ENPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)4.72542002
2indole-containing compound catabolic process (GO:0042436)4.51642857
3indolalkylamine catabolic process (GO:0046218)4.51642857
4tryptophan catabolic process (GO:0006569)4.51642857
5aromatic amino acid family catabolic process (GO:0009074)4.33746348
6tryptophan metabolic process (GO:0006568)4.28507475
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.05582943
8L-phenylalanine catabolic process (GO:0006559)4.05582943
9protein carboxylation (GO:0018214)3.82396994
10peptidyl-glutamic acid carboxylation (GO:0017187)3.82396994
11keratan sulfate catabolic process (GO:0042340)3.79813558
12cellular glucuronidation (GO:0052695)3.78271919
13amine catabolic process (GO:0009310)3.78001513
14cellular biogenic amine catabolic process (GO:0042402)3.78001513
15kynurenine metabolic process (GO:0070189)3.75156637
16complement activation, alternative pathway (GO:0006957)3.66666328
17peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.65987117
18L-phenylalanine metabolic process (GO:0006558)3.63694395
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.63694395
20plasma lipoprotein particle assembly (GO:0034377)3.63242503
21omega-hydroxylase P450 pathway (GO:0097267)3.62923369
22collagen fibril organization (GO:0030199)3.53610301
23water-soluble vitamin biosynthetic process (GO:0042364)3.48298160
24negative regulation of complement activation (GO:0045916)3.47352738
25glucuronate metabolic process (GO:0019585)3.45381606
26uronic acid metabolic process (GO:0006063)3.45381606
27regulation of bile acid biosynthetic process (GO:0070857)3.45171161
28plasma lipoprotein particle clearance (GO:0034381)3.41118217
29regulation of protein activation cascade (GO:2000257)3.37144956
30iron ion import (GO:0097286)3.29514031
31indolalkylamine metabolic process (GO:0006586)3.29499037
32regulation of complement activation (GO:0030449)3.26076565
33intestinal absorption (GO:0050892)3.21571155
34homocysteine metabolic process (GO:0050667)3.20366749
35import into cell (GO:0098657)3.20048440
36regulation of fibrinolysis (GO:0051917)3.15698021
37plasma lipoprotein particle organization (GO:0071827)3.13747514
38regulation of apoptotic cell clearance (GO:2000425)3.13167823
39positive regulation of extracellular matrix organization (GO:1903055)3.11851322
40glyoxylate metabolic process (GO:0046487)3.08111947
41bile acid biosynthetic process (GO:0006699)3.08082241
42heme transport (GO:0015886)3.08030113
43complement activation (GO:0006956)3.07992346
44negative regulation of coagulation (GO:0050819)3.07249825
45aromatic amino acid family metabolic process (GO:0009072)3.04891514
46epoxygenase P450 pathway (GO:0019373)3.03387434
47protein-lipid complex assembly (GO:0065005)3.03249967
48negative regulation of sterol transport (GO:0032372)3.02354181
49negative regulation of cholesterol transport (GO:0032375)3.02354181
50opsonization (GO:0008228)3.01241702
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.00942087
52complement activation, classical pathway (GO:0006958)3.00618796
53high-density lipoprotein particle remodeling (GO:0034375)2.99075039
54regulation of plasminogen activation (GO:0010755)2.97801185
55lymph vessel development (GO:0001945)2.95469986
56purine ribonucleotide transport (GO:0015868)2.92879135
57transcytosis (GO:0045056)2.89749665
58nephron tubule morphogenesis (GO:0072078)2.88919260
59nephron epithelium morphogenesis (GO:0072088)2.88919260
60protein activation cascade (GO:0072376)2.88005294
61regulation of phospholipase A2 activity (GO:0032429)2.87849367
62fibrinolysis (GO:0042730)2.87547643
63protein-lipid complex subunit organization (GO:0071825)2.84024009
64peptidyl-glutamic acid modification (GO:0018200)2.83743732
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.78817015
66reverse cholesterol transport (GO:0043691)2.77077749
67phospholipid efflux (GO:0033700)2.76472065
68exogenous drug catabolic process (GO:0042738)2.75786680
69embryonic retina morphogenesis in camera-type eye (GO:0060059)2.75431785
70bile acid metabolic process (GO:0008206)2.73053085
71nucleotide-sugar biosynthetic process (GO:0009226)2.72259254
72UDP-N-acetylglucosamine metabolic process (GO:0006047)2.72027667
73positive regulation of osteoblast proliferation (GO:0033690)2.72014129
74negative regulation of fibrinolysis (GO:0051918)2.71672653
75drug catabolic process (GO:0042737)2.71584589
76regulation of cholesterol esterification (GO:0010872)2.69406972
77benzene-containing compound metabolic process (GO:0042537)2.69393928
78positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.68593615
79cholesterol transport (GO:0030301)2.68436411
80sterol transport (GO:0015918)2.68436411
81negative regulation of lipase activity (GO:0060192)2.66400296
82COPII vesicle coating (GO:0048208)2.65980687
83drug transmembrane transport (GO:0006855)2.65430880
84L-ascorbic acid metabolic process (GO:0019852)2.63351551
85diterpenoid biosynthetic process (GO:0016102)2.63328620
86regulation of glucokinase activity (GO:0033131)2.63326032
87regulation of hexokinase activity (GO:1903299)2.63326032
88lysine metabolic process (GO:0006553)2.63193184
89lysine catabolic process (GO:0006554)2.63193184
90cholesterol homeostasis (GO:0042632)2.62934494
91tyrosine metabolic process (GO:0006570)2.62341532
92very-low-density lipoprotein particle assembly (GO:0034379)2.62234987
93positive regulation of hemostasis (GO:1900048)2.60664932
94positive regulation of blood coagulation (GO:0030194)2.60664932
95regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60364563
96dermatan sulfate biosynthetic process (GO:0030208)2.60253279
97serine family amino acid catabolic process (GO:0009071)2.60189697
98sterol homeostasis (GO:0055092)2.59237113
99mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.58650937
100nucleotide transmembrane transport (GO:1901679)2.58123654
101cholesterol efflux (GO:0033344)2.57392466
102anterior/posterior axis specification, embryo (GO:0008595)2.56966783
103limb bud formation (GO:0060174)2.56271201
104urea cycle (GO:0000050)2.56023642
105urea metabolic process (GO:0019627)2.56023642
106purine nucleotide transport (GO:0015865)2.54411613
107regulation of triglyceride catabolic process (GO:0010896)2.53307773
108glycine metabolic process (GO:0006544)2.53246576
109regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.52728475
110collagen catabolic process (GO:0030574)2.52484778
111regulation of interleukin-8 secretion (GO:2000482)2.52468521
112sulfur compound catabolic process (GO:0044273)2.51844600
113acylglycerol homeostasis (GO:0055090)2.50918655
114triglyceride homeostasis (GO:0070328)2.50918655
115collagen metabolic process (GO:0032963)2.50391843
116alpha-amino acid catabolic process (GO:1901606)2.50382740
117sulfur amino acid catabolic process (GO:0000098)2.48311872
118arginine metabolic process (GO:0006525)2.47775626
119retinal metabolic process (GO:0042574)2.47230886
120detection of molecule of bacterial origin (GO:0032490)2.46119233
121L-alpha-amino acid transmembrane transport (GO:1902475)2.45146290
122protein heterotrimerization (GO:0070208)2.44988244
123chondrocyte proliferation (GO:0035988)2.44179003
124negative regulation of protein activation cascade (GO:2000258)2.44159360
125regulation of extracellular matrix disassembly (GO:0010715)2.41621631
126negative regulation of blood coagulation (GO:0030195)2.41542898
127negative regulation of hemostasis (GO:1900047)2.41542898
128bile acid and bile salt transport (GO:0015721)2.41330777
129positive regulation of hormone metabolic process (GO:0032352)2.41185501
130organ induction (GO:0001759)2.40595343
131positive regulation of glycoprotein biosynthetic process (GO:0010560)2.40163862
132dermatan sulfate metabolic process (GO:0030205)2.39844082
133phospholipid homeostasis (GO:0055091)2.39624351
134ethanol oxidation (GO:0006069)2.39123669
135branched-chain amino acid catabolic process (GO:0009083)2.38978388
136protein-lipid complex remodeling (GO:0034368)2.38888753
137macromolecular complex remodeling (GO:0034367)2.38888753
138plasma lipoprotein particle remodeling (GO:0034369)2.38888753
139positive regulation of coagulation (GO:0050820)2.38687619
140lipoprotein metabolic process (GO:0042157)2.38360335
141polyol transport (GO:0015791)2.36681704
142negative regulation of wound healing (GO:0061045)2.36666150
143lipid homeostasis (GO:0055088)2.35805004
144acute-phase response (GO:0006953)2.34787842
145NAD biosynthetic process (GO:0009435)2.33089238
146mesenchymal cell differentiation (GO:0048762)2.32656122
147nitrogen cycle metabolic process (GO:0071941)2.32423985
148multicellular organismal catabolic process (GO:0044243)2.32117585
149blood coagulation, intrinsic pathway (GO:0007597)2.31982132
150regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.31428331
151multicellular organismal macromolecule metabolic process (GO:0044259)2.31278798
152low-density lipoprotein particle remodeling (GO:0034374)2.28818950
153mesenchymal cell differentiation involved in renal system development (GO:2001012)2.28796128
154mesenchymal cell differentiation involved in kidney development (GO:0072161)2.28796128
155skin morphogenesis (GO:0043589)2.27904593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.94368720
2EGR1_23403033_ChIP-Seq_LIVER_Mouse3.79438641
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.54041808
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.14420448
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.70753532
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.68642649
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.65183264
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32427130
9* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25284268
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.18019593
11* FOXA2_19822575_ChIP-Seq_HepG2_Human2.16324357
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15089561
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.06276122
14ZNF274_21170338_ChIP-Seq_K562_Hela1.98848011
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.96777944
16AR_21572438_ChIP-Seq_LNCaP_Human1.93354269
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.91419195
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.87629612
19* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85299230
20GBX2_23144817_ChIP-Seq_PC3_Human1.84939803
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.82698629
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77179352
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74691489
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.74262301
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72401243
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.72209647
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71363281
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69973853
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69973853
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68567033
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68029109
