ENO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.27708300
2synaptic vesicle maturation (GO:0016188)6.06707259
3synaptic vesicle exocytosis (GO:0016079)5.61778642
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.56958066
5locomotory exploration behavior (GO:0035641)5.53654829
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52076814
7vocalization behavior (GO:0071625)5.37233102
8glutamate secretion (GO:0014047)5.28052327
9regulation of synaptic vesicle exocytosis (GO:2000300)5.23186272
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.11598352
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.97341514
12neuronal action potential propagation (GO:0019227)4.94790461
13regulation of glutamate receptor signaling pathway (GO:1900449)4.86136617
14neurotransmitter secretion (GO:0007269)4.75925016
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.74359191
16regulation of synaptic vesicle transport (GO:1902803)4.69831415
17protein localization to synapse (GO:0035418)4.64566160
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.50190969
19regulation of neuronal synaptic plasticity (GO:0048168)4.47381501
20pyrimidine nucleobase catabolic process (GO:0006208)4.39791255
21establishment of mitochondrion localization (GO:0051654)4.36582718
22exploration behavior (GO:0035640)4.33486948
23synaptic transmission, glutamatergic (GO:0035249)4.23567138
24neuron cell-cell adhesion (GO:0007158)4.22674684
25regulation of synapse structural plasticity (GO:0051823)4.21576605
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21026837
27glutamate receptor signaling pathway (GO:0007215)4.19845802
28neuron-neuron synaptic transmission (GO:0007270)4.18260884
29gamma-aminobutyric acid transport (GO:0015812)4.09671209
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07096338
31cerebellar granule cell differentiation (GO:0021707)4.05922333
32presynaptic membrane organization (GO:0097090)4.05787910
33cellular potassium ion homeostasis (GO:0030007)4.05128893
34presynaptic membrane assembly (GO:0097105)4.04518952
35long-term memory (GO:0007616)3.94405136
36neurotransmitter-gated ion channel clustering (GO:0072578)3.91852111
37neurotransmitter transport (GO:0006836)3.89427443
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86834464
39layer formation in cerebral cortex (GO:0021819)3.84356225
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.82880876
41proline transport (GO:0015824)3.81851625
42neuromuscular process controlling posture (GO:0050884)3.79163321
43positive regulation of membrane potential (GO:0045838)3.75887723
44cell migration in hindbrain (GO:0021535)3.74370558
45sodium ion export (GO:0071436)3.70231945
46regulation of postsynaptic membrane potential (GO:0060078)3.67885532
47nucleobase catabolic process (GO:0046113)3.67804477
48regulation of synaptic plasticity (GO:0048167)3.64866484
49regulation of neurotransmitter levels (GO:0001505)3.64328124
50dendritic spine morphogenesis (GO:0060997)3.62813573
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.62546312
52activation of protein kinase A activity (GO:0034199)3.62032070
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.61087062
54cerebellar Purkinje cell differentiation (GO:0021702)3.58109329
55long-term synaptic potentiation (GO:0060291)3.57802215
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55206380
57neuromuscular synaptic transmission (GO:0007274)3.54753099
58transmission of nerve impulse (GO:0019226)3.53768306
59synaptic vesicle endocytosis (GO:0048488)3.53601817
60establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.52250702
61mitochondrion transport along microtubule (GO:0047497)3.52250702
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52171043
63positive regulation of dendritic spine development (GO:0060999)3.52106307
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.51405094
65regulation of neurotransmitter secretion (GO:0046928)3.50612757
66prepulse inhibition (GO:0060134)3.49089119
67neuromuscular process controlling balance (GO:0050885)3.48746287
68regulation of synapse maturation (GO:0090128)3.48472024
69positive regulation of synapse maturation (GO:0090129)3.45074066
70regulation of dendritic spine morphogenesis (GO:0061001)3.44759492
71positive regulation of neurotransmitter transport (GO:0051590)3.43709392
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.42274499
73regulation of vesicle fusion (GO:0031338)3.40300563
74dendritic spine organization (GO:0097061)3.38774324
