Rank | Gene Set | Z-score |
---|---|---|
1 | response to nerve growth factor (GO:1990089) | 6.98879887 |
2 | cellular response to nerve growth factor stimulus (GO:1990090) | 6.98879887 |
3 | establishment of nucleus localization (GO:0040023) | 6.69162857 |
4 | regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315) | 6.57191207 |
5 | cerebral cortex radially oriented cell migration (GO:0021799) | 6.48833185 |
6 | microtubule depolymerization (GO:0007019) | 5.97328465 |
7 | regulation of heat generation (GO:0031650) | 5.44401428 |
8 | intracellular lipid transport (GO:0032365) | 5.36443847 |
9 | protein targeting to Golgi (GO:0000042) | 5.18124699 |
10 | establishment of protein localization to Golgi (GO:0072600) | 5.14798324 |
11 | myelination in peripheral nervous system (GO:0022011) | 5.05486088 |
12 | peripheral nervous system axon ensheathment (GO:0032292) | 5.05486088 |
13 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 5.03179454 |
14 | negative regulation of epidermal growth factor-activated receptor activity (GO:0007175) | 4.98748525 |
15 | regulation of actin nucleation (GO:0051125) | 4.92781293 |
16 | microtubule polymerization or depolymerization (GO:0031109) | 4.52781044 |
17 | oxidative phosphorylation (GO:0006119) | 4.48347333 |
18 | protein localization to Golgi apparatus (GO:0034067) | 4.15883471 |
19 | Rac protein signal transduction (GO:0016601) | 4.09161970 |
20 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 4.06089187 |
21 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 3.99297510 |
22 | regulation of NFAT protein import into nucleus (GO:0051532) | 3.99271107 |
23 | sperm motility (GO:0030317) | 3.97155720 |
24 | cerebral cortex cell migration (GO:0021795) | 3.95762922 |
25 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.93546251 |
26 | replication fork processing (GO:0031297) | 3.93423104 |
27 | centriole replication (GO:0007099) | 3.90552789 |
28 | rRNA methylation (GO:0031167) | 3.88276797 |
29 | germ cell migration (GO:0008354) | 3.80180044 |
30 | nucleoside diphosphate catabolic process (GO:0009134) | 3.79255574 |
31 | sister chromatid cohesion (GO:0007062) | 3.78208834 |
32 | DNA-dependent DNA replication (GO:0006261) | 3.74514670 |
33 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.72359926 |
34 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.72359926 |
35 | nucleus localization (GO:0051647) | 3.66790962 |
36 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.63651042 |
37 | limb bud formation (GO:0060174) | 3.59487274 |
38 | seminiferous tubule development (GO:0072520) | 3.55964484 |
39 | protein polyglutamylation (GO:0018095) | 3.54651102 |
40 | rRNA modification (GO:0000154) | 3.46723617 |
41 | ether lipid metabolic process (GO:0046485) | 3.45338871 |
42 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.43633389 |
43 | L-ascorbic acid metabolic process (GO:0019852) | 3.26990082 |
44 | pericardium development (GO:0060039) | 3.26116199 |
45 | glycerol ether metabolic process (GO:0006662) | 3.24539193 |
46 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.22058042 |
47 | head development (GO:0060322) | 3.21481371 |
48 | tachykinin receptor signaling pathway (GO:0007217) | 3.17261969 |
49 | regulation of cilium movement (GO:0003352) | 3.15630221 |
50 | negative regulation of receptor activity (GO:2000272) | 3.13926868 |
51 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.13323995 |
52 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.13004768 |
53 | negative regulation of norepinephrine secretion (GO:0010700) | 3.11605669 |
54 | nuclear pore complex assembly (GO:0051292) | 3.11293809 |
55 | regulation of protein kinase A signaling (GO:0010738) | 3.11242380 |
56 | positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745) | 3.05684391 |
57 | positive regulation of SMAD protein import into nucleus (GO:0060391) | 3.01879044 |
58 | lateral ventricle development (GO:0021670) | 3.00758518 |
59 | negative regulation of multicellular organism growth (GO:0040015) | 3.00753124 |
60 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 2.99551132 |
61 | ether metabolic process (GO:0018904) | 2.98320456 |
62 | receptor recycling (GO:0001881) | 2.97788475 |