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67913078
33* CJUN_26792858_Chip-Seq_BT549_Human1.65946508
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65590137
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.65383669
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.63537896
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63039186
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62123341
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61758874
40* EZH2_27294783_Chip-Seq_NPCs_Mouse1.61332559
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59093218
42TP53_18474530_ChIP-ChIP_U2OS_Human1.58982400
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58681369
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58637333
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55835957
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53115623
47AR_21909140_ChIP-Seq_LNCAP_Human1.52845885
48VDR_22108803_ChIP-Seq_LS180_Human1.51471141
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.49800785
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.48783268
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.48411693
52GATA4_25053715_ChIP-Seq_YYC3_Human1.44370430
53CDX2_22108803_ChIP-Seq_LS180_Human1.43992579
54FUS_26573619_Chip-Seq_HEK293_Human1.42607912
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42308460
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40340253
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40089553
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39114308
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35938095
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.35694048
61* EED_16625203_ChIP-ChIP_MESCs_Mouse1.33583271
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33320393
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32254916
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30479977
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.30100829
66* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29522970
67EWS_26573619_Chip-Seq_HEK293_Human1.29355973
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29018300
69SOX2_20726797_ChIP-Seq_SW620_Human1.26525757
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25970976
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25820172
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25231499
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23707408
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.23647214
75TAF15_26573619_Chip-Seq_HEK293_Human1.23222243
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.21721041
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21644515
78P53_22387025_ChIP-Seq_ESCs_Mouse1.20583947
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.20284964
80SOX2_19829295_ChIP-Seq_ESCs_Human1.19981788
81NANOG_19829295_ChIP-Seq_ESCs_Human1.19981788
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19064871
83VDR_24787735_ChIP-Seq_THP-1_Human1.18068061
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17989699
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17253955
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.16581663
87HTT_18923047_ChIP-ChIP_STHdh_Human1.16504180
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.16025243
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15473306
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15242770
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15189261
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14695119
93* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14412572
94RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14354457
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14300061
96ELK1_19687146_ChIP-ChIP_HELA_Human1.14085800
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13745760
98* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13722069
99SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13512141
100BCAT_22108803_ChIP-Seq_LS180_Human1.13088363
101SMAD4_21799915_ChIP-Seq_A2780_Human1.12919640
102PU1_27457419_Chip-Seq_LIVER_Mouse1.12602995
103P300_18555785_Chip-Seq_ESCs_Mouse1.12524308
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12164019
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.12109178
106ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11254561
107NMYC_18555785_Chip-Seq_ESCs_Mouse1.11162834
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.10552771
109TCF4_22108803_ChIP-Seq_LS180_Human1.10470159
110* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10155453
111* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09862056
112ZFX_18555785_Chip-Seq_ESCs_Mouse1.07048861
113HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05655380
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05160400
115ESR2_21235772_ChIP-Seq_MCF-7_Human1.04431598
116* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03805524
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.03034018
118* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02905631
119IRF8_21731497_ChIP-ChIP_J774_Mouse1.02570924
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.02351501
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.01991903
122PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01936226
123IGF1R_20145208_ChIP-Seq_DFB_Human1.01735509
124KLF4_18555785_Chip-Seq_ESCs_Mouse1.01723916
125KDM2B_26808549_Chip-Seq_REH_Human1.01489807
126* STAT3_23295773_ChIP-Seq_U87_Human1.01264607
127* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00847871
