ENO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.08237169
2regulation of skeletal muscle contraction (GO:0014819)8.65085644
3actin-mediated cell contraction (GO:0070252)8.61843164
4myofibril assembly (GO:0030239)7.92061742
5cardiac myofibril assembly (GO:0055003)7.77468525
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.65038018
7sarcoplasmic reticulum calcium ion transport (GO:0070296)7.12740645
8plasma membrane repair (GO:0001778)6.93475305
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.87141818
10negative regulation of potassium ion transmembrane transport (GO:1901380)6.62544821
11skeletal muscle contraction (GO:0003009)6.52136894
12cardiac muscle contraction (GO:0060048)6.50971579
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.49591090
14actin filament-based movement (GO:0030048)6.44152957
15striated muscle contraction (GO:0006941)6.39993430
16tricarboxylic acid cycle (GO:0006099)6.03779003
17regulation of relaxation of muscle (GO:1901077)6.02017328
18actomyosin structure organization (GO:0031032)6.00634049
19cardiac muscle cell development (GO:0055013)5.93637736
20myotube cell development (GO:0014904)5.88293454
21cardiac cell development (GO:0055006)5.57752060
22carnitine shuttle (GO:0006853)5.43485184
23regulation of actin filament-based movement (GO:1903115)5.40256777
24regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.40092202
25regulation of cell communication by electrical coupling (GO:0010649)5.39793932
26regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.38217291
27regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.26877621
28response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.23713023
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.21926942
30cardiac muscle tissue morphogenesis (GO:0055008)5.21232614
31skeletal muscle adaptation (GO:0043501)5.19676557
32heart contraction (GO:0060047)5.18479493
33heart process (GO:0003015)5.18479493
34cardiac muscle hypertrophy (GO:0003300)4.89868657
35skeletal muscle tissue development (GO:0007519)4.89858610
36regulation of sarcomere organization (GO:0060297)4.88205192
37regulation of acyl-CoA biosynthetic process (GO:0050812)4.86582335
38muscle tissue morphogenesis (GO:0060415)4.84110389
39striated muscle hypertrophy (GO:0014897)4.78011663
40regulation of striated muscle contraction (GO:0006942)4.76352659
41ventricular cardiac muscle cell action potential (GO:0086005)4.73716440
42adult heart development (GO:0007512)4.67262940
43fatty acid transmembrane transport (GO:1902001)4.63284152
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.58317414
45creatine metabolic process (GO:0006600)4.58181842
46glucan biosynthetic process (GO:0009250)4.57278881
47muscle contraction (GO:0006936)4.56505420
48muscle cell cellular homeostasis (GO:0046716)4.52411652
49regulation of cofactor metabolic process (GO:0051193)4.48863510
50regulation of coenzyme metabolic process (GO:0051196)4.48863510
51heart trabecula formation (GO:0060347)4.47329122
52ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.46055686
53response to inactivity (GO:0014854)4.41187841
54muscle cell fate commitment (GO:0042693)4.32991181
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.31898310
56bundle of His cell to Purkinje myocyte communication (GO:0086069)4.27045302
57positive regulation of myotube differentiation (GO:0010831)4.27001654
58regulation of membrane repolarization (GO:0060306)4.22729611
59muscle hypertrophy (GO:0014896)4.22081097
60muscle atrophy (GO:0014889)4.19948413
61muscle system process (GO:0003012)4.18070489
62pyrimidine ribonucleoside catabolic process (GO:0046133)4.13813977
63cytidine deamination (GO:0009972)4.12712396
64cytidine metabolic process (GO:0046087)4.12712396
65cytidine catabolic process (GO:0006216)4.12712396
66striated muscle cell development (GO:0055002)4.12678970
67striated muscle adaptation (GO:0014888)4.11596419
68muscle organ development (GO:0007517)4.08493216
69muscle structure development (GO:0061061)4.07031743
70oxidative phosphorylation (GO:0006119)4.05651276
71ATP synthesis coupled proton transport (GO:0015986)4.01356016
72energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01356016
73carnitine transmembrane transport (GO:1902603)3.98241450
74response to muscle activity (GO:0014850)3.94540788
75polysaccharide catabolic process (GO:0000272)3.91227830
76glycogen catabolic process (GO:0005980)3.91030982
77striated muscle atrophy (GO:0014891)3.85280118
78muscle fiber development (GO:0048747)3.81191197
79myoblast fusion (GO:0007520)3.80809319
80regulation of the force of heart contraction (GO:0002026)3.78803137
81respiratory electron transport chain (GO:0022904)3.76552412
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74943637
