_abnormal_craniofacial_morphol0.84609186
88MP0000534_abnormal_ureter_morphology0.84560062
89MP0002060_abnormal_skin_morphology0.84267814
90MP0004084_abnormal_cardiac_muscle0.84194912
91MP0000579_abnormal_nail_morphology0.84048940
92MP0005621_abnormal_cell_physiology0.82900933
93MP0003283_abnormal_digestive_organ0.82826529
94MP0005197_abnormal_uvea_morphology0.82485025
95MP0000678_abnormal_parathyroid_gland0.81477141
96MP0002282_abnormal_trachea_morphology0.81163846
97MP0003861_abnormal_nervous_system0.80204900
98MP0003115_abnormal_respiratory_system0.80046239
99MP0005391_vision/eye_phenotype0.79348024
100MP0001529_abnormal_vocalization0.78205668
101MP0000750_abnormal_muscle_regeneration0.74115454
102MP0001727_abnormal_embryo_implantation0.73491515
103MP0001881_abnormal_mammary_gland0.73269834
104MP0002722_abnormal_immune_system0.71980788
105MP0002751_abnormal_autonomic_nervous0.71567184
106MP0002233_abnormal_nose_morphology0.71410831
107MP0003950_abnormal_plasma_membrane0.70971623
108MP0002210_abnormal_sex_determination0.70865355
109MP0001286_abnormal_eye_development0.70458328
110MP0005623_abnormal_meninges_morphology0.69625234
111MP0002697_abnormal_eye_size0.69146746
112MP0003172_abnormal_lysosome_physiology0.68710118
113MP0008789_abnormal_olfactory_epithelium0.68302095
114MP0000647_abnormal_sebaceous_gland0.68019326
115MP0006292_abnormal_olfactory_placode0.67479900
116MP0006036_abnormal_mitochondrial_physio0.66731810
117MP0001299_abnormal_eye_distance/0.66107536
118MP0003943_abnormal_hepatobiliary_system0.65348927
119MP0003221_abnormal_cardiomyocyte_apopto0.65205047
120MP0000627_abnormal_mammary_gland0.63972079
121MP0003755_abnormal_palate_morphology0.63661399
122MP0004858_abnormal_nervous_system0.63341136
123MP0000371_diluted_coat_color0.63217491
124MP0005171_absent_coat_pigmentation0.62995263
125MP0005394_taste/olfaction_phenotype0.62567067
126MP0005499_abnormal_olfactory_system0.62567067
127MP0002925_abnormal_cardiovascular_devel0.61763356
128MP0001324_abnormal_eye_pigmentation0.61065775
129MP0005248_abnormal_Harderian_gland0.60912661
130MP0009703_decreased_birth_body0.60457164
131MP0005330_cardiomyopathy0.60149553
132MP0005193_abnormal_anterior_eye0.59552874
133MP0001145_abnormal_male_reproductive0.59402805
134MP0005266_abnormal_metabolism0.58954289
135MP0000733_abnormal_muscle_development0.58096429
136MP0000049_abnormal_middle_ear0.58040286
137MP0002269_muscular_atrophy0.55980423
138MP0002127_abnormal_cardiovascular_syste0.54735313
139MP0003937_abnormal_limbs/digits/tail_de0.53909213

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.28316158
2Increased serum pyruvate (HP:0003542)4.28316158
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.09899689
4Ependymoma (HP:0002888)4.08750983
5Selective tooth agenesis (HP:0001592)3.91411102
6Chromsome breakage (HP:0040012)3.72641201
7Cholecystitis (HP:0001082)3.45889179
8Abnormal gallbladder physiology (HP:0012438)3.45889179
9Congenital stationary night blindness (HP:0007642)3.45091977
10Abnormal number of incisors (HP:0011064)3.38768756
11Agnosia (HP:0010524)3.37841999
12Birth length less than 3rd percentile (HP:0003561)3.35881319
13Microvesicular hepatic steatosis (HP:0001414)3.24061000
14Colon cancer (HP:0003003)3.22357181
15Medulloblastoma (HP:0002885)3.12707997
16Degeneration of anterior horn cells (HP:0002398)2.96766622
