ENPP7P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interleukin-1-mediated signaling pathway (GO:0070498)8.39365552
2positive regulation of prostaglandin secretion (GO:0032308)8.12870218
3regulation of heat generation (GO:0031650)7.04331884
4regulation of prostaglandin secretion (GO:0032306)6.89324901
5regulation of interleukin-12 biosynthetic process (GO:0045075)6.81656619
6positive regulation of heat generation (GO:0031652)6.48250942
7regulation of fever generation (GO:0031620)6.35311763
8bone resorption (GO:0045453)5.49307382
9positive regulation of icosanoid secretion (GO:0032305)5.47622379
10positive regulation of fatty acid transport (GO:2000193)5.38969186
11mitochondrion transport along microtubule (GO:0047497)5.10813113
12establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.10813113
13establishment of mitochondrion localization (GO:0051654)5.08531546
14regulation of immunoglobulin secretion (GO:0051023)4.89021083
15positive regulation of T cell cytokine production (GO:0002726)4.75770992
16response to lipoprotein particle (GO:0055094)4.64996685
17mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.64531775
18positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.64531775
19positive regulation of osteoclast differentiation (GO:0045672)4.42873349
20T-helper 1 type immune response (GO:0042088)4.14783509
21regulation of icosanoid secretion (GO:0032303)4.06480905
22toxin transport (GO:1901998)4.03489996
23histone H3-K36 demethylation (GO:0070544)4.02411423
24regulation of energy homeostasis (GO:2000505)3.83746152
25positive regulation of transcription regulatory region DNA binding (GO:2000679)3.82916007
26amyloid precursor protein catabolic process (GO:0042987)3.80388852
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.79734799
28sulfur amino acid catabolic process (GO:0000098)3.79721769
29galactose catabolic process (GO:0019388)3.78735216
30protein-cofactor linkage (GO:0018065)3.71123364
31rRNA catabolic process (GO:0016075)3.66007740
32phospholipid homeostasis (GO:0055091)3.65148129
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.64669156
34positive regulation of organic acid transport (GO:0032892)3.60273669
35regulation of skeletal muscle cell differentiation (GO:2001014)3.42730568
36regulation of T cell cytokine production (GO:0002724)3.42693968
37epithelial cilium movement (GO:0003351)3.40015644
38regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.39290922
39sulfation (GO:0051923)3.39199549
40regulation of rhodopsin mediated signaling pathway (GO:0022400)3.37425594
41cerebral cortex radially oriented cell migration (GO:0021799)3.36826398
42alkaloid metabolic process (GO:0009820)3.31837920
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30418286
44aspartate family amino acid biosynthetic process (GO:0009067)3.30148388
45germ cell migration (GO:0008354)3.28670898
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.27887907
47positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.25029755
48rhodopsin mediated signaling pathway (GO:0016056)3.21886335
49neuron cell-cell adhesion (GO:0007158)3.21386049
50synaptic transmission, cholinergic (GO:0007271)3.17977812
51regulation of male gonad development (GO:2000018)3.15623450
52L-methionine biosynthetic process (GO:0071265)3.15120576
53amino acid salvage (GO:0043102)3.15120576
54L-methionine salvage (GO:0071267)3.15120576
55peptidyl-threonine dephosphorylation (GO:0035970)3.11391579
56regulation of mitotic spindle checkpoint (GO:1903504)3.10642332
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10642332
58behavioral response to nicotine (GO:0035095)3.05919459
59positive regulation of bone resorption (GO:0045780)3.05439116
60positive regulation of bone remodeling (GO:0046852)3.05439116
61regulation of cholesterol esterification (GO:0010872)3.03986555
62osteoclast differentiation (GO:0030316)3.02184743
63branched-chain amino acid catabolic process (GO:0009083)2.95188066
64cellular ketone body metabolic process (GO:0046950)2.92367469
65negative regulation of heart rate (GO:0010459)2.91214140
66low-density lipoprotein particle remodeling (GO:0034374)2.91113129
67cellular response to nicotine (GO:0071316)2.90942405
68cerebral cortex cell migration (GO:0021795)2.90257656
69seminiferous tubule development (GO:0072520)2.85768722
70protein polyglutamylation (GO:0018095)2.85671131
71intracellular lipid transport (GO:0032365)2.84457804
72ADP metabolic process (GO:0046031)2.81784489
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.81425423
74mitotic cell cycle arrest (GO:0071850)2.80408050
75mammary gland alveolus development (GO:0060749)2.79987469
76pyrimidine nucleotide catabolic process (GO:0006244)2.74168598
77outer ear morphogenesis (GO:0042473)2.72640559
78negative regulation of multicellular organism growth (GO:0040015)2.68388980
