ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	opioid receptor signaling pathway (GO:0038003)	9.98125924
2	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	9.93956066
3	behavioral response to ethanol (GO:0048149)	8.89476406
4	regulation of translational termination (GO:0006449)	8.08181835
5	adult feeding behavior (GO:0008343)	8.04316150
6	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	7.34854939
7	negative regulation of nitric oxide biosynthetic process (GO:0045019)	6.83122783
8	regulation of acrosome reaction (GO:0060046)	6.55728633
9	positive regulation of cAMP-mediated signaling (GO:0043950)	6.52529369
10	regulation of protein glycosylation (GO:0060049)	6.36161430
11	piRNA metabolic process (GO:0034587)	6.33890721
12	thrombin receptor signaling pathway (GO:0070493)	6.27379268
13	glycerol ether metabolic process (GO:0006662)	6.01648417
14	sphingosine metabolic process (GO:0006670)	5.72761058
15	ether metabolic process (GO:0018904)	5.69807010
16	sphingoid metabolic process (GO:0046519)	5.48603231
17	diol metabolic process (GO:0034311)	5.39598433
18	negative regulation of glycoprotein biosynthetic process (GO:0010561)	5.36406494
19	cellular response to ammonium ion (GO:0071242)	5.13647455
20	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	5.02049412
21	regulation of female receptivity (GO:0045924)	4.93082202
22	pyrimidine dimer repair (GO:0006290)	4.91470875
23	mRNA cleavage (GO:0006379)	4.85392349
24	regulation of glutamate receptor signaling pathway (GO:1900449)	4.66657554
25	female mating behavior (GO:0060180)	4.38445552
26	notochord development (GO:0030903)	4.30057041
27	ncRNA catabolic process (GO:0034661)	4.29991901
28	signal complex assembly (GO:0007172)	3.99472331
29	regulation of cAMP-mediated signaling (GO:0043949)	3.95440874
30	negative regulation of glycoprotein metabolic process (GO:1903019)	3.84581962
31	negative regulation of adenylate cyclase activity (GO:0007194)	3.82517883
32	lung secretory cell differentiation (GO:0061140)	3.77060849
33	cellular response to alkaloid (GO:0071312)	3.76851081
34	cell-cell junction maintenance (GO:0045217)	3.76801096
35	negative regulation of cyclase activity (GO:0031280)	3.73022846
36	negative regulation of exocytosis (GO:0045920)	3.71160305
37	DNA replication-dependent nucleosome assembly (GO:0006335)	3.69192217
38	DNA replication-dependent nucleosome organization (GO:0034723)	3.69192217
39	fat-soluble vitamin catabolic process (GO:0042363)	3.63865007
40	vitamin catabolic process (GO:0009111)	3.63865007
41	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.60248891
42	positive regulation of icosanoid secretion (GO:0032305)	3.59892796
43	cornea development in camera-type eye (GO:0061303)	3.59733001
44	regulation of collateral sprouting (GO:0048670)	3.49425590
45	chemosensory behavior (GO:0007635)	3.46942290
46	DNA synthesis involved in DNA repair (GO:0000731)	3.46632182
47	positive regulation of fatty acid transport (GO:2000193)	3.44499214
48	proline transport (GO:0015824)	3.44442770
49	glycosphingolipid metabolic process (GO:0006687)	3.43987721
50	negative regulation of lyase activity (GO:0051350)	3.42346311
51	C4-dicarboxylate transport (GO:0015740)	3.38680755
52	preassembly of GPI anchor in ER membrane (GO:0016254)	3.33068153
53	negative regulation of cell-matrix adhesion (GO:0001953)	3.29502372
54	cilium or flagellum-dependent cell motility (GO:0001539)	3.17220599
55	left/right axis specification (GO:0070986)	3.02288774
56	regulation of odontogenesis (GO:0042481)	3.01742353
57	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.99932243
58	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.99559040
59	parturition (GO:0007567)	2.98642370
60	glomerular basement membrane development (GO:0032836)	2.97949720
61	thyroid hormone generation (GO:0006590)	2.94849270