83response to activity (GO:0014823)3.71287630
84regulation of ATPase activity (GO:0043462)3.70378600
85regulation of ATP catabolic process (GO:1903289)3.70378600
86negative regulation of protein localization to cell surface (GO:2000009)3.69755716
87electron transport chain (GO:0022900)3.65199939
88glucan catabolic process (GO:0009251)3.63910925
89glycogen metabolic process (GO:0005977)3.63907390
90amino-acid betaine transport (GO:0015838)3.60666911
91carnitine transport (GO:0015879)3.60666911
92regulation of sulfur metabolic process (GO:0042762)3.58307688
93NADH metabolic process (GO:0006734)3.58306848
94cardiac muscle hypertrophy in response to stress (GO:0014898)3.57282004
95muscle hypertrophy in response to stress (GO:0003299)3.57282004
96cardiac muscle adaptation (GO:0014887)3.57282004
97cellular glucan metabolic process (GO:0006073)3.56276927
98glucan metabolic process (GO:0044042)3.56276927
99positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.55681087
100positive regulation of myoblast differentiation (GO:0045663)3.55104952
101muscle cell development (GO:0055001)3.54703113
102negative regulation of calcium ion transmembrane transport (GO:1903170)3.54381451
103negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.54381451
104negative regulation of potassium ion transport (GO:0043267)3.52051632
105skeletal muscle fiber development (GO:0048741)3.50299886
106negative regulation of muscle hypertrophy (GO:0014741)3.49656888
107regulation of myoblast differentiation (GO:0045661)3.49569254
108regulation of muscle system process (GO:0090257)3.47292362
109fructose metabolic process (GO:0006000)3.47286507
110striated muscle tissue development (GO:0014706)3.46377891
111cardiac muscle cell action potential involved in contraction (GO:0086002)3.45763191
112cardiac muscle cell action potential (GO:0086001)3.42873284
113regulation of calcium ion transmembrane transport (GO:1903169)3.42568424
114regulation of calcium ion transmembrane transporter activity (GO:1901019)3.42568424
115regulation of muscle contraction (GO:0006937)3.41470261
116muscle adaptation (GO:0043500)3.41100015
117cell communication involved in cardiac conduction (GO:0086065)3.39693632
118cellular polysaccharide catabolic process (GO:0044247)3.39401959
1192-oxoglutarate metabolic process (GO:0006103)3.37793937
120glycogen biosynthetic process (GO:0005978)3.36657866
121negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.34471105
122syncytium formation by plasma membrane fusion (GO:0000768)3.32198327
123regulation of skeletal muscle cell differentiation (GO:2001014)3.31913928
124positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.30319432
125muscle organ morphogenesis (GO:0048644)3.28043317
126regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.27165016
127myotube differentiation (GO:0014902)3.25549871
128actin-myosin filament sliding (GO:0033275)10.4237228
129muscle filament sliding (GO:0030049)10.4237228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.46137395
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.98101393
3EZH2_22144423_ChIP-Seq_EOC_Human4.98002429
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.54950000
5EP300_21415370_ChIP-Seq_HL-1_Mouse4.39058845
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.35350468
7TBX20_22080862_ChIP-Seq_HEART_Mouse4.11105909
8TBX20_22328084_ChIP-Seq_HEART_Mouse4.11105909
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.85403831
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.68420435
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.31270053
12RARG_19884340_ChIP-ChIP_MEFs_Mouse3.23847974
13ZNF263_19887448_ChIP-Seq_K562_Human3.13021220
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.08301342
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04233749
16GATA4_21415370_ChIP-Seq_HL-1_Mouse2.52627252
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.11948689
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01123078
19* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.99938600
20BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.97806857
21CLOCK_20551151_ChIP-Seq_293T_Human1.93991969
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93587898
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90825470
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86062438
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79229224
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78519207
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71830121
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.57874195
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.53027554
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52143458
31CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.51606491
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49259907
33NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47591050
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46657215
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43392704
36* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42306884
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42209682
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40026066
39IGF1R_20145208_ChIP-Seq_DFB_Human1.36308912
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.35769433
41CTCF_27219007_Chip-Seq_Bcells_Human1.34222005
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31088950
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30642019
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.29296849
45GATA1_22025678_ChIP-Seq_K562_Human1.25048021
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24739889
47ATF3_27146783_Chip-Seq_COLON_Human1.24530240
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24237833
49DROSHA_22980978_ChIP-Seq_HELA_Human1.24223199
50* KDM2B_26808549_Chip-Seq_DND41_Human1.23949374
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.22642535
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.22458285
53RACK7_27058665_Chip-Seq_MCF-7_Human1.21739025
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20316486
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20021169
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.17461212
57ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16722040
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16605140
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16071045
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15406915
61TP63_22573176_ChIP-Seq_HFKS_Human1.15305735
62SMC3_22415368_ChIP-Seq_MEFs_Mouse1.13788237
63CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13252535
64SPI1_20517297_ChIP-Seq_HL60_Human1.11608893
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10386859
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10246149
67SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09002187
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08966446
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.08064842
70ZNF274_21170338_ChIP-Seq_K562_Hela1.06139886
71MYC_27129775_Chip-Seq_CORNEA_Mouse1.06041825
72CTCF_21964334_Chip-Seq_Bcells_Human1.05604405
73CJUN_26792858_Chip-Seq_BT549_Human1.05014542
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04145257
75STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03968345
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03321288
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.02960354
78FOXH1_21741376_ChIP-Seq_ESCs_Human1.02919792
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02470400
80LXR_22292898_ChIP-Seq_THP-1_Human1.02371376
81YY1_22570637_ChIP-Seq_MALME-3M_Human1.02151981
82P68_20966046_ChIP-Seq_HELA_Human1.01963137
83OCT4_20526341_ChIP-Seq_ESCs_Human1.01879059
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01755156
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.01151061
86RARB_27405468_Chip-Seq_BRAIN_Mouse1.01015856
87SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00680706
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00009778
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.98408903
90RUNX1_27514584_Chip-Seq_MCF-7_Human0.96216513
91BCL6_27268052_Chip-Seq_Bcells_Human0.94722015
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94695520
93CBX2_27304074_Chip-Seq_ESCs_Mouse0.94601920
94HTT_18923047_ChIP-ChIP_STHdh_Human0.93251625
95AR_21572438_ChIP-Seq_LNCaP_Human0.93163184
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92063992
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91937682
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90609269
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90331679
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.89459533
101VDR_22108803_ChIP-Seq_LS180_Human0.89287818
102RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89275515
103SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87673404
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86704813
105E2F1_20622854_ChIP-Seq_HELA_Human0.86501082
106LXR_22158963_ChIP-Seq_LIVER_Mouse0.85431011
107GATA1_19941826_ChIP-Seq_K562_Human0.84112419
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.83912596
109BCOR_27268052_Chip-Seq_Bcells_Human0.83867958
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82073004
111GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81600036
112AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81188862
113SA1_27219007_Chip-Seq_Bcells_Human0.80388564
