ENO1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)8.51954756
2neuron fate determination (GO:0048664)6.73410581
3kinetochore assembly (GO:0051382)6.62664407
4kinetochore organization (GO:0051383)6.34512543
5behavioral response to nicotine (GO:0035095)6.01267019
6metaphase plate congression (GO:0051310)5.48913895
7ventricular cardiac muscle cell development (GO:0055015)5.42224357
8mitotic metaphase plate congression (GO:0007080)5.17319058
9protein localization to kinetochore (GO:0034501)5.04243840
10microtubule depolymerization (GO:0007019)4.84393033
11establishment of chromosome localization (GO:0051303)4.70643146
12protein localization to chromosome, centromeric region (GO:0071459)4.41762433
13sister chromatid segregation (GO:0000819)4.20442664
14mitotic sister chromatid segregation (GO:0000070)4.18944383
15DNA ligation (GO:0006266)4.15694101
16spermatid nucleus differentiation (GO:0007289)4.15056563
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.11927007
18neuron fate specification (GO:0048665)4.05468397
19mitotic chromosome condensation (GO:0007076)3.85298159
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74849676
21DNA topological change (GO:0006265)3.71263325
22chromosome condensation (GO:0030261)3.51234368
23regulation of chromatin binding (GO:0035561)3.50412513
24chromatin remodeling at centromere (GO:0031055)3.48707961
25protein K6-linked ubiquitination (GO:0085020)3.41788706
26spindle checkpoint (GO:0031577)3.39430442
27histone H2A acetylation (GO:0043968)3.37552436
28CENP-A containing nucleosome assembly (GO:0034080)3.33537471
29microtubule polymerization or depolymerization (GO:0031109)3.30925875
30positive regulation of epidermal cell differentiation (GO:0045606)3.27409734
31mitotic spindle checkpoint (GO:0071174)3.24286352
32DNA replication checkpoint (GO:0000076)3.20874726
33regulation of spindle organization (GO:0090224)3.18631898
34ATP synthesis coupled proton transport (GO:0015986)3.15710491
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15710491
36protein localization to chromosome (GO:0034502)3.01687062
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.01467729
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.01467729
39regulation of translation, ncRNA-mediated (GO:0045974)3.01467729
40retinal cone cell development (GO:0046549)2.99864894
41regulation of mitotic spindle organization (GO:0060236)2.97775863
42negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94930058
43negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94930058
44negative regulation of mitotic sister chromatid separation (GO:2000816)2.94930058
45negative regulation of sister chromatid segregation (GO:0033046)2.94930058
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94930058
47presynaptic membrane assembly (GO:0097105)2.94595853
48DNA unwinding involved in DNA replication (GO:0006268)2.90747555
49negative regulation of chromosome segregation (GO:0051985)2.90731950
50spindle assembly checkpoint (GO:0071173)2.89748332
51mitotic spindle assembly checkpoint (GO:0007094)2.89476833
52chromosome segregation (GO:0007059)2.87568084
53chaperone-mediated protein transport (GO:0072321)2.87277701
54regulation of chromosome segregation (GO:0051983)2.81625102
55DNA damage response, detection of DNA damage (GO:0042769)2.81394476
56positive regulation of cardiac muscle tissue growth (GO:0055023)2.80006960
57maturation of SSU-rRNA (GO:0030490)2.79006667
58DNA packaging (GO:0006323)2.77171836
59cullin deneddylation (GO:0010388)2.76606449
60positive regulation of cardiac muscle cell differentiation (GO:2000727)2.73031088
61epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.72301235
62lateral sprouting from an epithelium (GO:0060601)2.72035667
63positive regulation of cardiac muscle tissue development (GO:0055025)2.70516907
64protein deneddylation (GO:0000338)2.69444305
65positive regulation of cardiac muscle cell proliferation (GO:0060045)2.69419776
66histone exchange (GO:0043486)2.66504182
67mitotic nuclear envelope disassembly (GO:0007077)2.62169839
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61471925
69pyrimidine nucleobase catabolic process (GO:0006208)2.60735454
