ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	8.00264124
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.65177329
3	sulfate transmembrane transport (GO:1902358)	6.96857718
4	cilium movement (GO:0003341)	6.51285298
5	amine catabolic process (GO:0009310)	6.41325464
6	cellular biogenic amine catabolic process (GO:0042402)	6.41325464
7	axoneme assembly (GO:0035082)	6.33992651
8	cilium or flagellum-dependent cell motility (GO:0001539)	6.25464327
9	kynurenine metabolic process (GO:0070189)	6.17032898
10	tryptophan catabolic process (GO:0006569)	6.10945781
11	indole-containing compound catabolic process (GO:0042436)	6.10945781
12	indolalkylamine catabolic process (GO:0046218)	6.10945781
13	retinal rod cell development (GO:0046548)	5.90943799
14	sulfate transport (GO:0008272)	5.87736564
15	epithelial cilium movement (GO:0003351)	5.84840560
16	retinal cone cell development (GO:0046549)	5.55613977
17	brain morphogenesis (GO:0048854)	5.21805969
18	axonemal dynein complex assembly (GO:0070286)	5.11998759
19	motile cilium assembly (GO:0044458)	5.11473935
20	activated T cell proliferation (GO:0050798)	4.89794731
21	tryptophan metabolic process (GO:0006568)	4.46031073
22	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	4.38161643
23	arginine metabolic process (GO:0006525)	4.28664895
24	regulation of phospholipase A2 activity (GO:0032429)	4.12737969
25	urea cycle (GO:0000050)	4.03573196
26	ventricular system development (GO:0021591)	3.96467905
27	aromatic amino acid family catabolic process (GO:0009074)	3.87090016
28	pyrimidine nucleobase catabolic process (GO:0006208)	3.81759336
29	nitrogen cycle metabolic process (GO:0071941)	3.67598167
30	indolalkylamine metabolic process (GO:0006586)	3.67575393
31	neuron fate determination (GO:0048664)	3.65828527
32	multicellular organism reproduction (GO:0032504)	3.65106402
33	protein neddylation (GO:0045116)	3.58359816
34	urea metabolic process (GO:0019627)	3.57178241
35	regulation of cilium movement (GO:0003352)	3.52797838
36	platelet dense granule organization (GO:0060155)	3.50699812
37	benzene-containing compound metabolic process (GO:0042537)	3.33970591
38	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.32443167
39	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.30652068
40	snRNA transcription (GO:0009301)	3.30610907
41	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.28483351
42	radial glial cell differentiation (GO:0060019)	3.24491657
43	cerebral cortex radially oriented cell migration (GO:0021799)	3.22087155
44	microtubule bundle formation (GO:0001578)	3.21330616
45	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.17568713
46	nucleobase catabolic process (GO:0046113)	3.07409892
47	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.06373321
48	protein targeting to Golgi (GO:0000042)	3.03740157
49	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.03433918
50	acrosome assembly (GO:0001675)	3.02927462
51	endosome to pigment granule transport (GO:0043485)	2.96793878
52	endosome to melanosome transport (GO:0035646)	2.96793878
53	establishment of protein localization to Golgi (GO:0072600)	2.96280482
54	cilium morphogenesis (GO:0060271)	2.95896305
55	negative regulation of heart rate (GO:0010459)	2.94299797
56	negative regulation of protein localization to cell surface (GO:2000009)	2.80731207
57	glyoxylate metabolic process (GO:0046487)	2.80510212
58	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.79181397
59	polyol catabolic process (GO:0046174)	2.75251444
60	negative regulation of platelet activation (GO:0010544)	2.75011687
61	response to methylmercury (GO:0051597)	2.73394449
62	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.71243842
63	response to acidic pH (GO:0010447)	2.70117021
64	regulation of acrosome reaction (GO:0060046)	2.68328283
65	regulation of phospholipid biosynthetic process (GO:0071071)	2.68117043
66	positive regulation of neurotransmitter secretion (GO:0001956)	2.67993358
67	cilium organization (GO:0044782)	2.67590307
68	positive regulation of cAMP-mediated signaling (GO:0043950)	2.66954788
69	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.66899761
70	sulfation (GO:0051923)	2.65893565
71	growth hormone receptor signaling pathway (GO:0060396)	2.65038995
72	aromatic amino acid family metabolic process (GO:0009072)	2.64040079