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.79608022
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79570463
116CTCF_26484167_Chip-Seq_Bcells_Mouse0.79353115
117TDRD3_21172665_ChIP-Seq_MCF-7_Human0.78744789
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78431807
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78155113
120CSB_26484114_Chip-Seq_FIBROBLAST_Human0.78084907
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77123800
122TCF7_22412390_ChIP-Seq_EML_Mouse0.76233001
123CREB1_26743006_Chip-Seq_LNCaP_Human0.76160220
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.75376690
125NANOG_20526341_ChIP-Seq_ESCs_Human0.74899855
126GATA6_21074721_ChIP-Seq_CACO-2_Human0.74489365
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.74134799
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.73834176
129STAT1_20625510_ChIP-Seq_HELA_Human0.73440171
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.72766899
131CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.72659625
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.72652576
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72627519
134PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.71959319
135GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71793721
136P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.71703055
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71441581
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71431309
139RAC3_21632823_ChIP-Seq_H3396_Human0.71410988
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.71312359
141GATA2_19941826_ChIP-Seq_K562_Human0.70301673
142DNAJC2_21179169_ChIP-ChIP_NT2_Human0.70237760
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70058911
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.69916113
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69693066
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69693066
147UBF1/2_26484160_Chip-Seq_HMECs_Human0.69496845
148P53_22127205_ChIP-Seq_FIBROBLAST_Human0.69101793
149EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68968871
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.68170141
151MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67648379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.78584194
2MP0002837_dystrophic_cardiac_calcinosis5.72916054
3MP0000751_myopathy5.52532160
4MP0000749_muscle_degeneration5.35903468
5MP0004084_abnormal_cardiac_muscle4.87788642
6MP0004036_abnormal_muscle_relaxation4.49154127
7MP0004145_abnormal_muscle_electrophysio4.37559092
8MP0004215_abnormal_myocardial_fiber3.75438226
9MP0005330_cardiomyopathy3.50844433
10MP0004087_abnormal_muscle_fiber3.48041542
11MP0002106_abnormal_muscle_physiology3.33646051
12MP0000750_abnormal_muscle_regeneration3.18051432
13MP0005620_abnormal_muscle_contractility3.05996109
14MP0000747_muscle_weakness3.03334041
15MP0002269_muscular_atrophy2.92304737
16MP0000759_abnormal_skeletal_muscle2.78742440
17MP0002972_abnormal_cardiac_muscle2.78217644
18MP0005369_muscle_phenotype2.72808779
19MP0004130_abnormal_muscle_cell2.69058336
20MP0010630_abnormal_cardiac_muscle2.36445636
21MP0008775_abnormal_heart_ventricle2.32418229
22MP0003137_abnormal_impulse_conducting2.25673569
23MP0001544_abnormal_cardiovascular_syste2.19149996
24MP0005385_cardiovascular_system_phenoty2.19149996
25MP0004484_altered_response_of2.18853787
26MP0004233_abnormal_muscle_weight2.10090290
27MP0006036_abnormal_mitochondrial_physio1.88539067
28MP0006138_congestive_heart_failure1.87144825
29MP0003221_abnormal_cardiomyocyte_apopto1.85113490
30MP0002332_abnormal_exercise_endurance1.77930739
31MP0003828_pulmonary_edema1.74248534
32MP0003950_abnormal_plasma_membrane1.70766082
33MP0004510_myositis1.65360941
34MP0004085_abnormal_heartbeat1.56871096
35MP0004270_analgesia1.50465445
36MP0000733_abnormal_muscle_development1.44141722
37MP0002127_abnormal_cardiovascular_syste1.42868846
38MP0005666_abnormal_adipose_tissue1.33928950
39MP0002108_abnormal_muscle_morphology1.33331456
40MP0004185_abnormal_adipocyte_glucose1.17536609
41MP0003567_abnormal_fetal_cardiomyocyte1.13071612
42MP0002234_abnormal_pharynx_morphology1.09281249
43MP0006035_abnormal_mitochondrial_morpho1.06867947
44MP0001661_extended_life_span1.05228685
45MP0000266_abnormal_heart_morphology1.05223266
46MP0005275_abnormal_skin_tensile1.02006260
47MP0003705_abnormal_hypodermis_morpholog1.02001409
48MP0000343_altered_response_to0.98703977
49MP0005266_abnormal_metabolism0.94831094
50MP0003806_abnormal_nucleotide_metabolis0.90849016
51MP0005375_adipose_tissue_phenotype0.90802832
52MP0005670_abnormal_white_adipose0.87648447
53MP0002822_catalepsy0.87390329
54MP0002971_abnormal_brown_adipose0.81452267
55MP0003279_aneurysm0.80868564