63 | epithelial cilium movement (GO:0003351) | 2.97465832 |
64 | polyol transport (GO:0015791) | 2.97149892 |
65 | negative regulation of calcium ion-dependent exocytosis (GO:0045955) | 2.93187783 |
66 | GPI anchor metabolic process (GO:0006505) | 2.90938123 |
67 | C-terminal protein lipidation (GO:0006501) | 2.89682314 |
68 | regulation of transcription from RNA polymerase III promoter (GO:0006359) | 2.88757061 |
69 | resolution of meiotic recombination intermediates (GO:0000712) | 2.86562992 |
70 | microtubule severing (GO:0051013) | 2.85151296 |
71 | embryonic pattern specification (GO:0009880) | 2.85134358 |
72 | fusion of sperm to egg plasma membrane (GO:0007342) | 2.84107670 |
73 | regulation of centriole replication (GO:0046599) | 2.82124647 |
74 | atrial cardiac muscle cell action potential (GO:0086014) | 2.81804298 |
75 | astrocyte development (GO:0014002) | 2.78623369 |
76 | protein targeting to vacuole (GO:0006623) | 2.78224657 |
77 | protein targeting to lysosome (GO:0006622) | 2.78224657 |
78 | establishment of protein localization to vacuole (GO:0072666) | 2.78224657 |
79 | neuronal action potential propagation (GO:0019227) | 2.76224117 |
80 | osteoblast development (GO:0002076) | 2.75287727 |
81 | centriole assembly (GO:0098534) | 2.71509099 |
82 | C-terminal protein amino acid modification (GO:0018410) | 2.70839808 |
83 | axoneme assembly (GO:0035082) | 2.70738275 |
84 | negative regulation of protein tyrosine kinase activity (GO:0061099) | 2.68933178 |
85 | regulation of ARF GTPase activity (GO:0032312) | 2.67567514 |
86 | positive regulation of heart rate (GO:0010460) | 2.66218781 |
87 | multicellular organism reproduction (GO:0032504) | 2.65501034 |
88 | positive regulation of muscle hypertrophy (GO:0014742) | 2.64810916 |
89 | positive regulation of cardiac muscle hypertrophy (GO:0010613) | 2.64810916 |
90 | regulation of uterine smooth muscle contraction (GO:0070472) | 2.62125468 |
91 | pharyngeal system development (GO:0060037) | 2.60729659 |
92 | intraciliary transport (GO:0042073) | 2.60646575 |
93 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.59611614 |
94 | regulation of mesoderm development (GO:2000380) | 2.57513321 |
95 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.56792484 |
96 | pore complex assembly (GO:0046931) | 2.56154289 |
97 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.54626621 |
98 | adaptation of signaling pathway (GO:0023058) | 2.53824885 |
99 | cilium movement (GO:0003341) | 2.53677089 |
100 | protein localization to endosome (GO:0036010) | 10.1489267 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 5.46841444 |
2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.50833077 |
3 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.33441610 |
4 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 3.29915238 |
5 | TAF15_26573619_Chip-Seq_HEK293_Human | 3.15192417 |
6 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 3.12352150 |
7 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.85529019 |
8 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.57773888 |
9 | EWS_26573619_Chip-Seq_HEK293_Human | 2.56447744 |
10 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.50596033 |
11 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.43023364 |
12 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.42352214 |
13 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.34719837 |
14 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.33222154 |
15 | FUS_26573619_Chip-Seq_HEK293_Human | 2.25121866 |
16 | P300_19829295_ChIP-Seq_ESCs_Human | 2.16744124 |
17 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.16327139 |
18 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.08571106 |
19 | VDR_22108803_ChIP-Seq_LS180_Human | 2.05579845 |
20 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.04871387 |
21 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.04604366 |
22 | ER_23166858_ChIP-Seq_MCF-7_Human | 2.01891528 |
23 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.00717541 |
24 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.96211195 |
25 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.89003171 |
26 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.80946191 |
