ENOSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was originally identified as a naturally occurring antisense transcript to the human thymidylate synthase gene. Alternate splice variants have been described, one of which (named rTSalpha) represents an alternate 3'UTR that is complementary to the 3'UTR and terminal intron of the thymidylate synthase (TS) RNA and down-regulates TS expression. Other transcript variants (rTSbeta and rTSgamma) do not overlap the TS locus. The function of this gene appears to be primarily to regulate expression of the TS locus both via the antisense transcript as well as through the encoded proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.71406579
2meiotic chromosome segregation (GO:0045132)4.92727393
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.42114887
4drug catabolic process (GO:0042737)4.36234516
5indole-containing compound catabolic process (GO:0042436)4.03786176
6indolalkylamine catabolic process (GO:0046218)4.03786176
7tryptophan catabolic process (GO:0006569)4.03786176
8axoneme assembly (GO:0035082)3.93709689
9cilium movement (GO:0003341)3.93173686
10motile cilium assembly (GO:0044458)3.86947732
11exogenous drug catabolic process (GO:0042738)3.82154316
12axonemal dynein complex assembly (GO:0070286)3.70267851
13cellular ketone body metabolic process (GO:0046950)3.65718628
14epithelial cilium movement (GO:0003351)3.52744049
15DNA replication checkpoint (GO:0000076)3.51758112
16tryptophan metabolic process (GO:0006568)3.48780194
17replication fork processing (GO:0031297)3.42340673
18reciprocal DNA recombination (GO:0035825)3.42296803
19reciprocal meiotic recombination (GO:0007131)3.42296803
20oxidative demethylation (GO:0070989)3.41931697
21ketone body metabolic process (GO:1902224)3.30708732
22aromatic amino acid family catabolic process (GO:0009074)3.26631687
23NAD biosynthetic process (GO:0009435)3.25675655
24cellular response to ATP (GO:0071318)3.24963492
25indolalkylamine metabolic process (GO:0006586)3.22378901
26kynurenine metabolic process (GO:0070189)3.22245841
27regulation of nuclear cell cycle DNA replication (GO:0033262)3.20059018
28flavonoid metabolic process (GO:0009812)3.15517871
29DNA strand renaturation (GO:0000733)3.15472093
30S-adenosylmethionine metabolic process (GO:0046500)3.11584004
31interkinetic nuclear migration (GO:0022027)3.06060489
32alkaloid metabolic process (GO:0009820)3.01674394
33carnitine transmembrane transport (GO:1902603)3.01330201
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00559929
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.00559929
36regulation of translation, ncRNA-mediated (GO:0045974)3.00559929
37double-strand break repair via homologous recombination (GO:0000724)2.98371237
38cornea development in camera-type eye (GO:0061303)2.97837826
39amino-acid betaine transport (GO:0015838)2.95737996
40carnitine transport (GO:0015879)2.95737996
41recombinational repair (GO:0000725)2.94779918
42fatty acid transmembrane transport (GO:1902001)2.92831988
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87132974
44centriole assembly (GO:0098534)2.86995255
45regulation of hippo signaling (GO:0035330)2.85847915
46rRNA methylation (GO:0031167)2.83289219
47quaternary ammonium group transport (GO:0015697)2.82253314
483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.82023319
49purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.82023319
50snRNA transcription (GO:0009301)2.81677504
51rRNA catabolic process (GO:0016075)2.78424301
52aromatic amino acid family metabolic process (GO:0009072)2.73502061
53iron ion import (GO:0097286)2.71345623
54transepithelial transport (GO:0070633)2.70022501
55high-density lipoprotein particle remodeling (GO:0034375)2.69729649
56nucleotide transmembrane transport (GO:1901679)2.69508852
57regulation of centriole replication (GO:0046599)2.68252486
58centriole replication (GO:0007099)2.68208074
59positive regulation of developmental pigmentation (GO:0048087)2.67702115
60benzene-containing compound metabolic process (GO:0042537)2.63166457
61monoubiquitinated protein deubiquitination (GO:0035520)2.61173268
62regulation of triglyceride biosynthetic process (GO:0010866)2.61117518
