ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	6.67896092
2	coenzyme catabolic process (GO:0009109)	6.17047688
3	positive regulation of catecholamine secretion (GO:0033605)	6.00802049
4	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	5.82529985
5	activation of protein kinase B activity (GO:0032148)	5.16337554
6	regulation of autophagic vacuole assembly (GO:2000785)	5.10241616
7	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.67484599
8	mRNA cleavage (GO:0006379)	4.43071201
9	ADP metabolic process (GO:0046031)	4.22763388
10	DNA double-strand break processing (GO:0000729)	4.15751644
11	motile cilium assembly (GO:0044458)	4.14995467
12	regulation of vacuole organization (GO:0044088)	4.09189256
13	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	4.06959543
14	negative regulation of striated muscle cell apoptotic process (GO:0010664)	4.02872877
15	response to muscle activity (GO:0014850)	3.97121005
16	relaxation of smooth muscle (GO:0044557)	3.96131500
17	tongue development (GO:0043586)	3.92795569
18	regulation of phospholipase A2 activity (GO:0032429)	3.91608179
19	AMP metabolic process (GO:0046033)	3.86147218
20	regulation of oxidative phosphorylation (GO:0002082)	3.81183903
21	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.80899077
22	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.78805868
23	DNA integration (GO:0015074)	3.77986285
24	protein localization to cell surface (GO:0034394)	3.76651768
25	cellular response to zinc ion (GO:0071294)	3.76088736
26	multicellular organism reproduction (GO:0032504)	3.74534759
27	regulation of oxidative stress-induced neuron death (GO:1903203)	3.73825665
28	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.73567037
29	cGMP-mediated signaling (GO:0019934)	3.68747752
30	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	3.66510656
31	positive regulation of protein kinase C signaling (GO:0090037)	3.65135065
32	regulation of cofactor metabolic process (GO:0051193)	3.50643297
33	regulation of coenzyme metabolic process (GO:0051196)	3.50643297
34	negative regulation of defense response to virus (GO:0050687)	3.45289472
35	diacylglycerol metabolic process (GO:0046339)	3.27604913
36	mesenchymal-epithelial cell signaling (GO:0060638)	3.24933279
37	regulation of keratinocyte proliferation (GO:0010837)	3.19124674
38	muscle fiber development (GO:0048747)	3.18158739
39	epithelial cilium movement (GO:0003351)	3.17589495
40	oligosaccharide biosynthetic process (GO:0009312)	3.15595629
41	axonemal dynein complex assembly (GO:0070286)	3.15204441
42	acrosome reaction (GO:0007340)	3.14216328
43	androgen biosynthetic process (GO:0006702)	3.13759045
44	TOR signaling (GO:0031929)	3.08198525
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.07788746
46	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.07633550
47	glycosphingolipid biosynthetic process (GO:0006688)	3.04414341
48	sulfation (GO:0051923)	3.00711164
49	nucleoside diphosphate biosynthetic process (GO:0009133)	2.98877216
50	paraxial mesoderm development (GO:0048339)	2.95198832
51	muscle cell cellular homeostasis (GO:0046716)	2.93357533
52	forebrain neuron differentiation (GO:0021879)	2.92234159
53	amino-acid betaine transport (GO:0015838)	2.92218693
54	carnitine transport (GO:0015879)	2.92218693
55	regulation of sulfur metabolic process (GO:0042762)	2.91931595
56	myelin assembly (GO:0032288)	2.89352726
57	glutamine family amino acid catabolic process (GO:0009065)	2.86652645
58	barbed-end actin filament capping (GO:0051016)	2.86294125
59	positive regulation of cGMP biosynthetic process (GO:0030828)	2.85729407
60	regulation of cellular respiration (GO:0043457)	2.84608547
61	negative regulation of neurological system process (GO:0031645)	2.84430527
62	cofactor catabolic process (GO:0051187)	2.84230932
63	negative regulation of DNA binding (GO:0043392)	2.81241642
64	otic vesicle formation (GO:0030916)	2.81203728
65	membrane tubulation (GO:0097320)	2.79902402
66	sperm motility (GO:0030317)	2.79258417
67	negative regulation of response to reactive oxygen species (GO:1901032)	2.78645661
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.78039236
69	regulation of cardiac muscle cell apoptotic process (GO:0010665)	2.75977764
70	L-serine transport (GO:0015825)	2.75642111
71	regulation of myoblast differentiation (GO:0045661)	2.75474285
72	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.73844105