62	regulation of memory T cell differentiation (GO:0043380)	2.90688205
63	neuronal action potential (GO:0019228)	2.88895466
64	regulation of female gonad development (GO:2000194)	2.88291112
65	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.86716957
66	glycolipid metabolic process (GO:0006664)	2.85244353
67	spermatid development (GO:0007286)	2.84293068
68	positive regulation of defense response to virus by host (GO:0002230)	2.84171875
69	omega-hydroxylase P450 pathway (GO:0097267)	2.81279734
70	dopamine receptor signaling pathway (GO:0007212)	2.80078831
71	regulation of translational elongation (GO:0006448)	2.79462971
72	regulation of icosanoid secretion (GO:0032303)	2.75991691
73	smooth muscle tissue development (GO:0048745)	2.71374004
74	liposaccharide metabolic process (GO:1903509)	2.70043744
75	cell junction maintenance (GO:0034331)	2.68076645
76	thyroid hormone metabolic process (GO:0042403)	2.62759838
77	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.62365033
78	response to morphine (GO:0043278)	2.62134103
79	positive regulation of T-helper cell differentiation (GO:0045624)	2.61268634
80	membrane lipid metabolic process (GO:0006643)	2.60393125
81	coenzyme catabolic process (GO:0009109)	2.59709331
82	epithelial cell differentiation involved in kidney development (GO:0035850)	2.59397066
83	endoderm development (GO:0007492)	2.58859775
84	histone H3-K9 modification (GO:0061647)	2.58373512
85	mast cell activation (GO:0045576)	2.56023180
86	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.54752694
87	cellular response to ATP (GO:0071318)	2.54606225
88	epoxygenase P450 pathway (GO:0019373)	2.53762457
89	regulation of calcium ion-dependent exocytosis (GO:0017158)	2.52842004
90	negative regulation of reproductive process (GO:2000242)	2.52381694
91	glomerular visceral epithelial cell development (GO:0072015)	2.52377197
92	negative regulation of cAMP biosynthetic process (GO:0030818)	2.51409306
93	positive regulation of sterol transport (GO:0032373)	2.51251785
94	positive regulation of cholesterol transport (GO:0032376)	2.51251785
95	viral mRNA export from host cell nucleus (GO:0046784)	2.50176220
96	lung epithelial cell differentiation (GO:0060487)	2.49381933
97	gene silencing by RNA (GO:0031047)	2.48551508
98	negative regulation of cytosolic calcium ion concentration (GO:0051481)	13.4483530
99	negative regulation of cAMP-mediated signaling (GO:0043951)	10.8757200
100	ether lipid metabolic process (GO:0046485)	10.0401043

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	5.29064596
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.15436637
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.41659683
4	VDR_22108803_ChIP-Seq_LS180_Human	3.45892999
5	RXR_22108803_ChIP-Seq_LS180_Human	2.63429269
6	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.51028637
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.50475054
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.47949515
9	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.44254471
10	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44254471
11	SCL_19346495_ChIP-Seq_HPC-7_Human	2.35912797
12	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	2.33978749
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.12117232
14	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.10637427
15	CBP_20019798_ChIP-Seq_JUKART_Human	2.10637427
16	EGR1_19032775_ChIP-ChIP_M12_Human	2.00823200
17	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00322660
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.94170813
19	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.92136216
20	RUNX_20019798_ChIP-Seq_JUKART_Human	1.76004245
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.73265169
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.70405806
23	NANOG_19829295_ChIP-Seq_ESCs_Human	1.69471521
