ENPP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)7.40099860
2intestinal absorption (GO:0050892)7.10787708
3parturition (GO:0007567)6.77830591
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.64654388
5regulation of triglyceride catabolic process (GO:0010896)5.56988609
6L-phenylalanine catabolic process (GO:0006559)5.46849777
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.46849777
8angiotensin maturation (GO:0002003)5.46082880
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.32511059
10L-phenylalanine metabolic process (GO:0006558)5.32511059
11regulation of cholesterol esterification (GO:0010872)5.27902970
12phospholipid efflux (GO:0033700)5.17882443
13cysteine metabolic process (GO:0006534)5.14220888
14aromatic amino acid family catabolic process (GO:0009074)5.11790030
15drug catabolic process (GO:0042737)5.05627896
16high-density lipoprotein particle remodeling (GO:0034375)5.03068541
17negative regulation of sterol transport (GO:0032372)5.02554493
18negative regulation of cholesterol transport (GO:0032375)5.02554493
19diacylglycerol metabolic process (GO:0046339)5.01562102
20urea metabolic process (GO:0019627)4.97864067
21urea cycle (GO:0000050)4.97864067
22positive regulation of triglyceride lipase activity (GO:0061365)4.95101323
23positive regulation of lipoprotein lipase activity (GO:0051006)4.95101323
24homocysteine metabolic process (GO:0050667)4.86055516
25indole-containing compound catabolic process (GO:0042436)4.84367099
26indolalkylamine catabolic process (GO:0046218)4.84367099
27tryptophan catabolic process (GO:0006569)4.84367099
28kynurenine metabolic process (GO:0070189)4.80023524
29reverse cholesterol transport (GO:0043691)4.78174455
30plasma lipoprotein particle assembly (GO:0034377)4.76389479
31cholesterol efflux (GO:0033344)4.75019323
32lipoprotein transport (GO:0042953)4.74652799
33glyoxylate metabolic process (GO:0046487)4.68943080
34alpha-linolenic acid metabolic process (GO:0036109)4.68360844
35lysine metabolic process (GO:0006553)4.63646998
36lysine catabolic process (GO:0006554)4.63646998
37flavonoid metabolic process (GO:0009812)4.59966634
38tryptophan metabolic process (GO:0006568)4.55257221
39nitrogen cycle metabolic process (GO:0071941)4.53054029
40bile acid biosynthetic process (GO:0006699)4.51241071
41low-density lipoprotein particle remodeling (GO:0034374)4.46602679
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.45175046
43plasma lipoprotein particle remodeling (GO:0034369)4.44211414
44protein-lipid complex remodeling (GO:0034368)4.44211414
45macromolecular complex remodeling (GO:0034367)4.44211414
46very-low-density lipoprotein particle assembly (GO:0034379)4.40587702
47serine family amino acid catabolic process (GO:0009071)4.38730900
48lipoprotein metabolic process (GO:0042157)4.37531553
49protein-lipid complex assembly (GO:0065005)4.37035616
50negative regulation of protein activation cascade (GO:2000258)4.34414453
51cholesterol homeostasis (GO:0042632)4.32728691
52sterol homeostasis (GO:0055092)4.27898575
53regulation of bile acid biosynthetic process (GO:0070857)4.23361755
54lung vasculature development (GO:0060426)4.22445623
55negative regulation of complement activation (GO:0045916)4.15635513
56epoxygenase P450 pathway (GO:0019373)4.15306055
57acylglycerol homeostasis (GO:0055090)4.14518527
58triglyceride homeostasis (GO:0070328)4.14518527
59amino-acid betaine metabolic process (GO:0006577)4.13384009
60sulfur amino acid catabolic process (GO:0000098)4.11733805
61regulation of protein activation cascade (GO:2000257)4.11239844
62sulfate transmembrane transport (GO:1902358)4.08100340
63complement activation, alternative pathway (GO:0006957)4.04454582
643-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.01197788
65purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.01197788
66regulation of cholesterol homeostasis (GO:2000188)3.99590775
67regulation of apoptotic cell clearance (GO:2000425)3.98023895
68bile acid metabolic process (GO:0008206)3.95444775
69drug transmembrane transport (GO:0006855)3.93326826
70regulation of complement activation (GO:0030449)3.92937741
71serine family amino acid metabolic process (GO:0009069)3.91532782
72bile acid and bile salt transport (GO:0015721)3.91436577
73glycine metabolic process (GO:0006544)3.90746845
74hormone catabolic process (GO:0042447)3.89320309
75regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.86186139
76plasma lipoprotein particle clearance (GO:0034381)3.85804787
77serine family amino acid biosynthetic process (GO:0009070)3.84745337
78regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.83672025
79cellular glucuronidation (GO:0052695)3.83047347
80negative regulation of fibrinolysis (GO:0051918)3.82249140
81heme transport (GO:0015886)3.79097823
82insulin-like growth factor receptor signaling pathway (GO:0048009)3.78038404
83positive regulation of glycolytic process (GO:0045821)3.75447039
84aromatic amino acid family metabolic process (GO:0009072)3.74936502
85urate metabolic process (GO:0046415)3.74214467
86positive regulation of lipid catabolic process (GO:0050996)3.73051948
87exogenous drug catabolic process (GO:0042738)3.71087501
