ENPP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)9.09769801
2vitamin A metabolic process (GO:0006776)8.49194576
3adhesion of symbiont to host cell (GO:0044650)7.46715147
4virion attachment to host cell (GO:0019062)7.46715147
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.62113079
6phospholipid efflux (GO:0033700)6.46568291
7flavonoid metabolic process (GO:0009812)6.42217760
8regulation of cholesterol esterification (GO:0010872)6.15575696
9hormone catabolic process (GO:0042447)6.15250647
10adhesion of symbiont to host (GO:0044406)6.13560189
11plasma lipoprotein particle assembly (GO:0034377)6.00623924
12positive regulation of lipoprotein lipase activity (GO:0051006)5.97639573
13positive regulation of triglyceride lipase activity (GO:0061365)5.97639573
14actin filament depolymerization (GO:0030042)5.91923676
15L-phenylalanine catabolic process (GO:0006559)5.91709630
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.91709630
17urea metabolic process (GO:0019627)5.89365295
18cellular glucuronidation (GO:0052695)5.86106103
19regulation of triglyceride catabolic process (GO:0010896)5.84931079
20drug catabolic process (GO:0042737)5.76010922
21protein-lipid complex assembly (GO:0065005)5.73243973
22peptide hormone processing (GO:0016486)5.66661569
23peptidyl-glutamic acid carboxylation (GO:0017187)5.63211341
24protein carboxylation (GO:0018214)5.63211341
25uronic acid metabolic process (GO:0006063)5.61840251
26glucuronate metabolic process (GO:0019585)5.61840251
27fat-soluble vitamin biosynthetic process (GO:0042362)5.53590055
28L-phenylalanine metabolic process (GO:0006558)5.46285762
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.46285762
30lipoprotein metabolic process (GO:0042157)5.36926198
31cholesterol efflux (GO:0033344)5.36394482
32urea cycle (GO:0000050)5.35218168
33nitrogen cycle metabolic process (GO:0071941)5.32453476
34digestive system process (GO:0022600)5.31446067
35very-low-density lipoprotein particle assembly (GO:0034379)5.29101323
36bile acid and bile salt transport (GO:0015721)5.23318554
37modified amino acid transport (GO:0072337)5.16666091
38regulation of fibrinolysis (GO:0051917)5.15575186
39peptide catabolic process (GO:0043171)5.15336498
40negative regulation of fibrinolysis (GO:0051918)5.13919721
41digestion (GO:0007586)5.08384446
42drinking behavior (GO:0042756)5.06252652
43complement activation, alternative pathway (GO:0006957)4.97483788
44ethanol oxidation (GO:0006069)4.92070842
45lipoprotein transport (GO:0042953)4.89937338
46epoxygenase P450 pathway (GO:0019373)4.83731939
47bile acid metabolic process (GO:0008206)4.77134790
48regulation of protein activation cascade (GO:2000257)4.73137686
49alkaloid metabolic process (GO:0009820)4.70371054
50glucose 6-phosphate metabolic process (GO:0051156)4.68668881
51cellular response to hepatocyte growth factor stimulus (GO:0035729)4.61569451
52response to hepatocyte growth factor (GO:0035728)4.61569451
53purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.60623545
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.60623545
55glyoxylate metabolic process (GO:0046487)4.59387991
56reverse cholesterol transport (GO:0043691)4.57969240
57regulation of complement activation (GO:0030449)4.49298813
58cholesterol transport (GO:0030301)4.40911172
59sterol transport (GO:0015918)4.40911172
60oligosaccharide catabolic process (GO:0009313)4.39134726
61positive regulation of fatty acid biosynthetic process (GO:0045723)4.34736392
62cholesterol homeostasis (GO:0042632)4.29860602
63diacylglycerol metabolic process (GO:0046339)4.28009358
64sterol homeostasis (GO:0055092)4.24738172
65aromatic amino acid family catabolic process (GO:0009074)4.15656608
66regulation of bile acid biosynthetic process (GO:0070857)4.15555726
67acylglycerol homeostasis (GO:0055090)4.11569943
68triglyceride homeostasis (GO:0070328)4.11569943
69negative regulation of sterol transport (GO:0032372)4.11245984
70negative regulation of cholesterol transport (GO:0032375)4.11245984
71fibrinolysis (GO:0042730)4.11179216
72bile acid biosynthetic process (GO:0006699)4.06791547
73regulation of systemic arterial blood pressure by hormone (GO:0001990)4.03572227
74regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.03572227
75endocrine process (GO:0050886)4.03572227
76high-density lipoprotein particle remodeling (GO:0034375)4.01901635
77arginine metabolic process (GO:0006525)3.98212861
78oxidative demethylation (GO:0070989)3.91651865
79plasma lipoprotein particle remodeling (GO:0034369)3.89308542
80protein-lipid complex remodeling (GO:0034368)3.89308542
81macromolecular complex remodeling (GO:0034367)3.89308542
82ethanol metabolic process (GO:0006067)3.87400355
83nucleobase catabolic process (GO:0046113)3.85686916
84heme transport (GO:0015886)3.84812177
85phenylpropanoid metabolic process (GO:0009698)3.82748357
86fructose metabolic process (GO:0006000)3.82420999
87plasma lipoprotein particle organization (GO:0071827)3.76411991
88L-alpha-amino acid transmembrane transport (GO:1902475)3.75423584
89protein-lipid complex subunit organization (GO:0071825)3.74979241
90phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.73201835
91bundle of His cell to Purkinje myocyte communication (GO:0086069)3.72702743
92blood coagulation, intrinsic pathway (GO:0007597)3.71486662
93amino-acid betaine metabolic process (GO:0006577)3.65459198
94negative regulation of lipase activity (GO:0060192)3.64518104
95positive regulation of triglyceride metabolic process (GO:0090208)3.60535407
96fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.60176993
97serine family amino acid catabolic process (GO:0009071)3.59485486
98negative regulation of hemostasis (GO:1900047)3.58406693
99negative regulation of blood coagulation (GO:0030195)3.58406693
100regulation of lipoprotein metabolic process (GO:0050746)3.54629695
101purine nucleotide salvage (GO:0032261)3.53695916
102complement activation, classical pathway (GO:0006958)3.53237675
103tyrosine metabolic process (GO:0006570)3.53034598
104cellular carbohydrate catabolic process (GO:0044275)3.52337882
105regulation of systemic arterial blood pressure (GO:0003073)3.49383581
106regulation of plasminogen activation (GO:0010755)3.46965408
107protein activation cascade (GO:0072376)3.46621208
108proline metabolic process (GO:0006560)3.43461584
109response to hydroperoxide (GO:0033194)3.42025552
110S-adenosylmethionine metabolic process (GO:0046500)3.41580961
111vitamin biosynthetic process (GO:0009110)3.40914872
112glutamine family amino acid biosynthetic process (GO:0009084)3.40398081
113acute-phase response (GO:0006953)3.37947224
114drug transmembrane transport (GO:0006855)3.36747246
115regulation of guanylate cyclase activity (GO:0031282)3.34114350
116sulfate transmembrane transport (GO:1902358)3.32900024
117complement activation (GO:0006956)3.31269587
118positive regulation of lipid catabolic process (GO:0050996)3.30981037
119omega-hydroxylase P450 pathway (GO:0097267)3.28857286
120negative regulation of coagulation (GO:0050819)3.28260193
121regulation of cholesterol homeostasis (GO:2000188)3.26065859
122sulfur compound transport (GO:0072348)3.25698614
123NADH metabolic process (GO:0006734)3.22982310
124xenobiotic metabolic process (GO:0006805)3.21760242
125low-density lipoprotein particle remodeling (GO:0034374)3.21588467
126regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.21234360
127negative regulation of wound healing (GO:0061045)3.19610060
128thyroid hormone metabolic process (GO:0042403)3.19268185
129regulation of digestive system process (GO:0044058)3.18068510
130drug metabolic process (GO:0017144)3.11879603
131regulation of cholesterol transport (GO:0032374)3.11229994
132regulation of sterol transport (GO:0032371)3.11229994
133neutral amino acid transport (GO:0015804)3.08194174
134sulfation (GO:0051923)3.07842106
135negative regulation of digestive system process (GO:0060457)3.06180693
136response to phenylpropanoid (GO:0080184)3.05483380
137transepithelial transport (GO:0070633)2.98926796
138negative regulation of sodium ion transport (GO:0010766)2.95530700
139UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95284949
140polyol transport (GO:0015791)2.94970856
141lipid homeostasis (GO:0055088)2.92431824
142positive regulation of T cell differentiation in thymus (GO:0033089)2.90720349
143regulation of actin nucleation (GO:0051125)2.89746043
144positive regulation of p38MAPK cascade (GO:1900745)2.88368291
145glycerol metabolic process (GO:0006071)2.87308265
146cellular anion homeostasis (GO:0030002)2.85668697
147drug transport (GO:0015893)2.85114079
148fat-soluble vitamin metabolic process (GO:0006775)2.85032507
149thrombin receptor signaling pathway (GO:0070493)2.76436031
150activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.76041675
151COPII vesicle coating (GO:0048208)2.75792390
152exogenous drug catabolic process (GO:0042738)2.73777098
153plasma lipoprotein particle clearance (GO:0034381)2.73644918
154angiotensin maturation (GO:0002003)14.5766351
155intestinal cholesterol absorption (GO:0030299)12.8616240
156intestinal absorption (GO:0050892)12.8135400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.69209940
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.33029467
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.36581180
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.29623567
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.24658914
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.99241954
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.86212792
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.78155985
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.66876449
10* LXR_22158963_ChIP-Seq_LIVER_Mouse2.65544552
11* GATA4_25053715_ChIP-Seq_YYC3_Human2.64639006
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.54569123
13GATA6_25053715_ChIP-Seq_YYC3_Human2.39758579
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32780924
15SOX2_20726797_ChIP-Seq_SW620_Human2.27882893
16PPAR_26484153_Chip-Seq_NCI-H1993_Human2.07734310
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04860847
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98047053
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.85220309
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78840946
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78345121
22KLF5_25053715_ChIP-Seq_YYC3_Human1.69070274
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68987789
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.68760221
25* BCL6_27268052_Chip-Seq_Bcells_Human1.67679507
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67122707
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65648446
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63775360
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62182731
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.59244572
31P68_20966046_ChIP-Seq_HELA_Human1.56937641
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.55371495
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55176344
34GATA2_19941826_ChIP-Seq_K562_Human1.54902479
35VDR_21846776_ChIP-Seq_THP-1_Human1.54797518
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53813850
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52984293
38* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.52486278
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.52262954
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.49255994
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45148194
42* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45092601
43GATA1_22025678_ChIP-Seq_K562_Human1.44013840
44E2F1_20622854_ChIP-Seq_HELA_Human1.42852225
45SA1_27219007_Chip-Seq_Bcells_Human1.41195577
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41048012
47CLOCK_20551151_ChIP-Seq_293T_Human1.40479224
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39673021
49* TET1_21451524_ChIP-Seq_MESCs_Mouse1.39659198
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39582543
51PHF8_20622854_ChIP-Seq_HELA_Human1.38900464
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38303167
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38166978
54* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37942460
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35777267
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.35565731
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31185341
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.30527229
59RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30033872
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.29948746
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.29798825
62BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29727565
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27438571
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.27396210
65RACK7_27058665_Chip-Seq_MCF-7_Human1.27042899
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26418634
67SMC4_20622854_ChIP-Seq_HELA_Human1.25861498
68JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.25826717
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25147694
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24776947
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23322252
72RARA_24833708_ChIP-Seq_LIVER_Mouse1.22901738
73ATF3_27146783_Chip-Seq_COLON_Human1.19889533
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19639834
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19358471
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19191372
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17126470
78EGR1_19032775_ChIP-ChIP_M12_Human1.16803345
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16277492
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16118737
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14380694
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13857411
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13817798
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13251067
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13092870
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11989799
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11790010
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11650844
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11307901
90* CTCF_20526341_ChIP-Seq_ESCs_Human1.10024608
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07874984
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.07511183
93* SOX2_21211035_ChIP-Seq_LN229_Human1.07445711
94* TAF2_19829295_ChIP-Seq_ESCs_Human1.07429477
95P300_27268052_Chip-Seq_Bcells_Human1.06673407
96GATA1_19941826_ChIP-Seq_K562_Human1.05497623
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.04601839
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04090801
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03016454
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01435950
101DROSHA_22980978_ChIP-Seq_HELA_Human1.01223403
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.01066533
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.00988503
104* P53_21459846_ChIP-Seq_SAOS-2_Human0.98946441
105* CREB1_26743006_Chip-Seq_LNCaP_Human0.97625495
106CEBPB_22108803_ChIP-Seq_LS180_Human0.96272310
107VDR_24763502_ChIP-Seq_THP-1_Human0.96208443
108LXR_22292898_ChIP-Seq_THP-1_Human0.95769663
109ETS1_21867929_ChIP-Seq_TH2_Mouse0.95314406
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95159271
111* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95143057
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93875850
113P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93847507
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93500916
115RARB_24833708_ChIP-Seq_LIVER_Mouse0.93195987
116RAC3_21632823_ChIP-Seq_H3396_Human0.92937529
117TP63_23658742_ChIP-Seq_EP156T_Human0.92225225
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91522617
119IRF8_21731497_ChIP-ChIP_J774_Mouse0.91125083
120VDR_22108803_ChIP-Seq_LS180_Human0.90621652
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90299330
122SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90231993
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87960267
124TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87451735
125YY1_22570637_ChIP-Seq_MALME-3M_Human0.87367464
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86246436
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86206283
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85832943
129* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85512072
130MYC_19829295_ChIP-Seq_ESCs_Human0.85150833
131CTCF_21964334_Chip-Seq_Bcells_Human0.85121069
132CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85058372
133ERA_21632823_ChIP-Seq_H3396_Human0.84726835
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83981864
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83162997
136OCT4_20526341_ChIP-Seq_ESCs_Human0.83000103
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81291715
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.80976392
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80289658
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80241052
141P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.80182419
142BCOR_27268052_Chip-Seq_Bcells_Human0.79984365
143* CTCF_27219007_Chip-Seq_Bcells_Human0.79857655
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.77402734
145NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77221325
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76060160
147TP53_16413492_ChIP-PET_HCT116_Human0.75429929
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73880432
149GATA1_19941827_ChIP-Seq_MEL_Mouse0.72970809
150NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72874596
151NANOG_20526341_ChIP-Seq_ESCs_Human0.72528673
152ZNF263_19887448_ChIP-Seq_K562_Human0.71647972
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71629189
154STAT6_21828071_ChIP-Seq_BEAS2B_Human0.67997591
155SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.67959235
156SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.67959235
157KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.67939295
158TP63_22573176_ChIP-Seq_HFKS_Human0.67460633
159WT1_25993318_ChIP-Seq_PODOCYTE_Human0.66505595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption6.50373451
2MP0009840_abnormal_foam_cell5.03514595
3MP0003183_abnormal_peptide_metabolism4.84203782
4MP0002139_abnormal_hepatobiliary_system3.69046037
5MP0008875_abnormal_xenobiotic_pharmacok3.64150432
6MP0010234_abnormal_vibrissa_follicle3.18165026
7MP0003252_abnormal_bile_duct3.15116642
8MP0004264_abnormal_extraembryonic_tissu3.12618116
9MP0010329_abnormal_lipoprotein_level3.07445431
10MP0005085_abnormal_gallbladder_physiolo2.94765283
11MP0003195_calcinosis2.84408854
12MP0000462_abnormal_digestive_system2.69945455
13MP0002822_catalepsy2.46200123
14MP0003868_abnormal_feces_composition2.41133390
15MP0003866_abnormal_defecation2.34421534
16MP0005084_abnormal_gallbladder_morpholo2.33528589
17MP0002138_abnormal_hepatobiliary_system2.27689808
18MP0004019_abnormal_vitamin_homeostasis2.25205427
19MP0004147_increased_porphyrin_level2.01387429
20MP0005360_urolithiasis10.1263705
21MP0003878_abnormal_ear_physiology1.98517559
22MP0005377_hearing/vestibular/ear_phenot1.98517559
23MP0005409_darkened_coat_color1.89168922
24MP0005448_abnormal_energy_balance1.70469172
25MP0002254_reproductive_system_inflammat1.67209713
26MP0001664_abnormal_digestion1.63573209
27MP0005365_abnormal_bile_salt1.61179724
28MP0003705_abnormal_hypodermis_morpholog1.60891417
29MP0000538_abnormal_urinary_bladder1.54954702
30MP0000537_abnormal_urethra_morphology1.51442520
31MP0004043_abnormal_pH_regulation1.51007501
32MP0003191_abnormal_cellular_cholesterol1.48380381
33MP0010352_gastrointestinal_tract_polyps1.46004523
34MP0009697_abnormal_copulation1.45029970
35MP0002089_abnormal_postnatal_growth/wei1.44708738
36MP0001986_abnormal_taste_sensitivity1.39514072
37MP0005381_digestive/alimentary_phenotyp1.35680126
38MP0002796_impaired_skin_barrier1.30855443
39MP0005670_abnormal_white_adipose1.27991132
40MP0001663_abnormal_digestive_system1.26681969
41MP0003300_gastrointestinal_ulcer1.25248685
42MP0004270_analgesia1.23541248
43MP0006054_spinal_hemorrhage1.23540001
44MP0000477_abnormal_intestine_morphology1.21473181
45MP0010155_abnormal_intestine_physiology1.20916834
46MP0005332_abnormal_amino_acid1.20826412
47MP0002118_abnormal_lipid_homeostasis1.13467650
48MP0009379_abnormal_foot_pigmentation1.06341328
49MP0001756_abnormal_urination1.03912906
50MP0001873_stomach_inflammation1.03095146
51MP0000609_abnormal_liver_physiology1.02278807
52MP0009643_abnormal_urine_homeostasis1.00743892
53MP0003718_maternal_effect0.97410531
54MP0005174_abnormal_tail_pigmentation0.94904084
55MP0001188_hyperpigmentation0.90486964
56MP0004947_skin_inflammation0.89892531
57MP0000490_abnormal_crypts_of0.89191150
58MP0005058_abnormal_lysosome_morphology0.87567840
59MP0001849_ear_inflammation0.87550065
60MP0005167_abnormal_blood-brain_barrier0.87040825
61MP0003806_abnormal_nucleotide_metabolis0.86894250
62MP0009780_abnormal_chondrocyte_physiolo0.86639886
63MP0008872_abnormal_physiological_respon0.86005518
64MP0009053_abnormal_anal_canal0.85493248
65MP0008469_abnormal_protein_level0.84604348
66MP0005266_abnormal_metabolism0.81110125
67MP0005535_abnormal_body_temperature0.76515432
68MP0009765_abnormal_xenobiotic_induced0.75800773
69MP0000467_abnormal_esophagus_morphology0.75173329
70MP0003950_abnormal_plasma_membrane0.75080185
71MP0005501_abnormal_skin_physiology0.75026976
72MP0001661_extended_life_span0.74057391
73MP0001764_abnormal_homeostasis0.72367414
74MP0005367_renal/urinary_system_phenotyp0.72339175
75MP0000516_abnormal_urinary_system0.72339175
76MP0003638_abnormal_response/metabolism_0.72337970
77MP0004782_abnormal_surfactant_physiolog0.71448029
78MP0005166_decreased_susceptibility_to0.70573482
79MP0010678_abnormal_skin_adnexa0.69486491
80MP0000604_amyloidosis0.69036434
81MP0005319_abnormal_enzyme/_coenzyme0.68795853
82MP0003879_abnormal_hair_cell0.67999264
83MP0002098_abnormal_vibrissa_morphology0.66309406
84MP0003283_abnormal_digestive_organ0.66170239
85MP0006138_congestive_heart_failure0.65518111
86MP0002876_abnormal_thyroid_physiology0.64418962
87MP0009384_cardiac_valve_regurgitation0.59928418
88MP0009785_altered_susceptibility_to0.59925695
89MP0005376_homeostasis/metabolism_phenot0.59557583
90MP0003136_yellow_coat_color0.58409839
91MP0001845_abnormal_inflammatory_respons0.57548560
92MP0005584_abnormal_enzyme/coenzyme_acti0.56748900
93MP0009764_decreased_sensitivity_to0.56659865
94MP0005395_other_phenotype0.56255299
95MP0002136_abnormal_kidney_physiology0.55849008
96MP0001765_abnormal_ion_homeostasis0.54598866
97MP0005171_absent_coat_pigmentation0.54502546
98MP0009642_abnormal_blood_homeostasis0.54041287
99MP0009115_abnormal_fat_cell0.52985630
100MP0000678_abnormal_parathyroid_gland0.52067366
101MP0000566_synostosis0.51924153
102MP0000013_abnormal_adipose_tissue0.49856712
103MP0003453_abnormal_keratinocyte_physiol0.48262311
104MP0009763_increased_sensitivity_to0.48170623
105MP0005451_abnormal_body_composition0.47777015
106MP0004858_abnormal_nervous_system0.47442890
107MP0003329_amyloid_beta_deposits0.47182087
108MP0000427_abnormal_hair_cycle0.46991341
109MP0000230_abnormal_systemic_arterial0.46605356
110MP0001881_abnormal_mammary_gland0.46339966
111MP0005636_abnormal_mineral_homeostasis0.45466660
112MP0001191_abnormal_skin_condition0.44714482
113MP0003953_abnormal_hormone_level0.43803000
114MP0005334_abnormal_fat_pad0.43787851
115MP0001216_abnormal_epidermal_layer0.43709811
116MP0005408_hypopigmentation0.43603936
117MP0002078_abnormal_glucose_homeostasis0.42138599
118MP0005023_abnormal_wound_healing0.41437657
119MP0003436_decreased_susceptibility_to0.40934008
120MP0002971_abnormal_brown_adipose0.40023260
121MP0002249_abnormal_larynx_morphology0.39615682
122MP0008260_abnormal_autophagy0.39354060
123MP0000249_abnormal_blood_vessel0.39118622
124MP0003385_abnormal_body_wall0.38619739
125MP0001485_abnormal_pinna_reflex0.38595626
126MP0002638_abnormal_pupillary_reflex0.38425278
127MP0008873_increased_physiological_sensi0.36884657
128MP0005083_abnormal_biliary_tract0.35892519
129MP0000579_abnormal_nail_morphology0.35295349
130MP0009333_abnormal_splenocyte_physiolog0.34977067
131MP0002933_joint_inflammation0.34468209
132MP0004885_abnormal_endolymph0.34201688
133MP0005025_abnormal_response_to0.33493045
134MP0000598_abnormal_liver_morphology0.33129836
135MP0005464_abnormal_platelet_physiology0.31871372
136MP0005330_cardiomyopathy0.30180140
137MP0008874_decreased_physiological_sensi0.29696986
138MP0000003_abnormal_adipose_tissue0.29554128

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)8.52573906
2Acanthocytosis (HP:0001927)8.42472718
3Ileus (HP:0002595)7.87910789
4Abnormality of glutamine family amino acid metabolism (HP:0010902)7.73388614
5Abnormality of proline metabolism (HP:0010907)6.51613747
6Hydroxyprolinuria (HP:0003080)6.51613747
7Prolonged partial thromboplastin time (HP:0003645)6.38679828
8Deep venous thrombosis (HP:0002625)6.19534276
9Autoimmune thrombocytopenia (HP:0001973)5.95038529
10Malnutrition (HP:0004395)5.94194101
11Abnormality of aromatic amino acid family metabolism (HP:0004338)5.60571353
12Complement deficiency (HP:0004431)5.49619631
13Conjugated hyperbilirubinemia (HP:0002908)5.41910097
14Joint hemorrhage (HP:0005261)5.12076860
15Widely patent fontanelles and sutures (HP:0004492)5.11800145
16Hyperlipoproteinemia (HP:0010980)5.07874044
17Hypolipoproteinemia (HP:0010981)5.03019598
18Pigmentary retinal degeneration (HP:0001146)4.94744439
19Systemic lupus erythematosus (HP:0002725)4.93972555
20Potter facies (HP:0002009)4.85079229
21Facial shape deformation (HP:0011334)4.85079229
22Poikilocytosis (HP:0004447)4.66256456
23Abnormality of complement system (HP:0005339)4.53157379
24Right ventricular cardiomyopathy (HP:0011663)4.51905009
25Cupped ribs (HP:0000887)4.46787759
26Autoimmune hemolytic anemia (HP:0001890)4.39559517
27Fat malabsorption (HP:0002630)4.38733069
28Hemorrhage of the eye (HP:0011885)4.10021860
29Hyperglycinuria (HP:0003108)3.96722398
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.92969364
31Glomerulonephritis (HP:0000099)3.90437548
32Abnormality of the common coagulation pathway (HP:0010990)3.90420121
33Chronic diarrhea (HP:0002028)3.81529549
34Xanthomatosis (HP:0000991)3.78860662
35Abnormality of pyrimidine metabolism (HP:0004353)3.70362629
36Increased IgE level (HP:0003212)3.51008259
37Mesangial abnormality (HP:0001966)3.45137784
38Abnormality of the intrinsic pathway (HP:0010989)3.40945145
39Abdominal distention (HP:0003270)3.38515092
40Wide cranial sutures (HP:0010537)3.28329337
41Glycosuria (HP:0003076)3.17315530
42Abnormality of urine glucose concentration (HP:0011016)3.17315530
43Abnormal glucose tolerance (HP:0001952)3.10361481
44Dehydration (HP:0001944)3.08300617
45Epidermoid cyst (HP:0200040)3.06560677
46Hyperammonemia (HP:0001987)3.05088090
47Steatorrhea (HP:0002570)3.04359108
48Hypercholesterolemia (HP:0003124)2.99280996
49Nephrolithiasis (HP:0000787)2.96346732
50Gastrointestinal dysmotility (HP:0002579)2.93212828
51B lymphocytopenia (HP:0010976)2.91871431
52Abnormality of B cell number (HP:0010975)2.91871431
53Abnormality of the vitamin B12 metabolism (HP:0004341)2.86021529
54Rickets (HP:0002748)2.84642885
55Nephritis (HP:0000123)2.80846446
56Reticulocytosis (HP:0001923)2.79536141
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.77167090
58Severe combined immunodeficiency (HP:0004430)2.75860661
59Increased mean platelet volume (HP:0011877)2.74741128
60Abnormality of serine family amino acid metabolism (HP:0010894)2.72716189
61Abnormality of glycine metabolism (HP:0010895)2.72716189
62Hypophosphatemic rickets (HP:0004912)2.72707680
63Abnormality of vitamin B metabolism (HP:0004340)2.66455187
64Abnormality of purine metabolism (HP:0004352)2.63692110
65Spontaneous abortion (HP:0005268)2.62823500
66Generalized aminoaciduria (HP:0002909)2.61865620
67Vaginal fistula (HP:0004320)2.57791837
68Polycythemia (HP:0001901)2.54944939
69Thyroiditis (HP:0100646)2.47051517
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46836719
71Confusion (HP:0001289)2.46783165
72Combined immunodeficiency (HP:0005387)2.46721111
73Vascular calcification (HP:0004934)2.45716635
74Abnormal platelet volume (HP:0011876)2.41651951
75Mildly elevated creatine phosphokinase (HP:0008180)2.41221799
76Hyperglycinemia (HP:0002154)2.39406895
77Intrahepatic cholestasis (HP:0001406)2.37436233
78Metabolic acidosis (HP:0001942)2.36923182
79Progressive sensorineural hearing impairment (HP:0000408)2.31401823
80Hyperphosphaturia (HP:0003109)2.29189515
81Abnormality of vitamin metabolism (HP:0100508)2.28568582
82Alkalosis (HP:0001948)2.25049182
83Abnormality of sulfur amino acid metabolism (HP:0004339)2.21320179
84Megaloblastic anemia (HP:0001889)2.18784318
85Abnormality of the gastric mucosa (HP:0004295)2.18370142
86Delayed epiphyseal ossification (HP:0002663)2.17363927
87Abnormality of nucleobase metabolism (HP:0010932)2.16241673
88Proximal tubulopathy (HP:0000114)2.14956568
89Cardiovascular calcification (HP:0011915)2.11203289
90Myopathic facies (HP:0002058)2.10154686
91Irritability (HP:0000737)2.09323184
92Abnormality of serum amino acid levels (HP:0003112)2.05403011
93Recurrent gram-negative bacterial infections (HP:0005420)2.04433878
94Progressive hearing impairment (HP:0001730)2.02190986
95Villous atrophy (HP:0011473)1.99769426
96Abnormality of small intestinal villus morphology (HP:0011472)1.99769426
97Alopecia of scalp (HP:0002293)1.99687850
98Amyloidosis (HP:0011034)1.97537029
99Abnormal enzyme/coenzyme activity (HP:0012379)1.96522565
100Neonatal onset (HP:0003623)1.96250955
101Flat acetabular roof (HP:0003180)1.95949159
102Delayed CNS myelination (HP:0002188)1.95803470
103Abnormality of alkaline phosphatase activity (HP:0004379)1.95712694
104Abnormal urine phosphate concentration (HP:0012599)1.94564524
105Milia (HP:0001056)1.94351376
106Abnormal gallbladder physiology (HP:0012438)1.93882686
107Cholecystitis (HP:0001082)1.93882686
108Elevated alkaline phosphatase (HP:0003155)1.93043647
109Increased purine levels (HP:0004368)1.92563266
110Hyperuricemia (HP:0002149)1.92563266
111Palpitations (HP:0001962)1.91707796
112Purpura (HP:0000979)1.89012764
113Gingival bleeding (HP:0000225)1.87539324
114Abnormality of eosinophils (HP:0001879)1.86733250
115Renal tubular dysfunction (HP:0000124)1.86070951
116Enlarged epiphyses (HP:0010580)1.85995030
117Thin bony cortex (HP:0002753)1.85942832
118Symptomatic seizures (HP:0011145)1.85057844
119Abnormal albumin level (HP:0012116)1.83112520
120Hypoalbuminemia (HP:0003073)1.83112520
121Woolly hair (HP:0002224)1.82496703
122Abnormality of the costochondral junction (HP:0000919)1.82283270
123Gastrointestinal infarctions (HP:0005244)1.81766581
124Pili torti (HP:0003777)1.80805544
125Nausea (HP:0002018)1.80792524
126Hyperbilirubinemia (HP:0002904)1.80405982
127Mitral stenosis (HP:0001718)1.79398992
128Gout (HP:0001997)1.78843579
129Hyperparathyroidism (HP:0000843)1.78538777
130Cerebral palsy (HP:0100021)1.77782288
131Menorrhagia (HP:0000132)1.77409956
132Abnormal biliary tract morphology (HP:0012440)1.76596828
133Skin nodule (HP:0200036)1.76164592
134Hepatocellular carcinoma (HP:0001402)1.75614346
135Abnormality of methionine metabolism (HP:0010901)1.75161584
136Thrombophlebitis (HP:0004418)1.74813152
137Hypoalphalipoproteinemia (HP:0003233)1.74729918
138Gingivitis (HP:0000230)1.74630891
139Abnormal platelet function (HP:0011869)1.73404531
140Impaired platelet aggregation (HP:0003540)1.73404531
141Hypoproteinemia (HP:0003075)1.73322208
142Ulnar bowing (HP:0003031)1.72870326
143Hypophosphatemia (HP:0002148)1.72268462
144Decreased central vision (HP:0007663)1.71639405
145Syncope (HP:0001279)1.71524928
146Hypotension (HP:0002615)1.69393265
147Eosinophilia (HP:0001880)1.67851321
148Lethargy (HP:0001254)1.67793531
149Peripheral demyelination (HP:0011096)1.67190011
150Pancreatitis (HP:0001733)1.65890972
151Polygenic inheritance (HP:0010982)1.65701056
152Pustule (HP:0200039)1.64755746
153Congenital sensorineural hearing impairment (HP:0008527)1.63477525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.57395583
2ACVR1B5.96835072
3FRK5.96065184
4AKT34.24216891
5GRK64.20472322
6MST1R3.78230409
7NME13.41279672
8LMTK23.32107652
9MAPK153.20012361
10PRKG23.10581350
11MAP3K103.04213649
12EPHA22.99033777
13RIPK12.59145348
14MUSK2.28099729
15WNK42.28093885
16MAP3K22.25570662
17ERN12.20083433
18PTK62.07461211
19NUAK12.05945888
20PIK3CG2.05530652
21MAP2K21.84294450
22STK101.83948255
23TESK21.73401649
24EPHB21.49433869
25MET1.42075395
26EPHA41.40931764
27FGFR31.38563731
28TAOK11.33519433
29KDR1.24840062
30BMX1.23667369
31TESK11.20192887
32DDR21.18466786
33BCKDK1.17933979
34STK391.10765166
35EPHB11.10000698
36PRKCI1.06183047
37RIPK41.03074646
38EPHA31.00072209
39MATK0.99329731
40MAP3K80.98221591
41MAP3K70.96541929
42KSR20.94801055
43TRIB30.93001515
44ZAP700.92116529
45BLK0.90722779
46SIK10.90622980
47CSF1R0.87857910
48PTK20.85704784
49LATS10.85317159
50PRKD20.84750638
51FER0.81101609
52TBK10.80305775
53CDK40.78812439
54MAP3K110.77617149
55PRKAA20.76873858
56TLK10.76675337
57SCYL20.73571321
58OXSR10.73084197
59MELK0.71562367
60MYLK0.71028152
61ERBB20.70425124
62CDK80.68354193
63TAOK30.66862419
64MAP2K60.65731325
65PAK40.65560147
66SYK0.63938998
67TNIK0.63819994
68LRRK20.63679810
69MAP3K90.63444233
70ICK0.62148775
71TTK0.59653858
72MAP3K10.58596173
73PRPF4B0.57016121
74NLK0.53552291
75MAP2K10.53485339
76PDPK10.50477752
77TEC0.49644565
78DAPK20.48746085
79MAP3K30.46952617
80CDK120.45974288
81PRKACA0.44672347
82MAPK110.44384614
83PAK30.41242116
84IGF1R0.40629900
85TYK20.40251924
86IKBKE0.40027094
87STK160.38527073
88STK380.38309279
89PBK0.38127739
90BTK0.36607808
91CDC42BPA0.36035197
92DYRK1B0.35612399
93MAP4K10.33677873
94PIK3CA0.33556600
95DMPK0.33320391
96CSK0.33245388
97TYRO30.33217914
98PIM10.32142934
99LYN0.31454446
100LIMK10.31425927
101PRKCQ0.31341964
102PDK10.31327093
103SRC0.31306294
104FGR0.30447829
105PRKG10.29953738
106MAP3K120.29748247
107AKT20.29671084
108PRKAA10.29619292
109PRKCA0.29556798
110PDK20.28512256
111PIM20.28361013
112PAK20.28325440
113MAPKAPK20.27710534
114PDGFRA0.26831805
115JAK10.26586621
116FYN0.25079450
117ABL20.24945345
118ITK0.24904834
119IRAK30.23874612
120CSNK1A10.21749527
121PRKCB0.21596335
122PRKACG0.21439608
123STK30.21343581
124PRKCD0.20982834
125ADRBK20.20812566
126CDK50.20728853
127STK110.20559301
128ROCK10.20268106
129PRKD30.19880652
130PRKD10.19757475
131MAP2K40.19619636
132CDK60.18629503
133ERBB40.15332063
134PAK10.14926209
135GRK10.14901626
136GSK3A0.11163052
137MAPK40.11113478
138CAMK2D0.09370833
139PRKCZ0.06099309
140ROCK20.05966035
141FGFR40.05954287
142EGFR0.05933225
143JAK20.05897261
144RET0.05214747

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.39921776
2Renin-angiotensin system_Homo sapiens_hsa046145.73048143
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.90325293
4Vitamin digestion and absorption_Homo sapiens_hsa049774.47263507
5Mineral absorption_Homo sapiens_hsa049783.77051929
6Caffeine metabolism_Homo sapiens_hsa002323.46860792
7Galactose metabolism_Homo sapiens_hsa000523.29025042
8Carbohydrate digestion and absorption_Homo sapiens_hsa049733.23912869
9Starch and sucrose metabolism_Homo sapiens_hsa005002.94416927
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82623762
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.77875362
12Complement and coagulation cascades_Homo sapiens_hsa046102.54756141
13Protein digestion and absorption_Homo sapiens_hsa049742.51182236
14Folate biosynthesis_Homo sapiens_hsa007902.01698976
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95518928
16Bile secretion_Homo sapiens_hsa049761.89093371
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86763468
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.85857769
19Tyrosine metabolism_Homo sapiens_hsa003501.79968167
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76558878
21Histidine metabolism_Homo sapiens_hsa003401.60741793
22PPAR signaling pathway_Homo sapiens_hsa033201.53991142
23Fructose and mannose metabolism_Homo sapiens_hsa000511.51970270
24Sulfur metabolism_Homo sapiens_hsa009201.48566937
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29292162
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28682776
27Glutathione metabolism_Homo sapiens_hsa004801.27309418
28Glycerolipid metabolism_Homo sapiens_hsa005611.25098282
29Tryptophan metabolism_Homo sapiens_hsa003801.23909214
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.22055612
31Arginine biosynthesis_Homo sapiens_hsa002201.12171371
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09837357
33Staphylococcus aureus infection_Homo sapiens_hsa051501.04291476
34Sulfur relay system_Homo sapiens_hsa041221.03912958
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03670721
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90355747
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86222543
38Arginine and proline metabolism_Homo sapiens_hsa003300.84433570
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83260589
40Nitrogen metabolism_Homo sapiens_hsa009100.83092878
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81525818
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80975491
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80192265
44ABC transporters_Homo sapiens_hsa020100.78257185
45Fatty acid degradation_Homo sapiens_hsa000710.77863260
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76853413
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71902643
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68981951
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.67484345
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65120189
51* Sphingolipid metabolism_Homo sapiens_hsa006000.64479288
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.62120119
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.61301310
54Other glycan degradation_Homo sapiens_hsa005110.58514087
55Retinol metabolism_Homo sapiens_hsa008300.56752911
56Type II diabetes mellitus_Homo sapiens_hsa049300.56579537
57Thyroid hormone synthesis_Homo sapiens_hsa049180.55930094
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53118044
59Pyruvate metabolism_Homo sapiens_hsa006200.51707712
60Vitamin B6 metabolism_Homo sapiens_hsa007500.50165098
61Carbon metabolism_Homo sapiens_hsa012000.46556866
62Tight junction_Homo sapiens_hsa045300.45866133
63Fatty acid biosynthesis_Homo sapiens_hsa000610.43695308
64Chemical carcinogenesis_Homo sapiens_hsa052040.42318843
65beta-Alanine metabolism_Homo sapiens_hsa004100.42024893
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39615760
67Prion diseases_Homo sapiens_hsa050200.38904891
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38035722
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37157928
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35499338
71Pentose phosphate pathway_Homo sapiens_hsa000300.34882827
72African trypanosomiasis_Homo sapiens_hsa051430.33527048
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.32988824
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30722415
75Renin secretion_Homo sapiens_hsa049240.30142382
76Gastric acid secretion_Homo sapiens_hsa049710.27140028
77Hematopoietic cell lineage_Homo sapiens_hsa046400.26224120
78Peroxisome_Homo sapiens_hsa041460.26040204
79Propanoate metabolism_Homo sapiens_hsa006400.24794123
80Pancreatic secretion_Homo sapiens_hsa049720.24620437
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.22724234
82One carbon pool by folate_Homo sapiens_hsa006700.22509698
83Salmonella infection_Homo sapiens_hsa051320.22408547
84Arachidonic acid metabolism_Homo sapiens_hsa005900.21166072
85Fatty acid metabolism_Homo sapiens_hsa012120.20527845
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.20348156
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19681599
88Lysine degradation_Homo sapiens_hsa003100.19462246
89Steroid biosynthesis_Homo sapiens_hsa001000.19233632
90Biosynthesis of amino acids_Homo sapiens_hsa012300.18964009
91Bladder cancer_Homo sapiens_hsa052190.18099901
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.17971784
93Pertussis_Homo sapiens_hsa051330.17803947
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17658077
95Linoleic acid metabolism_Homo sapiens_hsa005910.17429623
96Adherens junction_Homo sapiens_hsa045200.17380814
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17042836
98Insulin secretion_Homo sapiens_hsa049110.16931826
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16818484
100GnRH signaling pathway_Homo sapiens_hsa049120.16063661
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15273400
102* Metabolic pathways_Homo sapiens_hsa011000.15076700
103Hepatitis C_Homo sapiens_hsa051600.14168652
104Thyroid cancer_Homo sapiens_hsa052160.14117741
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.14019544
106Ether lipid metabolism_Homo sapiens_hsa005650.13818831
107Insulin resistance_Homo sapiens_hsa049310.12916090
108Glucagon signaling pathway_Homo sapiens_hsa049220.12495274
109Salivary secretion_Homo sapiens_hsa049700.12103795
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.11421511
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.07295559
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07151464
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.05914554
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.04965484
115Gap junction_Homo sapiens_hsa045400.04337324
116Butanoate metabolism_Homo sapiens_hsa006500.04272683
117Long-term depression_Homo sapiens_hsa047300.03881348
118Phenylalanine metabolism_Homo sapiens_hsa003600.03838362
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.02997466
120Inositol phosphate metabolism_Homo sapiens_hsa005620.02516823
121Choline metabolism in cancer_Homo sapiens_hsa052310.01759745
122Selenocompound metabolism_Homo sapiens_hsa004500.01458640
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.01371152
124Ovarian steroidogenesis_Homo sapiens_hsa049130.00475193
125AMPK signaling pathway_Homo sapiens_hsa041520.00266149
126Cocaine addiction_Homo sapiens_hsa05030-0.1264543
127Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0830793
128Fatty acid elongation_Homo sapiens_hsa00062-0.0643896
129Primary immunodeficiency_Homo sapiens_hsa05340-0.0503949
130Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.0141736
131VEGF signaling pathway_Homo sapiens_hsa04370-0.0018482

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