73	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.63527157
74	phospholipid homeostasis (GO:0055091)	2.63159231
75	sperm motility (GO:0030317)	2.59690936
76	regulation of integrin activation (GO:0033623)	2.59424970
77	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.58044232
78	regulation of integrin-mediated signaling pathway (GO:2001044)	2.57845009
79	neuron recognition (GO:0008038)	2.56257431
80	positive regulation of endothelial cell differentiation (GO:0045603)	2.55685719
81	positive regulation of protein homodimerization activity (GO:0090073)	2.54764186
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.54222087
83	central nervous system myelination (GO:0022010)	2.53441961
84	axon ensheathment in central nervous system (GO:0032291)	2.53441961
85	fatty acid transmembrane transport (GO:1902001)	2.53102969
86	cGMP-mediated signaling (GO:0019934)	2.52801346
87	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.51426596
88	presynaptic membrane assembly (GO:0097105)	2.49126130
89	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.48415365
90	negative regulation of appetite (GO:0032099)	2.47187529
91	negative regulation of response to food (GO:0032096)	2.47187529
92	xenobiotic catabolic process (GO:0042178)	2.47071265
93	adenosine receptor signaling pathway (GO:0001973)	2.46020180
94	melanosome organization (GO:0032438)	2.45378312
95	kidney morphogenesis (GO:0060993)	2.44468035
96	tyrosine metabolic process (GO:0006570)	2.42048190
97	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.41143091
98	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.41011242
99	cardiovascular system development (GO:0072358)	2.40599176
100	cellular component assembly involved in morphogenesis (GO:0010927)	2.39868631

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.49963832
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.14013791
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.76600855
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.16113355
5	AR_21572438_ChIP-Seq_LNCaP_Human	2.50743321
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.38715518
7	VDR_22108803_ChIP-Seq_LS180_Human	2.35107679
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21937544
9	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.20567740
10	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.14487119
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.12461264
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.00572650
13	SMAD4_21799915_ChIP-Seq_A2780_Human	1.95192386
14	P300_19829295_ChIP-Seq_ESCs_Human	1.88317003
15	DROSHA_22980978_ChIP-Seq_HELA_Human	1.86305141
16	TP53_16413492_ChIP-PET_HCT116_Human	1.84127519
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.83148036
18	STAT3_23295773_ChIP-Seq_U87_Human	1.81678988
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81455132
20	ZNF274_21170338_ChIP-Seq_K562_Hela	1.76806145
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76703441
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.75846794
23	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.74185160
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73153124
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.71210854
26	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.69490530
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66539304
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66530476
29	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.62012184
30	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.58680190
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.55400946
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50389795
33	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.48235497
34	TCF4_23295773_ChIP-Seq_U87_Human	1.45319479
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.44601643
36	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.43555846
37	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.42639560
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38199549
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37880478
40	AR_25329375_ChIP-Seq_VCAP_Human	1.37297912
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36762173
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.35482388
43	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35379557