27 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.76356993 |
28 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.75437578 |
29 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.72107436 |
30 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.69421443 |
31 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.69421443 |
32 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.69380507 |
33 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.67243105 |
34 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.65064859 |
35 | STAT3_23295773_ChIP-Seq_U87_Human | 1.64962758 |
36 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.62105990 |
37 | TP53_16413492_ChIP-PET_HCT116_Human | 1.60522795 |
38 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.60456766 |
39 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.58397087 |
40 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.54705908 |
41 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.54669061 |
42 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.50518377 |
43 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.46170377 |
44 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.45889183 |
45 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.45206952 |
46 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.45190298 |
47 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.41322728 |
48 | TCF4_23295773_ChIP-Seq_U87_Human | 1.41082420 |
49 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.37750924 |
50 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.37750924 |
51 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.36257068 |
52 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.36257068 |
53 | AR_25329375_ChIP-Seq_VCAP_Human | 1.34314514 |
54 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.32785333 |
55 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.32366057 |
56 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.32241991 |
57 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.31290513 |
58 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.29372774 |
59 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.28783536 |
60 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.27904302 |
61 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.26724367 |
62 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.22854412 |
63 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.22559796 |
64 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.21969714 |
65 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.18102565 |
66 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.17484588 |
67 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.17053804 |
68 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.15255330 |
69 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.14836750 |
70 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.14438487 |
71 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.12800089 |
72 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.12240113 |
73 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.11632560 |
74 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.11525149 |
75 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.07337721 |
76 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.07337721 |
77 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.06316812 |
78 | TBL1_22424771_ChIP-Seq_293T_Human | 1.05925249 |
79 | KDM2B_26808549_Chip-Seq_REH_Human | 1.05886609 |
80 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.05166009 |
81 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.04993034 |
82 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.03965079 |
83 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.03698168 |
84 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.02401761 |
85 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.02270811 |
86 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.01322779 |
87 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.01180171 |
88 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.00942900 |
89 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.99742906 |
90 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.99479191 |