128WT1_19549856_ChIP-ChIP_CCG9911_Human1.00597646
129GABP_17652178_ChIP-ChIP_JURKAT_Human1.00342766
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99631182
131* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99496049
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99359548
133SRF_21415370_ChIP-Seq_HL-1_Mouse0.98423251
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98157271
135* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97771842
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.97759340
137TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97025508
138RXR_22108803_ChIP-Seq_LS180_Human0.96938523
139PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96936383
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96079012
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95371253
142IRF8_27001747_Chip-Seq_BMDM_Mouse0.95335650
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95119159
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94906403
145* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94835470
146P300_19829295_ChIP-Seq_ESCs_Human0.94807800
147ER_23166858_ChIP-Seq_MCF-7_Human0.94577987
148GATA1_22025678_ChIP-Seq_K562_Human0.94006506
149CTCF_18555785_Chip-Seq_ESCs_Mouse0.93817536
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.93149371
151* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93018697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.05549867
2MP0005503_abnormal_tendon_morphology5.51811810
3MP0005275_abnormal_skin_tensile4.52493333
4MP0002139_abnormal_hepatobiliary_system3.84380837
5MP0009780_abnormal_chondrocyte_physiolo3.38107792
6MP0003122_maternal_imprinting3.26432849
7MP0005360_urolithiasis3.25851965
8MP0005085_abnormal_gallbladder_physiolo2.86396722
9MP0003252_abnormal_bile_duct2.75867437
10MP0005365_abnormal_bile_salt2.53194890
11MP0002876_abnormal_thyroid_physiology2.26821574
12MP0002060_abnormal_skin_morphology2.03764385
13MP0008875_abnormal_xenobiotic_pharmacok2.01776943
14MP0000566_synostosis1.98870665
15* MP0003195_calcinosis1.96498197
16MP0005508_abnormal_skeleton_morphology1.95782995
17MP0001958_emphysema1.95162673
18* MP0002933_joint_inflammation1.91657529
19MP0004019_abnormal_vitamin_homeostasis1.89079599
20MP0003279_aneurysm1.84119529
21MP0003123_paternal_imprinting1.76301052
22MP0009384_cardiac_valve_regurgitation1.69256166
23MP0002108_abnormal_muscle_morphology1.66001431
24MP0001542_abnormal_bone_strength1.63134243
25MP0009250_abnormal_appendicular_skeleto1.56307827
26MP0004134_abnormal_chest_morphology1.55531379
27MP0003890_abnormal_embryonic-extraembry1.51253903
28MP0003724_increased_susceptibility_to1.46538329
29MP0004381_abnormal_hair_follicle1.44982677
30MP0002282_abnormal_trachea_morphology1.44041979
31MP0002249_abnormal_larynx_morphology1.40994166
32MP0000762_abnormal_tongue_morphology1.40159133
33* MP0005390_skeleton_phenotype1.39173165
34MP0005379_endocrine/exocrine_gland_phen1.37260391
35MP0003937_abnormal_limbs/digits/tail_de1.37148461
36MP0001915_intracranial_hemorrhage1.35457917
37MP0009697_abnormal_copulation1.34856529
38MP0005451_abnormal_body_composition1.33379610
39* MP0002998_abnormal_bone_remodeling1.32114475
40MP0003121_genomic_imprinting1.31492681
41MP0002254_reproductive_system_inflammat1.30908523
42MP0002009_preneoplasia1.30752577
43MP0005332_abnormal_amino_acid1.29842149
44MP0001666_abnormal_nutrient_absorption1.29585352
45* MP0000163_abnormal_cartilage_morphology1.29144025
46MP0003806_abnormal_nucleotide_metabolis1.28713957
47MP0001879_abnormal_lymphatic_vessel1.27861479
48MP0004272_abnormal_basement_membrane1.27557900
49MP0001661_extended_life_span1.25319547
50MP0010329_abnormal_lipoprotein_level1.24690185
51MP0002115_abnormal_skeleton_extremities1.22916498
52MP0005377_hearing/vestibular/ear_phenot1.21932556
53MP0003878_abnormal_ear_physiology1.21932556
54MP0009764_decreased_sensitivity_to1.21808572
55MP0001243_abnormal_dermal_layer1.21297245
56MP0003705_abnormal_hypodermis_morpholog1.20671357
57MP0002089_abnormal_postnatal_growth/wei1.20383439
58MP0000372_irregular_coat_pigmentation1.20104012
59MP0002138_abnormal_hepatobiliary_system1.16689970
60* MP0002896_abnormal_bone_mineralization1.16309905
61MP0005646_abnormal_pituitary_gland1.16018253
62MP0005171_absent_coat_pigmentation1.14598116
63MP0005670_abnormal_white_adipose1.12713177
64MP0003718_maternal_effect1.11506887
65MP0003567_abnormal_fetal_cardiomyocyte1.09499299
66MP0006054_spinal_hemorrhage1.09003038
67MP0003868_abnormal_feces_composition1.08995204
68MP0005257_abnormal_intraocular_pressure1.08441601
69MP0005220_abnormal_exocrine_pancreas1.07181676
70MP0002837_dystrophic_cardiac_calcinosis1.06865483
71MP0002098_abnormal_vibrissa_morphology1.06821761
72MP0000383_abnormal_hair_follicle1.05851049
73MP0005023_abnormal_wound_healing1.04648685
74MP0002295_abnormal_pulmonary_circulatio1.03884948
75MP0003119_abnormal_digestive_system1.02294054
76MP0003011_delayed_dark_adaptation1.01887985
77MP0000613_abnormal_salivary_gland1.01148703
78MP0003941_abnormal_skin_development1.00365637
79MP0005551_abnormal_eye_electrophysiolog0.98639578
80MP0003942_abnormal_urinary_system0.98307824
81MP0002132_abnormal_respiratory_system0.97886633
82MP0000639_abnormal_adrenal_gland0.97862600
83MP0002160_abnormal_reproductive_system0.97637902
84MP0000579_abnormal_nail_morphology0.96351816
85* MP0002113_abnormal_skeleton_development0.96147817
86* MP0001533_abnormal_skeleton_physiology0.96044955
87* MP0003795_abnormal_bone_structure0.95851153
88MP0003656_abnormal_erythrocyte_physiolo0.94969204
89MP0002102_abnormal_ear_morphology0.94727568
90MP0005367_renal/urinary_system_phenotyp0.92754712
91MP0000516_abnormal_urinary_system0.92754712
92MP0005187_abnormal_penis_morphology0.91668340
93MP0001324_abnormal_eye_pigmentation0.90357049
94MP0003943_abnormal_hepatobiliary_system0.89624882
95MP0002148_abnormal_hypersensitivity_rea0.87476872
96MP0002909_abnormal_adrenal_gland0.87408810
97MP0005387_immune_system_phenotype0.87398353
98MP0001790_abnormal_immune_system0.87398353
99MP0005248_abnormal_Harderian_gland0.87345219
100MP0000538_abnormal_urinary_bladder0.86699601
101MP0001299_abnormal_eye_distance/0.84656951
102MP0001346_abnormal_lacrimal_gland0.84062553
103* MP0002168_other_aberrant_phenotype0.83883299
104MP0002233_abnormal_nose_morphology0.82002367
105MP0002419_abnormal_innate_immunity0.81531856
106MP0010386_abnormal_urinary_bladder0.81431722
107MP0000013_abnormal_adipose_tissue0.81110415
108MP0001835_abnormal_antigen_presentation0.80513851
109MP0003950_abnormal_plasma_membrane0.78756838
110MP0004133_heterotaxia0.77893501
111MP0009840_abnormal_foam_cell0.77764270
112MP0010678_abnormal_skin_adnexa0.77145679
113* MP0000767_abnormal_smooth_muscle0.76884418
114MP0002109_abnormal_limb_morphology0.76658797
115MP0008775_abnormal_heart_ventricle0.76527637
116MP0010368_abnormal_lymphatic_system0.76442345
117MP0002136_abnormal_kidney_physiology0.76150202
118MP0003191_abnormal_cellular_cholesterol0.75958390
119MP0005084_abnormal_gallbladder_morpholo0.75043196
120MP0001756_abnormal_urination0.74816017
121MP0002938_white_spotting0.73906817
122MP0001270_distended_abdomen0.73213579
123MP0009643_abnormal_urine_homeostasis0.72683144
124MP0005408_hypopigmentation0.72049876
125MP0003136_yellow_coat_color0.70560943
126MP0008877_abnormal_DNA_methylation0.69989025
127MP0006082_CNS_inflammation0.69892352
128MP0002118_abnormal_lipid_homeostasis0.69660749
129MP0003436_decreased_susceptibility_to0.69393428
130MP0002166_altered_tumor_susceptibility0.69268583
131MP0000609_abnormal_liver_physiology0.68981258
132* MP0005395_other_phenotype0.68949924
133MP0001177_atelectasis0.68641985
134MP0003186_abnormal_redox_activity0.67999224
135MP0005165_increased_susceptibility_to0.66974527
136MP0000432_abnormal_head_morphology0.66960130
137MP0003646_muscle_fatigue0.66773154
138MP0002090_abnormal_vision0.66142239
139MP0001944_abnormal_pancreas_morphology0.65804182
140MP0009763_increased_sensitivity_to0.65736446
141MP0003385_abnormal_body_wall0.65387621
142MP0001764_abnormal_homeostasis0.65009191
143MP0001485_abnormal_pinna_reflex0.64848147
144MP0000371_diluted_coat_color0.64289230
145MP0003566_abnormal_cell_adhesion0.64054871
146MP0001286_abnormal_eye_development0.63984610
147MP0001293_anophthalmia0.63040723
148MP0005083_abnormal_biliary_tract0.62934590
149MP0002163_abnormal_gland_morphology0.62880345
150MP0003283_abnormal_digestive_organ0.61211427
151MP0005389_reproductive_system_phenotype0.60969028
152* MP0005636_abnormal_mineral_homeostasis0.60430225
153MP0002078_abnormal_glucose_homeostasis0.59832044
154MP0000598_abnormal_liver_morphology0.59455146
155MP0004885_abnormal_endolymph0.55537180
156MP0005410_abnormal_fertilization0.55097584
157MP0003953_abnormal_hormone_level0.54498737
158MP0006072_abnormal_retinal_apoptosis0.54408400
159MP0010030_abnormal_orbit_morphology0.54245054

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)5.77690455
2Neonatal short-limb short stature (HP:0008921)3.98615458
3Premature rupture of membranes (HP:0001788)3.86794955
4Prolonged partial thromboplastin time (HP:0003645)3.70129037
5Intrahepatic cholestasis (HP:0001406)3.49227742
6Joint hemorrhage (HP:0005261)3.48469244
7Epiphyseal dysplasia (HP:0002656)3.40543696
8Vitreoretinal degeneration (HP:0000655)3.38132640
9Protrusio acetabuli (HP:0003179)3.37464982
10Spontaneous abortion (HP:0005268)3.36839652
11Follicular hyperkeratosis (HP:0007502)3.36067340
12Pancreatic islet-cell hyperplasia (HP:0004510)3.32603033
13Complement deficiency (HP:0004431)3.12625467
14Xanthomatosis (HP:0000991)3.10691769
15Hypothermia (HP:0002045)3.10080875
16Abnormality of the nasal septum (HP:0000419)3.05558816
17Hypoglycemic coma (HP:0001325)3.04203501
18Abnormality of incisor morphology (HP:0011063)3.02848948
19Deep venous thrombosis (HP:0002625)2.91648650
20Soft skin (HP:0000977)2.85443893
21* Cardiovascular calcification (HP:0011915)2.81979859
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81473648
23Abnormality of monocarboxylic acid metabolism (HP:0010996)2.78175240
24Atrophic scars (HP:0001075)2.77602282
25Cupped ribs (HP:0000887)2.71435987
26Hypoplastic ischia (HP:0003175)2.70473685
27Hyperlipoproteinemia (HP:0010980)2.69789718
28Abnormal tarsal ossification (HP:0008369)2.68656290
29Broad metatarsal (HP:0001783)2.65043719
30Aortic dissection (HP:0002647)2.63893685
31Hypercholesterolemia (HP:0003124)2.60458330
32Osteomalacia (HP:0002749)2.59581227
33Mitral stenosis (HP:0001718)2.52103646
34Abnormality of the ischium (HP:0003174)2.51808771
35Conjugated hyperbilirubinemia (HP:0002908)2.46528331
36Glomerulonephritis (HP:0000099)2.46093462
37Pulmonary artery stenosis (HP:0004415)2.44043549
38Abnormality of complement system (HP:0005339)2.42306981
39* Vascular calcification (HP:0004934)2.40256618
40Abnormality of endocrine pancreas physiology (HP:0012093)2.39538328
41Abnormality of the pancreatic islet cells (HP:0006476)2.39538328
42Abnormality of methionine metabolism (HP:0010901)2.37979771
43Irregular epiphyses (HP:0010582)2.35962164
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.35023581
45Increased serum pyruvate (HP:0003542)2.33590873
46Bell-shaped thorax (HP:0001591)2.32011470
47Ectopia lentis (HP:0001083)2.30700071
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30595936
49Hypoalphalipoproteinemia (HP:0003233)2.30131754
50Hypoglycemic seizures (HP:0002173)2.26134726
51Delayed CNS myelination (HP:0002188)2.22858580
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22119541
53Arthropathy (HP:0003040)2.22057310
54Abnormal delivery (HP:0001787)2.21957121
55Abnormality of the common coagulation pathway (HP:0010990)2.21447464
56Hydroxyprolinuria (HP:0003080)2.21083507
57Abnormality of proline metabolism (HP:0010907)2.21083507
58Abnormality of glycolysis (HP:0004366)2.19267587
59Small epiphyses (HP:0010585)2.18855033
60Conical tooth (HP:0000698)2.18608976
61Abnormality of vitamin metabolism (HP:0100508)2.17929257
62Cervical subluxation (HP:0003308)2.17737849
63Abnormal foot bone ossification (HP:0010675)2.17368526
64Hyperinsulinemic hypoglycemia (HP:0000825)2.17237460
65Methylmalonic acidemia (HP:0002912)2.14111085
66* Myocardial infarction (HP:0001658)2.13729858
67Alopecia of scalp (HP:0002293)2.11256772
68Osteoarthritis (HP:0002758)2.10907952
69Fat malabsorption (HP:0002630)2.10847025
70Protuberant abdomen (HP:0001538)2.10065732
71Abnormality of the wing of the ilium (HP:0011867)2.07738739
72Broad alveolar ridges (HP:0000187)2.07080530
73Barrel-shaped chest (HP:0001552)2.06609870
74Biconcave vertebral bodies (HP:0004586)2.05870901
75Blue sclerae (HP:0000592)2.05780025
76Epidermoid cyst (HP:0200040)2.05158491
77Recurrent pneumonia (HP:0006532)2.04881240
78Fragile skin (HP:0001030)2.04647718
79Abnormality of carpal bone ossification (HP:0006257)2.04506069
80Metaphyseal irregularity (HP:0003025)2.04325687
81Hyperglycinemia (HP:0002154)2.04117926
82Acanthocytosis (HP:0001927)2.04040510
83Mesomelia (HP:0003027)2.03102823
84Prostate neoplasm (HP:0100787)2.03041158
85Menorrhagia (HP:0000132)1.99728029
86Gingival bleeding (HP:0000225)1.99058129
87Nephritis (HP:0000123)1.98803492
88Glycosuria (HP:0003076)1.97450741
89Abnormality of urine glucose concentration (HP:0011016)1.97450741
90Proximal tubulopathy (HP:0000114)1.96748628
91Mild short stature (HP:0003502)1.95659161
92Beaking of vertebral bodies (HP:0004568)1.95496215
93Hypoplasia of the iris (HP:0007676)1.94961385
94Ketoacidosis (HP:0001993)1.94792217
95* Hypophosphatemic rickets (HP:0004912)1.94678074
96* Rickets (HP:0002748)1.94649964
97Enlarged kidneys (HP:0000105)1.94483831
98Abnormality of serine family amino acid metabolism (HP:0010894)1.94180998
99Abnormality of glycine metabolism (HP:0010895)1.94180998
100Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93086300
101Renal cortical cysts (HP:0000803)1.91708801
102Systemic lupus erythematosus (HP:0002725)1.91153159
103Abnormality of dentin (HP:0010299)1.90871663
104Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89681008
105Flared iliac wings (HP:0002869)1.88275471
106Abnormality of the intrinsic pathway (HP:0010989)1.87043543
107Wormian bones (HP:0002645)1.86086065
108Abnormal hand bone ossification (HP:0010660)1.85387397
109Late onset (HP:0003584)1.85267687
110Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84729748
111Chronic hepatic failure (HP:0100626)1.83460456
112Hypolipoproteinemia (HP:0010981)1.83409885
113Abnormality of serum amino acid levels (HP:0003112)1.83245056
114Steatorrhea (HP:0002570)1.82549798
115Limited hip movement (HP:0008800)1.80884970
116Recurrent lower respiratory tract infections (HP:0002783)1.80874870
117Onycholysis (HP:0001806)1.79812893
118Abnormality of sulfur amino acid metabolism (HP:0004339)1.79261200
119Hepatoblastoma (HP:0002884)1.78315637
120Generalized aminoaciduria (HP:0002909)1.77484580
121Vertebral compression fractures (HP:0002953)1.77316820
122Disproportionate short-trunk short stature (HP:0003521)1.76365239
123Wide anterior fontanel (HP:0000260)1.74956838
124Bifid tongue (HP:0010297)1.74877312
125Increased corneal curvature (HP:0100692)1.74500140
126Keratoconus (HP:0000563)1.74500140
127Osteolytic defects of the hand bones (HP:0009699)1.74123736
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.74123736
129Skin nodule (HP:0200036)1.74107889
130Infantile muscular hypotonia (HP:0008947)1.74037593
131Megaloblastic anemia (HP:0001889)1.73793998
132Abnormality of pyrimidine metabolism (HP:0004353)1.73611568
133Delayed epiphyseal ossification (HP:0002663)1.72774495
134Femoral bowing (HP:0002980)1.71332998
135Vaginal fistula (HP:0004320)1.71247906
136Flat acetabular roof (HP:0003180)1.70490788
137Coronal craniosynostosis (HP:0004440)1.69969217
138Genu varum (HP:0002970)1.69942569
139Vacuolated lymphocytes (HP:0001922)1.69161357
140Hyperglycinuria (HP:0003108)1.68819457
141Aortic aneurysm (HP:0004942)1.67988873
142Hepatocellular carcinoma (HP:0001402)1.67176955
143Abnormal cartilage morphology (HP:0002763)1.66884299
144Ketosis (HP:0001946)1.66839999
145Abnormality of the middle phalanges of the toes (HP:0010183)1.66222997
146Platyspondyly (HP:0000926)1.66044025
147Hypoplastic pelvis (HP:0008839)1.65237241
148Stomach cancer (HP:0012126)1.65055953
149Abnormality of vitamin B metabolism (HP:0004340)1.64129861
150Adrenal hypoplasia (HP:0000835)1.63426957
151Meckel diverticulum (HP:0002245)1.63139343
152Supernumerary spleens (HP:0009799)1.63067313
153Brittle hair (HP:0002299)1.62995008
154Ovoid vertebral bodies (HP:0003300)1.62852566
155Hyperglycemia (HP:0003074)1.61414584
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59662017
157Absent epiphyses (HP:0010577)1.59662017
158Short tibia (HP:0005736)1.59243749
159Hyperphosphaturia (HP:0003109)1.59185253
160Asymmetry of the thorax (HP:0001555)1.55151405
161Pigmentary retinal degeneration (HP:0001146)1.54928731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK12.66950969
2MAP3K142.56068638
3TIE12.54278906
4DDR22.51585202
5IRAK32.47819453
6WNK32.45626310
7STK38L2.33157336
8PLK32.29040216
9BRSK22.20813316
10EPHA32.20763115
11EPHB22.17778879
12LATS12.13428898
13NUAK12.12382465
14INSRR2.06725292
15ZAK2.01962100
16TNK21.87499325
17ACVR1B1.86808416
18PIK3CG1.70848626
19TRIM281.68323269
20TGFBR21.67848879
21EPHB11.67070436
22IRAK41.64137206
23FGFR11.62232567
24MKNK21.59869752
25BUB11.58783356
26EIF2AK31.58676908
27BLK1.55862941
28PLK21.53160887
29TXK1.53009139
30FGFR41.44091256
31TAF11.43937098
32IKBKE1.43823747
33EIF2AK21.43114802
34NEK91.41418858
35IKBKB1.41118021
36PLK41.36600319
37TTK1.35690593
38IRAK11.34762290
39STK391.31931759
40EIF2AK11.30412740
41TSSK61.30228713
42NEK11.29371730
43TEC1.28886243
44CLK11.27906606
45NLK1.26978788
46JAK11.26502876
47PAK31.24389571
48TRPM71.24152710
49MAP4K21.17942335
50EPHA21.17791435
51ERN11.16085744
52CSNK1G11.16000261
53PIK3CA1.15840488
54GRK11.12716437
55TAOK31.12464647
56MUSK1.11865537
57VRK21.11624341
58NEK61.10194205
59OXSR11.09424924
60CASK1.09120482
61NME21.07527025
62MAP3K121.00978883
63PKN11.00633581
64FRK0.99262123
65CHUK0.98825938
66BCR0.97633368
67PBK0.96145978
68MST1R0.96112290
69BRSK10.95817280
70PLK10.95668674
71PHKG20.95633713
72PHKG10.95633713
73FER0.94928328
74STK30.94579467
75KIT0.94240542
76MST40.93615790
77MKNK10.93456796
78TYK20.92579416
79JAK30.91820744
80BCKDK0.90884111
81MAP3K30.89038407
82MYLK0.88524826
83IRAK20.88450624
84PRKCQ0.87014456
85ADRBK20.86531862
86WEE10.86313000
87LIMK10.85895177
88SGK20.85883004
89PRKCE0.84805819
90BMPR1B0.81666368
91MAPK70.81436118
92PTK20.81093846
93MAPK150.81056554
94STK160.80738574
95ERBB30.77950576
96CAMK1G0.77795564
97SRPK10.76891433
98SGK4940.76089521
99SGK2230.76089521
100CSNK1G30.74933882
101MAPKAPK30.74792374
102MET0.74570548
103ERBB40.74123170
104WNK40.72220250
105TBK10.69897071
106PRKCI0.69871875
107CSF1R0.69033147
108VRK10.67797755
109MAPKAPK50.64317397
110FGFR20.63612760
111MAP4K10.61770719
112CSK0.60838689
113CAMK1D0.60091075
114TNIK0.59884711
115GSK3A0.59383660
116MAPK40.57780469
117NEK20.57395936
118BMPR20.57106570
119SGK30.56706683
120LYN0.56542129
121YES10.56288767
122ABL10.56038234
123PAK20.55986139
124PIM20.55593156
125PRKCG0.55380097
126PRKAA20.55159150
127CSNK1G20.55067264
128BTK0.54918381
129STK240.54526305
130WNK10.53166032
131FLT30.52749509
132CAMK2G0.51976698
133CSNK1A1L0.51457791
134PAK40.51424036
135PRKD20.51243499
136CSNK1E0.50970143
137SIK30.49880604
138FGFR30.49160519
139ATM0.48959525
140PNCK0.48743100
141AKT30.47699780
142CSNK1D0.47659168
143CDK70.47646306
144MAP2K20.45924205
145STK380.45795427
146MAPK30.45700825
147IGF1R0.45520364
148PRKG20.44459358
149CSNK2A10.43225848
150MELK0.43083410
151PDGFRA0.41829915
152STK40.41173725
153KDR0.38724301
154ERBB20.38228079
155PRKAA10.37588834
156MAP2K10.37157742
157ADRBK10.34655967
158MAP2K60.34263378

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.20213756
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93085322
3Complement and coagulation cascades_Homo sapiens_hsa046102.64627836
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.48409636
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.45965405
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37679413
7Histidine metabolism_Homo sapiens_hsa003402.35846922
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33113119
9Staphylococcus aureus infection_Homo sapiens_hsa051502.32194222
10Tryptophan metabolism_Homo sapiens_hsa003802.30287405
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.25547134
12Chemical carcinogenesis_Homo sapiens_hsa052042.22697156
13Nitrogen metabolism_Homo sapiens_hsa009102.21129723
14Steroid biosynthesis_Homo sapiens_hsa001002.14255999
15Retinol metabolism_Homo sapiens_hsa008302.05798727
16Vitamin B6 metabolism_Homo sapiens_hsa007502.02138484
17ECM-receptor interaction_Homo sapiens_hsa045121.89452363
18beta-Alanine metabolism_Homo sapiens_hsa004101.79549328
19Peroxisome_Homo sapiens_hsa041461.76602541
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71078907
21Fatty acid elongation_Homo sapiens_hsa000621.69056179
22Vitamin digestion and absorption_Homo sapiens_hsa049771.67941506
23Caffeine metabolism_Homo sapiens_hsa002321.67635988
24Sulfur metabolism_Homo sapiens_hsa009201.65649543
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62795200
26Fatty acid degradation_Homo sapiens_hsa000711.61696084
27Arginine biosynthesis_Homo sapiens_hsa002201.50678417
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50577127
29Protein digestion and absorption_Homo sapiens_hsa049741.48858105
30Malaria_Homo sapiens_hsa051441.41822708
31ABC transporters_Homo sapiens_hsa020101.38324680
32Phenylalanine metabolism_Homo sapiens_hsa003601.37913839
33* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36923176
34PPAR signaling pathway_Homo sapiens_hsa033201.35710034
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34682652
36Pyruvate metabolism_Homo sapiens_hsa006201.33850313
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31835061
38One carbon pool by folate_Homo sapiens_hsa006701.31108477
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28270673