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38137608
76potassium ion homeostasis (GO:0055075)3.37614090
77glycine transport (GO:0015816)3.33692582
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33409858
79regulation of neurotransmitter transport (GO:0051588)3.32103857
80neuron recognition (GO:0008038)3.30096014
81synapse assembly (GO:0007416)3.29425109
82establishment of synaptic vesicle localization (GO:0097480)3.29191837
83synaptic vesicle transport (GO:0048489)3.29191837
84positive regulation of neurotransmitter secretion (GO:0001956)3.27986964
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26363723
86L-amino acid import (GO:0043092)3.26320899
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26075092
88mechanosensory behavior (GO:0007638)3.25429635
89membrane depolarization during action potential (GO:0086010)3.25424524
90axon ensheathment in central nervous system (GO:0032291)3.25214701
91central nervous system myelination (GO:0022010)3.25214701
92membrane depolarization (GO:0051899)3.22693398
93response to histamine (GO:0034776)3.22370582
94behavioral response to cocaine (GO:0048148)3.22101731
95amino acid import (GO:0043090)3.20486140
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.19863137
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19255681
98auditory behavior (GO:0031223)3.18995115
99behavioral fear response (GO:0001662)3.18378606
100behavioral defense response (GO:0002209)3.18378606
101membrane hyperpolarization (GO:0060081)3.17547825
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16948595
103response to auditory stimulus (GO:0010996)3.16773873
104vesicle transport along microtubule (GO:0047496)3.15991662
105neurofilament cytoskeleton organization (GO:0060052)3.15975376
106positive regulation of synapse assembly (GO:0051965)3.15220961
107neuronal ion channel clustering (GO:0045161)3.13603498
108dendrite morphogenesis (GO:0048813)3.13579292
109cellular sodium ion homeostasis (GO:0006883)3.13344412
110striatum development (GO:0021756)3.12329785
111positive regulation of synaptic transmission (GO:0050806)3.11878816
112mating behavior (GO:0007617)3.11426730
113G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11274587
114regulation of voltage-gated calcium channel activity (GO:1901385)3.09517302
115learning (GO:0007612)3.09341855
116cell communication by electrical coupling (GO:0010644)3.09318066
117synaptic transmission (GO:0007268)3.09301791
118acidic amino acid transport (GO:0015800)3.07691350
119potassium ion import (GO:0010107)3.07110693
120regulation of synaptic transmission (GO:0050804)3.06776316
121regulation of glutamate secretion (GO:0014048)3.04889369
122neuromuscular process (GO:0050905)3.02809715
123fear response (GO:0042596)2.99640574
124regulation of female receptivity (GO:0045924)2.97036168
125axonal fasciculation (GO:0007413)2.95826136
126social behavior (GO:0035176)2.95518963
127intraspecies interaction between organisms (GO:0051703)2.95518963
128adult walking behavior (GO:0007628)2.95467041
129long term synaptic depression (GO:0060292)2.94812561
130postsynaptic membrane organization (GO:0001941)2.94319404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.04061754
2GBX2_23144817_ChIP-Seq_PC3_Human3.47075203
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24445449
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17943394
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09098593
6REST_21632747_ChIP-Seq_MESCs_Mouse2.91128599
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.90523506
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80690762
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80690762
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72874166
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68248699
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61453676
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60881918
14DROSHA_22980978_ChIP-Seq_HELA_Human2.59246831
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55479947
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50693828
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.44351885
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.43061260
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28943513
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.25821578
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.24621174
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23686381
