ENO1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adaptation of signaling pathway (GO:0023058)8.45881317
2tachykinin receptor signaling pathway (GO:0007217)6.55973966
3negative regulation of mast cell activation (GO:0033004)6.42209576
4G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.50789081
5auditory behavior (GO:0031223)5.46097961
6regulation of feeding behavior (GO:0060259)5.25214679
7behavioral response to nicotine (GO:0035095)5.15644580
8presynaptic membrane assembly (GO:0097105)4.82202312
9presynaptic membrane organization (GO:0097090)4.66613565
10positive regulation of synapse assembly (GO:0051965)4.38296519
11pyrimidine nucleobase catabolic process (GO:0006208)4.37813260
12mechanosensory behavior (GO:0007638)4.23213069
13neuronal action potential propagation (GO:0019227)4.21048198
14central nervous system projection neuron axonogenesis (GO:0021952)3.98788638
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.93767105
16response to auditory stimulus (GO:0010996)3.91407945
17postsynaptic membrane organization (GO:0001941)3.89167832
18glutamate receptor signaling pathway (GO:0007215)3.87889479
19axonal fasciculation (GO:0007413)3.78863271
20cerebellar Purkinje cell differentiation (GO:0021702)3.75540954
21gamma-aminobutyric acid transport (GO:0015812)3.74338130
22positive regulation of uterine smooth muscle contraction (GO:0070474)3.71818579
23protein localization to synapse (GO:0035418)3.67172552
24short-term memory (GO:0007614)3.66925604
25synaptic transmission, glutamatergic (GO:0035249)3.66554418
26RNA destabilization (GO:0050779)3.65580785
27nonmotile primary cilium assembly (GO:0035058)3.64986980
28nucleobase catabolic process (GO:0046113)3.64600588
29neurotransmitter-gated ion channel clustering (GO:0072578)3.64533974
30activation of MAPKKK activity (GO:0000185)3.61671851
31establishment of mitochondrion localization (GO:0051654)3.59109261
32positive regulation of dendritic spine morphogenesis (GO:0061003)3.47633519
33neuron recognition (GO:0008038)3.45764801
34protein polyglutamylation (GO:0018095)3.45263230
35righting reflex (GO:0060013)3.44233798
36regulation of synaptic transmission, glutamatergic (GO:0051966)3.42698920
37regulation of memory T cell differentiation (GO:0043380)3.40264779
38positive regulation of dendritic spine development (GO:0060999)3.34602494
39cell migration in hindbrain (GO:0021535)3.33297672
40nerve growth factor signaling pathway (GO:0038180)3.30635858
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.28888453
42regulation of collateral sprouting (GO:0048670)3.28093471
43establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.26802299
44mitochondrion transport along microtubule (GO:0047497)3.26802299
45olfactory bulb development (GO:0021772)3.25302652
46regulation of telomere maintenance (GO:0032204)3.25229132
47long-term memory (GO:0007616)3.22313384
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.19860050
49cerebral cortex radially oriented cell migration (GO:0021799)3.18816674
50regulation of action potential (GO:0098900)3.18322666
51regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.18310776
52positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.18310776
53positive regulation of amino acid transport (GO:0051957)3.17496366
54neuron cell-cell adhesion (GO:0007158)3.15373982
55resolution of meiotic recombination intermediates (GO:0000712)3.12713166
56exploration behavior (GO:0035640)3.11167349
57synaptic transmission, cholinergic (GO:0007271)3.08399554
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05540296
59regulation of cAMP-dependent protein kinase activity (GO:2000479)3.04293101
60regulation of synapse assembly (GO:0051963)3.03491512
61vocalization behavior (GO:0071625)3.01429337
62positive regulation of action potential (GO:0045760)3.01093867
63dendrite morphogenesis (GO:0048813)2.99736031
64prostate gland growth (GO:0060736)2.99337207
65regulation of long-term neuronal synaptic plasticity (GO:0048169)2.98925941
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96199671
67protein K48-linked ubiquitination (GO:0070936)2.95524948
68axon extension (GO:0048675)2.95213785