63folic acid metabolic process (GO:0046655)2.60984629
64regulation of centrosome duplication (GO:0010824)2.60682608
65positive regulation of protein kinase C signaling (GO:0090037)2.60647235
66mRNA cleavage (GO:0006379)2.58825266
67cilium organization (GO:0044782)2.58553520
68imidazole-containing compound metabolic process (GO:0052803)2.57779542
69vitamin transmembrane transport (GO:0035461)2.57229813
70cellular response to exogenous dsRNA (GO:0071360)2.56501042
71translesion synthesis (GO:0019985)2.56473082
72DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.56037218
73epoxygenase P450 pathway (GO:0019373)2.54273869
74L-fucose catabolic process (GO:0042355)2.53682153
75fucose catabolic process (GO:0019317)2.53682153
76L-fucose metabolic process (GO:0042354)2.53682153
77protein import into peroxisome matrix (GO:0016558)2.52347271
78cilium assembly (GO:0042384)2.52234682
79tRNA modification (GO:0006400)2.49817952
80cardiolipin metabolic process (GO:0032048)2.49459324
81androgen biosynthetic process (GO:0006702)2.48784472
82methionine biosynthetic process (GO:0009086)2.48532941
83pyridine nucleotide biosynthetic process (GO:0019363)2.47399017
84nicotinamide nucleotide biosynthetic process (GO:0019359)2.47399017
85biotin metabolic process (GO:0006768)2.46197517
86serine family amino acid catabolic process (GO:0009071)2.45799054
87rRNA modification (GO:0000154)2.45380230
88diterpenoid biosynthetic process (GO:0016102)2.44805724
89DNA replication initiation (GO:0006270)2.43018537
90amino-acid betaine metabolic process (GO:0006577)2.41548740
91nucleoside transmembrane transport (GO:1901642)2.40803155
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.39832887
93L-phenylalanine catabolic process (GO:0006559)2.39832887
94positive regulation of triglyceride biosynthetic process (GO:0010867)2.37976271
95regulation of histone H3-K4 methylation (GO:0051569)2.37553421
96nephron epithelium morphogenesis (GO:0072088)2.37522908
97nephron tubule morphogenesis (GO:0072078)2.37522908
98histone H3-K4 trimethylation (GO:0080182)2.36532125
99preassembly of GPI anchor in ER membrane (GO:0016254)2.36206819
100regulation of complement activation (GO:0030449)2.36030468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.85691172
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.25929084
3CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.94390507
4EGR1_23403033_ChIP-Seq_LIVER_Mouse2.87339194
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.70487736
6GATA1_22025678_ChIP-Seq_K562_Human2.68111646
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41996517
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.41994525
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40296487
10VDR_22108803_ChIP-Seq_LS180_Human2.38645959
11ZNF274_21170338_ChIP-Seq_K562_Hela2.34112174
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08125324
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06286442
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94472800
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92708014
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.91332467
17EWS_26573619_Chip-Seq_HEK293_Human1.85388574
18KDM5A_27292631_Chip-Seq_BREAST_Human1.79781998
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.77206109
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.75333015
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.72628108
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.72170644
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.70689358
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.69720031
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69107222
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.62752449
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62643228
28ER_23166858_ChIP-Seq_MCF-7_Human1.60604667
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.60469142
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59108278
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56929440
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.55394778
33FUS_26573619_Chip-Seq_HEK293_Human1.54039173
34ERA_21632823_ChIP-Seq_H3396_Human1.51951026