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.18289510
24* IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16348116
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10129864
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04071785
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96177578
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82389667
29AR_21572438_ChIP-Seq_LNCaP_Human1.76940659
30TAF15_26573619_Chip-Seq_HEK293_Human1.76403034
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72389891
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70453346
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.69806475
34SMAD4_21799915_ChIP-Seq_A2780_Human1.65323906
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64468321
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58546999
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56685179
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39992349
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.39654043
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38381267
41* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36473404
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33049229
43ZNF274_21170338_ChIP-Seq_K562_Hela1.32194708
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30957958
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30335112
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.29911536
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29618223
48P300_19829295_ChIP-Seq_ESCs_Human1.29463109
49* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29099431
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.28938209
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26972767
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24168002
53AR_25329375_ChIP-Seq_VCAP_Human1.21663779
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.21163129
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.20997731
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20992619
57* AR_19668381_ChIP-Seq_PC3_Human1.20078449
58STAT3_23295773_ChIP-Seq_U87_Human1.19242837
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17631420
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15382552
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14093926
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13862738
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12319647
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11826196
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09774077
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09702169
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08738186
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07569292
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07327946
70KDM2B_26808549_Chip-Seq_K562_Human1.06969727
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06394303
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05320055
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05167517
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.04347988
75* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04344418
76TCF4_23295773_ChIP-Seq_U87_Human1.04268795
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.03285898
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03212165
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.02972215
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02177820
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00974052
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00736433
83IGF1R_20145208_ChIP-Seq_DFB_Human0.99432990
84RNF2_27304074_Chip-Seq_NSC_Mouse0.98410238
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98081534
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97467616
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96946736
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96371260
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.95119266
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94437636
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.93907977
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.93728265
93RUNX2_22187159_ChIP-Seq_PCA_Human0.93669198
94AHR_22903824_ChIP-Seq_MCF-7_Human0.92853394
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92204023
96* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90766038
97SMAD3_21741376_ChIP-Seq_HESCs_Human0.89734228
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89463133