44	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.33580888
45	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.32776467
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32093298
47	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.31202611
48	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.29108481
49	EWS_26573619_Chip-Seq_HEK293_Human	1.27752013
50	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.24942558
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24819264
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24819264
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23000278
54	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22946607
55	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.22478605
56	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.22360102
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22264238
58	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.21832269
59	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.20199678
60	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19822286
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19241074
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19241074
63	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.16076483
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.15500606
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10263744
66	TBL1_22424771_ChIP-Seq_293T_Human	1.09102667
67	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06693076
68	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.06414938
69	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.04774028
70	ER_23166858_ChIP-Seq_MCF-7_Human	1.04587810
71	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.04571924
72	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.02630637
73	KDM2B_26808549_Chip-Seq_REH_Human	0.98975090
74	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98401178
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97652169
76	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97543304
77	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.97439142
78	FUS_26573619_Chip-Seq_HEK293_Human	0.97229853
79	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.97155256
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96810987
81	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.96479273
82	TP53_18474530_ChIP-ChIP_U2OS_Human	0.95986629
83	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95485029
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94806531
85	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.92832106
86	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.92832106
87	RNF2_27304074_Chip-Seq_NSC_Mouse	0.91179408
88	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.90541322
89	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.90201002
90	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.89559829
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.88464303
92	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88464303
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88400273
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87743678
95	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.87335480
96	VDR_24787735_ChIP-Seq_THP-1_Human	0.86626392
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86386585
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.84952682
99	NFYA_21822215_ChIP-Seq_K562_Human	0.84930891
100	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.84398170

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	5.15073663
2	MP0003136_yellow_coat_color	3.95726807
3	MP0002837_dystrophic_cardiac_calcinosis	3.61076945
4	MP0000569_abnormal_digit_pigmentation	3.57984019
5	MP0005464_abnormal_platelet_physiology	3.17284407
6	MP0005174_abnormal_tail_pigmentation	3.03738274
7	MP0008004_abnormal_stomach_pH	2.91662974
8	MP0000015_abnormal_ear_pigmentation	2.69406972
9	MP0002090_abnormal_vision	2.68705574
10	MP0005551_abnormal_eye_electrophysiolog	2.59907970
11	MP0002102_abnormal_ear_morphology	2.41006588
12	MP0001984_abnormal_olfaction	2.23541516
13	MP0000372_irregular_coat_pigmentation	2.19096204
14	MP0005171_absent_coat_pigmentation	1.94593353
15	MP0005253_abnormal_eye_physiology	1.90418188
16	MP0004859_abnormal_synaptic_plasticity	1.87193737
17	MP0006292_abnormal_olfactory_placode	1.87171147
18	MP0008872_abnormal_physiological_respon	1.81205844
19	MP0005248_abnormal_Harderian_gland	1.80127009
20	MP0005646_abnormal_pituitary_gland	1.80024584
21	MP0005394_taste/olfaction_phenotype	1.75345604
22	MP0005499_abnormal_olfactory_system	1.75345604
23	MP0004134_abnormal_chest_morphology	1.73722378
24	MP0005084_abnormal_gallbladder_morpholo	1.61531405
25	MP0002736_abnormal_nociception_after	1.61482624
26	MP0009046_muscle_twitch	1.50879481
27	MP0003183_abnormal_peptide_metabolism	1.49040352
28	MP0002638_abnormal_pupillary_reflex	1.38925372
29	MP0004381_abnormal_hair_follicle	1.37895282
30	MP0008789_abnormal_olfactory_epithelium	1.35887057
31	MP0003878_abnormal_ear_physiology	1.35227188
32	MP0005377_hearing/vestibular/ear_phenot	1.35227188
33	MP0005410_abnormal_fertilization	1.34207848
34	MP0008775_abnormal_heart_ventricle	1.33940729
35	MP0005387_immune_system_phenotype	1.33473740
36	MP0001790_abnormal_immune_system	1.33473740
37	MP0002163_abnormal_gland_morphology	1.32054458
38	MP0002132_abnormal_respiratory_system	1.31195857
39	MP0004233_abnormal_muscle_weight	1.30838121
40	MP0002735_abnormal_chemical_nociception	1.30510142
41	MP0004084_abnormal_cardiac_muscle	1.28907620
42	MP0005195_abnormal_posterior_eye	1.27420217
43	MP0005083_abnormal_biliary_tract	1.26970679
44	MP0006276_abnormal_autonomic_nervous	1.26680895
45	MP0005408_hypopigmentation	1.23027281
46	MP0000230_abnormal_systemic_arterial	1.21879381
47	MP0003122_maternal_imprinting	1.20964920
48	MP0002557_abnormal_social/conspecific_i	1.19591510
49	MP0002160_abnormal_reproductive_system	1.18437864
50	MP0002229_neurodegeneration	1.17331968
51	MP0002095_abnormal_skin_pigmentation	1.14934911
52	MP0005623_abnormal_meninges_morphology	1.12517725
53	MP0009780_abnormal_chondrocyte_physiolo	1.12377033
54	MP0005167_abnormal_blood-brain_barrier	1.08890929
55	MP0005409_darkened_coat_color	1.06148587
56	MP0000778_abnormal_nervous_system	1.04756461
57	MP0001486_abnormal_startle_reflex	1.04741058
58	MP0001324_abnormal_eye_pigmentation	1.03772572
59	MP0004142_abnormal_muscle_tone	0.99765346
60	MP0001970_abnormal_pain_threshold	0.98163986
61	MP0006054_spinal_hemorrhage	0.97055342
62	MP0001485_abnormal_pinna_reflex	0.96065702
63	MP0001968_abnormal_touch/_nociception	0.95797645
64	MP0001502_abnormal_circadian_rhythm	0.95769113
65	MP0003635_abnormal_synaptic_transmissio	0.94563349
66	MP0001849_ear_inflammation	0.93377909
67	MP0005503_abnormal_tendon_morphology	0.93157219
68	MP0005391_vision/eye_phenotype	0.91666173
69	MP0004043_abnormal_pH_regulation	0.90415007
70	MP0008058_abnormal_DNA_repair	0.88913478
71	MP0002572_abnormal_emotion/affect_behav	0.87687793
72	MP0003959_abnormal_lean_body	0.86746284
73	MP0003879_abnormal_hair_cell	0.86603329
74	MP0003880_abnormal_central_pattern	0.85973621
75	MP0006035_abnormal_mitochondrial_morpho	0.85831571
76	MP0002272_abnormal_nervous_system	0.85533479
77	MP0003045_fibrosis	0.84847563
78	MP0005448_abnormal_energy_balance	0.84058551
79	MP0009745_abnormal_behavioral_response	0.83705736
80	MP0005075_abnormal_melanosome_morpholog	0.82355473
81	MP0002733_abnormal_thermal_nociception	0.82089733
82	MP0003195_calcinosis	0.81332486
83	MP0000427_abnormal_hair_cycle	0.78894038
84	MP0001919_abnormal_reproductive_system	0.78127019
85	MP0001963_abnormal_hearing_physiology	0.77721628
86	MP0001501_abnormal_sleep_pattern	0.77659952
87	MP0005058_abnormal_lysosome_morphology	0.77510132
88	MP0004147_increased_porphyrin_level	0.77195497
89	MP0003698_abnormal_male_reproductive	0.77172220
90	MP0005165_increased_susceptibility_to	0.77072241
91	MP0005620_abnormal_muscle_contractility	0.76226059
92	MP0004130_abnormal_muscle_cell	0.76165261
93	MP0005193_abnormal_anterior_eye	0.75072051
94	MP0001293_anophthalmia	0.72995469
95	MP0008877_abnormal_DNA_methylation	0.72791371
96	MP0002752_abnormal_somatic_nervous	0.69837061
97	MP0002067_abnormal_sensory_capabilities	0.69706410
98	MP0004924_abnormal_behavior	0.69325647
99	MP0005386_behavior/neurological_phenoty	0.69325647
100	MP0002938_white_spotting	0.69191552

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.62593502
2	Absent/shortened dynein arms (HP:0200106)	7.62593502
3	Abnormal ciliary motility (HP:0012262)	6.49976841
4	Entropion (HP:0000621)	6.20202132
5	Poikiloderma (HP:0001029)	5.81814155
6	Abnormal respiratory epithelium morphology (HP:0012253)	5.27002374
7	Abnormal respiratory motile cilium morphology (HP:0005938)	5.27002374
8	Abnormal respiratory motile cilium physiology (HP:0012261)	5.21945191
9	Abnormality of DNA repair (HP:0003254)	4.90309381
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.89388825
11	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.81766766
12	Rhinitis (HP:0012384)	3.98691748
13	Prolonged bleeding time (HP:0003010)	3.89964012
14	Increased mean platelet volume (HP:0011877)	3.68619545
15	Cerebellar dysplasia (HP:0007033)	3.54275749
16	Type II lissencephaly (HP:0007260)	3.41678500
17	Abnormal platelet volume (HP:0011876)	3.31171193
18	Abnormal rod and cone electroretinograms (HP:0008323)	3.24327222
19	Menorrhagia (HP:0000132)	3.17805734
20	Ectropion (HP:0000656)	3.15628257
21	Lissencephaly (HP:0001339)	3.15403429
22	Petechiae (HP:0000967)	3.12570004
23	Hyperlipoproteinemia (HP:0010980)	2.90057602
24	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.69522084
25	Bronchiectasis (HP:0002110)	2.66871228
26	Fair hair (HP:0002286)	2.65780850
27	Dyschromatopsia (HP:0007641)	2.62161303
28	Chronic bronchitis (HP:0004469)	2.62155398
29	Purpura (HP:0000979)	2.60277363
30	Papilledema (HP:0001085)	2.59023641
31	Severe visual impairment (HP:0001141)	2.57018521
32	Confusion (HP:0001289)	2.55833520
33	Impaired social interactions (HP:0000735)	2.55233989
34	Abnormal social behavior (HP:0012433)	2.55233989
35	Breast hypoplasia (HP:0003187)	2.51565107
36	3-Methylglutaconic aciduria (HP:0003535)	2.48410569
37	Hip dysplasia (HP:0001385)	2.47474775
38	Focal motor seizures (HP:0011153)	2.45814137
39	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.44818455
40	Nasal polyposis (HP:0100582)	2.41173489
41	White forelock (HP:0002211)	2.37692847
42	Pancreatic islet-cell hyperplasia (HP:0004510)	2.35271389
43	Wide intermamillary distance (HP:0006610)	2.33896184
44	Chronic hepatic failure (HP:0100626)	2.29832647
45	Respiratory distress (HP:0002098)	2.28584782
46	Generalized hypopigmentation (HP:0007513)	2.24433018
47	Keratitis (HP:0000491)	2.23235305
48	Abnormal hair whorl (HP:0010721)	2.20808877
49	Palpebral edema (HP:0100540)	2.19203679
50	Severe muscular hypotonia (HP:0006829)	2.17417577
51	Bony spicule pigmentary retinopathy (HP:0007737)	2.17202584
52	Hypoplastic labia majora (HP:0000059)	2.17020658
53	Visual hallucinations (HP:0002367)	2.15421912
54	Poor eye contact (HP:0000817)	2.14542177
55	Increased cerebral lipofuscin (HP:0011813)	2.12116959
56	Generalized hypopigmentation of hair (HP:0011358)	2.11706859
57	Renal dysplasia (HP:0000110)	2.10625959
58	Microtia (HP:0008551)	2.07287143
59	Epistaxis (HP:0000421)	2.03456417
60	Alopecia of scalp (HP:0002293)	2.03016858
61	J-shaped sella turcica (HP:0002680)	2.02694728
62	Type 2 muscle fiber atrophy (HP:0003554)	2.02687528
63	Zonular cataract (HP:0010920)	2.00869256
64	Patchy hypopigmentation of hair (HP:0011365)	2.00428339
65	Pancreatic fibrosis (HP:0100732)	1.93666602
66	Nephronophthisis (HP:0000090)	1.90706442
67	Abnormality of the labia majora (HP:0012881)	1.90194800
68	High pitched voice (HP:0001620)	1.88996515
69	Tubulointerstitial nephritis (HP:0001970)	1.88165528
70	Nonprogressive disorder (HP:0003680)	1.87361996
71	Molar tooth sign on MRI (HP:0002419)	1.86677775
72	Abnormality of midbrain morphology (HP:0002418)	1.86677775
73	Optic nerve hypoplasia (HP:0000609)	1.86380638
74	Constricted visual fields (HP:0001133)	1.85678669
75	Febrile seizures (HP:0002373)	1.83584742
76	Conjugated hyperbilirubinemia (HP:0002908)	1.83529879
77	Abnormality of the renal cortex (HP:0011035)	1.81593161
78	Abnormality of the renal medulla (HP:0100957)	1.79444051
79	Bronchitis (HP:0012387)	1.78546869
80	Abnormality of the nasal mucosa (HP:0000433)	1.76881957
81	Enlarged penis (HP:0000040)	1.76312649
82	Pancreatic cysts (HP:0001737)	1.75679112
83	Gingival bleeding (HP:0000225)	1.75445794
84	Albinism (HP:0001022)	1.75151606
85	Renal cortical cysts (HP:0000803)	1.75123996
86	Photophobia (HP:0000613)	1.74798678
87	Infertility (HP:0000789)	1.74559526
88	Aortic regurgitation (HP:0001659)	1.73105593
89	Pachygyria (HP:0001302)	1.71784221
90	Broad alveolar ridges (HP:0000187)	1.70804251
91	Bulbous nose (HP:0000414)	1.70799892
92	Stridor (HP:0010307)	1.68305499
93	Aortic aneurysm (HP:0004942)	1.66728888
94	Nephrogenic diabetes insipidus (HP:0009806)	1.64269833
95	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.63050233
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.62695210
97	Widely spaced teeth (HP:0000687)	1.62067741
98	Atonic seizures (HP:0010819)	1.61987071
99	Abnormal platelet function (HP:0011869)	1.60560802
100	Impaired platelet aggregation (HP:0003540)	1.60560802

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.53271373
2	MST4	3.51752205
3	LATS1	3.17268483
4	BMPR1B	3.02592006
5	ACVR1B	2.94655685
6	FRK	2.87218891
7	STK16	2.82305914
8	TGFBR1	2.81387048
9	WNK3	2.62603549
10	BMX	2.38363613
11	MYLK	2.30074217
12	CAMK1G	2.20664803
13	MAP3K10	1.94969841
14	MARK1	1.94788011
15	PNCK	1.85582678
16	EPHA4	1.84350607
17	NUAK1	1.76135559
18	MARK3	1.75843473
19	PTK2B	1.73345822
20	TRIM28	1.71555114
21	GRK1	1.68417312
22	FER	1.62930772
23	MKNK1	1.46450713
24	CAMK1	1.42247603
25	PKN2	1.37603177
26	DYRK2	1.35525294
27	PAK3	1.35240419
28	NTRK3	1.32290583
29	TLK1	1.31466453
30	INSRR	1.31131557
31	MINK1	1.21563661
32	CAMK1D	1.19914832
33	MKNK2	1.18269233
34	FGR	1.16886283
35	BCR	1.15527665
36	MARK2	1.14194791
37	DYRK3	1.13335084
38	PHKG1	1.08917121
39	PHKG2	1.08917121
40	ILK	1.07113771
41	PINK1	1.06123067
42	PLK2	0.93806067
43	GRK5	0.91833535
44	STK3	0.91777160
45	TEC	0.91051324
46	IRAK1	0.89261945
47	DDR2	0.88792573
48	TYK2	0.88314941
49	BRD4	0.85292951
50	CAMK4	0.84192270
51	YES1	0.81607000
52	EPHA3	0.80936444
53	RET	0.80758204
54	WNK4	0.78688422
55	ADRBK2	0.75470997
56	CSNK1A1L	0.73522030
57	CAMKK2	0.71422762
58	MET	0.70705296
59	MAP3K11	0.69720690
60	MAPK13	0.68853992
61	BTK	0.68552726
62	ROCK1	0.66961714
63	STK24	0.65807911
64	OBSCN	0.62751124
65	PAK1	0.61675037
66	FLT3	0.61606073
67	CSF1R	0.60602598
68	FGFR2	0.60032556
69	SIK3	0.58504173
70	CSNK1G2	0.58450414
71	NLK	0.57563429
72	CSNK1G3	0.54939956
73	DYRK1A	0.54641689
74	PDGFRB	0.54555155
75	CDK8	0.54212330
76	ERBB2	0.53279042
77	AURKA	0.51273163
78	CAMK2A	0.49201550
79	ATM	0.48037581
80	MAPKAPK5	0.45154694
81	PDK1	0.44967242
82	RIPK4	0.44547706
83	HCK	0.44307862
84	PLK3	0.43860731
85	MAP2K6	0.42695181
86	ADRBK1	0.41757735
87	PKN1	0.39975272
88	GSK3A	0.39778960
89	PRKCG	0.39123740
90	MAP2K7	0.38955999
91	MAPK15	0.37809249
92	ZAK	0.33888100
93	SGK494	0.33385245
94	SGK223	0.33385245
95	PRKCQ	0.32981771
96	MELK	0.32955140
97	DAPK3	0.32737347
98	PRKCE	0.32305775
99	SGK3	0.31046171
100	PRKG1	0.30492031

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.41852817
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.18014726
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.84178738
4	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.71789611
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.48306337
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.45263638
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.24469968
8	Olfactory transduction_Homo sapiens_hsa04740	2.21057458
9	Platelet activation_Homo sapiens_hsa04611	2.15604975
10	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.15484286
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.11028275
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.93175857
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.85894066
14	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.68403009
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.63220512
16	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.60984099
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.51943032
18	Serotonergic synapse_Homo sapiens_hsa04726	1.46329766
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.42595819
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.42265682
21	Circadian entrainment_Homo sapiens_hsa04713	1.31981307
22	Cocaine addiction_Homo sapiens_hsa05030	1.30660560
23	GABAergic synapse_Homo sapiens_hsa04727	1.27728495
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.24419647
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23774495
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23637060
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.21370140
28	Morphine addiction_Homo sapiens_hsa05032	1.17156955
29	Circadian rhythm_Homo sapiens_hsa04710	1.16552241
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.16363251
31	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.15182807
32	Insulin secretion_Homo sapiens_hsa04911	1.15069886
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.14818589
34	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.13295809
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.10557327
36	Gap junction_Homo sapiens_hsa04540	1.09489653
37	PPAR signaling pathway_Homo sapiens_hsa03320	1.09144971
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.05824704
39	Taste transduction_Homo sapiens_hsa04742	1.04866169
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.04243340
41	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.99703625
42	Hippo signaling pathway_Homo sapiens_hsa04390	0.97326457
43	ECM-receptor interaction_Homo sapiens_hsa04512	0.94878630
44	Glycerolipid metabolism_Homo sapiens_hsa00561	0.93885422
45	Dopaminergic synapse_Homo sapiens_hsa04728	0.89983722
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.87429500
47	African trypanosomiasis_Homo sapiens_hsa05143	0.86582603
48	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.86104710
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.83156318
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.82679354
51	Butanoate metabolism_Homo sapiens_hsa00650	0.82260472
52	Retinol metabolism_Homo sapiens_hsa00830	0.80211433
53	Adherens junction_Homo sapiens_hsa04520	0.79824382
54	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.78570929
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.78294886
56	ABC transporters_Homo sapiens_hsa02010	0.76543415
57	Tight junction_Homo sapiens_hsa04530	0.73511694
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.73115166
59	Melanogenesis_Homo sapiens_hsa04916	0.70683787
60	Ras signaling pathway_Homo sapiens_hsa04014	0.70403512
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.70198560
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69952124
63	Nicotine addiction_Homo sapiens_hsa05033	0.69208487
64	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.68906588
65	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.66715721
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.66674590
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65350841
68	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.65085441
69	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.63670784
70	Bile secretion_Homo sapiens_hsa04976	0.63573029
71	Amphetamine addiction_Homo sapiens_hsa05031	0.63258894
72	Notch signaling pathway_Homo sapiens_hsa04330	0.61104595
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.59415951
74	Axon guidance_Homo sapiens_hsa04360	0.58957426
75	Endocytosis_Homo sapiens_hsa04144	0.57277218
76	Rap1 signaling pathway_Homo sapiens_hsa04015	0.55578983
77	Cholinergic synapse_Homo sapiens_hsa04725	0.55536781
78	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.55077428
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53632010
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.52777654
81	Alcoholism_Homo sapiens_hsa05034	0.52011485
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.51206638
83	Long-term depression_Homo sapiens_hsa04730	0.50863715
84	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.50601617
85	Pancreatic secretion_Homo sapiens_hsa04972	0.50405645
86	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.49763861
87	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48677507
88	Renin secretion_Homo sapiens_hsa04924	0.48168746
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47396181
90	Melanoma_Homo sapiens_hsa05218	0.45570634
91	Gastric acid secretion_Homo sapiens_hsa04971	0.45347400
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43595088
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41160575
94	Salivary secretion_Homo sapiens_hsa04970	0.40695005
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40489959
96	Chemokine signaling pathway_Homo sapiens_hsa04062	0.38829916
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.37758004
98	Oocyte meiosis_Homo sapiens_hsa04114	0.37658240
99	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.36915395
100	Focal adhesion_Homo sapiens_hsa04510	0.35447348

ENPP7P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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