56MP0000372_irregular_coat_pigmentation0.73280559
57MP0005165_increased_susceptibility_to0.72201584
58MP0003566_abnormal_cell_adhesion0.70287749
59MP0002128_abnormal_blood_circulation0.66883140
60MP0008438_abnormal_cutaneous_collagen0.66142417
61MP0010368_abnormal_lymphatic_system0.65917879
62MP0005451_abnormal_body_composition0.61931854
63MP0000230_abnormal_systemic_arterial0.61503676
64MP0000013_abnormal_adipose_tissue0.58314063
65MP0010030_abnormal_orbit_morphology0.57085199
66MP0004134_abnormal_chest_morphology0.54260660
67MP0009780_abnormal_chondrocyte_physiolo0.52272937
68MP0001879_abnormal_lymphatic_vessel0.49856383
69MP0000767_abnormal_smooth_muscle0.49696892
70MP0004043_abnormal_pH_regulation0.49491191
71MP0000003_abnormal_adipose_tissue0.49289945
72MP0004272_abnormal_basement_membrane0.46147559
73MP0005623_abnormal_meninges_morphology0.45872993
74MP0003879_abnormal_hair_cell0.45124233
75MP0004147_increased_porphyrin_level0.44328494
76MP0002078_abnormal_glucose_homeostasis0.42076733
77MP0002925_abnormal_cardiovascular_devel0.42057379
78MP0008961_abnormal_basal_metabolism0.41778134
79MP0005503_abnormal_tendon_morphology0.41735700
80MP0005319_abnormal_enzyme/_coenzyme0.39925717
81MP0000762_abnormal_tongue_morphology0.37249888
82MP0004142_abnormal_muscle_tone0.36935290
83MP0008569_lethality_at_weaning0.35759547
84MP0001784_abnormal_fluid_regulation0.34482270
85MP0003948_abnormal_gas_homeostasis0.32941815
86MP0002114_abnormal_axial_skeleton0.32789660
87MP0001614_abnormal_blood_vessel0.32133587
88MP0003984_embryonic_growth_retardation0.31965747
89MP0002877_abnormal_melanocyte_morpholog0.31548549
90MP0002088_abnormal_embryonic_growth/wei0.31242155
91MP0005083_abnormal_biliary_tract0.31026546
92MP0009384_cardiac_valve_regurgitation0.30446074
93MP0002638_abnormal_pupillary_reflex0.29883572
94MP0005334_abnormal_fat_pad0.29307190
95MP0005166_decreased_susceptibility_to0.28986730
96MP0001299_abnormal_eye_distance/0.28983658
97MP0005332_abnormal_amino_acid0.28676493
98MP0005167_abnormal_blood-brain_barrier0.28240595
99MP0001346_abnormal_lacrimal_gland0.27252726
100MP0002734_abnormal_mechanical_nocicepti0.25586621
101MP0006276_abnormal_autonomic_nervous0.25022083
102MP0005187_abnormal_penis_morphology0.24846145
103MP0000579_abnormal_nail_morphology0.24371220
104MP0005452_abnormal_adipose_tissue0.23331706
105MP0002909_abnormal_adrenal_gland0.22914635
106MP0005423_abnormal_somatic_nervous0.22838892
107MP0001943_abnormal_respiration0.22755836
108MP0003941_abnormal_skin_development0.22748008
109MP0009250_abnormal_appendicular_skeleto0.21596615
110MP0009115_abnormal_fat_cell0.21553818
111MP0002249_abnormal_larynx_morphology0.21552179
112MP0005584_abnormal_enzyme/coenzyme_acti0.19879060
113MP0002896_abnormal_bone_mineralization0.19148385
114MP0003045_fibrosis0.18895504
115MP0003656_abnormal_erythrocyte_physiolo0.18466641
116MP0005376_homeostasis/metabolism_phenot0.18341918
117MP0009672_abnormal_birth_weight0.16713540
118MP0003385_abnormal_body_wall0.16215689
119MP0004858_abnormal_nervous_system0.16053579
120MP0001727_abnormal_embryo_implantation0.16020169
121MP0001853_heart_inflammation0.15395547
122MP0002066_abnormal_motor_capabilities/c0.15154561
123MP0005535_abnormal_body_temperature0.14644086
124MP0003959_abnormal_lean_body0.13339477
125MP0003011_delayed_dark_adaptation0.13144551

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.77066847
2Exercise-induced muscle cramps (HP:0003710)7.61212846
3Calf muscle hypertrophy (HP:0008981)6.91770511
4Muscle hypertrophy of the lower extremities (HP:0008968)6.85066482
5Muscle fiber inclusion bodies (HP:0100299)6.31435670
6Sudden death (HP:0001699)6.25844290
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.20682655
8Muscle fiber splitting (HP:0003555)5.74681909
9Nemaline bodies (HP:0003798)5.64207078
10Myoglobinuria (HP:0002913)5.48575741
11Type 1 muscle fiber predominance (HP:0003803)5.37832865
12Hyporeflexia of lower limbs (HP:0002600)5.36570867
13Abnormality of the calf musculature (HP:0001430)5.28015467
14Ventricular tachycardia (HP:0004756)5.17823891
15Subaortic stenosis (HP:0001682)4.84777458
16Abnormality of the left ventricular outflow tract (HP:0011103)4.84777458
17EMG: myopathic abnormalities (HP:0003458)4.79329169
18Distal arthrogryposis (HP:0005684)4.64662889
19Difficulty running (HP:0009046)4.60642594
20Increased connective tissue (HP:0009025)4.52002169
21Rhabdomyolysis (HP:0003201)4.45621190
22Atrial fibrillation (HP:0005110)4.12062598
23Lipoatrophy (HP:0100578)4.11644316
24Round ear (HP:0100830)3.98801999
25Myopathic facies (HP:0002058)3.93941662
26Myotonia (HP:0002486)3.93089909
27Primary atrial arrhythmia (HP:0001692)3.83779820
28Asymmetric septal hypertrophy (HP:0001670)3.79527107
