ENOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the other is at its lowest. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.37363869
2nucleobase catabolic process (GO:0046113)5.23271846
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86345276
4synaptic vesicle exocytosis (GO:0016079)4.75891559
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.64076878
6positive regulation of synapse maturation (GO:0090129)4.47204532
7presynaptic membrane assembly (GO:0097105)4.35726687
8protein localization to synapse (GO:0035418)4.32030548
9behavioral response to nicotine (GO:0035095)4.26558920
10auditory behavior (GO:0031223)4.05775906
11cell migration in hindbrain (GO:0021535)4.05353015
12regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.03772240
13synaptic vesicle maturation (GO:0016188)3.95224165
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.92616093
15regulation of synaptic vesicle exocytosis (GO:2000300)3.92177966
16G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.91620501
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90205295
18vocalization behavior (GO:0071625)3.89091930
19response to pheromone (GO:0019236)3.86895299
20neuron cell-cell adhesion (GO:0007158)3.83485074
21negative regulation of cytosolic calcium ion concentration (GO:0051481)3.81031593
22synaptic vesicle endocytosis (GO:0048488)3.79992228
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.73811443
24glutamate secretion (GO:0014047)3.71363574
25innervation (GO:0060384)3.71042858
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.65085667
27gamma-aminobutyric acid transport (GO:0015812)3.64945616
28detection of light stimulus involved in sensory perception (GO:0050962)3.60882688
29detection of light stimulus involved in visual perception (GO:0050908)3.60882688
30response to auditory stimulus (GO:0010996)3.57325365
31synaptic transmission, glutamatergic (GO:0035249)3.57020598
32regulation of glutamate receptor signaling pathway (GO:1900449)3.55627831
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.52888316
34regulation of synaptic vesicle transport (GO:1902803)3.52229258
35glutamate receptor signaling pathway (GO:0007215)3.46785622
36regulation of synapse maturation (GO:0090128)3.46055160
37neuron-neuron synaptic transmission (GO:0007270)3.43542736
38head development (GO:0060322)3.38889510
39neuron recognition (GO:0008038)3.35361334
40mechanosensory behavior (GO:0007638)3.32716213
41layer formation in cerebral cortex (GO:0021819)3.30802953
42negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29833140
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.28880072
44startle response (GO:0001964)3.25081785
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19609212
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18418874
47sodium ion export (GO:0071436)3.17608944
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14418038
49positive regulation of dendritic spine morphogenesis (GO:0061003)3.13530330
50neurotransmitter secretion (GO:0007269)3.13161614
51protein polyglutamylation (GO:0018095)3.12150227
52regulation of synapse structural plasticity (GO:0051823)3.12041854
53retinal rod cell development (GO:0046548)3.12009593
54cellular potassium ion homeostasis (GO:0030007)3.11915071
55axonal fasciculation (GO:0007413)3.10863148
56neuronal action potential (GO:0019228)3.09066324
57negative regulation of microtubule polymerization (GO:0031115)3.06665335
58spinal cord development (GO:0021510)3.06307082
59cerebellar Purkinje cell differentiation (GO:0021702)3.04762534
60establishment of mitochondrion localization (GO:0051654)2.99023914
61striatum development (GO:0021756)2.97855325
62mitochondrion transport along microtubule (GO:0047497)2.94987726
63establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.94987726
64membrane hyperpolarization (GO:0060081)2.92799893
65cerebral cortex radially oriented cell migration (GO:0021799)2.91226425
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90743983
67membrane depolarization during action potential (GO:0086010)2.89755266
68neuromuscular synaptic transmission (GO:0007274)2.88941207
69positive regulation of amino acid transport (GO:0051957)2.88338462
70locomotory exploration behavior (GO:0035641)2.88111303
71behavioral defense response (GO:0002209)2.87673250
72behavioral fear response (GO:0001662)2.87673250
73cell communication by electrical coupling (GO:0010644)2.87514108
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85244777
75regulation of neuronal synaptic plasticity (GO:0048168)2.84284711
76regulation of action potential (GO:0098900)2.83610625
77calcium ion-dependent exocytosis (GO:0017156)2.82548482
78regulation of cilium movement (GO:0003352)2.82508959
79neurotransmitter-gated ion channel clustering (GO:0072578)2.82051453
80nonmotile primary cilium assembly (GO:0035058)2.81950710
81exploration behavior (GO:0035640)2.81363766
82dendrite morphogenesis (GO:0048813)2.80288671
83regulation of neurotransmitter secretion (GO:0046928)2.79513348
