ENPP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.66309207
2myelination (GO:0042552)6.72000366
3axon ensheathment (GO:0008366)6.71074116
4ensheathment of neurons (GO:0007272)6.71074116
5long-chain fatty acid biosynthetic process (GO:0042759)5.77410091
6negative regulation of neurotransmitter secretion (GO:0046929)5.33718464
7myelin maintenance (GO:0043217)4.87495424
8negative regulation of neurotransmitter transport (GO:0051589)4.81960573
9cholesterol biosynthetic process (GO:0006695)4.64757654
10oligodendrocyte differentiation (GO:0048709)4.43677310
11apical protein localization (GO:0045176)4.13102898
12sterol biosynthetic process (GO:0016126)4.06666593
13presynaptic membrane organization (GO:0097090)4.05825288
14negative regulation of protein localization to cell surface (GO:2000009)4.05065478
15asymmetric protein localization (GO:0008105)4.03895338
16long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.03168379
17establishment of mitochondrion localization (GO:0051654)4.02472154
18astrocyte development (GO:0014002)3.98553649
19photoreceptor cell differentiation (GO:0046530)3.96923593
20eye photoreceptor cell differentiation (GO:0001754)3.96923593
21presynaptic membrane assembly (GO:0097105)3.93630474
22regulation of collateral sprouting (GO:0048670)3.92052126
23creatine metabolic process (GO:0006600)3.87868856
24L-amino acid import (GO:0043092)3.86897956
25response to methylmercury (GO:0051597)3.85685557
26insulin secretion (GO:0030073)3.84404728
27long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.74567059
28positive regulation of oligodendrocyte differentiation (GO:0048714)3.71156107
29response to redox state (GO:0051775)3.68717105
30astrocyte differentiation (GO:0048708)3.68322100
31amyloid precursor protein metabolic process (GO:0042982)3.66216950
32substantia nigra development (GO:0021762)3.65485399
33adhesion of symbiont to host cell (GO:0044650)3.59208200
34virion attachment to host cell (GO:0019062)3.59208200
35response to lipoprotein particle (GO:0055094)3.56851156
36import into cell (GO:0098657)3.55226994
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.52522529
38peptide hormone processing (GO:0016486)3.52248776
39fatty-acyl-CoA biosynthetic process (GO:0046949)3.52153150
40detection of calcium ion (GO:0005513)3.49648203
41isoprenoid biosynthetic process (GO:0008299)3.48963246
42regulation of type B pancreatic cell apoptotic process (GO:2000674)3.44848796
43peptidyl-tyrosine autophosphorylation (GO:0038083)3.42226366
44myelination in peripheral nervous system (GO:0022011)3.40425037
45peripheral nervous system axon ensheathment (GO:0032292)3.40425037
46macroautophagy (GO:0016236)3.39819389
47regulation of extracellular matrix disassembly (GO:0010715)3.39685898
48negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.34562433
49glutamate secretion (GO:0014047)3.33671567
50fatty-acyl-CoA metabolic process (GO:0035337)3.30472297
51dendritic spine morphogenesis (GO:0060997)3.29640514
52transmission of nerve impulse (GO:0019226)3.23796436
53negative regulation of cytosolic calcium ion concentration (GO:0051481)3.23655010
54protein palmitoylation (GO:0018345)3.20312853
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.19517383
56glycosylceramide metabolic process (GO:0006677)3.18927107
57adult walking behavior (GO:0007628)3.16367124
58positive regulation of action potential (GO:0045760)3.15211720
59neuron cell-cell adhesion (GO:0007158)3.14610123
60magnesium ion transport (GO:0015693)3.14037231
61very long-chain fatty acid metabolic process (GO:0000038)3.12062942
62negative regulation of hormone biosynthetic process (GO:0032353)3.08599846
63nucleotide transmembrane transport (GO:1901679)3.07616628
64negative regulation of JUN kinase activity (GO:0043508)3.06716531
65membrane tubulation (GO:0097320)3.06568784
66axon development (GO:0061564)3.00418554
67neuronal action potential propagation (GO:0019227)2.98894554
68limb bud formation (GO:0060174)2.96569212
69synaptic vesicle maturation (GO:0016188)2.96564461
70cellular ketone body metabolic process (GO:0046950)2.95702269
71negative regulation of axonogenesis (GO:0050771)2.93016550
72auditory receptor cell differentiation (GO:0042491)2.92818683
73proline transport (GO:0015824)2.92222835
74amino acid import (GO:0043090)2.91363750
75GPI anchor biosynthetic process (GO:0006506)2.90524892
76cerebral cortex radially oriented cell migration (GO:0021799)2.90423516
77nerve growth factor signaling pathway (GO:0038180)2.89613775
78leukocyte migration involved in inflammatory response (GO:0002523)2.89539857
79GPI anchor metabolic process (GO:0006505)2.89031385
80positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.86330787
81neuromuscular process controlling posture (GO:0050884)2.85802601
82inositol phosphate catabolic process (GO:0071545)2.85277633
83cellular response to epinephrine stimulus (GO:0071872)2.85188783
84regulation of lipoprotein metabolic process (GO:0050746)2.84417634
85peptide hormone secretion (GO:0030072)2.83644406
86positive regulation of neurotransmitter transport (GO:0051590)2.83584653
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83437868
88ketone body metabolic process (GO:1902224)2.82579701
89amyloid precursor protein catabolic process (GO:0042987)2.82501150
90cellular potassium ion homeostasis (GO:0030007)2.80695452
91thioester biosynthetic process (GO:0035384)2.79924649
92acyl-CoA biosynthetic process (GO:0071616)2.79924649
93peptide secretion (GO:0002790)2.77248127
94negative regulation of complement activation (GO:0045916)2.76964983
95negative regulation of hormone metabolic process (GO:0032351)2.75318340