73	axon extension involved in axon guidance (GO:0048846)	2.73844105
74	single fertilization (GO:0007338)	2.72081500
75	regulation of dopamine secretion (GO:0014059)	2.71801010
76	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.71366142
77	fibroblast migration (GO:0010761)	2.69930132
78	potassium ion export (GO:0071435)	2.69731027
79	radial glial cell differentiation (GO:0060019)	2.69369452
80	cellular response to cadmium ion (GO:0071276)	2.66470169
81	negative regulation of JNK cascade (GO:0046329)	2.66214892
82	embryonic camera-type eye development (GO:0031076)	2.64839086
83	thyroid gland development (GO:0030878)	2.63406482
84	regulation of cGMP biosynthetic process (GO:0030826)	2.63184300
85	C21-steroid hormone biosynthetic process (GO:0006700)	2.62120685
86	regulation of protein kinase C signaling (GO:0090036)	2.62111219
87	histone H3-K36 demethylation (GO:0070544)	2.61675712
88	response to nitrosative stress (GO:0051409)	2.59765244
89	cilium movement (GO:0003341)	2.59574753
90	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.58043653
91	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	2.56532322
92	negative regulation of macroautophagy (GO:0016242)	2.55621716
93	genitalia morphogenesis (GO:0035112)	2.54202018
94	negative regulation of smooth muscle cell proliferation (GO:0048662)	2.54002467
95	positive regulation of guanylate cyclase activity (GO:0031284)	2.53833875
96	nucleoside diphosphate phosphorylation (GO:0006165)	2.53729016
97	cellular zinc ion homeostasis (GO:0006882)	2.51552395
98	glycogen metabolic process (GO:0005977)	2.51430801
99	positive regulation of cGMP metabolic process (GO:0030825)	2.49576315
100	regulation of ARF GTPase activity (GO:0032312)	2.49435629

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.97278339
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.61504593
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	4.53399708
4	GBX2_23144817_ChIP-Seq_PC3_Human	4.25901906
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.74009583
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.69776461
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.21839502
8	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.09749445
9	VDR_22108803_ChIP-Seq_LS180_Human	2.61146867
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.35168040
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.32831215
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19192838
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.17575653
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.12057087
15	P300_19829295_ChIP-Seq_ESCs_Human	2.11607136
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.03665406
17	FUS_26573619_Chip-Seq_HEK293_Human	2.02830362
18	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.89233176
19	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.86913509
20	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.85030843
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.85030843
22	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.84462860
23	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.78946486
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.75550268
25	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.73853703
26	RXR_22108803_ChIP-Seq_LS180_Human	1.68220244
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.68203727
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.61501888
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61088786
30	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52564627
31	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.52549096
32	AHR_22903824_ChIP-Seq_MCF-7_Human	1.46066299
33	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.46000346
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43850988
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43500220
36	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.42159900
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41875481
38	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.41240536
39	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.40032320
40	CJUN_26792858_Chip-Seq_BT549_Human	1.40002812
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37481881
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37414244
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37414244