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49391131
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48977501
37AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.45167066
38GATA4_25053715_ChIP-Seq_YYC3_Human1.43309670
39AR_21572438_ChIP-Seq_LNCaP_Human1.43119865
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42351728
41GATA6_25053715_ChIP-Seq_YYC3_Human1.42042948
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40049948
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39656366
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.38958618
45AHR_22903824_ChIP-Seq_MCF-7_Human1.37928794
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35212752
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34832381
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32799740
49SCL_19346495_ChIP-Seq_HPC-7_Human1.29862530
50HNF4A_19822575_ChIP-Seq_HepG2_Human1.29394456
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28688079
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.28569450
53CIITA_25753668_ChIP-Seq_RAJI_Human1.28331810
54MYC_18940864_ChIP-ChIP_HL60_Human1.28151256
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.27477190
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25681836
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.21956834
58* VDR_23849224_ChIP-Seq_CD4+_Human1.19414854
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19107563
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18700432
61DCP1A_22483619_ChIP-Seq_HELA_Human1.18529234
62PHF8_20622854_ChIP-Seq_HELA_Human1.18443488
63E2F1_20622854_ChIP-Seq_HELA_Human1.18249324
64FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.18042659
65VDR_21846776_ChIP-Seq_THP-1_Human1.16016397
66HOXB7_26014856_ChIP-Seq_BT474_Human1.15506703
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15461383
68P68_20966046_ChIP-Seq_HELA_Human1.15154834
69AR_20517297_ChIP-Seq_VCAP_Human1.14588093
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14501078
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11420349
72DROSHA_22980978_ChIP-Seq_HELA_Human1.11176605
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10917567
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08440883
75TP53_22573176_ChIP-Seq_HFKS_Human1.08376842
76P53_21459846_ChIP-Seq_SAOS-2_Human1.08235971
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.06861722
78WDR5_24793694_ChIP-Seq_LNCAP_Human1.05187275
79OCT4_20526341_ChIP-Seq_ESCs_Human1.04266581
80* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03636763
81P300_27268052_Chip-Seq_Bcells_Human1.02103687
82FOXP3_21729870_ChIP-Seq_TREG_Human1.02074456
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00265154
84STAT3_23295773_ChIP-Seq_U87_Human1.00177863
85FOXA1_25552417_ChIP-Seq_VCAP_Human0.98578964
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98143300
87IRF1_19129219_ChIP-ChIP_H3396_Human0.97850659
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97669646
89BCOR_27268052_Chip-Seq_Bcells_Human0.95688941
90ETS1_20019798_ChIP-Seq_JURKAT_Human0.94781765
91NCOR_22424771_ChIP-Seq_293T_Human0.94047352
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92473680
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91741598
94GATA3_24758297_ChIP-Seq_MCF-7_Human0.90678048
95TCF4_23295773_ChIP-Seq_U87_Human0.90328596
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89821657
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89778208
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.89607025
99TAF15_26573619_Chip-Seq_HEK293_Human0.89390485
100CEBPB_22108803_ChIP-Seq_LS180_Human0.89386588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.92400715
2MP0008875_abnormal_xenobiotic_pharmacok3.69141018
3MP0003195_calcinosis3.28335747
4MP0003136_yellow_coat_color3.22585188
5MP0004043_abnormal_pH_regulation3.19317614
6MP0010094_abnormal_chromosome_stability2.88724594
7MP0005171_absent_coat_pigmentation2.78715107
8MP0005174_abnormal_tail_pigmentation2.69535249
9MP0000383_abnormal_hair_follicle2.58336271
10MP0005360_urolithiasis2.38846810
11MP0005365_abnormal_bile_salt2.37628726
12MP0001986_abnormal_taste_sensitivity2.35147058
13MP0005083_abnormal_biliary_tract2.30855940
