ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	phosphate ion transmembrane transport (GO:0035435)	6.10591764
2	phosphate ion transport (GO:0006817)	5.45747927
3	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	5.07842102
4	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.92197223
5	ER overload response (GO:0006983)	4.79970533
6	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	4.76908967
7	urate metabolic process (GO:0046415)	4.70861331
8	nonmotile primary cilium assembly (GO:0035058)	4.63259597
9	adaptation of signaling pathway (GO:0023058)	4.39187858
10	inner ear receptor cell development (GO:0060119)	4.38480289
11	water-soluble vitamin biosynthetic process (GO:0042364)	4.26540836
12	respiratory chain complex IV assembly (GO:0008535)	4.22575328
13	lactate metabolic process (GO:0006089)	3.95838724
14	protein localization to cilium (GO:0061512)	3.91504848
15	signal peptide processing (GO:0006465)	3.79799261
16	replication fork processing (GO:0031297)	3.78417484
17	cytochrome complex assembly (GO:0017004)	3.71657612
18	AMP metabolic process (GO:0046033)	3.61924629
19	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.61483360
20	zinc ion transport (GO:0006829)	3.54130525
21	cellular response to glucose starvation (GO:0042149)	3.44159690
22	transepithelial transport (GO:0070633)	3.43502946
23	regulation of cilium movement (GO:0003352)	3.33712490
24	DNA double-strand break processing (GO:0000729)	3.33066686
25	ADP metabolic process (GO:0046031)	3.31747250
26	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	3.21258533
27	positive regulation of amino acid transport (GO:0051957)	3.19679196
28	negative regulation of execution phase of apoptosis (GO:1900118)	3.17163953
29	ribosome assembly (GO:0042255)	3.10123083
30	dorsal/ventral axis specification (GO:0009950)	3.08962450
31	DNA strand renaturation (GO:0000733)	3.08754643
32	nucleotide transmembrane transport (GO:1901679)	3.03680614
33	synapsis (GO:0007129)	3.03656194
34	regulation of Rac GTPase activity (GO:0032314)	3.01154312
35	striatum development (GO:0021756)	3.00600981
36	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.00131479
37	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.00131479
38	glutathione derivative biosynthetic process (GO:1901687)	2.98456069
39	glutathione derivative metabolic process (GO:1901685)	2.98456069
40	RNA destabilization (GO:0050779)	2.96898848
41	behavioral response to cocaine (GO:0048148)	2.93739774
42	fatty acid elongation (GO:0030497)	2.90808502
43	positive regulation of histone H3-K4 methylation (GO:0051571)	2.89530544
44	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.88942945
45	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.88465953
46	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.87111533
47	iron ion import (GO:0097286)	2.84331655
48	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.83333201
49	anterograde synaptic vesicle transport (GO:0048490)	2.81098152
50	positive regulation of protein autophosphorylation (GO:0031954)	2.80197151
51	negative regulation of response to food (GO:0032096)	2.80145206
52	negative regulation of appetite (GO:0032099)	2.80145206
53	cellular response to gamma radiation (GO:0071480)	2.78900788
54	insulin secretion (GO:0030073)	2.78089678
55	photoreceptor cell maintenance (GO:0045494)	2.77030059
56	protein polyglutamylation (GO:0018095)	2.75563162
57	heparin biosynthetic process (GO:0030210)	2.75492670
58	heparin metabolic process (GO:0030202)	2.75492670
59	response to pheromone (GO:0019236)	2.74901295
60	cellular response to leptin stimulus (GO:0044320)	2.74275367
61	heme transport (GO:0015886)	2.71312366
62	tachykinin receptor signaling pathway (GO:0007217)	2.67045798
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.67025748
64	termination of RNA polymerase III transcription (GO:0006386)	2.67025748
65	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.65293873
66	glutamine metabolic process (GO:0006541)	2.64694606
67	behavioral response to ethanol (GO:0048149)	2.63494584
68	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.62625387
69	auditory receptor cell stereocilium organization (GO:0060088)	2.61662605
70	positive regulation of amine transport (GO:0051954)	2.60276769
71	proteasome assembly (GO:0043248)	2.60177255
72	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.58270313