88drug transport (GO:0015893)3.68581804
89modified amino acid transport (GO:0072337)3.68340014
90vitamin A metabolic process (GO:0006776)3.67419576
91regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.66953807
92endocrine process (GO:0050886)3.66953807
93regulation of systemic arterial blood pressure by hormone (GO:0001990)3.66953807
94exocrine pancreas development (GO:0031017)3.66879946
95protein carboxylation (GO:0018214)3.66862389
96peptidyl-glutamic acid carboxylation (GO:0017187)3.66862389
97alpha-amino acid catabolic process (GO:1901606)3.64481235
98positive regulation of fatty acid biosynthetic process (GO:0045723)3.64389610
99regulation of fibrinolysis (GO:0051917)3.64326004
100cellular zinc ion homeostasis (GO:0006882)3.61375672
101plasma lipoprotein particle organization (GO:0071827)3.60112188
102positive regulation of triglyceride metabolic process (GO:0090208)3.59350771
103drug metabolic process (GO:0017144)3.56382692
104glutamate metabolic process (GO:0006536)3.55516887
105sterol transport (GO:0015918)3.55152050
106cholesterol transport (GO:0030301)3.55152050
107cellular modified amino acid catabolic process (GO:0042219)3.50996087
108vitamin transmembrane transport (GO:0035461)3.49958478
109response to nitrosative stress (GO:0051409)3.47618470
110imidazole-containing compound metabolic process (GO:0052803)3.46500149
111phospholipid homeostasis (GO:0055091)3.46452916
112protein-lipid complex subunit organization (GO:0071825)3.44763319
113cellular amino acid catabolic process (GO:0009063)3.41203149
114ethanol oxidation (GO:0006069)3.41130204
115acetyl-CoA metabolic process (GO:0006084)3.38457535
116glucuronate metabolic process (GO:0019585)3.36910184
117uronic acid metabolic process (GO:0006063)3.36910184
118indolalkylamine metabolic process (GO:0006586)3.36242056
119proline metabolic process (GO:0006560)3.36006488
120lung lobe morphogenesis (GO:0060463)3.34959905
121lipid homeostasis (GO:0055088)3.33689003
122benzene-containing compound metabolic process (GO:0042537)3.33374383
123negative regulation of humoral immune response (GO:0002921)3.32221041
124sulfate transport (GO:0008272)3.28491812
125drinking behavior (GO:0042756)3.27974837
126glycerol metabolic process (GO:0006071)3.20467411
127proline biosynthetic process (GO:0006561)3.19636046
128phenol-containing compound catabolic process (GO:0019336)3.18840816
129positive regulation of cellular amine metabolic process (GO:0033240)3.12640241
130fat-soluble vitamin biosynthetic process (GO:0042362)3.11206448
131blood coagulation, intrinsic pathway (GO:0007597)3.09079298
132complement activation, classical pathway (GO:0006958)3.00628360
133positive regulation of cardiac muscle hypertrophy (GO:0010613)2.97963585
134positive regulation of muscle hypertrophy (GO:0014742)2.97963585
135alditol metabolic process (GO:0019400)2.96162882
136prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.95980602
137COPII vesicle coating (GO:0048208)2.95419567
138regulation of guanylate cyclase activity (GO:0031282)2.95354361
139positive regulation of protein import into nucleus, translocation (GO:0033160)2.93701330
140negative regulation of metanephros development (GO:0072217)2.89218003
141negative regulation of coagulation (GO:0050819)2.88933720
142regulation of cholesterol metabolic process (GO:0090181)2.86974001
143regulation of lipoprotein metabolic process (GO:0050746)2.86234418
144regulation of systemic arterial blood pressure (GO:0003073)2.85258719
145glutamine family amino acid biosynthetic process (GO:0009084)2.83188399
146short-chain fatty acid metabolic process (GO:0046459)2.76770650
147fructose metabolic process (GO:0006000)2.76168309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.66792863
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.94968691
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.66462732
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.10542124
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.49355101
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.38866046
7TP63_17297297_ChIP-ChIP_HaCaT_Human4.09093236
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.08874330
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.91693036
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.70579743
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.40114051
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.06808834
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.96104772
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.92371045
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.89578157
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.45916201
17CLOCK_20551151_ChIP-Seq_293T_Human2.25398123
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07310181
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.06111217
20* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.02506674
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.88674562
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88091557
23AR_21909140_ChIP-Seq_LNCAP_Human1.83028456
24GATA4_25053715_ChIP-Seq_YYC3_Human1.79159907
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.76878672
26* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76759433
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76154039
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73423337
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72333337
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72037037
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.71886186
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70827591
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70814897
34* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59229615
35HNF4A_19822575_ChIP-Seq_HepG2_Human1.57899821
36ZNF263_19887448_ChIP-Seq_K562_Human1.57441893
37CDX2_22108803_ChIP-Seq_LS180_Human1.55869693
38GATA6_25053715_ChIP-Seq_YYC3_Human1.54980840
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.52132953
40FOXA1_25552417_ChIP-Seq_VCAP_Human1.51966743
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.50952431
42AR_21572438_ChIP-Seq_LNCaP_Human1.50422827
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.47227274
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40807299
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.39611238
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.39298241
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33614053
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33534862
49GATA2_19941826_ChIP-Seq_K562_Human1.33291892
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33147751
51GATA1_19941826_ChIP-Seq_K562_Human1.30309747
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.29916374
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27522491
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25280003
55* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23985087
56* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23853135
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22835620
58RXR_22108803_ChIP-Seq_LS180_Human1.22383436
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20737990
60GATA1_22025678_ChIP-Seq_K562_Human1.18470887
61* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14789731
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14446648
63SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14193378
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13863713
65AHR_22903824_ChIP-Seq_MCF-7_Human1.13227646
66* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12463536
67VDR_22108803_ChIP-Seq_LS180_Human1.12282281
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11578838
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.09824150
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07119863
71* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03484521
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.02604118
73OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02507269
74SOX2_20726797_ChIP-Seq_SW620_Human1.01405352
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01206007
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.01014197
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97818517
78* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95917074
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95674212
80NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95307120
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93732465
82* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93347330
83HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93156580
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92838075
85TP53_16413492_ChIP-PET_HCT116_Human0.91154200
86POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90867000
87ATF3_27146783_Chip-Seq_COLON_Human0.90236342
88TP63_23658742_ChIP-Seq_EP156T_Human0.88764380
89CEBPB_22108803_ChIP-Seq_LS180_Human0.88699269
90TCF4_22108803_ChIP-Seq_LS180_Human0.87982254
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87462978
92RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87397499
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.86361199
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.85711748
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85529701
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84168922
97RACK7_27058665_Chip-Seq_MCF-7_Human0.83628279
98* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83475384
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82797330
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82797330
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82072811
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81580629
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81280676
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80074802
105CJUN_26792858_Chip-Seq_BT549_Human0.79585831
106PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79241248
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79029929
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.78993327
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78618413
110* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78330977
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77992797
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.77939448
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77889729
