ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.93934561
2	regulation of mesoderm development (GO:2000380)	4.29139130
3	negative regulation of activin receptor signaling pathway (GO:0032926)	4.24389000
4	DNA double-strand break processing (GO:0000729)	4.10684375
5	tryptophan catabolic process (GO:0006569)	4.10055905
6	indole-containing compound catabolic process (GO:0042436)	4.10055905
7	indolalkylamine catabolic process (GO:0046218)	4.10055905
8	tryptophan metabolic process (GO:0006568)	4.06494978
9	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.05819252
10	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.05819252
11	regulation of translation, ncRNA-mediated (GO:0045974)	4.05819252
12	retinal cone cell development (GO:0046549)	4.04368914
13	endoderm formation (GO:0001706)	3.98855752
14	lysine catabolic process (GO:0006554)	3.95619574
15	lysine metabolic process (GO:0006553)	3.95619574
16	kidney morphogenesis (GO:0060993)	3.58044196
17	aspartate family amino acid catabolic process (GO:0009068)	3.50368245
18	somite rostral/caudal axis specification (GO:0032525)	3.49362320
19	indolalkylamine metabolic process (GO:0006586)	3.46540907
20	epithelial cilium movement (GO:0003351)	3.45263498
21	DNA integration (GO:0015074)	3.44982684
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.40974651
23	platelet dense granule organization (GO:0060155)	3.35880508
24	replication fork processing (GO:0031297)	3.34700433
25	regulation of activin receptor signaling pathway (GO:0032925)	3.30667345
26	kynurenine metabolic process (GO:0070189)	3.30393680
27	proteasome assembly (GO:0043248)	3.30257739
28	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.11152752
29	regulation of gene silencing by RNA (GO:0060966)	3.07867680
30	regulation of posttranscriptional gene silencing (GO:0060147)	3.07867680
31	regulation of gene silencing by miRNA (GO:0060964)	3.07867680
32	C4-dicarboxylate transport (GO:0015740)	3.04039947
33	establishment of protein localization to Golgi (GO:0072600)	3.02351283
34	regulation of helicase activity (GO:0051095)	3.01738907
35	synapsis (GO:0007129)	2.97961952
36	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.96599788
37	DNA catabolic process, exonucleolytic (GO:0000738)	2.96470462
38	rRNA methylation (GO:0031167)	2.96444297
39	chromatin remodeling at centromere (GO:0031055)	2.92911890
40	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.90181515
41	metaphase plate congression (GO:0051310)	2.89409981
42	cilium morphogenesis (GO:0060271)	2.89273492
43	CENP-A containing nucleosome assembly (GO:0034080)	2.87836582
44	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.87833513
45	protein targeting to Golgi (GO:0000042)	2.87503456
46	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.87012249
47	DNA damage response, detection of DNA damage (GO:0042769)	2.86717664
48	AMP metabolic process (GO:0046033)	2.85641981
49	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.83972930
50	histone exchange (GO:0043486)	2.83746210
51	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.82084296
52	regulation of mitotic spindle checkpoint (GO:1903504)	2.82084296
53	cilium movement (GO:0003341)	2.79672103
54	S-adenosylmethionine metabolic process (GO:0046500)	2.79124967
55	regulation of cofactor metabolic process (GO:0051193)	2.77183893
56	regulation of coenzyme metabolic process (GO:0051196)	2.77183893
57	limb bud formation (GO:0060174)	2.76204298
58	ADP metabolic process (GO:0046031)	2.75870876
59	anterior/posterior axis specification, embryo (GO:0008595)	2.75603345
60	behavioral response to nicotine (GO:0035095)	2.75259343
61	mitotic metaphase plate congression (GO:0007080)	2.74560348
62	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.74176008
63	rRNA modification (GO:0000154)	2.74113225
64	mitotic G2/M transition checkpoint (GO:0044818)	2.73900211
65	regulation of meiosis I (GO:0060631)	2.72139244
66	prenylation (GO:0097354)	2.67959371
67	protein prenylation (GO:0018342)	2.67959371
68	positive regulation of cardiac muscle cell proliferation (GO:0060045)	2.67728852
69	indole-containing compound metabolic process (GO:0042430)	2.63974583
70	resolution of meiotic recombination intermediates (GO:0000712)	2.63032904
71	L-fucose catabolic process (GO:0042355)	2.62897111
72	fucose catabolic process (GO:0019317)	2.62897111