24	SOX2_19829295_ChIP-Seq_ESCs_Human	1.69471521
25	HTT_18923047_ChIP-ChIP_STHdh_Human	1.68180765
26	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.67296201
27	DROSHA_22980978_ChIP-Seq_HELA_Human	1.65679842
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.57746117
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.50831278
30	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.49962010
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43087950
32	NANOG_20526341_ChIP-Seq_ESCs_Human	1.42160152
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41958346
34	STAT3_23295773_ChIP-Seq_U87_Human	1.41942230
35	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.39659014
36	TCF4_23295773_ChIP-Seq_U87_Human	1.38344493
37	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.36661539
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35358056
39	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.32756402
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29982832
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29786958
42	STAT1_20625510_ChIP-Seq_HELA_Human	1.29610030
43	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.29477495
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21605516
45	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.21038377
46	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18375885
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16140688
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.15996738
49	CDX2_22108803_ChIP-Seq_LS180_Human	1.15705349
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.15564301
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.15547876
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15357921
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15305279
54	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.15206424
55	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.14801399
56	GATA1_19941826_ChIP-Seq_K562_Human	1.14542252
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13816074
58	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.12642229
59	GATA3_27048872_Chip-Seq_THYMUS_Human	1.11452050
60	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11246444
61	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.10199484
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10178897
63	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09327305
64	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08196284
65	CEBPB_22108803_ChIP-Seq_LS180_Human	1.08041723
66	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.06325099
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.06253795
68	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.05964005
69	TP53_16413492_ChIP-PET_HCT116_Human	1.05416422
70	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.05319032
71	FUS_26573619_Chip-Seq_HEK293_Human	1.04098656
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03538485
73	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01536711
74	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01091204
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.00782234
76	AR_25329375_ChIP-Seq_VCAP_Human	0.99868836
77	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.99708459
78	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.99317547
79	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.98970340
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.97619042
81	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97122537
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.96728233
83	TCF4_22108803_ChIP-Seq_LS180_Human	0.96452730
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94797677
85	SMAD4_21799915_ChIP-Seq_A2780_Human	0.93473338
86	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.92999110