69positive regulation of gastrulation (GO:2000543)2.95009566
70protein localization to cilium (GO:0061512)2.93164959
71central nervous system neuron axonogenesis (GO:0021955)2.92829385
72glycosphingolipid biosynthetic process (GO:0006688)2.92052905
73dendrite development (GO:0016358)2.92009283
74transmission of nerve impulse (GO:0019226)2.90762316
75negative regulation of axonogenesis (GO:0050771)2.90628993
76establishment of protein localization to Golgi (GO:0072600)2.89562010
77regulation of activation of Janus kinase activity (GO:0010533)2.89560215
78calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.89416148
79neuronal ion channel clustering (GO:0045161)2.89191865
80heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.88670790
81sympathetic nervous system development (GO:0048485)2.88247072
82negative regulation of heart rate (GO:0010459)2.87586962
83retinal ganglion cell axon guidance (GO:0031290)2.86873754
84neuronal action potential (GO:0019228)2.85669105
85neuron-neuron synaptic transmission (GO:0007270)2.83668755
86negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78342503
87positive regulation of cell fate commitment (GO:0010455)2.77052339
88neuromuscular synaptic transmission (GO:0007274)2.75986748
89synapse assembly (GO:0007416)2.75461607
90seminiferous tubule development (GO:0072520)2.75264866
91positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.74697346
92regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.74697346
93primary amino compound metabolic process (GO:1901160)2.73815736
94ADP metabolic process (GO:0046031)2.72489059
95cell differentiation in hindbrain (GO:0021533)2.71618325
96adult walking behavior (GO:0007628)2.70180321
97sex differentiation (GO:0007548)2.69537178
98axonogenesis (GO:0007409)2.67852410
99retina layer formation (GO:0010842)2.67649242
100hindbrain development (GO:0030902)2.66314700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.09328043
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.59418874
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.55811113
4GBX2_23144817_ChIP-Seq_PC3_Human3.51576043
5TAF15_26573619_Chip-Seq_HEK293_Human3.31793768
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.30075009
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.21498708
8IGF1R_20145208_ChIP-Seq_DFB_Human3.09839987
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95537835
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.75961025
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75328974
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.59910734
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44957923
14FUS_26573619_Chip-Seq_HEK293_Human2.44841821
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.35553765
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29660107
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.29117596
18VDR_22108803_ChIP-Seq_LS180_Human2.23516999
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16191241
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15482387
21ZNF274_21170338_ChIP-Seq_K562_Hela2.11226169
22REST_21632747_ChIP-Seq_MESCs_Mouse2.04733368
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.97074165
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96489793
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95159953
26RNF2_27304074_Chip-Seq_NSC_Mouse1.87849108
27EWS_26573619_Chip-Seq_HEK293_Human1.85071809
28P300_19829295_ChIP-Seq_ESCs_Human1.78607818
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.78169147
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77577143
31SMAD4_21799915_ChIP-Seq_A2780_Human1.74262708
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.70287863
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68695359
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68695359
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67191405
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64429259
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64119523
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63597515
39STAT3_23295773_ChIP-Seq_U87_Human1.61701741