44	RUNX2_22187159_ChIP-Seq_PCA_Human	1.37159537
45	TP53_18474530_ChIP-ChIP_U2OS_Human	1.34419668
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30117850
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.29963912
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.29758751
49	AR_25329375_ChIP-Seq_VCAP_Human	1.29508835
50	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.29301990
51	EWS_26573619_Chip-Seq_HEK293_Human	1.29053084
52	STAT3_23295773_ChIP-Seq_U87_Human	1.28237002
53	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.27764900
54	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.26462224
55	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.26415407
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24964065
57	TBL1_22424771_ChIP-Seq_293T_Human	1.24311790
58	CDX2_22108803_ChIP-Seq_LS180_Human	1.24228058
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20775507
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.20478779
61	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20201770
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13028520
63	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.12915681
64	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.11216999
65	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.11137518
66	CBP_21632823_ChIP-Seq_H3396_Human	1.10727669
67	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.10491012
68	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.10491012
69	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.09967910
70	TCF4_23295773_ChIP-Seq_U87_Human	1.09505059
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09473017
72	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06968706
73	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.05874103
74	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05817160
75	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.05724820
76	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.02259373
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00344196
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99561427
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97673049
80	ERA_21632823_ChIP-Seq_H3396_Human	0.96501713
81	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95560322
82	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.94867440
83	TP53_16413492_ChIP-PET_HCT116_Human	0.94841182
84	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.94798945
85	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94580590
86	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94494014
87	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.92873965
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.92725804
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.92725804
90	BRD4_25478319_ChIP-Seq_HGPS_Human	0.91514641
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.91253998
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91202742
93	NFYB_21822215_ChIP-Seq_K562_Human	0.90491741
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.89542005
95	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89001424
96	TAF15_26573619_Chip-Seq_HEK293_Human	0.87621700
97	EOMES_21245162_ChIP-Seq_HESCs_Human	0.86480987
98	ELF5_23300383_ChIP-Seq_T47D_Human	0.86107741
99	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.85629701
100	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.85338495

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008004_abnormal_stomach_pH	4.99790398
2	MP0003315_abnormal_perineum_morphology	3.62402914
3	MP0002102_abnormal_ear_morphology	3.45476257
4	MP0001984_abnormal_olfaction	3.30682895
5	MP0003806_abnormal_nucleotide_metabolis	3.21711692
6	MP0005394_taste/olfaction_phenotype	3.05239708
7	MP0005499_abnormal_olfactory_system	3.05239708
8	MP0004272_abnormal_basement_membrane	2.90595122
9	MP0002160_abnormal_reproductive_system	2.68436986
10	MP0002837_dystrophic_cardiac_calcinosis	2.62946697
11	MP0004084_abnormal_cardiac_muscle	2.51711415
12	MP0000749_muscle_degeneration	2.51678157
13	MP0003136_yellow_coat_color	2.37237723
14	MP0003890_abnormal_embryonic-extraembry	2.25555044
15	MP0005187_abnormal_penis_morphology	2.22069362
16	MP0005410_abnormal_fertilization	2.18461749
17	MP0001529_abnormal_vocalization	2.16387556
18	MP0006072_abnormal_retinal_apoptosis	2.13658531