91 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.99233331 |
92 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.98989030 |
93 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.98851026 |
94 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.97889129 |
95 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 0.97380225 |
96 | CTCF_18555785_Chip-Seq_ESCs_Mouse | 0.97223335 |
97 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.97178121 |
98 | NFYB_21822215_ChIP-Seq_K562_Human | 0.96930117 |
99 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.96871413 |
100 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.95130614 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002234_abnormal_pharynx_morphology | 3.80427747 |
2 | MP0002249_abnormal_larynx_morphology | 3.13704874 |
3 | MP0002653_abnormal_ependyma_morphology | 3.10114784 |
4 | MP0002233_abnormal_nose_morphology | 2.84218658 |
5 | MP0004043_abnormal_pH_regulation | 2.81752872 |
6 | MP0000049_abnormal_middle_ear | 2.58830740 |
7 | MP0001984_abnormal_olfaction | 2.57195711 |
8 | MP0005410_abnormal_fertilization | 2.56295292 |
9 | MP0002102_abnormal_ear_morphology | 2.20811304 |
10 | MP0001293_anophthalmia | 2.10660179 |
11 | MP0001485_abnormal_pinna_reflex | 2.07951610 |
12 | MP0004484_altered_response_of | 2.05767271 |
13 | MP0003890_abnormal_embryonic-extraembry | 2.01624520 |
14 | MP0008995_early_reproductive_senescence | 1.88405381 |
15 | MP0000778_abnormal_nervous_system | 1.87585721 |
16 | MP0005394_taste/olfaction_phenotype | 1.84899847 |
17 | MP0005499_abnormal_olfactory_system | 1.84899847 |
18 | MP0000631_abnormal_neuroendocrine_gland | 1.82784495 |
19 | MP0004859_abnormal_synaptic_plasticity | 1.78939845 |
20 | MP0001486_abnormal_startle_reflex | 1.72172982 |
21 | MP0002751_abnormal_autonomic_nervous | 1.71480842 |
22 | MP0008789_abnormal_olfactory_epithelium | 1.71195204 |
23 | MP0008004_abnormal_stomach_pH | 1.68838554 |
24 | MP0000427_abnormal_hair_cycle | 1.66054592 |
25 | MP0006054_spinal_hemorrhage | 1.63921153 |
26 | MP0001529_abnormal_vocalization | 1.62936407 |
27 | MP0003935_abnormal_craniofacial_develop | 1.62846982 |
28 | MP0000647_abnormal_sebaceous_gland | 1.61851098 |
29 | MP0003698_abnormal_male_reproductive | 1.60122218 |
30 | MP0003119_abnormal_digestive_system | 1.60100825 |
31 | MP0000613_abnormal_salivary_gland | 1.59452826 |
32 | MP0002697_abnormal_eye_size | 1.58160396 |
33 | MP0003755_abnormal_palate_morphology | 1.55924663 |
34 | MP0006292_abnormal_olfactory_placode | 1.53350402 |
35 | MP0002938_white_spotting | 1.52145745 |
36 | MP0005187_abnormal_penis_morphology | 1.51621592 |
37 | MP0001286_abnormal_eye_development | 1.47045553 |
38 | MP0009697_abnormal_copulation | 1.43149934 |
39 | MP0008260_abnormal_autophagy | 1.41968726 |
40 | MP0001929_abnormal_gametogenesis | 1.38974727 |
41 | MP0004742_abnormal_vestibular_system | 1.35170393 |
42 | MP0001299_abnormal_eye_distance/ | 1.33829314 |
43 | MP0005253_abnormal_eye_physiology | 1.32951500 |
44 | MP0005551_abnormal_eye_electrophysiolog | 1.32564192 |
45 | MP0003937_abnormal_limbs/digits/tail_de | 1.31021569 |
46 | MP0009250_abnormal_appendicular_skeleto | 1.29705676 |
47 | MP0000762_abnormal_tongue_morphology | 1.28345089 |
48 | MP0002184_abnormal_innervation | 1.24924904 |
49 | MP0002736_abnormal_nociception_after | 1.24556855 |
50 | MP0003938_abnormal_ear_development | 1.24360439 |
51 | MP0009046_muscle_twitch | 1.23242470 |
52 | MP0002109_abnormal_limb_morphology | 1.21580975 |
53 | MP0005377_hearing/vestibular/ear_phenot | 1.20074803 |
54 | MP0003878_abnormal_ear_physiology | 1.20074803 |
55 | MP0004147_increased_porphyrin_level | 1.19461296 |
56 | MP0003942_abnormal_urinary_system | 1.15249884 |
57 | MP0010030_abnormal_orbit_morphology | 1.14947202 |
58 | MP0008872_abnormal_physiological_respon | 1.13111296 |
59 | MP0008775_abnormal_heart_ventricle | 1.11494809 |
60 | MP0003385_abnormal_body_wall | 1.11052416 |
61 | MP0001986_abnormal_taste_sensitivity | 1.10065812 |
62 | MP0002116_abnormal_craniofacial_bone | 1.07446377 |
63 | MP0003122_maternal_imprinting | 1.05958104 |
64 | MP0002177_abnormal_outer_ear | 1.04243278 |
65 | MP0002282_abnormal_trachea_morphology | 1.03805646 |