29Right ventricular cardiomyopathy (HP:0011663)3.76890989
30Supraventricular tachycardia (HP:0004755)3.70929490
31Muscle stiffness (HP:0003552)3.66027095
32Supraventricular arrhythmia (HP:0005115)3.63196838
33Ulnar deviation of the wrist (HP:0003049)3.52190710
34Dilated cardiomyopathy (HP:0001644)3.51523456
35Difficulty climbing stairs (HP:0003551)3.37410608
36Neck muscle weakness (HP:0000467)3.32863277
37Abnormality of skeletal muscle fiber size (HP:0012084)3.30446930
38Palpitations (HP:0001962)3.29392330
39Bundle branch block (HP:0011710)3.25802727
40Fetal akinesia sequence (HP:0001989)3.21050824
41Increased variability in muscle fiber diameter (HP:0003557)3.13937120
42Syncope (HP:0001279)3.13790594
43Prolonged QT interval (HP:0001657)3.10351824
44Ventricular arrhythmia (HP:0004308)3.02445691
45Areflexia of lower limbs (HP:0002522)2.96686327
46Distal lower limb muscle weakness (HP:0009053)2.95206060
47Calcaneovalgus deformity (HP:0001848)2.93271355
48Rimmed vacuoles (HP:0003805)2.92660241
49Popliteal pterygium (HP:0009756)2.73681420
50Absent phalangeal crease (HP:0006109)2.73511077
51Heart block (HP:0012722)2.71300544
52Deformed tarsal bones (HP:0008119)2.71134294
53Abnormal atrioventricular conduction (HP:0005150)2.60696505
54Mildly elevated creatine phosphokinase (HP:0008180)2.48403312
55EMG: neuropathic changes (HP:0003445)2.46755097
56Generalized muscle weakness (HP:0003324)2.46049881
57Type 2 muscle fiber atrophy (HP:0003554)2.44150840
58Frequent falls (HP:0002359)2.42947353
59Atrioventricular block (HP:0001678)2.41738556
60Ventricular fibrillation (HP:0001663)2.39315059
61Abnormal mitochondria in muscle tissue (HP:0008316)2.38346503
62Limb-girdle muscle atrophy (HP:0003797)2.36869500
63Acute necrotizing encephalopathy (HP:0006965)2.33735000
64Malignant hyperthermia (HP:0002047)2.29803889
65Hip contracture (HP:0003273)2.29582421
66Gowers sign (HP:0003391)2.26789792
67Muscular dystrophy (HP:0003560)2.26089105
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.25675470
69Muscle fiber atrophy (HP:0100295)2.23465469
70Left ventricular hypertrophy (HP:0001712)2.23248767
71Abnormal finger flexion creases (HP:0006143)2.21414841
72Abnormal EKG (HP:0003115)2.20934136
73Hypoplastic ischia (HP:0003175)2.18112529
74Hepatic necrosis (HP:0002605)2.16046194
75Scapular winging (HP:0003691)2.14802210
76Conjunctival hamartoma (HP:0100780)2.14381152
77Palmoplantar keratoderma (HP:0000982)2.08045198
78Distal lower limb amyotrophy (HP:0008944)2.07476655
79Facial diplegia (HP:0001349)2.06968502
80Spinal rigidity (HP:0003306)2.06607598
81Abnormality of the neuromuscular junction (HP:0003398)2.05586270
82Fatigable weakness (HP:0003473)2.05586270
83Waddling gait (HP:0002515)2.03894573
84Amniotic constriction ring (HP:0009775)2.03566438
85Abnormality of placental membranes (HP:0011409)2.03566438
86Hyperkalemia (HP:0002153)2.01299514
87Respiratory insufficiency due to muscle weakness (HP:0002747)1.99909458
88Acute encephalopathy (HP:0006846)1.95942293
89Proximal amyotrophy (HP:0007126)1.95100998
90Progressive macrocephaly (HP:0004481)1.91086087
91* Exercise intolerance (HP:0003546)1.90570577
92Abnormality of the foot musculature (HP:0001436)1.90037037
93Metatarsus adductus (HP:0001840)1.89488273
94Bulbar palsy (HP:0001283)1.88883093
95Limb-girdle muscle weakness (HP:0003325)1.88419630
96Abnormality of the ischium (HP:0003174)1.88098308
97Ketoacidosis (HP:0001993)1.87534957
98Progressive muscle weakness (HP:0003323)1.87368834
99Hepatocellular necrosis (HP:0001404)1.86855644
100Foot dorsiflexor weakness (HP:0009027)1.86103686
101Weak cry (HP:0001612)1.84600458
102Increased muscle lipid content (HP:0009058)1.84287798
103Lower limb amyotrophy (HP:0007210)1.84266215
104Ragged-red muscle fibers (HP:0003200)1.83200924
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82445264
106Mitochondrial inheritance (HP:0001427)1.82358928
107Nonprogressive disorder (HP:0003680)1.81405741
108Testicular atrophy (HP:0000029)1.76435928
109Increased CSF lactate (HP:0002490)1.75924410
110Abnormality of the shoulder girdle musculature (HP:0001435)1.72377307
111Abnormality of the hip-girdle musculature (HP:0001445)1.72129538
112Abnormality of the musculature of the pelvis (HP:0001469)1.72129538
113Abnormality of the calcaneus (HP:0008364)1.71939762
114Hypoglycemic coma (HP:0001325)1.71768873
115Long clavicles (HP:0000890)1.71296160
116Slender build (HP:0001533)1.70497928
117Shoulder girdle muscle weakness (HP:0003547)1.65400143
118Pelvic girdle muscle weakness (HP:0003749)1.62044421
119Easy fatigability (HP:0003388)1.61006266
120Aplasia of the musculature (HP:0100854)1.58364562
121Ulnar deviation of finger (HP:0009465)1.57852330
122Limited hip movement (HP:0008800)1.55383787