73	photoreceptor cell differentiation (GO:0046530)	2.58068888
74	eye photoreceptor cell differentiation (GO:0001754)	2.58068888
75	xenobiotic catabolic process (GO:0042178)	2.57509362
76	molting cycle (GO:0042303)	2.55547300
77	hair cycle (GO:0042633)	2.55547300
78	positive regulation of vesicle fusion (GO:0031340)	2.54663968
79	nucleoside diphosphate phosphorylation (GO:0006165)	2.54194793
80	sequestering of metal ion (GO:0051238)	2.53934097
81	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.52737815
82	cellular response to interleukin-6 (GO:0071354)	2.52612490
83	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.51976871
84	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.51549385
85	regulation of protein glycosylation (GO:0060049)	2.50890884
86	lipid particle organization (GO:0034389)	2.50749347
87	regulation of glucokinase activity (GO:0033131)	2.50301823
88	regulation of hexokinase activity (GO:1903299)	2.50301823
89	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.48798126
90	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.48579315
91	meiotic chromosome segregation (GO:0045132)	2.47852747
92	branch elongation of an epithelium (GO:0060602)	2.47479416
93	DNA catabolic process, exonucleolytic (GO:0000738)	2.46516202
94	regulation of integrin-mediated signaling pathway (GO:2001044)	2.45796323
95	cofactor transport (GO:0051181)	2.44287810
96	histone exchange (GO:0043486)	2.43333700
97	pancreas development (GO:0031016)	2.42999721
98	double-strand break repair via homologous recombination (GO:0000724)	2.42512622
99	L-serine metabolic process (GO:0006563)	2.42334367
100	inner mitochondrial membrane organization (GO:0007007)	2.40354872

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.16748894
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.11960486
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.11640879
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.97532044
5	VDR_22108803_ChIP-Seq_LS180_Human	2.92061462
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.85492567
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.76454309
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.56684235
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.55283954
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.41451441
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38572255
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.27008597
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.22759315
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.17581481
15	FUS_26573619_Chip-Seq_HEK293_Human	2.13442452
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.06143073
17	EWS_26573619_Chip-Seq_HEK293_Human	2.02358053
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.01834498
19	P300_19829295_ChIP-Seq_ESCs_Human	1.96830883
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88249978
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86208461
22	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.84410358
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84394773
24	CDX2_22108803_ChIP-Seq_LS180_Human	1.83575939
25	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.83237337
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82934536
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82267334
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.65169204
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64753938
30	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.64290735
31	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.63787075
32	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.57802032
33	TCF4_23295773_ChIP-Seq_U87_Human	1.57378670
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55634054
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.55517874
36	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.52182323
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52178109
38	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49631970
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45558075
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44244169
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43364521
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43364521
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.42909105
44	AR_25329375_ChIP-Seq_VCAP_Human	1.38598971