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.92836333
88	REST_21632747_ChIP-Seq_MESCs_Mouse	0.92447787
89	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92199114
90	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92146053
91	OCT4_20526341_ChIP-Seq_ESCs_Human	0.91756000
92	P300_19829295_ChIP-Seq_ESCs_Human	0.89897109
93	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.89565357
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.89545201
95	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.89456816
96	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.89175376
97	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.88816969
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.88784069
99	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.88629093
100	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.87910363

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009278_abnormal_bone_marrow	7.52376051
2	MP0009780_abnormal_chondrocyte_physiolo	4.78919695
3	MP0002876_abnormal_thyroid_physiology	4.59891629
4	MP0005360_urolithiasis	3.76595207
5	MP0005397_hematopoietic_system_phenotyp	3.72419530
6	MP0001545_abnormal_hematopoietic_system	3.72419530
7	MP0000678_abnormal_parathyroid_gland	3.24546272
8	MP0001968_abnormal_touch/_nociception	3.05753443
9	MP0000681_abnormal_thyroid_gland	2.95516294
10	MP0010234_abnormal_vibrissa_follicle	2.89349391
11	MP0005646_abnormal_pituitary_gland	2.81350207
12	MP0005503_abnormal_tendon_morphology	2.79072101
13	MP0009764_decreased_sensitivity_to	2.66738207
14	MP0003183_abnormal_peptide_metabolism	2.59774235
15	MP0003567_abnormal_fetal_cardiomyocyte	2.58150376
16	MP0001501_abnormal_sleep_pattern	2.35447817
17	MP0003045_fibrosis	2.10191628
18	MP0005551_abnormal_eye_electrophysiolog	2.06485924
19	MP0003880_abnormal_central_pattern	2.05490279
20	MP0008875_abnormal_xenobiotic_pharmacok	1.99543514
21	MP0009333_abnormal_splenocyte_physiolog	1.98419692
22	MP0001664_abnormal_digestion	1.86479571
23	MP0006035_abnormal_mitochondrial_morpho	1.81550339
24	MP0008057_abnormal_DNA_replication	1.52257556
25	MP0002249_abnormal_larynx_morphology	1.46607798
26	MP0002733_abnormal_thermal_nociception	1.44252487
27	MP0002796_impaired_skin_barrier	1.43430361
28	MP0005645_abnormal_hypothalamus_physiol	1.33434547
29	MP0003959_abnormal_lean_body	1.29414186
30	MP0009384_cardiac_valve_regurgitation	1.28690781
31	MP0003941_abnormal_skin_development	1.28261685
32	MP0005085_abnormal_gallbladder_physiolo	1.25453040
33	MP0003638_abnormal_response/metabolism_	1.23222441
34	MP0001881_abnormal_mammary_gland	1.21954095
35	MP0003950_abnormal_plasma_membrane	1.21427632
36	MP0005501_abnormal_skin_physiology	1.21416145
37	MP0003633_abnormal_nervous_system	1.20917055
38	MP0004147_increased_porphyrin_level	1.19251703
39	MP0004782_abnormal_surfactant_physiolog	1.19161007
40	MP0004264_abnormal_extraembryonic_tissu	1.16029060
41	MP0000516_abnormal_urinary_system	1.13905590
42	MP0005367_renal/urinary_system_phenotyp	1.13905590
43	MP0005310_abnormal_salivary_gland	1.12912747
44	MP0002971_abnormal_brown_adipose	1.11276560
45	MP0000230_abnormal_systemic_arterial	1.10980056
46	MP0005389_reproductive_system_phenotype	1.07709569
47	MP0002148_abnormal_hypersensitivity_rea	1.07707491
48	MP0001919_abnormal_reproductive_system	1.01368072
49	MP0003828_pulmonary_edema	1.00627003
50	MP0003191_abnormal_cellular_cholesterol	0.97635504
51	MP0000685_abnormal_immune_system	0.89532605
52	MP0002693_abnormal_pancreas_physiology	0.88159410
53	MP0000015_abnormal_ear_pigmentation	0.87564887
54	MP0002160_abnormal_reproductive_system	0.86238955
55	MP0008877_abnormal_DNA_methylation	0.83619105
56	MP0008874_decreased_physiological_sensi	0.82132643
57	MP0002396_abnormal_hematopoietic_system	0.80823449
58	MP0009745_abnormal_behavioral_response	0.79334145
59	MP0005334_abnormal_fat_pad	0.78303022