14MP0008995_early_reproductive_senescence2.27976045
15MP0004147_increased_porphyrin_level2.22409319
16MP0002139_abnormal_hepatobiliary_system2.21116914
17MP0001873_stomach_inflammation1.96706467
18MP0005085_abnormal_gallbladder_physiolo1.96174582
19MP0002396_abnormal_hematopoietic_system1.85036901
20MP0005220_abnormal_exocrine_pancreas1.83669320
21MP0002876_abnormal_thyroid_physiology1.78957556
22MP0008058_abnormal_DNA_repair1.75875591
23MP0002638_abnormal_pupillary_reflex1.69987795
24MP0003693_abnormal_embryo_hatching1.69234206
25MP0005332_abnormal_amino_acid1.68594340
26MP0001764_abnormal_homeostasis1.67515263
27MP0003786_premature_aging1.67115616
28MP0003111_abnormal_nucleus_morphology1.62694146
29MP0000427_abnormal_hair_cycle1.58840353
30MP0005646_abnormal_pituitary_gland1.54839268
31MP0004381_abnormal_hair_follicle1.54484235
32MP0008961_abnormal_basal_metabolism1.53503106
33MP0004133_heterotaxia1.53211617
34MP0002938_white_spotting1.52329169
35MP0002160_abnormal_reproductive_system1.51138907
36MP0010329_abnormal_lipoprotein_level1.46798918
37MP0010678_abnormal_skin_adnexa1.46603766
38MP0001666_abnormal_nutrient_absorption1.44626297
39MP0003806_abnormal_nucleotide_metabolis1.41949463
40MP0003252_abnormal_bile_duct1.40794779
41MP0009697_abnormal_copulation1.40589399
42MP0005551_abnormal_eye_electrophysiolog1.39288125
43MP0001756_abnormal_urination1.36603035
44MP0003718_maternal_effect1.36226476
45MP0004019_abnormal_vitamin_homeostasis1.35420329
46MP0000538_abnormal_urinary_bladder1.28909536
47MP0005076_abnormal_cell_differentiation1.27675762
48MP0003943_abnormal_hepatobiliary_system1.23494791
49MP0010307_abnormal_tumor_latency1.22665367
50MP0003656_abnormal_erythrocyte_physiolo1.18633996
51MP0004782_abnormal_surfactant_physiolog1.18015540
52MP0009643_abnormal_urine_homeostasis1.17890541
53MP0005395_other_phenotype1.15188706
54MP0000371_diluted_coat_color1.11097853
55MP0002168_other_aberrant_phenotype1.09120629
56MP0000372_irregular_coat_pigmentation1.06974096
57MP0008872_abnormal_physiological_respon1.06757967
58MP0001661_extended_life_span1.04395009
59MP0000015_abnormal_ear_pigmentation1.01773865
60MP0010386_abnormal_urinary_bladder0.99336168
61MP0003077_abnormal_cell_cycle0.97553755
62MP0005408_hypopigmentation0.95256471
63MP0005636_abnormal_mineral_homeostasis0.95231451
64MP0002118_abnormal_lipid_homeostasis0.94694382
65MP0001968_abnormal_touch/_nociception0.93696297
66MP0000609_abnormal_liver_physiology0.93019089
67MP0000569_abnormal_digit_pigmentation0.92257990
68MP0002837_dystrophic_cardiac_calcinosis0.91120750
69MP0004808_abnormal_hematopoietic_stem0.91068723
70MP0002970_abnormal_white_adipose0.89744803
71MP0001765_abnormal_ion_homeostasis0.89554343
72MP0001929_abnormal_gametogenesis0.86906813
73MP0005075_abnormal_melanosome_morpholog0.86522467
74MP0000631_abnormal_neuroendocrine_gland0.86510246
75MP0002138_abnormal_hepatobiliary_system0.86441930
76MP0008007_abnormal_cellular_replicative0.85982130
77MP0005389_reproductive_system_phenotype0.84160877
78MP0005266_abnormal_metabolism0.83303275
79MP0002132_abnormal_respiratory_system0.80872191
80MP0002019_abnormal_tumor_incidence0.80302966
81MP0002009_preneoplasia0.80185711
82MP0002075_abnormal_coat/hair_pigmentati0.78531424
83MP0005310_abnormal_salivary_gland0.78191747
84MP0003698_abnormal_male_reproductive0.78025802
85MP0002210_abnormal_sex_determination0.77547044
86MP0003890_abnormal_embryonic-extraembry0.76154191
87MP0001324_abnormal_eye_pigmentation0.75952544
88MP0005647_abnormal_sex_gland0.75089979
89MP0005448_abnormal_energy_balance0.73875985
90MP0001485_abnormal_pinna_reflex0.73313963
91MP0003646_muscle_fatigue0.73153410
92MP0008877_abnormal_DNA_methylation0.72261065
93MP0009115_abnormal_fat_cell0.71586943
94MP0002095_abnormal_skin_pigmentation0.70728490
95MP0002136_abnormal_kidney_physiology0.70607409
96MP0001545_abnormal_hematopoietic_system0.69785883
97MP0005397_hematopoietic_system_phenotyp0.69785883
98MP0000653_abnormal_sex_gland0.69576080
99MP0005376_homeostasis/metabolism_phenot0.69188143
100MP0003045_fibrosis0.68677329

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.76410711
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.71681615