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37753134
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.37753134
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37172813
48	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36781427
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36080897
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.36079028
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35295157
52	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.33936642
53	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.33633255
54	STAT3_23295773_ChIP-Seq_U87_Human	1.33537879
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31654599
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.29320313
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.27766554
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26414981
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26125647
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24580799
61	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.23856162
62	AHR_22903824_ChIP-Seq_MCF-7_Human	1.23685781
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.21087299
64	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.19058812
65	BRD4_25478319_ChIP-Seq_HGPS_Human	1.18489148
66	TP53_16413492_ChIP-PET_HCT116_Human	1.18185936
67	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.17853015
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17831073
69	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17778850
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17022326
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.16641193
72	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14606865
73	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.13755963
74	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.13515430
75	AR_20517297_ChIP-Seq_VCAP_Human	1.13301160
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13219463
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13219463
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12290086
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12027803
80	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.09749677
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.04838437
82	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.02518728
83	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01749279
84	MYC_18940864_ChIP-ChIP_HL60_Human	1.01362723
85	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01106809
86	ELF5_23300383_ChIP-Seq_T47D_Human	1.00776853
87	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.00736744
88	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00407018
89	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.00142520
90	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99339045
91	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.95708020
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95590054
93	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.95387202
94	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.94184326
95	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.94130532
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93497546
97	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.92238695
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.91970603
99	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.91918868
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91913983

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	4.79490819
2	MP0001984_abnormal_olfaction	4.12328380
3	MP0009780_abnormal_chondrocyte_physiolo	3.70652721
4	MP0002909_abnormal_adrenal_gland	3.52862208
5	MP0004043_abnormal_pH_regulation	3.40161170
6	MP0001485_abnormal_pinna_reflex	3.35445465
7	MP0002254_reproductive_system_inflammat	3.33518468
8	MP0006072_abnormal_retinal_apoptosis	2.88020799
9	MP0003011_delayed_dark_adaptation	2.69028008
10	MP0008872_abnormal_physiological_respon	2.68591396
11	MP0005394_taste/olfaction_phenotype	2.60540729
12	MP0005499_abnormal_olfactory_system	2.60540729
13	MP0000569_abnormal_digit_pigmentation	2.42634052
14	MP0008877_abnormal_DNA_methylation	2.24530718
15	MP0000427_abnormal_hair_cycle	2.18401343
16	MP0008789_abnormal_olfactory_epithelium	2.06527479
17	MP0002938_white_spotting	2.03568542
18	MP0003718_maternal_effect	2.03413557