60	MP0009765_abnormal_xenobiotic_induced	0.77459072
61	MP0001835_abnormal_antigen_presentation	0.75574411
62	MP0003195_calcinosis	0.75520343
63	MP0003879_abnormal_hair_cell	0.75137373
64	MP0001486_abnormal_startle_reflex	0.75095670
65	MP0005451_abnormal_body_composition	0.73951039
66	MP0001984_abnormal_olfaction	0.72743169
67	MP0002272_abnormal_nervous_system	0.72505909
68	MP0001970_abnormal_pain_threshold	0.70562839
69	MP0003936_abnormal_reproductive_system	0.69677352
70	MP0005647_abnormal_sex_gland	0.66102112
71	MP0010771_integument_phenotype	0.65903965
72	MP0009643_abnormal_urine_homeostasis	0.62732264
73	MP0004484_altered_response_of	0.62439486
74	MP0009046_muscle_twitch	0.62128510
75	MP0002168_other_aberrant_phenotype	0.61834430
76	MP0005220_abnormal_exocrine_pancreas	0.60700288
77	MP0001986_abnormal_taste_sensitivity	0.60229312
78	MP0001270_distended_abdomen	0.60113727
79	MP0002229_neurodegeneration	0.59562541
80	MP0006276_abnormal_autonomic_nervous	0.59515033
81	MP0005195_abnormal_posterior_eye	0.57939722
82	MP0001764_abnormal_homeostasis	0.57635794
83	MP0008058_abnormal_DNA_repair	0.57533669
84	MP0000538_abnormal_urinary_bladder	0.57401744
85	MP0003631_nervous_system_phenotype	0.56850214
86	MP0002069_abnormal_eating/drinking_beha	0.55752776
87	MP0004858_abnormal_nervous_system	0.55580801
88	MP0005464_abnormal_platelet_physiology	0.54695466
89	MP0000013_abnormal_adipose_tissue	0.53682998
90	MP0000627_abnormal_mammary_gland	0.53243199
91	MP0004859_abnormal_synaptic_plasticity	0.51575241
92	MP0003953_abnormal_hormone_level	0.51533767
93	MP0010155_abnormal_intestine_physiology	0.50615161
94	MP0001661_extended_life_span	0.50039251
95	MP0008872_abnormal_physiological_respon	0.49207074
96	MP0003646_muscle_fatigue	0.49199500
97	MP0004085_abnormal_heartbeat	0.49149836
98	MP0005670_abnormal_white_adipose	0.47939604
99	MP0001765_abnormal_ion_homeostasis	0.47185649
100	MP0003698_abnormal_male_reproductive	0.47076103

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Volvulus (HP:0002580)	6.34519484
2	Broad alveolar ridges (HP:0000187)	6.07295433
3	Abnormality of the aortic arch (HP:0012303)	5.78451262
4	Intestinal atresia (HP:0011100)	5.54785996
5	Mesangial abnormality (HP:0001966)	5.26132795
6	Pancreatic islet-cell hyperplasia (HP:0004510)	5.11538187
7	Poor head control (HP:0002421)	4.99115405
8	Testicular neoplasm (HP:0010788)	4.58667740
9	Thickened helices (HP:0000391)	4.35688872
10	Large for gestational age (HP:0001520)	4.19909157
11	Elevated erythrocyte sedimentation rate (HP:0003565)	4.18500482
12	Myositis (HP:0100614)	4.13650933
13	Cutaneous melanoma (HP:0012056)	4.08034890
14	Oligodontia (HP:0000677)	3.92260860
15	Gaze-evoked nystagmus (HP:0000640)	3.81575984
16	Abnormality of the pancreatic islet cells (HP:0006476)	3.54468827
17	Abnormality of endocrine pancreas physiology (HP:0012093)	3.54468827
18	Congenital ichthyosiform erythroderma (HP:0007431)	3.48648382
19	Agitation (HP:0000713)	3.44976953
20	Cone-rod dystrophy (HP:0000548)	3.29693685
21	Nephroblastoma (Wilms tumor) (HP:0002667)	3.24987124
22	Hyperthyroidism (HP:0000836)	3.19099360
23	Abnormality of the ileum (HP:0001549)	3.10494467
24	Abnormality of macular pigmentation (HP:0008002)	3.08893138
25	Embryonal renal neoplasm (HP:0011794)	3.01777477
26	Tented upper lip vermilion (HP:0010804)	3.00708267
27	Focal motor seizures (HP:0011153)	3.00552333
28	Large eyes (HP:0001090)	2.96456055
29	Tubular atrophy (HP:0000092)	2.88209435
30	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.82361564
31	Gonadal dysgenesis (HP:0000133)	2.82315286
32	Increased corneal curvature (HP:0100692)	2.74236426
33	Keratoconus (HP:0000563)	2.74236426
34	Abnormality of the alveolar ridges (HP:0006477)	2.74054182
35	Hyperpituitarism (HP:0010514)	2.71565696
36	Dysdiadochokinesis (HP:0002075)	2.67165874