96endocrine pancreas development (GO:0031018)2.72945486
97positive regulation of insulin secretion (GO:0032024)2.72597312
98peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.71622755
99peripheral nervous system development (GO:0007422)2.70644704
100neuronal ion channel clustering (GO:0045161)2.70358714
101epithelial cell fate commitment (GO:0072148)2.70293817
102neuron remodeling (GO:0016322)2.70025223
103adhesion of symbiont to host (GO:0044406)2.68242841
104regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.65252430
105potassium ion homeostasis (GO:0055075)2.63567908
106preassembly of GPI anchor in ER membrane (GO:0016254)2.62495342
107response to epinephrine (GO:0071871)2.62307600
108toxin metabolic process (GO:0009404)2.61649922
109regulation of neurotransmitter uptake (GO:0051580)2.61417592
110peptidyl-cysteine modification (GO:0018198)2.60611558
111alanine transport (GO:0032328)2.59707183
112positive regulation of cellular amine metabolic process (GO:0033240)2.57302062
113ear development (GO:0043583)2.56187562
114glial cell development (GO:0021782)2.54637782
115organ growth (GO:0035265)2.54626021
116phosphorylated carbohydrate dephosphorylation (GO:0046838)2.54271397
117inositol phosphate dephosphorylation (GO:0046855)2.54271397
118cerebellar granule cell differentiation (GO:0021707)2.53306422
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52374209
120protein localization to endosome (GO:0036010)2.50694643
121cerebellar Purkinje cell layer development (GO:0021680)2.49870166
122sequestering of extracellular ligand from receptor (GO:0035581)2.49494973
123positive regulation of glycolytic process (GO:0045821)2.49157631
124Golgi to endosome transport (GO:0006895)2.48861920
125iron coordination entity transport (GO:1901678)2.48536648
126membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48401318
127positive regulation of glial cell differentiation (GO:0045687)2.47492560
128negative regulation of protein activation cascade (GO:2000258)2.47095918
129phospholipid dephosphorylation (GO:0046839)2.46267551
130regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46200549
131membrane assembly (GO:0071709)2.45877682
132neurotransmitter secretion (GO:0007269)2.45490141
133negative regulation of inclusion body assembly (GO:0090084)2.45035539
134response to dietary excess (GO:0002021)2.44839899
135nitric oxide mediated signal transduction (GO:0007263)2.44490946
136cellular response to catecholamine stimulus (GO:0071870)2.43840961
137cellular response to monoamine stimulus (GO:0071868)2.43840961
138neurotransmitter catabolic process (GO:0042135)2.43353449
139regulation of catecholamine metabolic process (GO:0042069)2.42635854
140regulation of dopamine metabolic process (GO:0042053)2.42635854
141Golgi to plasma membrane protein transport (GO:0043001)2.42438714
142tonic smooth muscle contraction (GO:0014820)2.42164809
143locomotory exploration behavior (GO:0035641)2.41937012
144neural nucleus development (GO:0048857)2.41489730
145negative regulation of axon extension (GO:0030517)2.41227175
146glial cell differentiation (GO:0010001)2.41077439
147neurotransmitter uptake (GO:0001504)2.40322491
148heme transport (GO:0015886)2.39034643
149dopamine biosynthetic process (GO:0042416)2.36529648
150artery smooth muscle contraction (GO:0014824)2.36525839
151hormone secretion (GO:0046879)2.34741926
152L-serine transport (GO:0015825)2.34406967
153signal release (GO:0023061)2.34164649
154positive regulation of calcium ion import (GO:0090280)2.33702190
155response to gravity (GO:0009629)2.33512420
156type B pancreatic cell development (GO:0003323)2.32968492
157negative regulation of execution phase of apoptosis (GO:1900118)2.32677728
158regulation of beta-amyloid formation (GO:1902003)2.32533389
159positive regulation of peptide hormone secretion (GO:0090277)2.32500003
160positive regulation of macroautophagy (GO:0016239)2.32132326
161positive regulation of peptide secretion (GO:0002793)2.31567046
162regulation of insulin secretion (GO:0050796)2.31244211
163positive regulation of protein autophosphorylation (GO:0031954)2.31032032
164regulation of Rac protein signal transduction (GO:0035020)2.30789335
165regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.29909883
166vascular smooth muscle contraction (GO:0014829)2.29265912
167peptide transport (GO:0015833)2.28858173
168regulation of execution phase of apoptosis (GO:1900117)2.25125169
169L-phenylalanine catabolic process (GO:0006559)2.24717156
170erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.24717156
171phosphatidylinositol dephosphorylation (GO:0046856)2.23756901
172long-term synaptic potentiation (GO:0060291)2.21881358
173potassium ion import (GO:0010107)2.21145412
174positive regulation of neurotransmitter secretion (GO:0001956)2.19008806
175positive regulation of gluconeogenesis (GO:0045722)2.18914762
176positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.18913155
177hormone transport (GO:0009914)2.18511630
178regulation of neurotransmitter transport (GO:0051588)2.18361661
179glycosphingolipid biosynthetic process (GO:0006688)2.18334514
180regulation of glucokinase activity (GO:0033131)2.17770550
181regulation of hexokinase activity (GO:1903299)2.17770550
182nitric oxide biosynthetic process (GO:0006809)2.17548694
183chemosensory behavior (GO:0007635)2.17210063
184retinol metabolic process (GO:0042572)2.15124692
185regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.14820524
186inositol phosphate-mediated signaling (GO:0048016)2.12774074
187axon ensheathment in central nervous system (GO:0032291)10.6135074