70mitochondrial respiratory chain complex assembly (GO:0033108)2.60674293
71regulation of development, heterochronic (GO:0040034)2.59983693
72protein complex biogenesis (GO:0070271)2.57975688
73regulation of sister chromatid segregation (GO:0033045)2.57779660
74regulation of mitotic sister chromatid separation (GO:0010965)2.57779660
75regulation of mitotic sister chromatid segregation (GO:0033047)2.57779660
76regulation of timing of cell differentiation (GO:0048505)2.57642938
77postsynaptic membrane organization (GO:0001941)2.55960392
78regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55531623
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.55531623
80ATP-dependent chromatin remodeling (GO:0043044)2.55006458
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.54207052
82NADH dehydrogenase complex assembly (GO:0010257)2.54207052
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54207052
84negative regulation of mitosis (GO:0045839)2.53501537
85positive regulation of neuroblast proliferation (GO:0002052)2.52096633
86regulation of DNA endoreduplication (GO:0032875)2.50928009
87DNA replication-independent nucleosome organization (GO:0034724)2.47854383
88DNA replication-independent nucleosome assembly (GO:0006336)2.47854383
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.46627200
90cranial nerve morphogenesis (GO:0021602)2.46558967
91negative regulation of nuclear division (GO:0051784)2.43966212
92cell fate specification (GO:0001708)2.41779375
93negative regulation of cell division (GO:0051782)2.41129199
94positive regulation of catecholamine secretion (GO:0033605)2.41006486
95peptidyl-histidine modification (GO:0018202)2.40061362
96negative regulation of meiosis (GO:0045835)2.39574385
97regulation of cardiac muscle cell proliferation (GO:0060043)2.37378036
98cardiac muscle cell development (GO:0055013)2.35943996
99positive regulation of heart growth (GO:0060421)2.35071809
100regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.34742506

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.27077640
2FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.01424505
3E2F7_22180533_ChIP-Seq_HELA_Human3.95053807
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.70923240
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.66954020
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.48087480
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.42918684
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35742747
9EZH2_22144423_ChIP-Seq_EOC_Human3.09504316
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64837488
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.59578041
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55580839
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55034566
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.45999780
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.30982758
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.30755888
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.28958657
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23205983
19ELK1_19687146_ChIP-ChIP_HELA_Human2.22269835
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89333172
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.88741304
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.87485665
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81661690
24TTF2_22483619_ChIP-Seq_HELA_Human1.80543485
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77481199
26FUS_26573619_Chip-Seq_HEK293_Human1.76448452
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72627361
28AR_21909140_ChIP-Seq_LNCAP_Human1.71649603
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66552171
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66217359
31XRN2_22483619_ChIP-Seq_HELA_Human1.65611644
32EWS_26573619_Chip-Seq_HEK293_Human1.64563429
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63547499
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60390806
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.60153195
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59791635
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.58577752