19	MP0004381_abnormal_hair_follicle	1.99692080
20	MP0005551_abnormal_eye_electrophysiolog	1.98601496
21	MP0008057_abnormal_DNA_replication	1.94274231
22	MP0005377_hearing/vestibular/ear_phenot	1.91582269
23	MP0003878_abnormal_ear_physiology	1.91582269
24	MP0003786_premature_aging	1.87942794
25	MP0005645_abnormal_hypothalamus_physiol	1.86935441
26	MP0008995_early_reproductive_senescence	1.76537635
27	MP0005253_abnormal_eye_physiology	1.74956376
28	MP0002736_abnormal_nociception_after	1.74724399
29	MP0003172_abnormal_lysosome_physiology	1.60070985
30	MP0005332_abnormal_amino_acid	1.52612762
31	MP0000372_irregular_coat_pigmentation	1.52303177
32	MP0002090_abnormal_vision	1.52148257
33	MP0005171_absent_coat_pigmentation	1.47526557
34	MP0008007_abnormal_cellular_replicative	1.45818807
35	MP0001968_abnormal_touch/_nociception	1.43562201
36	MP0003868_abnormal_feces_composition	1.40531733
37	MP0005379_endocrine/exocrine_gland_phen	1.39344070
38	MP0005636_abnormal_mineral_homeostasis	1.28993721
39	MP0002693_abnormal_pancreas_physiology	1.27320808
40	MP0001346_abnormal_lacrimal_gland	1.25432472
41	MP0010386_abnormal_urinary_bladder	1.22572246
42	MP0005248_abnormal_Harderian_gland	1.21033738
43	MP0006036_abnormal_mitochondrial_physio	1.19549385
44	MP0005646_abnormal_pituitary_gland	1.18871847
45	MP0003806_abnormal_nucleotide_metabolis	1.18089895
46	MP0008875_abnormal_xenobiotic_pharmacok	1.15626700
47	MP0008058_abnormal_DNA_repair	1.13672571
48	MP0004019_abnormal_vitamin_homeostasis	1.13497893
49	MP0000647_abnormal_sebaceous_gland	1.12970642
50	MP0010329_abnormal_lipoprotein_level	1.10956454
51	MP0004147_increased_porphyrin_level	1.10717265
52	MP0004215_abnormal_myocardial_fiber	1.10699570
53	MP0003186_abnormal_redox_activity	1.09253960
54	MP0001666_abnormal_nutrient_absorption	1.08436151
55	MP0003693_abnormal_embryo_hatching	1.06184985
56	MP0001764_abnormal_homeostasis	1.05351805
57	MP0001970_abnormal_pain_threshold	1.05167816
58	MP0005395_other_phenotype	1.04754575
59	MP0001486_abnormal_startle_reflex	1.03153112
60	MP0004270_analgesia	1.01662166
61	MP0004885_abnormal_endolymph	1.00669382
62	MP0001756_abnormal_urination	0.98435080
63	MP0001661_extended_life_span	0.96146619
64	MP0002734_abnormal_mechanical_nocicepti	0.91673501
65	MP0009745_abnormal_behavioral_response	0.91376611
66	MP0008004_abnormal_stomach_pH	0.90765440
67	MP0002102_abnormal_ear_morphology	0.87340284
68	MP0003890_abnormal_embryonic-extraembry	0.84574841
69	MP0001529_abnormal_vocalization	0.82176814
70	MP0003646_muscle_fatigue	0.80816897
71	MP0003111_abnormal_nucleus_morphology	0.79211300
72	MP0002234_abnormal_pharynx_morphology	0.77476764
73	MP0009046_muscle_twitch	0.77434852
74	MP0003195_calcinosis	0.75977714
75	MP0000465_gastrointestinal_hemorrhage	0.75967906
76	MP0005220_abnormal_exocrine_pancreas	0.75751346
77	MP0002277_abnormal_respiratory_mucosa	0.75574216
78	MP0002557_abnormal_social/conspecific_i	0.75146681
79	MP0002160_abnormal_reproductive_system	0.74980201
80	MP0002269_muscular_atrophy	0.74280724
81	MP0010094_abnormal_chromosome_stability	0.74214685
82	MP0005275_abnormal_skin_tensile	0.74035288
83	MP0000613_abnormal_salivary_gland	0.73955247
84	MP0001765_abnormal_ion_homeostasis	0.73597507
85	MP0001944_abnormal_pancreas_morphology	0.73268354
86	MP0005310_abnormal_salivary_gland	0.73140009
87	MP0001929_abnormal_gametogenesis	0.71674707
88	MP0003787_abnormal_imprinting	0.71288759
89	MP0001963_abnormal_hearing_physiology	0.71244681
90	MP0002733_abnormal_thermal_nociception	0.70582887
91	MP0005075_abnormal_melanosome_morpholog	0.70169689
92	MP0005174_abnormal_tail_pigmentation	0.69675661
93	MP0000383_abnormal_hair_follicle	0.68999264
94	MP0005391_vision/eye_phenotype	0.66691669
95	MP0002837_dystrophic_cardiac_calcinosis	0.63898967
96	MP0002078_abnormal_glucose_homeostasis	0.63448643
97	MP0002229_neurodegeneration	0.59864994
98	MP0006292_abnormal_olfactory_placode	0.59204020
99	MP0005410_abnormal_fertilization	0.57644257
100	MP0008932_abnormal_embryonic_tissue	0.55804627

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	4.12247675
2	Hyperlipoproteinemia (HP:0010980)	4.01535166
3	Septo-optic dysplasia (HP:0100842)	3.97699015
4	Hypothermia (HP:0002045)	3.76562718
5	Congenital primary aphakia (HP:0007707)	3.68288932
6	Gait imbalance (HP:0002141)	3.62886074
7	Vaginal atresia (HP:0000148)	3.47286718