188central nervous system myelination (GO:0022010)10.6135074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.61405139
2SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.62628616
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38141677
4EZH2_22144423_ChIP-Seq_EOC_Human2.30676732
5TAF15_26573619_Chip-Seq_HEK293_Human2.28108352
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27616762
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21053379
8OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.10153555
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02166668
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01555019
11RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97806514
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97806514
13EZH2_27304074_Chip-Seq_ESCs_Mouse1.96611497
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.91957066
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91810027
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91488950
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90818007
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89928450
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89113565
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85292207
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82127845
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.78320796
23ER_23166858_ChIP-Seq_MCF-7_Human1.77511260
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77302124
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74641257
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71270206
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70482220
28AR_21572438_ChIP-Seq_LNCaP_Human1.68353432
29DROSHA_22980978_ChIP-Seq_HELA_Human1.67248895
30VDR_22108803_ChIP-Seq_LS180_Human1.65689501
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.57676684
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56862136
33* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54231957
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.51988570
35* SMAD_19615063_ChIP-ChIP_OVARY_Human1.51242403
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50855456
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.50124582
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49610909
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.49390021
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47175681
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.47140038
42STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.44173482
43IGF1R_20145208_ChIP-Seq_DFB_Human1.41737882
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41235162
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.40583843
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35003448
47P300_19829295_ChIP-Seq_ESCs_Human1.31112043
48* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30568617
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29673678
50P53_22387025_ChIP-Seq_ESCs_Mouse1.28310578
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28141016
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.27803613
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.27584843
54FUS_26573619_Chip-Seq_HEK293_Human1.27070330
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26741319
56* AR_25329375_ChIP-Seq_VCAP_Human1.26625786
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26545078
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25081220
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25081220
60STAT3_23295773_ChIP-Seq_U87_Human1.24422005
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24032193
62REST_21632747_ChIP-Seq_MESCs_Mouse1.23779955
63BCAT_22108803_ChIP-Seq_LS180_Human1.23354374
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23211267
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22937999
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.20699453
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19974964
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.19544032
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16817258
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15617756
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15095355
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14530136
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14028059
74SOX2_18555785_Chip-Seq_ESCs_Mouse1.13841744
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13129954
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12449075
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.12135725
78* SMAD4_21799915_ChIP-Seq_A2780_Human1.11770369
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10327061
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.10011260
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09457302
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.08902182
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08687348
84CJUN_26792858_Chip-Seq_BT549_Human1.08641674
85LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08633098
86TCF4_23295773_ChIP-Seq_U87_Human1.08078676
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.05880784
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.05640794
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.05319966
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04904979
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04733047
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03567620
93TP53_18474530_ChIP-ChIP_U2OS_Human1.02119068
94KDM2B_26808549_Chip-Seq_REH_Human1.02030531
