ENPP7P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to nerve growth factor (GO:1990089)6.98879887
2cellular response to nerve growth factor stimulus (GO:1990090)6.98879887
3establishment of nucleus localization (GO:0040023)6.69162857
4regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)6.57191207
5cerebral cortex radially oriented cell migration (GO:0021799)6.48833185
6microtubule depolymerization (GO:0007019)5.97328465
7regulation of heat generation (GO:0031650)5.44401428
8intracellular lipid transport (GO:0032365)5.36443847
9protein targeting to Golgi (GO:0000042)5.18124699
10establishment of protein localization to Golgi (GO:0072600)5.14798324
11myelination in peripheral nervous system (GO:0022011)5.05486088
12peripheral nervous system axon ensheathment (GO:0032292)5.05486088
13retrograde transport, vesicle recycling within Golgi (GO:0000301)5.03179454
14negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.98748525
15regulation of actin nucleation (GO:0051125)4.92781293
16microtubule polymerization or depolymerization (GO:0031109)4.52781044
17oxidative phosphorylation (GO:0006119)4.48347333
18protein localization to Golgi apparatus (GO:0034067)4.15883471
19Rac protein signal transduction (GO:0016601)4.09161970
20positive regulation of cardiac muscle cell differentiation (GO:2000727)4.06089187
21positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.99297510
22regulation of NFAT protein import into nucleus (GO:0051532)3.99271107
23sperm motility (GO:0030317)3.97155720
24cerebral cortex cell migration (GO:0021795)3.95762922
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.93546251
26replication fork processing (GO:0031297)3.93423104
27centriole replication (GO:0007099)3.90552789
28rRNA methylation (GO:0031167)3.88276797
29germ cell migration (GO:0008354)3.80180044
30nucleoside diphosphate catabolic process (GO:0009134)3.79255574
31sister chromatid cohesion (GO:0007062)3.78208834
32DNA-dependent DNA replication (GO:0006261)3.74514670
33substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.72359926
34substrate-independent telencephalic tangential migration (GO:0021826)3.72359926
35nucleus localization (GO:0051647)3.66790962
36positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.63651042
37limb bud formation (GO:0060174)3.59487274
38seminiferous tubule development (GO:0072520)3.55964484
39protein polyglutamylation (GO:0018095)3.54651102
40rRNA modification (GO:0000154)3.46723617
41ether lipid metabolic process (GO:0046485)3.45338871
42preassembly of GPI anchor in ER membrane (GO:0016254)3.43633389
43L-ascorbic acid metabolic process (GO:0019852)3.26990082
44pericardium development (GO:0060039)3.26116199
45glycerol ether metabolic process (GO:0006662)3.24539193
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22058042
47head development (GO:0060322)3.21481371
48tachykinin receptor signaling pathway (GO:0007217)3.17261969
49regulation of cilium movement (GO:0003352)3.15630221
50negative regulation of receptor activity (GO:2000272)3.13926868
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13323995
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.13004768
53negative regulation of norepinephrine secretion (GO:0010700)3.11605669
54nuclear pore complex assembly (GO:0051292)3.11293809
55regulation of protein kinase A signaling (GO:0010738)3.11242380
56positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.05684391
57positive regulation of SMAD protein import into nucleus (GO:0060391)3.01879044
58lateral ventricle development (GO:0021670)3.00758518
59negative regulation of multicellular organism growth (GO:0040015)3.00753124
60regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.99551132
61ether metabolic process (GO:0018904)2.98320456
62receptor recycling (GO:0001881)2.97788475
63epithelial cilium movement (GO:0003351)2.97465832
64polyol transport (GO:0015791)2.97149892
65negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.93187783
66GPI anchor metabolic process (GO:0006505)2.90938123
67C-terminal protein lipidation (GO:0006501)2.89682314
68regulation of transcription from RNA polymerase III promoter (GO:0006359)2.88757061