3Absent/shortened dynein arms (HP:0200106)3.71172119
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.71172119
5Pancreatic cysts (HP:0001737)3.55384783
6Chronic hepatic failure (HP:0100626)3.54230240
7Pancreatic fibrosis (HP:0100732)3.38670598
8Nephronophthisis (HP:0000090)3.31650557
9True hermaphroditism (HP:0010459)3.30000315
10Birth length less than 3rd percentile (HP:0003561)3.23609331
11Abnormal respiratory motile cilium morphology (HP:0005938)3.22146933
12Abnormal respiratory epithelium morphology (HP:0012253)3.22146933
13Duplicated collecting system (HP:0000081)3.12608226
14Cystic liver disease (HP:0006706)3.08742493
15Abnormality of midbrain morphology (HP:0002418)3.07915679
16Molar tooth sign on MRI (HP:0002419)3.07915679
17Tubular atrophy (HP:0000092)3.05348078
18Abnormal ciliary motility (HP:0012262)2.98344084
19Abnormality of the renal medulla (HP:0100957)2.97471425
20Decreased circulating renin level (HP:0003351)2.95334094
21Patellar aplasia (HP:0006443)2.90260577
22Abnormality of the renal collecting system (HP:0004742)2.88732800
23Abnormal biliary tract physiology (HP:0012439)2.88455428
24Bile duct proliferation (HP:0001408)2.88455428
25Hypoplasia of the pons (HP:0012110)2.86676637
26Abnormality of the pons (HP:0007361)2.80457453
27Abnormality of the nasal septum (HP:0000419)2.76999288
28Congenital stationary night blindness (HP:0007642)2.71611227
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.71246221
30Hyperventilation (HP:0002883)2.68717929
31Abnormal respiratory motile cilium physiology (HP:0012261)2.64439027
32Abnormal drinking behavior (HP:0030082)2.63681641
33Polydipsia (HP:0001959)2.63681641
34Aplasia/Hypoplasia of the patella (HP:0006498)2.63067849
35Cerebellar dysplasia (HP:0007033)2.61985489
36Attenuation of retinal blood vessels (HP:0007843)2.60235400
37Abnormality of the renal cortex (HP:0011035)2.56272287
38Congenital hepatic fibrosis (HP:0002612)2.50686927
39Genetic anticipation (HP:0003743)2.45852694
40Rhinitis (HP:0012384)2.44273109
41Clubbing of toes (HP:0100760)2.42711141
42Abnormality of DNA repair (HP:0003254)2.40995975
43Gaze-evoked nystagmus (HP:0000640)2.40295557
44Testicular atrophy (HP:0000029)2.37441333
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.36514950
46Sloping forehead (HP:0000340)2.33540016
47Abnormality of the fingertips (HP:0001211)2.31854423
48Abnormality of chromosome stability (HP:0003220)2.26110521
49Absent thumb (HP:0009777)2.21494646
50Ketosis (HP:0001946)2.21474432
51Prolonged partial thromboplastin time (HP:0003645)2.17061236
52Hypobetalipoproteinemia (HP:0003563)2.17034453
53Tubulointerstitial nephritis (HP:0001970)2.14908747
54Enlarged kidneys (HP:0000105)2.13002040
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.09820233
56Absent radius (HP:0003974)2.07727775
57Lip pit (HP:0100267)2.07090410
58Male pseudohermaphroditism (HP:0000037)2.06720578
59Abnormality of the preputium (HP:0100587)2.05297341
60Abnormality of pyrimidine metabolism (HP:0004353)2.04038478
61Abnormality of renin-angiotensin system (HP:0000847)2.01473721
62Furrowed tongue (HP:0000221)2.00671086
63Tachypnea (HP:0002789)2.00002320
64Poikiloderma (HP:0001029)1.99534591
65Bony spicule pigmentary retinopathy (HP:0007737)1.98099266
66Polyuria (HP:0000103)1.98034050
67Clumsiness (HP:0002312)1.96996934
68Hyperglycinuria (HP:0003108)1.96807149
69Abnormality of the ileum (HP:0001549)1.96783387
70Ketoacidosis (HP:0001993)1.96040933
71Intestinal fistula (HP:0100819)1.95252308
72Acute lymphatic leukemia (HP:0006721)1.93537888
73Short thumb (HP:0009778)1.93101438
74Bronchiectasis (HP:0002110)1.92899476
75Meckel diverticulum (HP:0002245)1.92717806
76Breast hypoplasia (HP:0003187)1.90614007
77Aplasia involving forearm bones (HP:0009822)1.90313077
78Absent forearm bone (HP:0003953)1.90313077
79Abnormal number of erythroid precursors (HP:0012131)1.88799783
80Large for gestational age (HP:0001520)1.87707954
81Ectopic kidney (HP:0000086)1.86029347
82Occipital encephalocele (HP:0002085)1.84971383
83Postaxial foot polydactyly (HP:0001830)1.82433810
84Squamous cell carcinoma (HP:0002860)1.82189378
85Aplasia of the musculature (HP:0100854)1.81750459
86Fair hair (HP:0002286)1.80552524
