ENOPH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.30700329
2central nervous system myelination (GO:0022010)9.30700329
3fatty acid elongation (GO:0030497)6.47576691
4long-chain fatty acid biosynthetic process (GO:0042759)5.52912828
5myelination (GO:0042552)5.01321411
6axon ensheathment (GO:0008366)4.99601372
7ensheathment of neurons (GO:0007272)4.99601372
8protein neddylation (GO:0045116)4.83395744
9cholesterol biosynthetic process (GO:0006695)4.59259708
10sterol biosynthetic process (GO:0016126)4.16105693
11establishment of mitochondrion localization (GO:0051654)4.11253471
12response to redox state (GO:0051775)4.05722045
13isoprenoid biosynthetic process (GO:0008299)3.91315139
14regulation of collateral sprouting (GO:0048670)3.83380066
15chaperone-mediated protein transport (GO:0072321)3.79581067
16negative regulation of neurotransmitter transport (GO:0051589)3.79315856
17cullin deneddylation (GO:0010388)3.76030788
18myelin maintenance (GO:0043217)3.57081217
19* L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53552523
20glycerophospholipid catabolic process (GO:0046475)3.48402067
21substantia nigra development (GO:0021762)3.47844300
22GPI anchor biosynthetic process (GO:0006506)3.45614671
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44483870
24presynaptic membrane organization (GO:0097090)3.41620005
25protein deneddylation (GO:0000338)3.41270064
26amyloid precursor protein metabolic process (GO:0042982)3.37939157
27proteasome assembly (GO:0043248)3.35722528
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31399352
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.30757392
30neurotransmitter uptake (GO:0001504)3.29702676
31negative regulation of neurotransmitter secretion (GO:0046929)3.28861344
32peptidyl-arginine omega-N-methylation (GO:0035247)3.21614312
337-methylguanosine mRNA capping (GO:0006370)3.20278819
34termination of RNA polymerase III transcription (GO:0006386)3.20202540
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.20202540
36synaptic vesicle maturation (GO:0016188)3.19269670
37RNA capping (GO:0036260)3.18932576
387-methylguanosine RNA capping (GO:0009452)3.18932576
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16319455
40ATP synthesis coupled proton transport (GO:0015986)3.16319455
41GPI anchor metabolic process (GO:0006505)3.08785560
42presynaptic membrane assembly (GO:0097105)3.06301424
43positive regulation of oligodendrocyte differentiation (GO:0048714)3.06265495
44glutamate secretion (GO:0014047)3.05999300
45nuclear envelope reassembly (GO:0031468)3.05658334
46mitotic nuclear envelope reassembly (GO:0007084)3.05658334
47oligodendrocyte differentiation (GO:0048709)3.05442580
48peptidyl-arginine methylation (GO:0018216)3.04342752
49peptidyl-arginine N-methylation (GO:0035246)3.04342752
50establishment of integrated proviral latency (GO:0075713)3.03433191
51synaptic vesicle exocytosis (GO:0016079)3.03196987
52negative regulation of protein localization to cell surface (GO:2000009)3.02713279
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99508218
54microtubule polymerization or depolymerization (GO:0031109)2.97596536
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95049961
56histone arginine methylation (GO:0034969)2.92917390
57regulation of synaptic vesicle exocytosis (GO:2000300)2.92878625
58DNA ligation (GO:0006266)2.91729995
59serine family amino acid biosynthetic process (GO:0009070)2.91089573
60CENP-A containing nucleosome assembly (GO:0034080)2.88631203
61preassembly of GPI anchor in ER membrane (GO:0016254)2.88552827
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88280413
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.88280413
64NADH dehydrogenase complex assembly (GO:0010257)2.88280413
65ribosome assembly (GO:0042255)2.87661667
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87439336
67IMP biosynthetic process (GO:0006188)2.85692335
68long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.85277767
69mannosylation (GO:0097502)2.84079574
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83480038
71negative regulation of ligase activity (GO:0051352)2.83480038
72astrocyte development (GO:0014002)2.83383502
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.81790308
74apical protein localization (GO:0045176)2.80996445
75peptidyl-cysteine modification (GO:0018198)2.79589918
76DNA damage response, detection of DNA damage (GO:0042769)2.76185827
77chromatin remodeling at centromere (GO:0031055)2.76123751
78mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.75346621
79establishment of viral latency (GO:0019043)2.75110108
80folic acid-containing compound biosynthetic process (GO:0009396)2.75075326
81L-amino acid import (GO:0043092)2.74991225
82positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.74314667
83mitotic metaphase plate congression (GO:0007080)2.72642899
84peptidyl-histidine modification (GO:0018202)2.72622928
85pteridine-containing compound biosynthetic process (GO:0042559)2.71205696
86magnesium ion transport (GO:0015693)2.70090982
87histone H2B ubiquitination (GO:0033523)2.69983958
88protein targeting to mitochondrion (GO:0006626)2.68490020
89establishment of protein localization to mitochondrion (GO:0072655)2.67883652
90positive regulation of mitochondrial fission (GO:0090141)2.67823007
91negative regulation of execution phase of apoptosis (GO:1900118)2.65914220
92deoxyribonucleotide biosynthetic process (GO:0009263)2.65905189
93response to methylmercury (GO:0051597)2.64387043