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58146854
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57173068
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56633412
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.53188205
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50917865
45CBP_20019798_ChIP-Seq_JUKART_Human1.50917865
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.48144663
47TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.45090280
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44774287
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44540702
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44330104
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.42470887
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.41591640
53AR_25329375_ChIP-Seq_VCAP_Human1.38902310
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.37559978
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.37414243
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.36474784
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33779000
58AR_21572438_ChIP-Seq_LNCaP_Human1.33542327
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.32734781
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.30241448
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.29306504
62TCF4_23295773_ChIP-Seq_U87_Human1.26289779
63RUNX2_22187159_ChIP-Seq_PCA_Human1.24792280
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22623930
65ER_23166858_ChIP-Seq_MCF-7_Human1.21958706
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21733362
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21197106
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20359049
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.19911237
70TP53_22573176_ChIP-Seq_HFKS_Human1.19521284
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18730681
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18730681
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18022713
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17866684
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.17553980
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16636326
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.16340805
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13580771
79SOX9_26525672_Chip-Seq_HEART_Mouse1.11809440
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.11605070
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09204428
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08563844
83DROSHA_22980978_ChIP-Seq_HELA_Human1.07986644
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07902396
85JUN_21703547_ChIP-Seq_K562_Human1.07441067
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06218916
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05550732
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05428474
89KDM2B_26808549_Chip-Seq_REH_Human1.05363751
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05327224
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04051665
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01398792
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00333861
94YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99045434
95SMAD4_21741376_ChIP-Seq_EPCs_Human0.98402381
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.97663021
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96590253
98WDR5_24793694_ChIP-Seq_LNCAP_Human0.95778923
99AR_19668381_ChIP-Seq_PC3_Human0.95700746
100NANOG_19829295_ChIP-Seq_ESCs_Human0.95669753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.64980112
2MP0003787_abnormal_imprinting4.10956190
3MP0004859_abnormal_synaptic_plasticity3.94494313
4MP0005423_abnormal_somatic_nervous3.78149598
5MP0001529_abnormal_vocalization3.58344885
6MP0000569_abnormal_digit_pigmentation3.57398853
7MP0003121_genomic_imprinting3.18518852
8MP0003123_paternal_imprinting3.05487273
9MP0003122_maternal_imprinting2.92846781
10MP0006276_abnormal_autonomic_nervous2.88991461
11MP0001188_hyperpigmentation2.51403639
12MP0002736_abnormal_nociception_after2.49484929