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.89264071
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88892269
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88307736
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88030598
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87271199
104TET1_21490601_ChIP-Seq_MESCs_Mouse0.86873222
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85559277
106TP53_16413492_ChIP-PET_HCT116_Human0.85341039
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.85203488
108SOX9_26525672_Chip-Seq_HEART_Mouse0.85013737
109CTCF_27219007_Chip-Seq_Bcells_Human0.84461867
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84348947
111JUN_21703547_ChIP-Seq_K562_Human0.83944238
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83897386
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83836915
114RXR_22108803_ChIP-Seq_LS180_Human0.83557073
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83493734
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83493734
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82073247
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81502722
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81302852
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.80274485
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77826502
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77238904
123OCT4_19829295_ChIP-Seq_ESCs_Human0.76281859
124REST_19997604_ChIP-ChIP_NEURONS_Mouse0.75477609
125POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.74282676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.53670710
2MP0003880_abnormal_central_pattern5.07012019
3MP0003635_abnormal_synaptic_transmissio4.27521291
4MP0004270_analgesia3.62298057
5MP0009745_abnormal_behavioral_response3.59634012
6MP0002822_catalepsy3.42145084
7MP0009046_muscle_twitch3.39999575
8MP0002064_seizures3.36075191
9* MP0002063_abnormal_learning/memory/cond3.33896083
10MP0001968_abnormal_touch/_nociception3.16899381
11MP0002572_abnormal_emotion/affect_behav2.86967579
12MP0002272_abnormal_nervous_system2.78715155
13MP0005423_abnormal_somatic_nervous2.71698258
14MP0002734_abnormal_mechanical_nocicepti2.63139860
15MP0001486_abnormal_startle_reflex2.59228195
16MP0002736_abnormal_nociception_after2.50420313
17MP0001501_abnormal_sleep_pattern2.50186181
18MP0002735_abnormal_chemical_nociception2.21523804
19MP0001440_abnormal_grooming_behavior2.19262703
20MP0002733_abnormal_thermal_nociception2.08179211
21MP0001970_abnormal_pain_threshold2.04367547
22MP0008569_lethality_at_weaning2.00776002
23* MP0002067_abnormal_sensory_capabilities1.98938523
24MP0002909_abnormal_adrenal_gland1.85751112
25MP0003329_amyloid_beta_deposits1.84935600
26MP0004924_abnormal_behavior1.79800548
27MP0005386_behavior/neurological_phenoty1.79800548
28MP0006276_abnormal_autonomic_nervous1.77043065
29MP0002184_abnormal_innervation1.74704070
30MP0009780_abnormal_chondrocyte_physiolo1.74119291
31MP0002557_abnormal_social/conspecific_i1.72153956
32MP0004858_abnormal_nervous_system1.71953987
33MP0005646_abnormal_pituitary_gland1.70560093
34* MP0004811_abnormal_neuron_physiology1.69257331
35MP0001529_abnormal_vocalization1.60349026
36MP0001984_abnormal_olfaction1.57932586
37MP0003121_genomic_imprinting1.57541812
38MP0003123_paternal_imprinting1.57359096
39MP0003879_abnormal_hair_cell1.53470310
40MP0000955_abnormal_spinal_cord1.51037857
41MP0003787_abnormal_imprinting1.50601345
42MP0000778_abnormal_nervous_system1.49033753
43MP0004142_abnormal_muscle_tone1.43231662
44* MP0002066_abnormal_motor_capabilities/c1.43179047
45MP0003633_abnormal_nervous_system1.37345627
46MP0003122_maternal_imprinting1.37297711
47* MP0002882_abnormal_neuron_morphology1.37053888
48MP0001905_abnormal_dopamine_level1.35860394
49MP0004885_abnormal_endolymph1.34811518
50MP0001502_abnormal_circadian_rhythm1.26910212
51MP0005645_abnormal_hypothalamus_physiol1.25998585
52MP0008872_abnormal_physiological_respon1.19097768
53MP0003631_nervous_system_phenotype1.15567443
54MP0008877_abnormal_DNA_methylation1.12999546
55MP0000013_abnormal_adipose_tissue1.07832185
56MP0002229_neurodegeneration1.06505785
57MP0005551_abnormal_eye_electrophysiolog1.06103659
58MP0000751_myopathy1.05940339
59MP0001188_hyperpigmentation1.03668825
60MP0008874_decreased_physiological_sensi1.01056850
61MP0004145_abnormal_muscle_electrophysio1.00173013
62* MP0002152_abnormal_brain_morphology0.99753541
63MP0002069_abnormal_eating/drinking_beha0.94179097