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76984179
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76836671
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76836671
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76836671
118* STAT3_23295773_ChIP-Seq_U87_Human0.76646462
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76429311
120BCAT_22108803_ChIP-Seq_LS180_Human0.76417245
121ER_23166858_ChIP-Seq_MCF-7_Human0.74468511
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74399214
123* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.73660188
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73370194
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72825846
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72196590
127TP53_18474530_ChIP-ChIP_U2OS_Human0.71514420
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.69162314
129KLF5_20875108_ChIP-Seq_MESCs_Mouse0.68026961
130SMAD4_21799915_ChIP-Seq_A2780_Human0.67735558
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.67670848
132TCF4_23295773_ChIP-Seq_U87_Human0.67661078
133KAP1_27257070_Chip-Seq_ESCs_Mouse0.67147939
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65926365
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65797661
136* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65628483
137FOXM1_23109430_ChIP-Seq_U2OS_Human0.64562396
138* HTT_18923047_ChIP-ChIP_STHdh_Human0.64502036
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64233451
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.63753947
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.63248959
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.62940444
143NANOG_16518401_ChIP-PET_MESCs_Mouse0.62839594
144* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.62617975
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62142247
146NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62038138
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.61293311
148E2F7_22180533_ChIP-Seq_HELA_Human0.60954704
149RUNX1_27514584_Chip-Seq_MCF-7_Human0.60750789
150CREB1_26743006_Chip-Seq_LNCaP_Human0.60637289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.22458816
2MP0002139_abnormal_hepatobiliary_system6.83593615
3MP0005085_abnormal_gallbladder_physiolo5.41078090
4MP0005365_abnormal_bile_salt4.46721113
5MP0008875_abnormal_xenobiotic_pharmacok4.32391424
6MP0001666_abnormal_nutrient_absorption4.31512252
7MP0010386_abnormal_urinary_bladder4.21132720
8MP0003252_abnormal_bile_duct4.18153820
9MP0003806_abnormal_nucleotide_metabolis4.01423393
10MP0009840_abnormal_foam_cell3.78562166
11MP0010329_abnormal_lipoprotein_level3.30334729
12MP0002160_abnormal_reproductive_system2.77593648
13MP0004019_abnormal_vitamin_homeostasis2.66098186
14MP0005332_abnormal_amino_acid2.47587508
15MP0008004_abnormal_stomach_pH2.32905871
16MP0003705_abnormal_hypodermis_morpholog2.12048785
17MP0002254_reproductive_system_inflammat2.05494470
18MP0010234_abnormal_vibrissa_follicle1.95007541
19MP0000609_abnormal_liver_physiology1.76931189
20MP0003191_abnormal_cellular_cholesterol1.73412135
21MP0009697_abnormal_copulation1.72316347
22MP0002132_abnormal_respiratory_system1.68634011
23MP0005389_reproductive_system_phenotype1.67213983
24MP0002118_abnormal_lipid_homeostasis1.67112857
25MP0004272_abnormal_basement_membrane1.63916990
26MP0004264_abnormal_extraembryonic_tissu1.62266319
27MP0003195_calcinosis1.61811114
28MP0005083_abnormal_biliary_tract1.57229974
29MP0005319_abnormal_enzyme/_coenzyme1.49461042
30MP0009643_abnormal_urine_homeostasis1.40543751
31MP0003122_maternal_imprinting1.39419343
32MP0005670_abnormal_white_adipose1.39293599
33MP0002138_abnormal_hepatobiliary_system1.32849267
34MP0009053_abnormal_anal_canal1.31851007
35MP0001764_abnormal_homeostasis1.30095135
36MP0003718_maternal_effect1.29327180
37MP0005084_abnormal_gallbladder_morpholo1.21995573
38MP0000678_abnormal_parathyroid_gland1.21927432
39MP0003879_abnormal_hair_cell1.21516331
40MP0004043_abnormal_pH_regulation1.16734017
41MP0000462_abnormal_digestive_system1.14754610
42MP0005409_darkened_coat_color1.12590790
43MP0003868_abnormal_feces_composition1.08482962
44MP0000627_abnormal_mammary_gland1.05853590
45MP0003724_increased_susceptibility_to1.05685525
46MP0005584_abnormal_enzyme/coenzyme_acti1.03142085
47MP0002796_impaired_skin_barrier1.01072295
48MP0003950_abnormal_plasma_membrane1.00871318
49MP0005164_abnormal_response_to1.00706630
50MP0000598_abnormal_liver_morphology0.94559500
51MP0005266_abnormal_metabolism0.93207015
52MP0009780_abnormal_chondrocyte_physiolo0.90250937
53MP0010155_abnormal_intestine_physiology0.89040622
54MP0010352_gastrointestinal_tract_polyps0.88834200
55MP0002876_abnormal_thyroid_physiology0.88332682
56MP0005636_abnormal_mineral_homeostasis0.87559431
57MP0001915_intracranial_hemorrhage0.87402104
58MP0005451_abnormal_body_composition0.86325357
59MP0003183_abnormal_peptide_metabolism0.86035657
60MP0003186_abnormal_redox_activity0.83878218
61MP0004883_abnormal_blood_vessel0.81203067
62MP0000639_abnormal_adrenal_gland0.80746331
63MP0003632_abnormal_nervous_system0.79117469
64MP0005376_homeostasis/metabolism_phenot0.79014619