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63864680
95neuron cell-cell adhesion (GO:0007158)2.63696195
96L-serine metabolic process (GO:0006563)2.63176279
97DNA strand elongation (GO:0022616)2.62402200
98DNA unwinding involved in DNA replication (GO:0006268)2.61600262
99de novo protein folding (GO:0006458)2.59559732
100protein localization to synapse (GO:0035418)2.58862686
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.58527745
102postsynaptic membrane organization (GO:0001941)2.57479159
103protein complex biogenesis (GO:0070271)2.57121112
104tRNA aminoacylation for protein translation (GO:0006418)2.56470966
105protein palmitoylation (GO:0018345)2.56393463
106regulation of cellular amino acid metabolic process (GO:0006521)2.56078586
107vocalization behavior (GO:0071625)2.56042148
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.55313017
109purine nucleobase biosynthetic process (GO:0009113)2.55173518
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55037900
111protein complex localization (GO:0031503)2.54676811
112neurotransmitter secretion (GO:0007269)2.53749663
113regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.53511142
114de novo posttranslational protein folding (GO:0051084)2.53495076
115regulation of mitochondrial translation (GO:0070129)2.52364641
116telomere maintenance via semi-conservative replication (GO:0032201)2.52159003
117DNA double-strand break processing (GO:0000729)2.51952230
118tRNA aminoacylation (GO:0043039)2.51793921
119amino acid activation (GO:0043038)2.51793921
120regulation of cofactor metabolic process (GO:0051193)2.51631019
121regulation of coenzyme metabolic process (GO:0051196)2.51631019
122negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.51555001
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.50204722
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.50204722
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.47943309
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.47943309
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.47943309
128glial cell development (GO:0021782)2.46876239
129spliceosomal snRNP assembly (GO:0000387)2.45201952
130* L-methionine salvage (GO:0071267)2.45157965
131* L-methionine biosynthetic process (GO:0071265)2.45157965
132* amino acid salvage (GO:0043102)2.45157965
133IMP metabolic process (GO:0046040)2.44773500
134negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44697094
135DNA strand elongation involved in DNA replication (GO:0006271)2.44398431
136negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44374543
137adult walking behavior (GO:0007628)2.42615954
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.42248241
139negative regulation of sister chromatid segregation (GO:0033046)2.42248241
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.42248241
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.42248241
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.42248241
143transcription elongation from RNA polymerase I promoter (GO:0006362)2.41912895
144signal transduction involved in DNA integrity checkpoint (GO:0072401)2.41845475
145signal transduction involved in DNA damage checkpoint (GO:0072422)2.41845475
146protein-cofactor linkage (GO:0018065)2.40796312
147tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40591445
148RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40591445
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40396202
150negative regulation of DNA recombination (GO:0045910)2.39017676
151GTP biosynthetic process (GO:0006183)2.38792570
152negative regulation of chromosome segregation (GO:0051985)2.38619123
153amino acid import (GO:0043090)2.37885628
154layer formation in cerebral cortex (GO:0021819)2.37364724
155positive regulation of dendritic spine morphogenesis (GO:0061003)2.36227971
156DNA replication-independent nucleosome organization (GO:0034724)2.35773406
157DNA replication-independent nucleosome assembly (GO:0006336)2.35773406
158protein localization to chromosome, centromeric region (GO:0071459)2.34134047
159mitotic spindle checkpoint (GO:0071174)2.34022690
160histone exchange (GO:0043486)2.33889947
161regulation of helicase activity (GO:0051095)2.32900122
162mitochondrion transport along microtubule (GO:0047497)2.31355227
163establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.31355227
164regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31136732
165mitotic spindle assembly checkpoint (GO:0007094)2.30830764
166protein localization to kinetochore (GO:0034501)2.30525349
167cellular potassium ion homeostasis (GO:0030007)2.28676239
168double-strand break repair via nonhomologous end joining (GO:0006303)2.28341807
169non-recombinational repair (GO:0000726)2.28341807
1702-deoxyribonucleotide biosynthetic process (GO:0009265)2.28300430
171deoxyribose phosphate biosynthetic process (GO:0046385)2.28300430
172gamma-aminobutyric acid transport (GO:0015812)2.27864486
173spindle assembly checkpoint (GO:0071173)2.27499233
174spindle checkpoint (GO:0031577)2.26941049
175regulation of synaptic vesicle transport (GO:1902803)2.25323007
176cellular protein complex localization (GO:0034629)2.22299987
177mitochondrial fission (GO:0000266)2.22086410
178synaptic vesicle endocytosis (GO:0048488)2.21042603
179tricarboxylic acid cycle (GO:0006099)2.18693655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.11219004
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.09508041
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.63708706