40Arachidonic acid metabolism_Homo sapiens_hsa005901.24553637
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.24087542
42Tyrosine metabolism_Homo sapiens_hsa003501.21199904
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.20265417
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.18892191
45Fatty acid metabolism_Homo sapiens_hsa012121.17494181
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15710756
47N-Glycan biosynthesis_Homo sapiens_hsa005101.14021568
48Arginine and proline metabolism_Homo sapiens_hsa003301.14018242
49Butanoate metabolism_Homo sapiens_hsa006501.13934362
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13779191
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12698752
52* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12658874
53* Starch and sucrose metabolism_Homo sapiens_hsa005001.10771891
54Proteasome_Homo sapiens_hsa030501.07752676
55Sphingolipid metabolism_Homo sapiens_hsa006001.06713070
56Folate biosynthesis_Homo sapiens_hsa007901.04377989
57Propanoate metabolism_Homo sapiens_hsa006401.03801625
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01741637
59Fatty acid biosynthesis_Homo sapiens_hsa000610.99373329
60Other glycan degradation_Homo sapiens_hsa005110.99125660
61Glutathione metabolism_Homo sapiens_hsa004800.97527567
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94453159
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.89856976
64Lysine degradation_Homo sapiens_hsa003100.89491512
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88658729
66Protein export_Homo sapiens_hsa030600.87152113
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85132772
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84927559
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.83624165
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82011586
71Linoleic acid metabolism_Homo sapiens_hsa005910.79857916
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79575000
73Biosynthesis of amino acids_Homo sapiens_hsa012300.75156423
74Bile secretion_Homo sapiens_hsa049760.74516282
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70081832
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67568797
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67206478
78Glycerolipid metabolism_Homo sapiens_hsa005610.67188302
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66181794
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65777854
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64842821
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59991265
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.59432636
84RNA polymerase_Homo sapiens_hsa030200.59226715
85Basal transcription factors_Homo sapiens_hsa030220.59196828
86Graft-versus-host disease_Homo sapiens_hsa053320.58871545
87Galactose metabolism_Homo sapiens_hsa000520.58357080
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58130392
89Carbon metabolism_Homo sapiens_hsa012000.57268436
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55960131
91Fat digestion and absorption_Homo sapiens_hsa049750.55675209
92Hematopoietic cell lineage_Homo sapiens_hsa046400.53311644
93Renin-angiotensin system_Homo sapiens_hsa046140.52320808
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.52115388
95TGF-beta signaling pathway_Homo sapiens_hsa043500.51773179
96Glucagon signaling pathway_Homo sapiens_hsa049220.51343723
97Selenocompound metabolism_Homo sapiens_hsa004500.50634229
98Ovarian steroidogenesis_Homo sapiens_hsa049130.48934147
99Thyroid hormone synthesis_Homo sapiens_hsa049180.48582080
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47798988
101Non-homologous end-joining_Homo sapiens_hsa034500.47587694
102Autoimmune thyroid disease_Homo sapiens_hsa053200.46416776
103Sulfur relay system_Homo sapiens_hsa041220.46107193
104Lysosome_Homo sapiens_hsa041420.45845043
105Focal adhesion_Homo sapiens_hsa045100.45167178
106Circadian rhythm_Homo sapiens_hsa047100.44755188
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43275626
108Hippo signaling pathway_Homo sapiens_hsa043900.42149713
109Primary immunodeficiency_Homo sapiens_hsa053400.41688643
110Amoebiasis_Homo sapiens_hsa051460.41542636
111Ether lipid metabolism_Homo sapiens_hsa005650.41126206
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38691850
113Rheumatoid arthritis_Homo sapiens_hsa053230.37144387
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36800580
115Basal cell carcinoma_Homo sapiens_hsa052170.36738436
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36434604
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36317053
118* Metabolic pathways_Homo sapiens_hsa011000.35753136
119Homologous recombination_Homo sapiens_hsa034400.34370504
120Prostate cancer_Homo sapiens_hsa052150.31281082
121RNA degradation_Homo sapiens_hsa030180.29200317
122Allograft rejection_Homo sapiens_hsa053300.29167137
123TNF signaling pathway_Homo sapiens_hsa046680.28815096
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28810468
125African trypanosomiasis_Homo sapiens_hsa051430.28303914
126Adherens junction_Homo sapiens_hsa045200.27339678
127Phototransduction_Homo sapiens_hsa047440.27148720
128Phagosome_Homo sapiens_hsa041450.27033924
129Pertussis_Homo sapiens_hsa051330.25392715
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23283763
131Mineral absorption_Homo sapiens_hsa049780.23119350
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23001077
133Hepatitis C_Homo sapiens_hsa051600.21803415

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