84positive regulation of action potential (GO:0045760)2.77488523
85adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.76510754
86behavioral response to ethanol (GO:0048149)2.75915716
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.75248638
88central nervous system neuron axonogenesis (GO:0021955)2.75062227
89calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74754716
90neuronal ion channel clustering (GO:0045161)2.74578102
91righting reflex (GO:0060013)2.74357394
92regulation of feeding behavior (GO:0060259)2.73136118
93adult walking behavior (GO:0007628)2.72803804
94central nervous system projection neuron axonogenesis (GO:0021952)2.70601122
95positive regulation of synaptic transmission, GABAergic (GO:0032230)2.69527695
96synapse organization (GO:0050808)2.67984705
97establishment of synaptic vesicle localization (GO:0097480)2.67774164
98synaptic vesicle transport (GO:0048489)2.67774164
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67419250
100positive regulation of meiosis (GO:0045836)2.65335134
101positive regulation of synapse assembly (GO:0051965)2.64957695
102neurotransmitter transport (GO:0006836)2.64952152
103mating behavior (GO:0007617)2.64215254
104regulation of neurotransmitter transport (GO:0051588)2.63826601
105regulation of microtubule-based movement (GO:0060632)2.63593896
106sympathetic nervous system development (GO:0048485)2.63303634
107regulation of dendritic spine morphogenesis (GO:0061001)2.63004531
108regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.62848917
109regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.62848917
110transmission of nerve impulse (GO:0019226)2.62335092
111synapse assembly (GO:0007416)2.59969836
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59660644
113positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.59596418
114cAMP catabolic process (GO:0006198)2.59480606
115organelle transport along microtubule (GO:0072384)2.59143560
116urinary tract smooth muscle contraction (GO:0014848)2.58945040
117regulation of postsynaptic membrane potential (GO:0060078)2.58425794
118limb bud formation (GO:0060174)2.58210009
119C4-dicarboxylate transport (GO:0015740)2.58114481
120establishment of vesicle localization (GO:0051650)2.57246426
121regulation of vesicle fusion (GO:0031338)2.57187598
122positive regulation of membrane potential (GO:0045838)2.55063986
123negative regulation of dendrite development (GO:2000171)2.54697299
124photoreceptor cell maintenance (GO:0045494)2.53660470
125negative regulation of neurotransmitter transport (GO:0051589)2.53618071
126fear response (GO:0042596)2.53529871
127presynaptic membrane organization (GO:0097090)2.52758898
128regulation of long-term neuronal synaptic plasticity (GO:0048169)2.52684634
129synaptic transmission (GO:0007268)2.51447950
130reflex (GO:0060004)2.50773388
131potassium ion homeostasis (GO:0055075)2.50437679
132prepulse inhibition (GO:0060134)2.50352136
133cell proliferation in forebrain (GO:0021846)2.50213741
134dendritic spine morphogenesis (GO:0060997)2.49994829
135negative regulation of neurotransmitter secretion (GO:0046929)2.49332751
136hippocampus development (GO:0021766)2.48710912
137dopamine receptor signaling pathway (GO:0007212)2.47163793
138axon cargo transport (GO:0008088)2.45643636
139peptidyl-arginine methylation (GO:0018216)2.45466456
140peptidyl-arginine N-methylation (GO:0035246)2.45466456
141histone arginine methylation (GO:0034969)2.44867912
142retinal cone cell development (GO:0046549)2.44164672
143postsynaptic membrane organization (GO:0001941)2.43717518
144action potential (GO:0001508)2.43692528
145positive regulation of meiotic cell cycle (GO:0051446)2.43659599
146regulation of synaptic transmission, GABAergic (GO:0032228)2.43622057
147response to histamine (GO:0034776)2.43617904
148retinal ganglion cell axon guidance (GO:0031290)2.43338949
149vesicle transport along microtubule (GO:0047496)2.43268976
150neuronal action potential propagation (GO:0019227)2.43105701
151heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.42951260
152regulation of meiosis I (GO:0060631)2.41871935
153axoneme assembly (GO:0035082)2.41317845
154adult behavior (GO:0030534)2.41244902
155regulation of collateral sprouting (GO:0048670)2.38768052
156membrane depolarization (GO:0051899)2.38489223
157synaptic transmission, cholinergic (GO:0007271)2.36534585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43371793
2GBX2_23144817_ChIP-Seq_PC3_Human3.70993800
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.62979436
4* REST_21632747_ChIP-Seq_MESCs_Mouse2.53595967
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.44534525
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37429094
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19553080
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18734246
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09116530
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.07239492
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.04453834