69resolution of meiotic recombination intermediates (GO:0000712)2.86562992
70microtubule severing (GO:0051013)2.85151296
71embryonic pattern specification (GO:0009880)2.85134358
72fusion of sperm to egg plasma membrane (GO:0007342)2.84107670
73regulation of centriole replication (GO:0046599)2.82124647
74atrial cardiac muscle cell action potential (GO:0086014)2.81804298
75astrocyte development (GO:0014002)2.78623369
76protein targeting to vacuole (GO:0006623)2.78224657
77protein targeting to lysosome (GO:0006622)2.78224657
78establishment of protein localization to vacuole (GO:0072666)2.78224657
79neuronal action potential propagation (GO:0019227)2.76224117
80osteoblast development (GO:0002076)2.75287727
81centriole assembly (GO:0098534)2.71509099
82C-terminal protein amino acid modification (GO:0018410)2.70839808
83axoneme assembly (GO:0035082)2.70738275
84negative regulation of protein tyrosine kinase activity (GO:0061099)2.68933178
85regulation of ARF GTPase activity (GO:0032312)2.67567514
86positive regulation of heart rate (GO:0010460)2.66218781
87multicellular organism reproduction (GO:0032504)2.65501034
88positive regulation of muscle hypertrophy (GO:0014742)2.64810916
89positive regulation of cardiac muscle hypertrophy (GO:0010613)2.64810916
90regulation of uterine smooth muscle contraction (GO:0070472)2.62125468
91pharyngeal system development (GO:0060037)2.60729659
92intraciliary transport (GO:0042073)2.60646575
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59611614
94regulation of mesoderm development (GO:2000380)2.57513321
95dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.56792484
96pore complex assembly (GO:0046931)2.56154289
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54626621
98adaptation of signaling pathway (GO:0023058)2.53824885
99cilium movement (GO:0003341)2.53677089
100protein localization to endosome (GO:0036010)10.1489267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.46841444
2GBX2_23144817_ChIP-Seq_PC3_Human4.50833077
3EZH2_22144423_ChIP-Seq_EOC_Human3.33441610
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.29915238
5TAF15_26573619_Chip-Seq_HEK293_Human3.15192417
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.12352150
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.85529019
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.57773888
9EWS_26573619_Chip-Seq_HEK293_Human2.56447744
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50596033
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43023364
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42352214
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34719837
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33222154
15FUS_26573619_Chip-Seq_HEK293_Human2.25121866
16P300_19829295_ChIP-Seq_ESCs_Human2.16744124
17IGF1R_20145208_ChIP-Seq_DFB_Human2.16327139
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08571106
19VDR_22108803_ChIP-Seq_LS180_Human2.05579845
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.04871387
21ZNF274_21170338_ChIP-Seq_K562_Hela2.04604366
22ER_23166858_ChIP-Seq_MCF-7_Human2.01891528
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00717541
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.96211195
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89003171
26CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80946191
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76356993
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75437578
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72107436
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69421443
31CBP_20019798_ChIP-Seq_JUKART_Human1.69421443
32SMAD4_21799915_ChIP-Seq_A2780_Human1.69380507
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67243105
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65064859
35STAT3_23295773_ChIP-Seq_U87_Human1.64962758
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62105990
37TP53_16413492_ChIP-PET_HCT116_Human1.60522795
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60456766
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58397087
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.54705908