13MP0002735_abnormal_chemical_nociception2.37944165
14MP0002822_catalepsy2.36890067
15MP0001968_abnormal_touch/_nociception2.35086667
16MP0000778_abnormal_nervous_system2.30550204
17MP0003635_abnormal_synaptic_transmissio2.30259992
18MP0004142_abnormal_muscle_tone2.22896407
19MP0009046_muscle_twitch2.17432600
20MP0002063_abnormal_learning/memory/cond2.13661968
21MP0004270_analgesia2.07750033
22MP0002272_abnormal_nervous_system2.07574482
23MP0005386_behavior/neurological_phenoty2.05838853
24MP0004924_abnormal_behavior2.05838853
25MP0009745_abnormal_behavioral_response1.95377398
26MP0002572_abnormal_emotion/affect_behav1.93677729
27MP0008877_abnormal_DNA_methylation1.92208421
28MP0005187_abnormal_penis_morphology1.73644632
29MP0001486_abnormal_startle_reflex1.73046883
30MP0003195_calcinosis1.63448519
31MP0005248_abnormal_Harderian_gland1.58964523
32MP0004885_abnormal_endolymph1.54754055
33MP0004858_abnormal_nervous_system1.52508773
34MP0003890_abnormal_embryonic-extraembry1.51136528
35MP0002067_abnormal_sensory_capabilities1.50369267
36MP0002734_abnormal_mechanical_nocicepti1.49883735
37MP0001970_abnormal_pain_threshold1.46924136
38MP0002184_abnormal_innervation1.44613911
39MP0010386_abnormal_urinary_bladder1.41793321
40MP0006292_abnormal_olfactory_placode1.40253376
41MP0002733_abnormal_thermal_nociception1.36534115
42MP0002638_abnormal_pupillary_reflex1.33467349
43MP0002064_seizures1.33310573
44MP0000955_abnormal_spinal_cord1.33039448
45MP0001440_abnormal_grooming_behavior1.30128139
46MP0003567_abnormal_fetal_cardiomyocyte1.29987137
47MP0002557_abnormal_social/conspecific_i1.29526588
48MP0008569_lethality_at_weaning1.29481581
49MP0004811_abnormal_neuron_physiology1.28886420
50MP0002882_abnormal_neuron_morphology1.27540793
51MP0001905_abnormal_dopamine_level1.26924244
52MP0004133_heterotaxia1.20711810
53MP0006072_abnormal_retinal_apoptosis1.19944787
54MP0002653_abnormal_ependyma_morphology1.13868192
55MP0002751_abnormal_autonomic_nervous1.12554418
56MP0003315_abnormal_perineum_morphology1.10768420
57MP0000647_abnormal_sebaceous_gland1.10318683
58MP0000049_abnormal_middle_ear1.07761997
59MP0001986_abnormal_taste_sensitivity1.02876127
60MP0002066_abnormal_motor_capabilities/c1.00018778
61MP0002102_abnormal_ear_morphology0.99237878
62MP0002152_abnormal_brain_morphology0.97448500
63MP0005551_abnormal_eye_electrophysiolog0.95267521
64MP0003879_abnormal_hair_cell0.91911097
65MP0002752_abnormal_somatic_nervous0.91316367
66MP0002234_abnormal_pharynx_morphology0.89397434
67MP0003861_abnormal_nervous_system0.85467904
68MP0003385_abnormal_body_wall0.84510536
69MP0001501_abnormal_sleep_pattern0.84138252
70MP0002069_abnormal_eating/drinking_beha0.83598337
71MP0003937_abnormal_limbs/digits/tail_de0.82802216
72MP0003942_abnormal_urinary_system0.81530167
73MP0002168_other_aberrant_phenotype0.77353094
74MP0002928_abnormal_bile_duct0.76465610
75MP0004742_abnormal_vestibular_system0.76340844
76MP0003698_abnormal_male_reproductive0.75290064
77MP0009697_abnormal_copulation0.74034136
78MP0000631_abnormal_neuroendocrine_gland0.73440475
79MP0003137_abnormal_impulse_conducting0.71592921
80MP0005645_abnormal_hypothalamus_physiol0.71536664
81MP0004145_abnormal_muscle_electrophysio0.70944083
82MP0001502_abnormal_circadian_rhythm0.70765914
83MP0005171_absent_coat_pigmentation0.70467737
84MP0002177_abnormal_outer_ear0.69567878
85MP0005075_abnormal_melanosome_morpholog0.68047186
86MP0002138_abnormal_hepatobiliary_system0.67713980
87MP0003633_abnormal_nervous_system0.66583238
88MP0003119_abnormal_digestive_system0.65603178
89MP0000026_abnormal_inner_ear0.65492834
90MP0005084_abnormal_gallbladder_morpholo0.65011868
91MP0001943_abnormal_respiration0.64016694
92MP0001485_abnormal_pinna_reflex0.63577564
93MP0001919_abnormal_reproductive_system0.62584295
94MP0005195_abnormal_posterior_eye0.62256574
95MP0005499_abnormal_olfactory_system0.62058885
96MP0005394_taste/olfaction_phenotype0.62058885
97MP0001324_abnormal_eye_pigmentation0.61057976
98MP0002160_abnormal_reproductive_system0.60089444
99MP0005253_abnormal_eye_physiology0.59937435
100MP0005220_abnormal_exocrine_pancreas0.59720075