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04308564
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00882669
14JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93481566
15* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93289642
16* RARB_27405468_Chip-Seq_BRAIN_Mouse1.91644807
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90218731
18DROSHA_22980978_ChIP-Seq_HELA_Human1.85724605
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83366185
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82135129
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82135129
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80994056
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78106686
24* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.77067424
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74847377
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.72801483
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.71666370
28EWS_26573619_Chip-Seq_HEK293_Human1.71367991
29RNF2_27304074_Chip-Seq_NSC_Mouse1.67233574
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64927422
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64880303
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.64626537
33TAF15_26573619_Chip-Seq_HEK293_Human1.63112496
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61934303
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.61513352
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60884390
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60716403
38* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59539013
39FUS_26573619_Chip-Seq_HEK293_Human1.55090737
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54396283
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51307402
42* PIAS1_25552417_ChIP-Seq_VCAP_Human1.51281700
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47958429
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.45321625
45* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43387965
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42355890
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39696024
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.39461815
49* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38428800
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38372714
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35852834
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35772776
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33707633
54VDR_22108803_ChIP-Seq_LS180_Human1.31190094
55* P300_19829295_ChIP-Seq_ESCs_Human1.31097614
56IGF1R_20145208_ChIP-Seq_DFB_Human1.28742722
57* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28527750
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27369278
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26978004
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26891925
61RUNX2_22187159_ChIP-Seq_PCA_Human1.26789704
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25960485
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.22185945
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21331833
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20095719
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19915669
67* ER_23166858_ChIP-Seq_MCF-7_Human1.19788227
68TAL1_26923725_Chip-Seq_HPCs_Mouse1.19560218
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.19328608
70CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18999927
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18943931
72* STAT3_23295773_ChIP-Seq_U87_Human1.18846856
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18722497
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17864791
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17660320
76* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17489312
77* CBP_20019798_ChIP-Seq_JUKART_Human1.17489312
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16072763
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15855904
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.15185455
81* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14809410
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14772113
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.14562540
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14068730
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13572936
86AR_21572438_ChIP-Seq_LNCaP_Human1.13485187
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12889421
88ZNF274_21170338_ChIP-Seq_K562_Hela1.12226208
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10146479
90AR_19668381_ChIP-Seq_PC3_Human1.09221451
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09046385
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09046385
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06556740
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06490852
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.06109109
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04848143