17Abnormality of the anterior horn cell (HP:0006802)2.96766622
18Abnormality of the labia minora (HP:0012880)2.90378398
19Abnormality of the astrocytes (HP:0100707)2.85280414
20Astrocytoma (HP:0009592)2.85280414
21Abnormality of abdominal situs (HP:0011620)2.83504718
22Abdominal situs inversus (HP:0003363)2.83504718
23Cortical dysplasia (HP:0002539)2.80817155
24Adenoma sebaceum (HP:0009720)2.73116302
25Angiofibromas (HP:0010615)2.73116302
26Premature rupture of membranes (HP:0001788)2.63173882
27Abnormality of the preputium (HP:0100587)2.63150949
28Abnormality of the ileum (HP:0001549)2.59953636
29Renal duplication (HP:0000075)2.57810837
30Deviation of the thumb (HP:0009603)2.56622644
31Multiple enchondromatosis (HP:0005701)2.52044776
32Cholelithiasis (HP:0001081)2.49089859
33Reticulocytopenia (HP:0001896)2.48723499
34Increased nuchal translucency (HP:0010880)2.46862925
35Oral leukoplakia (HP:0002745)2.45627604
36Exercise-induced muscle cramps (HP:0003710)2.45183656
37Proximal placement of thumb (HP:0009623)2.43725226
38Cerebral hypomyelination (HP:0006808)2.43106178
39Patellar aplasia (HP:0006443)2.40836827
40Pendular nystagmus (HP:0012043)2.40286733
41Spastic diplegia (HP:0001264)2.37815591
42Rhabdomyolysis (HP:0003201)2.37639926
43Cutaneous melanoma (HP:0012056)2.36319331
44Carpal bone hypoplasia (HP:0001498)2.35858478
45Trismus (HP:0000211)2.33171123
46Insomnia (HP:0100785)2.31222040
47Postnatal microcephaly (HP:0005484)2.29773714
48Severe visual impairment (HP:0001141)2.29259272
49Breast hypoplasia (HP:0003187)2.26929512
50Absent epiphyses (HP:0010577)2.26182069
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.26182069
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.25686441
53Supernumerary spleens (HP:0009799)2.25167979
54Aplasia/Hypoplasia of the patella (HP:0006498)2.24136280
55Abnormality of the umbilical cord (HP:0010881)2.23629898
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21613875
57Short 4th metacarpal (HP:0010044)2.21613875
58Abnormal gallbladder morphology (HP:0012437)2.20995363
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.19101902
60Abnormality of chromosome stability (HP:0003220)2.16584243
61Glioma (HP:0009733)2.16421059
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16252562
63Preauricular skin tag (HP:0000384)2.16235342
64Basal cell carcinoma (HP:0002671)2.15317782
65High anterior hairline (HP:0009890)2.14667404
66Type I transferrin isoform profile (HP:0003642)2.14079063
67Progressive muscle weakness (HP:0003323)2.12852310
68Entropion (HP:0000621)2.12674781
69Rhabdomyosarcoma (HP:0002859)2.12499221
70Microglossia (HP:0000171)2.12247858
71Abnormal lung lobation (HP:0002101)2.10465627
72Cellular immunodeficiency (HP:0005374)2.10374139
73Freckling (HP:0001480)2.10054207
74Upper limb muscle weakness (HP:0003484)2.10005594
75Tracheoesophageal fistula (HP:0002575)2.08686500
76Premature graying of hair (HP:0002216)2.08591933
77Skin tags (HP:0010609)2.08300831
78Secondary amenorrhea (HP:0000869)2.07149144
79Missing ribs (HP:0000921)2.06502441
80Aplasia/hypoplasia of the humerus (HP:0006507)2.06388134
81Hyperacusis (HP:0010780)2.06157720
82Hypoplastic pelvis (HP:0008839)2.04922161
83Increased density of long bones (HP:0006392)2.03445967
84Progressive external ophthalmoplegia (HP:0000590)2.02154071
85Absent radius (HP:0003974)2.01500986
86Squamous cell carcinoma (HP:0002860)2.00748798