65MP0000537_abnormal_urethra_morphology0.78569046
66MP0001873_stomach_inflammation0.77207920
67MP0004147_increased_porphyrin_level0.76895714
68MP0003953_abnormal_hormone_level0.74101943
69MP0005448_abnormal_energy_balance0.73402100
70MP0002136_abnormal_kidney_physiology0.73041749
71MP0003938_abnormal_ear_development0.72571813
72MP0001881_abnormal_mammary_gland0.71231077
73MP0003656_abnormal_erythrocyte_physiolo0.70326234
74MP0009642_abnormal_blood_homeostasis0.69845333
75MP0001756_abnormal_urination0.69773694
76MP0000538_abnormal_urinary_bladder0.69685588
77MP0005395_other_phenotype0.69083569
78MP0005377_hearing/vestibular/ear_phenot0.66687124
79MP0003878_abnormal_ear_physiology0.66687124
80MP0000467_abnormal_esophagus_morphology0.66386898
81MP0001501_abnormal_sleep_pattern0.66129825
82MP0001849_ear_inflammation0.65707550
83MP0005408_hypopigmentation0.65439685
84MP0009765_abnormal_xenobiotic_induced0.65110364
85MP0009384_cardiac_valve_regurgitation0.64095836
86MP0005501_abnormal_skin_physiology0.63128654
87MP0005023_abnormal_wound_healing0.59176181
88MP0005167_abnormal_blood-brain_barrier0.58107899
89MP0001664_abnormal_digestion0.57675582
90MP0009763_increased_sensitivity_to0.57475228
91MP0000477_abnormal_intestine_morphology0.57275720
92MP0003300_gastrointestinal_ulcer0.56739348
93MP0003011_delayed_dark_adaptation0.56714027
94MP0009764_decreased_sensitivity_to0.56422570
95MP0000920_abnormal_myelination0.55702042
96MP0002971_abnormal_brown_adipose0.55374803
97MP0003453_abnormal_keratinocyte_physiol0.55169023
98MP0002938_white_spotting0.54901315
99MP0005410_abnormal_fertilization0.54839204
100MP0000604_amyloidosis0.54508310
101MP0002933_joint_inflammation0.54251505
102MP0003943_abnormal_hepatobiliary_system0.53977686
103MP0003123_paternal_imprinting0.53856566
104MP0002909_abnormal_adrenal_gland0.53378384
105MP0000383_abnormal_hair_follicle0.52885487
106MP0003699_abnormal_female_reproductive0.51767482
107MP0003638_abnormal_response/metabolism_0.51615895
108MP0002089_abnormal_postnatal_growth/wei0.51487320
109MP0002078_abnormal_glucose_homeostasis0.50907562
110MP0008469_abnormal_protein_level0.50859517
111MP0002135_abnormal_kidney_morphology0.50567848
112MP0001270_distended_abdomen0.50221883
113MP0010368_abnormal_lymphatic_system0.49946013
114MP0005666_abnormal_adipose_tissue0.48414043
115MP0002060_abnormal_skin_morphology0.47365482
116MP0000534_abnormal_ureter_morphology0.46578505
117MP0003315_abnormal_perineum_morphology0.46481838
118MP0005647_abnormal_sex_gland0.46375566
119MP0000230_abnormal_systemic_arterial0.46296051
120MP0005381_digestive/alimentary_phenotyp0.46279821
121MP0003631_nervous_system_phenotype0.46246363
122MP0003633_abnormal_nervous_system0.45781091
123MP0000579_abnormal_nail_morphology0.45504718
124MP0006036_abnormal_mitochondrial_physio0.45421412
125MP0006054_spinal_hemorrhage0.45390544
126MP0003941_abnormal_skin_development0.45364642
127MP0010678_abnormal_skin_adnexa0.44811546
128MP0000566_synostosis0.44710964
129MP0002098_abnormal_vibrissa_morphology0.44544900
130MP0005334_abnormal_fat_pad0.44248853
131MP0003119_abnormal_digestive_system0.42243998
132MP0005220_abnormal_exocrine_pancreas0.42117725
133MP0001661_extended_life_span0.41950634
134MP0009379_abnormal_foot_pigmentation0.39732108
135MP0009115_abnormal_fat_cell0.39232543
136MP0009672_abnormal_birth_weight0.39062235
137MP0001730_embryonic_growth_arrest0.38304389
138MP0008873_increased_physiological_sensi0.37706712
139MP0000377_abnormal_hair_follicle0.36930601
140MP0001663_abnormal_digestive_system0.35417834
141MP0002822_catalepsy0.34514739
142MP0003866_abnormal_defecation0.34277421
143MP0008872_abnormal_physiological_respon0.34162156
144MP0001765_abnormal_ion_homeostasis0.33613375

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)7.48936631
2Intrahepatic cholestasis (HP:0001406)6.56841527
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.16205359
4Abnormality of glutamine family amino acid metabolism (HP:0010902)6.11625336
5Xanthomatosis (HP:0000991)5.82336323
6Flat acetabular roof (HP:0003180)5.31796265
7Hyperglycinuria (HP:0003108)5.30808673
8Deep venous thrombosis (HP:0002625)5.15983434
9Hypolipoproteinemia (HP:0010981)5.12672130
10Abnormality of aromatic amino acid family metabolism (HP:0004338)5.02137500
11Fat malabsorption (HP:0002630)4.65738468
12Abnormality of serine family amino acid metabolism (HP:0010894)4.65455216
13Abnormality of glycine metabolism (HP:0010895)4.65455216
14Acanthocytosis (HP:0001927)4.57270822
15Conjugated hyperbilirubinemia (HP:0002908)4.48038945
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42381044
17Epidermoid cyst (HP:0200040)4.35736101
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.34175339
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.27666787
20Neonatal short-limb short stature (HP:0008921)4.12285031
21Prolonged partial thromboplastin time (HP:0003645)4.11106904
22Hyperammonemia (HP:0001987)4.07593430
23Hyperglycinemia (HP:0002154)4.03968529
24Complement deficiency (HP:0004431)4.03258886
25Malnutrition (HP:0004395)3.97143840
26Abnormality of proline metabolism (HP:0010907)3.84889290
27Hydroxyprolinuria (HP:0003080)3.84889290
