ENPP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.06383010
2myelination (GO:0042552)6.71832142
3axon ensheathment (GO:0008366)6.66053387
4ensheathment of neurons (GO:0007272)6.66053387
5response to methylmercury (GO:0051597)6.31478417
6L-amino acid import (GO:0043092)6.20383028
7long-chain fatty acid biosynthetic process (GO:0042759)6.01650321
8cholesterol biosynthetic process (GO:0006695)5.84839167
9amino acid import (GO:0043090)5.82140916
10regulation of collateral sprouting (GO:0048670)5.70654333
11activated T cell proliferation (GO:0050798)5.66461924
12response to redox state (GO:0051775)5.22681672
13sterol biosynthetic process (GO:0016126)5.16219872
14negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.56321249
15myelin maintenance (GO:0043217)4.52450089
16myelination in peripheral nervous system (GO:0022011)4.41219897
17peripheral nervous system axon ensheathment (GO:0032292)4.41219897
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.40494382
19isoprenoid biosynthetic process (GO:0008299)4.35717178
20negative regulation of neurotransmitter secretion (GO:0046929)4.34520399
21negative regulation of neurotransmitter transport (GO:0051589)4.33469325
22amyloid precursor protein metabolic process (GO:0042982)4.32170650
23long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.25885368
24substantia nigra development (GO:0021762)4.25093842
25neuron cell-cell adhesion (GO:0007158)4.20385882
26glycerophospholipid catabolic process (GO:0046475)4.09215107
27positive regulation of actin filament depolymerization (GO:0030836)4.09202650
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.07170255
29detection of light stimulus involved in sensory perception (GO:0050962)4.04908217
30detection of light stimulus involved in visual perception (GO:0050908)4.04908217
31import into cell (GO:0098657)4.01455199
32response to hepatocyte growth factor (GO:0035728)3.97851008
33cellular response to hepatocyte growth factor stimulus (GO:0035729)3.97851008
34negative regulation of protein localization to cell surface (GO:2000009)3.90940247
35photoreceptor cell differentiation (GO:0046530)3.89795233
36eye photoreceptor cell differentiation (GO:0001754)3.89795233
37fucose catabolic process (GO:0019317)3.85175120
38L-fucose metabolic process (GO:0042354)3.85175120
39L-fucose catabolic process (GO:0042355)3.85175120
40locomotory exploration behavior (GO:0035641)3.81781156
41creatine metabolic process (GO:0006600)3.78994720
42fatty-acyl-CoA biosynthetic process (GO:0046949)3.75770242
43behavioral response to nicotine (GO:0035095)3.72744208
44cellular response to epinephrine stimulus (GO:0071872)3.71243154
45very long-chain fatty acid metabolic process (GO:0000038)3.70167287
46negative regulation of axon extension (GO:0030517)3.65934349
47positive regulation of neurological system process (GO:0031646)3.65035762
48establishment of mitochondrion localization (GO:0051654)3.64458786
49positive regulation of oligodendrocyte differentiation (GO:0048714)3.59983264
50fatty-acyl-CoA metabolic process (GO:0035337)3.57831559
51response to lipoprotein particle (GO:0055094)3.57069705
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56039219
53L-glutamate transport (GO:0015813)3.55984896
54oligodendrocyte differentiation (GO:0048709)3.53880496
55C4-dicarboxylate transport (GO:0015740)3.47678392
56neuron remodeling (GO:0016322)3.44833253
57acidic amino acid transport (GO:0015800)3.43862569
58response to epinephrine (GO:0071871)3.42636526
59response to pheromone (GO:0019236)3.41871902
60regulation of lipoprotein metabolic process (GO:0050746)3.38749803
61postsynaptic membrane organization (GO:0001941)3.35461037
62gamma-aminobutyric acid transport (GO:0015812)3.34675067
63presynaptic membrane organization (GO:0097090)3.30540300
64glycosphingolipid biosynthetic process (GO:0006688)3.27791141
65negative regulation of axonogenesis (GO:0050771)3.22711894
66protein K11-linked deubiquitination (GO:0035871)3.22286766
67presynaptic membrane assembly (GO:0097105)3.21111101
68astrocyte differentiation (GO:0048708)3.20086265
69pyrimidine nucleobase catabolic process (GO:0006208)3.18481308
70astrocyte development (GO:0014002)3.16803483
71nucleotide transmembrane transport (GO:1901679)3.15456316
72protein palmitoylation (GO:0018345)3.13429642
73retinal cone cell development (GO:0046549)3.11366478
74neuronal action potential propagation (GO:0019227)3.10587726
75regulation of transmission of nerve impulse (GO:0051969)3.10585318
76acyl-CoA biosynthetic process (GO:0071616)3.10560795
77thioester biosynthetic process (GO:0035384)3.10560795
78indolalkylamine metabolic process (GO:0006586)3.08908153
79transmission of nerve impulse (GO:0019226)3.07519314
80negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06322052
81regulation of rhodopsin mediated signaling pathway (GO:0022400)3.05788210
82Rap protein signal transduction (GO:0032486)3.05637104
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.03869664
84DNA deamination (GO:0045006)3.03715468
85neuronal ion channel clustering (GO:0045161)3.02245836
86peripheral nervous system development (GO:0007422)3.00875814
87photoreceptor cell maintenance (GO:0045494)2.96223321
88limb bud formation (GO:0060174)2.95733480
89regulation of axon regeneration (GO:0048679)2.95483581
90regulation of neuron projection regeneration (GO:0070570)2.95483581
91rhodopsin mediated signaling pathway (GO:0016056)2.94889586
92asymmetric protein localization (GO:0008105)2.91651975
93water-soluble vitamin biosynthetic process (GO:0042364)2.89816404
94adaptation of signaling pathway (GO:0023058)2.88512763
95estrogen biosynthetic process (GO:0006703)2.87993113
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87402302
97negative regulation of axon extension involved in axon guidance (GO:0048843)2.87120057
98negative regulation of axon guidance (GO:1902668)2.86980876
99nucleobase catabolic process (GO:0046113)2.86460928
100amyloid precursor protein catabolic process (GO:0042987)2.84264113
101neural nucleus development (GO:0048857)2.82214742
102positive regulation of meiosis (GO:0045836)2.81220938
103regulation of phospholipid biosynthetic process (GO:0071071)2.81036626
104membrane depolarization during action potential (GO:0086010)2.80683001
105indole-containing compound catabolic process (GO:0042436)2.79345591
106indolalkylamine catabolic process (GO:0046218)2.79345591
107tryptophan catabolic process (GO:0006569)2.79345591
108enteric nervous system development (GO:0048484)2.77280085
109auditory receptor cell stereocilium organization (GO:0060088)2.76327703
110proline transport (GO:0015824)2.74956725
111negative regulation of telomere maintenance (GO:0032205)2.74138652
112axoneme assembly (GO:0035082)2.73433787
113mannosylation (GO:0097502)2.72830021
114cellular response to monoamine stimulus (GO:0071868)2.72129868
115cellular response to catecholamine stimulus (GO:0071870)2.72129868
116neuronal action potential (GO:0019228)2.71504675
117cerebral cortex radially oriented cell migration (GO:0021799)2.69898897
118protein polyglutamylation (GO:0018095)2.69389260
119startle response (GO:0001964)2.67798418
120cellular ketone body metabolic process (GO:0046950)2.67712286
121apical protein localization (GO:0045176)2.67086660
122semaphorin-plexin signaling pathway (GO:0071526)2.66983778
123photoreceptor cell development (GO:0042461)2.66738726
124regulation of cell proliferation involved in kidney development (GO:1901722)2.66144859
125neurotransmitter uptake (GO:0001504)2.65645534
126alcohol biosynthetic process (GO:0046165)2.63822913
127tryptophan metabolic process (GO:0006568)2.63564219
128indole-containing compound metabolic process (GO:0042430)2.63493712
129primary amino compound metabolic process (GO:1901160)2.63014796
130neuron recognition (GO:0008038)2.61725785
131reflex (GO:0060004)2.60908395
132negative regulation of Rho protein signal transduction (GO:0035024)2.60539883
133regulation of neurotransmitter uptake (GO:0051580)2.60337970
134negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60285609
135neural tube formation (GO:0001841)2.59770631
136negative regulation of myoblast differentiation (GO:0045662)2.59717621
137peptidyl-tyrosine autophosphorylation (GO:0038083)2.59663330
138protein neddylation (GO:0045116)2.58743634
139appendage development (GO:0048736)2.58127930
140limb development (GO:0060173)2.58127930
141response to catecholamine (GO:0071869)2.57862156
142response to monoamine (GO:0071867)2.57862156
143positive regulation of meiotic cell cycle (GO:0051446)2.57851741
144piRNA metabolic process (GO:0034587)2.55444811
145detection of temperature stimulus involved in sensory perception (GO:0050961)2.53432737
146detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.53432737
147protein import into peroxisome matrix (GO:0016558)2.53320736
148membrane tubulation (GO:0097320)2.51761898
149axon development (GO:0061564)2.51480269
150kynurenine metabolic process (GO:0070189)2.51335191
151regulation of action potential (GO:0098900)2.51082643
152positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.50858714
153axonal fasciculation (GO:0007413)2.50507231
154generation of neurons (GO:0048699)2.50416150
155positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50359037
156somite development (GO:0061053)2.50075041
157positive regulation of catenin import into nucleus (GO:0035413)2.49391501
158dermatan sulfate biosynthetic process (GO:0030208)2.47589159
159negative regulation of reactive oxygen species metabolic process (GO:2000378)2.47448949
160eye photoreceptor cell development (GO:0042462)2.47433325
161regulation of cilium movement (GO:0003352)2.46874178
162regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.46250394
163nonmotile primary cilium assembly (GO:0035058)2.45449938
164ketone body metabolic process (GO:1902224)2.44954798
165cilium morphogenesis (GO:0060271)2.43989811
166nephron tubule formation (GO:0072079)2.43735553
167cornea development in camera-type eye (GO:0061303)2.42945758
168serotonin metabolic process (GO:0042428)2.42595239
169dopamine transport (GO:0015872)2.41596261
170S-adenosylmethionine metabolic process (GO:0046500)2.40668955
171negative regulation of mast cell activation (GO:0033004)2.39639366
172RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38250545
173embryonic epithelial tube formation (GO:0001838)2.38003071
174positive regulation of sodium ion transmembrane transport (GO:1902307)2.37616261
175epithelial cilium movement (GO:0003351)2.37508743
176cyclic nucleotide catabolic process (GO:0009214)2.35237648
177preassembly of GPI anchor in ER membrane (GO:0016254)2.34692610
178glutamate receptor signaling pathway (GO:0007215)2.31978202
179auditory behavior (GO:0031223)2.31966841
180synaptic transmission, glutamatergic (GO:0035249)2.31709146
181regulation of calcium ion-dependent exocytosis (GO:0017158)2.31084222
182negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.30364876
183cellular response to ATP (GO:0071318)2.29550587
184cilium organization (GO:0044782)2.28319264
185inner ear receptor stereocilium organization (GO:0060122)2.28298836
186regulation of telomere maintenance (GO:0032204)2.27849923
187detection of mechanical stimulus involved in sensory perception (GO:0050974)2.27581948
188axon ensheathment in central nervous system (GO:0032291)10.4311972
189central nervous system myelination (GO:0022010)10.4311972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.69165754
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.60592659
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54216287
4* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse3.06746396
5AR_21572438_ChIP-Seq_LNCaP_Human2.75843870
6GBX2_23144817_ChIP-Seq_PC3_Human2.74569546
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74430520
8IGF1R_20145208_ChIP-Seq_DFB_Human2.41609355
9* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.27829948
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27230329
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.20949194
12EZH2_22144423_ChIP-Seq_EOC_Human2.20890959
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18779221
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15348412
15TAF15_26573619_Chip-Seq_HEK293_Human1.98662072
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87021303
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81944155
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81723855
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80817980
20EWS_26573619_Chip-Seq_HEK293_Human1.79622043
21ER_23166858_ChIP-Seq_MCF-7_Human1.79505234
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79021351
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77072381
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70908276
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70537188
26BCAT_22108803_ChIP-Seq_LS180_Human1.68824142
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66608439
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64896447
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64896447
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64637721
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64540042
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63164153
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.62087134
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.60100352
35DROSHA_22980978_ChIP-Seq_HELA_Human1.59941037
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.59464911
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.58884786
38TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57886185
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.57874117
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.55291847
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54994967
42AR_25329375_ChIP-Seq_VCAP_Human1.54638178
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.52674216
44REST_21632747_ChIP-Seq_MESCs_Mouse1.51281123
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.50235454
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49288264
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48332534
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46796147
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.46660215
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46358721
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.45788561
52STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.45375961
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45338174
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45338174
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42943905
56CBP_20019798_ChIP-Seq_JUKART_Human1.42943905
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42698105
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42563547
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41823994
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.41208387
61* P300_19829295_ChIP-Seq_ESCs_Human1.40030974
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.36277093
63FUS_26573619_Chip-Seq_HEK293_Human1.35340116
64TCF4_22108803_ChIP-Seq_LS180_Human1.31908023
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29576402
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29516583
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29407919
68TP53_16413492_ChIP-PET_HCT116_Human1.29014215
69IRF1_19129219_ChIP-ChIP_H3396_Human1.28490110
70* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27115712
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27013922
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.26785178
73TP53_22573176_ChIP-Seq_HFKS_Human1.23135739
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.22887173
75SOX2_19829295_ChIP-Seq_ESCs_Human1.22454112
76NANOG_19829295_ChIP-Seq_ESCs_Human1.22454112
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22055503
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.21827766
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21581839
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20929185
81* PRDM14_20953172_ChIP-Seq_ESCs_Human1.20353560
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19988433
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.19910258
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19858461
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19674693
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19100681
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.18702931
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18546492
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18503285
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17050766
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16705749
92SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.16692307
93P300_18555785_Chip-Seq_ESCs_Mouse1.16596413
94RNF2_27304074_Chip-Seq_NSC_Mouse1.15800601
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15542761
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14476913
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14404713
98* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13811148
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12502580
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11893010
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11893010
102STAT3_23295773_ChIP-Seq_U87_Human1.11209877
103EOMES_21245162_ChIP-Seq_HESCs_Human1.10280722
104LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09967132
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09635447
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09017143
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.09017143
108VDR_22108803_ChIP-Seq_LS180_Human1.08836856
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08790572
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07923324
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07790105
112SMAD4_21799915_ChIP-Seq_A2780_Human1.07760006
113* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07728857
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.07059927
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06467621
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04899597
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.04309722
118KDM2B_26808549_Chip-Seq_REH_Human1.03947869
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03301297
120P53_22387025_ChIP-Seq_ESCs_Mouse1.03050636
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02428252
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02139470
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.01817737
124RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01781268
125ESR1_20079471_ChIP-ChIP_T-47D_Human1.01778753
126AHR_22903824_ChIP-Seq_MCF-7_Human1.01767043
127* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01740191
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01525985
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.01445200
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01294852
131ESR2_21235772_ChIP-Seq_MCF-7_Human1.00797155
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00780824
133* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00660883
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00188705
135SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98127391
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97553923
137* TCF4_23295773_ChIP-Seq_U87_Human0.97400576
138RUNX2_22187159_ChIP-Seq_PCA_Human0.97227852
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.96632928
140KLF4_18555785_Chip-Seq_ESCs_Mouse0.96136745
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95043259
142* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94915474
143PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94463291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.71196000
2MP0003690_abnormal_glial_cell3.96647560
3MP0004742_abnormal_vestibular_system3.49056982
4MP0003880_abnormal_central_pattern3.34105318
5MP0003011_delayed_dark_adaptation3.20899658
6MP0005171_absent_coat_pigmentation3.20346051
7MP0002102_abnormal_ear_morphology3.01113685
8MP0001529_abnormal_vocalization2.95655073
9MP0004134_abnormal_chest_morphology2.93377053
10MP0003136_yellow_coat_color2.88934852
11MP0003329_amyloid_beta_deposits2.71845895
12MP0006072_abnormal_retinal_apoptosis2.67989928
13MP0001905_abnormal_dopamine_level2.60324670
14MP0004885_abnormal_endolymph2.60265268
15MP0001986_abnormal_taste_sensitivity2.56906406
16MP0008877_abnormal_DNA_methylation2.48673064
17MP0001485_abnormal_pinna_reflex2.42630009
18MP0000462_abnormal_digestive_system2.42561997
19MP0005409_darkened_coat_color2.41957239
20MP0002272_abnormal_nervous_system2.41179878
21MP0001486_abnormal_startle_reflex2.37205149
22MP0000778_abnormal_nervous_system2.32628320
23MP0001501_abnormal_sleep_pattern2.29623945
24MP0003634_abnormal_glial_cell2.29151909
25MP0000569_abnormal_digit_pigmentation2.26442842
26MP0003950_abnormal_plasma_membrane2.20253729
27MP0002064_seizures2.15883492
28MP0003632_abnormal_nervous_system1.97716263
29MP0004270_analgesia1.95519235
30MP0005423_abnormal_somatic_nervous1.91308369
31MP0004142_abnormal_muscle_tone1.90419245
32MP0005410_abnormal_fertilization1.79747237
33MP0005623_abnormal_meninges_morphology1.69530576
34MP0003172_abnormal_lysosome_physiology1.65307023
35MP0001440_abnormal_grooming_behavior1.65298477
36MP0008872_abnormal_physiological_respon1.65102685
37MP0002229_neurodegeneration1.59396703
38MP0002735_abnormal_chemical_nociception1.56384895
39MP0009745_abnormal_behavioral_response1.55770449
40MP0005646_abnormal_pituitary_gland1.54269403
41MP0003806_abnormal_nucleotide_metabolis1.53916796
42MP0004381_abnormal_hair_follicle1.51455586
43MP0003631_nervous_system_phenotype1.49830196
44MP0004145_abnormal_muscle_electrophysio1.48562757
45MP0010678_abnormal_skin_adnexa1.48374011
46MP0000604_amyloidosis1.47412093
47MP0003635_abnormal_synaptic_transmissio1.43610780
48MP0005551_abnormal_eye_electrophysiolog1.42194310
49MP0002572_abnormal_emotion/affect_behav1.41631255
50MP0004147_increased_porphyrin_level1.37587480
51MP0002837_dystrophic_cardiac_calcinosis1.37106799
52MP0008789_abnormal_olfactory_epithelium1.35626925
53MP0000427_abnormal_hair_cycle1.34021476
54MP0001661_extended_life_span1.33548903
55MP0002876_abnormal_thyroid_physiology1.32535572
56MP0004043_abnormal_pH_regulation1.32137922
57MP0003195_calcinosis1.31328072
58MP0003633_abnormal_nervous_system1.30957641
59MP0003787_abnormal_imprinting1.30805699
60MP0002938_white_spotting1.30457941
61MP0001963_abnormal_hearing_physiology1.29213231
62MP0004133_heterotaxia1.29175338
63MP0002882_abnormal_neuron_morphology1.28636880
64MP0002295_abnormal_pulmonary_circulatio1.25793907
65MP0005075_abnormal_melanosome_morpholog1.24462453
66MP0001177_atelectasis1.23343453
67MP0005645_abnormal_hypothalamus_physiol1.22666648
68MP0009046_muscle_twitch1.22456225
69MP0006276_abnormal_autonomic_nervous1.22366809
70MP0002063_abnormal_learning/memory/cond1.21499789
71MP0000383_abnormal_hair_follicle1.19928193
72MP0002734_abnormal_mechanical_nocicepti1.17974311
73MP0000613_abnormal_salivary_gland1.17956465
74MP0005195_abnormal_posterior_eye1.17203351
75MP0002638_abnormal_pupillary_reflex1.16131543
76MP0008569_lethality_at_weaning1.15839734
77MP0002752_abnormal_somatic_nervous1.14745882
78MP0004859_abnormal_synaptic_plasticity1.13646989
79MP0000955_abnormal_spinal_cord1.13311855
80MP0004185_abnormal_adipocyte_glucose1.13075825
81MP0002066_abnormal_motor_capabilities/c1.12950692
82MP0002067_abnormal_sensory_capabilities1.10640835
83MP0001299_abnormal_eye_distance/1.09884283
84MP0000762_abnormal_tongue_morphology1.08429140
85MP0001346_abnormal_lacrimal_gland1.07942338
86MP0001970_abnormal_pain_threshold1.06248833
87MP0002090_abnormal_vision1.02885058
88MP0001502_abnormal_circadian_rhythm1.02228513
89MP0002095_abnormal_skin_pigmentation1.01930409
90MP0005391_vision/eye_phenotype0.96915970
91MP0005408_hypopigmentation0.96868120
92MP0003937_abnormal_limbs/digits/tail_de0.95726947
93MP0004924_abnormal_behavior0.95262792
94MP0005386_behavior/neurological_phenoty0.95262792
95MP0000647_abnormal_sebaceous_gland0.95124851
96MP0006292_abnormal_olfactory_placode0.94647717
97MP0003938_abnormal_ear_development0.93861795
98MP0002653_abnormal_ependyma_morphology0.91994515
99MP0002751_abnormal_autonomic_nervous0.91992544
100MP0003878_abnormal_ear_physiology0.91190441
101MP0005377_hearing/vestibular/ear_phenot0.91190441
102MP0002277_abnormal_respiratory_mucosa0.91188143
103MP0000747_muscle_weakness0.90396032
104MP0001764_abnormal_homeostasis0.86871209
105MP0010030_abnormal_orbit_morphology0.86232526
106MP0002909_abnormal_adrenal_gland0.83598559
107MP0009765_abnormal_xenobiotic_induced0.81582091
108MP0005174_abnormal_tail_pigmentation0.81104473
109MP0008438_abnormal_cutaneous_collagen0.80684644
110MP0004215_abnormal_myocardial_fiber0.80364207
111MP0005503_abnormal_tendon_morphology0.79923603
112MP0002733_abnormal_thermal_nociception0.79527289
113MP0010386_abnormal_urinary_bladder0.79073069
114MP0002133_abnormal_respiratory_system0.78840778
115MP0005388_respiratory_system_phenotype0.78840778
116MP0002138_abnormal_hepatobiliary_system0.78207362
117MP0001968_abnormal_touch/_nociception0.77843349
118MP0005253_abnormal_eye_physiology0.76274442
119MP0008875_abnormal_xenobiotic_pharmacok0.76253883
120MP0009780_abnormal_chondrocyte_physiolo0.76048060
121MP0000467_abnormal_esophagus_morphology0.75986143
122MP0001324_abnormal_eye_pigmentation0.75835673
123MP0003868_abnormal_feces_composition0.75017182
124MP0000026_abnormal_inner_ear0.74466510
125MP0009250_abnormal_appendicular_skeleto0.73801880
126MP0002557_abnormal_social/conspecific_i0.73298657
127MP0005332_abnormal_amino_acid0.72418726
128MP0002152_abnormal_brain_morphology0.72348142
129MP0003119_abnormal_digestive_system0.72259040
130MP0002736_abnormal_nociception_after0.71894746
131MP0000566_synostosis0.68177398
132MP0001851_eye_inflammation0.67877732
133MP0002184_abnormal_innervation0.67606517
134MP0005310_abnormal_salivary_gland0.67361809
135MP0001984_abnormal_olfaction0.66817732
136MP0000631_abnormal_neuroendocrine_gland0.66800558
137MP0005058_abnormal_lysosome_morphology0.66675660
138MP0002822_catalepsy0.66126573
139MP0004036_abnormal_muscle_relaxation0.65617047
140MP0005451_abnormal_body_composition0.65311166
141MP0000749_muscle_degeneration0.64228546
142MP0003385_abnormal_body_wall0.61703088
143MP0004272_abnormal_basement_membrane0.59521913
144MP0000003_abnormal_adipose_tissue0.58611255
145MP0008260_abnormal_autophagy0.58206580
146MP0000372_irregular_coat_pigmentation0.56218190

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.74120132
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.74120132
3Neurofibrillary tangles (HP:0002185)5.79995770
4Abnormality of the corticospinal tract (HP:0002492)5.02575254
5Peripheral hypomyelination (HP:0007182)4.60487171
6Sensory axonal neuropathy (HP:0003390)4.47806304
7Congenital stationary night blindness (HP:0007642)4.27725924
8Parakeratosis (HP:0001036)4.22101524
9Pancreatic cysts (HP:0001737)4.15787922
10Cerebral inclusion bodies (HP:0100314)4.11643484
11Increased serum pyruvate (HP:0003542)4.02542493
12Abnormality of glycolysis (HP:0004366)4.02542493
13Molar tooth sign on MRI (HP:0002419)4.00854089
14Abnormality of midbrain morphology (HP:0002418)4.00854089
15Pancreatic fibrosis (HP:0100732)3.80936415
16Premature skin wrinkling (HP:0100678)3.71550016
17Hyperventilation (HP:0002883)3.67943537
18Nephronophthisis (HP:0000090)3.58509782
19Termporal pattern (HP:0011008)3.47964791
20Insidious onset (HP:0003587)3.47964791
21Increased corneal curvature (HP:0100692)3.44130746
22Keratoconus (HP:0000563)3.44130746
23Onion bulb formation (HP:0003383)3.43680522
24True hermaphroditism (HP:0010459)3.42732958
25Abnormal auditory evoked potentials (HP:0006958)3.39745845
26Cerebral hypomyelination (HP:0006808)3.37389911
27Increased circulating renin level (HP:0000848)3.31931967
28Polydipsia (HP:0001959)3.27382924
29Abnormal drinking behavior (HP:0030082)3.27382924
30Focal motor seizures (HP:0011153)3.24149502
31Retinal dysplasia (HP:0007973)3.22652009
32Attenuation of retinal blood vessels (HP:0007843)3.22109729
33Leukodystrophy (HP:0002415)3.20763849
34Abnormality of the renal medulla (HP:0100957)3.18286878
35Pendular nystagmus (HP:0012043)3.16463306
36Abnormality of the renal cortex (HP:0011035)3.15480617
37Decreased electroretinogram (ERG) amplitude (HP:0000654)3.12364474
38Supranuclear gaze palsy (HP:0000605)3.10823799
39Intention tremor (HP:0002080)3.10614329
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.06706272
41Absent speech (HP:0001344)3.06172482
42Gaze-evoked nystagmus (HP:0000640)3.05254142
43Hypoplastic pelvis (HP:0008839)3.02259254
44Spastic gait (HP:0002064)2.99496567
45Alacrima (HP:0000522)2.95323239
46Abnormality of the parathyroid morphology (HP:0011766)2.91346895
47Hypomagnesemia (HP:0002917)2.88270063
48Inability to walk (HP:0002540)2.87820210
49Polyuria (HP:0000103)2.85901875
50Scanning speech (HP:0002168)2.85723369
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.82956201
52Dysmetria (HP:0001310)2.81961217
53Hemiparesis (HP:0001269)2.80386363
54Medial flaring of the eyebrow (HP:0010747)2.79584758
55Focal seizures (HP:0007359)2.77784439
56Chronic hepatic failure (HP:0100626)2.76822428
57Metabolic alkalosis (HP:0200114)2.76114934
58Cerebral hemorrhage (HP:0001342)2.75062035
59Segmental peripheral demyelination/remyelination (HP:0003481)2.74727268
60Small epiphyses (HP:0010585)2.73570738
61Stridor (HP:0010307)2.71257312
62Cystic liver disease (HP:0006706)2.71090348
63Morphological abnormality of the inner ear (HP:0011390)2.68124143
64Progressive inability to walk (HP:0002505)2.63017805
65Hypokalemic alkalosis (HP:0001949)2.61204653
66Progressive cerebellar ataxia (HP:0002073)2.61064870
67Tubular atrophy (HP:0000092)2.60951147
68Bony spicule pigmentary retinopathy (HP:0007737)2.59528491
69Renal cortical cysts (HP:0000803)2.54213005
70White forelock (HP:0002211)2.53758160
71Hypoplasia of the iris (HP:0007676)2.52988652
72Patchy hypopigmentation of hair (HP:0011365)2.50701276
73Adrenal hypoplasia (HP:0000835)2.49783065
74Esophageal atresia (HP:0002032)2.46202093
75Febrile seizures (HP:0002373)2.44187400
76Pheochromocytoma (HP:0002666)2.44071378
77Clumsiness (HP:0002312)2.41669648
78Decreased lacrimation (HP:0000633)2.41162446
79Anteriorly placed anus (HP:0001545)2.39805382
80Abnormal urine output (HP:0012590)2.39536294
81Decreased central vision (HP:0007663)2.39435887
82Atonic seizures (HP:0010819)2.37608677
83Broad-based gait (HP:0002136)2.36913851
84Gait imbalance (HP:0002141)2.34217474
85Chorioretinal atrophy (HP:0000533)2.33960701
86Spastic paraparesis (HP:0002313)2.33521130
87Renal Fanconi syndrome (HP:0001994)2.32856383
88Slow saccadic eye movements (HP:0000514)2.32652374
89Anomalous pulmonary venous return (HP:0010772)2.28180732
90Epiphyseal dysplasia (HP:0002656)2.26975623
91Congenital ichthyosiform erythroderma (HP:0007431)2.26453368
92Ankle clonus (HP:0011448)2.24405625
93Nephrogenic diabetes insipidus (HP:0009806)2.18468021
94Neuroendocrine neoplasm (HP:0100634)2.17723131
95Acute necrotizing encephalopathy (HP:0006965)2.17692149
96Congenital primary aphakia (HP:0007707)2.16390042
97Abnormality of the labia minora (HP:0012880)2.15246289
98Dialeptic seizures (HP:0011146)2.13364703
99Delayed epiphyseal ossification (HP:0002663)2.11360299
100Cerebellar dysplasia (HP:0007033)2.11230526
101Cupped ear (HP:0000378)2.10969632
102Methylmalonic aciduria (HP:0012120)2.10115374
103Intestinal atresia (HP:0011100)2.09551948
104Hepatosplenomegaly (HP:0001433)2.08908071
105Concave nail (HP:0001598)2.06387522
106Partial agenesis of the corpus callosum (HP:0001338)2.05533011
107Absent septum pellucidum (HP:0001331)2.04758683
108Abnormality of macular pigmentation (HP:0008002)2.04592715
109Abnormal rod and cone electroretinograms (HP:0008323)2.01577295
110Abnormality of renal excretion (HP:0011036)2.01561944
111Aplasia/Hypoplasia involving the musculature (HP:0001460)2.01265035
112Fair hair (HP:0002286)2.00000467
113Abnormality of magnesium homeostasis (HP:0004921)1.99935559
114Axonal loss (HP:0003447)1.99072226
115Widely spaced teeth (HP:0000687)1.98590903
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.98038414
117Optic disc pallor (HP:0000543)1.97376283
118Acute encephalopathy (HP:0006846)1.97271737
119Genital tract atresia (HP:0001827)1.96263732
120Lissencephaly (HP:0001339)1.95315735
121Lower limb muscle weakness (HP:0007340)1.95280929
122Autoamputation (HP:0001218)1.95279473
123Akinesia (HP:0002304)1.94498681
124Abnormality of the pulmonary veins (HP:0011718)1.93429629
125Bowel incontinence (HP:0002607)1.93143049
126Abnormality of alanine metabolism (HP:0010916)1.91972599
127Hyperalaninemia (HP:0003348)1.91972599
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91972599
129Stomach cancer (HP:0012126)1.91596883
130Abnormal biliary tract physiology (HP:0012439)1.89840453
131Bile duct proliferation (HP:0001408)1.89840453
132Abnormality of the vitreous humor (HP:0004327)1.88940377
133CNS hypomyelination (HP:0003429)1.88833007
134Occipital encephalocele (HP:0002085)1.88622000
135Congenital hepatic fibrosis (HP:0002612)1.88328391
136Prolonged QT interval (HP:0001657)1.87601435
137Abnormality of renin-angiotensin system (HP:0000847)1.87578763
138Decreased circulating renin level (HP:0003351)1.86673664
139Coronal craniosynostosis (HP:0004440)1.85630036
140Anencephaly (HP:0002323)1.85590536
141Genetic anticipation (HP:0003743)1.84329733
142Retinitis pigmentosa (HP:0000510)1.83853840
143Postaxial foot polydactyly (HP:0001830)1.81741286
144Hypothermia (HP:0002045)1.81740845
145Hyperaldosteronism (HP:0000859)1.81640508
146Vaginal atresia (HP:0000148)1.81257414
147Aplasia involving bones of the extremities (HP:0009825)1.80638955
148Aplasia involving bones of the upper limbs (HP:0009823)1.80638955
149Aplasia of the phalanges of the hand (HP:0009802)1.80638955
150Morphological abnormality of the pyramidal tract (HP:0002062)1.80364637
151Type II lissencephaly (HP:0007260)1.79885531
152Abnormal large intestine physiology (HP:0012700)1.78272258
153Hypophosphatemic rickets (HP:0004912)1.77707133
154Mitochondrial inheritance (HP:0001427)1.77058183
155Sclerocornea (HP:0000647)1.76997750
156Progressive macrocephaly (HP:0004481)1.76843022
157Action tremor (HP:0002345)1.74477746
158Type II diabetes mellitus (HP:0005978)1.72600639
159Bifid scrotum (HP:0000048)1.71820271
160Large for gestational age (HP:0001520)1.71208075
161Increased hepatocellular lipid droplets (HP:0006565)1.71057103
162Abnormality of the septum pellucidum (HP:0007375)1.70375803
163Peripheral demyelination (HP:0011096)1.69485001
164Septo-optic dysplasia (HP:0100842)1.69323683
165Pachygyria (HP:0001302)1.68942066
166Progressive microcephaly (HP:0000253)1.67537113
167Generalized hypopigmentation of hair (HP:0011358)1.67419334
168Hyperglycinuria (HP:0003108)1.67236977
169Postaxial hand polydactyly (HP:0001162)1.67229606
170Thick nail (HP:0001805)1.67143151
171Abnormality of vitamin B metabolism (HP:0004340)1.66914770
172Split foot (HP:0001839)1.66717903
173Relative macrocephaly (HP:0004482)1.66190191
174Abnormal mitochondria in muscle tissue (HP:0008316)1.66053808
175Macular degeneration (HP:0000608)1.65903743
176Optic nerve hypoplasia (HP:0000609)1.65194148
177Abolished electroretinogram (ERG) (HP:0000550)1.64613847
178Conical tooth (HP:0000698)1.63856501
179Methylmalonic acidemia (HP:0002912)1.63845618
180Paraparesis (HP:0002385)1.63551090
181Furrowed tongue (HP:0000221)1.63548399
182Blue irides (HP:0000635)1.63255969
183Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63250998
184Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63123954
185Dynein arm defect of respiratory motile cilia (HP:0012255)1.63000546
186Steppage gait (HP:0003376)1.62628284
187Chin dimple (HP:0010751)1.61181032
188Abnormality of renal resorption (HP:0011038)1.60419712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.08540085
2EPHB14.84269060
3FRK4.77911642
4TYRO33.89774887
5OXSR13.84670543
6TNIK3.82675276
7MAP4K23.11507460
8FES3.10365919
9INSRR3.08320933
10PKN12.86864344
11MAPKAPK52.85675914
12WNK42.63385863
13PBK2.27256661
14UHMK12.07640385
15IRAK22.07556029
16NUAK12.06444989
17NTRK32.05674473
18ACVR1B2.03279671
19PINK12.00567348
20CASK1.97382062
21MKNK21.77668861
22MST41.77376713
23FGFR21.70629745
24IRAK11.69487592
25PRPF4B1.68190052
26MAPK131.65793699
27BCR1.64264593
28ZAK1.50269750
29ROCK21.46364731
30DAPK21.45886498
31LIMK11.44877204
32MET1.41865648
33ERBB31.39229028
34TAOK31.38970166
35IRAK41.36747735
36NTRK11.35549148
37FGR1.33787380
38MAP3K41.31444481
39WNK11.30438484
40SGK2231.28161787
41SGK4941.28161787
42PNCK1.26910610
43CLK11.24194394
44DYRK21.23007360
45TXK1.14640745
46CSK1.12852168
47ICK1.12650034
48TRIM281.11273965
49EPHA41.05251679
50NEK60.98395510
51TESK20.97041180
52PDGFRB0.96343762
53MARK10.96339651
54CAMK2B0.92138517
55PRKCQ0.91660403
56PRKCG0.90886217
57CAMK2D0.88333832
58GSK3A0.85983775
59CSNK1G30.84895574
60PLK40.80699490
61ADRBK10.79055657
62MAP3K20.78729094
63MARK20.76974490
64CSNK1A1L0.76742156
65GRK50.74009935
66MAPK150.73175367
67MAP3K120.71909083
68PAK30.71819423
69EPHA30.70807603
70TNK20.70578355
71ROCK10.70056867
72INSR0.69052585
73CAMK2A0.68868154
74TGFBR10.66408706
75SGK20.66082645
76WNK30.65523547
77TAF10.65429921
78FER0.63216988
79FYN0.62288723
80PTK2B0.62070885
81CSNK1G10.60310444
82PRKCE0.59830485
83CDK30.58746492
84PRKD10.57197074
85CDK50.57032751
86MKNK10.55225962
87MAPKAPK30.54902254
88DYRK1A0.54374713
89YES10.53865373
90PAK60.53526295
91TRPM70.53315221
92CSNK1G20.52483679
93MAP2K10.52324030
94PLK30.52146408
95VRK10.51695959
96PHKG10.50619782
97PHKG20.50619782
98CDK190.50567505
99MAP2K70.50199505
100PTK20.49611185
101NTRK20.49411882
102GRK70.48781225
103DMPK0.48300775
104PDPK10.48156676
105STK38L0.47675521
106CAMK2G0.45782295
107VRK20.45684903
108RPS6KA50.44128053
109NLK0.43907424
110LATS10.43600404
111TIE10.42933629
112PRKCH0.42841035
113CAMKK20.42541074
114MUSK0.42220112
115BCKDK0.41751478
116AKT30.39025043
117PRKACA0.37322917
118PRKG10.36744660
119PRKCZ0.36413518
120CDK140.36392386
121PRKCI0.35527589
122PRKACB0.35258698
123LCK0.34965521
124IKBKB0.34689443
125SRC0.34410850
126EIF2AK30.33688941
127TLK10.33583474
128TEC0.33560769
129PIK3CA0.32949838
130ADRBK20.32658339
131CSNK1D0.32161187
132ABL20.31933552
133OBSCN0.30266046
134MAP2K20.30248664
135BMPR1B0.29292909
136LYN0.28978244
137GRK10.27292253
138PDK10.27058706
139SGK10.23992402
140CSNK1A10.23575545
141CDK150.23023907
142MELK0.22320690
143PLK20.22160991
144ERBB40.21633781
145MINK10.20837191
146CDK180.18924996
147CDK11A0.17668865
148BMPR20.17405741
149PRKCA0.16956347

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.25628801
2Steroid biosynthesis_Homo sapiens_hsa001005.42435513
3Fatty acid elongation_Homo sapiens_hsa000624.49358585
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.22261711
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79009570
6* Ether lipid metabolism_Homo sapiens_hsa005652.69924718
7Nicotine addiction_Homo sapiens_hsa050332.44289710
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41849145
9Vitamin B6 metabolism_Homo sapiens_hsa007502.12461444
10Sulfur metabolism_Homo sapiens_hsa009202.11554455
11Oxidative phosphorylation_Homo sapiens_hsa001902.05813712
12Selenocompound metabolism_Homo sapiens_hsa004501.93091914
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91335103
14Butanoate metabolism_Homo sapiens_hsa006501.87075612
15Sphingolipid metabolism_Homo sapiens_hsa006001.80992663
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80633159
17Axon guidance_Homo sapiens_hsa043601.66172560
18Tryptophan metabolism_Homo sapiens_hsa003801.63379979
19Insulin secretion_Homo sapiens_hsa049111.57918900
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.55440748
21Taste transduction_Homo sapiens_hsa047421.53892526
22Caffeine metabolism_Homo sapiens_hsa002321.45399596
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44131143
24Glutamatergic synapse_Homo sapiens_hsa047241.43034980
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.41022218
26Collecting duct acid secretion_Homo sapiens_hsa049661.40189474
27Histidine metabolism_Homo sapiens_hsa003401.37424732
28Linoleic acid metabolism_Homo sapiens_hsa005911.37312867
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36485477
30Homologous recombination_Homo sapiens_hsa034401.35014511
31Alzheimers disease_Homo sapiens_hsa050101.33942601
32Parkinsons disease_Homo sapiens_hsa050121.32496282
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29183194
34Protein export_Homo sapiens_hsa030601.28891593
35Olfactory transduction_Homo sapiens_hsa047401.27578712
36ABC transporters_Homo sapiens_hsa020101.26702136
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26010540
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23641725
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21942366
40Serotonergic synapse_Homo sapiens_hsa047261.17598457
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16355822
42Fanconi anemia pathway_Homo sapiens_hsa034601.13139999
43Fatty acid metabolism_Homo sapiens_hsa012121.11249096
44RNA polymerase_Homo sapiens_hsa030201.09485996
45Long-term depression_Homo sapiens_hsa047301.06042635
46Amphetamine addiction_Homo sapiens_hsa050311.02086349
47Renal cell carcinoma_Homo sapiens_hsa052111.01760167
48Arginine and proline metabolism_Homo sapiens_hsa003300.98951628
49Cholinergic synapse_Homo sapiens_hsa047250.98848709
50Sphingolipid signaling pathway_Homo sapiens_hsa040710.97230137
51Regulation of autophagy_Homo sapiens_hsa041400.94374038
52Propanoate metabolism_Homo sapiens_hsa006400.93563068
53Basal transcription factors_Homo sapiens_hsa030220.93238723
54Calcium signaling pathway_Homo sapiens_hsa040200.91994964
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89587397
56Vibrio cholerae infection_Homo sapiens_hsa051100.88269320
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.86041045
58Choline metabolism in cancer_Homo sapiens_hsa052310.84962930
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84872192
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84428402
61Peroxisome_Homo sapiens_hsa041460.83118978
62RNA degradation_Homo sapiens_hsa030180.82693297
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80643542
64Chemical carcinogenesis_Homo sapiens_hsa052040.79995660
65Prion diseases_Homo sapiens_hsa050200.79409994
66GABAergic synapse_Homo sapiens_hsa047270.78211247
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.77513687
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73331460
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71875784
70Primary immunodeficiency_Homo sapiens_hsa053400.71300478
71Non-homologous end-joining_Homo sapiens_hsa034500.69762009
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67257995
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66168579
74Tight junction_Homo sapiens_hsa045300.64659572
75cAMP signaling pathway_Homo sapiens_hsa040240.62687052
76Other glycan degradation_Homo sapiens_hsa005110.62328640
77Huntingtons disease_Homo sapiens_hsa050160.62220566
78Circadian rhythm_Homo sapiens_hsa047100.62129838
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.61821178
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.61302858
81Rheumatoid arthritis_Homo sapiens_hsa053230.60685338
82Ovarian steroidogenesis_Homo sapiens_hsa049130.60616985
83Arachidonic acid metabolism_Homo sapiens_hsa005900.60062279
84Glutathione metabolism_Homo sapiens_hsa004800.55161190
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53105141
86Pyruvate metabolism_Homo sapiens_hsa006200.52049082
87Ras signaling pathway_Homo sapiens_hsa040140.51833897
88Phagosome_Homo sapiens_hsa041450.50812274
89Dopaminergic synapse_Homo sapiens_hsa047280.50323661
90Vitamin digestion and absorption_Homo sapiens_hsa049770.50028506
91Fatty acid biosynthesis_Homo sapiens_hsa000610.48858926
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.48649715
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48153194
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47915419
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47804158
96Mineral absorption_Homo sapiens_hsa049780.47797536
97ECM-receptor interaction_Homo sapiens_hsa045120.47760109
98Purine metabolism_Homo sapiens_hsa002300.47675503
99Gastric acid secretion_Homo sapiens_hsa049710.47635165
100One carbon pool by folate_Homo sapiens_hsa006700.47604901
101Fat digestion and absorption_Homo sapiens_hsa049750.45035645
102Morphine addiction_Homo sapiens_hsa050320.44618038
103Salivary secretion_Homo sapiens_hsa049700.43842542
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42683746
105beta-Alanine metabolism_Homo sapiens_hsa004100.42371606
106Oxytocin signaling pathway_Homo sapiens_hsa049210.41237664
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41043868
108Thyroid hormone synthesis_Homo sapiens_hsa049180.40985009
109Metabolic pathways_Homo sapiens_hsa011000.40696331
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40651487
111Cardiac muscle contraction_Homo sapiens_hsa042600.40313376
112Pancreatic secretion_Homo sapiens_hsa049720.39817482
113Lysosome_Homo sapiens_hsa041420.37911084
114Gap junction_Homo sapiens_hsa045400.34784818
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33961158
116Endocytosis_Homo sapiens_hsa041440.33546021
117Platelet activation_Homo sapiens_hsa046110.33541343
118Tyrosine metabolism_Homo sapiens_hsa003500.32879591
119Glycerolipid metabolism_Homo sapiens_hsa005610.32770665
120Renin secretion_Homo sapiens_hsa049240.31807418
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31803134
122Circadian entrainment_Homo sapiens_hsa047130.31317579
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30972943
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28309993
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27829107
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26931596
127Synaptic vesicle cycle_Homo sapiens_hsa047210.26757078
128Fatty acid degradation_Homo sapiens_hsa000710.23387875
129Phototransduction_Homo sapiens_hsa047440.23377445
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23318958
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21893602
132Retinol metabolism_Homo sapiens_hsa008300.21730887
133Hedgehog signaling pathway_Homo sapiens_hsa043400.19620778
134Viral myocarditis_Homo sapiens_hsa054160.19577994
135Dorso-ventral axis formation_Homo sapiens_hsa043200.19223683
136Nitrogen metabolism_Homo sapiens_hsa009100.18763056
137Cocaine addiction_Homo sapiens_hsa050300.18742747
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17799559

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