8	Genital tract atresia (HP:0001827)	3.45574479
9	Birth length less than 3rd percentile (HP:0003561)	3.28651012
10	Chronic hepatic failure (HP:0100626)	3.27305407
11	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.26094007
12	Abnormal protein N-linked glycosylation (HP:0012347)	3.26094007
13	Abnormal protein glycosylation (HP:0012346)	3.26094007
14	Abnormal glycosylation (HP:0012345)	3.26094007
15	Poor coordination (HP:0002370)	3.24934648
16	Type I transferrin isoform profile (HP:0003642)	3.20907481
17	Nephrogenic diabetes insipidus (HP:0009806)	3.12748511
18	Arterial tortuosity (HP:0005116)	3.08065706
19	Sensory axonal neuropathy (HP:0003390)	3.05593461
20	Hypoalphalipoproteinemia (HP:0003233)	3.05341158
21	Reduced antithrombin III activity (HP:0001976)	3.03283580
22	Progressive cerebellar ataxia (HP:0002073)	3.03054949
23	Enlarged penis (HP:0000040)	2.94475833
24	Proximal tubulopathy (HP:0000114)	2.88908991
25	Hypoproteinemia (HP:0003075)	2.85132362
26	Attenuation of retinal blood vessels (HP:0007843)	2.79376498
27	Breast carcinoma (HP:0003002)	2.72296579
28	Aplasia/Hypoplasia of the lens (HP:0008063)	2.66884685
29	Symptomatic seizures (HP:0011145)	2.64233114
30	Asplenia (HP:0001746)	2.63310922
31	Bony spicule pigmentary retinopathy (HP:0007737)	2.59149523
32	Renal Fanconi syndrome (HP:0001994)	2.57146273
33	Optic nerve hypoplasia (HP:0000609)	2.53941981
34	Vascular tortuosity (HP:0004948)	2.53127034
35	Hip dysplasia (HP:0001385)	2.50008601
36	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.42942901
37	Hypolipoproteinemia (HP:0010981)	2.41329783
38	Disproportionate short-trunk short stature (HP:0003521)	2.35284599
39	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.30090137
40	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.28675619
41	Exotropia (HP:0000577)	2.26358799
42	Ependymoma (HP:0002888)	2.25892575
43	Acute encephalopathy (HP:0006846)	2.22581881
44	Congenital, generalized hypertrichosis (HP:0004540)	2.20652813
45	Hypoplastic pelvis (HP:0008839)	2.20193073
46	Abolished electroretinogram (ERG) (HP:0000550)	2.20125696
47	Abnormal pancreas size (HP:0012094)	2.19296610
48	Abnormality of vitamin metabolism (HP:0100508)	2.17670683
49	Abnormal hair whorl (HP:0010721)	2.17468135
50	Hypomagnesemia (HP:0002917)	2.16360096
51	Abnormality of methionine metabolism (HP:0010901)	2.15432793
52	Gaze-evoked nystagmus (HP:0000640)	2.13880921
53	Broad foot (HP:0001769)	2.13617106
54	Colon cancer (HP:0003003)	2.12934031
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.12576540
56	Septate vagina (HP:0001153)	2.09751565
57	Aqueductal stenosis (HP:0002410)	2.09266820
58	Hypoplasia of the odontoid process (HP:0003311)	2.08970622
59	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.07198343
60	Polydipsia (HP:0001959)	2.04700425
61	Abnormal drinking behavior (HP:0030082)	2.04700425
62	Progressive inability to walk (HP:0002505)	2.04503499
63	Neoplasm of the oral cavity (HP:0100649)	2.02648155
64	Hypoplasia of the fovea (HP:0007750)	2.01638234
65	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.01638234
66	Abnormality of vitamin B metabolism (HP:0004340)	2.01445551
67	Neoplasm of the adrenal gland (HP:0100631)	1.99475882
68	Methylmalonic acidemia (HP:0002912)	1.98524226
69	Molar tooth sign on MRI (HP:0002419)	1.97746993
70	Abnormality of midbrain morphology (HP:0002418)	1.97746993
71	Albinism (HP:0001022)	1.96474669
72	Absent septum pellucidum (HP:0001331)	1.94453297
73	Rectovaginal fistula (HP:0000143)	1.92967593
74	Rectal fistula (HP:0100590)	1.92967593
75	Methylmalonic aciduria (HP:0012120)	1.90154777
76	Pancreatic fibrosis (HP:0100732)	1.89842379
77	Vaginal fistula (HP:0004320)	1.87753627
78	Generalized hypopigmentation (HP:0007513)	1.87235437
79	Carpal bone hypoplasia (HP:0001498)	1.86906552
80	Neoplasm of the adrenal cortex (HP:0100641)	1.85407072
81	Hyperaldosteronism (HP:0000859)	1.84950547
82	Barrel-shaped chest (HP:0001552)	1.84889035
83	Tongue fasciculations (HP:0001308)	1.84196627
84	Soft skin (HP:0000977)	1.84122756
85	Pendular nystagmus (HP:0012043)	1.83953111
86	Acute necrotizing encephalopathy (HP:0006965)	1.83913330
87	Severe muscular hypotonia (HP:0006829)	1.83712312
88	Degeneration of anterior horn cells (HP:0002398)	1.81999704
89	Abnormality of the anterior horn cell (HP:0006802)	1.81999704
90	Left ventricular hypertrophy (HP:0001712)	1.81447558