95* TAL1_26923725_Chip-Seq_HPCs_Mouse1.00842921
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.00756862
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00397042
98HTT_18923047_ChIP-ChIP_STHdh_Human1.00180412
99CDX2_22108803_ChIP-Seq_LS180_Human0.99647319
100* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99582040
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99295777
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99183421
103SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98554326
104PRDM14_20953172_ChIP-Seq_ESCs_Human0.98303304
105* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97978387
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97666008
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.97268128
108SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96955385
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96749193
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95627417
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95051169
112P300_18555785_Chip-Seq_ESCs_Mouse0.95036258
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94241342
114SOX2_21211035_ChIP-Seq_LN229_Gbm0.94050064
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93860536
116* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91778019
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90309291
118* EOMES_21245162_ChIP-Seq_HESCs_Human0.89634883
119AHR_22903824_ChIP-Seq_MCF-7_Human0.89527937
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89306445
121SOX2_19829295_ChIP-Seq_ESCs_Human0.89164636
122NANOG_19829295_ChIP-Seq_ESCs_Human0.89164636
123RNF2_27304074_Chip-Seq_NSC_Mouse0.89158204
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88972335
125RUNX2_22187159_ChIP-Seq_PCA_Human0.87917392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.33856951
2MP0003880_abnormal_central_pattern3.67240092
3MP0004270_analgesia3.35419689
4MP0003690_abnormal_glial_cell3.31016714
5MP0000013_abnormal_adipose_tissue3.28615937
6MP0003950_abnormal_plasma_membrane3.18461349
7MP0002837_dystrophic_cardiac_calcinosis2.89674904
8MP0002909_abnormal_adrenal_gland2.88695549
9MP0005379_endocrine/exocrine_gland_phen2.73840663
10MP0004885_abnormal_endolymph2.70754551
11MP0003329_amyloid_beta_deposits2.69326771
12MP0002272_abnormal_nervous_system2.52419915
13MP0005171_absent_coat_pigmentation2.40289909
14MP0004859_abnormal_synaptic_plasticity2.38499941
15MP0001905_abnormal_dopamine_level2.37862967
16MP0001529_abnormal_vocalization2.35137447
17MP0001486_abnormal_startle_reflex2.34948332
18MP0010386_abnormal_urinary_bladder2.34450891
19MP0003634_abnormal_glial_cell2.33663156
20MP0002064_seizures2.31213656
21MP0004742_abnormal_vestibular_system2.31120610
22MP0004142_abnormal_muscle_tone2.29312253
23MP0003136_yellow_coat_color2.19828698
24MP0004043_abnormal_pH_regulation2.17222968
25MP0003787_abnormal_imprinting2.05815202
26MP0001485_abnormal_pinna_reflex2.04529013
27MP0000778_abnormal_nervous_system1.98590942
28MP0003283_abnormal_digestive_organ1.97597665
29MP0001944_abnormal_pancreas_morphology1.94464010
30MP0002229_neurodegeneration1.92815744
31MP0009046_muscle_twitch1.90638106
32MP0003632_abnormal_nervous_system1.90348566
33MP0003122_maternal_imprinting1.82389733
34MP0003635_abnormal_synaptic_transmissio1.82313339
35MP0005409_darkened_coat_color1.80150352
36MP0009745_abnormal_behavioral_response1.77740525
37MP0002638_abnormal_pupillary_reflex1.75199129
38MP0005503_abnormal_tendon_morphology1.72453184
39MP0002734_abnormal_mechanical_nocicepti1.72099712
40MP0001958_emphysema1.71572078
41MP0002876_abnormal_thyroid_physiology1.69627610
42MP0001984_abnormal_olfaction1.68603812
43MP0000462_abnormal_digestive_system1.66609036
44MP0005410_abnormal_fertilization1.64119289
45MP0001756_abnormal_urination1.59164501
46MP0005423_abnormal_somatic_nervous1.58297650
47MP0004019_abnormal_vitamin_homeostasis1.49522006
48MP0000569_abnormal_digit_pigmentation1.48836283
49MP0003631_nervous_system_phenotype1.48496671
50MP0003195_calcinosis1.47445771
51MP0005551_abnormal_eye_electrophysiolog1.47325137
52MP0010329_abnormal_lipoprotein_level1.44653729
53MP0000955_abnormal_spinal_cord1.43410746
54MP0002693_abnormal_pancreas_physiology1.41747444
55MP0002572_abnormal_emotion/affect_behav1.40935439
56MP0001440_abnormal_grooming_behavior1.40790784
57MP0002254_reproductive_system_inflammat1.39782056
58MP0010678_abnormal_skin_adnexa1.38485021
59MP0000604_amyloidosis1.37332919
60MP0005451_abnormal_body_composition1.36877043
61MP0003879_abnormal_hair_cell1.36764384
62MP0001299_abnormal_eye_distance/1.36705314
63MP0004134_abnormal_chest_morphology1.36272167
64MP0003806_abnormal_nucleotide_metabolis1.35822181
65MP0002139_abnormal_hepatobiliary_system1.33951809
66MP0001661_extended_life_span1.33206586
67MP0002063_abnormal_learning/memory/cond1.32722149
68MP0003633_abnormal_nervous_system1.32514295
69MP0010234_abnormal_vibrissa_follicle1.31920725
70* MP0002882_abnormal_neuron_morphology1.29853922
71MP0002163_abnormal_gland_morphology1.29672179
72MP0009840_abnormal_foam_cell1.28220784
73MP0008569_lethality_at_weaning1.27974496
74MP0000383_abnormal_hair_follicle1.27423589
75MP0005058_abnormal_lysosome_morphology1.25703078
76MP0001346_abnormal_lacrimal_gland1.25137446
77MP0000566_synostosis1.24751668
78MP0002066_abnormal_motor_capabilities/c1.23086615
79MP0004147_increased_porphyrin_level1.21999310
80MP0002078_abnormal_glucose_homeostasis1.21016632
81MP0001963_abnormal_hearing_physiology1.20827155
82MP0002067_abnormal_sensory_capabilities1.20295396
83MP0005386_behavior/neurological_phenoty1.18961033