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.11705843
2Broad-based gait (HP:0002136)4.61184169
3Absent speech (HP:0001344)4.54906026
4Nephronophthisis (HP:0000090)4.23350878
5True hermaphroditism (HP:0010459)4.15000134
6Pancreatic fibrosis (HP:0100732)3.94110133
7Pancreatic cysts (HP:0001737)3.85413405
8Drooling (HP:0002307)3.82773663
9Gait imbalance (HP:0002141)3.82190550
10Tented upper lip vermilion (HP:0010804)3.61218607
11Excessive salivation (HP:0003781)3.56360900
12Congenital primary aphakia (HP:0007707)3.54957056
13Medial flaring of the eyebrow (HP:0010747)3.45230913
14Focal seizures (HP:0007359)3.44527203
15Failure to thrive in infancy (HP:0001531)3.31465580
16Febrile seizures (HP:0002373)3.30348579
17Polyphagia (HP:0002591)3.27190162
18Abnormality of the renal medulla (HP:0100957)3.20419829
19Nephrogenic diabetes insipidus (HP:0009806)3.19531483
20Hyperventilation (HP:0002883)3.16756856
21Degeneration of the lateral corticospinal tracts (HP:0002314)3.12361596
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.12361596
23Atonic seizures (HP:0010819)3.11841119
24Exotropia (HP:0000577)3.11140140
25Abnormality of midbrain morphology (HP:0002418)3.09489339
26Molar tooth sign on MRI (HP:0002419)3.09489339
27Protruding tongue (HP:0010808)3.07684590
28Genetic anticipation (HP:0003743)2.94916530
29Poor coordination (HP:0002370)2.93494217
30Agitation (HP:0000713)2.91699946
31Chronic hepatic failure (HP:0100626)2.89487342
32Genital tract atresia (HP:0001827)2.89119540
33Dialeptic seizures (HP:0011146)2.83537121
34Vaginal atresia (HP:0000148)2.81732538
35Retinal atrophy (HP:0001105)2.80422127
36Abnormality of the corticospinal tract (HP:0002492)2.78070918
37Cystic liver disease (HP:0006706)2.73030769
38Tubulointerstitial nephritis (HP:0001970)2.63658217
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60633203
40Abnormality of alanine metabolism (HP:0010916)2.60633203
41Hyperalaninemia (HP:0003348)2.60633203
42Type II lissencephaly (HP:0007260)2.59791005
43Cerebellar dysplasia (HP:0007033)2.59154031
44Inappropriate behavior (HP:0000719)2.56128050
45Methylmalonic acidemia (HP:0002912)2.54362750
46Status epilepticus (HP:0002133)2.50413968
47Decreased testicular size (HP:0008734)2.48288862
48Fair hair (HP:0002286)2.47120633
49Hypogonadotrophic hypogonadism (HP:0000044)2.44348651
50Volvulus (HP:0002580)2.43029597
51Occipital encephalocele (HP:0002085)2.38536025
52Impaired vibration sensation in the lower limbs (HP:0002166)2.38161716
53Anencephaly (HP:0002323)2.35515264
54Abnormality of the labia minora (HP:0012880)2.35024010
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.34893521
56Abnormality of hair growth rate (HP:0011363)2.32095843
57Slow-growing hair (HP:0002217)2.32095843
58Specific learning disability (HP:0001328)2.31341106
59Hypophosphatemic rickets (HP:0004912)2.31128427
60Shawl scrotum (HP:0000049)2.30435887
61Absence seizures (HP:0002121)2.22566019
62Hyperglycinemia (HP:0002154)2.22432363
63Clumsiness (HP:0002312)2.19607897
64Epileptic encephalopathy (HP:0200134)2.18256442
65Urinary urgency (HP:0000012)2.17822068
66Retinal dysplasia (HP:0007973)2.13106206
67Pachygyria (HP:0001302)2.12354347
68Gastroesophageal reflux (HP:0002020)2.09993352
69Broad foot (HP:0001769)2.09816158
70Poor suck (HP:0002033)2.06016271
71Abnormality of the renal cortex (HP:0011035)2.05846382
72Termporal pattern (HP:0011008)2.05643786
73Insidious onset (HP:0003587)2.05643786
74Narrow forehead (HP:0000341)2.05250790
75Generalized tonic-clonic seizures (HP:0002069)2.05062953
76Sclerocornea (HP:0000647)2.04558904
77Short foot (HP:0001773)2.03382838
78Optic neuritis (HP:0100653)1.96981844
79Retrobulbar optic neuritis (HP:0100654)1.96981844
80Hypothermia (HP:0002045)1.95299637
81Abnormal rod and cone electroretinograms (HP:0008323)1.95224883
82Abnormality of salivation (HP:0100755)1.95052415
83Morphological abnormality of the pyramidal tract (HP:0002062)1.93134792
84Spastic gait (HP:0002064)1.91824472
85Aplasia/Hypoplasia of the lens (HP:0008063)1.90864317
86Progressive cerebellar ataxia (HP:0002073)1.90288426
87Esotropia (HP:0000565)1.90271939
88Postaxial foot polydactyly (HP:0001830)1.88478842