38ZNF274_21170338_ChIP-Seq_K562_Hela1.55313800
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.55285441
40VDR_22108803_ChIP-Seq_LS180_Human1.53354005
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44551829
42DCP1A_22483619_ChIP-Seq_HELA_Human1.42807300
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.41728609
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41444156
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40939772
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40027543
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37082203
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33720237
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31374235
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30564630
51GBX2_23144817_ChIP-Seq_PC3_Human1.27369750
52VDR_23849224_ChIP-Seq_CD4+_Human1.26237007
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21160780
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20620865
55P300_19829295_ChIP-Seq_ESCs_Human1.19697781
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18325559
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.17368482
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14758195
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.14547701
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14068285
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13993188
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.12398987
63TAF15_26573619_Chip-Seq_HEK293_Human1.12298812
64FOXP3_21729870_ChIP-Seq_TREG_Human1.12184637
65RNF2_27304074_Chip-Seq_NSC_Mouse1.11352244
66MYC_18940864_ChIP-ChIP_HL60_Human1.10975188
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10605073
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08986683
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07703432
70FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06755242
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06308999
72IRF1_19129219_ChIP-ChIP_H3396_Human1.06078114
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05041707
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04462729
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.03639533
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.03364453
77NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99599148
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97324387
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96762137
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92283367
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91801006
82SOX9_26525672_Chip-Seq_HEART_Mouse0.88878323
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88516979
84POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86230505
85SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85871269
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85104308
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85029021
88GABP_19822575_ChIP-Seq_HepG2_Human0.84974712
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84912441
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84892484
91CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84264049
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83624239
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83624239
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83624239
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83236106
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82089660
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81821052
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81646081
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81608755
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81048286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex4.82527668
2MP0001986_abnormal_taste_sensitivity3.45853340
3MP0001529_abnormal_vocalization3.30311601
4MP0008789_abnormal_olfactory_epithelium2.73984325
5MP0003111_abnormal_nucleus_morphology2.63314541
6MP0010386_abnormal_urinary_bladder2.52047177
7MP0000537_abnormal_urethra_morphology2.49211386
8MP0010030_abnormal_orbit_morphology2.32557568
9MP0010094_abnormal_chromosome_stability2.26910284
10MP0005394_taste/olfaction_phenotype2.22006250