84MP0004924_abnormal_behavior1.18961033
85MP0003172_abnormal_lysosome_physiology1.18693396
86MP0003868_abnormal_feces_composition1.17754838
87MP0006054_spinal_hemorrhage1.17510010
88MP0005174_abnormal_tail_pigmentation1.16645846
89MP0002938_white_spotting1.16286506
90MP0004381_abnormal_hair_follicle1.12845705
91MP0001970_abnormal_pain_threshold1.11678137
92MP0000639_abnormal_adrenal_gland1.10703843
93MP0005448_abnormal_energy_balance1.09758746
94MP0005535_abnormal_body_temperature1.05662750
95MP0000747_muscle_weakness1.05414237
96MP0002971_abnormal_brown_adipose1.05116901
97MP0002752_abnormal_somatic_nervous1.04357433
98MP0003011_delayed_dark_adaptation0.98496941
99MP0001177_atelectasis0.98298220
100MP0002822_catalepsy0.98288586
101MP0005408_hypopigmentation0.96569576
102MP0003938_abnormal_ear_development0.93874335
103MP0008004_abnormal_stomach_pH0.92590444
104MP0005646_abnormal_pituitary_gland0.92560158
105MP0005195_abnormal_posterior_eye0.91590217
106MP0008877_abnormal_DNA_methylation0.90991813
107MP0005332_abnormal_amino_acid0.90828724
108MP0002295_abnormal_pulmonary_circulatio0.90690263
109MP0005167_abnormal_blood-brain_barrier0.90468069
110MP0002733_abnormal_thermal_nociception0.89841486
111MP0001851_eye_inflammation0.88195613
112MP0003045_fibrosis0.87251126
113MP0009780_abnormal_chondrocyte_physiolo0.86233948
114MP0000647_abnormal_sebaceous_gland0.85698747
115MP0005220_abnormal_exocrine_pancreas0.85355137
116MP0004215_abnormal_myocardial_fiber0.84721063
117MP0004145_abnormal_muscle_electrophysio0.83012047
118MP0000427_abnormal_hair_cycle0.82460742
119MP0002118_abnormal_lipid_homeostasis0.82384424
120MP0005375_adipose_tissue_phenotype0.82365767
121MP0003279_aneurysm0.81935774
122MP0005253_abnormal_eye_physiology0.81655635
123MP0005275_abnormal_skin_tensile0.80602649
124MP0003953_abnormal_hormone_level0.80224470
125MP0006072_abnormal_retinal_apoptosis0.79753602
126MP0005623_abnormal_meninges_morphology0.79573667
127MP0005248_abnormal_Harderian_gland0.79057197
128MP0005365_abnormal_bile_salt0.77357106
129* MP0002152_abnormal_brain_morphology0.76340642
130MP0008260_abnormal_autophagy0.75459718
131MP0008438_abnormal_cutaneous_collagen0.75290910
132MP0001542_abnormal_bone_strength0.74735827
133MP0002735_abnormal_chemical_nociception0.74159287
134MP0001502_abnormal_circadian_rhythm0.73554556
135MP0000003_abnormal_adipose_tissue0.73411961
136MP0000026_abnormal_inner_ear0.73331096
137MP0004185_abnormal_adipocyte_glucose0.72840156
138MP0002108_abnormal_muscle_morphology0.72293668
139MP0005645_abnormal_hypothalamus_physiol0.72287640
140MP0001968_abnormal_touch/_nociception0.72270995
141MP0000372_irregular_coat_pigmentation0.71092128
142MP0002090_abnormal_vision0.70546041
143MP0003937_abnormal_limbs/digits/tail_de0.70395523
144MP0000762_abnormal_tongue_morphology0.69979287
145MP0001501_abnormal_sleep_pattern0.69280564
146MP0000631_abnormal_neuroendocrine_gland0.68825415
147MP0000467_abnormal_esophagus_morphology0.68149006
148MP0002557_abnormal_social/conspecific_i0.66884540
149MP0002736_abnormal_nociception_after0.64544056
150MP0006082_CNS_inflammation0.64344421

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.60534516
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.60534516
3Neurofibrillary tangles (HP:0002185)6.21497417
4Abnormality of the corticospinal tract (HP:0002492)4.92878248
5Sensory axonal neuropathy (HP:0003390)4.75332989
6Parakeratosis (HP:0001036)4.54347878
7Cerebral inclusion bodies (HP:0100314)4.45100083
8Peripheral hypomyelination (HP:0007182)4.06292823
9Supranuclear gaze palsy (HP:0000605)3.69934007
10Hyperglycemia (HP:0003074)3.66458171
11Hypoglycemic seizures (HP:0002173)3.59834829
12Hyperinsulinemic hypoglycemia (HP:0000825)3.57842026
13Spastic gait (HP:0002064)3.55328406
14Intention tremor (HP:0002080)3.54149230
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.48115013
16Cerebral hypomyelination (HP:0006808)3.44282729
17Onion bulb formation (HP:0003383)3.42313569
18Hemiparesis (HP:0001269)3.38342333
19Large for gestational age (HP:0001520)3.37278328
20Increased CSF protein (HP:0002922)3.34951495
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.20872393
22Termporal pattern (HP:0011008)3.19097691
23Insidious onset (HP:0003587)3.19097691
24Postural tremor (HP:0002174)3.18342214
25Dysmetria (HP:0001310)3.17747832
26Alacrima (HP:0000522)3.10744667
27Intestinal atresia (HP:0011100)3.06089900
28Enlarged penis (HP:0000040)3.05736543
29Hypoglycemic coma (HP:0001325)3.03820709
30Abnormal auditory evoked potentials (HP:0006958)3.01135806
31Anteriorly placed anus (HP:0001545)2.98544194
32Scanning speech (HP:0002168)2.98498523
33Abnormality of glycolysis (HP:0004366)2.96232543
34Increased serum pyruvate (HP:0003542)2.96232543
35Double outlet right ventricle (HP:0001719)2.92999575
36Congenital malformation of the right heart (HP:0011723)2.92999575
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.92708904
38Insulin-resistant diabetes mellitus (HP:0000831)2.89899951
39Akinesia (HP:0002304)2.89827406
40Abnormality of calcium-phosphate metabolism (HP:0100530)2.85167768
41Ketoacidosis (HP:0001993)2.84710923
42Increased circulating renin level (HP:0000848)2.83082365
43Leukodystrophy (HP:0002415)2.77355958
44Retinal dysplasia (HP:0007973)2.69753794
45Buphthalmos (HP:0000557)2.69468792
46Torticollis (HP:0000473)2.68147179
47Pheochromocytoma (HP:0002666)2.64801692
48Slow saccadic eye movements (HP:0000514)2.64107274
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.63505208
50Abnormal eating behavior (HP:0100738)2.60424097
51Metabolic alkalosis (HP:0200114)2.55793694