87Protruding tongue (HP:0010808)1.79885559
88Homocystinuria (HP:0002156)1.79273632
89Abnormality of homocysteine metabolism (HP:0010919)1.79273632
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78879736
91Chronic bronchitis (HP:0004469)1.76949789
92Rib fusion (HP:0000902)1.75475039
93Abnormal urine output (HP:0012590)1.70113311
94Stage 5 chronic kidney disease (HP:0003774)1.68767117
95Aplasia/Hypoplasia involving the musculature (HP:0001460)1.67593847
96Alkalosis (HP:0001948)1.66815641
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.65767890
98Medial flaring of the eyebrow (HP:0010747)1.65697460
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63695643
100Oligohydramnios (HP:0001562)1.63012825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.65470455
2ACVR1B3.51337789
3WNK43.48368423
4MAPK153.18142697
5AKT32.58231653
6BMPR1B2.44209232
7TLK12.44080029
8STK392.41660701
9CDK122.06081253
10TRPM72.02056023
11OXSR12.01144154
12PDK21.99522408
13ZAK1.98190229
14NME11.96739568
15MST1R1.88034444
16TAOK31.84896156
17BRSK21.83619034
18MAPKAPK31.73658632
19INSRR1.69347331
20NUAK11.62895518
21ADRBK21.54723827
22MKNK21.53463221
23MAP2K61.48032232
24EEF2K1.45734029
25GRK11.30165789
26MAP3K71.26795057
27ATR1.22492438
28MAPK111.22000384
29RPS6KB21.14995159
30NLK1.12191203
31CAMK1G1.11340820
32MELK1.07471083
33CAMK1D1.05235609
34CHEK21.00917520
35PBK0.98236951
36MKNK10.97808108
37PRKAA20.94760629
38TNK20.94740580
39TRIB30.94551768
40WEE10.91491625
41TGFBR10.88685058
42CDC70.87199188
43PLK40.87168476
44FGFR20.86132821
45MUSK0.85361165
46MAPKAPK50.82242940
47NEK20.80266648
48TTK0.80080631
49MST40.79433102
50PIK3CA0.77712261
51HIPK20.76383318
52TNIK0.74492047
53TEC0.74359681
54MTOR0.74072049
55PKN20.73938959
56CHUK0.73528259
57CDK40.73522020
58KIT0.68257429
59WNK30.67686770
60PRKAA10.67609854
61ATM0.66389158
62PNCK0.65443369
63ICK0.64695196
64MARK30.62627845
65FLT30.62207257
66LATS10.60061228
67MET0.59760390
68PIM20.59720183
69MAP4K20.59532742
70IKBKB0.59048350
71PLK10.57745310
72RPS6KA60.57372552
73WNK10.56140143
74CHEK10.53543070
75VRK20.51817517
76MAPK130.51016238
77EPHA20.50692713
78ADRBK10.47820781
79VRK10.47595153
80ITK0.47278162
81NEK60.46376573
82DAPK20.45761936
83CDK30.45282272
84FER0.43606253
85BRD40.42911673
86RPS6KA50.42582286
87ERBB20.40071675
88MAP2K20.38581963
89CDK10.37279883
90CDK20.35616872
91AURKB0.35192602
92FGFR30.34712219
93MAPK10.34158174
94GSK3B0.32923529
95MAPK30.31645089
96CDK70.30957206
97MAPK80.30815445
98MAPK140.30388979
99SIK20.30331767
100RPS6KC10.29004469

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.11232358
2Fanconi anemia pathway_Homo sapiens_hsa034602.85363169
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37509700
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22016584
5Chemical carcinogenesis_Homo sapiens_hsa052042.18493572
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.17528308
7Histidine metabolism_Homo sapiens_hsa003402.14182280
8One carbon pool by folate_Homo sapiens_hsa006702.12792567
9ABC transporters_Homo sapiens_hsa020102.07724392
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.06429450
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.04609365
12Lysine degradation_Homo sapiens_hsa003102.02586153
13Linoleic acid metabolism_Homo sapiens_hsa005912.00766962
14Caffeine metabolism_Homo sapiens_hsa002322.00556338
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96920675
16Non-homologous end-joining_Homo sapiens_hsa034501.96590989
17Butanoate metabolism_Homo sapiens_hsa006501.95647864
18Tryptophan metabolism_Homo sapiens_hsa003801.90983676
19Retinol metabolism_Homo sapiens_hsa008301.84665760
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.77855191
21DNA replication_Homo sapiens_hsa030301.77197563
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75649641
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74388768
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63642192
25Sulfur relay system_Homo sapiens_hsa041221.62578037
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56738425
27Fatty acid degradation_Homo sapiens_hsa000711.56532864
28Vitamin digestion and absorption_Homo sapiens_hsa049771.56224741