73	L-fucose metabolic process (GO:0042354)	2.62897111
74	double-strand break repair via homologous recombination (GO:0000724)	2.62412153
75	protein polyglutamylation (GO:0018095)	2.61293951
76	negative regulation of DNA recombination (GO:0045910)	2.61121027
77	cardiac right ventricle morphogenesis (GO:0003215)	2.60783584
78	recombinational repair (GO:0000725)	2.60539702
79	reciprocal DNA recombination (GO:0035825)	2.60125839
80	reciprocal meiotic recombination (GO:0007131)	2.60125839
81	glyoxylate metabolic process (GO:0046487)	2.60054793
82	positive regulation of cardiac muscle tissue growth (GO:0055023)	2.58605498
83	eye photoreceptor cell development (GO:0042462)	2.58441229
84	cellular biogenic amine catabolic process (GO:0042402)	2.57381322
85	amine catabolic process (GO:0009310)	2.57381322
86	photoreceptor cell development (GO:0042461)	2.57168148
87	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.55768818
88	embryonic axis specification (GO:0000578)	2.55644634
89	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.55516479
90	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.55516479
91	intraciliary transport (GO:0042073)	2.54800748
92	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.54017879
93	DNA replication-dependent nucleosome organization (GO:0034723)	2.53944557
94	DNA replication-dependent nucleosome assembly (GO:0006335)	2.53944557
95	oogenesis (GO:0048477)	2.53228659
96	embryonic pattern specification (GO:0009880)	2.52733023
97	DNA ligation (GO:0006266)	2.52176491
98	regulation of centriole replication (GO:0046599)	2.51650988
99	protein K6-linked ubiquitination (GO:0085020)	2.51442031
100	isotype switching (GO:0045190)	2.51378326

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.92965635
2	VDR_22108803_ChIP-Seq_LS180_Human	3.43587492
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.41835106
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.00502585
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.73512684
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.61446024
7	P300_19829295_ChIP-Seq_ESCs_Human	2.56369885
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.55837971
9	EWS_26573619_Chip-Seq_HEK293_Human	2.49045176
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46620095
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.46371119
12	FUS_26573619_Chip-Seq_HEK293_Human	2.32493110
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.31072049
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.28213557
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26400001
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.15359989
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.13947865
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.09571667
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.07964986
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06007368
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.01041856
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.01021498
23	E2F7_22180533_ChIP-Seq_HELA_Human	1.77122031
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.75394892
25	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.71578331
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.71578331
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.70792578
28	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.70582672
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.70534450
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69735033
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68379461
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.68317694
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.66921751
34	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.65632877
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62776487
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59960705
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.59792320
38	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57538975
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56741938
40	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.56674002
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.54212757
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52282522
43	TCF4_22108803_ChIP-Seq_LS180_Human	1.50527631
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.49872652
45	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.48536496
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.47786413
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46760307
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45358930
49	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.44761327
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44498386
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44327770
52	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40385698
53	AR_25329375_ChIP-Seq_VCAP_Human	1.39820619
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39609603
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39609603
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.39487604
57	EZH2_22144423_ChIP-Seq_EOC_Human	1.35280665
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32813894
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30460750
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30460750
61	STAT3_23295773_ChIP-Seq_U87_Human	1.30036516
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28269313
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28174815
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27683814
65	TCF4_23295773_ChIP-Seq_U87_Human	1.27578389
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27236533
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27199978
68	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26786666
69	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21595032
70	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.21454862
71	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.18664492
72	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17798149
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17660454
74	CDX2_22108803_ChIP-Seq_LS180_Human	1.17048499
75	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.16180554
76	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13114031
77	AR_21572438_ChIP-Seq_LNCaP_Human	1.11829983
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09473512
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09473512
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09466409
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08276912
82	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04900329
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.03479586
84	VDR_23849224_ChIP-Seq_CD4+_Human	1.01798013
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99982882
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99298240
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97019955
88	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.96842588
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96492529
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96065453
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95127511
92	NCOR_22424771_ChIP-Seq_293T_Human	0.95071045
93	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.93567445
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.92678976
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92592257
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90152775
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.89492294
98	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89132283
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.88313942
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.87990937

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003890_abnormal_embryonic-extraembry	4.22598841
2	MP0006072_abnormal_retinal_apoptosis	3.56324326
3	MP0003136_yellow_coat_color	3.24602828
4	MP0005253_abnormal_eye_physiology	2.75415138
5	MP0009697_abnormal_copulation	2.71573218
6	MP0002102_abnormal_ear_morphology	2.52655686
7	MP0003880_abnormal_central_pattern	2.42338976
8	MP0003806_abnormal_nucleotide_metabolis	2.24949035
9	MP0001984_abnormal_olfaction	2.23454578
10	MP0010094_abnormal_chromosome_stability	2.13967344
11	MP0002638_abnormal_pupillary_reflex	2.12924874
12	MP0005551_abnormal_eye_electrophysiolog	1.96181601
13	MP0003119_abnormal_digestive_system	1.95743257
14	MP0004215_abnormal_myocardial_fiber	1.93406597
15	MP0006292_abnormal_olfactory_placode	1.89759234
16	MP0010030_abnormal_orbit_morphology	1.85894052
17	MP0005394_taste/olfaction_phenotype	1.83614842
18	MP0005499_abnormal_olfactory_system	1.83614842
19	MP0005248_abnormal_Harderian_gland	1.81070285
20	MP0008877_abnormal_DNA_methylation	1.80710092
21	MP0008058_abnormal_DNA_repair	1.79726814
22	MP0003195_calcinosis	1.79672416
23	MP0001486_abnormal_startle_reflex	1.76933329
24	MP0008004_abnormal_stomach_pH	1.73399363
25	MP0005171_absent_coat_pigmentation	1.64960911
26	MP0002653_abnormal_ependyma_morphology	1.61884194
27	MP0000569_abnormal_digit_pigmentation	1.61674567
28	MP0002736_abnormal_nociception_after	1.61617353
29	MP0004133_heterotaxia	1.60111622
30	MP0001529_abnormal_vocalization	1.59783563
31	MP0004084_abnormal_cardiac_muscle	1.58813953
32	MP0002233_abnormal_nose_morphology	1.56764785
33	MP0003937_abnormal_limbs/digits/tail_de	1.56528401
34	MP0003718_maternal_effect	1.53843598
35	MP0008789_abnormal_olfactory_epithelium	1.51985033
36	MP0002127_abnormal_cardiovascular_syste	1.49282376
37	MP0001986_abnormal_taste_sensitivity	1.48547674
38	MP0002837_dystrophic_cardiac_calcinosis	1.46670602
39	MP0005391_vision/eye_phenotype	1.45634734
40	MP0008872_abnormal_physiological_respon	1.45174627
41	MP0003567_abnormal_fetal_cardiomyocyte	1.43768210
42	MP0001485_abnormal_pinna_reflex	1.43711290
43	MP0002751_abnormal_autonomic_nervous	1.42161949
44	MP0001968_abnormal_touch/_nociception	1.40340280
45	MP0004264_abnormal_extraembryonic_tissu	1.36041071
46	MP0006054_spinal_hemorrhage	1.34342878
47	MP0003011_delayed_dark_adaptation	1.33999064
48	MP0001293_anophthalmia	1.33593426
49	MP0005410_abnormal_fertilization	1.32554278
50	MP0002938_white_spotting	1.31570306
51	MP0005174_abnormal_tail_pigmentation	1.27410900
52	MP0003385_abnormal_body_wall	1.22785212
53	MP0000372_irregular_coat_pigmentation	1.22615372
54	MP0004147_increased_porphyrin_level	1.19416551
55	MP0000749_muscle_degeneration	1.19296391
56	MP0009046_muscle_twitch	1.19160927
57	MP0002095_abnormal_skin_pigmentation	1.18202682
58	MP0005646_abnormal_pituitary_gland	1.12292024
59	MP0002090_abnormal_vision	1.10820863
60	MP0003646_muscle_fatigue	1.10641837
61	MP0004085_abnormal_heartbeat	1.06995783
62	MP0001929_abnormal_gametogenesis	1.04492321
63	MP0001764_abnormal_homeostasis	1.04333817
64	MP0002282_abnormal_trachea_morphology	1.02044687
65	MP0000538_abnormal_urinary_bladder	1.01643820
66	MP0003137_abnormal_impulse_conducting	1.01133703
67	MP0002111_abnormal_tail_morphology	1.00517039
68	MP0005330_cardiomyopathy	0.99931596
69	MP0005084_abnormal_gallbladder_morpholo	0.98897395
70	MP0001286_abnormal_eye_development	0.97975654
71	MP0000049_abnormal_middle_ear	0.97699464
72	MP0006036_abnormal_mitochondrial_physio	0.97335947
73	MP0003077_abnormal_cell_cycle	0.95670178
74	MP0004742_abnormal_vestibular_system	0.94046603
75	MP0002735_abnormal_chemical_nociception	0.92388756
76	MP0000427_abnormal_hair_cycle	0.92234809
77	MP0008995_early_reproductive_senescence	0.90958509
78	MP0002272_abnormal_nervous_system	0.90802076
79	MP0002752_abnormal_somatic_nervous	0.90507780
80	MP0004272_abnormal_basement_membrane	0.89731944
81	MP0001919_abnormal_reproductive_system	0.88288716
82	MP0008932_abnormal_embryonic_tissue	0.87786719
83	MP0003698_abnormal_male_reproductive	0.87365366
84	MP0009745_abnormal_behavioral_response	0.86829778
85	MP0001188_hyperpigmentation	0.86791289
86	MP0010386_abnormal_urinary_bladder	0.86685894
87	MP0005620_abnormal_muscle_contractility	0.85377067
88	MP0003938_abnormal_ear_development	0.83872186
89	MP0005195_abnormal_posterior_eye	0.80067247
90	MP0002067_abnormal_sensory_capabilities	0.79332655
91	MP0000653_abnormal_sex_gland	0.77419785
92	MP0000631_abnormal_neuroendocrine_gland	0.77305205
93	MP0008775_abnormal_heart_ventricle	0.76679827
94	MP0002184_abnormal_innervation	0.76625731
95	MP0002210_abnormal_sex_determination	0.76315100
96	MP0001501_abnormal_sleep_pattern	0.76131960
97	MP0001324_abnormal_eye_pigmentation	0.74800813
98	MP0005647_abnormal_sex_gland	0.74269851
99	MP0001145_abnormal_male_reproductive	0.74090840
100	MP0005167_abnormal_blood-brain_barrier	0.73335865

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	4.12183313
2	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.50008316
3	Pancreatic cysts (HP:0001737)	3.48111182
4	Colon cancer (HP:0003003)	3.46582640
5	Abnormality of the ileum (HP:0001549)	3.35525272
6	Aqueductal stenosis (HP:0002410)	3.27707954
7	Pancreatic fibrosis (HP:0100732)	3.27277382
8	Meckel diverticulum (HP:0002245)	3.27275930
9	Absent radius (HP:0003974)	3.23689774
10	Abnormality of the parathyroid morphology (HP:0011766)	3.17825547
11	Absent forearm bone (HP:0003953)	3.13692046
12	Aplasia involving forearm bones (HP:0009822)	3.13692046
13	Progressive inability to walk (HP:0002505)	3.09090505
14	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.06077402
15	Chromsome breakage (HP:0040012)	3.01109295
16	Congenital malformation of the right heart (HP:0011723)	2.97092564
17	Double outlet right ventricle (HP:0001719)	2.97092564
18	Congenital stationary night blindness (HP:0007642)	2.80575101
19	Anophthalmia (HP:0000528)	2.75452292
20	Abolished electroretinogram (ERG) (HP:0000550)	2.70821242
21	Oligodactyly (hands) (HP:0001180)	2.65677262
22	True hermaphroditism (HP:0010459)	2.65153456
23	Abnormality of chromosome stability (HP:0003220)	2.56129473
24	Prostate neoplasm (HP:0100787)	2.54874640
25	Inability to walk (HP:0002540)	2.49674761
26	Stomach cancer (HP:0012126)	2.48164207
27	Abnormality of the duodenum (HP:0002246)	2.44305971
28	Bifid tongue (HP:0010297)	2.44080318
29	Carpal bone hypoplasia (HP:0001498)	2.42831506
30	Tubulointerstitial nephritis (HP:0001970)	2.40236943
31	Gastrointestinal atresia (HP:0002589)	2.39710411
32	Bile duct proliferation (HP:0001408)	2.37172043
33	Abnormal biliary tract physiology (HP:0012439)	2.37172043
34	Abnormality of the preputium (HP:0100587)	2.35942896
35	Supernumerary spleens (HP:0009799)	2.35267968
36	Small intestinal stenosis (HP:0012848)	2.31161551
37	Duodenal stenosis (HP:0100867)	2.31161551
38	Nephronophthisis (HP:0000090)	2.30541073
39	Dyschromatopsia (HP:0007641)	2.28347539
40	Anencephaly (HP:0002323)	2.26422455
41	Methylmalonic acidemia (HP:0002912)	2.25007582
42	Abnormality of the renal cortex (HP:0011035)	2.23665787
43	Enlarged kidneys (HP:0000105)	2.22576419
44	Chronic hepatic failure (HP:0100626)	2.21463928
45	Abnormality of the renal medulla (HP:0100957)	2.19687696
46	Optic nerve hypoplasia (HP:0000609)	2.19449149
47	Abnormal lung lobation (HP:0002101)	2.18837175
48	Medial flaring of the eyebrow (HP:0010747)	2.18130156
49	Abnormality of lateral ventricle (HP:0030047)	2.16561715
50	Triphalangeal thumb (HP:0001199)	2.16328972
51	Sloping forehead (HP:0000340)	2.15316772
52	Genital tract atresia (HP:0001827)	2.15020934
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.11779056
54	Clubbing of toes (HP:0100760)	2.11702607
55	Esophageal atresia (HP:0002032)	2.11447498
56	Abnormality of methionine metabolism (HP:0010901)	2.11394940
57	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.11317135
58	Hyperglycinemia (HP:0002154)	2.11296562
59	Abnormality of midbrain morphology (HP:0002418)	2.05388023
60	Molar tooth sign on MRI (HP:0002419)	2.05388023
61	Renal cortical cysts (HP:0000803)	2.05045013
62	Delayed CNS myelination (HP:0002188)	2.03338780
63	Vaginal atresia (HP:0000148)	1.99066598
64	Horseshoe kidney (HP:0000085)	1.98435730
65	Renal hypoplasia (HP:0000089)	1.95891780
66	Cystic liver disease (HP:0006706)	1.94166103
67	Abnormality of the labia minora (HP:0012880)	1.93022550
68	Atonic seizures (HP:0010819)	1.92596939
69	Methylmalonic aciduria (HP:0012120)	1.91614773
70	Decreased central vision (HP:0007663)	1.91126467
71	Ependymoma (HP:0002888)	1.90505735
72	Abnormality of B cell number (HP:0010975)	1.90440599
73	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.89573660
74	Chin dimple (HP:0010751)	1.89539331
75	Pendular nystagmus (HP:0012043)	1.87855032
76	Septo-optic dysplasia (HP:0100842)	1.87707509
77	Oligohydramnios (HP:0001562)	1.86963919
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86102387
79	Congenital hepatic fibrosis (HP:0002612)	1.85960570
80	Abnormal pancreas size (HP:0012094)	1.84569059
81	Cupped ear (HP:0000378)	1.81457069
82	Oligodactyly (HP:0012165)	1.81313534
83	Preaxial foot polydactyly (HP:0001841)	1.81229618
84	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80617702
85	Small hand (HP:0200055)	1.80502580
86	Vitreoretinal degeneration (HP:0000655)	1.79503889
87	Abnormality of the carotid arteries (HP:0005344)	1.79219972
88	Congenital sensorineural hearing impairment (HP:0008527)	1.78355653
89	Preaxial hand polydactyly (HP:0001177)	1.76805782
90	Abdominal situs inversus (HP:0003363)	1.76538990
91	Abnormality of abdominal situs (HP:0011620)	1.76538990
92	Astigmatism (HP:0000483)	1.76472617
93	Abnormality of the pubic bones (HP:0003172)	1.75563881
94	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.75034742
95	Congenital primary aphakia (HP:0007707)	1.72702812
96	Hemivertebrae (HP:0002937)	1.72353974
97	Agnosia (HP:0010524)	1.72263694
98	Astrocytoma (HP:0009592)	1.71999281
99	Abnormality of the astrocytes (HP:0100707)	1.71999281
100	Febrile seizures (HP:0002373)	1.71841916

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.03436504
2	PINK1	3.75905215
3	BMPR1B	3.45720537
4	GRK1	3.33860268
5	FRK	2.80688986
6	NUAK1	2.79526526
7	TNIK	2.53859461
8	TESK2	2.48805588
9	ZAK	2.42155134
10	PBK	2.38315385
11	LATS1	2.28178566
12	WNK3	2.24097678
13	ERBB4	2.22176685
14	TAOK3	2.20917190
15	MST4	2.10820352
16	FLT3	1.75689220
17	STK38L	1.62740551
18	PKN2	1.61543569
19	PDK2	1.57502754
20	OBSCN	1.57066838
21	PLK4	1.56558504
22	MAP2K7	1.55870634
23	MKNK2	1.53387113
24	INSRR	1.48109474
25	NEK1	1.47721451
26	MAP3K4	1.45029683
27	TGFBR1	1.44334026
28	EIF2AK3	1.43851382
29	TRIM28	1.36669795
30	MARK3	1.33217510
31	PTK2B	1.19404957
32	CSNK1G1	1.13452163
33	CSNK1A1L	1.11186188
34	WEE1	1.09157338
35	MAPK13	1.07814443
36	PLK2	1.07503793
37	MAP4K2	1.06150423
38	TLK1	1.05869397
39	SRPK1	1.05570480
40	ADRBK2	1.04892540
41	CSNK1G3	1.04394725
42	BUB1	1.02837450
43	CCNB1	1.00705618
44	VRK2	1.00416005
45	MKNK1	1.00248341
46	PNCK	1.00175392
47	CSNK1G2	0.96320434
48	BRSK2	0.95448006
49	PLK3	0.93842563
50	TGFBR2	0.92097478
51	MAP3K12	0.90183105
52	PLK1	0.87564992
53	DYRK2	0.87427354
54	EPHA4	0.81968020
55	TSSK6	0.81860645
56	STK39	0.81505644
57	VRK1	0.77624741
58	OXSR1	0.77447416
59	BCR	0.76970655
60	NLK	0.76612444
61	NME1	0.69771316
62	NEK2	0.67885729
63	DAPK1	0.65226934
64	TNK2	0.64764995
65	CDK3	0.60235569
66	MYLK	0.59783855
67	PRKD3	0.59499330
68	CDC7	0.57124938
69	ATM	0.57056621
70	TIE1	0.53258147
71	ERBB3	0.53194223
72	CHEK2	0.53186067
73	ATR	0.50957648
74	TTK	0.50460217
75	PRKCQ	0.50334678
76	MUSK	0.48565281
77	ADRBK1	0.48187618
78	PRKCG	0.46811194
79	MELK	0.46176286
80	DYRK3	0.46053771
81	EIF2AK2	0.45269069
82	PAK3	0.44031349
83	GRK5	0.42963298
84	SIK3	0.42899566
85	RPS6KA4	0.41889420
86	MINK1	0.39774613
87	BCKDK	0.39003917
88	CSNK1A1	0.38146146
89	PRKCE	0.38065510
90	STK16	0.33796701
91	MAP3K5	0.32904688
92	AURKB	0.31666542
93	STK3	0.30239198
94	PIK3CA	0.30148737
95	FGFR1	0.27150468
96	CAMK2A	0.26918331
97	NTRK2	0.26234109
98	CSNK2A1	0.24957857
99	GRK7	0.24707536
100	ROCK1	0.24450601

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.87172868
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.85552824
3	Mismatch repair_Homo sapiens_hsa03430	2.66938647
4	Propanoate metabolism_Homo sapiens_hsa00640	2.58270288
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.54525979
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.40160548
7	Homologous recombination_Homo sapiens_hsa03440	2.36088638
8	Butanoate metabolism_Homo sapiens_hsa00650	2.36069519
9	Olfactory transduction_Homo sapiens_hsa04740	2.19360739
10	DNA replication_Homo sapiens_hsa03030	2.15729263
11	Protein export_Homo sapiens_hsa03060	2.03810837
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.00167435
13	Proteasome_Homo sapiens_hsa03050	1.98479322
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.86774107
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.84373400
16	RNA degradation_Homo sapiens_hsa03018	1.78671921
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.73970016
18	One carbon pool by folate_Homo sapiens_hsa00670	1.68105778
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.55875636
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.51800327
21	RNA polymerase_Homo sapiens_hsa03020	1.49655636
22	Fatty acid degradation_Homo sapiens_hsa00071	1.38038545
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.36695024
24	Pyruvate metabolism_Homo sapiens_hsa00620	1.36126623
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35733065
26	Taste transduction_Homo sapiens_hsa04742	1.34127573
27	Base excision repair_Homo sapiens_hsa03410	1.33781528
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29586734
29	Fatty acid elongation_Homo sapiens_hsa00062	1.26046475
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.26037311