66 | MP0000163_abnormal_cartilage_morphology | 1.02893049 |
67 | MP0001764_abnormal_homeostasis | 1.02811329 |
68 | MP0002272_abnormal_nervous_system | 1.02451429 |
69 | MP0003880_abnormal_central_pattern | 1.01710743 |
70 | MP0004782_abnormal_surfactant_physiolog | 1.01494882 |
71 | MP0002210_abnormal_sex_determination | 0.99725959 |
72 | MP0004133_heterotaxia | 0.98671798 |
73 | MP0000653_abnormal_sex_gland | 0.96008586 |
74 | MP0005645_abnormal_hypothalamus_physiol | 0.94977578 |
75 | MP0000534_abnormal_ureter_morphology | 0.94038800 |
76 | MP0003137_abnormal_impulse_conducting | 0.93931022 |
77 | MP0001145_abnormal_male_reproductive | 0.93804456 |
78 | MP0002734_abnormal_mechanical_nocicepti | 0.93563064 |
79 | MP0000383_abnormal_hair_follicle | 0.89397487 |
80 | MP0004085_abnormal_heartbeat | 0.89379501 |
81 | MP0006035_abnormal_mitochondrial_morpho | 0.88369745 |
82 | MP0001968_abnormal_touch/_nociception | 0.88242066 |
83 | MP0005391_vision/eye_phenotype | 0.87268819 |
84 | MP0001963_abnormal_hearing_physiology | 0.86954683 |
85 | MP0003941_abnormal_skin_development | 0.86480422 |
86 | MP0000428_abnormal_craniofacial_morphol | 0.85662556 |
87 | MP0003718_maternal_effect | 0.85128921 |
88 | MP0002152_abnormal_brain_morphology | 0.84548186 |
89 | MP0004811_abnormal_neuron_physiology | 0.83958905 |
90 | MP0002572_abnormal_emotion/affect_behav | 0.83045815 |
91 | MP0001270_distended_abdomen | 0.82919607 |
92 | MP0002127_abnormal_cardiovascular_syste | 0.82404579 |
93 | MP0003861_abnormal_nervous_system | 0.81556962 |
94 | MP0003567_abnormal_fetal_cardiomyocyte | 0.80076732 |
95 | MP0000432_abnormal_head_morphology | 0.79347908 |
96 | MP0005646_abnormal_pituitary_gland | 0.79200292 |
97 | MP0002752_abnormal_somatic_nervous | 0.76823456 |
98 | MP0009745_abnormal_behavioral_response | 0.75107365 |
99 | MP0002161_abnormal_fertility/fecundity | 0.73809628 |
100 | MP0000230_abnormal_systemic_arterial | 0.73665221 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Long nose (HP:0003189) | 5.18578925 |
2 | Conical tooth (HP:0000698) | 4.86314803 |
3 | Reduced antithrombin III activity (HP:0001976) | 4.84396711 |
4 | Broad-based gait (HP:0002136) | 4.35535078 |
5 | Progressive inability to walk (HP:0002505) | 3.75951195 |
6 | Type I transferrin isoform profile (HP:0003642) | 3.74571399 |
7 | Neoplasm of the oral cavity (HP:0100649) | 3.66446011 |
8 | Hyperventilation (HP:0002883) | 3.35280911 |
9 | Bifid tongue (HP:0010297) | 3.29628215 |
10 | Abnormality of lateral ventricle (HP:0030047) | 3.20677952 |
11 | Preaxial foot polydactyly (HP:0001841) | 3.15977986 |
12 | Pancreatic cysts (HP:0001737) | 3.14651564 |
13 | Nephronophthisis (HP:0000090) | 3.13793106 |
14 | Inability to walk (HP:0002540) | 3.11639829 |
15 | Abdominal situs inversus (HP:0003363) | 3.05453962 |
16 | Abnormality of abdominal situs (HP:0011620) | 3.05453962 |
17 | Bulbous nose (HP:0000414) | 3.04613804 |
18 | Abnormality of the labia minora (HP:0012880) | 3.00128679 |
19 | Abnormality of the intrinsic pathway (HP:0010989) | 2.85764667 |
20 | Abnormality of the pubic bones (HP:0003172) | 2.85567650 |
21 | Abnormality of the parathyroid morphology (HP:0011766) | 2.82224398 |
22 | Molar tooth sign on MRI (HP:0002419) | 2.79511408 |
23 | Abnormality of midbrain morphology (HP:0002418) | 2.79511408 |
24 | Bilateral microphthalmos (HP:0007633) | 2.73497076 |
25 | Chronic hepatic failure (HP:0100626) | 2.70817035 |
26 | Absent speech (HP:0001344) | 2.69082920 |
27 | Abnormal protein glycosylation (HP:0012346) | 2.68844704 |
28 | Abnormal glycosylation (HP:0012345) | 2.68844704 |
29 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.68844704 |
30 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.68844704 |
31 | Absent eyebrow (HP:0002223) | 2.67095734 |
32 | Pancreatic fibrosis (HP:0100732) | 2.66547385 |
33 | Hypoplastic ischia (HP:0003175) | 2.58258925 |
34 | Abnormality of macular pigmentation (HP:0008002) | 2.52648207 |
35 | Attenuation of retinal blood vessels (HP:0007843) | 2.50388940 |
36 | True hermaphroditism (HP:0010459) | 2.45188418 |
37 | Capillary hemangiomas (HP:0005306) | 2.44744676 |
38 | Tubulointerstitial nephritis (HP:0001970) | 2.44548212 |