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55328282
30Nitrogen metabolism_Homo sapiens_hsa009101.55325794
31Selenocompound metabolism_Homo sapiens_hsa004501.55064685
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.54712754
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42362979
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40809451
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40291876
36Tyrosine metabolism_Homo sapiens_hsa003501.40123665
37RNA polymerase_Homo sapiens_hsa030201.31055999
38Peroxisome_Homo sapiens_hsa041461.29882041
39Base excision repair_Homo sapiens_hsa034101.26848099
40Phenylalanine metabolism_Homo sapiens_hsa003601.25244245
41Other glycan degradation_Homo sapiens_hsa005111.24951039
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21952670
43Complement and coagulation cascades_Homo sapiens_hsa046101.21207326
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.20886193
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.18514628
46Mismatch repair_Homo sapiens_hsa034301.17681854
47Ether lipid metabolism_Homo sapiens_hsa005651.13224063
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11176691
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11087416
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10475168
51Nucleotide excision repair_Homo sapiens_hsa034201.08762633
52Arginine biosynthesis_Homo sapiens_hsa002201.08678970
53Propanoate metabolism_Homo sapiens_hsa006401.00606925
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96638686
55Glycerolipid metabolism_Homo sapiens_hsa005610.96485049
56Ovarian steroidogenesis_Homo sapiens_hsa049130.95255626
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.92891141
58beta-Alanine metabolism_Homo sapiens_hsa004100.90585737
59Pyrimidine metabolism_Homo sapiens_hsa002400.90428782
60Arachidonic acid metabolism_Homo sapiens_hsa005900.85293233
61Fat digestion and absorption_Homo sapiens_hsa049750.82484048
62Sphingolipid metabolism_Homo sapiens_hsa006000.80715807
63Fatty acid metabolism_Homo sapiens_hsa012120.80274872
64Circadian rhythm_Homo sapiens_hsa047100.79750017
65Mineral absorption_Homo sapiens_hsa049780.77038945
66Purine metabolism_Homo sapiens_hsa002300.74014625
67Metabolic pathways_Homo sapiens_hsa011000.71328035
68Glutathione metabolism_Homo sapiens_hsa004800.68406928
69Bile secretion_Homo sapiens_hsa049760.65037141
70RNA degradation_Homo sapiens_hsa030180.62159238
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58901751
72Phototransduction_Homo sapiens_hsa047440.58860115
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.58037926
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57829688
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56919795
76RNA transport_Homo sapiens_hsa030130.56586727
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.52187185
78PPAR signaling pathway_Homo sapiens_hsa033200.51779650
79Insulin resistance_Homo sapiens_hsa049310.50502287
80Basal transcription factors_Homo sapiens_hsa030220.50439223
81Starch and sucrose metabolism_Homo sapiens_hsa005000.50011002
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49218634
83Taste transduction_Homo sapiens_hsa047420.48670128
84Fatty acid biosynthesis_Homo sapiens_hsa000610.48483335
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47674661
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46609138
87Pyruvate metabolism_Homo sapiens_hsa006200.45530152
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41735110
89Asthma_Homo sapiens_hsa053100.40711919
90Cell cycle_Homo sapiens_hsa041100.38129566
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36959570
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33087643
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32928458
94N-Glycan biosynthesis_Homo sapiens_hsa005100.31333908
95Vitamin B6 metabolism_Homo sapiens_hsa007500.31124613
96Systemic lupus erythematosus_Homo sapiens_hsa053220.28817636
97* Fructose and mannose metabolism_Homo sapiens_hsa000510.28581725
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24443524
99Huntingtons disease_Homo sapiens_hsa050160.24288151
100Lysosome_Homo sapiens_hsa041420.23404420

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »