ENPP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type-I transmembrane glycoprotein. Studies in rat suggest the encoded protein may play a role in neuronal cell communications. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.54073546
2synaptic vesicle maturation (GO:0016188)5.21214548
3synaptic vesicle exocytosis (GO:0016079)5.13552941
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.85670725
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.83007035
6regulation of synaptic vesicle exocytosis (GO:2000300)4.76713343
7vocalization behavior (GO:0071625)4.74050555
8locomotory exploration behavior (GO:0035641)4.70500952
9glutamate secretion (GO:0014047)4.70341331
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.57761460
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.37440054
12neurotransmitter secretion (GO:0007269)4.35622805
13neuronal action potential propagation (GO:0019227)4.31780468
14axonemal dynein complex assembly (GO:0070286)4.28391469
15regulation of glutamate receptor signaling pathway (GO:1900449)4.23255185
16cilium movement (GO:0003341)4.22357188
17regulation of synaptic vesicle transport (GO:1902803)4.19175135
18neurotransmitter-gated ion channel clustering (GO:0072578)4.15752645
19regulation of type B pancreatic cell apoptotic process (GO:2000674)4.09722742
20epithelial cilium movement (GO:0003351)4.05094458
21cilium or flagellum-dependent cell motility (GO:0001539)4.04414268
22neuron cell-cell adhesion (GO:0007158)4.03573983
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.01933079
24protein localization to synapse (GO:0035418)3.96800301
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.91831214
26gamma-aminobutyric acid transport (GO:0015812)3.90895041
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82557996
28axoneme assembly (GO:0035082)3.82435966
29neuron-neuron synaptic transmission (GO:0007270)3.81726701
30regulation of neuronal synaptic plasticity (GO:0048168)3.79972227
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.78656463
32regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.76123556
33synaptic transmission, glutamatergic (GO:0035249)3.74040565
34regulation of hexokinase activity (GO:1903299)3.71650951
35regulation of glucokinase activity (GO:0033131)3.71650951
36exploration behavior (GO:0035640)3.68858389
37regulation of synapse structural plasticity (GO:0051823)3.68703899
38negative regulation of hormone biosynthetic process (GO:0032353)3.67815505
39cellular potassium ion homeostasis (GO:0030007)3.62505978
40neurotransmitter transport (GO:0006836)3.57254342
41proline transport (GO:0015824)3.56724212
42glutamate receptor signaling pathway (GO:0007215)3.53185702
43neuromuscular process controlling posture (GO:0050884)3.49438580
44long-term synaptic potentiation (GO:0060291)3.48711717
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45662640
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44654702
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44608473
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.42675258
49activation of protein kinase A activity (GO:0034199)3.42071783
50long-term memory (GO:0007616)3.40549465
51positive regulation of membrane potential (GO:0045838)3.40033692
52cellular ketone body metabolic process (GO:0046950)3.39776810
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.39610024
54protein localization to cilium (GO:0061512)3.37636588
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.35632973
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34731039
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31430507
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.30909439
59regulation of neurotransmitter levels (GO:0001505)3.30653343
60regulation of cilium movement (GO:0003352)3.28477136
61water-soluble vitamin biosynthetic process (GO:0042364)3.26537042
62negative regulation of hormone metabolic process (GO:0032351)3.26067035
63negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.24438936
64righting reflex (GO:0060013)3.23207195
65endocrine pancreas development (GO:0031018)3.22743922
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21030256
67regulation of postsynaptic membrane potential (GO:0060078)3.20896589
68intraciliary transport (GO:0042073)3.20397832
69cerebellar Purkinje cell differentiation (GO:0021702)3.19707847
70sodium ion export (GO:0071436)3.18894675
71regulation of synaptic plasticity (GO:0048167)3.17567634
72presynaptic membrane assembly (GO:0097105)3.17429279
73insulin secretion (GO:0030073)3.17331186
74layer formation in cerebral cortex (GO:0021819)3.17266293
75regulation of neurotransmitter secretion (GO:0046928)3.15260069
76chemosensory behavior (GO:0007635)3.13659692
77positive regulation of glycolytic process (GO:0045821)3.12777352
78striatum development (GO:0021756)3.12251234
79nitric oxide mediated signal transduction (GO:0007263)3.10647138
80glandular epithelial cell differentiation (GO:0002067)3.10233654
81transmission of nerve impulse (GO:0019226)3.08713127
82glycine transport (GO:0015816)3.07532237
83positive regulation of neurotransmitter transport (GO:0051590)3.06013236
84response to histamine (GO:0034776)3.05278134
85regulation of neurotransmitter transport (GO:0051588)3.04855712
86prepulse inhibition (GO:0060134)3.04362162
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03534030
88response to auditory stimulus (GO:0010996)3.02898854
89ketone body metabolic process (GO:1902224)3.02774902
90synaptic vesicle endocytosis (GO:0048488)3.01358055
91regulation of vesicle fusion (GO:0031338)3.00707061
92membrane hyperpolarization (GO:0060081)3.00520950
93postsynaptic membrane organization (GO:0001941)3.00052566
94presynaptic membrane organization (GO:0097090)3.00008457
95positive regulation of synapse maturation (GO:0090129)2.99570777
96auditory behavior (GO:0031223)2.98520416
97behavioral response to cocaine (GO:0048148)2.97685053
98positive regulation of protein autophosphorylation (GO:0031954)2.95770928
99mating behavior (GO:0007617)2.93964974
100positive regulation of synaptic transmission (GO:0050806)2.93492202
101neuron recognition (GO:0008038)2.93068651
102positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91654768
103negative regulation of protein oligomerization (GO:0032460)2.90302399
104dendritic spine morphogenesis (GO:0060997)2.87868929
105neuromuscular process controlling balance (GO:0050885)2.86764397
106signal peptide processing (GO:0006465)2.85928872
107membrane depolarization during action potential (GO:0086010)2.85189620
108positive regulation of insulin secretion (GO:0032024)2.83941096
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83707884
110regulation of synaptic transmission, GABAergic (GO:0032228)2.83333470
111synaptic transmission (GO:0007268)2.82424666
112detection of calcium ion (GO:0005513)2.82311297
113synapse assembly (GO:0007416)2.81521612
114respiratory chain complex IV assembly (GO:0008535)2.81211794
115membrane depolarization (GO:0051899)2.80772034
116cerebellar granule cell differentiation (GO:0021707)2.80726363
117cell communication by electrical coupling (GO:0010644)2.79793403
118innervation (GO:0060384)2.79719888
119negative regulation of dendrite morphogenesis (GO:0050774)2.79503551
120startle response (GO:0001964)2.78616324
121regulation of synaptic transmission (GO:0050804)2.78238985
122long term synaptic depression (GO:0060292)2.77212977
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77122408
124regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.75675561
125regulation of dendritic spine morphogenesis (GO:0061001)2.75198385
126positive regulation of neurotransmitter secretion (GO:0001956)2.74628069
127learning (GO:0007612)2.73903579
128positive regulation of peptide hormone secretion (GO:0090277)2.73373298
129regulation of voltage-gated calcium channel activity (GO:1901385)2.73077460
130neuronal ion channel clustering (GO:0045161)2.72836400
131vesicle transport along microtubule (GO:0047496)2.70558055
132behavioral fear response (GO:0001662)2.70144900
133behavioral defense response (GO:0002209)2.70144900
134cerebellar Purkinje cell layer development (GO:0021680)2.70108935
135lactate metabolic process (GO:0006089)2.67933188
136regulation of insulin secretion (GO:0050796)2.65610473
137cilium organization (GO:0044782)2.65220743
138positive regulation of peptide secretion (GO:0002793)2.65192900
139inositol phosphate catabolic process (GO:0071545)2.64653010
140cytochrome complex assembly (GO:0017004)2.61793956
141retinal cone cell development (GO:0046549)2.61172193
142cilium assembly (GO:0042384)2.60846587
143negative regulation of JUN kinase activity (GO:0043508)2.57119904
144xenobiotic catabolic process (GO:0042178)2.52121004
145dopamine transport (GO:0015872)2.50804880
146regulation of calcium ion-dependent exocytosis (GO:0017158)2.49932323
147epithelial cell fate commitment (GO:0072148)2.48083734
148motile cilium assembly (GO:0044458)2.46764819
149inositol phosphate dephosphorylation (GO:0046855)2.45235684
150phosphorylated carbohydrate dephosphorylation (GO:0046838)2.45235684
151retinol metabolic process (GO:0042572)2.45036743
152branched-chain amino acid catabolic process (GO:0009083)2.44824558
153L-phenylalanine catabolic process (GO:0006559)2.43633632
154erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.43633632
155regulation of peptide hormone secretion (GO:0090276)2.43416522
156peptidyl-cysteine modification (GO:0018198)2.42898108
157positive regulation of macroautophagy (GO:0016239)2.42749919
158negative regulation of neurological system process (GO:0031645)2.42532637
159brain morphogenesis (GO:0048854)2.41824606
160phenylpropanoid metabolic process (GO:0009698)2.41387360
161regulation of peptide secretion (GO:0002791)2.38353495
162regulation of autophagic vacuole assembly (GO:2000785)2.33806532
163ferric iron transport (GO:0015682)2.33526638
164trivalent inorganic cation transport (GO:0072512)2.33526638
165metanephric nephron tubule development (GO:0072234)2.33417953
166metanephric tubule development (GO:0072170)2.33417953
167magnesium ion transport (GO:0015693)2.33276439
168mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33178129
169negative regulation of dendrite development (GO:2000171)2.32356392
170L-phenylalanine metabolic process (GO:0006558)2.32292084
171erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.32292084
172prostate gland growth (GO:0060736)2.31093496
173protein prenylation (GO:0018342)2.30962836
174prenylation (GO:0097354)2.30962836
175thyroid hormone metabolic process (GO:0042403)2.30280129
176positive regulation of vasodilation (GO:0045909)2.29126534
177potassium ion homeostasis (GO:0055075)2.28298333
178succinate metabolic process (GO:0006105)2.26755971
179peptide hormone secretion (GO:0030072)2.26503905
180glycerophospholipid catabolic process (GO:0046475)2.24003440
181positive regulation of meiosis (GO:0045836)2.23958383
182protein complex biogenesis (GO:0070271)2.23942552
183cellular component assembly involved in morphogenesis (GO:0010927)2.23803112
184regulation of microtubule-based movement (GO:0060632)2.22955286
185inositol phosphate-mediated signaling (GO:0048016)2.22468174
186peptide secretion (GO:0002790)2.21321446
187glutathione derivative biosynthetic process (GO:1901687)2.20847873
188glutathione derivative metabolic process (GO:1901685)2.20847873
189nonmotile primary cilium assembly (GO:0035058)2.20807798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.86069520
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.87245664
3GBX2_23144817_ChIP-Seq_PC3_Human3.80876483
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03248605
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95340830
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69862041
7REST_21632747_ChIP-Seq_MESCs_Mouse2.58310141
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48791667
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48791667
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48136096
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47071977
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44786365
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43440416
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.42456801
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40915340
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36770845
17DROSHA_22980978_ChIP-Seq_HELA_Human2.33811580
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.24397482
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.20226977
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14268437
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.10494122
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08255753
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.06683138
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.94549224
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.93152211
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92093475
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90935153
28VDR_22108803_ChIP-Seq_LS180_Human1.89475727
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88629923
30TAF15_26573619_Chip-Seq_HEK293_Human1.84809186
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81578334
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81568768
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80365214
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79325864
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76391292
36AR_21572438_ChIP-Seq_LNCaP_Human1.76196016
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.71474057
38SMAD4_21799915_ChIP-Seq_A2780_Human1.71030500
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66857884
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60875997
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57895226
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52904404
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50458026
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50319872
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50308634
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45022062
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44490417
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42467664
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.42364478
50P300_19829295_ChIP-Seq_ESCs_Human1.39707888
51FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38717927
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38647531
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38368929
54TCF4_22108803_ChIP-Seq_LS180_Human1.37755597
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.37425025
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37414261
57P53_22387025_ChIP-Seq_ESCs_Mouse1.37215984
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37202139
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.36413495
60EWS_26573619_Chip-Seq_HEK293_Human1.36295766
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35688117
62ZNF274_21170338_ChIP-Seq_K562_Hela1.34057560
63STAT3_23295773_ChIP-Seq_U87_Human1.30562556
64HTT_18923047_ChIP-ChIP_STHdh_Human1.30332812
65AR_25329375_ChIP-Seq_VCAP_Human1.30272946
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29000109
67CDX2_22108803_ChIP-Seq_LS180_Human1.28935551
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28061228
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26958092
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.26293202
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.25914804
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.25744449
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.25679227
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24986194
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.24489907
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.23467542
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23117644
78SOX2_18555785_Chip-Seq_ESCs_Mouse1.22623347
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.22441758
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20834583
81CBP_20019798_ChIP-Seq_JUKART_Human1.19163011
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19163011
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19008819
84* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18962588
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18871359
86P300_18555785_Chip-Seq_ESCs_Mouse1.18358700
87AR_19668381_ChIP-Seq_PC3_Human1.18293737
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17274100
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17113735
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16947271
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.15380593
92NANOG_19829295_ChIP-Seq_ESCs_Human1.15130194
93SOX2_19829295_ChIP-Seq_ESCs_Human1.15130194
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14570894
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13914194
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13811132
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13438129
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12628582
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.12375820
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.12286774
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12025360
102TCF4_23295773_ChIP-Seq_U87_Human1.11811658
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11188538
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11014423
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.10978803
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08943465
107AHR_22903824_ChIP-Seq_MCF-7_Human1.08354778
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08262989
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07134558
110PHF8_20622853_ChIP-Seq_HELA_Human1.07066377
111CTCF_18555785_Chip-Seq_ESCs_Mouse1.05323353
112IGF1R_20145208_ChIP-Seq_DFB_Human1.04910881
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04889526
114FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.04101095
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.03965650
116TBL1_22424771_ChIP-Seq_293T_Human1.03889301
117* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03822116
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.03661646
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.03125829
120YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02874587
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02611466
122FOXA1_25552417_ChIP-Seq_VCAP_Human1.01829239
123TP53_22573176_ChIP-Seq_HFKS_Human1.00829249
124* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00756815
125* FOXA1_25329375_ChIP-Seq_VCAP_Human1.00756815
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00032238
127* RUNX2_22187159_ChIP-Seq_PCA_Human0.99338550
128RNF2_27304074_Chip-Seq_NSC_Mouse0.98911545
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96138188
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.94523493
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.93963635
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93893145
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93049569
134ER_23166858_ChIP-Seq_MCF-7_Human0.92574501
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91067768
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.90005840
137BCAT_22108803_ChIP-Seq_LS180_Human0.87573185
138RING1B_27294783_Chip-Seq_NPCs_Mouse0.87244746
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.87229900
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87215182
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85344739
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85286899
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85145902
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.84588991
145EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84476080
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84302427
147FLI1_21867929_ChIP-Seq_TH2_Mouse0.83998688
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.83445992
149FUS_26573619_Chip-Seq_HEK293_Human0.83426199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.53216156
2MP0003880_abnormal_central_pattern4.17544593
3MP0003635_abnormal_synaptic_transmissio3.86332588
4MP0002822_catalepsy3.47335149
5MP0004270_analgesia3.40280977
6MP0009745_abnormal_behavioral_response3.27222276
7MP0009046_muscle_twitch3.14289302
8MP0002064_seizures3.12175424
9MP0002063_abnormal_learning/memory/cond3.06906821
10MP0010234_abnormal_vibrissa_follicle2.85710373
11MP0002572_abnormal_emotion/affect_behav2.67863735
12MP0002272_abnormal_nervous_system2.62421584
13MP0001968_abnormal_touch/_nociception2.60535395
14MP0009780_abnormal_chondrocyte_physiolo2.57205039
15MP0001486_abnormal_startle_reflex2.46525966
16MP0002734_abnormal_mechanical_nocicepti2.46386759
17MP0008877_abnormal_DNA_methylation2.38686715
18MP0001501_abnormal_sleep_pattern2.38169499
19MP0002909_abnormal_adrenal_gland2.29527644
20MP0005423_abnormal_somatic_nervous2.27987667
21MP0005646_abnormal_pituitary_gland2.17856824
22MP0002163_abnormal_gland_morphology2.08196401
23MP0003011_delayed_dark_adaptation2.04900856
24MP0002736_abnormal_nociception_after2.04164459
25MP0005220_abnormal_exocrine_pancreas2.03247481
26MP0002067_abnormal_sensory_capabilities1.92933512
27MP0001440_abnormal_grooming_behavior1.90171962
28MP0003329_amyloid_beta_deposits1.88876685
29MP0002733_abnormal_thermal_nociception1.88828720
30MP0002735_abnormal_chemical_nociception1.86648882
31MP0008569_lethality_at_weaning1.84827569
32MP0001944_abnormal_pancreas_morphology1.84103225
33MP0001970_abnormal_pain_threshold1.83686063
34MP0004043_abnormal_pH_regulation1.78011702
35MP0004924_abnormal_behavior1.72042963
36MP0005386_behavior/neurological_phenoty1.72042963
37MP0010678_abnormal_skin_adnexa1.70736898
38MP0000013_abnormal_adipose_tissue1.67809754
39MP0008875_abnormal_xenobiotic_pharmacok1.66347683
40MP0002557_abnormal_social/conspecific_i1.65391618
41MP0001984_abnormal_olfaction1.62787223
42MP0003879_abnormal_hair_cell1.61203320
43MP0003123_paternal_imprinting1.59420069
44MP0002693_abnormal_pancreas_physiology1.58484911
45MP0004885_abnormal_endolymph1.52992271
46MP0001529_abnormal_vocalization1.52844300
47MP0004811_abnormal_neuron_physiology1.52188444
48MP0002277_abnormal_respiratory_mucosa1.49524618
49MP0002184_abnormal_innervation1.48388959
50MP0004858_abnormal_nervous_system1.47479509
51MP0000427_abnormal_hair_cycle1.42217896
52MP0006276_abnormal_autonomic_nervous1.41745624
53MP0000955_abnormal_spinal_cord1.39394638
54MP0003633_abnormal_nervous_system1.38676626
55MP0005645_abnormal_hypothalamus_physiol1.38281163
56MP0010386_abnormal_urinary_bladder1.37672500
57MP0001502_abnormal_circadian_rhythm1.37476813
58MP0005551_abnormal_eye_electrophysiolog1.37251679
59MP0002254_reproductive_system_inflammat1.36915367
60MP0004019_abnormal_vitamin_homeostasis1.36380802
61MP0002066_abnormal_motor_capabilities/c1.36340568
62MP0002837_dystrophic_cardiac_calcinosis1.36189799
63MP0003787_abnormal_imprinting1.36129105
64MP0000383_abnormal_hair_follicle1.30962970
65MP0001756_abnormal_urination1.30718952
66MP0002928_abnormal_bile_duct1.30645270
67MP0002882_abnormal_neuron_morphology1.29636891
68MP0003122_maternal_imprinting1.29610356
69MP0000778_abnormal_nervous_system1.29476446
70MP0002876_abnormal_thyroid_physiology1.27562757
71MP0004142_abnormal_muscle_tone1.26631428
72MP0001905_abnormal_dopamine_level1.25828947
73MP0006036_abnormal_mitochondrial_physio1.21076623
74MP0003283_abnormal_digestive_organ1.20121249
75MP0004133_heterotaxia1.18755095
76MP0002229_neurodegeneration1.17446481
77MP0003631_nervous_system_phenotype1.14746804
78MP0005332_abnormal_amino_acid1.10887782
79MP0003121_genomic_imprinting1.10273398
80MP0005535_abnormal_body_temperature1.09223978
81MP0002090_abnormal_vision1.06779640
82MP0005365_abnormal_bile_salt1.05632850
83MP0003690_abnormal_glial_cell1.03811746
84MP0002069_abnormal_eating/drinking_beha1.02032225
85MP0005636_abnormal_mineral_homeostasis1.00900230
86MP0002102_abnormal_ear_morphology1.00270493
87MP0006035_abnormal_mitochondrial_morpho0.98177627
88MP0003183_abnormal_peptide_metabolism0.97930597
89MP0008872_abnormal_physiological_respon0.97589235
90MP0003634_abnormal_glial_cell0.94199293
91MP0010329_abnormal_lipoprotein_level0.92781425
92MP0001177_atelectasis0.92209494
93MP0004147_increased_porphyrin_level0.89558763
94MP0005084_abnormal_gallbladder_morpholo0.89464328
95MP0000516_abnormal_urinary_system0.89363996
96MP0005367_renal/urinary_system_phenotyp0.89363996
97MP0002152_abnormal_brain_morphology0.89048441
98MP0000751_myopathy0.88591043
99MP0002160_abnormal_reproductive_system0.87976117
100MP0001188_hyperpigmentation0.87306663
101MP0004085_abnormal_heartbeat0.86146006
102MP0000604_amyloidosis0.85588782
103MP0006072_abnormal_retinal_apoptosis0.84683204
104MP0003632_abnormal_nervous_system0.84066010
105MP0000538_abnormal_urinary_bladder0.83825009
106MP0000920_abnormal_myelination0.83212488
107MP0008874_decreased_physiological_sensi0.82751389
108MP0001664_abnormal_digestion0.82639262
109MP0008961_abnormal_basal_metabolism0.82080902
110MP0004145_abnormal_muscle_electrophysio0.81208688
111MP0001963_abnormal_hearing_physiology0.79885724
112MP0000631_abnormal_neuroendocrine_gland0.77861876
113MP0002638_abnormal_pupillary_reflex0.76928867
114MP0003075_altered_response_to0.76876766
115MP0000462_abnormal_digestive_system0.74829723
116MP0001765_abnormal_ion_homeostasis0.74680192
117MP0004742_abnormal_vestibular_system0.74192507
118MP0003252_abnormal_bile_duct0.72949536
119MP0003172_abnormal_lysosome_physiology0.72400913
120MP0002168_other_aberrant_phenotype0.70738338
121MP0004215_abnormal_myocardial_fiber0.70633672
122MP0000639_abnormal_adrenal_gland0.70249128
123MP0004233_abnormal_muscle_weight0.70185121
124MP0005085_abnormal_gallbladder_physiolo0.68210869
125MP0002752_abnormal_somatic_nervous0.66522489
126MP0005253_abnormal_eye_physiology0.65735968
127MP0004130_abnormal_muscle_cell0.63081910
128MP0002078_abnormal_glucose_homeostasis0.61691445
129MP0001299_abnormal_eye_distance/0.61683073
130MP0001485_abnormal_pinna_reflex0.61081662
131MP0003195_calcinosis0.59884742
132MP0001986_abnormal_taste_sensitivity0.59190149
133MP0005379_endocrine/exocrine_gland_phen0.58456014
134MP0003953_abnormal_hormone_level0.57462268
135MP0000003_abnormal_adipose_tissue0.56775944
136MP0005394_taste/olfaction_phenotype0.56680984
137MP0005499_abnormal_olfactory_system0.56680984

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.21926414
2Myokymia (HP:0002411)5.76880912
3Focal seizures (HP:0007359)5.02320120
4Atonic seizures (HP:0010819)4.88636607
5Visual hallucinations (HP:0002367)4.70403410
6Epileptic encephalopathy (HP:0200134)4.65399533
7Febrile seizures (HP:0002373)4.13142340
8Absence seizures (HP:0002121)4.04971636
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.99245997
10Progressive cerebellar ataxia (HP:0002073)3.82402023
11Hyperinsulinemic hypoglycemia (HP:0000825)3.81929162
12Abnormal respiratory epithelium morphology (HP:0012253)3.73107569
13Abnormal respiratory motile cilium morphology (HP:0005938)3.73107569
14Generalized tonic-clonic seizures (HP:0002069)3.68214966
15Dialeptic seizures (HP:0011146)3.66325004
16Hypoglycemic seizures (HP:0002173)3.64599369
17Action tremor (HP:0002345)3.59649052
18Rhinitis (HP:0012384)3.56406809
19Abnormal respiratory motile cilium physiology (HP:0012261)3.56212027
20Abnormal ciliary motility (HP:0012262)3.49995423
21Hyperventilation (HP:0002883)3.40430118
22Absent/shortened dynein arms (HP:0200106)3.37110553
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.37110553
24Ketoacidosis (HP:0001993)3.33844976
25Hypoglycemic coma (HP:0001325)3.20970834
26Ankle clonus (HP:0011448)3.20008341
27Supranuclear gaze palsy (HP:0000605)3.19075347
28Depression (HP:0000716)3.14884277
29Pheochromocytoma (HP:0002666)3.13258664
30Dysdiadochokinesis (HP:0002075)3.13180959
31Abnormal eating behavior (HP:0100738)3.13091622
32Gaze-evoked nystagmus (HP:0000640)3.09758151
33Broad-based gait (HP:0002136)3.09092301
34Anxiety (HP:0000739)3.06157331
35Truncal ataxia (HP:0002078)3.04525019
36Hypothermia (HP:0002045)3.02810673
37Poor eye contact (HP:0000817)3.01820048
38Chronic bronchitis (HP:0004469)2.97240423
39Hyperglycemia (HP:0003074)2.96384843
40Impaired vibration sensation in the lower limbs (HP:0002166)2.95628354
41Impaired social interactions (HP:0000735)2.90261448
42Abnormal social behavior (HP:0012433)2.90261448
43Dysmetria (HP:0001310)2.81486793
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.80691972
45Bronchiectasis (HP:0002110)2.78033607
46Postural instability (HP:0002172)2.76492549
47Scanning speech (HP:0002168)2.76041841
48Neuroendocrine neoplasm (HP:0100634)2.75229763
49Neurofibrillary tangles (HP:0002185)2.73762384
50Epileptiform EEG discharges (HP:0011182)2.73218120
51Torticollis (HP:0000473)2.67298988
52Urinary bladder sphincter dysfunction (HP:0002839)2.65940370
53Methylmalonic acidemia (HP:0002912)2.63686363
54EEG with generalized epileptiform discharges (HP:0011198)2.63388931
55Abnormality of aromatic amino acid family metabolism (HP:0004338)2.58962662
56Large for gestational age (HP:0001520)2.57581917
57Hypomagnesemia (HP:0002917)2.57305763
58Calf muscle hypertrophy (HP:0008981)2.56603691
59Resting tremor (HP:0002322)2.53060564
60Hypsarrhythmia (HP:0002521)2.51944004
61Cerebral inclusion bodies (HP:0100314)2.51828948
62Intention tremor (HP:0002080)2.47319621
63Focal dystonia (HP:0004373)2.46910737
64Spastic gait (HP:0002064)2.45291779
65Abnormality of binocular vision (HP:0011514)2.45017098
66Diplopia (HP:0000651)2.45017098
67Bradykinesia (HP:0002067)2.44584573
68Dysmetric saccades (HP:0000641)2.44109315
69Polyphagia (HP:0002591)2.42762382
70Limb dystonia (HP:0002451)2.42137922
71Pancreatic fibrosis (HP:0100732)2.41861573
72Impaired smooth pursuit (HP:0007772)2.41483974
73Abnormal pancreas size (HP:0012094)2.40316042
74Excessive salivation (HP:0003781)2.39887860
75Drooling (HP:0002307)2.39887860
76Insulin-resistant diabetes mellitus (HP:0000831)2.39726999
77Pancreatic cysts (HP:0001737)2.38042617
78Progressive macrocephaly (HP:0004481)2.36572730
79Progressive inability to walk (HP:0002505)2.35117708
80Abnormality of midbrain morphology (HP:0002418)2.34124969
81Molar tooth sign on MRI (HP:0002419)2.34124969
82Abnormality of endocrine pancreas physiology (HP:0012093)2.33929051
83Abnormality of the pancreatic islet cells (HP:0006476)2.33929051
84Hemiplegia (HP:0002301)2.32836020
85True hermaphroditism (HP:0010459)2.32622261
86Muscle hypertrophy of the lower extremities (HP:0008968)2.31699563
87Mutism (HP:0002300)2.31656682
88Agitation (HP:0000713)2.31449958
89Hemiparesis (HP:0001269)2.30922033
90Amblyopia (HP:0000646)2.30495292
91Craniofacial dystonia (HP:0012179)2.29251089
92Urinary urgency (HP:0000012)2.28157785
93Status epilepticus (HP:0002133)2.26091237
94Genetic anticipation (HP:0003743)2.24374755
95Papilledema (HP:0001085)2.23245571
96Nephronophthisis (HP:0000090)2.20413174
97Abnormality of vitamin B metabolism (HP:0004340)2.18237008
98Abnormality of the renal cortex (HP:0011035)2.17956868
99Abnormality of vitamin metabolism (HP:0100508)2.17604740
100Central scotoma (HP:0000603)2.16978883
101Hyperactive renin-angiotensin system (HP:0000841)2.16090631
102Gait imbalance (HP:0002141)2.15164538
103Ketosis (HP:0001946)2.15063820
104Enlarged penis (HP:0000040)2.14916779
105Abnormality of the corticospinal tract (HP:0002492)2.13627523
106Blue irides (HP:0000635)2.13214535
107Impaired vibratory sensation (HP:0002495)2.12832449
108Termporal pattern (HP:0011008)2.12719919
109Insidious onset (HP:0003587)2.12719919
110Abnormality of ocular smooth pursuit (HP:0000617)2.12519857
111Postural tremor (HP:0002174)2.11784961
112Symptomatic seizures (HP:0011145)2.11705123
113Neuronal loss in central nervous system (HP:0002529)2.11291340
114Hyperaldosteronism (HP:0000859)2.09895991
115Acute necrotizing encephalopathy (HP:0006965)2.09872344
116Failure to thrive in infancy (HP:0001531)2.09201534
117Lower limb muscle weakness (HP:0007340)2.04981384
118Neoplasm of the adrenal gland (HP:0100631)2.04765386
119Abnormality of the renal medulla (HP:0100957)2.04126722
120Abnormality of chloride homeostasis (HP:0011422)2.03153720
121Increased circulating renin level (HP:0000848)2.03109545
122Genital tract atresia (HP:0001827)2.02936615
123Gait ataxia (HP:0002066)2.01903322
124Fetal akinesia sequence (HP:0001989)2.01544866
125Abnormality of the lower motor neuron (HP:0002366)2.01069478
126Tongue fasciculations (HP:0001308)2.00765010
127Furrowed tongue (HP:0000221)2.00363868
128Ventricular fibrillation (HP:0001663)2.00258926
129Hyperkalemia (HP:0002153)2.00191662
130Infertility (HP:0000789)1.99535657
131Conjunctival hamartoma (HP:0100780)1.99050089
132Vaginal atresia (HP:0000148)1.98766376
133Generalized myoclonic seizures (HP:0002123)1.98732351
134Abnormality of renin-angiotensin system (HP:0000847)1.97640857
135Stereotypic behavior (HP:0000733)1.97220573
136Renal salt wasting (HP:0000127)1.97014996
137Rigidity (HP:0002063)1.96126214
138Absent speech (HP:0001344)1.96101456
139Clonus (HP:0002169)1.95583903
140Polydipsia (HP:0001959)1.95047088
141Abnormal drinking behavior (HP:0030082)1.95047088
142Megalencephaly (HP:0001355)1.93666834
143Aplasia/hypoplasia of the uterus (HP:0008684)1.89974400
144Psychosis (HP:0000709)1.89621661
145Male infertility (HP:0003251)1.88748251
146Hypokinesia (HP:0002375)1.88669344
147Tubulointerstitial nephritis (HP:0001970)1.87757599
148Methylmalonic aciduria (HP:0012120)1.87113338
149Abnormality of magnesium homeostasis (HP:0004921)1.87093074
150Congenital primary aphakia (HP:0007707)1.85718850
151Oligomenorrhea (HP:0000876)1.85607555
152Testicular neoplasm (HP:0010788)1.85321088
153Neoplasm of the peripheral nervous system (HP:0100007)1.85087579
154Double outlet right ventricle (HP:0001719)1.84502828
155Congenital malformation of the right heart (HP:0011723)1.84502828
156Abnormality of saccadic eye movements (HP:0000570)1.82946719
157Inability to walk (HP:0002540)1.82801977
158Acute encephalopathy (HP:0006846)1.81341574
159Specific learning disability (HP:0001328)1.80814458
160Unilateral renal agenesis (HP:0000122)1.80448275
161Muscular hypotonia of the trunk (HP:0008936)1.80107427
162Abnormal mitochondria in muscle tissue (HP:0008316)1.79352405
163Male pseudohermaphroditism (HP:0000037)1.78108284
164Decreased circulating renin level (HP:0003351)1.77371375
165Goiter (HP:0000853)1.77155787
166Abnormality of calcium-phosphate metabolism (HP:0100530)1.76054221
167Nephrogenic diabetes insipidus (HP:0009806)1.75971649
168Renal Fanconi syndrome (HP:0001994)1.75485291
169Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70855380
170Degeneration of the lateral corticospinal tracts (HP:0002314)1.70855380
171Hypoventilation (HP:0002791)1.70329788
172Medial flaring of the eyebrow (HP:0010747)1.69755847
173Incomplete penetrance (HP:0003829)1.69241582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.27342538
2EPHA43.76055223
3MST43.55849384
4MAP3K43.13136256
5MAP3K93.09380358
6CASK2.77151536
7MAP2K72.64940484
8DAPK22.40722842
9MAP4K22.38804476
10MARK12.37706679
11MINK12.26532820
12MAP3K122.23280927
13STK38L2.05801636
14PRKD31.99731192
15MAP2K41.96284696
16NTRK11.94461835
17NTRK21.89540301
18GRK11.85037917
19PAK61.84779963
20CAMKK11.77315131
21KSR21.74854297
22CAMKK21.67434013
23ACVR1B1.65404851
24OXSR11.54789968
25CDK191.53348342
26CDK51.49973404
27PASK1.49810693
28INSRR1.47047297
29DAPK11.46115962
30FGFR31.43108018
31BMPR1B1.41807413
32TAF11.38889229
33TRPM71.37791414
34MAP3K21.37108978
35GRK51.34634536
36PLK21.32684422
37SGK4941.31707412
38SGK2231.31707412
39PRPF4B1.29598689
40RIPK41.26210111
41AKT31.22561627
42PRKCG1.21436152
43ARAF1.20887291
44TNIK1.19396242
45STK381.18167513
46PRKCH1.16311621
47KSR11.16137305
48STK241.14658772
49OBSCN1.14195088
50ERBB31.14042849
51ADRBK21.13923549
52UHMK11.13853134
53NLK1.12824522
54MAPK151.10087158
55MAPK131.08912132
56BRSK21.06819789
57SGK21.04308809
58EPHA21.04225142
59CSNK1G11.03463916
60PINK11.03277823
61PHKG11.02686020
62PHKG21.02686020
63CAMK2A1.02034242
64WNK31.01668657
65TSSK60.95795243
66CAMK2B0.94080387
67LMTK20.90464113
68SGK30.89826325
69FES0.88200556
70WNK40.87429551
71RET0.82614208
72EIF2AK30.82230232
73MAP3K130.80104079
74CAMK10.79912501
75CSNK1G30.79756296
76PRKCE0.79228292
77PAK30.78985909
78PRKAA20.77436808
79CDK180.76306585
80WNK10.75173177
81PRKCI0.75114843
82MAPKAPK30.74890075
83CDK140.74726251
84PNCK0.74592013
85CDK150.73546443
86MAP3K10.71696780
87SIK20.71640125
88NUAK10.71323106
89MAP2K60.71287069
90SGK10.70603937
91STK110.70288364
92STK390.70267053
93PDK30.70211116
94PDK40.70211116
95TYRO30.69187732
96CSNK1G20.65886081
97FER0.65813012
98PDPK10.65656174
99CAMK2D0.65316654
100MKNK20.65291861
101PRKG20.62697733
102NEK60.61880404
103CDC42BPA0.61870296
104PRKAA10.61499332
105CAMK2G0.61215472
106PDK10.60866949
107CDK11A0.60375507
108TNK20.60293267
109PLK30.59244438
110PTK2B0.58855115
111TRIM280.58422124
112MARK20.57583887
113FRK0.56783846
114DYRK1A0.56742159
115BMPR20.56386935
116NEK10.53753787
117CCNB10.53364201
118TAOK10.51748668
119HIPK20.51399084
120STK30.50682861
121RPS6KA30.50303051
122BCR0.50293383
123CAMK1G0.49383879
124MAP2K10.48923805
125PRKG10.48918162
126PRKCZ0.47450923
127PRKACA0.46581459
128ZAK0.45376943
129CSNK1A10.44919709
130CSNK1A1L0.44566119
131SCYL20.44556335
132MAPKAPK50.44519492
133FGFR20.42441499
134CDK30.42391373
135PRKCA0.41401877
136RAF10.40887071
137STK160.40710055
138MYLK0.40645976
139NME10.40571947
140BRAF0.40087616
141FYN0.40012173
142MUSK0.39888931
143PDK20.38663180
144ROCK10.36222250
145LIMK10.33537940
146MAP3K70.32301415
147PRKCQ0.28157685
148CSNK1E0.27698571

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.56093678
2Nicotine addiction_Homo sapiens_hsa050333.41152600
3GABAergic synapse_Homo sapiens_hsa047272.78300041
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53778211
5Protein export_Homo sapiens_hsa030602.51973293
6Circadian entrainment_Homo sapiens_hsa047132.44858952
7Morphine addiction_Homo sapiens_hsa050322.44463834
8Olfactory transduction_Homo sapiens_hsa047402.44110063
9Vitamin B6 metabolism_Homo sapiens_hsa007502.40676533
10Amphetamine addiction_Homo sapiens_hsa050312.26667784
11Collecting duct acid secretion_Homo sapiens_hsa049662.25492117
12Glutamatergic synapse_Homo sapiens_hsa047242.22094225
13Long-term potentiation_Homo sapiens_hsa047202.22047004
14Insulin secretion_Homo sapiens_hsa049112.20322248
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18185498
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10798587
17Dopaminergic synapse_Homo sapiens_hsa047282.03981304
18Salivary secretion_Homo sapiens_hsa049701.94260115
19Cocaine addiction_Homo sapiens_hsa050301.78645208
20Taste transduction_Homo sapiens_hsa047421.76254937
21Propanoate metabolism_Homo sapiens_hsa006401.75512899
22Gastric acid secretion_Homo sapiens_hsa049711.69513319
23Cholinergic synapse_Homo sapiens_hsa047251.69486508
24Vibrio cholerae infection_Homo sapiens_hsa051101.61153952
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60385506
26beta-Alanine metabolism_Homo sapiens_hsa004101.59102285
27Serotonergic synapse_Homo sapiens_hsa047261.57718491
28Renin secretion_Homo sapiens_hsa049241.56825259
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52180530
30Regulation of autophagy_Homo sapiens_hsa041401.48138559
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47859479
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47571153
33Long-term depression_Homo sapiens_hsa047301.44789795
34Fatty acid elongation_Homo sapiens_hsa000621.40117228
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40027518
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38485673
37Peroxisome_Homo sapiens_hsa041461.37032509
38Calcium signaling pathway_Homo sapiens_hsa040201.35823791
39Oxytocin signaling pathway_Homo sapiens_hsa049211.29476662
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27330989
41Tryptophan metabolism_Homo sapiens_hsa003801.24434644
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23156288
43Type II diabetes mellitus_Homo sapiens_hsa049301.20831578
44Nitrogen metabolism_Homo sapiens_hsa009101.20323722