89Lissencephaly (HP:0001339)1.87659627
90Postaxial hand polydactyly (HP:0001162)1.87116673
91Abnormal eating behavior (HP:0100738)1.85921846
92Aplasia/Hypoplasia of the tibia (HP:0005772)1.83579113
93Breast aplasia (HP:0100783)1.82594961
94Generalized hypopigmentation of hair (HP:0011358)1.80131447
95Labial hypoplasia (HP:0000066)1.79950063
96Megalencephaly (HP:0001355)1.78921812
97Myokymia (HP:0002411)1.78880355
98Acute lymphatic leukemia (HP:0006721)1.78048397
99Methylmalonic aciduria (HP:0012120)1.77462070
100Morphological abnormality of the middle ear (HP:0008609)1.77315111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.25078983
2MARK14.87346602
3BRD43.60586319
4WNK33.57719870
5CDK192.94041820
6MAP3K42.80083021
7MKNK22.78163751
8DYRK32.43203299
9MAPK132.28339151
10DYRK22.05151312
11PINK11.97249836
12ERBB31.93563932
13MAP2K71.91156902
14MAP4K21.89557231
15MINK11.81463341
16EPHA31.78330827
17PRKCG1.76166717
18CSNK1G31.74968225
19CSNK1G21.69049238
20FER1.60191965
21MKNK11.60098984
22NTRK21.50606692
23CSNK1A1L1.46223924
24CSNK1G11.34889008
25EPHA41.30038180
26BCR1.27099755
27SRPK11.23075162
28RPS6KA41.19381043
29CAMKK21.18999607
30PRKCQ1.16667960
31MAPK151.16441209
32NTRK31.14398374
33PRKCZ1.13370023
34FRK1.10626082
35TAOK11.09183201
36SIK21.08866749
37PRKCE1.08327022
38TRIM281.03844621
39PNCK1.01277306
40SIK30.97913541
41INSRR0.83661456
42CAMK2A0.82830287
43OXSR10.80305855
44DYRK1A0.79772764
45SGK4940.78454990
46SGK2230.78454990
47CAMK2B0.78042100
48SGK20.77411857
49MAP2K40.76447504
50UHMK10.76447331
51EPHB10.75328802
52ADRBK20.74871921
53BMPR1B0.73631328
54CAMK40.69107367
55PHKG10.68799643
56PHKG20.68799643
57SGK10.67426512
58PAK30.67226316
59PLK40.63704243
60DYRK1B0.60193523
61PLK20.59798990
62ZAK0.58709213
63CDK50.57633361
64CAMK10.56715072
65MAPK100.56203554
66PIM20.54511223
67MAP3K110.54240316
68GRK10.52079450
69IRAK10.49165790
70KSR10.48184303
71RPS6KA50.47649686
72PRKACA0.47611135
73ALK0.46878300
74CSNK1A10.46355707
75RPS6KA20.43491021
76MAPK80.41167947
77LMTK20.38856726
78CHUK0.38694883
79RPS6KA10.37845816
80EPHB20.37628047
81SGK30.37483279
82CSNK1E0.37268265
83CAMKK10.36341569
84CSNK1D0.35537437
85CAMK2D0.35114740
86PBK0.35077254
87STK110.33487048
88PRKCB0.33416328
89CAMK2G0.32222032
90ERBB20.32184104
91PKN10.31213852
92RPS6KA30.30697865
93TLK10.30662574
94AKT30.29646284
95PRKG10.28811399
96PRKCA0.28598560
97PRKCH0.27879881
98GSK3B0.27346526
99EGFR0.27163247
100TNIK0.26344388

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.50753125
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.68822973
3Dorso-ventral axis formation_Homo sapiens_hsa043203.18568891
4Glutamatergic synapse_Homo sapiens_hsa047243.04178222
5GABAergic synapse_Homo sapiens_hsa047272.41863333
6Taste transduction_Homo sapiens_hsa047422.40597200
7Synaptic vesicle cycle_Homo sapiens_hsa047212.33075058
8Amphetamine addiction_Homo sapiens_hsa050312.33061913
9Morphine addiction_Homo sapiens_hsa050322.26021788
10Cocaine addiction_Homo sapiens_hsa050302.19646673
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.09494600
12Protein export_Homo sapiens_hsa030602.01788419
13Circadian entrainment_Homo sapiens_hsa047131.99753614
14Phototransduction_Homo sapiens_hsa047441.97670360
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.96796932
16Dopaminergic synapse_Homo sapiens_hsa047281.89717059
17Long-term potentiation_Homo sapiens_hsa047201.88740563
18Long-term depression_Homo sapiens_hsa047301.83250471
19Axon guidance_Homo sapiens_hsa043601.68780671
20Basal transcription factors_Homo sapiens_hsa030221.60691843
21Serotonergic synapse_Homo sapiens_hsa047261.60544525
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59559725
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58941156
24Fatty acid biosynthesis_Homo sapiens_hsa000611.50419045
25Cholinergic synapse_Homo sapiens_hsa047251.46590635
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38939192
27Gap junction_Homo sapiens_hsa045401.38483171
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28734595
29Olfactory transduction_Homo sapiens_hsa047401.23318814
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22805260