97BCAT_22108803_ChIP-Seq_LS180_Human1.04673543
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.04399601
99SOX9_26525672_Chip-Seq_HEART_Mouse1.03741157
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.03422921
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03243221
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02586009
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.02464753
104* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02250257
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00861521
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00662690
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00299320
108* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00279738
109* SMAD3_21741376_ChIP-Seq_ESCs_Human0.99445933
110* AR_25329375_ChIP-Seq_VCAP_Human0.98912624
111* TCF4_23295773_ChIP-Seq_U87_Human0.98337785
112NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98329368
113* KDM2B_26808549_Chip-Seq_REH_Human0.97176500
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97146036
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95996050
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95682134
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95469879
118* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94789941
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94619087
120* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94583860
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94451945
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93081551
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92784824
124TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92530090
125TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92348286
126JUN_21703547_ChIP-Seq_K562_Human0.92336507
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91773511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.33870640
2MP0003880_abnormal_central_pattern3.61617474
3MP0003635_abnormal_synaptic_transmissio2.97136795
4MP0004270_analgesia2.93433205
5MP0003787_abnormal_imprinting2.62405882
6MP0001984_abnormal_olfaction2.52363779
7MP0002063_abnormal_learning/memory/cond2.49685371
8MP0005551_abnormal_eye_electrophysiolog2.47735908
9MP0002734_abnormal_mechanical_nocicepti2.34238015
10MP0001968_abnormal_touch/_nociception2.30320504
11MP0006072_abnormal_retinal_apoptosis2.25513094
12MP0006292_abnormal_olfactory_placode2.21700661
13MP0005423_abnormal_somatic_nervous2.18308314
14MP0002184_abnormal_innervation2.17350510
15MP0009745_abnormal_behavioral_response2.14567411
16MP0000778_abnormal_nervous_system2.04555703
17MP0002272_abnormal_nervous_system1.99372573
18MP0009046_muscle_twitch1.98205706
19MP0002064_seizures1.95834439
20MP0002572_abnormal_emotion/affect_behav1.94927008
21MP0001486_abnormal_startle_reflex1.94790511
22MP0005499_abnormal_olfactory_system1.94561644
23MP0005394_taste/olfaction_phenotype1.94561644
24MP0002735_abnormal_chemical_nociception1.88762268
25MP0000569_abnormal_digit_pigmentation1.87575213
26MP0008789_abnormal_olfactory_epithelium1.79523191
27MP0002736_abnormal_nociception_after1.77677599
28MP0006276_abnormal_autonomic_nervous1.70844165
29MP0001529_abnormal_vocalization1.69415345
30MP0002653_abnormal_ependyma_morphology1.69159551
31MP0000955_abnormal_spinal_cord1.65926439
32MP0003121_genomic_imprinting1.65743674
33MP0000049_abnormal_middle_ear1.61361272
34MP0001188_hyperpigmentation1.59745144
35MP0002067_abnormal_sensory_capabilities1.55255858
36MP0002882_abnormal_neuron_morphology1.54983166
37MP0004233_abnormal_muscle_weight1.53105416
38MP0004811_abnormal_neuron_physiology1.49850024
39MP0001502_abnormal_circadian_rhythm1.49730272
40MP0008877_abnormal_DNA_methylation1.48779181
41MP0005253_abnormal_eye_physiology1.48609698
42MP0002557_abnormal_social/conspecific_i1.43561140
43MP0002733_abnormal_thermal_nociception1.42723658
44MP0001970_abnormal_pain_threshold1.40290395
45MP0002160_abnormal_reproductive_system1.37768576
46MP0002752_abnormal_somatic_nervous1.36682471
47MP0003283_abnormal_digestive_organ1.35574443
48MP0002638_abnormal_pupillary_reflex1.33980467
49MP0004858_abnormal_nervous_system1.28444344
50MP0002822_catalepsy1.28424970
51MP0002152_abnormal_brain_morphology1.28389358
52MP0001440_abnormal_grooming_behavior1.27989616
53MP0003123_paternal_imprinting1.26792843
54MP0004885_abnormal_endolymph1.23373984
55MP0003122_maternal_imprinting1.22494454
56MP0003861_abnormal_nervous_system1.22209765
57MP0004145_abnormal_muscle_electrophysio1.22124867
58MP0003879_abnormal_hair_cell1.17303821
59MP0000631_abnormal_neuroendocrine_gland1.16284533
60MP0004924_abnormal_behavior1.15653159
61MP0005386_behavior/neurological_phenoty1.15653159
62MP0004133_heterotaxia1.12453107
63MP0005646_abnormal_pituitary_gland1.11157039
64MP0003890_abnormal_embryonic-extraembry1.10409361
65MP0002229_neurodegeneration1.09331430
66MP0005195_abnormal_posterior_eye1.09229039
67MP0002066_abnormal_motor_capabilities/c1.08399003
68MP0003119_abnormal_digestive_system1.06038571