28Glomerulonephritis (HP:0000099)3.82259472
29Abnormality of pyrimidine metabolism (HP:0004353)3.80725482
30Ileus (HP:0002595)3.70800603
31Hyperlipoproteinemia (HP:0010980)3.56607169
32Hypercholesterolemia (HP:0003124)3.53550571
33Abnormality of nucleobase metabolism (HP:0010932)3.53271914
34Hypoalphalipoproteinemia (HP:0003233)3.49897813
35Abnormality of purine metabolism (HP:0004352)3.39545130
36Ketosis (HP:0001946)3.25525449
37Hemorrhage of the eye (HP:0011885)3.22304909
38Autoimmune thrombocytopenia (HP:0001973)3.15369077
39Abnormality of the common coagulation pathway (HP:0010990)3.14060520
40Hypoglycemic coma (HP:0001325)3.12208556
41Abnormality of methionine metabolism (HP:0010901)3.03438246
42Irregular epiphyses (HP:0010582)2.97185042
43Poikilocytosis (HP:0004447)2.94159831
44Abnormality of complement system (HP:0005339)2.92615320
45Gout (HP:0001997)2.91129893
46Focal segmental glomerulosclerosis (HP:0000097)2.90422630
47Breech presentation (HP:0001623)2.88747756
48Hyperbilirubinemia (HP:0002904)2.87969244
49Glomerulosclerosis (HP:0000096)2.80002638
50Abnormality of fatty-acid metabolism (HP:0004359)2.79459448
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77674621
52Metabolic acidosis (HP:0001942)2.73281951
53Spastic diplegia (HP:0001264)2.69462000
54Visceral angiomatosis (HP:0100761)2.62445436
55Abnormality of the vitamin B12 metabolism (HP:0004341)2.60537897
56Skin nodule (HP:0200036)2.58784151
57Joint hemorrhage (HP:0005261)2.58428637
58Abnormality of the intrinsic pathway (HP:0010989)2.58422898
59Menorrhagia (HP:0000132)2.56366985
60Steatorrhea (HP:0002570)2.56105704
61Vascular calcification (HP:0004934)2.55998278
62Delayed CNS myelination (HP:0002188)2.55905754
63Hypothermia (HP:0002045)2.55427435
64Ketoacidosis (HP:0001993)2.55368544
65Pigmentary retinal degeneration (HP:0001146)2.51237033
66Hemangiomatosis (HP:0007461)2.49486165
67Hyperactive renin-angiotensin system (HP:0000841)2.49319961
68Reticulocytosis (HP:0001923)2.48726786
69Hepatocellular carcinoma (HP:0001402)2.48316390
70Enlarged kidneys (HP:0000105)2.47603812
71Nephritis (HP:0000123)2.47080622
72Hypophosphatemic rickets (HP:0004912)2.46102124
73Flat capital femoral epiphysis (HP:0003370)2.45582813
74Abnormality of urine glucose concentration (HP:0011016)2.44917544
75Glycosuria (HP:0003076)2.44917544
76Abnormality of serum amino acid levels (HP:0003112)2.44732998
77Mitral stenosis (HP:0001718)2.44510571
78Widely patent fontanelles and sutures (HP:0004492)2.43966876
79Abnormality of carpal bone ossification (HP:0006257)2.42078515
80Abnormal tarsal ossification (HP:0008369)2.40914597
81Cardiovascular calcification (HP:0011915)2.40596310
82Cupped ribs (HP:0000887)2.39419195
83Nephrolithiasis (HP:0000787)2.37734151
84Right ventricular cardiomyopathy (HP:0011663)2.35313889
85Abnormality of vitamin B metabolism (HP:0004340)2.35028686
86Abnormality of the acetabulum (HP:0003170)2.32234778
87Flattened epiphyses (HP:0003071)2.31539465
88Myocardial infarction (HP:0001658)2.31348867
89Vertebral hypoplasia (HP:0008417)2.24724015
90Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.24724015
91Lethargy (HP:0001254)2.22068665
92Systemic lupus erythematosus (HP:0002725)2.21295655
93Facial shape deformation (HP:0011334)2.18851813
94Potter facies (HP:0002009)2.18851813
95Irritability (HP:0000737)2.18680284
96Chronic diarrhea (HP:0002028)2.18240870
97Proximal tubulopathy (HP:0000114)2.17677449
98Limited elbow extension (HP:0001377)2.17670539
99Mesangial abnormality (HP:0001966)2.17126747
100Increased mean platelet volume (HP:0011877)2.16389487
101Hyperuricemia (HP:0002149)2.14403451
102Increased purine levels (HP:0004368)2.14403451
103Cholecystitis (HP:0001082)2.14196535
104Abnormal gallbladder physiology (HP:0012438)2.14196535
105Esophageal varix (HP:0002040)2.13464971
106Decreased circulating renin level (HP:0003351)2.10549957
107Rickets (HP:0002748)2.10385328
108Abnormal gallbladder morphology (HP:0012437)2.10177444
109Abnormality of vitamin metabolism (HP:0100508)2.09779301
110Cholelithiasis (HP:0001081)2.09676195
111Abnormal cartilage morphology (HP:0002763)2.09341961
112Abnormal glucose tolerance (HP:0001952)2.08958782
113Osteomalacia (HP:0002749)2.07335835
114Large earlobe (HP:0009748)2.06540339
115Dicarboxylic aciduria (HP:0003215)2.04984394
116Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04984394
117Spinal cord compression (HP:0002176)2.04795099
118Confusion (HP:0001289)2.04496073
119Pancreatitis (HP:0001733)2.03382407
120Papillary thyroid carcinoma (HP:0002895)2.02498242
121Abnormality of the nasal septum (HP:0000419)2.01074611
122Nausea (HP:0002018)2.01071377
123Megaloblastic anemia (HP:0001889)1.96965401
124Spontaneous abortion (HP:0005268)1.96889587
125Sensorimotor neuropathy (HP:0007141)1.96677359
126Enlarged epiphyses (HP:0010580)1.96387385
127Abnormal hand bone ossification (HP:0010660)1.96237360
128Hypotension (HP:0002615)1.95163559
129Hyperkalemia (HP:0002153)1.94310589
130Abnormality of transition element cation homeostasis (HP:0011030)1.93714617
131Purpura (HP:0000979)1.93024929
132Abnormal enzyme/coenzyme activity (HP:0012379)1.90142379
133Hypochromic microcytic anemia (HP:0004840)1.89033758