39 | Anal stenosis (HP:0002025) | 2.43909804 |
40 | Acute lymphatic leukemia (HP:0006721) | 2.41760594 |
41 | Oligodontia (HP:0000677) | 2.40579042 |
42 | Abnormality of the ischium (HP:0003174) | 2.40032433 |
43 | Amyotrophic lateral sclerosis (HP:0007354) | 2.39330427 |
44 | Abnormality of alanine metabolism (HP:0010916) | 2.36054679 |
45 | Hyperalaninemia (HP:0003348) | 2.36054679 |
46 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.36054679 |
47 | Lissencephaly (HP:0001339) | 2.32369213 |
48 | Cystic liver disease (HP:0006706) | 2.32158987 |
49 | Abnormality of the renal medulla (HP:0100957) | 2.26333640 |
50 | Vaginal atresia (HP:0000148) | 2.22927440 |
51 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.21845274 |
52 | Anophthalmia (HP:0000528) | 2.20780149 |
53 | Genital tract atresia (HP:0001827) | 2.18878584 |
54 | Medial flaring of the eyebrow (HP:0010747) | 2.18289458 |
55 | Morphological abnormality of the middle ear (HP:0008609) | 2.16673759 |
56 | Increased mean platelet volume (HP:0011877) | 2.11010401 |
57 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 2.10120675 |
58 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.09584040 |
59 | Focal motor seizures (HP:0011153) | 2.07781050 |
60 | Absent/shortened dynein arms (HP:0200106) | 2.05853037 |
61 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.05853037 |
62 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.05586158 |
63 | Short 4th metacarpal (HP:0010044) | 2.05586158 |
64 | Exotropia (HP:0000577) | 2.03752753 |
65 | Postaxial foot polydactyly (HP:0001830) | 2.03465008 |
66 | Bell-shaped thorax (HP:0001591) | 2.00037824 |
67 | Chin dimple (HP:0010751) | 1.99700992 |
68 | Myelomeningocele (HP:0002475) | 1.97277490 |
69 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.96487062 |
70 | Abnormal lung lobation (HP:0002101) | 1.95204793 |
71 | Pachygyria (HP:0001302) | 1.95185392 |
72 | Median cleft lip (HP:0000161) | 1.93803554 |
73 | Abnormal ciliary motility (HP:0012262) | 1.93298567 |
74 | Gonadotropin excess (HP:0000837) | 1.92419217 |
75 | Facial cleft (HP:0002006) | 1.91499885 |
76 | Postaxial hand polydactyly (HP:0001162) | 1.90878871 |
77 | Widely spaced teeth (HP:0000687) | 1.90604342 |
78 | Enlarged kidneys (HP:0000105) | 1.88906488 |
79 | Abnormality of dental color (HP:0011073) | 1.87268548 |
80 | Intestinal atresia (HP:0011100) | 1.87158814 |
81 | Congenital hepatic fibrosis (HP:0002612) | 1.85124185 |
82 | Renal cortical cysts (HP:0000803) | 1.84707785 |
83 | Optic nerve hypoplasia (HP:0000609) | 1.83406540 |
84 | Midline defect of the nose (HP:0004122) | 1.82435594 |
85 | Prominent nasal bridge (HP:0000426) | 1.81918013 |
86 | Heterotopia (HP:0002282) | 1.81641627 |
87 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.81214152 |
88 | Short humerus (HP:0005792) | 1.81213722 |
89 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.78546592 |
90 | Severe visual impairment (HP:0001141) | 1.77891615 |
91 | Clubbing of toes (HP:0100760) | 1.77457177 |
92 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.77006687 |
93 | Abnormality of the renal cortex (HP:0011035) | 1.76889699 |
94 | Tented upper lip vermilion (HP:0010804) | 1.76672100 |
95 | Cupped ear (HP:0000378) | 1.76499507 |
96 | Volvulus (HP:0002580) | 1.75892860 |
97 | Abnormal platelet volume (HP:0011876) | 1.75765008 |
98 | Congenital primary aphakia (HP:0007707) | 1.75599486 |
99 | Drooling (HP:0002307) | 1.74692681 |
100 | Severe Myopia (HP:0011003) | 1.74225967 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TNIK | 5.28694492 |
2 | BCR | 4.63066352 |
3 | PLK4 | 3.35161983 |
4 | LATS1 | 3.23947045 |
5 | CDC42BPA | 3.22057580 |
6 | TGFBR2 | 3.16057398 |
7 | ACVR1B | 3.01122746 |
8 | NUAK1 | 2.95843660 |
9 | TAOK3 | 2.87095873 |
10 | PNCK | 2.46037078 |
11 | DMPK | 2.36656954 |
12 | BMPR1B | 2.30502990 |
13 | FRK | 2.08404828 |
14 | TRIM28 | 1.81632347 |
15 | INSRR | 1.74826113 |
16 | PLK2 | 1.69524412 |
17 | WNK3 | 1.64430035 |
18 | CDK3 | 1.61103000 |
19 | DYRK3 | 1.54949889 |
20 | BRD4 | 1.49003193 |
21 | SIK2 | 1.48673371 |
22 | PKN2 | 1.40404338 |
23 | FLT3 | 1.28175039 |
24 | SIK3 | 1.16878871 |
25 | MAPK13 | 1.15358249 |
26 | SGK2 | 1.13650459 |
27 | ADRBK2 | 1.10616357 |
28 | WNK1 | 1.09950016 |
29 | PTK2B | 1.08398699 |
30 | MKNK2 | 1.07739579 |
31 | RPS6KA4 | 1.07329143 |
32 | TGFBR1 | 1.07105006 |
33 | CASK | 1.07064264 |
34 | GRK1 | 1.04406524 |
35 | CAMK1G | 1.03624283 |
36 | HCK | 1.01245103 |
37 | CAMK2A | 1.01112662 |
38 | ROCK1 | 0.90795199 |
39 | CSNK1G1 | 0.88889025 |
40 | ZAK | 0.86199733 |
41 | MYLK | 0.84413960 |
42 | STK38L | 0.83042803 |
43 | AKT3 | 0.82852881 |
44 | NLK | 0.81193222 |
45 | MKNK1 | 0.78571601 |
46 | MAP4K2 | 0.76916453 |
47 | ADRBK1 | 0.76723221 |
48 | PRKD3 | 0.75662317 |
49 | EPHA4 | 0.75212620 |
50 | STK38 | 0.73720690 |
51 | CDK8 | 0.72616753 |
52 | CSNK1G2 | 0.72183153 |
53 | PIK3CG | 0.70741774 |
54 | FGFR2 | 0.69863197 |
55 | PIK3CA | 0.69455091 |
56 | GRK5 | 0.69069727 |
57 | STK3 | 0.68252386 |
58 | SGK494 | 0.65832714 |
59 | SGK223 | 0.65832714 |
60 | CSNK1G3 | 0.65672281 |
61 | TEC | 0.64624742 |
62 | PDK2 | 0.64597027 |
63 | PRKCE | 0.63792066 |
64 | PRKCG | 0.57814614 |
65 | MELK | 0.54224883 |
66 | CSNK1A1L | 0.50922071 |
67 | MARK1 | 0.49945285 |
68 | PRKDC | 0.49358270 |
69 | MATK | 0.48987125 |
70 | LCK | 0.48678895 |
71 | ATM | 0.47478829 |
72 | OXSR1 | 0.46228650 |
73 | PDGFRA | 0.45480919 |
74 | MAP3K12 | 0.44789313 |
75 | MAP3K4 | 0.44198908 |
76 | PLK1 | 0.43868962 |
77 | TNK2 | 0.42550480 |
78 | ABL1 | 0.42161946 |
79 | KIT | 0.41130607 |
80 | TIE1 | 0.40433444 |
81 | CAMK4 | 0.40175723 |
82 | CLK1 | 0.39199465 |
83 | PINK1 | 0.38632416 |
84 | BUB1 | 0.37762989 |
85 | PRKACB | 0.35051360 |
86 | ERBB3 | 0.32049862 |
87 | SGK3 | 0.29954438 |
88 | CAMK1 | 0.29722264 |
89 | CAMKK2 | 0.28680450 |
90 | BCKDK | 0.28127382 |
91 | PLK3 | 0.27981959 |
92 | FGR | 0.26601336 |
93 | PRKCB | 0.26245215 |
94 | FGFR1 | 0.25348241 |
95 | MAP3K7 | 0.23777611 |
96 | DYRK1A | 0.23766994 |
97 | VRK1 | 0.23245207 |
98 | BMX | 0.22445968 |
99 | STK39 | 0.22429725 |
100 | OBSCN | 0.21778427 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 5.72076694 |
2 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 4.50084907 |
3 | Regulation of autophagy_Homo sapiens_hsa04140 | 3.68855505 |
4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.37728716 |
5 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.33141489 |
6 | Taste transduction_Homo sapiens_hsa04742 | 2.31095357 |
7 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.01523579 |
8 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.00936627 |
9 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.00183027 |
10 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.85757966 |
11 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.75436526 |
12 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.74506149 |
13 | Nicotine addiction_Homo sapiens_hsa05033 | 1.73716696 |
14 | Phototransduction_Homo sapiens_hsa04744 | 1.67919774 |
15 | Morphine addiction_Homo sapiens_hsa05032 | 1.65229703 |
16 | RNA degradation_Homo sapiens_hsa03018 | 1.64357013 |
17 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.62033729 |
18 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.59175924 |
19 | Circadian entrainment_Homo sapiens_hsa04713 | 1.49418289 |
20 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.47982107 |
21 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.43871809 |
22 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.43354582 |
23 | Basal transcription factors_Homo sapiens_hsa03022 | 1.35767170 |
24 | GABAergic synapse_Homo sapiens_hsa04727 | 1.33918959 |
25 | Adherens junction_Homo sapiens_hsa04520 | 1.32543669 |
26 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.19603590 |
27 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.17008628 |
28 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.10971644 |
29 | Axon guidance_Homo sapiens_hsa04360 | 1.08580439 |
30 | Insulin secretion_Homo sapiens_hsa04911 | 1.07792672 |
31 | RNA transport_Homo sapiens_hsa03013 | 1.06017329 |
32 | Renin secretion_Homo sapiens_hsa04924 | 1.04262289 |
33 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.01200412 |
34 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.00821661 |
35 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.00585353 |
36 | Homologous recombination_Homo sapiens_hsa03440 | 0.99732527 |