52Myokymia (HP:0002411)2.55308726
53Premature skin wrinkling (HP:0100678)2.55282627
54Thickened helices (HP:0000391)2.55272918
55Ankle clonus (HP:0011448)2.53738140
56Urinary glycosaminoglycan excretion (HP:0003541)2.50857212
57Mucopolysacchariduria (HP:0008155)2.50857212
58Cerebral hemorrhage (HP:0001342)2.49154283
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44186453
60Abnormality of polysaccharide metabolism (HP:0011012)2.44186453
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44186453
62Congenital ichthyosiform erythroderma (HP:0007431)2.43182915
63Abnormality of vitamin metabolism (HP:0100508)2.43121022
64Hypokalemic alkalosis (HP:0001949)2.40861461
65Decreased lacrimation (HP:0000633)2.39647380
66Stridor (HP:0010307)2.39293094
67Polyphagia (HP:0002591)2.39162312
68Proximal tubulopathy (HP:0000114)2.36021619
69Hypothermia (HP:0002045)2.34463513
70Cardiovascular calcification (HP:0011915)2.34119529
71Autoamputation (HP:0001218)2.33908657
72Spastic paraparesis (HP:0002313)2.33400979
73Hypoplastic pelvis (HP:0008839)2.32909631
74Split foot (HP:0001839)2.32253039
75Epileptiform EEG discharges (HP:0011182)2.31803752
76Focal dystonia (HP:0004373)2.31565733
77Congenital sensorineural hearing impairment (HP:0008527)2.30806257
78Hypomagnesemia (HP:0002917)2.29382109
79Abnormality of vitamin B metabolism (HP:0004340)2.29131681
80Clumsiness (HP:0002312)2.28424743
81EEG with generalized epileptiform discharges (HP:0011198)2.27848491
82Neuroendocrine neoplasm (HP:0100634)2.26599211
83Hyperphosphatemia (HP:0002905)2.26422248
84Absent septum pellucidum (HP:0001331)2.25504649
85Vascular calcification (HP:0004934)2.25459727
86Symptomatic seizures (HP:0011145)2.22535423
87Aqueductal stenosis (HP:0002410)2.21544700
88Metaphyseal dysplasia (HP:0100255)2.19914443
89Hypokinesia (HP:0002375)2.19506114
90CNS hypomyelination (HP:0003429)2.19492369
91Methylmalonic acidemia (HP:0002912)2.19296277
92Aplasia of the phalanges of the hand (HP:0009802)2.18506908
93Aplasia involving bones of the extremities (HP:0009825)2.18506908
94Aplasia involving bones of the upper limbs (HP:0009823)2.18506908
95Megalencephaly (HP:0001355)2.12260512
96Abnormality of dentin (HP:0010299)2.11208104
97Lower limb muscle weakness (HP:0007340)2.11149253
98Nuclear cataract (HP:0100018)2.10978244
99Craniofacial dystonia (HP:0012179)2.07602838
100Hepatosplenomegaly (HP:0001433)2.07404060
101Heterochromia iridis (HP:0001100)2.07156455
102Agitation (HP:0000713)2.07099422
103Synostosis involving the elbow (HP:0003938)2.06515314
104Humeroradial synostosis (HP:0003041)2.06515314
105Anxiety (HP:0000739)2.03423992
106Febrile seizures (HP:0002373)2.03032063
107Abnormality of the pancreatic islet cells (HP:0006476)2.02834113
108Abnormality of endocrine pancreas physiology (HP:0012093)2.02834113
109Broad metatarsal (HP:0001783)2.02509629
110Action tremor (HP:0002345)2.02341438
111Coronal craniosynostosis (HP:0004440)2.01963776
112Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01718769
113Mitral stenosis (HP:0001718)1.99802536
114Infantile muscular hypotonia (HP:0008947)1.99051028
115White forelock (HP:0002211)1.98490943
116Testicular neoplasm (HP:0010788)1.97215607
117Urinary incontinence (HP:0000020)1.96547513
118Patchy hypopigmentation of hair (HP:0011365)1.96442269
119Cupped ear (HP:0000378)1.94971602
120Protrusio acetabuli (HP:0003179)1.93721505
121Hypsarrhythmia (HP:0002521)1.93402501
122Gaze-evoked nystagmus (HP:0000640)1.93392657
123Segmental peripheral demyelination/remyelination (HP:0003481)1.93216029
124Skin nodule (HP:0200036)1.92666002
125Blue irides (HP:0000635)1.92344652
126Focal seizures (HP:0007359)1.91075599
127Progressive neurologic deterioration (HP:0002344)1.90324072
128Congenital glaucoma (HP:0001087)1.90305306
129Follicular hyperkeratosis (HP:0007502)1.89758853
130Polydipsia (HP:0001959)1.89330301
131Abnormal drinking behavior (HP:0030082)1.89330301
132Partial agenesis of the corpus callosum (HP:0001338)1.88124702
133Dysostosis multiplex (HP:0000943)1.87938454
134Spastic tetraparesis (HP:0001285)1.87716340
135Limb dystonia (HP:0002451)1.87460853
136Zonular cataract (HP:0010920)1.87242694
137Focal motor seizures (HP:0011153)1.86795881
138Morphological abnormality of the inner ear (HP:0011390)1.86584633
139Bone cyst (HP:0012062)1.86104236
140Renal Fanconi syndrome (HP:0001994)1.85033505
141Hypoventilation (HP:0002791)1.84947058
142Fetal akinesia sequence (HP:0001989)1.84809966
143Hematochezia (HP:0002573)1.84474960
144Clonus (HP:0002169)1.84074384
145Abnormality of the septum pellucidum (HP:0007375)1.83838324
146Absence seizures (HP:0002121)1.82654351
147Dialeptic seizures (HP:0011146)1.82336426
148Hyperventilation (HP:0002883)1.82030145
149Partial duplication of thumb phalanx (HP:0009944)1.81572266
150Tongue fasciculations (HP:0001308)1.80778699
151Poor speech (HP:0002465)1.80470591
152Barrel-shaped chest (HP:0001552)1.79808413
153Abnormality of the middle phalanges of the toes (HP:0010183)1.77819689
154Adrenal hypoplasia (HP:0000835)1.77230483
155Vaginal atresia (HP:0000148)1.76713803
156Bowel incontinence (HP:0002607)1.75939391
157Hypoplasia of the iris (HP:0007676)1.75551480
158Generalized myoclonic seizures (HP:0002123)1.75532350
159Medial flaring of the eyebrow (HP:0010747)1.75312626
160Epileptic encephalopathy (HP:0200134)1.74992498
161Axonal loss (HP:0003447)1.74576049
162Atonic seizures (HP:0010819)1.74547292
163Abnormality of renal resorption (HP:0011038)1.73506731
164Hyperlipoproteinemia (HP:0010980)1.72713362
165Morphological abnormality of the pyramidal tract (HP:0002062)1.71871845