19	MP0010368_abnormal_lymphatic_system	2.07360301
20	MP0002127_abnormal_cardiovascular_syste	2.05742290
21	MP0009697_abnormal_copulation	2.02140996
22	MP0002132_abnormal_respiratory_system	2.01121015
23	MP0010386_abnormal_urinary_bladder	2.00354402
24	MP0009840_abnormal_foam_cell	1.78793371
25	MP0001849_ear_inflammation	1.73921322
26	MP0004133_heterotaxia	1.70189488
27	MP0004036_abnormal_muscle_relaxation	1.64256618
28	MP0000537_abnormal_urethra_morphology	1.63067900
29	MP0003385_abnormal_body_wall	1.61666511
30	MP0004381_abnormal_hair_follicle	1.59638364
31	MP0005646_abnormal_pituitary_gland	1.59286368
32	MP0005330_cardiomyopathy	1.58367733
33	MP0005248_abnormal_Harderian_gland	1.54041967
34	MP0008789_abnormal_olfactory_epithelium	1.46926612
35	MP0002254_reproductive_system_inflammat	1.45583257
36	MP0002233_abnormal_nose_morphology	1.43928715
37	MP0001485_abnormal_pinna_reflex	1.42828823
38	MP0004215_abnormal_myocardial_fiber	1.40700419
39	MP0004264_abnormal_extraembryonic_tissu	1.39998460
40	MP0002108_abnormal_muscle_morphology	1.37828837
41	MP0005253_abnormal_eye_physiology	1.36814154
42	MP0001270_distended_abdomen	1.34688191
43	MP0001664_abnormal_digestion	1.30191258
44	MP0005620_abnormal_muscle_contractility	1.26642737
45	MP0009780_abnormal_chondrocyte_physiolo	1.25941969
46	MP0005389_reproductive_system_phenotype	1.23973390
47	MP0000049_abnormal_middle_ear	1.20573553
48	MP0005551_abnormal_eye_electrophysiolog	1.19999510
49	MP0000538_abnormal_urinary_bladder	1.18955675
50	MP0009250_abnormal_appendicular_skeleto	1.15780310
51	MP0006036_abnormal_mitochondrial_physio	1.14052354
52	MP0001188_hyperpigmentation	1.13435812
53	MP0002269_muscular_atrophy	1.10344958
54	MP0001299_abnormal_eye_distance/	1.05270487
55	MP0001661_extended_life_span	1.03939923
56	MP0003936_abnormal_reproductive_system	1.03665730
57	MP0000762_abnormal_tongue_morphology	1.03350318
58	MP0004484_altered_response_of	1.02138434
59	MP0002295_abnormal_pulmonary_circulatio	0.98939517
60	MP0009046_muscle_twitch	0.98557102
61	MP0004085_abnormal_heartbeat	0.97766769
62	MP0003880_abnormal_central_pattern	0.97084244
63	MP0003698_abnormal_male_reproductive	0.96742600
64	MP0005647_abnormal_sex_gland	0.95311868
65	MP0010030_abnormal_orbit_morphology	0.94899325
66	MP0008775_abnormal_heart_ventricle	0.93940987
67	MP0001486_abnormal_startle_reflex	0.92115583
68	MP0002115_abnormal_skeleton_extremities	0.91410804
69	MP0001929_abnormal_gametogenesis	0.89374058
70	MP0002184_abnormal_innervation	0.89200521
71	MP0005360_urolithiasis	0.83865994
72	MP0003935_abnormal_craniofacial_develop	0.83101290
73	MP0005595_abnormal_vascular_smooth	0.82680875
74	MP0002752_abnormal_somatic_nervous	0.81636360
75	MP0003937_abnormal_limbs/digits/tail_de	0.80611502
76	MP0006138_congestive_heart_failure	0.80013897
77	MP0005391_vision/eye_phenotype	0.79474521
78	MP0003755_abnormal_palate_morphology	0.79335705
79	MP0001764_abnormal_homeostasis	0.79286703
80	MP0002090_abnormal_vision	0.78872875
81	MP0002972_abnormal_cardiac_muscle	0.78235781
82	MP0000462_abnormal_digestive_system	0.77734794
83	MP0000026_abnormal_inner_ear	0.76433665
84	MP0003567_abnormal_fetal_cardiomyocyte	0.75913581
85	MP0002272_abnormal_nervous_system	0.75196146
86	MP0003119_abnormal_digestive_system	0.71677316
87	MP0001986_abnormal_taste_sensitivity	0.69738857
88	MP0000230_abnormal_systemic_arterial	0.68731386
89	MP0001919_abnormal_reproductive_system	0.67684220
90	MP0005171_absent_coat_pigmentation	0.66534967
91	MP0001905_abnormal_dopamine_level	0.66209434
92	MP0003941_abnormal_skin_development	0.65048700
93	MP0003938_abnormal_ear_development	0.62792089
94	MP0002876_abnormal_thyroid_physiology	0.61972931
95	MP0004134_abnormal_chest_morphology	0.59921280
96	MP0005386_behavior/neurological_phenoty	0.59767096
97	MP0004924_abnormal_behavior	0.59767096
98	MP0001963_abnormal_hearing_physiology	0.58787836
99	MP0004087_abnormal_muscle_fiber	0.57840686
100	MP0001968_abnormal_touch/_nociception	0.56255369

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced antithrombin III activity (HP:0001976)	5.35957200
2	Abnormality of the columella (HP:0009929)	4.66307035
3	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	4.20669583
4	Resting tremor (HP:0002322)	3.58046512
5	Intestinal atresia (HP:0011100)	3.52407426
6	Hyporeflexia of lower limbs (HP:0002600)	3.43830437
7	Abnormality of the frontal sinuses (HP:0002687)	3.33261002