64MP0005535_abnormal_body_temperature0.92314255
65MP0002653_abnormal_ependyma_morphology0.90442737
66MP0003075_altered_response_to0.88973153
67MP0002837_dystrophic_cardiac_calcinosis0.87124546
68MP0003690_abnormal_glial_cell0.86964023
69MP0010386_abnormal_urinary_bladder0.86913423
70MP0001177_atelectasis0.85832588
71MP0003861_abnormal_nervous_system0.85502735
72MP0008961_abnormal_basal_metabolism0.85003347
73MP0000604_amyloidosis0.84186105
74MP0004085_abnormal_heartbeat0.83344710
75MP0003634_abnormal_glial_cell0.82779336
76MP0003283_abnormal_digestive_organ0.82448952
77MP0004742_abnormal_vestibular_system0.82142446
78MP0003632_abnormal_nervous_system0.81433882
79MP0000920_abnormal_myelination0.81163522
80MP0004147_increased_porphyrin_level0.78998336
81MP0002090_abnormal_vision0.77539441
82MP0001963_abnormal_hearing_physiology0.75634054
83MP0005167_abnormal_blood-brain_barrier0.73478486
84MP0000026_abnormal_inner_ear0.71087114
85MP0001986_abnormal_taste_sensitivity0.71046530
86* MP0002752_abnormal_somatic_nervous0.69331127
87MP0003938_abnormal_ear_development0.68366893
88MP0000569_abnormal_digit_pigmentation0.68210008
89MP0004215_abnormal_myocardial_fiber0.67939366
90MP0004484_altered_response_of0.66636370
91MP0004133_heterotaxia0.65076555
92MP0001664_abnormal_digestion0.64697570
93MP0002102_abnormal_ear_morphology0.63025038
94MP0010768_mortality/aging0.62283469
95MP0004043_abnormal_pH_regulation0.61950237
96MP0004233_abnormal_muscle_weight0.61902425
97MP0001348_abnormal_lacrimal_gland0.61886058
98MP0002638_abnormal_pupillary_reflex0.60495004
99MP0005623_abnormal_meninges_morphology0.59971820
100MP0005187_abnormal_penis_morphology0.59967826
101MP0000631_abnormal_neuroendocrine_gland0.59663085
102MP0005409_darkened_coat_color0.59540404
103MP0002876_abnormal_thyroid_physiology0.59094483
104MP0003137_abnormal_impulse_conducting0.59003643
105MP0005253_abnormal_eye_physiology0.58467873
106MP0001485_abnormal_pinna_reflex0.57671041
107MP0006292_abnormal_olfactory_placode0.56592190
108MP0000566_synostosis0.56152553
109MP0010234_abnormal_vibrissa_follicle0.54566595
110MP0001943_abnormal_respiration0.54292756
111MP0004510_myositis0.54130135
112MP0002081_perinatal_lethality0.53882567
113MP0010769_abnormal_survival0.50452394
114MP0003172_abnormal_lysosome_physiology0.50370780
115MP0002751_abnormal_autonomic_nervous0.50319711
116MP0003956_abnormal_body_size0.50088586
117* MP0005394_taste/olfaction_phenotype0.49815226
118* MP0005499_abnormal_olfactory_system0.49815226
119MP0006072_abnormal_retinal_apoptosis0.49410762
120MP0002082_postnatal_lethality0.48347221
121MP0010770_preweaning_lethality0.48347221
122MP0001299_abnormal_eye_distance/0.47816788

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.12202996
2Myokymia (HP:0002411)7.38337228
3Focal seizures (HP:0007359)6.02591026
4Visual hallucinations (HP:0002367)5.57203644
5Atonic seizures (HP:0010819)5.05849719
6Epileptic encephalopathy (HP:0200134)4.86573935
7Febrile seizures (HP:0002373)4.80704517
8Progressive cerebellar ataxia (HP:0002073)4.52770085
9Absence seizures (HP:0002121)4.46937987
10Action tremor (HP:0002345)4.24137017
11Generalized tonic-clonic seizures (HP:0002069)4.09028666
12Dialeptic seizures (HP:0011146)4.07084395
13Supranuclear gaze palsy (HP:0000605)3.73666129
14Gaze-evoked nystagmus (HP:0000640)3.48616197
15Impaired vibration sensation in the lower limbs (HP:0002166)3.46102077
16Depression (HP:0000716)3.45778631
17Ankle clonus (HP:0011448)3.43750572
18Broad-based gait (HP:0002136)3.42964056
19Dysdiadochokinesis (HP:0002075)3.42313714
20Poor eye contact (HP:0000817)3.35864495
21Anxiety (HP:0000739)3.30534630
22Dysmetria (HP:0001310)3.25960963
23Truncal ataxia (HP:0002078)3.22642273
24Abnormal eating behavior (HP:0100738)3.10410451
25Impaired social interactions (HP:0000735)3.09569013
26Abnormal social behavior (HP:0012433)3.09569013
27Postural instability (HP:0002172)3.08986953
28Urinary bladder sphincter dysfunction (HP:0002839)3.05128266
29Hyperventilation (HP:0002883)3.02413945
30Amblyopia (HP:0000646)2.99819764
31Cerebral hypomyelination (HP:0006808)2.93141009
32Scanning speech (HP:0002168)2.87508908
33Abnormality of the lower motor neuron (HP:0002366)2.86618717
34Impaired smooth pursuit (HP:0007772)2.82461012
35Mutism (HP:0002300)2.80738562
36Peripheral hypomyelination (HP:0007182)2.79572834
37Sleep apnea (HP:0010535)2.74026649
38Torticollis (HP:0000473)2.73844473
39Progressive inability to walk (HP:0002505)2.70781670