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.54669061
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50518377
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.46170377
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.45889183
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.45206952
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.45190298
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41322728
48TCF4_23295773_ChIP-Seq_U87_Human1.41082420
49SOX2_19829295_ChIP-Seq_ESCs_Human1.37750924
50NANOG_19829295_ChIP-Seq_ESCs_Human1.37750924
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36257068
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36257068
53AR_25329375_ChIP-Seq_VCAP_Human1.34314514
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32785333
55BCAT_22108803_ChIP-Seq_LS180_Human1.32366057
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.32241991
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31290513
58TCF4_22108803_ChIP-Seq_LS180_Human1.29372774
59P53_22387025_ChIP-Seq_ESCs_Mouse1.28783536
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27904302
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26724367
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22854412
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22559796
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.21969714
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.18102565
66TP53_18474530_ChIP-ChIP_U2OS_Human1.17484588
67RUNX2_22187159_ChIP-Seq_PCA_Human1.17053804
68IRF1_19129219_ChIP-ChIP_H3396_Human1.15255330
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.14836750
70ETV1_20927104_ChIP-Seq_GIST48_Human1.14438487
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12800089
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12240113
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.11632560
74TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11525149
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07337721
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07337721
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.06316812
78TBL1_22424771_ChIP-Seq_293T_Human1.05925249
79KDM2B_26808549_Chip-Seq_REH_Human1.05886609
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05166009
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04993034
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.03965079
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03698168
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.02401761
85OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02270811
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01322779
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01180171
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00942900
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.99742906
90TP53_22573176_ChIP-Seq_HFKS_Human0.99479191
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99233331
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98989030
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98851026
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97889129
95CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97380225
96CTCF_18555785_Chip-Seq_ESCs_Mouse0.97223335
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.97178121
98NFYB_21822215_ChIP-Seq_K562_Human0.96930117
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96871413
100CDX2_22108803_ChIP-Seq_LS180_Human0.95130614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology3.80427747
2MP0002249_abnormal_larynx_morphology3.13704874
3MP0002653_abnormal_ependyma_morphology3.10114784
4MP0002233_abnormal_nose_morphology2.84218658
5MP0004043_abnormal_pH_regulation2.81752872
6MP0000049_abnormal_middle_ear2.58830740
7MP0001984_abnormal_olfaction2.57195711
8MP0005410_abnormal_fertilization2.56295292
9MP0002102_abnormal_ear_morphology2.20811304
10MP0001293_anophthalmia2.10660179
11MP0001485_abnormal_pinna_reflex2.07951610
12MP0004484_altered_response_of2.05767271
13MP0003890_abnormal_embryonic-extraembry2.01624520
14MP0008995_early_reproductive_senescence1.88405381
15MP0000778_abnormal_nervous_system1.87585721