69MP0002751_abnormal_autonomic_nervous1.04011817
70MP0001501_abnormal_sleep_pattern1.02877349
71MP0003942_abnormal_urinary_system1.01976853
72MP0008569_lethality_at_weaning1.00471215
73MP0002090_abnormal_vision0.98412142
74MP0000013_abnormal_adipose_tissue0.95610523
75MP0002837_dystrophic_cardiac_calcinosis0.95274106
76MP0005248_abnormal_Harderian_gland0.94575029
77MP0000534_abnormal_ureter_morphology0.93440895
78MP0003937_abnormal_limbs/digits/tail_de0.93323893
79MP0005645_abnormal_hypothalamus_physiol0.90897299
80MP0001963_abnormal_hearing_physiology0.88795533
81MP0002233_abnormal_nose_morphology0.88221688
82MP0002102_abnormal_ear_morphology0.87276351
83MP0003698_abnormal_male_reproductive0.87225789
84MP0002928_abnormal_bile_duct0.86969451
85MP0004142_abnormal_muscle_tone0.85899320
86MP0010386_abnormal_urinary_bladder0.84740875
87MP0000751_myopathy0.83826883
88MP0001293_anophthalmia0.82694960
89MP0002909_abnormal_adrenal_gland0.80065008
90MP0005623_abnormal_meninges_morphology0.79644181
91MP0001485_abnormal_pinna_reflex0.79362889
92MP0003329_amyloid_beta_deposits0.79255839
93MP0005389_reproductive_system_phenotype0.78052085
94MP0000026_abnormal_inner_ear0.76942867
95MP0003755_abnormal_palate_morphology0.76750250
96MP0003646_muscle_fatigue0.76389363
97MP0003718_maternal_effect0.76205700
98MP0005503_abnormal_tendon_morphology0.75736737
99MP0009250_abnormal_appendicular_skeleto0.75682192
100MP0010030_abnormal_orbit_morphology0.75133408
101MP0001986_abnormal_taste_sensitivity0.74551366
102MP0003111_abnormal_nucleus_morphology0.73646021
103MP0005367_renal/urinary_system_phenotyp0.72632448
104MP0000516_abnormal_urinary_system0.72632448
105MP0002938_white_spotting0.72429267
106MP0004085_abnormal_heartbeat0.72075476
107MP0003938_abnormal_ear_development0.71906559
108MP0000678_abnormal_parathyroid_gland0.69640603
109MP0004215_abnormal_myocardial_fiber0.68952924
110MP0001346_abnormal_lacrimal_gland0.68471406
111MP0002234_abnormal_pharynx_morphology0.67932650
112MP0002069_abnormal_eating/drinking_beha0.67539446
113MP0010094_abnormal_chromosome_stability0.67242974
114MP0001929_abnormal_gametogenesis0.67172392
115MP0001905_abnormal_dopamine_level0.66742039
116MP0004742_abnormal_vestibular_system0.65988149
117MP0005391_vision/eye_phenotype0.65904666
118MP0003137_abnormal_impulse_conducting0.65897114
119MP0008058_abnormal_DNA_repair0.65584032
120MP0002081_perinatal_lethality0.65180125
121MP0005187_abnormal_penis_morphology0.64454518

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.75523967
2Myokymia (HP:0002411)4.33077993
3Focal motor seizures (HP:0011153)4.14952880
4Morphological abnormality of the middle ear (HP:0008609)3.82515981
5Epileptic encephalopathy (HP:0200134)3.65481021
6Febrile seizures (HP:0002373)3.58958249
7Abnormality of the labia minora (HP:0012880)3.48831696
8Focal seizures (HP:0007359)3.36360905
9Progressive cerebellar ataxia (HP:0002073)3.35956525
10Abnormality of macular pigmentation (HP:0008002)3.21564887
11Hyperventilation (HP:0002883)3.15449055
12Retinal dysplasia (HP:0007973)2.98107741
13Central scotoma (HP:0000603)2.96040717
14Pachygyria (HP:0001302)2.95061474
15Abnormality of the lower motor neuron (HP:0002366)2.93288240
16Atonic seizures (HP:0010819)2.86636137
17Visual hallucinations (HP:0002367)2.83667842
18Type II lissencephaly (HP:0007260)2.82723955
19Abnormality of the astrocytes (HP:0100707)2.77983570
20Astrocytoma (HP:0009592)2.77983570
21Gait imbalance (HP:0002141)2.75869264
22Absence seizures (HP:0002121)2.75361786
23Pancreatic cysts (HP:0001737)2.73572678
24Polyphagia (HP:0002591)2.73059718
25Ependymoma (HP:0002888)2.66117817
26Chronic hepatic failure (HP:0100626)2.66019045
27Septo-optic dysplasia (HP:0100842)2.58131978
28Dialeptic seizures (HP:0011146)2.50793915
29Urinary bladder sphincter dysfunction (HP:0002839)2.50592064
30Molar tooth sign on MRI (HP:0002419)2.48646520
31Abnormality of midbrain morphology (HP:0002418)2.48646520
32Chorioretinal atrophy (HP:0000533)2.44763923
33Bony spicule pigmentary retinopathy (HP:0007737)2.44476313
34Genetic anticipation (HP:0003743)2.39770409
35Pendular nystagmus (HP:0012043)2.38574871
36Congenital primary aphakia (HP:0007707)2.36840461
37Nephronophthisis (HP:0000090)2.34894334
38Absent speech (HP:0001344)2.30676534
39Generalized tonic-clonic seizures (HP:0002069)2.30498437
40Ankle clonus (HP:0011448)2.30264998
41Medial flaring of the eyebrow (HP:0010747)2.28142631
42Epileptiform EEG discharges (HP:0011182)2.26735533
43Specific learning disability (HP:0001328)2.25625361
44Failure to thrive in infancy (HP:0001531)2.24996486
45Supranuclear gaze palsy (HP:0000605)2.23882802
46Fetal akinesia sequence (HP:0001989)2.23094306
47EEG with generalized epileptiform discharges (HP:0011198)2.22690240
48Gaze-evoked nystagmus (HP:0000640)2.20143971
49Glioma (HP:0009733)2.19442064
50Severe visual impairment (HP:0001141)2.19262590
51Amblyopia (HP:0000646)2.18354061
52Nephrogenic diabetes insipidus (HP:0009806)2.16364266
53Decreased central vision (HP:0007663)2.15509564