166Muscle fiber splitting (HP:0003555)1.71068050
167Abnormality of proline metabolism (HP:0010907)1.69969907
168Hydroxyprolinuria (HP:0003080)1.69969907
169Hypophosphatemic rickets (HP:0004912)1.69950069
170Macroorchidism (HP:0000053)1.69193465
171Prolonged QT interval (HP:0001657)1.68585052
172Decreased motor nerve conduction velocity (HP:0003431)1.68382659
173Paraparesis (HP:0002385)1.68374164
174Late onset (HP:0003584)1.68270087
175Hamartoma of the eye (HP:0010568)1.68181946
176Diminished movement (HP:0002374)1.67691740
177Neuronal loss in central nervous system (HP:0002529)1.67514546
178Relative macrocephaly (HP:0004482)1.64024355
179Genital tract atresia (HP:0001827)1.63943434
180Abnormality of magnesium homeostasis (HP:0004921)1.62604122
181Widely spaced teeth (HP:0000687)1.60994271
182Abnormality of the vitreous humor (HP:0004327)1.60984905
183Esophageal atresia (HP:0002032)1.60940076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.69174707
2FRK5.35687965
3OXSR14.68562378
4WNK43.26774970
5EPHB13.23859486
6DAPK22.69324462
7BCR2.60580290
8PRPF4B2.50793074
9TNIK2.35668161
10WNK12.35559516
11CDK192.29511290
12FGFR22.27805501
13PKN12.25553081
14MAPKAPK52.23940958
15MET2.20692379
16PBK2.09480802
17PINK11.80732844
18NEK61.77283779
19PNCK1.73976939
20UHMK11.73480233
21LIMK11.72706626
22FGFR31.70990296
23MAP4K21.70882088
24CSNK1G31.68216791
25ICK1.65962533
26AKT31.64945214
27CSNK1A1L1.64097226
28MAPK151.61739912
29NTRK11.58005976
30PAK61.43525097
31PRKD31.43042371
32EPHA41.41746777
33CAMK2B1.38982601
34EPHA31.35211624
35CSNK1G11.34423471
36MST41.32755255
37FER1.32446841
38ROCK21.32075727
39CLK11.30338434
40CSNK1G21.27639409
41NLK1.23043999
42FGR1.20839108
43CASK1.19776927
44SGK4941.17659052
45SGK2231.17659052
46CAMK2D1.17265742
47MAP3K91.16813939
48MYLK1.14917094
49MAP2K61.14431182
50TESK21.12986495
51PRKCG1.10336255
52PLK21.08268077
53CAMKK21.06485027
54STK30.95516851
55MAP3K40.93708099
56TYRO30.90485505
57PAK30.90480124
58MARK10.90129154
59PRKCQ0.88930897
60CAMK2G0.87419732
61CDK50.86652187
62SGK20.84473539
63PTK20.82537809
64CAMK2A0.80784069
65CDK140.78178231
66RIPK10.75398592
67BMPR1B0.75198247
68MARK20.72981316
69CAMK10.70529905
70MAP3K120.70214314
71PDPK10.69145526
72STK380.68870006
73TIE10.68770034
74CDK150.68303897
75PRKCE0.67170830
76ERBB40.66110542
77ROCK10.66102548
78CDC42BPA0.66021722
79LATS10.65447341
80DYRK20.64731055
81PRKD20.64002970
82CDK180.63309127
83IRAK20.63178223
84JAK10.63136275
85PRKD10.62734607
86ERBB30.62358800
87PRKCH0.61547429
88SGK30.60558927
89CDK11A0.60450528
90YES10.60286128
91PDGFRA0.59762659
92MINK10.57099552
93STK38L0.56639521
94MUSK0.56398231
95PHKG10.55945218
96PHKG20.55945218
97TESK10.55627253
98CAMK1G0.55048095
99WNK30.54519022
100ARAF0.52026701
101FYN0.51577387
102INSRR0.50258617
103PRKG10.49178068
104ACVR1B0.48564290
105CSNK1A10.48206978
106PRKAA20.48169480
107PRKAA10.47465483
108NTRK20.47378930
109GSK3A0.45332599
110STK110.44537490
111CSNK1D0.43216753
112EIF2AK30.42896655
113PRKCZ0.42098976
114RPS6KA50.39769831
115MAP3K20.39363020
116KSR20.39338079
117GRK70.39077008
118IRAK10.38859391
119FGFR40.38805683
120MAP3K130.38333288
121GRK10.38023570
122NTRK30.37741203
123PRKACB0.37526165
124PIK3CA0.37185039
125TRPM70.36258337
126ITK0.36252343
127PDK10.36051369
128MELK0.34660510
129ADRBK20.32630034
130INSR0.32332180
131MAPK130.31868408
132MAPK70.31647148
133MAP2K20.31460957
134PDGFRB0.30718095
135DDR20.30545653
136PRKACA0.30208734
137FES0.29917849
138PTK2B0.27536282
139BMPR20.27163355
140HIPK20.26098638
141MAPK100.25445874
142SGK10.24604624
143GRK50.24262710

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.99693926
2Fatty acid elongation_Homo sapiens_hsa000624.39833880
3Steroid biosynthesis_Homo sapiens_hsa001004.29951215
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.44340950
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.77841282
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65029774
7* Ether lipid metabolism_Homo sapiens_hsa005652.28942338
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.26965223
9Sulfur metabolism_Homo sapiens_hsa009202.09019950
10Protein export_Homo sapiens_hsa030602.03499934
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93173302
12Oxidative phosphorylation_Homo sapiens_hsa001901.91286542
13Butanoate metabolism_Homo sapiens_hsa006501.87787715
14Sphingolipid metabolism_Homo sapiens_hsa006001.73229705
15Vitamin B6 metabolism_Homo sapiens_hsa007501.68419705
16Axon guidance_Homo sapiens_hsa043601.57164301
17Histidine metabolism_Homo sapiens_hsa003401.52982159
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.47096221
19Linoleic acid metabolism_Homo sapiens_hsa005911.43740754
20GABAergic synapse_Homo sapiens_hsa047271.39339387
21Circadian rhythm_Homo sapiens_hsa047101.37453032
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35396052
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33978246
24Glutamatergic synapse_Homo sapiens_hsa047241.29834647
25Serotonergic synapse_Homo sapiens_hsa047261.28807458
26Alzheimers disease_Homo sapiens_hsa050101.27375489
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27255969
28beta-Alanine metabolism_Homo sapiens_hsa004101.25624835
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23844511
30Parkinsons disease_Homo sapiens_hsa050121.23838280
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23420681
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18658735
33Collecting duct acid secretion_Homo sapiens_hsa049661.18264921
34Vibrio cholerae infection_Homo sapiens_hsa051101.16066429
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13784423