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.25776563
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23653319
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.22806123
34	Parkinsons disease_Homo sapiens_hsa05012	1.21209978
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.20000931
36	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.19599444
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.15145799
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.14075397
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.13705885
40	RNA transport_Homo sapiens_hsa03013	1.10744680
41	Basal transcription factors_Homo sapiens_hsa03022	1.10249424
42	Lysine degradation_Homo sapiens_hsa00310	1.10164084
43	Purine metabolism_Homo sapiens_hsa00230	1.09588398
44	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.08872438
45	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.08677814
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.07181717
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06637804
48	Fatty acid metabolism_Homo sapiens_hsa01212	1.04762279
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.04623809
50	Nucleotide excision repair_Homo sapiens_hsa03420	1.04268756
51	Peroxisome_Homo sapiens_hsa04146	1.01980366
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99105259
53	Calcium signaling pathway_Homo sapiens_hsa04020	0.98425576
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.96090626
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.95531825
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.95199630
57	Retinol metabolism_Homo sapiens_hsa00830	0.94240729
58	Circadian entrainment_Homo sapiens_hsa04713	0.92514691
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.92141283
60	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.91338441
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.91166751
62	Glutathione metabolism_Homo sapiens_hsa00480	0.91028547
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85763832
64	Circadian rhythm_Homo sapiens_hsa04710	0.84360156
65	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84002168
66	Nicotine addiction_Homo sapiens_hsa05033	0.83066336
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81510823
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.79137173
69	Cell cycle_Homo sapiens_hsa04110	0.77481424
70	GABAergic synapse_Homo sapiens_hsa04727	0.76481676
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75669369
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75400327
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75069686
74	Huntingtons disease_Homo sapiens_hsa05016	0.71170381
75	Oocyte meiosis_Homo sapiens_hsa04114	0.70597260
76	Caffeine metabolism_Homo sapiens_hsa00232	0.69351586
77	Metabolic pathways_Homo sapiens_hsa01100	0.69183990
78	Basal cell carcinoma_Homo sapiens_hsa05217	0.65432053
79	Wnt signaling pathway_Homo sapiens_hsa04310	0.64734128
80	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.63385459
81	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.61330036
82	Salivary secretion_Homo sapiens_hsa04970	0.60883772
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60678596
84	Serotonergic synapse_Homo sapiens_hsa04726	0.57458473
85	Carbon metabolism_Homo sapiens_hsa01200	0.57152474
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.56802012
87	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.55326887
88	Regulation of autophagy_Homo sapiens_hsa04140	0.55051679
89	Gastric acid secretion_Homo sapiens_hsa04971	0.53645878
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.49852195
91	Alzheimers disease_Homo sapiens_hsa05010	0.45818062
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44305536
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43985377
94	Spliceosome_Homo sapiens_hsa03040	0.42974537
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.41125869
96	Morphine addiction_Homo sapiens_hsa05032	0.38015562
97	Renin secretion_Homo sapiens_hsa04924	0.35520214
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35040690
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.34202623
100	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.34053940

ENPP7P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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