40Urinary urgency (HP:0000012)2.70531869
41Papilledema (HP:0001085)2.68840263
42Pheochromocytoma (HP:0002666)2.65762843
43Bradykinesia (HP:0002067)2.62542453
44Genetic anticipation (HP:0003743)2.60904944
45Dysmetric saccades (HP:0000641)2.59884586
46Ventricular fibrillation (HP:0001663)2.59108060
47Focal dystonia (HP:0004373)2.58040047
48Hemiparesis (HP:0001269)2.57964940
49Spastic gait (HP:0002064)2.57358613
50Hemiplegia (HP:0002301)2.56253269
51Annular pancreas (HP:0001734)2.55588481
52Intention tremor (HP:0002080)2.54385766
53Abnormality of binocular vision (HP:0011514)2.52573628
54Diplopia (HP:0000651)2.52573628
55Morphological abnormality of the pyramidal tract (HP:0002062)2.52190239
56Status epilepticus (HP:0002133)2.51609624
57Abnormality of ocular smooth pursuit (HP:0000617)2.47905479
58Amyotrophic lateral sclerosis (HP:0007354)2.47619969
59Akinesia (HP:0002304)2.47468172
60Spastic tetraplegia (HP:0002510)2.46795023
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.44012743
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.44012743
63Gait imbalance (HP:0002141)2.40897875
64Cerebral inclusion bodies (HP:0100314)2.39933086
65Drooling (HP:0002307)2.39055488
66Excessive salivation (HP:0003781)2.39055488
67Limb dystonia (HP:0002451)2.38677761
68Stereotypic behavior (HP:0000733)2.36837377
69Epileptiform EEG discharges (HP:0011182)2.35944494
70Insidious onset (HP:0003587)2.34636866
71Termporal pattern (HP:0011008)2.34636866
72Neurofibrillary tangles (HP:0002185)2.34498247
73Cholecystitis (HP:0001082)2.34165794
74Abnormal gallbladder physiology (HP:0012438)2.34165794
75Impaired vibratory sensation (HP:0002495)2.32410808
76Craniofacial dystonia (HP:0012179)2.30884904
77Neuroendocrine neoplasm (HP:0100634)2.30878380
78Resting tremor (HP:0002322)2.30850849
79EEG with generalized epileptiform discharges (HP:0011198)2.24311671
80CNS hypomyelination (HP:0003429)2.18363180
81Lower limb muscle weakness (HP:0007340)2.15608782
82Aplasia/Hypoplasia of the brainstem (HP:0007362)2.15140753
83Hypoplasia of the brainstem (HP:0002365)2.15140753
84Fetal akinesia sequence (HP:0001989)2.14514800
85Generalized myoclonic seizures (HP:0002123)2.12666996
86Absent speech (HP:0001344)2.12318035
87Hypsarrhythmia (HP:0002521)2.12283443
88Cortical dysplasia (HP:0002539)2.11655538
89Abnormality of the corticospinal tract (HP:0002492)2.10210716
90Gait ataxia (HP:0002066)2.07791379
91Hand muscle atrophy (HP:0009130)2.07626906
92Megalencephaly (HP:0001355)2.06162506
93Neuronal loss in central nervous system (HP:0002529)2.06008641
94Inability to walk (HP:0002540)2.06007526
95Incomplete penetrance (HP:0003829)2.05385580
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05362128
97Hypoplasia of the corpus callosum (HP:0002079)2.03012809
98Pointed chin (HP:0000307)2.02224818
99Delusions (HP:0000746)2.01806383
100Poor suck (HP:0002033)2.01046785
101Failure to thrive in infancy (HP:0001531)2.00981529
102Abnormality of saccadic eye movements (HP:0000570)2.00241253
103Polyphagia (HP:0002591)2.00098591
104Psychosis (HP:0000709)1.98637366
105Apathy (HP:0000741)1.95826836
106Spastic tetraparesis (HP:0001285)1.95148990
107Agitation (HP:0000713)1.93367276
108Paraplegia (HP:0010550)1.92598383
109Rigidity (HP:0002063)1.92121931
110Clonus (HP:0002169)1.90815268
111Retinal dysplasia (HP:0007973)1.90362581
112Obstructive sleep apnea (HP:0002870)1.87812091
113Bundle branch block (HP:0011710)1.87454151
114Lissencephaly (HP:0001339)1.87054483
115Hammertoe (HP:0001765)1.86749559
116Insomnia (HP:0100785)1.86553235
117Abnormal EKG (HP:0003115)1.84795010
118Rapidly progressive (HP:0003678)1.84704718
119Muscular hypotonia of the trunk (HP:0008936)1.84532878
120Choreoathetosis (HP:0001266)1.83570492
121Neoplasm of the peripheral nervous system (HP:0100007)1.83340440
122Hypoventilation (HP:0002791)1.82774991
123Split foot (HP:0001839)1.82141879
124Postural tremor (HP:0002174)1.80847083
125Blue irides (HP:0000635)1.80280542
126Specific learning disability (HP:0001328)1.77795503
127Tetraplegia (HP:0002445)1.76635814
128Lower limb asymmetry (HP:0100559)1.75924076
129Lower limb amyotrophy (HP:0007210)1.75706728
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73844962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.58689063
2EPHA44.57987544
3MAP3K93.95894978
4MAP3K43.09553657
5MINK12.75001508
6MAP2K72.56965198
7MAP3K122.46504195
8DAPK22.43445702
9RIPK42.36116690
10KSR22.31019140
11PAK62.19952496
12MAP2K42.08582586
13MARK12.06413596
14NTRK11.94683771
15PRKD31.90575409
16CAMKK11.89492260
17NTRK21.87187910
18ARAF1.83068303
19BCR1.66323528
20GRK51.63912503
21CDK191.63807032
22DAPK11.58882162
23CDK51.54770897
24KSR11.53595311
25CASK1.53563681
26MAP3K131.50088434
27PLK21.48756773
28STK381.47318632
29PNCK1.43312729
30DYRK21.40360262
31FES1.36603220
32CAMKK21.29848202
33TNIK1.29119636
34PRKCG1.25194804
35PRPF4B1.23410782
36MAP3K21.16464245
37SIK21.15236697
38UHMK11.08116116
39TYRO31.07354032
40TRIM281.03669640
41PINK11.02480343
42CAMK2A0.98696096
43MAP4K20.97796648
44SGK2230.97086609
45SGK4940.97086609
46MAPK130.96799013
47LIMK10.95302009
48CDK180.93663862
49CDK150.91534270
50RAF10.91166165
51CAMK10.90738040
52TAOK10.89716754
53CDK140.89024995
54PRKCH0.88328564
55BMPR20.87487293
56PTK2B0.85673801
57OXSR10.85156228
58LMTK20.84732049
59STK110.83964656
60LATS20.83734979
61CSNK1G30.83002114
62RET0.82807131
63CAMK2B0.82760045
64TNK20.82096210
65SGK20.80011830
66CDK11A0.79665009
67CSNK1A1L0.77067012
68PKN10.74405785
69MAP3K10.72197745
70WNK10.71952737
71SGK30.70734449
72PHKG10.70696372
73PHKG20.70696372
74PDK10.68343597
75ALK0.68253427
76TESK10.68151110
77EPHA30.68058967
78NEK10.67908914
79SGK10.65968901
80PDPK10.64533439
81PAK30.64355964
82WNK30.62219588
83FGFR20.59434863
84DYRK1A0.58790042
85DYRK1B0.57807469
86NME10.56281428
87CAMK2G0.54579720
88MARK20.53895257
89CAMK2D0.52999575
90CSNK1G10.51969684
91CSNK1G20.48950622
92RPS6KA30.48275515
93PRKCE0.47874871
94FER0.47665140
95BRAF0.47330146
96SCYL20.47030094
97CDC42BPA0.45830972
98MAP2K10.45650792
99MAPK100.45262832
100NEK60.44014353
101PRKCZ0.43999301
102CAMK40.43077584
103DAPK30.42828705
104MAPK120.41490434
105FYN0.40889691
106AKT30.40776975
107BRSK10.40693999
108CAMK1G0.38529733
109CSNK1E0.37971799
110FGR0.37930824
111MAPKAPK50.37544252
112RIPK10.37044014
113ROCK20.36324514
114MAP3K70.36310668
115SIK30.35707808
116MOS0.35256480
117PRKACA0.34382983
118WNK40.32982712
119CSNK1D0.32590098
120PRKAA10.30601287
121BCKDK0.28766293
122CSNK1A10.28312173
123MAP3K110.28307780
124PRKG10.27550308
125MAPK80.27207312

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77042978
2Synaptic vesicle cycle_Homo sapiens_hsa047213.59468317
3Olfactory transduction_Homo sapiens_hsa047402.86974322
4GABAergic synapse_Homo sapiens_hsa047272.77936108
5Long-term potentiation_Homo sapiens_hsa047202.70131839
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67155387
7Circadian entrainment_Homo sapiens_hsa047132.66796878
8Morphine addiction_Homo sapiens_hsa050322.53779073
9Glutamatergic synapse_Homo sapiens_hsa047242.53577518
10Amphetamine addiction_Homo sapiens_hsa050312.52195495
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32813167
12Dopaminergic synapse_Homo sapiens_hsa047282.19571123
13Salivary secretion_Homo sapiens_hsa049702.19476560
14Insulin secretion_Homo sapiens_hsa049111.97263981
15Gastric acid secretion_Homo sapiens_hsa049711.90515882
16Cholinergic synapse_Homo sapiens_hsa047251.86951154
17Taste transduction_Homo sapiens_hsa047421.82767676
18Collecting duct acid secretion_Homo sapiens_hsa049661.77962665
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77886124
20Long-term depression_Homo sapiens_hsa047301.73326818
21Cocaine addiction_Homo sapiens_hsa050301.71446516
22Renin secretion_Homo sapiens_hsa049241.71273316
23Serotonergic synapse_Homo sapiens_hsa047261.64303854
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64050731
25Oxytocin signaling pathway_Homo sapiens_hsa049211.62515921
26Calcium signaling pathway_Homo sapiens_hsa040201.60574633
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55546294
28GnRH signaling pathway_Homo sapiens_hsa049121.43136816
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35586268
30Gap junction_Homo sapiens_hsa045401.33382225
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33276981
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32423424
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28542558
34cAMP signaling pathway_Homo sapiens_hsa040241.24786380
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19762979
36Phototransduction_Homo sapiens_hsa047441.14840678
37Vibrio cholerae infection_Homo sapiens_hsa051101.09452791
38Type II diabetes mellitus_Homo sapiens_hsa049301.09318772
39Cardiac muscle contraction_Homo sapiens_hsa042601.09094086
40Estrogen signaling pathway_Homo sapiens_hsa049151.08779971
41Glioma_Homo sapiens_hsa052141.04860554
42Nitrogen metabolism_Homo sapiens_hsa009101.04099073
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01928363
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98658827
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97561657
46Melanogenesis_Homo sapiens_hsa049160.95293739
47ErbB signaling pathway_Homo sapiens_hsa040120.91343322
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.91137318
49Oocyte meiosis_Homo sapiens_hsa041140.87183814
50Vitamin B6 metabolism_Homo sapiens_hsa007500.86632788
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84933519
52Pancreatic secretion_Homo sapiens_hsa049720.84714556
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83387943
54Axon guidance_Homo sapiens_hsa043600.83088972
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81835511
56Thyroid hormone synthesis_Homo sapiens_hsa049180.79503739
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.79100737
58Dorso-ventral axis formation_Homo sapiens_hsa043200.78359261
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66464378
60Dilated cardiomyopathy_Homo sapiens_hsa054140.65576068
61MAPK signaling pathway_Homo sapiens_hsa040100.65180245
62Choline metabolism in cancer_Homo sapiens_hsa052310.64813590
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64321631
64Type I diabetes mellitus_Homo sapiens_hsa049400.61700665
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59373607
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58745902
67VEGF signaling pathway_Homo sapiens_hsa043700.58209512
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58157151
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.57765266
70Glucagon signaling pathway_Homo sapiens_hsa049220.57479540
71Alzheimers disease_Homo sapiens_hsa050100.56293243
72Inositol phosphate metabolism_Homo sapiens_hsa005620.55468355
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53742408
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53143107
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52954744
76Ras signaling pathway_Homo sapiens_hsa040140.50594225
77Bile secretion_Homo sapiens_hsa049760.50189889
78Alcoholism_Homo sapiens_hsa050340.50167417
79Rap1 signaling pathway_Homo sapiens_hsa040150.49672258
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48701163
81Arginine and proline metabolism_Homo sapiens_hsa003300.48588427
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.47216664
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46530505
84Endocytosis_Homo sapiens_hsa041440.46184901
85Oxidative phosphorylation_Homo sapiens_hsa001900.45820086
86mTOR signaling pathway_Homo sapiens_hsa041500.44611306
87Regulation of autophagy_Homo sapiens_hsa041400.42263398
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41557244
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40721429
90Circadian rhythm_Homo sapiens_hsa047100.40380402
91Non-small cell lung cancer_Homo sapiens_hsa052230.40089443
92Prion diseases_Homo sapiens_hsa050200.39672591
93Hippo signaling pathway_Homo sapiens_hsa043900.38783502
94AMPK signaling pathway_Homo sapiens_hsa041520.38322100
95Parkinsons disease_Homo sapiens_hsa050120.38320719
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37918425
97African trypanosomiasis_Homo sapiens_hsa051430.36558328
98Insulin signaling pathway_Homo sapiens_hsa049100.35396290
99Butanoate metabolism_Homo sapiens_hsa006500.35358543
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34171586
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32405482
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32167992
103Steroid biosynthesis_Homo sapiens_hsa001000.31470236
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31222468
105Chemokine signaling pathway_Homo sapiens_hsa040620.30217514
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29417782
107Renal cell carcinoma_Homo sapiens_hsa052110.28563364
108Ovarian steroidogenesis_Homo sapiens_hsa049130.28447442
109Endometrial cancer_Homo sapiens_hsa052130.27317499
110Wnt signaling pathway_Homo sapiens_hsa043100.27289826
111Rheumatoid arthritis_Homo sapiens_hsa053230.27016978
112Tight junction_Homo sapiens_hsa045300.26414407
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.26397044
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.26106254
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24614740
116Arginine biosynthesis_Homo sapiens_hsa002200.23476545
117Huntingtons disease_Homo sapiens_hsa050160.21957579
118Ether lipid metabolism_Homo sapiens_hsa005650.21742376

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