37 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.97898127 |
38 | ABC transporters_Homo sapiens_hsa02010 | 0.97514660 |
39 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.92817217 |
40 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.91707306 |
41 | Peroxisome_Homo sapiens_hsa04146 | 0.91349034 |
42 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.89737427 |
43 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.89713409 |
44 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.88811981 |
45 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.88741055 |
46 | Salivary secretion_Homo sapiens_hsa04970 | 0.87702373 |
47 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.87279362 |
48 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.83912871 |
49 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.81566859 |
50 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.80169589 |
51 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.79187272 |
52 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.78405762 |
53 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.78339059 |
54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.78150261 |
55 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.78058009 |
56 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.77281157 |
57 | Purine metabolism_Homo sapiens_hsa00230 | 0.76427248 |
58 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.75948870 |
59 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.75710689 |
60 | Tight junction_Homo sapiens_hsa04530 | 0.74915180 |
61 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.73937192 |
62 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.70293987 |
63 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.70233768 |
64 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.67679043 |
65 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.67430659 |
66 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.65453093 |
67 | Platelet activation_Homo sapiens_hsa04611 | 0.64990249 |
68 | Protein export_Homo sapiens_hsa03060 | 0.61832885 |
69 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.61361461 |
70 | Base excision repair_Homo sapiens_hsa03410 | 0.61294105 |
71 | Retinol metabolism_Homo sapiens_hsa00830 | 0.61113481 |
72 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.60520906 |
73 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.59778646 |
74 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.58259733 |
75 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.58167574 |
76 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.56925086 |
77 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.56424508 |
78 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.56028682 |
79 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.55436353 |
80 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.53451385 |
81 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.51926786 |
82 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.51290025 |
83 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.50975108 |
84 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.50942446 |
85 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.49608933 |
86 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.49455926 |
87 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48109675 |
88 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.44618531 |
89 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.44480215 |
90 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.43683425 |
91 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.43382867 |
92 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.42447418 |
93 | Colorectal cancer_Homo sapiens_hsa05210 | 0.40903297 |
94 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.39741770 |
95 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.39259779 |
96 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.38888701 |
97 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.38564250 |
98 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.36726439 |
99 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.35595856 |
100 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.34473876 |