79positive regulation of cardiac muscle cell differentiation (GO:2000727)2.67953742
80synapse assembly (GO:0007416)2.67224045
81dopamine biosynthetic process (GO:0042416)2.63192585
82base-excision repair, AP site formation (GO:0006285)2.63088207
83regulation of transcription regulatory region DNA binding (GO:2000677)2.61242307
84negative regulation of neural precursor cell proliferation (GO:2000178)2.61156035
85amyloid precursor protein metabolic process (GO:0042982)2.59191745
86establishment of protein localization to Golgi (GO:0072600)2.58206855
87protein localization to synapse (GO:0035418)2.58096830
88ketone body metabolic process (GO:1902224)2.56924669
89monocyte chemotaxis (GO:0002548)2.56694336
90tumor necrosis factor-mediated signaling pathway (GO:0033209)2.56328584
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.54645349
92protein insertion into membrane (GO:0051205)2.53236312
93mammary gland epithelial cell proliferation (GO:0033598)2.52482348
94phospholipid efflux (GO:0033700)2.50766817
95C4-dicarboxylate transport (GO:0015740)2.50658748
96positive regulation of mitochondrial membrane permeability (GO:0035794)2.50053104
97regulation of interleukin-6 biosynthetic process (GO:0045408)2.46571471
98platelet dense granule organization (GO:0060155)2.46136200
99endoderm formation (GO:0001706)2.45948096
100positive regulation of male gonad development (GO:2000020)2.45535491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.98911259
2ZNF274_21170338_ChIP-Seq_K562_Hela3.93088493
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.73322617
4VDR_22108803_ChIP-Seq_LS180_Human3.66024057
5TAF15_26573619_Chip-Seq_HEK293_Human2.73288694
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67161642
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52930564
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.48683451
9EZH2_22144423_ChIP-Seq_EOC_Human2.47498572
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36094084
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30243531
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24042799
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15813779
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09440680
15CBP_20019798_ChIP-Seq_JUKART_Human2.07117572
16IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.07117572
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02648863
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.97033636
19IGF1R_20145208_ChIP-Seq_DFB_Human1.94681878
20BCAT_22108803_ChIP-Seq_LS180_Human1.88106873
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78710697
22MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73916226
23ER_23166858_ChIP-Seq_MCF-7_Human1.72481762
24P300_19829295_ChIP-Seq_ESCs_Human1.72081166
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69240761
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68000097
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.67694464
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66377331
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65880010
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64854957
31EGR1_19032775_ChIP-ChIP_M12_Human1.58040029
32EWS_26573619_Chip-Seq_HEK293_Human1.57992410
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57499016
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52006431
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48646544
36TCF4_23295773_ChIP-Seq_U87_Human1.45137172
37HTT_18923047_ChIP-ChIP_STHdh_Human1.43784862
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42397590
39MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40205151
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39941989
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39878027
42STAT3_23295773_ChIP-Seq_U87_Human1.38685833
43TCF4_22108803_ChIP-Seq_LS180_Human1.38348389
44REST_21632747_ChIP-Seq_MESCs_Mouse1.35886290
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.35600653
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34817557
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33948342
48SMAD4_21799915_ChIP-Seq_A2780_Human1.33409977
49TP53_22573176_ChIP-Seq_HFKS_Human1.32534304
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32303044
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.31284664
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29443111
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27768667
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25744430
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.25331037
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25318579
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24580801
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24516767
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23727989