16MP0005394_taste/olfaction_phenotype1.84899847
17MP0005499_abnormal_olfactory_system1.84899847
18MP0000631_abnormal_neuroendocrine_gland1.82784495
19MP0004859_abnormal_synaptic_plasticity1.78939845
20MP0001486_abnormal_startle_reflex1.72172982
21MP0002751_abnormal_autonomic_nervous1.71480842
22MP0008789_abnormal_olfactory_epithelium1.71195204
23MP0008004_abnormal_stomach_pH1.68838554
24MP0000427_abnormal_hair_cycle1.66054592
25MP0006054_spinal_hemorrhage1.63921153
26MP0001529_abnormal_vocalization1.62936407
27MP0003935_abnormal_craniofacial_develop1.62846982
28MP0000647_abnormal_sebaceous_gland1.61851098
29MP0003698_abnormal_male_reproductive1.60122218
30MP0003119_abnormal_digestive_system1.60100825
31MP0000613_abnormal_salivary_gland1.59452826
32MP0002697_abnormal_eye_size1.58160396
33MP0003755_abnormal_palate_morphology1.55924663
34MP0006292_abnormal_olfactory_placode1.53350402
35MP0002938_white_spotting1.52145745
36MP0005187_abnormal_penis_morphology1.51621592
37MP0001286_abnormal_eye_development1.47045553
38MP0009697_abnormal_copulation1.43149934
39MP0008260_abnormal_autophagy1.41968726
40MP0001929_abnormal_gametogenesis1.38974727
41MP0004742_abnormal_vestibular_system1.35170393
42MP0001299_abnormal_eye_distance/1.33829314
43MP0005253_abnormal_eye_physiology1.32951500
44MP0005551_abnormal_eye_electrophysiolog1.32564192
45MP0003937_abnormal_limbs/digits/tail_de1.31021569
46MP0009250_abnormal_appendicular_skeleto1.29705676
47MP0000762_abnormal_tongue_morphology1.28345089
48MP0002184_abnormal_innervation1.24924904
49MP0002736_abnormal_nociception_after1.24556855
50MP0003938_abnormal_ear_development1.24360439
51MP0009046_muscle_twitch1.23242470
52MP0002109_abnormal_limb_morphology1.21580975
53MP0005377_hearing/vestibular/ear_phenot1.20074803
54MP0003878_abnormal_ear_physiology1.20074803
55MP0004147_increased_porphyrin_level1.19461296
56MP0003942_abnormal_urinary_system1.15249884
57MP0010030_abnormal_orbit_morphology1.14947202
58MP0008872_abnormal_physiological_respon1.13111296
59MP0008775_abnormal_heart_ventricle1.11494809
60MP0003385_abnormal_body_wall1.11052416
61MP0001986_abnormal_taste_sensitivity1.10065812
62MP0002116_abnormal_craniofacial_bone1.07446377
63MP0003122_maternal_imprinting1.05958104
64MP0002177_abnormal_outer_ear1.04243278
65MP0002282_abnormal_trachea_morphology1.03805646
66MP0000163_abnormal_cartilage_morphology1.02893049
67MP0001764_abnormal_homeostasis1.02811329
68MP0002272_abnormal_nervous_system1.02451429
69MP0003880_abnormal_central_pattern1.01710743
70MP0004782_abnormal_surfactant_physiolog1.01494882
71MP0002210_abnormal_sex_determination0.99725959
72MP0004133_heterotaxia0.98671798
73MP0000653_abnormal_sex_gland0.96008586
74MP0005645_abnormal_hypothalamus_physiol0.94977578
75MP0000534_abnormal_ureter_morphology0.94038800
76MP0003137_abnormal_impulse_conducting0.93931022
77MP0001145_abnormal_male_reproductive0.93804456
78MP0002734_abnormal_mechanical_nocicepti0.93563064
79MP0000383_abnormal_hair_follicle0.89397487
80MP0004085_abnormal_heartbeat0.89379501
81MP0006035_abnormal_mitochondrial_morpho0.88369745
82MP0001968_abnormal_touch/_nociception0.88242066
83MP0005391_vision/eye_phenotype0.87268819
84MP0001963_abnormal_hearing_physiology0.86954683
85MP0003941_abnormal_skin_development0.86480422
86MP0000428_abnormal_craniofacial_morphol0.85662556
87MP0003718_maternal_effect0.85128921
88MP0002152_abnormal_brain_morphology0.84548186
89MP0004811_abnormal_neuron_physiology0.83958905
90MP0002572_abnormal_emotion/affect_behav0.83045815
91MP0001270_distended_abdomen0.82919607
92MP0002127_abnormal_cardiovascular_syste0.82404579
93MP0003861_abnormal_nervous_system0.81556962
94MP0003567_abnormal_fetal_cardiomyocyte0.80076732
95MP0000432_abnormal_head_morphology0.79347908
96MP0005646_abnormal_pituitary_gland0.79200292
97MP0002752_abnormal_somatic_nervous0.76823456
98MP0009745_abnormal_behavioral_response0.75107365
99MP0002161_abnormal_fertility/fecundity0.73809628
100MP0000230_abnormal_systemic_arterial0.73665221

Predicted human phenotypes

RankGene SetZ-score
1Long nose (HP:0003189)5.18578925
2Conical tooth (HP:0000698)4.86314803