54Drooling (HP:0002307)2.14607795
55Excessive salivation (HP:0003781)2.14607795
56Anterior segment dysgenesis (HP:0007700)2.13100898
57Abnormality of the renal medulla (HP:0100957)2.11808088
58Papillary thyroid carcinoma (HP:0002895)2.11310244
59Abnormal respiratory epithelium morphology (HP:0012253)2.11170768
60Abnormal respiratory motile cilium morphology (HP:0005938)2.11170768
61Cutaneous finger syndactyly (HP:0010554)2.10961513
62Dysdiadochokinesis (HP:0002075)2.10485488
63Supernumerary spleens (HP:0009799)2.08924071
64Cerebellar dysplasia (HP:0007033)2.07297438
65Medulloblastoma (HP:0002885)2.06748537
66Truncal ataxia (HP:0002078)2.06095926
67Impaired vibration sensation in the lower limbs (HP:0002166)2.06023556
68Abnormality of the pubic bones (HP:0003172)2.04477445
69Postaxial hand polydactyly (HP:0001162)2.04364556
70Scotoma (HP:0000575)2.01101668
71Poor coordination (HP:0002370)2.00002598
72Hemiparesis (HP:0001269)1.99833750
73Shoulder girdle muscle weakness (HP:0003547)1.99266259
74Action tremor (HP:0002345)1.98293863
75Limb dystonia (HP:0002451)1.98150642
76Hypsarrhythmia (HP:0002521)1.96713365
77Spastic tetraplegia (HP:0002510)1.95362356
78Neoplasm of the oral cavity (HP:0100649)1.92416159
79Polymicrogyria (HP:0002126)1.92069928
80Broad alveolar ridges (HP:0000187)1.91052227
81Genital tract atresia (HP:0001827)1.90894733
82Vaginal atresia (HP:0000148)1.87892930
83Optic nerve hypoplasia (HP:0000609)1.86285053
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84686884
85Aplasia/Hypoplasia of the tongue (HP:0010295)1.84650930
86Dynein arm defect of respiratory motile cilia (HP:0012255)1.84330790
87Absent/shortened dynein arms (HP:0200106)1.84330790
88Mutism (HP:0002300)1.82745368
89Spastic gait (HP:0002064)1.82124509
90Esotropia (HP:0000565)1.82062339
91Agitation (HP:0000713)1.81254731
92Bifid tongue (HP:0010297)1.81037025
93Protruding tongue (HP:0010808)1.80480826
94Broad-based gait (HP:0002136)1.78886930
95Abnormality of the renal cortex (HP:0011035)1.78442450
96Narrow forehead (HP:0000341)1.77429078
97Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77418466
98Hypoplasia of the brainstem (HP:0002365)1.77418466
99Unsteady gait (HP:0002317)1.76979059
100Cutaneous syndactyly (HP:0012725)1.76689701
101Bicornuate uterus (HP:0000813)1.76604133
102Urinary urgency (HP:0000012)1.76032457
103Short foot (HP:0001773)1.75654240
104Insidious onset (HP:0003587)1.75205809
105Termporal pattern (HP:0011008)1.75205809
106Attenuation of retinal blood vessels (HP:0007843)1.75060019
107Amyotrophic lateral sclerosis (HP:0007354)1.74576649
108Impaired smooth pursuit (HP:0007772)1.74576602
109Sclerocornea (HP:0000647)1.73912980
110Cystic liver disease (HP:0006706)1.73110846
111Cortical dysplasia (HP:0002539)1.70774274
112Abolished electroretinogram (ERG) (HP:0000550)1.70568303
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.70502032
114Pheochromocytoma (HP:0002666)1.70446575
115Cupped ear (HP:0000378)1.70310801
116Exotropia (HP:0000577)1.70272213
117Choroideremia (HP:0001139)1.70103630
118Postaxial foot polydactyly (HP:0001830)1.69920567
119Abnormal rod and cone electroretinograms (HP:0008323)1.69684690
120Hypoplasia of the corpus callosum (HP:0002079)1.69161977
121Pancreatic fibrosis (HP:0100732)1.69022205
122Occipital encephalocele (HP:0002085)1.68310233
123Depression (HP:0000716)1.67564858
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.67103668
125Abnormality of the corticospinal tract (HP:0002492)1.65792985
126Absent septum pellucidum (HP:0001331)1.65589351
127Cerebral hypomyelination (HP:0006808)1.64172147
128Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64114945
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63391701
130Dysmetria (HP:0001310)1.62363819
131Abnormality of abdominal situs (HP:0011620)1.61920664
132Abdominal situs inversus (HP:0003363)1.61920664
133Delusions (HP:0000746)1.61764209
134Keratoconus (HP:0000563)1.59262654
135Increased corneal curvature (HP:0100692)1.59262654
136Hepatoblastoma (HP:0002884)1.58163177
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.57722158
138Hypoplasia of the fovea (HP:0007750)1.57722158
139True hermaphroditism (HP:0010459)1.57193603
140Lissencephaly (HP:0001339)1.56970343
141Hypogonadotrophic hypogonadism (HP:0000044)1.56468104
142Poor eye contact (HP:0000817)1.56305022
143Lower limb muscle weakness (HP:0007340)1.56258685
144Abnormal eating behavior (HP:0100738)1.55273519
145Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.55167783
146Oligodactyly (hands) (HP:0001180)1.53310189
147Pointed chin (HP:0000307)1.52724820
148Labial hypoplasia (HP:0000066)1.52278887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.87816737
2EPHA43.67997412
3NTRK33.30970047
4FRK3.03206605
5MAP3K93.01969735
6MAP3K42.76697455
7MAPK132.43095900
8PAK62.42209990
9MAPKAPK32.33523865
10MINK12.32764121
11MAP2K72.21625197
12NEK12.16901407
13PNCK2.11835549
14KSR11.92294818
15KSR21.81239618
16LATS21.78513842
17PRKD31.62583960
18EEF2K1.60443635
19STK381.50174416