37	Central scotoma (HP:0000603)	2.59011120
38	Nonprogressive disorder (HP:0003680)	2.57274073
39	Poikiloderma (HP:0001029)	2.51252323
40	Optic nerve hypoplasia (HP:0000609)	2.47889906
41	Chromsome breakage (HP:0040012)	2.43274140
42	Cerebellar dysplasia (HP:0007033)	2.43072816
43	Neoplasm of the lung (HP:0100526)	2.41353867
44	Hypoproteinemia (HP:0003075)	2.38736169
45	Gastrointestinal atresia (HP:0002589)	2.36988639
46	Entropion (HP:0000621)	2.35072561
47	Poor speech (HP:0002465)	2.33281487
48	Facial diplegia (HP:0001349)	2.33219098
49	Orchitis (HP:0100796)	2.31730932
50	Pigmentary retinal degeneration (HP:0001146)	2.31119376
51	Type II lissencephaly (HP:0007260)	2.30131249
52	Ectropion (HP:0000656)	2.28522535
53	Goiter (HP:0000853)	2.21231326
54	Neoplasm of the respiratory system (HP:0100606)	2.20197446
55	Pili torti (HP:0003777)	2.18576645
56	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.16700543
57	Progressive inability to walk (HP:0002505)	2.15861826
58	High anterior hairline (HP:0009890)	2.14520276
59	Hamartoma (HP:0010566)	2.11612499
60	Decreased circulating renin level (HP:0003351)	2.05901779
61	Long nose (HP:0003189)	2.03646813
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.03381123
63	Dialeptic seizures (HP:0011146)	2.00898826
64	Thyroid-stimulating hormone excess (HP:0002925)	11.9788321
65	Abnormality of liposaccharide metabolism (HP:0010968)	1.99147256
66	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.99147256
67	Abnormality of glycolipid metabolism (HP:0010969)	1.99147256
68	Meningioma (HP:0002858)	1.97730125
69	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96625391
70	Autoimmune hemolytic anemia (HP:0001890)	1.96338789
71	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.91563731
72	Decreased central vision (HP:0007663)	1.90672443
73	3-Methylglutaconic aciduria (HP:0003535)	1.90563643
74	Neonatal respiratory distress (HP:0002643)	1.89744633
75	Asplenia (HP:0001746)	1.89540939
76	Abolished electroretinogram (ERG) (HP:0000550)	1.89323751
77	Focal seizures (HP:0007359)	1.87741738
78	Neoplasm of the adrenal cortex (HP:0100641)	1.87172281
79	Squamous cell carcinoma (HP:0002860)	1.83344852
80	Atonic seizures (HP:0010819)	1.82597332
81	Striae distensae (HP:0001065)	1.81520123
82	Broad-based gait (HP:0002136)	1.81454870
83	Mediastinal lymphadenopathy (HP:0100721)	1.81223501
84	Embryonal neoplasm (HP:0002898)	1.80601671
85	Abnormal hair laboratory examination (HP:0003328)	1.79842326
86	Diastasis recti (HP:0001540)	1.78679440
87	Scotoma (HP:0000575)	1.74943519
88	Hyperventilation (HP:0002883)	1.74061905
89	Severe visual impairment (HP:0001141)	1.73341175
90	Episodic fever (HP:0001954)	1.71036633
91	Macroorchidism (HP:0000053)	1.69906315
92	Abnormality of the vitreous humor (HP:0004327)	1.69041771
93	Microvesicular hepatic steatosis (HP:0001414)	1.67162136
94	Amblyopia (HP:0000646)	1.66616912
95	Hypercortisolism (HP:0001578)	1.65995504
96	Adrenal overactivity (HP:0002717)	1.65105622
97	Metabolic alkalosis (HP:0200114)	1.64816483
98	Hyperaldosteronism (HP:0000859)	1.64215740
99	Male pseudohermaphroditism (HP:0000037)	1.63258687
100	Abnormality of the renal cortex (HP:0011035)	1.61237012

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	8.86739123
2	FRK	6.72999460
3	ERN1	4.29411345
4	PINK1	3.45205962
5	DYRK3	3.02096721
6	ZAK	2.83111115
7	TAOK3	2.59606228
8	IRAK3	2.55162495
9	ADRBK1	2.29263445
10	MAP3K6	2.08791075
11	ACVR1B	1.66499143
12	FGFR2	1.66492823
13	RIPK1	1.53906744
14	KIT	1.36757808
15	IRAK1	1.29246917
16	TGFBR1	1.28533087
17	MAPKAPK3	1.27567475
18	PRKCE	1.27138662
19	MAP3K10	1.23986908
20	PRKCG	1.17091657
21	PNCK	1.16753009
22	TNK2	1.06247759
23	FLT3	1.05973295
24	BCKDK	1.04322810
25	MAP4K1	1.01826308
26	MAPK11	0.99274920
27	NLK	0.97926587
28	CLK1	0.97429339
29	TYRO3	0.95400855
30	JAK3	0.92865226
31	TXK	0.92090693