87Pointed chin (HP:0000307)1.99633479
88Long palpebral fissure (HP:0000637)1.99628681
89Neoplasm of the pancreas (HP:0002894)1.99060722
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98849649
91Neuroblastic tumors (HP:0004376)1.98509263
92Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.98509263
93Neuroblastoma (HP:0003006)1.98509263
94Primitive neuroectodermal tumor (HP:0030065)1.98509263
95Short nail (HP:0001799)1.97665304
96Abnormality of the carotid arteries (HP:0005344)1.96037168
97Rough bone trabeculation (HP:0100670)1.94976410
98Aplasia involving forearm bones (HP:0009822)1.93376188
99Absent forearm bone (HP:0003953)1.93376188
100Abnormality of methionine metabolism (HP:0010901)1.91736776
101Hand muscle atrophy (HP:0009130)1.90562094
102Abnormality of the gallbladder (HP:0005264)1.90190871
103Bony spicule pigmentary retinopathy (HP:0007737)1.89781653
104Neoplasm of striated muscle (HP:0009728)1.88979644
105Small epiphyses (HP:0010585)1.88942104
106Absent thumb (HP:0009777)1.87369546
107Abnormality of the lower motor neuron (HP:0002366)1.87047421
108Overriding aorta (HP:0002623)1.86796950
109Atresia of the external auditory canal (HP:0000413)1.85946902
110Short humerus (HP:0005792)1.85626664
111Emotional lability (HP:0000712)1.85259266
112Choanal atresia (HP:0000453)1.85216839
113Myoglobinuria (HP:0002913)1.83826188
114Ovarian neoplasm (HP:0100615)1.83647297
115Intestinal polyp (HP:0005266)1.83451148
116High pitched voice (HP:0001620)1.83330022
117Nephroblastoma (Wilms tumor) (HP:0002667)1.82962730
118Unsteady gait (HP:0002317)1.80848655
119Horseshoe kidney (HP:0000085)1.80848001
120Shoulder girdle muscle weakness (HP:0003547)1.80592437
121Ragged-red muscle fibers (HP:0003200)1.80050178
122Myelodysplasia (HP:0002863)1.79401438
123Metaphyseal cupping (HP:0003021)1.77779853
124Duodenal stenosis (HP:0100867)1.77429842
125Small intestinal stenosis (HP:0012848)1.77429842
126Meckel diverticulum (HP:0002245)1.77326612
127Abnormalities of placenta or umbilical cord (HP:0001194)1.77150834
128Overlapping toe (HP:0001845)1.76733322
129Aplastic anemia (HP:0001915)1.75845816
130Intestinal polyposis (HP:0200008)1.75568934
131Abnormality of reticulocytes (HP:0004312)1.75520957
132Glossoptosis (HP:0000162)1.75241132
133Breast aplasia (HP:0100783)1.75225141
13411 pairs of ribs (HP:0000878)1.75007216
135Broad distal phalanx of finger (HP:0009836)1.74378831
136Ulnar bowing (HP:0003031)1.73934477
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.73450287
138Reduced antithrombin III activity (HP:0001976)1.73083006
139Posterior subcapsular cataract (HP:0007787)1.72695465
140Abnormality of the calcaneus (HP:0008364)1.72372878
141Abnormality of the fetal cardiovascular system (HP:0010948)1.71908725
142Abnormal umbilical cord blood vessels (HP:0011403)1.71908725
143Single umbilical artery (HP:0001195)1.71908725
144Trigonocephaly (HP:0000243)1.71792137
145Impaired proprioception (HP:0010831)1.71360212
146Abnormality of the motor neurons (HP:0002450)1.70926923
147Abnormal neuron morphology (HP:0012757)1.70926923
148Facial cleft (HP:0002006)1.70614104
149Slender long bone (HP:0003100)1.70377862
150Embryonal renal neoplasm (HP:0011794)1.67806951
151Reticulocytosis (HP:0001923)1.67407264
152Breech presentation (HP:0001623)1.64610183
153Abnormal protein glycosylation (HP:0012346)1.64238707
154Abnormal glycosylation (HP:0012345)1.64238707
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64238707
156Abnormal protein N-linked glycosylation (HP:0012347)1.64238707
157Prominent metopic ridge (HP:0005487)1.63337621
158Orthostatic hypotension (HP:0001278)1.62293497
159Pterygium (HP:0001059)1.61098361
160Abnormality of the duodenum (HP:0002246)1.59773496
161Generalized hypotonia (HP:0001290)1.59205114
162Exercise intolerance (HP:0003546)1.59137573
163Elfin facies (HP:0004428)1.56685138
164Poikiloderma (HP:0001029)1.56290098
165Abnormality of oral frenula (HP:0000190)1.55337274
166Cafe-au-lait spot (HP:0000957)1.54878981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.35914631
2TSSK64.29708972
3NEK13.89060221
4CDC73.64066888
5PKN23.53150532
6TESK23.04393706
7WEE13.03995822
8VRK22.97796137
9TESK12.44094502
10EIF2AK12.43481093
11EEF2K2.35002292
12SMG12.19634333
13PASK2.13799802
14PAK42.11648053
15TRIM281.97212298
16NEK21.93792513
17PLK31.72463446
18TTK1.69237056
19TRIB31.65124278
20RPS6KB21.62434694
21SCYL21.61364470
22MST1R1.61029277
23FGFR11.55419357
24MAP3K81.47722952
25PLK11.45607605
26IRAK31.44916053
27ATR1.40892539
28CDK121.40529712
29ERBB41.33050672
30LIMK11.32109301
31CDK71.30224672
32MAP3K101.30114954
33SRPK11.28385331
34ALK1.27110956
35STK101.26889377
36BCKDK1.25104964
37ICK1.20682354
38TGFBR11.18770578
39DAPK11.18546092
40PBK1.12726134
41FLT31.12022362
42KDR1.11624327
43AURKB1.11622659
44MKNK11.11317072
45CDK81.11219506
46GRK61.10807534
47MST41.09573186
48AURKA1.08514969
49CHEK11.06751459
50BRSK11.06118175
51STK161.06097061
52CDK41.05199803
53BCR1.04747618
54LRRK21.04298910
55MAP3K121.01363644
56LATS21.00043800
57EIF2AK20.96576334
58PLK40.95735202
59TAF10.90543236
60BMX0.90364770
61RPS6KA40.90334453
62MOS0.90070871
63PAK10.89826458
64EPHA20.86587950
65PDK20.84602667
66EIF2AK30.83385516
67PLK20.82797549
68CDK180.81745152
69CCNB10.80828027
70CDK150.79271606
71MAP3K110.78769970
72ZAK0.76469769
73CDK140.75642936
74CDK20.74932923
75MKNK20.73724165
76CHEK20.73663397
77CDK11A0.72575365
78MINK10.69990575
79LMTK20.69417764
80BRSK20.69058165
81KSR10.67373691
82AKT20.67273104
83ILK0.66235157
84NTRK10.66164400
85TAOK20.63524329
86TTN0.61114634
87ATM0.60844101
88BRD40.60612589
89NME10.59289682
90CDK10.57477419
91PNCK0.56909575
92PTK20.56135878
93CSNK2A20.54770630
94VRK10.53729248
95BRAF0.52566121
96KSR20.50917352
97MAP4K10.50656291
98CDK90.48925692
99DAPK30.47261507
100PDK30.46819004
101PDK40.46819004
102CSNK2A10.46785956
103STK38L0.46067492
104CSNK1G30.45363824
105STK40.44026369
106MTOR0.43872626
107PAK20.43460750
108CDK60.43047380
109RAF10.42548588
110CSNK1E0.41321046
111MAP3K90.39958841
112NME20.39213854
113TLK10.39008838
114CSNK1A1L0.36815218
115SIK30.35318910
116PIM20.35132496
117CLK10.33927239
118PRKDC0.33150099
119PTK60.33081061
120ACVR1B0.32871444
121PRKCI0.27803613
122MET0.26221438
123ARAF0.26205862
124MAP2K30.25544746
125ROCK20.23489976

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44310746
2Mismatch repair_Homo sapiens_hsa034303.81360662
3Spliceosome_Homo sapiens_hsa030403.17784797
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.11311899
5Proteasome_Homo sapiens_hsa030503.09725167
6One carbon pool by folate_Homo sapiens_hsa006702.99643613
7RNA transport_Homo sapiens_hsa030132.94197018
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93134260
9Base excision repair_Homo sapiens_hsa034102.63869688
10* Biosynthesis of amino acids_Homo sapiens_hsa012302.55570182
11Nucleotide excision repair_Homo sapiens_hsa034202.39923834
12* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.38794443
13Cell cycle_Homo sapiens_hsa041102.37678932
14RNA polymerase_Homo sapiens_hsa030202.16216963
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15230323
16Ribosome_Homo sapiens_hsa030102.09349645
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07818770
18Homologous recombination_Homo sapiens_hsa034401.95572078
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.87402358
20Pyrimidine metabolism_Homo sapiens_hsa002401.71835136
21* Carbon metabolism_Homo sapiens_hsa012001.71782444
22Fructose and mannose metabolism_Homo sapiens_hsa000511.69393164
23Pentose phosphate pathway_Homo sapiens_hsa000301.63464217
24Vitamin B6 metabolism_Homo sapiens_hsa007501.63191079
25mRNA surveillance pathway_Homo sapiens_hsa030151.56579007
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.55981184
27Steroid biosynthesis_Homo sapiens_hsa001001.50356747
28Phototransduction_Homo sapiens_hsa047441.38493306
29* RNA degradation_Homo sapiens_hsa030181.36612121
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34842047
31Fatty acid elongation_Homo sapiens_hsa000621.34616047
32* HIF-1 signaling pathway_Homo sapiens_hsa040661.22811762
33Non-homologous end-joining_Homo sapiens_hsa034501.22365667
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.21334176
35Pyruvate metabolism_Homo sapiens_hsa006201.21168825
36Galactose metabolism_Homo sapiens_hsa000521.20244382
37Fanconi anemia pathway_Homo sapiens_hsa034601.19425073
38Oocyte meiosis_Homo sapiens_hsa041141.13931808
39p53 signaling pathway_Homo sapiens_hsa041151.10339236
40Epstein-Barr virus infection_Homo sapiens_hsa051691.10164173
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10042232
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08079829
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07683994
44Protein export_Homo sapiens_hsa030601.06021687
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01410475
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00763989
47Purine metabolism_Homo sapiens_hsa002300.98829467
48Folate biosynthesis_Homo sapiens_hsa007900.97860550
49Viral carcinogenesis_Homo sapiens_hsa052030.96821235
50Propanoate metabolism_Homo sapiens_hsa006400.96163420
51Sulfur relay system_Homo sapiens_hsa041220.94065738
52Synaptic vesicle cycle_Homo sapiens_hsa047210.92557875
53Legionellosis_Homo sapiens_hsa051340.86132862
54HTLV-I infection_Homo sapiens_hsa051660.82639744
55Antigen processing and presentation_Homo sapiens_hsa046120.74573419
56Hippo signaling pathway_Homo sapiens_hsa043900.73421354
57Basal cell carcinoma_Homo sapiens_hsa052170.71355286
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70848256
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69041932
60Basal transcription factors_Homo sapiens_hsa030220.68737982
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68013115
62Thyroid cancer_Homo sapiens_hsa052160.66155647
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63149783
64Lysine degradation_Homo sapiens_hsa003100.62597778
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60187027
66Bladder cancer_Homo sapiens_hsa052190.59850418
67MicroRNAs in cancer_Homo sapiens_hsa052060.58969800
68Vibrio cholerae infection_Homo sapiens_hsa051100.58926958