20DAPK21.49505347
21CASK1.47588217
22DYRK21.43944639
23BCKDK1.36811907
24PHKG11.36785454
25PHKG21.36785454
26NTRK21.35337635
27ADRBK21.32387183
28DAPK11.29810848
29STK38L1.27067914
30PRPF4B1.26020350
31AKT31.25433728
32BRAF1.24244035
33GRK11.21657142
34NEK21.18772099
35WNK31.12077540
36DYRK1A1.10823848
37MAP3K61.10252325
38SGK2231.07674512
39SGK4941.07674512
40MAP2K41.07495992
41CDK51.07095873
42PLK21.06578085
43CAMK1G1.04843076
44PLK31.03913183
45MAP4K21.03322401
46PRKCG0.99546525
47NTRK10.98953193
48CDK190.98765402
49TTK0.97710535
50ERBB30.97318209
51CDK180.96879991
52ARAF0.96734458
53BMPR1B0.95969670
54UHMK10.95098867
55EPHA30.94522177
56CDK140.93845640
57CSNK1G10.93125058
58CDK150.92547891
59TRIM280.90291397
60CSNK1G20.89007096
61CAMKK10.88634452
62PRKCE0.86670962
63EPHB20.84434176
64CDK11A0.82820820
65BCR0.82504079
66CHEK20.81952123
67ERBB40.80494848
68STK390.77098372
69SGK20.75125068
70FER0.74467041
71BRSK10.73861386
72CAMK2A0.73333549
73RAF10.71971815
74MARK20.71869343
75WNK40.71537159
76RPS6KA40.71319270
77AURKA0.71176847
78PINK10.70947179
79CDK80.70498265
80PKN10.69004349
81TSSK60.65459973
82PAK30.64598131
83PRKCZ0.63444146
84PLK10.61540124
85INSRR0.61024261
86OXSR10.60537607
87BMPR20.60281501
88SIK20.60000973
89CSNK1G30.59552435
90TLK10.59406708
91RPS6KB20.58568576
92GRK50.58011092
93CDC70.57075425
94TNIK0.56916715
95MELK0.56731281
96CSNK1A1L0.55153600
97CDK30.52640942
98CAMK2G0.52449372
99SIK30.52411068
100CSNK1E0.51966806
101DYRK30.51640709
102TYRO30.51435946
103CDC42BPA0.51129671
104MAPK100.50993440
105TAF10.50856081
106FES0.50272035
107SRPK10.48397155
108LIMK10.47749587
109CAMK2B0.46653864
110RPS6KA20.46103241
111GSK3B0.44984629
112PRKAA10.44327123
113CAMKK20.43177352
114PRKACA0.43082723
115CAMK10.42030775
116CAMK2D0.41659020
117MAP3K20.41407103
118CCNB10.40835638
119CDK10.40739872
120PRKCH0.40648518
121CSNK1D0.40604755
122PASK0.39896886
123RPS6KA30.39556869
124TAOK10.38959232
125RPS6KB10.38523941
126NEK60.37831046
127TIE10.37649975
128ZAK0.37153942
129SGK10.35726431
130MAP2K10.35599415
131STK110.35582506
132MAPK90.35007872
133ADRBK10.34807132
134MAPK150.34029149
135PRKG10.33673811
136NUAK10.32940867
137CAMK40.32643632
138PRKACB0.30671015
139CSNK1A10.29840085
140CAMK1D0.29594980

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08787701
2Synaptic vesicle cycle_Homo sapiens_hsa047213.58946166
3Olfactory transduction_Homo sapiens_hsa047403.04066535
4GABAergic synapse_Homo sapiens_hsa047272.81183483
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72705683
6Morphine addiction_Homo sapiens_hsa050322.58795269
7Phototransduction_Homo sapiens_hsa047442.54887740
8Circadian entrainment_Homo sapiens_hsa047132.50303098
9Glutamatergic synapse_Homo sapiens_hsa047242.24349416
10Dopaminergic synapse_Homo sapiens_hsa047282.12617957
11Long-term potentiation_Homo sapiens_hsa047201.93231388
12Insulin secretion_Homo sapiens_hsa049111.89124124
13Amphetamine addiction_Homo sapiens_hsa050311.86142287
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83314066
15Cholinergic synapse_Homo sapiens_hsa047251.76642318
16Taste transduction_Homo sapiens_hsa047421.75208538
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69471284
18Serotonergic synapse_Homo sapiens_hsa047261.67861083
19Oocyte meiosis_Homo sapiens_hsa041141.66366300
20Salivary secretion_Homo sapiens_hsa049701.51731412
21Collecting duct acid secretion_Homo sapiens_hsa049661.51154488
22Oxytocin signaling pathway_Homo sapiens_hsa049211.44377205
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43983710
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43315409
25Long-term depression_Homo sapiens_hsa047301.41060932
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35717583
27Circadian rhythm_Homo sapiens_hsa047101.34080574
28Butanoate metabolism_Homo sapiens_hsa006501.32184985
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31366875
30Axon guidance_Homo sapiens_hsa043601.31013213
31Renin secretion_Homo sapiens_hsa049241.30666379
32Gap junction_Homo sapiens_hsa045401.22617331
33Calcium signaling pathway_Homo sapiens_hsa040201.22497739
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19306817
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17496842
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16715170
37Cocaine addiction_Homo sapiens_hsa050301.16236553
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13043548
39GnRH signaling pathway_Homo sapiens_hsa049121.11904322
40Dorso-ventral axis formation_Homo sapiens_hsa043201.10700112
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10593374
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09875312
43Cardiac muscle contraction_Homo sapiens_hsa042601.07471669
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06958363
45Alcoholism_Homo sapiens_hsa050341.05370949
46Ether lipid metabolism_Homo sapiens_hsa005651.05020260
47Colorectal cancer_Homo sapiens_hsa052101.04877017
48Gastric acid secretion_Homo sapiens_hsa049711.01619669
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01300510