32	CSF1R	0.90787271
33	MKNK1	0.90569271
34	MAP3K4	0.90270283
35	ITK	0.83593241
36	PLK2	0.81710643
37	MAP2K4	0.80468259
38	PRKCI	0.77775786
39	BMPR1B	0.70732096
40	WNK3	0.69011514
41	CCNB1	0.67813308
42	KDR	0.67797913
43	TNIK	0.66153114
44	MKNK2	0.59683918
45	GRK1	0.58940637
46	PKN2	0.56775078
47	CAMK2A	0.54967014
48	SYK	0.54592646
49	FGFR3	0.51775710
50	DYRK1A	0.50641775
51	BTK	0.50178153
52	CSNK1A1L	0.49237136
53	TEC	0.47116160
54	CSNK1G3	0.44108508
55	SGK1	0.43770080
56	TBK1	0.43339823
57	MAP2K2	0.42953738
58	MAP2K6	0.42949164
59	CAMK1G	0.41103755
60	CSNK1G1	0.40750086
61	RET	0.39508821
62	MATK	0.38701400
63	LCK	0.37802571
64	MAPK15	0.36379019
65	MAPK3	0.35054048
66	PRKCB	0.34404114
67	IKBKB	0.34105682
68	GRK7	0.33562559
69	MAP2K3	0.33407563
70	NUAK1	0.31979426
71	GRK5	0.31957219
72	PIK3CG	0.31867077
73	GRK6	0.31486281
74	HIPK2	0.31174179
75	MAPK1	0.30580816
76	STK38L	0.29169374
77	MAPK7	0.28989299
78	PRKCA	0.28839376
79	RPS6KA3	0.27695136
80	NEK9	0.27320092
81	PIM1	0.27223992
82	CAMK1	0.26454627
83	ABL1	0.25744020
84	PLK4	0.25140550
85	PRKCZ	0.24417839
86	ZAP70	0.23141678
87	CSNK2A2	0.22528326
88	MAP3K5	0.21911347
89	OXSR1	0.21500837
90	ATR	0.20795270
91	RPS6KA6	0.20493571
92	GSK3B	0.20177870
93	MAP3K11	0.20045378
94	MAPKAPK5	0.18732050
95	LYN	0.17782118
96	MAPK13	0.17577375
97	CSNK1A1	0.17324209
98	ATM	0.16654360
99	PRKACG	0.16396039
100	RIPK4	0.16349066

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Dorso-ventral axis formation_Homo sapiens_hsa04320	4.11018015
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.89347313
3	Olfactory transduction_Homo sapiens_hsa04740	2.85910679
4	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.69286768
5	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.64841080
6	ABC transporters_Homo sapiens_hsa02010	2.59145321
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.48689195
8	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.46637712
9	Sphingolipid metabolism_Homo sapiens_hsa00600	2.36148674
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.35436828
11	Taste transduction_Homo sapiens_hsa04742	2.21860768
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.20761107
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.10785975
14	Phototransduction_Homo sapiens_hsa04744	2.10581258
15	Selenocompound metabolism_Homo sapiens_hsa00450	2.00533934
16	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.92748133
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90691135
18	Morphine addiction_Homo sapiens_hsa05032	1.84373516
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.74376182
20	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.69742716
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.69205926
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.64414368
23	Pentose phosphate pathway_Homo sapiens_hsa00030	1.60315139
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.54530172
25	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.41339507
26	Glycerolipid metabolism_Homo sapiens_hsa00561	1.34387769
27	Butanoate metabolism_Homo sapiens_hsa00650	1.31121739
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.28331016
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26316456
30	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.25459450
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24667536
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19901815
33	Retinol metabolism_Homo sapiens_hsa00830	1.17223379
34	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.17187841
35	Asthma_Homo sapiens_hsa05310	1.10719758
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.07457648
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04002592
38	Graft-versus-host disease_Homo sapiens_hsa05332	0.97510530
39	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.97276797