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13464656
37Nitrogen metabolism_Homo sapiens_hsa009101.09617370
38Morphine addiction_Homo sapiens_hsa050321.06611236
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.05933715
40Long-term depression_Homo sapiens_hsa047301.03536434
41Fatty acid metabolism_Homo sapiens_hsa012121.01112699
42Renal cell carcinoma_Homo sapiens_hsa052111.00619608
43Thyroid hormone synthesis_Homo sapiens_hsa049181.00292180
44Propanoate metabolism_Homo sapiens_hsa006400.98339276
45Arginine biosynthesis_Homo sapiens_hsa002200.97699215
46Type II diabetes mellitus_Homo sapiens_hsa049300.96795396
47Tryptophan metabolism_Homo sapiens_hsa003800.96133216
48Arginine and proline metabolism_Homo sapiens_hsa003300.95462475
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95254533
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91164602
51Cocaine addiction_Homo sapiens_hsa050300.90708286
52Protein digestion and absorption_Homo sapiens_hsa049740.89331295
53Bile secretion_Homo sapiens_hsa049760.87699013
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86201422
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85977399
56Other glycan degradation_Homo sapiens_hsa005110.83350085
57Circadian entrainment_Homo sapiens_hsa047130.82488595
58Lysosome_Homo sapiens_hsa041420.82239890
59Nicotine addiction_Homo sapiens_hsa050330.81357012
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80222992
61Inositol phosphate metabolism_Homo sapiens_hsa005620.80042647
62Glucagon signaling pathway_Homo sapiens_hsa049220.79871422
63Type I diabetes mellitus_Homo sapiens_hsa049400.79557234
64Tight junction_Homo sapiens_hsa045300.78791682
65Synaptic vesicle cycle_Homo sapiens_hsa047210.74438155
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74291529
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.74203559
68Salivary secretion_Homo sapiens_hsa049700.73384276
69Calcium signaling pathway_Homo sapiens_hsa040200.72521291
70Rheumatoid arthritis_Homo sapiens_hsa053230.72263471
71Arachidonic acid metabolism_Homo sapiens_hsa005900.71491011
72Gastric acid secretion_Homo sapiens_hsa049710.71267441
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.71027897
74Cardiac muscle contraction_Homo sapiens_hsa042600.70921339
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70285119
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69756747
77Ovarian steroidogenesis_Homo sapiens_hsa049130.69658609
78Endocytosis_Homo sapiens_hsa041440.69321730
79Peroxisome_Homo sapiens_hsa041460.66692147
80Dopaminergic synapse_Homo sapiens_hsa047280.65782033
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.64636938
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.64479744
83Mineral absorption_Homo sapiens_hsa049780.64270907
84Fatty acid degradation_Homo sapiens_hsa000710.63064410
85Glutathione metabolism_Homo sapiens_hsa004800.62370399
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62168932
87Ras signaling pathway_Homo sapiens_hsa040140.61483017
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61101361
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61018223
90Oxytocin signaling pathway_Homo sapiens_hsa049210.60594221
91Complement and coagulation cascades_Homo sapiens_hsa046100.60379777
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60243389
93Cholinergic synapse_Homo sapiens_hsa047250.60196802
94Melanogenesis_Homo sapiens_hsa049160.59980268
95PPAR signaling pathway_Homo sapiens_hsa033200.59036292
96Pancreatic secretion_Homo sapiens_hsa049720.54671931
97Huntingtons disease_Homo sapiens_hsa050160.54416373
98Estrogen signaling pathway_Homo sapiens_hsa049150.54389060
99GnRH signaling pathway_Homo sapiens_hsa049120.54358409
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.54155891
101Amphetamine addiction_Homo sapiens_hsa050310.53210263
102Selenocompound metabolism_Homo sapiens_hsa004500.51736338
103ErbB signaling pathway_Homo sapiens_hsa040120.50929162
104Renin secretion_Homo sapiens_hsa049240.49615764
105Autoimmune thyroid disease_Homo sapiens_hsa053200.48583490
106Phototransduction_Homo sapiens_hsa047440.48302176
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46473145
108Taste transduction_Homo sapiens_hsa047420.46403204
109Vitamin digestion and absorption_Homo sapiens_hsa049770.46349164
110Phagosome_Homo sapiens_hsa041450.44215894
111Metabolic pathways_Homo sapiens_hsa011000.41851219
112Tyrosine metabolism_Homo sapiens_hsa003500.40582608
113Fatty acid biosynthesis_Homo sapiens_hsa000610.40542902
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40296354
115Dorso-ventral axis formation_Homo sapiens_hsa043200.40240767
116Insulin secretion_Homo sapiens_hsa049110.39379962
117Regulation of autophagy_Homo sapiens_hsa041400.38917070
118cAMP signaling pathway_Homo sapiens_hsa040240.38669681
119Gap junction_Homo sapiens_hsa045400.37631963
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37235176
121Prion diseases_Homo sapiens_hsa050200.37161595
122Retinol metabolism_Homo sapiens_hsa008300.37086221
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36983906
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.36795554
125Choline metabolism in cancer_Homo sapiens_hsa052310.35842909
126ECM-receptor interaction_Homo sapiens_hsa045120.35692760
127Hedgehog signaling pathway_Homo sapiens_hsa043400.35358012
128Long-term potentiation_Homo sapiens_hsa047200.34501561
129ABC transporters_Homo sapiens_hsa020100.32878932
130Folate biosynthesis_Homo sapiens_hsa007900.32301010
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30769356

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