11MP0005499_abnormal_olfactory_system2.22006250
12MP0003693_abnormal_embryo_hatching2.20109669
13MP0003077_abnormal_cell_cycle2.06182918
14MP0006072_abnormal_retinal_apoptosis2.02680457
15MP0002102_abnormal_ear_morphology2.01600045
16MP0009053_abnormal_anal_canal2.00005403
17MP0003283_abnormal_digestive_organ1.98782709
18MP0003315_abnormal_perineum_morphology1.97496552
19MP0000049_abnormal_middle_ear1.94283691
20MP0008932_abnormal_embryonic_tissue1.91256302
21MP0000566_synostosis1.87306686
22MP0000372_irregular_coat_pigmentation1.83419292
23MP0000516_abnormal_urinary_system1.80610361
24MP0005367_renal/urinary_system_phenotyp1.80610361
25MP0003136_yellow_coat_color1.74494949
26MP0002938_white_spotting1.72250701
27MP0002234_abnormal_pharynx_morphology1.70968785
28MP0003941_abnormal_skin_development1.69620170
29MP0005623_abnormal_meninges_morphology1.69073606
30MP0001984_abnormal_olfaction1.65101900
31MP0004270_analgesia1.60483811
32MP0005187_abnormal_penis_morphology1.60433546
33MP0003567_abnormal_fetal_cardiomyocyte1.56426582
34MP0004957_abnormal_blastocyst_morpholog1.52888798
35MP0003937_abnormal_limbs/digits/tail_de1.52329597
36MP0001542_abnormal_bone_strength1.48291053
37MP0000538_abnormal_urinary_bladder1.44976424
38MP0003755_abnormal_palate_morphology1.43060910
39MP0006292_abnormal_olfactory_placode1.42575912
40MP0009379_abnormal_foot_pigmentation1.40266454
41MP0002233_abnormal_nose_morphology1.39868189
42MP0006276_abnormal_autonomic_nervous1.36384271
43MP0005253_abnormal_eye_physiology1.34453622
44MP0003385_abnormal_body_wall1.33088015
45MP0001293_anophthalmia1.30180021
46MP0000778_abnormal_nervous_system1.28646028
47MP0002160_abnormal_reproductive_system1.26873408
48MP0005257_abnormal_intraocular_pressure1.26697400
49MP0000490_abnormal_crypts_of1.25833236
50MP0005408_hypopigmentation1.23704145
51MP0003938_abnormal_ear_development1.23553771
52MP0002697_abnormal_eye_size1.23229228
53MP0005171_absent_coat_pigmentation1.22685069
54MP0002177_abnormal_outer_ear1.19578655
55MP0009250_abnormal_appendicular_skeleto1.18578747
56MP0001286_abnormal_eye_development1.18310506
57MP0008058_abnormal_DNA_repair1.16235908
58MP0002751_abnormal_autonomic_nervous1.07610541
59MP0000428_abnormal_craniofacial_morphol1.06827881
60MP0001299_abnormal_eye_distance/1.06567162
61MP0000534_abnormal_ureter_morphology1.06470624
62MP0002095_abnormal_skin_pigmentation1.06228773
63MP0005377_hearing/vestibular/ear_phenot1.05065242
64MP0003878_abnormal_ear_physiology1.05065242
65MP0005391_vision/eye_phenotype1.03437570
66MP0005423_abnormal_somatic_nervous1.03248304
67MP0000026_abnormal_inner_ear1.02614538
68MP0001502_abnormal_circadian_rhythm1.02336843
69MP0004142_abnormal_muscle_tone1.00951741
70MP0005197_abnormal_uvea_morphology1.00269057
71MP0002184_abnormal_innervation1.00042589
72MP0003942_abnormal_urinary_system0.95203533
73MP0001486_abnormal_startle_reflex0.94714881
74MP0003861_abnormal_nervous_system0.93021942
75MP0000631_abnormal_neuroendocrine_gland0.92002293
76MP0002734_abnormal_mechanical_nocicepti0.91685843
77MP0005083_abnormal_biliary_tract0.91263240
78MP0005248_abnormal_Harderian_gland0.81995438
79MP0002752_abnormal_somatic_nervous0.81825370
80MP0002109_abnormal_limb_morphology0.80973082
81MP0002272_abnormal_nervous_system0.80823117
82MP0005551_abnormal_eye_electrophysiolog0.80790878
83MP0005193_abnormal_anterior_eye0.80116834
84MP0002653_abnormal_ependyma_morphology0.79274597
85MP0003935_abnormal_craniofacial_develop0.79134417
86MP0002081_perinatal_lethality0.76265522
87MP0003119_abnormal_digestive_system0.76156448
88MP0000762_abnormal_tongue_morphology0.76116148
89MP0004133_heterotaxia0.76030267
90MP0005645_abnormal_hypothalamus_physiol0.74903643
91MP0004811_abnormal_neuron_physiology0.74702686
92MP0001340_abnormal_eyelid_morphology0.73548352
93MP0002932_abnormal_joint_morphology0.72586434
94MP0004197_abnormal_fetal_growth/weight/0.72548409
95MP0005389_reproductive_system_phenotype0.70472514
96MP0003880_abnormal_central_pattern0.68304248
97MP0002084_abnormal_developmental_patter0.67300252
98MP0009780_abnormal_chondrocyte_physiolo0.66985857
99MP0002876_abnormal_thyroid_physiology0.66863252