69Colorectal cancer_Homo sapiens_hsa052100.58909723
70Arginine and proline metabolism_Homo sapiens_hsa003300.58546348
71Fatty acid metabolism_Homo sapiens_hsa012120.56531597
72Shigellosis_Homo sapiens_hsa051310.54192405
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54099350
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52106050
75Parkinsons disease_Homo sapiens_hsa050120.49832479
76Glucagon signaling pathway_Homo sapiens_hsa049220.49333009
77mTOR signaling pathway_Homo sapiens_hsa041500.48979527
78Huntingtons disease_Homo sapiens_hsa050160.48078873
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46669882
80* Metabolic pathways_Homo sapiens_hsa011000.45679893
81Collecting duct acid secretion_Homo sapiens_hsa049660.44740337
82Systemic lupus erythematosus_Homo sapiens_hsa053220.41732047
83Hedgehog signaling pathway_Homo sapiens_hsa043400.40998845
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40484009
85Melanoma_Homo sapiens_hsa052180.38866405
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37990253
87Proteoglycans in cancer_Homo sapiens_hsa052050.37697269
88Viral myocarditis_Homo sapiens_hsa054160.35542680
89Alcoholism_Homo sapiens_hsa050340.33158132
90TGF-beta signaling pathway_Homo sapiens_hsa043500.32411707
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32184372
92Apoptosis_Homo sapiens_hsa042100.31876699
93Oxidative phosphorylation_Homo sapiens_hsa001900.31518214
94Phenylalanine metabolism_Homo sapiens_hsa003600.30922257
95Chronic myeloid leukemia_Homo sapiens_hsa052200.30825863
96Herpes simplex infection_Homo sapiens_hsa051680.30246285
97Adherens junction_Homo sapiens_hsa045200.29909648
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28801426
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.27700991
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26211985
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25960727
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25841263
103Small cell lung cancer_Homo sapiens_hsa052220.25772459
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24096509
105Hepatitis B_Homo sapiens_hsa051610.23824697
106Non-small cell lung cancer_Homo sapiens_hsa052230.23445599
107Pathways in cancer_Homo sapiens_hsa052000.23074647
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23016521
109N-Glycan biosynthesis_Homo sapiens_hsa005100.22400884
110Arginine biosynthesis_Homo sapiens_hsa002200.22288028
111Phagosome_Homo sapiens_hsa041450.21376715
112Notch signaling pathway_Homo sapiens_hsa043300.21198836
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20561017
114Tight junction_Homo sapiens_hsa045300.20102136
115Pancreatic cancer_Homo sapiens_hsa052120.19969937
116Glutathione metabolism_Homo sapiens_hsa004800.18132695
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.17492104
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17423740
119Glioma_Homo sapiens_hsa052140.17212754
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14392102
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.14337248
122Wnt signaling pathway_Homo sapiens_hsa043100.13697619
123Type I diabetes mellitus_Homo sapiens_hsa049400.13040719
124Melanogenesis_Homo sapiens_hsa049160.12900357
125Selenocompound metabolism_Homo sapiens_hsa004500.12779013
126Alzheimers disease_Homo sapiens_hsa050100.11445302

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