134Hypoglycemic seizures (HP:0002173)1.88894076
135Subcapsular cataract (HP:0000523)1.87468550
136Polycythemia (HP:0001901)1.86940937
137Wide cranial sutures (HP:0010537)1.85180370
138Abnormal vertebral ossification (HP:0100569)1.84668979
139Arthropathy (HP:0003040)1.84003879
140Broad alveolar ridges (HP:0000187)1.83099683
141Autoimmune hemolytic anemia (HP:0001890)1.81370257
142Small epiphyses (HP:0010585)1.81213793
143Alopecia of scalp (HP:0002293)1.80465770
144Hyperglycemia (HP:0003074)1.79899739
145Abdominal distention (HP:0003270)1.79066221
146Scanning speech (HP:0002168)1.78718213
147Generalized aminoaciduria (HP:0002909)1.76150353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.63269618
2PIK3CA4.11286962
3BCKDK3.61447125
4EPHA23.37292305
5MST1R3.12816160
6LATS13.04444075
7AKT33.03500333
8FGFR32.94129976
9ERN12.69120987
10FGFR42.64094867
11SIK12.63754013
12MST42.60425567
13ERBB42.33134372
14NLK2.31772290
15PTK62.18542984
16BRSK22.17649598
17GRK62.12667330
18MAP3K102.06370311
19STK38L2.05252539
20MET1.94327842
21NEK61.77014037
22RET1.68746563
23PKN21.64745683
24NEK11.63154062
25RIPK11.61614160
26LMTK21.60450583
27PDGFRB1.48363898
28JAK11.47525003
29STK391.42290002
30TTK1.38851553
31MAPKAPK31.33965603
32EPHB21.28157170
33CSNK1G11.26564345
34PRKG21.24552739
35TESK21.23695243
36MAPK111.22573084
37ERBB21.22547714
38BCR1.20395846
39FLT31.19372629
40NUAK11.18884241
41TRPM71.17812732
42MAP3K21.17632498
43STK31.15761309
44STK101.15490860
45MAP2K21.12857507
46PDK21.10972437
47CDK61.07726017
48CDK121.07130746
49CDC42BPA1.06322517
50MAP3K81.06266864
51BMX1.05314851
52PTK21.04799230
53FER1.03546700
54PDPK11.02666600
55MAP3K71.02034970
56TGFBR21.00457176
57MAP3K30.99551467
58TAOK30.99214661
59LATS20.98323744
60BMPR20.97597099
61PDK30.96680118
62PDK40.96680118
63EPHB10.93883632
64PBK0.90107450
65WNK10.90094388
66PRKAA20.89902978
67SGK4940.86730819
68SGK2230.86730819
69FGFR20.86290242
70INSRR0.84379451
71PRKCI0.80562738
72NME10.80543391
73DDR20.80197311
74PDK10.79759325
75ICK0.79153830
76MELK0.78422042
77PAK40.78206260
78CAMKK20.77735762
79CDK40.76107844
80CSNK1G30.74694308
81CAMK1D0.73380970
82TYRO30.72927515
83SGK20.72846177
84MTOR0.70152867
85SGK10.65733094
86FGFR10.64844596
87LRRK20.64034434
88KDR0.64028425
89EIF2AK10.63828621
90PRKAA10.63346132
91ACVR1B0.62616279
92WEE10.61769608
93PDGFRA0.60855483
94NEK20.60364152
95WNK30.59876490
96NEK90.59638072
97SGK30.59537450
98MAPKAPK50.59189122
99TYK20.58578884
100MAP3K60.56792148
101GSK3A0.55161115
102RPS6KB20.54036092
103TRIB30.52843348
104JAK20.52459906
105DYRK1B0.51891987
106YES10.51408708
107BUB10.51362826
108AURKB0.51175043
109NTRK30.51006270
110EIF2AK30.50155325
111ABL20.50120452
112AKT20.50106967
113WNK40.49976421
114PIM10.49123104
115CSNK1G20.48413854
116CDK70.48360354
117MAP3K110.48322466
118MAP3K120.48165393
119CCNB10.47925104
120CAMK40.47281510
121MAP3K50.46731722
122PAK20.46261855
123MAP3K40.43793433
124RPS6KB10.43067357
125EPHA30.42902452
126MAP2K10.42419394
127MAP2K30.41831841
128MAP3K10.41515259
129IGF1R0.41097746
130BRD40.39669421
131CAMK1G0.39499057
132MAP2K40.38938853
133KSR20.37595894
134SCYL20.36995066
135PRKCQ0.36980564
136TEC0.36948287
137EEF2K0.36531909
138BRSK10.36249803
139RIPK40.34986450
140PRKACG0.33483047
141PLK10.31918347
142CSNK1E0.31616866
143PAK30.29863179
144PRKCZ0.28718176
145MAP2K60.27303581
146MAPK30.26803401
147STK40.26741430
148MATK0.25345323
149PIK3CG0.23963968

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.40228922
2Fat digestion and absorption_Homo sapiens_hsa049753.23734952
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.01361777
4Nitrogen metabolism_Homo sapiens_hsa009102.95016823
5Caffeine metabolism_Homo sapiens_hsa002322.76556475
6Arginine biosynthesis_Homo sapiens_hsa002202.67603923
7Vitamin digestion and absorption_Homo sapiens_hsa049772.61649191
8Tryptophan metabolism_Homo sapiens_hsa003802.53578171
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.39784032
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.37770201
11Fatty acid degradation_Homo sapiens_hsa000712.22510511
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19723290
13Folate biosynthesis_Homo sapiens_hsa007902.14861343
14Histidine metabolism_Homo sapiens_hsa003402.05635807
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96467314
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95451722
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94325877
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93751337
19Renin-angiotensin system_Homo sapiens_hsa046141.93583463
20PPAR signaling pathway_Homo sapiens_hsa033201.89456131
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87913820
22Bile secretion_Homo sapiens_hsa049761.87436511
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87103860
24Complement and coagulation cascades_Homo sapiens_hsa046101.78646545
25Peroxisome_Homo sapiens_hsa041461.77363442
26* Starch and sucrose metabolism_Homo sapiens_hsa005001.77023419
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.76126148
28Butanoate metabolism_Homo sapiens_hsa006501.72726223
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64402727
30Chemical carcinogenesis_Homo sapiens_hsa052041.60756875