123Increased intramyocellular lipid droplets (HP:0012240)1.50407739
124Paralysis (HP:0003470)1.48948164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.08769589
2TTN6.44832807
3PHKG14.60996591
4PHKG24.60996591
5PDK43.12114918
6PDK33.12114918
7DMPK2.69539559
8MYLK2.66903696
9TRIB32.64229648
10NEK12.49677447
11PKN22.42973282
12PIK3CA2.36600775
13BCKDK2.07583572
14LMTK22.07213538
15STK242.02771368
16MUSK1.96387474
17PINK11.95681878
18PIK3CG1.92080165
19NME11.91869700
20PDK21.90064971
21MAP2K31.78333999
22MAP3K71.48377028
23ZAK1.29867648
24CCNB11.26894403
25TIE11.26813900
26MAPK121.21843236
27ILK1.19832168
28TRPM71.04582826
29MAPKAPK31.01636384
30MOS0.96882013
31MARK10.94789469
32PRKAA20.89019631
33STK38L0.87165540
34MAP3K30.86717962
35PRKD10.85209321
36PRKAA10.85078635
37PAK30.81389485
38ROCK10.79694763
39CAMK2D0.78024034
40NEK90.77258360
41GRK70.77024187
42FLT30.70683179
43MAP3K50.69361989
44RIPK10.69279230
45CDC42BPA0.68067262
46DYRK1B0.67847899
47ERBB30.64558129
48MAP2K60.60410785
49MAP3K130.55819300
50LIMK10.54860484
51STK40.53998583
52MAP3K100.53851926
53MAPK40.52141370
54MAP2K40.51561448
55PKN10.50933942
56KDR0.48905518
57AKT20.46864696
58INSRR0.44522959
59PDGFRA0.44016103
60ROCK20.43641860
61DAPK30.43040396
62PRKACB0.42098695
63CAMK2G0.41950841
64NME20.40848338
65PTK2B0.40360307
66CAMK2B0.40183966
67EPHB10.39149831
68PTK60.38252294
69CAMK40.38143100
70KSR20.37018341
71WNK40.36933244
72TGFBR20.36652028
73LATS10.34818453
74SIK10.34366798
75SGK30.32301868
76MAPK110.32113067
77WNK10.30333074
78TBK10.30136509
79ARAF0.29576203
80RPS6KC10.29060733
81RPS6KL10.29060733
82PRKACA0.28934134
83CAMK2A0.28123080
84LRRK20.26854482
85STK380.26510112
86MAP3K110.26171125
87CAMK10.24233986
88ICK0.23699985
89TAOK20.23612678
90RPS6KA60.23019791
91RPS6KB10.22827343
92PRKG10.22397174
93RPS6KA10.21451249
94PRKACG0.21352874
95PDPK10.20868789
96MAPK130.20345222
97SGK20.19919489
98LATS20.19817487
99MAPK100.18547074
100RPS6KB20.18478758
101MTOR0.18181709
102SGK10.17713808
103PRKD30.17028965
104MARK20.16949198
105PDK10.16285822
106TAOK10.15904888
107RPS6KA30.14521107
108FER0.13852836
109RAF10.13501990
110MAPK70.12305405
111MAPKAPK20.12159952
112EPHB20.12055737
113MAP2K10.11145977
114FGFR10.10898963
115ZAP700.09548367
116PRKG20.07945543
117EEF2K0.07877367
118STK110.07645218
119PRKCH0.07574270
120MAP3K10.07522896
121MARK30.07475902
122DAPK20.07006309
123MAP3K60.06522940
124CDK190.06085418
125BRAF0.05660281
126RPS6KA20.04421452
127SGK4940.03409802
128SGK2230.03409802
129VRK20.02879743
130MAPK90.02664048

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.91403618
2Cardiac muscle contraction_Homo sapiens_hsa042604.57796437
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.18189941
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.15099330
5Dilated cardiomyopathy_Homo sapiens_hsa054143.96554149
6Parkinsons disease_Homo sapiens_hsa050123.20557086
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.04266207
8Oxidative phosphorylation_Homo sapiens_hsa001902.97926930
9Propanoate metabolism_Homo sapiens_hsa006402.92830317
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81390626
11Alzheimers disease_Homo sapiens_hsa050102.40154482
12* Carbon metabolism_Homo sapiens_hsa012002.39441340
13Fatty acid degradation_Homo sapiens_hsa000712.39078656
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22078440
15Huntingtons disease_Homo sapiens_hsa050161.94753203
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90318920
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82819373
18Fatty acid metabolism_Homo sapiens_hsa012121.75842755
19Pyruvate metabolism_Homo sapiens_hsa006201.74804117
20Viral myocarditis_Homo sapiens_hsa054161.74317674
21Starch and sucrose metabolism_Homo sapiens_hsa005001.55483302
22* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44531350
23Glucagon signaling pathway_Homo sapiens_hsa049221.43544573
24Insulin resistance_Homo sapiens_hsa049311.36580849
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34580718
26Insulin signaling pathway_Homo sapiens_hsa049101.26096118
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.15729781
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09710253
29* Biosynthesis of amino acids_Homo sapiens_hsa012301.09368673
30Galactose metabolism_Homo sapiens_hsa000521.04666273
31Oxytocin signaling pathway_Homo sapiens_hsa049211.03275450
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00742742
33Focal adhesion_Homo sapiens_hsa045100.95526755
34Nitrogen metabolism_Homo sapiens_hsa009100.93912128
35AMPK signaling pathway_Homo sapiens_hsa041520.93739898
36Tight junction_Homo sapiens_hsa045300.93489096
37Calcium signaling pathway_Homo sapiens_hsa040200.92592275
38Fructose and mannose metabolism_Homo sapiens_hsa000510.90529602
39Fatty acid elongation_Homo sapiens_hsa000620.89808700
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88852624
41Butanoate metabolism_Homo sapiens_hsa006500.83640059
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.78538380
43PPAR signaling pathway_Homo sapiens_hsa033200.77284153
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.74905124
45Circadian rhythm_Homo sapiens_hsa047100.73793071
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70742491
47Arginine and proline metabolism_Homo sapiens_hsa003300.70700616
48Long-term potentiation_Homo sapiens_hsa047200.67705815
49* HIF-1 signaling pathway_Homo sapiens_hsa040660.67105820
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64271991
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61043533
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58679843
53beta-Alanine metabolism_Homo sapiens_hsa004100.52442042
54Adherens junction_Homo sapiens_hsa045200.51786068
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49907410
56Phenylalanine metabolism_Homo sapiens_hsa003600.49269380
57Lysine degradation_Homo sapiens_hsa003100.47212347
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46794997
59Arginine biosynthesis_Homo sapiens_hsa002200.46480672
60ECM-receptor interaction_Homo sapiens_hsa045120.45589174
61Type II diabetes mellitus_Homo sapiens_hsa049300.44078959
62Tryptophan metabolism_Homo sapiens_hsa003800.41431170
63Fatty acid biosynthesis_Homo sapiens_hsa000610.40920931
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.39108233
65Gastric acid secretion_Homo sapiens_hsa049710.38597797
66Salivary secretion_Homo sapiens_hsa049700.36707131
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36364821
68Renin secretion_Homo sapiens_hsa049240.35468137
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35290916
70Amoebiasis_Homo sapiens_hsa051460.35089930
71Proteoglycans in cancer_Homo sapiens_hsa052050.34870892
72Pentose phosphate pathway_Homo sapiens_hsa000300.34383259
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32638653
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31540067
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30592179
76mTOR signaling pathway_Homo sapiens_hsa041500.28966814
77Peroxisome_Homo sapiens_hsa041460.28807447
78FoxO signaling pathway_Homo sapiens_hsa040680.27438524
79GnRH signaling pathway_Homo sapiens_hsa049120.25336287
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25145956
81Platelet activation_Homo sapiens_hsa046110.24351217
82VEGF signaling pathway_Homo sapiens_hsa043700.23120588
83Amphetamine addiction_Homo sapiens_hsa050310.22674184
84Insulin secretion_Homo sapiens_hsa049110.20763430
85Regulation of autophagy_Homo sapiens_hsa041400.20642653
86cAMP signaling pathway_Homo sapiens_hsa040240.20298817
87* Metabolic pathways_Homo sapiens_hsa011000.20123672
88Sulfur relay system_Homo sapiens_hsa041220.19877296
89Histidine metabolism_Homo sapiens_hsa003400.18556574
90Tyrosine metabolism_Homo sapiens_hsa003500.17302732
91Purine metabolism_Homo sapiens_hsa002300.17279900
92Long-term depression_Homo sapiens_hsa047300.17145986
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16479660
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.15611654
95Renal cell carcinoma_Homo sapiens_hsa052110.14851282
96MAPK signaling pathway_Homo sapiens_hsa040100.14347853
97Phototransduction_Homo sapiens_hsa047440.13689705
98Bile secretion_Homo sapiens_hsa049760.13592478
99Olfactory transduction_Homo sapiens_hsa047400.11188015
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11105872
101Glioma_Homo sapiens_hsa052140.10375578
102Toxoplasmosis_Homo sapiens_hsa051450.09962172
103Fat digestion and absorption_Homo sapiens_hsa049750.09634169
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.08487637
105Small cell lung cancer_Homo sapiens_hsa052220.06332699
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.06277668
107Pancreatic secretion_Homo sapiens_hsa049720.00178529
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0665591
109Notch signaling pathway_Homo sapiens_hsa04330-0.0621502
110alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0601015
111Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0597094
112HTLV-I infection_Homo sapiens_hsa05166-0.0576571
113Cholinergic synapse_Homo sapiens_hsa04725-0.0571811
114Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0471530
115Gap junction_Homo sapiens_hsa04540-0.0387967
116Acute myeloid leukemia_Homo sapiens_hsa05221-0.0286674
117Melanogenesis_Homo sapiens_hsa04916-0.0273348
118PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0243352
119Circadian entrainment_Homo sapiens_hsa04713-0.0022707

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