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26449959
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.79603210
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.66184104
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.58922179
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40283038
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.25875121
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.24424784
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.08268782
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06240623
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79748872
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78957770
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.61080465
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.60011657
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54184865
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36817362
19VDR_23849224_ChIP-Seq_CD4+_Human2.08905851
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08843778
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07085340
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.02808736
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00867757
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.89637006
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87027204
26E2F7_22180533_ChIP-Seq_HELA_Human1.85315034
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82669851
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.81112291
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80102780
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79409827
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75696622
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72281183
33DCP1A_22483619_ChIP-Seq_HELA_Human1.68013898
34XRN2_22483619_ChIP-Seq_HELA_Human1.67540040
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67049548
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62112947
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.61775355
38IGF1R_20145208_ChIP-Seq_DFB_Human1.58901499
39TAF15_26573619_Chip-Seq_HEK293_Human1.55978900
40FOXP3_21729870_ChIP-Seq_TREG_Human1.55627692
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52111882
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.51759929
43GABP_19822575_ChIP-Seq_HepG2_Human1.50916942
44* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50147275
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50103145
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48397527
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46410901
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45257614
49IRF1_19129219_ChIP-ChIP_H3396_Human1.44490722
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43538331
51GBX2_23144817_ChIP-Seq_PC3_Human1.41615031
52* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41325583
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40949491
54ELK1_19687146_ChIP-ChIP_HELA_Human1.40689953
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39938958
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36112742
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35853235
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35853235
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35853235
60TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.34193494
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33716275
62CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.32469347
63FUS_26573619_Chip-Seq_HEK293_Human1.31879743
64VDR_22108803_ChIP-Seq_LS180_Human1.30757826
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30086441
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29913085
67TTF2_22483619_ChIP-Seq_HELA_Human1.28379383
68REST_19997604_ChIP-ChIP_NEURONS_Mouse1.26859111
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26305209
70* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24909459
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22068510
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20428603
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20198530
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20116825
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19646055
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18102712
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17380328
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.16859109
79ZNF263_19887448_ChIP-Seq_K562_Human1.16662312
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15769311
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15533745
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14809230
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13777621
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13645613
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09169123
86MYC_18940864_ChIP-ChIP_HL60_Human1.09014048
87EOMES_21245162_ChIP-Seq_HESCs_Human1.06539911
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.05478118
89EWS_26573619_Chip-Seq_HEK293_Human1.05418507
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.03503641
91ER_23166858_ChIP-Seq_MCF-7_Human1.00492735
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99712250
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.98657379
94* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98614141
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98382185
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.98194736
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97240842
98ZNF274_21170338_ChIP-Seq_K562_Hela0.97052193
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.94565055
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94271849
101ELK1_22589737_ChIP-Seq_MCF10A_Human0.93528463
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93501660
103SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93185920
104WT1_19549856_ChIP-ChIP_CCG9911_Human0.92518326
105FLI1_27457419_Chip-Seq_LIVER_Mouse0.91877363
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91771077
107SOX9_26525672_Chip-Seq_HEART_Mouse0.90879009
108P300_19829295_ChIP-Seq_ESCs_Human0.90773180
109REST_21632747_ChIP-Seq_MESCs_Mouse0.89365655
110* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89194728
111KDM5A_27292631_Chip-Seq_BREAST_Human0.88092009
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85251683
113LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84333753
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83600014
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82893147
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81683296
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78843683
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78204662
119YY1_22570637_ChIP-Seq_MALME-3M_Human0.78144760
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75732052
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75097916
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74801802
123* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74777811
124CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74702654
125* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.74320230
126AR_21909140_ChIP-Seq_LNCAP_Human0.73972575
127SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.73469571
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73459064
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.72745786
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.70308921
131STAT1_20625510_ChIP-Seq_HELA_Human0.70280145
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.68215954
133SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.67311623
134HTT_18923047_ChIP-ChIP_STHdh_Human0.66618004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.09778289
2MP0000920_abnormal_myelination4.08684174
3MP0001529_abnormal_vocalization3.65265936
4MP0001905_abnormal_dopamine_level3.19340542
5MP0003950_abnormal_plasma_membrane2.69199481
6MP0004270_analgesia2.62046575
7MP0003136_yellow_coat_color2.54330148
8MP0004142_abnormal_muscle_tone2.37194381
9MP0003806_abnormal_nucleotide_metabolis2.33961373
10MP0002272_abnormal_nervous_system2.31761913
11MP0008260_abnormal_autophagy2.25160565
12MP0003329_amyloid_beta_deposits2.17783509
13MP0005171_absent_coat_pigmentation2.13322959
14MP0008057_abnormal_DNA_replication2.05832941
15MP0002064_seizures2.05604702
16MP0003693_abnormal_embryo_hatching2.03802936
17MP0001486_abnormal_startle_reflex1.99170148
18MP0004742_abnormal_vestibular_system1.97530526
19MP0001986_abnormal_taste_sensitivity1.93334513
20MP0005410_abnormal_fertilization1.86708399
21MP0009046_muscle_twitch1.82088008
22MP0003718_maternal_effect1.79440763
23MP0003634_abnormal_glial_cell1.78300730
24MP0001485_abnormal_pinna_reflex1.74074692
25MP0003941_abnormal_skin_development1.73629416
26MP0003122_maternal_imprinting1.73440397
27MP0003123_paternal_imprinting1.72591082
28MP0004859_abnormal_synaptic_plasticity1.71952990
29MP0003690_abnormal_glial_cell1.66375496
30MP0002229_neurodegeneration1.63630498
31MP0003787_abnormal_imprinting1.63145718
32MP0002734_abnormal_mechanical_nocicepti1.62914027
33MP0000778_abnormal_nervous_system1.62445549
34MP0003632_abnormal_nervous_system1.62166800
35MP0003635_abnormal_synaptic_transmissio1.58488007
36MP0003121_genomic_imprinting1.58390389
37MP0002653_abnormal_ependyma_morphology1.57030007
38MP0008932_abnormal_embryonic_tissue1.56208115
39MP0009745_abnormal_behavioral_response1.54981590
40MP0010234_abnormal_vibrissa_follicle1.52854849
41MP0002736_abnormal_nociception_after1.52423449
42MP0002090_abnormal_vision1.52219448
43MP0005423_abnormal_somatic_nervous1.48228818
44MP0008877_abnormal_DNA_methylation1.47597609
45MP0002572_abnormal_emotion/affect_behav1.45958949
46MP0005409_darkened_coat_color1.45673533
47MP0001968_abnormal_touch/_nociception1.45473193
48MP0004957_abnormal_blastocyst_morpholog1.45052037
49MP0005394_taste/olfaction_phenotype1.44849397
50MP0005499_abnormal_olfactory_system1.44849397
51MP0003890_abnormal_embryonic-extraembry1.41398491
52MP0004885_abnormal_endolymph1.37772372
53MP0002063_abnormal_learning/memory/cond1.36149009
54MP0005551_abnormal_eye_electrophysiolog1.34911694
55MP0004133_heterotaxia1.31605214
56MP0001970_abnormal_pain_threshold1.26550993
57MP0001177_atelectasis1.26199062
58MP0008058_abnormal_DNA_repair1.25833736
59MP0002163_abnormal_gland_morphology1.24724774
60MP0006292_abnormal_olfactory_placode1.21781417
61MP0002882_abnormal_neuron_morphology1.21128909
62MP0000537_abnormal_urethra_morphology1.20995922
63MP0005187_abnormal_penis_morphology1.20904875
64MP0002067_abnormal_sensory_capabilities1.19713672
65MP0003631_nervous_system_phenotype1.19124917
66MP0005248_abnormal_Harderian_gland1.16547880
67MP0001440_abnormal_grooming_behavior1.16547374
68MP0004043_abnormal_pH_regulation1.15565004
69MP0001984_abnormal_olfaction1.15377105
70MP0003221_abnormal_cardiomyocyte_apopto1.14243767
71MP0002909_abnormal_adrenal_gland1.13765642
72MP0002752_abnormal_somatic_nervous1.12221404
73MP0004134_abnormal_chest_morphology1.12068419
74MP0009672_abnormal_birth_weight1.11795843
75MP0002066_abnormal_motor_capabilities/c1.11477620
76MP0008789_abnormal_olfactory_epithelium1.10333354
77MP0005386_behavior/neurological_phenoty1.10180713
78MP0004924_abnormal_behavior1.10180713
79MP0010094_abnormal_chromosome_stability1.08284305
80MP0001963_abnormal_hearing_physiology1.07137028
81MP0000955_abnormal_spinal_cord1.06039477
82MP0009697_abnormal_copulation1.05849037
83MP0004147_increased_porphyrin_level1.05171649
84MP0002557_abnormal_social/conspecific_i1.03637417
85MP0000462_abnormal_digestive_system1.03424719
86MP0000647_abnormal_sebaceous_gland1.02096423
87MP0000566_synostosis1.00285588
88MP0002638_abnormal_pupillary_reflex0.99715085
89MP0006072_abnormal_retinal_apoptosis0.98453092
90MP0001188_hyperpigmentation0.97905565
91MP0005646_abnormal_pituitary_gland0.97489267
92MP0010352_gastrointestinal_tract_polyps0.96529964
93MP0002822_catalepsy0.94245159
94MP0003938_abnormal_ear_development0.93965781
95MP0000516_abnormal_urinary_system0.93094768
96MP0005367_renal/urinary_system_phenotyp0.93094768
97MP0008007_abnormal_cellular_replicative0.92962602
98MP0004381_abnormal_hair_follicle0.92553316
99MP0004233_abnormal_muscle_weight0.92247757
100MP0002733_abnormal_thermal_nociception0.92133861
101MP0005195_abnormal_posterior_eye0.91100086
102MP0003119_abnormal_digestive_system0.89453483
103MP0003183_abnormal_peptide_metabolism0.89013886
104MP0003315_abnormal_perineum_morphology0.88785925
105MP0000350_abnormal_cell_proliferation0.87521832
106MP0005253_abnormal_eye_physiology0.87393836
107MP0001299_abnormal_eye_distance/0.87122295
108MP0002084_abnormal_developmental_patter0.86735418
109MP0001502_abnormal_circadian_rhythm0.86572794
110MP0000604_amyloidosis0.86238583
111MP0003077_abnormal_cell_cycle0.85400005
112MP0002152_abnormal_brain_morphology0.83972534
113MP0008569_lethality_at_weaning0.83819871
114MP0003698_abnormal_male_reproductive0.83470303
115MP0000372_irregular_coat_pigmentation0.82569870
116MP0002735_abnormal_chemical_nociception0.82543945
117MP0000358_abnormal_cell_content/0.80700036
118MP0002233_abnormal_nose_morphology0.80650978
119MP0005623_abnormal_meninges_morphology0.79997142
120MP0001697_abnormal_embryo_size0.79963003
121MP0003633_abnormal_nervous_system0.79882499
122MP0002751_abnormal_autonomic_nervous0.79673559
123MP0002697_abnormal_eye_size0.78551551
124MP0004197_abnormal_fetal_growth/weight/0.78488207
125MP0006035_abnormal_mitochondrial_morpho0.75906841
126MP0005075_abnormal_melanosome_morpholog0.75443869
127MP0005379_endocrine/exocrine_gland_phen0.75219888
128MP0005645_abnormal_hypothalamus_physiol0.74716825
129MP0000026_abnormal_inner_ear0.72795544
130MP0003937_abnormal_limbs/digits/tail_de0.71983625
131MP0001293_anophthalmia0.71875871
132MP0001929_abnormal_gametogenesis0.69906399
133MP0003186_abnormal_redox_activity0.67758417
134MP0001730_embryonic_growth_arrest0.67755448
135MP0001727_abnormal_embryo_implantation0.66726234
136MP0002184_abnormal_innervation0.66629852
137MP0009333_abnormal_splenocyte_physiolog0.65678198
138MP0003111_abnormal_nucleus_morphology0.65010031
139MP0002938_white_spotting0.64801178
140MP0000631_abnormal_neuroendocrine_gland0.64712428
141MP0004811_abnormal_neuron_physiology0.64140075
142MP0006036_abnormal_mitochondrial_physio0.64016032
143MP0006276_abnormal_autonomic_nervous0.63966268
144MP0003861_abnormal_nervous_system0.63811580

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)5.67239092
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.99763740
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.99763740
4Abnormality of glycolysis (HP:0004366)4.89460128
5Increased serum pyruvate (HP:0003542)4.89460128
6Neurofibrillary tangles (HP:0002185)3.97900497
7Parakeratosis (HP:0001036)3.78721317
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.66623461
9Cortical dysplasia (HP:0002539)3.62155306
10CNS hypomyelination (HP:0003429)3.62051607
11Abnormality of the corticospinal tract (HP:0002492)3.54885479
12Peripheral hypomyelination (HP:0007182)3.52021794
13Leukodystrophy (HP:0002415)3.44714200
14Sensory axonal neuropathy (HP:0003390)3.41272359
15Acute necrotizing encephalopathy (HP:0006965)3.36457749
16Mitochondrial inheritance (HP:0001427)3.03084140
17Hepatocellular necrosis (HP:0001404)2.92341628
183-Methylglutaconic aciduria (HP:0003535)2.90402741
19Abnormal mitochondria in muscle tissue (HP:0008316)2.88844774
20Cerebral inclusion bodies (HP:0100314)2.82206465
21Hypoplastic pelvis (HP:0008839)2.79245624
22Postnatal microcephaly (HP:0005484)2.73450341
23Congenital ichthyosiform erythroderma (HP:0007431)2.73447953
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71754371
25Abnormality of alanine metabolism (HP:0010916)2.71754371
26Hyperalaninemia (HP:0003348)2.71754371
27Abnormality of the anterior horn cell (HP:0006802)2.68976191
28Degeneration of anterior horn cells (HP:0002398)2.68976191
29Progressive macrocephaly (HP:0004481)2.60836857
30Retinal dysplasia (HP:0007973)2.60740282
31Poor suck (HP:0002033)2.60573875
32Abnormal auditory evoked potentials (HP:0006958)2.60472067
33Urinary urgency (HP:0000012)2.57028627
34Abnormality of the labia minora (HP:0012880)2.53566942
35Increased CSF lactate (HP:0002490)2.52649488
36Absent septum pellucidum (HP:0001331)2.50964673
37Acute encephalopathy (HP:0006846)2.50422780
38Upper limb muscle weakness (HP:0003484)2.49135436
39Renal Fanconi syndrome (HP:0001994)2.49120033
40Action tremor (HP:0002345)2.48338905
41Supranuclear gaze palsy (HP:0000605)2.47345699
42Spastic gait (HP:0002064)2.46518165
43Colon cancer (HP:0003003)2.43886893
44Breast hypoplasia (HP:0003187)2.40631017
45Increased hepatocellular lipid droplets (HP:0006565)2.39348721
46Morphological abnormality of the inner ear (HP:0011390)2.37391524
47Hepatoblastoma (HP:0002884)2.34583621
48Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.32045978
49Abnormality of the septum pellucidum (HP:0007375)2.31686307
50Hypsarrhythmia (HP:0002521)2.31065001
51Termporal pattern (HP:0011008)2.29242960
52Insidious onset (HP:0003587)2.29242960
53Atrophy/Degeneration involving motor neurons (HP:0007373)2.29161628
54Epileptiform EEG discharges (HP:0011182)2.28059849
55Birth length less than 3rd percentile (HP:0003561)2.27623204
56EEG with generalized epileptiform discharges (HP:0011198)2.27581211
57Alacrima (HP:0000522)2.27247709
58Autoamputation (HP:0001218)2.27060839
59Hyperglycinemia (HP:0002154)2.23592470
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23039540
61Spastic paraparesis (HP:0002313)2.22734835
62Impaired vibration sensation in the lower limbs (HP:0002166)2.22219492
63Hypoglycemic seizures (HP:0002173)2.20648805
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20229694
65Microvesicular hepatic steatosis (HP:0001414)2.16111155
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16030194
67Heterochromia iridis (HP:0001100)2.15434248
68Ankle clonus (HP:0011448)2.14624681
69Generalized tonic-clonic seizures (HP:0002069)2.14613565
70Vaginal atresia (HP:0000148)2.10929697
71Delusions (HP:0000746)2.10417692
72Hyperinsulinemic hypoglycemia (HP:0000825)2.08452949
73Prolonged neonatal jaundice (HP:0006579)2.08437402
74Multiple enchondromatosis (HP:0005701)2.08435826
75Segmental peripheral demyelination/remyelination (HP:0003481)2.07477036
76Adrenal hypoplasia (HP:0000835)2.07137288
77Shoulder girdle muscle weakness (HP:0003547)2.06251936
78Myokymia (HP:0002411)2.05867451
79Septo-optic dysplasia (HP:0100842)2.05405498
80Spastic diplegia (HP:0001264)2.04961165
81Medulloblastoma (HP:0002885)2.04599672
82Increased serum lactate (HP:0002151)2.04072363
83Hepatic necrosis (HP:0002605)2.03128492
84Gait imbalance (HP:0002141)2.02328873
85Stenosis of the external auditory canal (HP:0000402)2.01897948
86Abnormality of the umbilical cord (HP:0010881)2.00384340
87Genital tract atresia (HP:0001827)2.00188479
88Respiratory failure (HP:0002878)1.98283125
89Hepatosplenomegaly (HP:0001433)1.97900433
90Abnormality of the lower motor neuron (HP:0002366)1.97477915
91Abnormal umbilical cord blood vessels (HP:0011403)1.96609218
92Single umbilical artery (HP:0001195)1.96609218
93Abnormality of the fetal cardiovascular system (HP:0010948)1.96609218
94Asplenia (HP:0001746)1.96292796
95Medial flaring of the eyebrow (HP:0010747)1.96065670
96Muscular hypotonia of the trunk (HP:0008936)1.95808040
97Duplicated collecting system (HP:0000081)1.95747332
98Esophageal atresia (HP:0002032)1.95497724
99Decreased lacrimation (HP:0000633)1.95438478
100Stridor (HP:0010307)1.94361663
101Split foot (HP:0001839)1.93774351
102Akinesia (HP:0002304)1.93549907
103Clumsiness (HP:0002312)1.93213954
104Amyotrophic lateral sclerosis (HP:0007354)1.92965517
105Onion bulb formation (HP:0003383)1.92786264
106Congenital primary aphakia (HP:0007707)1.91836401
107Hypoglycemic coma (HP:0001325)1.91610203
108Specific learning disability (HP:0001328)1.89976396
109Lipid accumulation in hepatocytes (HP:0006561)1.89352459
110Drooling (HP:0002307)1.89228911
111Atonic seizures (HP:0010819)1.88705938
112Epileptic encephalopathy (HP:0200134)1.88111707
113Focal motor seizures (HP:0011153)1.87810022
114Hemiparesis (HP:0001269)1.87100382
115Choreoathetosis (HP:0001266)1.86724148
116Dysmetria (HP:0001310)1.84667237
117Neoplasm of the adrenal gland (HP:0100631)1.83678897
118External ophthalmoplegia (HP:0000544)1.83092088
119Poor speech (HP:0002465)1.82850418
120Scanning speech (HP:0002168)1.80146472
121Abnormality of serum amino acid levels (HP:0003112)1.79961328
122Methylmalonic acidemia (HP:0002912)1.79631354
123Nephrogenic diabetes insipidus (HP:0009806)1.77877213
124Abnormality of the hip-girdle musculature (HP:0001445)1.76223365
125Abnormality of the musculature of the pelvis (HP:0001469)1.76223365
126Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75688214
127Intestinal atresia (HP:0011100)1.74625929
128Increased nuchal translucency (HP:0010880)1.72925267
129Optic disc pallor (HP:0000543)1.72148985
130Abnormality of cochlea (HP:0000375)1.71713762
131Abnormality of serine family amino acid metabolism (HP:0010894)1.71638442
132Abnormality of glycine metabolism (HP:0010895)1.71638442
133Pheochromocytoma (HP:0002666)1.71534491
134Abnormality of the renal collecting system (HP:0004742)1.71483700
135Anteriorly placed anus (HP:0001545)1.71311775
136Abnormality of renal resorption (HP:0011038)1.71280432
137Thickened helices (HP:0000391)1.70794462
138Progressive external ophthalmoplegia (HP:0000590)1.70560436
139Slow saccadic eye movements (HP:0000514)1.70521045
140Aplasia/Hypoplasia of the spleen (HP:0010451)1.70202881
141CNS demyelination (HP:0007305)1.69617204
142Emotional lability (HP:0000712)1.69575823
143Abnormality of the metopic suture (HP:0005556)1.69427575
144Broad foot (HP:0001769)1.68948211
145Abnormal hair whorl (HP:0010721)1.68922105
146Spastic tetraplegia (HP:0002510)1.68631101
147Papillary thyroid carcinoma (HP:0002895)1.68186152
148Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67724939
149Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67724939
150Hammertoe (HP:0001765)1.67329703
151Neuroendocrine neoplasm (HP:0100634)1.67329580
152Limb dystonia (HP:0002451)1.66195562
153Insomnia (HP:0100785)1.66190837
154Clonus (HP:0002169)1.64322454
155Polyphagia (HP:0002591)1.63260920
156Generalized myoclonic seizures (HP:0002123)1.61616564
157Absence seizures (HP:0002121)1.61120561
158Intention tremor (HP:0002080)1.60170992
159Sensorimotor neuropathy (HP:0007141)1.59913719
160Prominent metopic ridge (HP:0005487)1.59285192
161Excessive salivation (HP:0003781)1.59026759
162Lactic acidosis (HP:0003128)1.58543322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.29180416
2BUB13.62817769
3OXSR13.30158633
4MAPKAPK53.03624744
5CDK192.88492197
6MAP3K42.87956001
7TRIM282.78383251
8PBK2.63714067
9TESK22.56363831
10BCR2.55767881
11NEK12.55522546
12STK162.25912693
13CASK2.24693821
14PNCK2.05043442
15MST42.00601226
16PRPF4B1.94014503
17TSSK61.86337638
18SCYL21.83466474
19CCNB11.83191501
20NTRK21.72974435
21TAF11.72922525
22EPHB11.70606006
23ARAF1.67302625
24WEE11.65340651
25LIMK11.64283545
26MAP4K21.64129716
27CSNK1G31.63195737
28EIF2AK11.61548125
29DYRK21.60916769
30RPS6KA41.59861357
31PKN11.57907026
32MKNK11.57692202
33UHMK11.53850147
34MINK11.46220850
35VRK11.41435135
36CSNK1A1L1.34371774
37ERBB31.33395631
38CAMK2B1.23823730
39TESK11.21681697
40NEK61.18005639
41EIF2AK31.17373913
42MET1.17279737
43WNK41.16078492
44CSNK1G11.15962024
45CLK11.15610495
46WNK31.15416956
47EPHA41.12548376
48VRK21.11943021
49NME11.05916383
50TNIK1.03836661
51ROCK21.02516998
52NTRK31.01639387
53MUSK0.99706798
54TLK10.99576328
55BRAF0.99327060
56CAMK2D0.98953406
57CDK140.95658001
58CSNK1G20.95273332
59PLK30.95038013
60PRKD30.92435577
61MARK10.90237754
62BMPR1B0.88665484
63PLK20.88264725
64AKT30.86020224
65MAP2K40.85262364
66FGR0.85053486
67ZAK0.84731344
68CDK150.84013562
69CDK180.83392885
70LATS20.83136434
71RPS6KA50.82306613
72PRKCG0.81518043
73MAP3K90.79703165
74PAK10.79329703
75CDK60.78539278
76NME20.78325480
77PLK40.77868832
78CDK11A0.77474228
79FGFR20.76824735
80STK38L0.74914040
81AURKA0.71395902
82PAK60.70590765
83SGK2230.70485418
84SGK4940.70485418
85CDC70.70230576
86SRPK10.69377045
87ALK0.69190730
88ERBB40.68366629
89NTRK10.67980641
90CAMK2A0.67212409
91BRSK10.67101014
92CAMK2G0.66916856
93ADRBK20.66665726
94MAP2K70.66131793
95ATR0.65449354
96BCKDK0.64648860
97PINK10.64224630
98WNK10.61593350
99TTK0.58705688
100KSR10.58091184
101CDK50.56143739
102BMPR20.55429692
103YES10.54796615
104PASK0.53789013
105MAP3K50.53401631
106EIF2AK20.52438466
107AURKB0.51093675
108BRD40.50622092
109CDK70.49528963
110AKT20.48944235
111MAPK130.48471023
112DYRK30.46089431
113PLK10.46038827
114CHEK20.45435763
115GRK50.45333338
116PIM20.45105480
117ATM0.43464122
118CSNK1A10.43231723
119LMTK20.41496083
120DAPK30.39708542
121MAP3K120.38803742
122CSNK2A20.37923503
123DAPK10.34722644
124MKNK20.34676324
125PRKCQ0.32397408
126PRKACB0.31297274
127PRKCE0.30675273
128MAPK150.29498935
129DYRK1A0.28794378
130CSNK2A10.27967811
131CSNK1E0.27109324
132CSNK1D0.26693825
133CHEK10.25524600
134IRAK20.24729928
135ABL20.24163247
136EPHA20.22890843
137CDK80.22764761
138MAPKAPK20.21931485

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.15539514
2Proteasome_Homo sapiens_hsa030503.52916322
3Steroid biosynthesis_Homo sapiens_hsa001003.47166271
4Fatty acid elongation_Homo sapiens_hsa000623.24595891
5Oxidative phosphorylation_Homo sapiens_hsa001903.02732703
6RNA polymerase_Homo sapiens_hsa030202.98443077
7Vitamin B6 metabolism_Homo sapiens_hsa007502.77001693
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60976602
9Ether lipid metabolism_Homo sapiens_hsa005652.48660448
10Parkinsons disease_Homo sapiens_hsa050122.44497551
11Protein export_Homo sapiens_hsa030602.40219162
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33484811
13DNA replication_Homo sapiens_hsa030302.15329925
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.14617174
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07707290
16Mismatch repair_Homo sapiens_hsa034301.97644711
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95100834
18Ribosome_Homo sapiens_hsa030101.94397103
19Alzheimers disease_Homo sapiens_hsa050101.79691084
20Huntingtons disease_Homo sapiens_hsa050161.72958255
21Basal transcription factors_Homo sapiens_hsa030221.68301374
22Collecting duct acid secretion_Homo sapiens_hsa049661.66534954
23Nucleotide excision repair_Homo sapiens_hsa034201.58082322
24Spliceosome_Homo sapiens_hsa030401.57881635
25Homologous recombination_Homo sapiens_hsa034401.55636100
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55367905
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39432042
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35473348
29Vibrio cholerae infection_Homo sapiens_hsa051101.33581858
30Carbon metabolism_Homo sapiens_hsa012001.32457069
31Linoleic acid metabolism_Homo sapiens_hsa005911.31939389
32Pyrimidine metabolism_Homo sapiens_hsa002401.29679290
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22712796
34Propanoate metabolism_Homo sapiens_hsa006401.20042243
35Sphingolipid metabolism_Homo sapiens_hsa006001.18530313
36RNA transport_Homo sapiens_hsa030131.17975958
37Base excision repair_Homo sapiens_hsa034101.17409849
38Non-homologous end-joining_Homo sapiens_hsa034501.15421351
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14221571
40One carbon pool by folate_Homo sapiens_hsa006701.11191085
41Pyruvate metabolism_Homo sapiens_hsa006201.10735121
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10599194
43Purine metabolism_Homo sapiens_hsa002301.10318383
44Synaptic vesicle cycle_Homo sapiens_hsa047211.10131714
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07379055
46Serotonergic synapse_Homo sapiens_hsa047261.06290008
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04260716
48Selenocompound metabolism_Homo sapiens_hsa004501.01692238
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01000336
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96991443
51Butanoate metabolism_Homo sapiens_hsa006500.94273383
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92484307
53RNA degradation_Homo sapiens_hsa030180.89686461
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88634084
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87729257
56Arachidonic acid metabolism_Homo sapiens_hsa005900.85525887
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83919623
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83012509
59GABAergic synapse_Homo sapiens_hsa047270.82189722
60Rheumatoid arthritis_Homo sapiens_hsa053230.81492985
61Nicotine addiction_Homo sapiens_hsa050330.80328053
62Fanconi anemia pathway_Homo sapiens_hsa034600.79734373
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77806170
64Phototransduction_Homo sapiens_hsa047440.77487677
65Long-term depression_Homo sapiens_hsa047300.77379823
66Glutamatergic synapse_Homo sapiens_hsa047240.75008170
67Glutathione metabolism_Homo sapiens_hsa004800.74872834
68Cell cycle_Homo sapiens_hsa041100.74206122
69Sulfur relay system_Homo sapiens_hsa041220.71319489
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69998822
71Hippo signaling pathway_Homo sapiens_hsa043900.68161638
72Regulation of autophagy_Homo sapiens_hsa041400.67972207
73Folate biosynthesis_Homo sapiens_hsa007900.67647290
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67295907
75Sulfur metabolism_Homo sapiens_hsa009200.66297432
76Fatty acid metabolism_Homo sapiens_hsa012120.65854527
77N-Glycan biosynthesis_Homo sapiens_hsa005100.65664324
78Morphine addiction_Homo sapiens_hsa050320.65088749
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64768156
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63822600
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62837086
82Cardiac muscle contraction_Homo sapiens_hsa042600.61876967
83Arginine and proline metabolism_Homo sapiens_hsa003300.61873284
84* Metabolic pathways_Homo sapiens_hsa011000.57734582
85Insulin secretion_Homo sapiens_hsa049110.57396603
86Peroxisome_Homo sapiens_hsa041460.56377970
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56197949
88beta-Alanine metabolism_Homo sapiens_hsa004100.56129550
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56125088
90Axon guidance_Homo sapiens_hsa043600.55481312
91Phagosome_Homo sapiens_hsa041450.55455606
92Histidine metabolism_Homo sapiens_hsa003400.54845941
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52312361
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50038254
95Alcoholism_Homo sapiens_hsa050340.49936441
96Oocyte meiosis_Homo sapiens_hsa041140.49446707
97Dopaminergic synapse_Homo sapiens_hsa047280.49219442
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.48343697
99Epstein-Barr virus infection_Homo sapiens_hsa051690.44072466
100Pentose phosphate pathway_Homo sapiens_hsa000300.43233962
101p53 signaling pathway_Homo sapiens_hsa041150.42124748
102Circadian entrainment_Homo sapiens_hsa047130.41661870
103Tight junction_Homo sapiens_hsa045300.40548306
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40343794
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.40179944
106Arginine biosynthesis_Homo sapiens_hsa002200.38439526
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36981845
108mRNA surveillance pathway_Homo sapiens_hsa030150.36044902
109Renal cell carcinoma_Homo sapiens_hsa052110.35193431
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34568889
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34123493
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33860883
113Taste transduction_Homo sapiens_hsa047420.33349977
114Wnt signaling pathway_Homo sapiens_hsa043100.33282758
115Circadian rhythm_Homo sapiens_hsa047100.33076041
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31586165
117Amphetamine addiction_Homo sapiens_hsa050310.31131366
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30317792
119Autoimmune thyroid disease_Homo sapiens_hsa053200.30022009
120Ras signaling pathway_Homo sapiens_hsa040140.29918892
121Cocaine addiction_Homo sapiens_hsa050300.29175392
122Lysosome_Homo sapiens_hsa041420.27990966
123Endocytosis_Homo sapiens_hsa041440.27801774
124Olfactory transduction_Homo sapiens_hsa047400.27482828
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26414556
126Asthma_Homo sapiens_hsa053100.24848865
127Gap junction_Homo sapiens_hsa045400.22670740
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.18688710
129* Cysteine and methionine metabolism_Homo sapiens_hsa002700.17301226
130Shigellosis_Homo sapiens_hsa051310.16789923
131Long-term potentiation_Homo sapiens_hsa047200.15276903
132Hedgehog signaling pathway_Homo sapiens_hsa043400.14731838
133Cholinergic synapse_Homo sapiens_hsa047250.14350911
134Allograft rejection_Homo sapiens_hsa053300.13079083
135Ovarian steroidogenesis_Homo sapiens_hsa049130.12855226
136Biosynthesis of amino acids_Homo sapiens_hsa012300.11485022

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