8	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	3.22921300
9	Sensory axonal neuropathy (HP:0003390)	3.19059032
10	Cerebellar dysplasia (HP:0007033)	3.12231397
11	Abnormality of the shoulder girdle musculature (HP:0001435)	2.95394856
12	Congenital malformation of the right heart (HP:0011723)	2.94424562
13	Double outlet right ventricle (HP:0001719)	2.94424562
14	Aortic aneurysm (HP:0004942)	2.91949610
15	Clumsiness (HP:0002312)	2.83352928
16	Type II lissencephaly (HP:0007260)	2.80487689
17	Hypothermia (HP:0002045)	2.79580298
18	Pigmentary retinal degeneration (HP:0001146)	2.73331794
19	Gonadal dysgenesis (HP:0000133)	2.71015449
20	True hermaphroditism (HP:0010459)	2.70980431
21	Absent radius (HP:0003974)	2.70356079
22	Inability to walk (HP:0002540)	2.67114011
23	High anterior hairline (HP:0009890)	2.64428997
24	Aqueductal stenosis (HP:0002410)	2.63581957
25	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.63082377
26	Abnormal ciliary motility (HP:0012262)	2.61123387
27	Thoracolumbar scoliosis (HP:0002944)	2.60551252
28	Esophageal atresia (HP:0002032)	2.58578742
29	Abnormal respiratory motile cilium physiology (HP:0012261)	2.56419186
30	Aplasia involving forearm bones (HP:0009822)	2.56356770
31	Absent forearm bone (HP:0003953)	2.56356770
32	Male pseudohermaphroditism (HP:0000037)	2.54362643
33	Abnormality of the intrinsic pathway (HP:0010989)	2.51802741
34	Facial hemangioma (HP:0000329)	2.49735032
35	Self-mutilation (HP:0000742)	2.45621399
36	Occipital encephalocele (HP:0002085)	2.43149069
37	Chronic hepatic failure (HP:0100626)	2.39214269
38	Thoracic kyphosis (HP:0002942)	2.39066589
39	Atonic seizures (HP:0010819)	2.37299369
40	Hypoplasia of the uterus (HP:0000013)	2.37294537
41	Scapular winging (HP:0003691)	2.27179993
42	Bifid scrotum (HP:0000048)	2.26857660
43	Retinal dysplasia (HP:0007973)	2.25647800
44	Capillary hemangiomas (HP:0005306)	2.25386360
45	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.25043294
46	Absent/shortened dynein arms (HP:0200106)	2.25043294
47	Spinal rigidity (HP:0003306)	2.23804434
48	Muscular dystrophy (HP:0003560)	2.21769216
49	Abnormality of the incisor (HP:0000676)	2.19696078
50	Bile duct proliferation (HP:0001408)	2.19583038
51	Abnormal biliary tract physiology (HP:0012439)	2.19583038
52	Postural instability (HP:0002172)	2.18712080
53	Pancreatic cysts (HP:0001737)	2.18531500
54	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.17909197
55	Abnormal protein N-linked glycosylation (HP:0012347)	2.17909197
56	Abnormal protein glycosylation (HP:0012346)	2.17909197
57	Abnormal glycosylation (HP:0012345)	2.17909197
58	Urinary urgency (HP:0000012)	2.14612512
59	Abnormal pancreas size (HP:0012094)	2.13093631
60	Median cleft lip (HP:0000161)	2.11737731
61	Gonadotropin excess (HP:0000837)	2.11016252
62	Supernumerary spleens (HP:0009799)	2.09362909
63	Gastrointestinal atresia (HP:0002589)	2.06787517
64	Cupped ear (HP:0000378)	2.06625937
65	Optic nerve hypoplasia (HP:0000609)	2.04281006
66	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04106869
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.03683581
68	Right ventricular cardiomyopathy (HP:0011663)	2.03471164
69	Anterior segment dysgenesis (HP:0007700)	2.02316652
70	Poor head control (HP:0002421)	2.02021785
71	Ureteral duplication (HP:0000073)	2.01240257
72	Ventricular fibrillation (HP:0001663)	2.00377523
73	Vitreoretinal degeneration (HP:0000655)	1.99569931
74	Anencephaly (HP:0002323)	1.99503622
75	Sex reversal (HP:0012245)	1.99224843
76	Abnormal sex determination (HP:0012244)	1.99224843
77	Pancreatic fibrosis (HP:0100732)	1.98916145
78	Unsteady gait (HP:0002317)	1.98830083
79	Progressive inability to walk (HP:0002505)	1.96348843
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94848843
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.94848843
82	Oligodactyly (hands) (HP:0001180)	1.94126399
83	Protruding tongue (HP:0010808)	1.92273627
84	Proximal amyotrophy (HP:0007126)	1.92034936
85	Dyschromatopsia (HP:0007641)	1.91826527
86	Exercise-induced muscle cramps (HP:0003710)	1.91131236
87	Eosinophilia (HP:0001880)	1.90377126
88	Aplasia/hypoplasia of the humerus (HP:0006507)	1.89516251
89	Mixed hearing impairment (HP:0000410)	1.88868694
90	Aplasia involving bones of the extremities (HP:0009825)	1.86483033
91	Aplasia involving bones of the upper limbs (HP:0009823)	1.86483033