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21075604
32Linoleic acid metabolism_Homo sapiens_hsa005911.16542997
33Steroid biosynthesis_Homo sapiens_hsa001001.16258841
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15950723
35Calcium signaling pathway_Homo sapiens_hsa040201.12946680
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12224610
37RNA polymerase_Homo sapiens_hsa030201.11392215
38Renin secretion_Homo sapiens_hsa049241.05779737
39Fanconi anemia pathway_Homo sapiens_hsa034601.05721516
40Ether lipid metabolism_Homo sapiens_hsa005651.03331316
41Alcoholism_Homo sapiens_hsa050341.02007299
42Butanoate metabolism_Homo sapiens_hsa006500.97417650
43Insulin secretion_Homo sapiens_hsa049110.97238387
44RNA degradation_Homo sapiens_hsa030180.95233137
45Regulation of autophagy_Homo sapiens_hsa041400.94973477
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87520564
47Collecting duct acid secretion_Homo sapiens_hsa049660.86583865
48Salivary secretion_Homo sapiens_hsa049700.85925510
49Oocyte meiosis_Homo sapiens_hsa041140.83589773
50Fat digestion and absorption_Homo sapiens_hsa049750.83229772
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77402875
52cAMP signaling pathway_Homo sapiens_hsa040240.77141073
53Oxytocin signaling pathway_Homo sapiens_hsa049210.74528759
54Parkinsons disease_Homo sapiens_hsa050120.73108265
55Hedgehog signaling pathway_Homo sapiens_hsa043400.72940621
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72204984
57Propanoate metabolism_Homo sapiens_hsa006400.69526831
58Huntingtons disease_Homo sapiens_hsa050160.65845422
59Oxidative phosphorylation_Homo sapiens_hsa001900.61849866
60Ras signaling pathway_Homo sapiens_hsa040140.61183411
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60183201
62Cardiac muscle contraction_Homo sapiens_hsa042600.57036800
63ABC transporters_Homo sapiens_hsa020100.56131847
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54894745
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54345921
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52591464
67Circadian rhythm_Homo sapiens_hsa047100.51862885
68Ovarian steroidogenesis_Homo sapiens_hsa049130.51686510
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45993455
70Purine metabolism_Homo sapiens_hsa002300.45666829
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44839778
72Wnt signaling pathway_Homo sapiens_hsa043100.44818801
73Pyrimidine metabolism_Homo sapiens_hsa002400.43893732
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42928772
75Gastric acid secretion_Homo sapiens_hsa049710.41977497
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41825226
77MAPK signaling pathway_Homo sapiens_hsa040100.40686503
78beta-Alanine metabolism_Homo sapiens_hsa004100.39791718
79Starch and sucrose metabolism_Homo sapiens_hsa005000.38781117
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.38054296
81Hippo signaling pathway_Homo sapiens_hsa043900.37801765
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37558248
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.37214781
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35260834
85Basal cell carcinoma_Homo sapiens_hsa052170.35232300
86Peroxisome_Homo sapiens_hsa041460.33357103
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32710048
88Caffeine metabolism_Homo sapiens_hsa002320.32545357
89Arachidonic acid metabolism_Homo sapiens_hsa005900.32097700
90Fatty acid metabolism_Homo sapiens_hsa012120.30974212
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30193181
92Melanogenesis_Homo sapiens_hsa049160.27238796
93Estrogen signaling pathway_Homo sapiens_hsa049150.27124008
94Selenocompound metabolism_Homo sapiens_hsa004500.26950852
95Glycerolipid metabolism_Homo sapiens_hsa005610.25934217
96Prolactin signaling pathway_Homo sapiens_hsa049170.25906512
97GnRH signaling pathway_Homo sapiens_hsa049120.25496111
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24504125
99Tight junction_Homo sapiens_hsa045300.24409081
100Chemical carcinogenesis_Homo sapiens_hsa052040.23241178

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