50cAMP signaling pathway_Homo sapiens_hsa040240.98304371
51Steroid biosynthesis_Homo sapiens_hsa001000.97532049
52Linoleic acid metabolism_Homo sapiens_hsa005910.96929068
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96560162
54Fatty acid biosynthesis_Homo sapiens_hsa000610.92805487
55Estrogen signaling pathway_Homo sapiens_hsa049150.91536038
56Type II diabetes mellitus_Homo sapiens_hsa049300.90435431
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90016292
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87705217
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85596345
60Vibrio cholerae infection_Homo sapiens_hsa051100.84758236
61ErbB signaling pathway_Homo sapiens_hsa040120.84579761
62ABC transporters_Homo sapiens_hsa020100.81107419
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80588559
64Cell cycle_Homo sapiens_hsa041100.79774092
65mRNA surveillance pathway_Homo sapiens_hsa030150.78836196
66Sulfur relay system_Homo sapiens_hsa041220.78099033
67Glioma_Homo sapiens_hsa052140.77557485
68Endometrial cancer_Homo sapiens_hsa052130.76896307
69Melanogenesis_Homo sapiens_hsa049160.76701749
70Dilated cardiomyopathy_Homo sapiens_hsa054140.76425423
71Hippo signaling pathway_Homo sapiens_hsa043900.75814560
72mTOR signaling pathway_Homo sapiens_hsa041500.75310638
73Propanoate metabolism_Homo sapiens_hsa006400.73049880
74Hedgehog signaling pathway_Homo sapiens_hsa043400.72872583
75Selenocompound metabolism_Homo sapiens_hsa004500.72579291
76Wnt signaling pathway_Homo sapiens_hsa043100.71614913
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.70454733
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67668758
79MAPK signaling pathway_Homo sapiens_hsa040100.65564209
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64095117
81Ras signaling pathway_Homo sapiens_hsa040140.62032814
82RNA degradation_Homo sapiens_hsa030180.61532299
83Fanconi anemia pathway_Homo sapiens_hsa034600.60120397
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59921422
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59881307
86Glucagon signaling pathway_Homo sapiens_hsa049220.59824067
87Fatty acid metabolism_Homo sapiens_hsa012120.59160577
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58337900
89Choline metabolism in cancer_Homo sapiens_hsa052310.58322394
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56083661
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55549368
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55491897
93Mismatch repair_Homo sapiens_hsa034300.55380443
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55232076
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54101854
96Basal transcription factors_Homo sapiens_hsa030220.53219099
97Ovarian steroidogenesis_Homo sapiens_hsa049130.52775026
98Melanoma_Homo sapiens_hsa052180.52453065
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.51752625
100RNA transport_Homo sapiens_hsa030130.51640897
101Nitrogen metabolism_Homo sapiens_hsa009100.51311566
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.49920959
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49500487
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49407507
105Regulation of autophagy_Homo sapiens_hsa041400.49184735
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48641323
107Inositol phosphate metabolism_Homo sapiens_hsa005620.48343996
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48319657
109Thyroid hormone synthesis_Homo sapiens_hsa049180.47480113
110Peroxisome_Homo sapiens_hsa041460.46204585
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.45779677
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43729302
113Rap1 signaling pathway_Homo sapiens_hsa040150.42886638
114beta-Alanine metabolism_Homo sapiens_hsa004100.42009473
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.41711385
116Alzheimers disease_Homo sapiens_hsa050100.41698259
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41437485
118Oxidative phosphorylation_Homo sapiens_hsa001900.41424409
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40968728
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40371483
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39892768
122Purine metabolism_Homo sapiens_hsa002300.39872494
123Renal cell carcinoma_Homo sapiens_hsa052110.38627935
124Basal cell carcinoma_Homo sapiens_hsa052170.37893538
125Parkinsons disease_Homo sapiens_hsa050120.36038224
126Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35866762
127Caffeine metabolism_Homo sapiens_hsa002320.35709672
128Tight junction_Homo sapiens_hsa045300.34654689
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33913499
130Huntingtons disease_Homo sapiens_hsa050160.33395379
131Fructose and mannose metabolism_Homo sapiens_hsa000510.33055105
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.31166694
133Pancreatic secretion_Homo sapiens_hsa049720.31136629
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29810935

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