92	Aplasia of the phalanges of the hand (HP:0009802)	1.86483033
93	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84976605
94	Abnormality of the calf musculature (HP:0001430)	1.84416232
95	Abnormality of the ileum (HP:0001549)	1.82246951
96	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.79826327
97	Aplasia cutis congenita (HP:0001057)	1.79775865
98	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.78721645
99	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77485936
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.77085300

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	8.03925837
2	MARK3	3.93474659
3	LATS1	3.62484572
4	MYLK	3.49039769
5	MAP2K7	2.89288202
6	STK38L	2.88333897
7	OBSCN	2.69393779
8	NEK2	2.67727821
9	BMPR1B	2.62679898
10	FRK	2.19730057
11	ZAK	1.99411803
12	ERBB4	1.85500446
13	CSNK1A1L	1.84044754
14	EIF2AK3	1.61545772
15	PBK	1.56924421
16	WNK3	1.56771511
17	PKN2	1.52452504
18	CSNK1G3	1.51844643
19	LATS2	1.49500941
20	NLK	1.49499476
21	DYRK3	1.49388341
22	GRK1	1.46962193
23	CSNK1G1	1.33158122
24	SGK494	1.31839180
25	SGK223	1.31839180
26	TLK1	1.30452434
27	CDK3	1.28566376
28	STK38	1.19986346
29	MAPKAPK3	1.17292711
30	MAPK13	1.16865858
31	CSNK1G2	1.16673513
32	FGFR2	1.16230362
33	AKT3	1.12422979
34	CLK1	1.10614460
35	TGFBR1	1.08510999
36	MAP4K2	1.05749656
37	ACVR1B	1.02544672
38	PRKD3	0.99728946
39	MELK	0.93177505
40	SGK2	0.89757296
41	TIE1	0.86504808
42	RPS6KB1	0.84634591
43	PRKCQ	0.84603266
44	TRIM28	0.84101903
45	MAP3K9	0.81652326
46	IRAK2	0.76986388
47	ADRBK2	0.76767660
48	TXK	0.75518741
49	PDK2	0.75123658
50	PRKG2	0.72532298
51	ARAF	0.72380707
52	MAP3K4	0.72243511
53	MAP3K5	0.69869117
54	NME2	0.69822078
55	ERBB3	0.69651570
56	FLT3	0.69205902
57	MAP3K1	0.66733044
58	RPS6KA4	0.65589200
59	CCNB1	0.63689724
60	MAP3K13	0.62041970
61	RPS6KA5	0.60581646
62	ROCK1	0.60226522
63	MOS	0.59657552
64	DAPK3	0.57740891
65	PAK1	0.56312103
66	MAPK15	0.55697631
67	CASK	0.53074255
68	CDK14	0.46895191
69	EEF2K	0.45407013
70	PTK2B	0.44840719
71	EGFR	0.43837269
72	SGK3	0.41532667
73	GRK5	0.41307547
74	MAP3K12	0.40894005
75	TNIK	0.39903276
76	RET	0.39876277
77	WEE1	0.39474465
78	MINK1	0.37470987
79	PRKCE	0.36992224
80	MKNK2	0.36035965
81	CSNK1A1	0.34497587
82	CDK8	0.31747667
83	PAK2	0.31717598
84	PAK3	0.31713438
85	CAMK1	0.30814483
86	ATM	0.30141782
87	AKT2	0.28768549
88	PRKG1	0.28438412
89	BCR	0.27428558
90	PLK1	0.26476651
91	MST1R	0.25668294
92	EPHA4	0.24641922
93	ADRBK1	0.24402164
94	MAPKAPK5	0.22865118
95	CDK5	0.20163590
96	CDC42BPA	0.19732268
97	ICK	0.18915893
98	CAMK2B	0.18229576
99	TAOK3	0.16615192
100	PRKAA1	0.16048233

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	3.79125789
2	Butanoate metabolism_Homo sapiens_hsa00650	3.38736649
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.36735277
4	Phototransduction_Homo sapiens_hsa04744	2.91614503
5	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.82281647
6	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.21412921
7	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.12463524
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.04218156
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.01650524
10	Circadian rhythm_Homo sapiens_hsa04710	1.99653411
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.89768340
12	beta-Alanine metabolism_Homo sapiens_hsa00410	1.74843316
13	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.71366310
14	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.61423207
15	Arginine biosynthesis_Homo sapiens_hsa00220	1.56440713
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.54912029
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.53441331
18	Taste transduction_Homo sapiens_hsa04742	1.51946815
19	Regulation of autophagy_Homo sapiens_hsa04140	1.50838028
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.49181615
21	Gap junction_Homo sapiens_hsa04540	1.48382642
22	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.46213883
23	Propanoate metabolism_Homo sapiens_hsa00640	1.45444209
24	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.45433802
25	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.43367643
26	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.39429785
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34254476
28	Renin secretion_Homo sapiens_hsa04924	1.30458024
29	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.29249192