91	Abnormality of endocrine pancreas physiology (HP:0012093)	1.81395541
92	Abnormality of the pancreatic islet cells (HP:0006476)	1.81395541
93	True hermaphroditism (HP:0010459)	1.80543434
94	Villous atrophy (HP:0011473)	1.79665665
95	Abnormality of small intestinal villus morphology (HP:0011472)	1.79665665
96	Palpitations (HP:0001962)	1.78530931
97	Abnormality of the astrocytes (HP:0100707)	1.78409559
98	Astrocytoma (HP:0009592)	1.78409559
99	Progressive macrocephaly (HP:0004481)	1.77398540
100	Prolonged QT interval (HP:0001657)	1.73405891

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	5.66418318
2	WNK3	5.40193313
3	STK39	4.66936919
4	MST4	4.57103807
5	OXSR1	3.77154645
6	PDK2	3.74877392
7	FRK	3.66338401
8	MKNK2	2.31748079
9	VRK2	2.18843472
10	FER	2.15540940
11	ACVR1B	2.05243852
12	TGFBR2	2.03173545
13	PAK3	1.81486305
14	STK38L	1.77657450
15	MAP3K12	1.69019089
16	TAF1	1.65001257
17	NUAK1	1.54172737
18	TRPM7	1.50047721
19	FGFR1	1.48760796
20	BUB1	1.39287170
21	GRK1	1.38554306
22	PRKCI	1.36930909
23	FGFR2	1.35161582
24	BMPR1B	1.29786551
25	PLK2	1.22776288
26	MKNK1	1.22376906
27	PLK3	1.09027393
28	AKT3	1.07193351
29	TSSK6	1.07178831
30	BRD4	0.96609006
31	PINK1	0.94334944
32	SGK2	0.93752663
33	NEK1	0.89779547
34	TRIM28	0.89656759
35	INSRR	0.89326828
36	ZAK	0.86948790
37	EIF2AK1	0.84218381
38	STK10	0.82268491
39	ERBB4	0.80876026
40	ADRBK2	0.79898703
41	MAPKAPK5	0.77578750
42	CDC7	0.72882691
43	SGK223	0.70747038
44	SGK494	0.70747038
45	NEK6	0.69952199
46	BMX	0.68387481
47	PRKCE	0.67798538
48	PDGFRB	0.67215676
49	JAK1	0.64800492
50	EIF2AK2	0.63563217
51	SGK3	0.61468401
52	NME1	0.59964960
53	PTK2	0.59832223
54	TTK	0.59673063
55	MAP4K2	0.57731173
56	MAPKAPK3	0.56961352
57	BRSK2	0.55211669
58	TNIK	0.54768374
59	PHKG1	0.53325613
60	PHKG2	0.53325613
61	MAP2K1	0.53280597
62	STK38	0.52611977
63	CSNK1G1	0.50736518
64	VRK1	0.49772870
65	CSNK1A1L	0.49259450
66	ALK	0.46719577
67	PRKAA2	0.45231554
68	TGFBR1	0.41816803
69	STK3	0.36392042
70	LRRK2	0.34731392
71	ADRBK1	0.34702590
72	EEF2K	0.34694609
73	STK24	0.33426752
74	MELK	0.33016259
75	CAMK4	0.32943226
76	GSK3A	0.32932990
77	CASK	0.31936984
78	MAP3K5	0.29992864
79	PLK1	0.28079138
80	MUSK	0.27401136
81	TNK2	0.27352175
82	NTRK2	0.26769040
83	PRKCG	0.25852075
84	CSNK1G3	0.25014424
85	NLK	0.24187819
86	ATR	0.22487129
87	PBK	0.21809882
88	IRAK1	0.21779674
89	GRK5	0.21688410
90	PTK2B	0.21306517
91	DYRK2	0.20734662
92	CHUK	0.20016360
93	ERBB3	0.19693746
94	MAP3K4	0.19143491
95	HIPK2	0.18545472
96	PRKCQ	0.18345924
97	ABL1	0.18227210
98	AKT2	0.17611637
99	CSNK1G2	0.16852156
100	DAPK2	0.16340641

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	6.65863329
2	Protein export_Homo sapiens_hsa03060	3.93320409
3	Propanoate metabolism_Homo sapiens_hsa00640	2.56756137
4	RNA polymerase_Homo sapiens_hsa03020	2.48091036
5	Fatty acid elongation_Homo sapiens_hsa00062	2.37724949
6	Oxidative phosphorylation_Homo sapiens_hsa00190	1.99994901
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.97814942
8	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.97740654
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.95348601
10	Proteasome_Homo sapiens_hsa03050	1.89398716
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.81881782
12	Butanoate metabolism_Homo sapiens_hsa00650	1.78648409
13	Homologous recombination_Homo sapiens_hsa03440	1.70302453
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60010811
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.58946889
16	Collecting duct acid secretion_Homo sapiens_hsa04966	1.57441769
17	One carbon pool by folate_Homo sapiens_hsa00670	1.56070728
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.51633402
19	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.51022013
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.50046341
21	Folate biosynthesis_Homo sapiens_hsa00790	1.45799476
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.39449222
23	Pyruvate metabolism_Homo sapiens_hsa00620	1.39186853
24	Peroxisome_Homo sapiens_hsa04146	1.39178403
25	Glutathione metabolism_Homo sapiens_hsa00480	1.36672999
26	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.35543704
27	Parkinsons disease_Homo sapiens_hsa05012	1.32681022
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.31519333
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.28454166
30	Phototransduction_Homo sapiens_hsa04744	1.28112156
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.28063857
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.27827861
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.27214152
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20632160
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.16919282
36	Huntingtons disease_Homo sapiens_hsa05016	1.14060806
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.13204170
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12139850
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11582003
40	Lysine degradation_Homo sapiens_hsa00310	1.06338262
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.06058529
42	Retinol metabolism_Homo sapiens_hsa00830	1.03194262
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01186504
44	Circadian rhythm_Homo sapiens_hsa04710	0.98895468
45	Insulin secretion_Homo sapiens_hsa04911	0.96300136
46	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.92361382
47	Mismatch repair_Homo sapiens_hsa03430	0.91719058
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91490485
49	Purine metabolism_Homo sapiens_hsa00230	0.91060994
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89926468
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88990978
52	Fatty acid degradation_Homo sapiens_hsa00071	0.88203015
53	Alzheimers disease_Homo sapiens_hsa05010	0.87285196
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.86111728
55	Sulfur metabolism_Homo sapiens_hsa00920	0.85685631
56	Metabolic pathways_Homo sapiens_hsa01100	0.84964042
57	Mineral absorption_Homo sapiens_hsa04978	0.82051232
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81887676
59	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81387775
60	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.78338600
61	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.77319524
62	Oocyte meiosis_Homo sapiens_hsa04114	0.74583869
63	RNA degradation_Homo sapiens_hsa03018	0.74386871
64	Adherens junction_Homo sapiens_hsa04520	0.74093163
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69192381
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69189287
67	Vibrio cholerae infection_Homo sapiens_hsa05110	0.67568649
68	Arginine biosynthesis_Homo sapiens_hsa00220	0.64956653
69	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64253068
70	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.58274604
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57987411
72	Histidine metabolism_Homo sapiens_hsa00340	0.56294258
73	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56255725
74	Regulation of autophagy_Homo sapiens_hsa04140	0.55264265
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54361615
76	RNA transport_Homo sapiens_hsa03013	0.52474108
77	Basal transcription factors_Homo sapiens_hsa03022	0.51517685
78	p53 signaling pathway_Homo sapiens_hsa04115	0.51507324
79	Caffeine metabolism_Homo sapiens_hsa00232	0.51387765
80	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.51258266
81	Non-homologous end-joining_Homo sapiens_hsa03450	0.47312942
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.46224434
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.44827439
84	ABC transporters_Homo sapiens_hsa02010	0.42889061
85	Carbon metabolism_Homo sapiens_hsa01200	0.42207611
86	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.41867916
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41691981
88	Cardiac muscle contraction_Homo sapiens_hsa04260	0.41422390
89	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.39976303
90	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39912157
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39560353
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34666389
93	Pancreatic secretion_Homo sapiens_hsa04972	0.34410831
94	Lysosome_Homo sapiens_hsa04142	0.32746083
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.32166865
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.30857283
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.30222666
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30102745
99	Olfactory transduction_Homo sapiens_hsa04740	0.29082469
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.29078983

ENO1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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