60RUNX2_22187159_ChIP-Seq_PCA_Human1.21732073
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.18495257
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14597700
63AR_25329375_ChIP-Seq_VCAP_Human1.13515938
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.12488631
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12360748
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11764006
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.11028794
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10839073
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09382047
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08222528
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08036635
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07944690
73TBL1_22424771_ChIP-Seq_293T_Human1.06894629
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.06774378
75FUS_26573619_Chip-Seq_HEK293_Human1.06329319
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06320389
77KDM2B_26808549_Chip-Seq_REH_Human1.04749557
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.03307797
79NANOG_19829295_ChIP-Seq_ESCs_Human1.02731565
80SOX2_19829295_ChIP-Seq_ESCs_Human1.02731565
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02429473
82WDR5_24793694_ChIP-Seq_LNCAP_Human1.01091418
83SMAD3_21741376_ChIP-Seq_ESCs_Human1.00848593
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00812513
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.00699124
86HOXB7_26014856_ChIP-Seq_BT474_Human0.96776026
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96549469
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94327326
89MYC_19829295_ChIP-Seq_ESCs_Human0.92020953
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91311189
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91001813
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90299502
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.90299502
94RNF2_27304074_Chip-Seq_NSC_Mouse0.90228060
95JUN_21703547_ChIP-Seq_K562_Human0.89217737
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88640065
97GATA3_26560356_Chip-Seq_TH2_Human0.88329303
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87495950
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87495950
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86948836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph4.80987723
2MP0002822_catalepsy4.43197599
3MP0000569_abnormal_digit_pigmentation2.99504780
4MP0005187_abnormal_penis_morphology2.99227768
5MP0003195_calcinosis2.60914280
6MP0001529_abnormal_vocalization2.58583177
7MP0004859_abnormal_synaptic_plasticity2.46515539
8MP0002837_dystrophic_cardiac_calcinosis2.44117760
9MP0009840_abnormal_foam_cell2.39706992
10MP0004782_abnormal_surfactant_physiolog2.39413727
11MP0000427_abnormal_hair_cycle2.38839820
12MP0003724_increased_susceptibility_to2.37900878
13MP0004133_heterotaxia2.35684006
14MP0000383_abnormal_hair_follicle2.25223059
15MP0002095_abnormal_skin_pigmentation2.24168121
16MP0002909_abnormal_adrenal_gland2.22127478
17MP0002938_white_spotting2.12187489
18MP0009384_cardiac_valve_regurgitation2.01301561
19MP0005551_abnormal_eye_electrophysiolog1.94193531
20MP0003880_abnormal_central_pattern1.90014424
21MP0000685_abnormal_immune_system1.87121570
22MP0000647_abnormal_sebaceous_gland1.84412901
23MP0001188_hyperpigmentation1.83823071
24MP0003436_decreased_susceptibility_to1.68771196
25MP0000049_abnormal_middle_ear1.58978775
26MP0005646_abnormal_pituitary_gland1.57111999
27MP0002102_abnormal_ear_morphology1.56377034
28MP0008789_abnormal_olfactory_epithelium1.54623551
29MP0001486_abnormal_startle_reflex1.52328800
30MP0008775_abnormal_heart_ventricle1.50346775
31MP0001984_abnormal_olfaction1.49718152
32MP0001764_abnormal_homeostasis1.47890824
33MP0004142_abnormal_muscle_tone1.46919072
34MP0004742_abnormal_vestibular_system1.41845218
35MP0002405_respiratory_system_inflammati1.33730562
36MP0002063_abnormal_learning/memory/cond1.32793367
37MP0002234_abnormal_pharynx_morphology1.32365846
38MP0000230_abnormal_systemic_arterial1.31469766
39MP0010678_abnormal_skin_adnexa1.30433423
40MP0009745_abnormal_behavioral_response1.29252812
41MP0001502_abnormal_circadian_rhythm1.25627061
42MP0002272_abnormal_nervous_system1.24668002
43MP0002638_abnormal_pupillary_reflex1.23280807
44MP0002064_seizures1.20057485
45MP0009046_muscle_twitch1.18435565
46MP0005535_abnormal_body_temperature1.18316425
47MP0002229_neurodegeneration1.16710611
48MP0000013_abnormal_adipose_tissue1.16108861
49MP0010030_abnormal_orbit_morphology1.15106867
50MP0001968_abnormal_touch/_nociception1.13264306
51MP0002736_abnormal_nociception_after1.12822500
52MP0002148_abnormal_hypersensitivity_rea1.11640817
53MP0000639_abnormal_adrenal_gland1.11263449
54MP0003635_abnormal_synaptic_transmissio1.10552410