100MP0005195_abnormal_posterior_eye0.66259866

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)5.19484428
2Type 2 muscle fiber atrophy (HP:0003554)4.31659021
311 pairs of ribs (HP:0000878)3.90544280
4Muscle fiber atrophy (HP:0100295)3.57232395
5Long clavicles (HP:0000890)3.41671210
6Limb hypertonia (HP:0002509)3.35986761
7Short 4th metacarpal (HP:0010044)3.31572474
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.31572474
9Increased hepatocellular lipid droplets (HP:0006565)3.17793303
10Cortical dysplasia (HP:0002539)2.98390339
11Renal Fanconi syndrome (HP:0001994)2.87252712
12Abnormal lung lobation (HP:0002101)2.81011781
13Lipid accumulation in hepatocytes (HP:0006561)2.74220108
14Hyperventilation (HP:0002883)2.56883627
15Gonadotropin excess (HP:0000837)2.55123766
16Rib fusion (HP:0000902)2.54577940
17Abnormality of the 4th metacarpal (HP:0010012)2.52396739
18Abnormality of the calcaneus (HP:0008364)2.51459145
19Thyroid-stimulating hormone excess (HP:0002925)2.48894538
20Increased intramyocellular lipid droplets (HP:0012240)2.45832255
21Hepatocellular necrosis (HP:0001404)2.40729013
22Abnormality of the labia minora (HP:0012880)2.26691211
23Hepatic necrosis (HP:0002605)2.20364733
24Mitochondrial inheritance (HP:0001427)2.20303355
25Colon cancer (HP:0003003)2.20122202
26Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.14000899
27Short 1st metacarpal (HP:0010034)2.14000899
28Mesomelia (HP:0003027)2.13557351
29Ectopic kidney (HP:0000086)2.07822243
30Cystic hygroma (HP:0000476)2.06381277
31Increased CSF lactate (HP:0002490)2.05295839
32Exertional dyspnea (HP:0002875)2.04639113
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96802158
34Adrenal hypoplasia (HP:0000835)1.95809373
35Aplasia/Hypoplasia of the sternum (HP:0006714)1.94430822
36Nephrogenic diabetes insipidus (HP:0009806)1.93899511
37Tented upper lip vermilion (HP:0010804)1.93291982
38Abnormality of the 1st metacarpal (HP:0010009)1.93220549
39Respiratory difficulties (HP:0002880)1.91212305
40Absent eyelashes (HP:0000561)1.91023950
41Drooling (HP:0002307)1.89287022
42Abnormality of the neuromuscular junction (HP:0003398)1.88194424
43Fatigable weakness (HP:0003473)1.88194424
44Supernumerary spleens (HP:0009799)1.85555511
45Partial agenesis of the corpus callosum (HP:0001338)1.83335722
46Carpal bone hypoplasia (HP:0001498)1.80245414
47Poor eye contact (HP:0000817)1.79391065
48Missing ribs (HP:0000921)1.78787935
49Abnormality of macular pigmentation (HP:0008002)1.78414949
50Increased muscle lipid content (HP:0009058)1.78349799
51Respiratory insufficiency due to muscle weakness (HP:0002747)1.78272881
52Absent eyebrow (HP:0002223)1.78013755
53Concave nail (HP:0001598)1.77368454
54Astigmatism (HP:0000483)1.77032003
55Postaxial hand polydactyly (HP:0001162)1.76783624
56Pancreatic islet-cell hyperplasia (HP:0004510)1.76010560
57Meckel diverticulum (HP:0002245)1.75109731
58Esophageal atresia (HP:0002032)1.74842551
59Pancreatic fibrosis (HP:0100732)1.74072548
60Cutaneous finger syndactyly (HP:0010554)1.73519736
61Amniotic constriction ring (HP:0009775)1.73251745
62Abnormality of placental membranes (HP:0011409)1.73251745
63Bifid tongue (HP:0010297)1.72446359
64Congenital primary aphakia (HP:0007707)1.71847552
65Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71451148
66Shawl scrotum (HP:0000049)1.67820173
67Abnormality of chromosome segregation (HP:0002916)1.67731085
68Decreased skull ossification (HP:0004331)1.65644845
69Severe visual impairment (HP:0001141)1.64185123
70Postaxial foot polydactyly (HP:0001830)1.63873129
71Follicular hyperkeratosis (HP:0007502)1.63808361
72Patellar aplasia (HP:0006443)1.63725683
73Morphological abnormality of the middle ear (HP:0008609)1.63305167
74Excessive salivation (HP:0003781)1.61945180
75Vaginal atresia (HP:0000148)1.61788525
76Gait imbalance (HP:0002141)1.61477670
77Abnormal mitochondria in muscle tissue (HP:0008316)1.61032370
78High anterior hairline (HP:0009890)1.60951571
79Short tibia (HP:0005736)1.60917375
80Metaphyseal cupping (HP:0003021)1.60503644
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.60428648
82Convex nasal ridge (HP:0000444)1.58886739
83Short 5th finger (HP:0009237)1.57620245