3Reduced antithrombin III activity (HP:0001976)4.84396711
4Broad-based gait (HP:0002136)4.35535078
5Progressive inability to walk (HP:0002505)3.75951195
6Type I transferrin isoform profile (HP:0003642)3.74571399
7Neoplasm of the oral cavity (HP:0100649)3.66446011
8Hyperventilation (HP:0002883)3.35280911
9Bifid tongue (HP:0010297)3.29628215
10Abnormality of lateral ventricle (HP:0030047)3.20677952
11Preaxial foot polydactyly (HP:0001841)3.15977986
12Pancreatic cysts (HP:0001737)3.14651564
13Nephronophthisis (HP:0000090)3.13793106
14Inability to walk (HP:0002540)3.11639829
15Abdominal situs inversus (HP:0003363)3.05453962
16Abnormality of abdominal situs (HP:0011620)3.05453962
17Bulbous nose (HP:0000414)3.04613804
18Abnormality of the labia minora (HP:0012880)3.00128679
19Abnormality of the intrinsic pathway (HP:0010989)2.85764667
20Abnormality of the pubic bones (HP:0003172)2.85567650
21Abnormality of the parathyroid morphology (HP:0011766)2.82224398
22Molar tooth sign on MRI (HP:0002419)2.79511408
23Abnormality of midbrain morphology (HP:0002418)2.79511408
24Bilateral microphthalmos (HP:0007633)2.73497076
25Chronic hepatic failure (HP:0100626)2.70817035
26Absent speech (HP:0001344)2.69082920
27Abnormal protein glycosylation (HP:0012346)2.68844704
28Abnormal glycosylation (HP:0012345)2.68844704
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68844704
30Abnormal protein N-linked glycosylation (HP:0012347)2.68844704
31Absent eyebrow (HP:0002223)2.67095734
32Pancreatic fibrosis (HP:0100732)2.66547385
33Hypoplastic ischia (HP:0003175)2.58258925
34Abnormality of macular pigmentation (HP:0008002)2.52648207
35Attenuation of retinal blood vessels (HP:0007843)2.50388940
36True hermaphroditism (HP:0010459)2.45188418
37Capillary hemangiomas (HP:0005306)2.44744676
38Tubulointerstitial nephritis (HP:0001970)2.44548212
39Anal stenosis (HP:0002025)2.43909804
40Acute lymphatic leukemia (HP:0006721)2.41760594
41Oligodontia (HP:0000677)2.40579042
42Abnormality of the ischium (HP:0003174)2.40032433
43Amyotrophic lateral sclerosis (HP:0007354)2.39330427
44Abnormality of alanine metabolism (HP:0010916)2.36054679
45Hyperalaninemia (HP:0003348)2.36054679
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36054679
47Lissencephaly (HP:0001339)2.32369213
48Cystic liver disease (HP:0006706)2.32158987
49Abnormality of the renal medulla (HP:0100957)2.26333640
50Vaginal atresia (HP:0000148)2.22927440
51Pancreatic islet-cell hyperplasia (HP:0004510)2.21845274
52Anophthalmia (HP:0000528)2.20780149
53Genital tract atresia (HP:0001827)2.18878584
54Medial flaring of the eyebrow (HP:0010747)2.18289458
55Morphological abnormality of the middle ear (HP:0008609)2.16673759
56Increased mean platelet volume (HP:0011877)2.11010401
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10120675
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09584040
59Focal motor seizures (HP:0011153)2.07781050
60Absent/shortened dynein arms (HP:0200106)2.05853037
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.05853037
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05586158
63Short 4th metacarpal (HP:0010044)2.05586158
64Exotropia (HP:0000577)2.03752753
65Postaxial foot polydactyly (HP:0001830)2.03465008
66Bell-shaped thorax (HP:0001591)2.00037824
67Chin dimple (HP:0010751)1.99700992
68Myelomeningocele (HP:0002475)1.97277490
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.96487062
70Abnormal lung lobation (HP:0002101)1.95204793
71Pachygyria (HP:0001302)1.95185392
72Median cleft lip (HP:0000161)1.93803554
73Abnormal ciliary motility (HP:0012262)1.93298567
74Gonadotropin excess (HP:0000837)1.92419217
75Facial cleft (HP:0002006)1.91499885
76Postaxial hand polydactyly (HP:0001162)1.90878871
77Widely spaced teeth (HP:0000687)1.90604342
78Enlarged kidneys (HP:0000105)1.88906488
79Abnormality of dental color (HP:0011073)1.87268548
80Intestinal atresia (HP:0011100)1.87158814
81Congenital hepatic fibrosis (HP:0002612)1.85124185
82Renal cortical cysts (HP:0000803)1.84707785
83Optic nerve hypoplasia (HP:0000609)1.83406540
84Midline defect of the nose (HP:0004122)1.82435594
85Prominent nasal bridge (HP:0000426)1.81918013
86Heterotopia (HP:0002282)1.81641627