31Selenocompound metabolism_Homo sapiens_hsa004501.59135140
32Mineral absorption_Homo sapiens_hsa049781.57027962
33beta-Alanine metabolism_Homo sapiens_hsa004101.53832046
34Sulfur metabolism_Homo sapiens_hsa009201.53575478
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.52846312
36Fatty acid metabolism_Homo sapiens_hsa012121.52804334
37* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52542067
38Propanoate metabolism_Homo sapiens_hsa006401.52452035
39Retinol metabolism_Homo sapiens_hsa008301.48456666
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44416468
41Pyruvate metabolism_Homo sapiens_hsa006201.44062907
42Galactose metabolism_Homo sapiens_hsa000521.43011923
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41310749
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.39966453
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.37712358
46Biosynthesis of amino acids_Homo sapiens_hsa012301.31205879
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31125514
48Glutathione metabolism_Homo sapiens_hsa004801.28909731
49Carbon metabolism_Homo sapiens_hsa012001.28049468
50Arginine and proline metabolism_Homo sapiens_hsa003301.18695971
51Phenylalanine metabolism_Homo sapiens_hsa003601.18334892
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.15563498
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.12842643
54ABC transporters_Homo sapiens_hsa020101.11072266
55Steroid biosynthesis_Homo sapiens_hsa001001.07615817
56Tyrosine metabolism_Homo sapiens_hsa003500.99949033
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99072058
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96655143
59Glycerolipid metabolism_Homo sapiens_hsa005610.93676523
60Protein digestion and absorption_Homo sapiens_hsa049740.92406588
61Vitamin B6 metabolism_Homo sapiens_hsa007500.92250008
62Other glycan degradation_Homo sapiens_hsa005110.91178147
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90634966
64Lysine degradation_Homo sapiens_hsa003100.88101457
65Fructose and mannose metabolism_Homo sapiens_hsa000510.87127148
66Staphylococcus aureus infection_Homo sapiens_hsa051500.86361843
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85874060
68One carbon pool by folate_Homo sapiens_hsa006700.85503198
69Fatty acid elongation_Homo sapiens_hsa000620.85486152
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84690166
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78635275
72Pentose phosphate pathway_Homo sapiens_hsa000300.74354438
73* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67152197
74Fatty acid biosynthesis_Homo sapiens_hsa000610.67011499
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66342958
76Circadian rhythm_Homo sapiens_hsa047100.57312950
77Sulfur relay system_Homo sapiens_hsa041220.54975230
78Ovarian steroidogenesis_Homo sapiens_hsa049130.51351793
79* Metabolic pathways_Homo sapiens_hsa011000.47381067
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46916469
81African trypanosomiasis_Homo sapiens_hsa051430.45873708
82Ether lipid metabolism_Homo sapiens_hsa005650.44095068
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38599412
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.36283271
85mTOR signaling pathway_Homo sapiens_hsa041500.34096367
86N-Glycan biosynthesis_Homo sapiens_hsa005100.33108290
87HIF-1 signaling pathway_Homo sapiens_hsa040660.31491602
88Linoleic acid metabolism_Homo sapiens_hsa005910.26688281
89Choline metabolism in cancer_Homo sapiens_hsa052310.26144568
90FoxO signaling pathway_Homo sapiens_hsa040680.25361609
91Insulin resistance_Homo sapiens_hsa049310.22142105
92Prostate cancer_Homo sapiens_hsa052150.14300341
93Pertussis_Homo sapiens_hsa051330.13373796
94Prion diseases_Homo sapiens_hsa050200.12637693
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11301015
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10579776
97Cocaine addiction_Homo sapiens_hsa050300.10239515
98Bladder cancer_Homo sapiens_hsa052190.08936426
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.08422011
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07666481
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.06339756
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.05622061
103Thyroid hormone synthesis_Homo sapiens_hsa049180.04295681
104Arachidonic acid metabolism_Homo sapiens_hsa005900.03319592
105AMPK signaling pathway_Homo sapiens_hsa041520.02503362
106Amoebiasis_Homo sapiens_hsa05146-0.1430930
107Thyroid cancer_Homo sapiens_hsa05216-0.1317265
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1305822
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1180362
110Pyrimidine metabolism_Homo sapiens_hsa00240-0.1177354
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1087692
112Hepatitis C_Homo sapiens_hsa05160-0.1037615
113Adherens junction_Homo sapiens_hsa04520-0.0721999
114Glucagon signaling pathway_Homo sapiens_hsa04922-0.0538385
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0515373
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0456793
117Tight junction_Homo sapiens_hsa04530-0.0453516
118Sphingolipid metabolism_Homo sapiens_hsa00600-0.0166452

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