84Aplasia/Hypoplasia of the brainstem (HP:0007362)1.57160056
85Hypoplasia of the brainstem (HP:0002365)1.57160056
86Genital tract atresia (HP:0001827)1.55772403
87Abnormal number of erythroid precursors (HP:0012131)1.55172055
88Narrow forehead (HP:0000341)1.54701041
89Aplasia/Hypoplasia of the patella (HP:0006498)1.54401561
90Chin dimple (HP:0010751)1.54222768
91Abnormality of the 2nd finger (HP:0004100)1.53558214
92Abnormality of the ileum (HP:0001549)1.53432908
93Acute necrotizing encephalopathy (HP:0006965)1.53057324
94Open mouth (HP:0000194)1.52149093
95Cerebellar hypoplasia (HP:0001321)1.51385776
96Esotropia (HP:0000565)1.51296681
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.49306281
98Weak cry (HP:0001612)1.48946244
99Dandy-Walker malformation (HP:0001305)1.47101649
100Oligodactyly (HP:0012165)1.46625993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.71961198
2BUB14.24440229
3WEE12.86877296
4MUSK2.81646816
5PBK2.75080454
6MAP3K42.65440414
7NUAK12.52038876
8TTK2.45605650
9TLK12.43154476
10VRK22.38453479
11SRPK12.35461230
12TRIM282.12937727
13PDK22.09980637
14TAF12.04916012
15EPHB22.00540015
16PLK31.97931338
17MAP2K71.97682430
18DYRK31.90770643
19RPS6KA41.87771357
20EIF2AK11.81923571
21NEK11.62890737
22CDC71.58694021
23MINK11.51278829
24DYRK21.40564030
25ERBB31.33858783
26NME21.30435116
27AURKB1.27980564
28FLT31.23268139
29CSNK1A1L1.18368210
30PLK11.17258432
31ZAK1.11908575
32CSNK1G31.11657295
33EIF2AK21.10779840
34WNK31.09105774
35BCR1.08654555
36MARK11.07760011
37TSSK61.07607301
38VRK11.04167331
39MKNK11.04108146
40CCNB10.95694977
41CDK30.95666885
42PIM20.95499221
43MKNK20.93081663
44BRSK20.92702326
45CSNK1G10.90217066
46CASK0.88377570
47CSNK1G20.86713376
48STK160.82769787
49BRSK10.79782674
50CLK10.77523019
51ATR0.73903976
52PLK20.71161401
53CDK70.67972672
54CAMK1D0.67775968
55PAK30.67678358
56NEK20.64525029
57NTRK20.64397594
58STK38L0.64271256
59CHEK20.64249776
60NME10.64059293
61AKT30.63021902
62MAP4K20.62169735
63BCKDK0.61611194
64MAPK130.60434309
65CDK80.58614098
66MAP2K40.57282960
67STK390.56108833
68CHEK10.54174341
69AURKA0.52655606
70SGK20.51503769
71TESK20.51294085
72OBSCN0.49447069
73AKT20.48131572
74PRKCE0.47940986
75LIMK10.46420230
76CAMK2G0.45774722
77RPS6KA10.45559830
78CAMK1G0.45478726
79CDK140.44694599
80CSNK2A10.43813763
81CAMK2B0.43325059
82PAK40.40126555
83ADRBK20.39667434
84GSK3A0.38428474
85PKN10.37315496
86PRKCG0.36908452
87CDK10.36756958
88PNCK0.35260480
89SGK2230.34137832
90SGK4940.34137832
91CSNK1D0.32464540
92PASK0.31806239
93CAMK2A0.30002278
94EIF2AK30.29785127
95CAMK2D0.28316735
96MELK0.27009539
97PINK10.26673702
98PRKG10.26521396
99ERBB20.26342172
100ATM0.26204203

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.55372513
2DNA replication_Homo sapiens_hsa030303.43192678
3Oxidative phosphorylation_Homo sapiens_hsa001903.32469511
4Proteasome_Homo sapiens_hsa030502.95851978
5Ribosome_Homo sapiens_hsa030102.70095948
6Parkinsons disease_Homo sapiens_hsa050122.67231218
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63862577
8Basal transcription factors_Homo sapiens_hsa030222.54236117
9Cell cycle_Homo sapiens_hsa041102.53942039
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46005021
11Huntingtons disease_Homo sapiens_hsa050162.29914465
12Fanconi anemia pathway_Homo sapiens_hsa034602.29245395
13Homologous recombination_Homo sapiens_hsa034402.27523637
14Nucleotide excision repair_Homo sapiens_hsa034202.16735962
15Selenocompound metabolism_Homo sapiens_hsa004502.14110734
16Spliceosome_Homo sapiens_hsa030402.11846999
17Base excision repair_Homo sapiens_hsa034101.96097121
18Alzheimers disease_Homo sapiens_hsa050101.92977706
19Non-homologous end-joining_Homo sapiens_hsa034501.92101811
20Oocyte meiosis_Homo sapiens_hsa041141.85256294
21Basal cell carcinoma_Homo sapiens_hsa052171.81776602
22RNA transport_Homo sapiens_hsa030131.79679990
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66967761
24p53 signaling pathway_Homo sapiens_hsa041151.65563459
25Protein export_Homo sapiens_hsa030601.65485931
26Pyrimidine metabolism_Homo sapiens_hsa002401.57514809
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52736978
28Folate biosynthesis_Homo sapiens_hsa007901.52054961
29Cardiac muscle contraction_Homo sapiens_hsa042601.51251182
30One carbon pool by folate_Homo sapiens_hsa006701.41201675
31Nicotine addiction_Homo sapiens_hsa050331.40840285
32RNA degradation_Homo sapiens_hsa030181.38693627
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30690208
34Hedgehog signaling pathway_Homo sapiens_hsa043401.30021881
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29260164
36RNA polymerase_Homo sapiens_hsa030201.23952087
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18593646
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08054413
39Purine metabolism_Homo sapiens_hsa002301.04601343
40mRNA surveillance pathway_Homo sapiens_hsa030150.98509060
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95877037
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94355903
43Pyruvate metabolism_Homo sapiens_hsa006200.88778021
44Wnt signaling pathway_Homo sapiens_hsa043100.88393381
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81787935
46Hippo signaling pathway_Homo sapiens_hsa043900.81701209
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.77039589
48Axon guidance_Homo sapiens_hsa043600.74193094
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72849964
50TGF-beta signaling pathway_Homo sapiens_hsa043500.70498259
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68368083
52Fatty acid elongation_Homo sapiens_hsa000620.66892283
53Small cell lung cancer_Homo sapiens_hsa052220.65007404
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61054018
55Phototransduction_Homo sapiens_hsa047440.59687486
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59041347
57Steroid biosynthesis_Homo sapiens_hsa001000.58562302
58Melanoma_Homo sapiens_hsa052180.58487139
59Glutathione metabolism_Homo sapiens_hsa004800.56287385
60Gap junction_Homo sapiens_hsa045400.56017355
61Circadian rhythm_Homo sapiens_hsa047100.52936053
62Epstein-Barr virus infection_Homo sapiens_hsa051690.52900931
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52126098
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50407751
65Olfactory transduction_Homo sapiens_hsa047400.50046026
66Notch signaling pathway_Homo sapiens_hsa043300.49534792
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49111824
68Systemic lupus erythematosus_Homo sapiens_hsa053220.47133204
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46823834
70HTLV-I infection_Homo sapiens_hsa051660.46812618
71Carbon metabolism_Homo sapiens_hsa012000.44757150
72Melanogenesis_Homo sapiens_hsa049160.44583146
73MicroRNAs in cancer_Homo sapiens_hsa052060.44167997
74Propanoate metabolism_Homo sapiens_hsa006400.43766802
75Alcoholism_Homo sapiens_hsa050340.42740223
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41696930
77Metabolic pathways_Homo sapiens_hsa011000.41044091
78ECM-receptor interaction_Homo sapiens_hsa045120.40319624
79Sulfur relay system_Homo sapiens_hsa041220.39392103
80Biosynthesis of amino acids_Homo sapiens_hsa012300.39295516
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38911479
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37682043
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.37575215
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36973171
85Dilated cardiomyopathy_Homo sapiens_hsa054140.35694048
86Lysine degradation_Homo sapiens_hsa003100.35122405
87Pathways in cancer_Homo sapiens_hsa052000.34977635
88Collecting duct acid secretion_Homo sapiens_hsa049660.33672627
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32191270
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28941357
91GABAergic synapse_Homo sapiens_hsa047270.27968351
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25165035
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24191850
94Asthma_Homo sapiens_hsa053100.21499880
95Tight junction_Homo sapiens_hsa045300.20770470
96Nitrogen metabolism_Homo sapiens_hsa009100.19571980
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.19447033
98Taste transduction_Homo sapiens_hsa047420.19055542
99Vitamin digestion and absorption_Homo sapiens_hsa049770.18600040
100Viral carcinogenesis_Homo sapiens_hsa052030.18311876

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