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94301292
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.93687498
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93208549
43	Primary immunodeficiency_Homo sapiens_hsa05340	0.91345953
44	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.91118285
45	Homologous recombination_Homo sapiens_hsa03440	0.90867295
46	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.89966347
47	Salivary secretion_Homo sapiens_hsa04970	0.89616705
48	Fatty acid degradation_Homo sapiens_hsa00071	0.87456434
49	Histidine metabolism_Homo sapiens_hsa00340	0.85100714
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84642776
51	Caffeine metabolism_Homo sapiens_hsa00232	0.83044923
52	Complement and coagulation cascades_Homo sapiens_hsa04610	0.82821101
53	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.82498625
54	Base excision repair_Homo sapiens_hsa03410	0.81026257
55	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.79345872
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.74771760
57	Pancreatic secretion_Homo sapiens_hsa04972	0.74670807
58	Estrogen signaling pathway_Homo sapiens_hsa04915	0.73300846
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.73272927
60	Allograft rejection_Homo sapiens_hsa05330	0.72902036
61	Sulfur relay system_Homo sapiens_hsa04122	0.72831117
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.71779976
63	Notch signaling pathway_Homo sapiens_hsa04330	0.69931009
64	Peroxisome_Homo sapiens_hsa04146	0.65970237
65	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.65820401
66	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.65339723
67	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.63079267
68	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.60705422
69	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.58281477
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.57061686
71	Lysosome_Homo sapiens_hsa04142	0.56578912
72	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.54695191
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53916592
74	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52143204
75	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.50762214
76	Mineral absorption_Homo sapiens_hsa04978	0.50575566
77	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47176742
78	Purine metabolism_Homo sapiens_hsa00230	0.45739646
79	Long-term depression_Homo sapiens_hsa04730	0.45146635
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44946105
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.43581504
82	Platelet activation_Homo sapiens_hsa04611	0.43480604
83	African trypanosomiasis_Homo sapiens_hsa05143	0.42221113
84	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.41335292
85	Circadian entrainment_Homo sapiens_hsa04713	0.41034450
86	Glutathione metabolism_Homo sapiens_hsa00480	0.39641075
87	Renin secretion_Homo sapiens_hsa04924	0.39474157
88	Bile secretion_Homo sapiens_hsa04976	0.38988099
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38668665
90	Metabolic pathways_Homo sapiens_hsa01100	0.37972883
91	Insulin secretion_Homo sapiens_hsa04911	0.37467951
92	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35859857
93	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.34991546
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34446199
95	Serotonergic synapse_Homo sapiens_hsa04726	0.34195020
96	Regulation of autophagy_Homo sapiens_hsa04140	0.31248976
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.30388185
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.27023764
99	Antigen processing and presentation_Homo sapiens_hsa04612	0.26149549
100	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.25437108

ENPP7P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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