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.28865490
31	Circadian entrainment_Homo sapiens_hsa04713	1.28824524
32	Salivary secretion_Homo sapiens_hsa04970	1.28297858
33	Calcium signaling pathway_Homo sapiens_hsa04020	1.27474419
34	Wnt signaling pathway_Homo sapiens_hsa04310	1.26210163
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.22899464
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.19149330
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.16900546
38	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.07477769
39	GABAergic synapse_Homo sapiens_hsa04727	1.06470628
40	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.03632304
41	Pyruvate metabolism_Homo sapiens_hsa00620	1.02825190
42	Alcoholism_Homo sapiens_hsa05034	1.02064150
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.01392272
44	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.95736845
45	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.95342606
46	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.95303434
47	Gastric acid secretion_Homo sapiens_hsa04971	0.95179991
48	Basal transcription factors_Homo sapiens_hsa03022	0.93118566
49	ABC transporters_Homo sapiens_hsa02010	0.90389576
50	Glucagon signaling pathway_Homo sapiens_hsa04922	0.86912670
51	Purine metabolism_Homo sapiens_hsa00230	0.86389370
52	PPAR signaling pathway_Homo sapiens_hsa03320	0.85796120
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.84510370
54	Glutathione metabolism_Homo sapiens_hsa00480	0.83108181
55	Peroxisome_Homo sapiens_hsa04146	0.82926996
56	Nicotine addiction_Homo sapiens_hsa05033	0.82233215
57	Melanogenesis_Homo sapiens_hsa04916	0.82014207
58	Oocyte meiosis_Homo sapiens_hsa04114	0.73676467
59	Hippo signaling pathway_Homo sapiens_hsa04390	0.72937456
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.72786744
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68866482
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68489402
63	Melanoma_Homo sapiens_hsa05218	0.66155026
64	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.65581585
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63893656
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63374914
67	Amphetamine addiction_Homo sapiens_hsa05031	0.63027817
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59646770
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59504414
70	RNA degradation_Homo sapiens_hsa03018	0.58039769
71	Retinol metabolism_Homo sapiens_hsa00830	0.57211291
72	Mineral absorption_Homo sapiens_hsa04978	0.56811666
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55704803
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.54737551
75	Fatty acid degradation_Homo sapiens_hsa00071	0.52174027
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.50279963
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.50012081
78	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49949445
79	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47384179
80	ECM-receptor interaction_Homo sapiens_hsa04512	0.47371972
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47344075
82	Caffeine metabolism_Homo sapiens_hsa00232	0.47310539
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.47032095
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46298662
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.44626687
86	AMPK signaling pathway_Homo sapiens_hsa04152	0.43892060
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43795620
88	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.43236603
89	Phenylalanine metabolism_Homo sapiens_hsa00360	0.42650269
90	Endometrial cancer_Homo sapiens_hsa05213	0.41480608
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40201934
92	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.39004134
93	Prostate cancer_Homo sapiens_hsa05215	0.38894656
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38225633
95	Tryptophan metabolism_Homo sapiens_hsa00380	0.37936095
96	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.37859247
97	Histidine metabolism_Homo sapiens_hsa00340	0.37628963
98	Phagosome_Homo sapiens_hsa04145	0.36205301
99	Metabolic pathways_Homo sapiens_hsa01100	0.36086057
100	Morphine addiction_Homo sapiens_hsa05032	0.35583201

ENPP7P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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