45Phototransduction_Homo sapiens_hsa047441.15521956
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13437610
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.12850769
48cAMP signaling pathway_Homo sapiens_hsa040241.12071597
49Sphingolipid metabolism_Homo sapiens_hsa006001.11784884
50Folate biosynthesis_Homo sapiens_hsa007901.11680572
51Gap junction_Homo sapiens_hsa045401.10314910
52Histidine metabolism_Homo sapiens_hsa003401.09378735
53GnRH signaling pathway_Homo sapiens_hsa049121.08335506
54Parkinsons disease_Homo sapiens_hsa050121.05577682
55Fatty acid metabolism_Homo sapiens_hsa012121.04559776
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01215960
57Chemical carcinogenesis_Homo sapiens_hsa052041.01056290
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00794952
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00216661
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99375898
61Fatty acid degradation_Homo sapiens_hsa000710.99343400
62Mineral absorption_Homo sapiens_hsa049780.98949737
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98724223
64Huntingtons disease_Homo sapiens_hsa050160.98190784
65Caffeine metabolism_Homo sapiens_hsa002320.93865093
66Glutathione metabolism_Homo sapiens_hsa004800.92657760
67Ether lipid metabolism_Homo sapiens_hsa005650.92545407
68Estrogen signaling pathway_Homo sapiens_hsa049150.92167260
69Thyroid hormone synthesis_Homo sapiens_hsa049180.92101795
70Pancreatic secretion_Homo sapiens_hsa049720.91871758
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90854446
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90151692
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88593646
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88492596
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86812651
76Selenocompound metabolism_Homo sapiens_hsa004500.86555357
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.86008435
78Retinol metabolism_Homo sapiens_hsa008300.84759313
79ABC transporters_Homo sapiens_hsa020100.84497397
80Butanoate metabolism_Homo sapiens_hsa006500.82213582
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76812785
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75969460
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75446627
84Type I diabetes mellitus_Homo sapiens_hsa049400.75039808
85Glioma_Homo sapiens_hsa052140.74430351
86Cardiac muscle contraction_Homo sapiens_hsa042600.73361659
87ErbB signaling pathway_Homo sapiens_hsa040120.72961717
88Melanogenesis_Homo sapiens_hsa049160.72912039
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71023041
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70532352
91Phenylalanine metabolism_Homo sapiens_hsa003600.69201613
92Axon guidance_Homo sapiens_hsa043600.67825051
93Linoleic acid metabolism_Homo sapiens_hsa005910.64068329
94Glucagon signaling pathway_Homo sapiens_hsa049220.63051580
95Bile secretion_Homo sapiens_hsa049760.62972663
96Tyrosine metabolism_Homo sapiens_hsa003500.62680943
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62610650
98Circadian rhythm_Homo sapiens_hsa047100.62222912
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.60677909
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59814763
101Metabolic pathways_Homo sapiens_hsa011000.59188739
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.58802045
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.56978646
104Dorso-ventral axis formation_Homo sapiens_hsa043200.54719059
105Tight junction_Homo sapiens_hsa045300.54351152
106Dilated cardiomyopathy_Homo sapiens_hsa054140.53002093
107Sulfur metabolism_Homo sapiens_hsa009200.51284528
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50928210
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50588878
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50405922
111Inositol phosphate metabolism_Homo sapiens_hsa005620.49335289
112MAPK signaling pathway_Homo sapiens_hsa040100.47843232
113Choline metabolism in cancer_Homo sapiens_hsa052310.46068166
114mTOR signaling pathway_Homo sapiens_hsa041500.44780950
115Oxidative phosphorylation_Homo sapiens_hsa001900.43192388
116Prion diseases_Homo sapiens_hsa050200.43011869
117Ras signaling pathway_Homo sapiens_hsa040140.42754578
118Rheumatoid arthritis_Homo sapiens_hsa053230.42699590
119N-Glycan biosynthesis_Homo sapiens_hsa005100.41901807
120Alzheimers disease_Homo sapiens_hsa050100.40844635
121Oocyte meiosis_Homo sapiens_hsa041140.40824431
122Ovarian steroidogenesis_Homo sapiens_hsa049130.39368576
123Alcoholism_Homo sapiens_hsa050340.38012574
124Arginine biosynthesis_Homo sapiens_hsa002200.37284723
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35992906
126Endocytosis_Homo sapiens_hsa041440.35888914
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35713861
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35064663
129Insulin signaling pathway_Homo sapiens_hsa049100.34641400
130Pyruvate metabolism_Homo sapiens_hsa006200.34207026
131Rap1 signaling pathway_Homo sapiens_hsa040150.33549275
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32709315
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.32515818
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32468890
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32086872
136Lysosome_Homo sapiens_hsa041420.31359546
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31328893
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31307215
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.30373107
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30301105
141Fatty acid biosynthesis_Homo sapiens_hsa000610.29633333
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29419506

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