87Abnormal respiratory motile cilium physiology (HP:0012261)1.81214152
88Short humerus (HP:0005792)1.81213722
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78546592
90Severe visual impairment (HP:0001141)1.77891615
91Clubbing of toes (HP:0100760)1.77457177
92Aplasia/Hypoplasia of the uvula (HP:0010293)1.77006687
93Abnormality of the renal cortex (HP:0011035)1.76889699
94Tented upper lip vermilion (HP:0010804)1.76672100
95Cupped ear (HP:0000378)1.76499507
96Volvulus (HP:0002580)1.75892860
97Abnormal platelet volume (HP:0011876)1.75765008
98Congenital primary aphakia (HP:0007707)1.75599486
99Drooling (HP:0002307)1.74692681
100Severe Myopia (HP:0011003)1.74225967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.28694492
2BCR4.63066352
3PLK43.35161983
4LATS13.23947045
5CDC42BPA3.22057580
6TGFBR23.16057398
7ACVR1B3.01122746
8NUAK12.95843660
9TAOK32.87095873
10PNCK2.46037078
11DMPK2.36656954
12BMPR1B2.30502990
13FRK2.08404828
14TRIM281.81632347
15INSRR1.74826113
16PLK21.69524412
17WNK31.64430035
18CDK31.61103000
19DYRK31.54949889
20BRD41.49003193
21SIK21.48673371
22PKN21.40404338
23FLT31.28175039
24SIK31.16878871
25MAPK131.15358249
26SGK21.13650459
27ADRBK21.10616357
28WNK11.09950016
29PTK2B1.08398699
30MKNK21.07739579
31RPS6KA41.07329143
32TGFBR11.07105006
33CASK1.07064264
34GRK11.04406524
35CAMK1G1.03624283
36HCK1.01245103
37CAMK2A1.01112662
38ROCK10.90795199
39CSNK1G10.88889025
40ZAK0.86199733
41MYLK0.84413960
42STK38L0.83042803
43AKT30.82852881
44NLK0.81193222
45MKNK10.78571601
46MAP4K20.76916453
47ADRBK10.76723221
48PRKD30.75662317
49EPHA40.75212620
50STK380.73720690
51CDK80.72616753
52CSNK1G20.72183153
53PIK3CG0.70741774
54FGFR20.69863197
55PIK3CA0.69455091
56GRK50.69069727
57STK30.68252386
58SGK4940.65832714
59SGK2230.65832714
60CSNK1G30.65672281
61TEC0.64624742
62PDK20.64597027
63PRKCE0.63792066
64PRKCG0.57814614
65MELK0.54224883
66CSNK1A1L0.50922071
67MARK10.49945285
68PRKDC0.49358270
69MATK0.48987125
70LCK0.48678895
71ATM0.47478829
72OXSR10.46228650
73PDGFRA0.45480919
74MAP3K120.44789313
75MAP3K40.44198908
76PLK10.43868962
77TNK20.42550480
78ABL10.42161946
79KIT0.41130607
80TIE10.40433444
81CAMK40.40175723
82CLK10.39199465
83PINK10.38632416
84BUB10.37762989
85PRKACB0.35051360
86ERBB30.32049862
87SGK30.29954438
88CAMK10.29722264
89CAMKK20.28680450
90BCKDK0.28127382
91PLK30.27981959
92FGR0.26601336
93PRKCB0.26245215
94FGFR10.25348241
95MAP3K70.23777611
96DYRK1A0.23766994
97VRK10.23245207
98BMX0.22445968
99STK390.22429725
100OBSCN0.21778427

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.72076694
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005634.50084907
3Regulation of autophagy_Homo sapiens_hsa041403.68855505
4Olfactory transduction_Homo sapiens_hsa047402.37728716
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.33141489
6Taste transduction_Homo sapiens_hsa047422.31095357
7Fanconi anemia pathway_Homo sapiens_hsa034602.01523579
8Non-homologous end-joining_Homo sapiens_hsa034502.00936627
9Nitrogen metabolism_Homo sapiens_hsa009102.00183027
10Fatty acid biosynthesis_Homo sapiens_hsa000611.85757966
11Propanoate metabolism_Homo sapiens_hsa006401.75436526
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.74506149
13Nicotine addiction_Homo sapiens_hsa050331.73716696
14Phototransduction_Homo sapiens_hsa047441.67919774
15Morphine addiction_Homo sapiens_hsa050321.65229703
16RNA degradation_Homo sapiens_hsa030181.64357013
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62033729
18TGF-beta signaling pathway_Homo sapiens_hsa043501.59175924
19Circadian entrainment_Homo sapiens_hsa047131.49418289
20Glutamatergic synapse_Homo sapiens_hsa047241.47982107
21N-Glycan biosynthesis_Homo sapiens_hsa005101.43871809
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43354582
23Basal transcription factors_Homo sapiens_hsa030221.35767170
24GABAergic synapse_Homo sapiens_hsa047271.33918959
25Adherens junction_Homo sapiens_hsa045201.32543669
26Calcium signaling pathway_Homo sapiens_hsa040201.19603590
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17008628
28Ether lipid metabolism_Homo sapiens_hsa005651.10971644
29Axon guidance_Homo sapiens_hsa043601.08580439
30Insulin secretion_Homo sapiens_hsa049111.07792672
31RNA transport_Homo sapiens_hsa030131.06017329
32Renin secretion_Homo sapiens_hsa049241.04262289
33Hedgehog signaling pathway_Homo sapiens_hsa043401.01200412
34Sphingolipid metabolism_Homo sapiens_hsa006001.00821661
35Butanoate metabolism_Homo sapiens_hsa006501.00585353
36Homologous recombination_Homo sapiens_hsa034400.99732527
37Steroid hormone biosynthesis_Homo sapiens_hsa001400.97898127
38ABC transporters_Homo sapiens_hsa020100.97514660
39Basal cell carcinoma_Homo sapiens_hsa052170.92817217
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91707306
41Peroxisome_Homo sapiens_hsa041460.91349034
42Serotonergic synapse_Homo sapiens_hsa047260.89737427
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89713409
44Steroid biosynthesis_Homo sapiens_hsa001000.88811981
45Linoleic acid metabolism_Homo sapiens_hsa005910.88741055
46Salivary secretion_Homo sapiens_hsa049700.87702373
47Pancreatic secretion_Homo sapiens_hsa049720.87279362
48Fatty acid degradation_Homo sapiens_hsa000710.83912871
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81566859
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80169589
51Wnt signaling pathway_Homo sapiens_hsa043100.79187272
52Dopaminergic synapse_Homo sapiens_hsa047280.78405762
53Nucleotide excision repair_Homo sapiens_hsa034200.78339059
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78150261
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78058009
56Chemical carcinogenesis_Homo sapiens_hsa052040.77281157
57Purine metabolism_Homo sapiens_hsa002300.76427248
58Tyrosine metabolism_Homo sapiens_hsa003500.75948870
59Oocyte meiosis_Homo sapiens_hsa041140.75710689
60Tight junction_Homo sapiens_hsa045300.74915180
61Hippo signaling pathway_Homo sapiens_hsa043900.73937192
62Phenylalanine metabolism_Homo sapiens_hsa003600.70293987
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70233768
64Caffeine metabolism_Homo sapiens_hsa002320.67679043
65Glycerolipid metabolism_Homo sapiens_hsa005610.67430659
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.65453093
67Platelet activation_Homo sapiens_hsa046110.64990249
68Protein export_Homo sapiens_hsa030600.61832885
69Cholinergic synapse_Homo sapiens_hsa047250.61361461
70Base excision repair_Homo sapiens_hsa034100.61294105
71Retinol metabolism_Homo sapiens_hsa008300.61113481
72Fat digestion and absorption_Homo sapiens_hsa049750.60520906
73Fatty acid metabolism_Homo sapiens_hsa012120.59778646
74Arachidonic acid metabolism_Homo sapiens_hsa005900.58259733
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58167574
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56925086
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56424508
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56028682
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55436353
80ECM-receptor interaction_Homo sapiens_hsa045120.53451385
81beta-Alanine metabolism_Homo sapiens_hsa004100.51926786
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51290025
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50975108
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50942446
85Pyrimidine metabolism_Homo sapiens_hsa002400.49608933
86cAMP signaling pathway_Homo sapiens_hsa040240.49455926
87Metabolic pathways_Homo sapiens_hsa011000.48109675
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.44618531
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44480215
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43683425
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43382867
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42447418
93Colorectal cancer_Homo sapiens_hsa052100.40903297
94Protein digestion and absorption_Homo sapiens_hsa049740.39741770
95Amphetamine addiction_Homo sapiens_hsa050310.39259779
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38888701
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38564250
98Renin-angiotensin system_Homo sapiens_hsa046140.36726439
99Selenocompound metabolism_Homo sapiens_hsa004500.35595856
100Gastric acid secretion_Homo sapiens_hsa049710.34473876

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