55MP0001440_abnormal_grooming_behavior1.08750484
56MP0003787_abnormal_imprinting1.07943916
57MP0003191_abnormal_cellular_cholesterol1.07506332
58MP0008875_abnormal_xenobiotic_pharmacok1.05470944
59MP0005253_abnormal_eye_physiology1.05423769
60MP0001485_abnormal_pinna_reflex1.05316593
61MP0005394_taste/olfaction_phenotype1.02722328
62MP0005499_abnormal_olfactory_system1.02722328
63MP0000538_abnormal_urinary_bladder1.02479211
64MP0005085_abnormal_gallbladder_physiolo1.01242341
65MP0005377_hearing/vestibular/ear_phenot1.01106023
66MP0003878_abnormal_ear_physiology1.01106023
67MP0000470_abnormal_stomach_morphology1.00792359
68MP0009115_abnormal_fat_cell1.00766420
69MP0001905_abnormal_dopamine_level0.99688027
70MP0003011_delayed_dark_adaptation0.99037333
71MP0001533_abnormal_skeleton_physiology0.97951307
72MP0002067_abnormal_sensory_capabilities0.96818495
73MP0002752_abnormal_somatic_nervous0.96068516
74MP0002751_abnormal_autonomic_nervous0.94637833
75MP0008569_lethality_at_weaning0.93006042
76MP0002557_abnormal_social/conspecific_i0.92125134
77MP0001501_abnormal_sleep_pattern0.91311651
78MP0003119_abnormal_digestive_system0.88299125
79MP0005386_behavior/neurological_phenoty0.85602096
80MP0004924_abnormal_behavior0.85602096
81MP0000778_abnormal_nervous_system0.81456187
82MP0009250_abnormal_appendicular_skeleto0.81038872
83MP0005448_abnormal_energy_balance0.80174250
84MP0002177_abnormal_outer_ear0.79860675
85MP0005248_abnormal_Harderian_gland0.78908117
86MP0002069_abnormal_eating/drinking_beha0.78743989
87MP0001324_abnormal_eye_pigmentation0.78230147
88MP0002098_abnormal_vibrissa_morphology0.77875557
89MP0006276_abnormal_autonomic_nervous0.77869839
90MP0004043_abnormal_pH_regulation0.77175419
91MP0002127_abnormal_cardiovascular_syste0.74865169
92MP0003937_abnormal_limbs/digits/tail_de0.74509363
93MP0002572_abnormal_emotion/affect_behav0.74365866
94MP0002882_abnormal_neuron_morphology0.74035681
95MP0004270_analgesia0.73907210
96MP0000026_abnormal_inner_ear0.73063940
97MP0001963_abnormal_hearing_physiology0.69433151
98MP0003828_pulmonary_edema0.66477816
99MP0005195_abnormal_posterior_eye0.65990126
100MP0002109_abnormal_limb_morphology0.65695568

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)6.54642863
2Premature loss of primary teeth (HP:0006323)5.88343386
3Persistence of primary teeth (HP:0006335)5.45148678
4Chronic hepatic failure (HP:0100626)4.10270188
5Limb dystonia (HP:0002451)3.87910750
6Abnormality of midbrain morphology (HP:0002418)3.72205734
7Molar tooth sign on MRI (HP:0002419)3.72205734
8Type II lissencephaly (HP:0007260)3.67756267
9Retinal dysplasia (HP:0007973)3.65837592
10Abnormality of polysaccharide metabolism (HP:0011012)3.56592249
11Abnormality of glycosaminoglycan metabolism (HP:0004371)3.56592249
12Abnormality of mucopolysaccharide metabolism (HP:0011020)3.56592249
13Decreased central vision (HP:0007663)3.48220337
14Urinary glycosaminoglycan excretion (HP:0003541)3.42226172
15Mucopolysacchariduria (HP:0008155)3.42226172
16Rhinitis (HP:0012384)3.39082922
17Lissencephaly (HP:0001339)3.37109025
18Broad-based gait (HP:0002136)3.33498884
19Asymmetric septal hypertrophy (HP:0001670)3.32768211
20Pancreatic fibrosis (HP:0100732)3.27876342
21Periodontitis (HP:0000704)3.24169690
22Cerebellar dysplasia (HP:0007033)3.09395204
23Abnormality of the labia minora (HP:0012880)3.07171369
24Pancreatic cysts (HP:0001737)2.96091634
25Infantile muscular hypotonia (HP:0008947)2.91711821
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.91536040
27Abnormality of primary teeth (HP:0006481)2.84672105
28Abnormality of incisor morphology (HP:0011063)2.83254996
29Rib fusion (HP:0000902)2.78710253
30Aplasia/Hypoplasia of the tibia (HP:0005772)2.76598035
31Attenuation of retinal blood vessels (HP:0007843)2.73452895
32True hermaphroditism (HP:0010459)2.72441938
33Nephronophthisis (HP:0000090)2.70871466
34Ovoid vertebral bodies (HP:0003300)2.68478836
35Abnormality of the renal cortex (HP:0011035)2.68208740
36Dysostosis multiplex (HP:0000943)2.68040401
37Abnormality of dental color (HP:0011073)2.66175463
38Acute lymphatic leukemia (HP:0006721)2.63914458
39Short tibia (HP:0005736)2.56813882
40Abnormality of the renal medulla (HP:0100957)2.53203275
41Loss of speech (HP:0002371)2.52140810
42Renal cortical cysts (HP:0000803)2.45951400
43Postaxial foot polydactyly (HP:0001830)2.42900349
44Malignant hyperthermia (HP:0002047)2.26540644
45Entropion (HP:0000621)2.24743727
46Hypokinesia (HP:0002375)2.20325142
47Abnormality of vision evoked potentials (HP:0000649)2.20195122
48Cone-rod dystrophy (HP:0000548)2.19629681
49Ulnar deviation of the wrist (HP:0003049)2.18428060
50Abnormality of DNA repair (HP:0003254)2.14301135
51Preaxial foot polydactyly (HP:0001841)2.12516855
52Vacuolated lymphocytes (HP:0001922)2.10474458
53Sensorimotor neuropathy (HP:0007141)2.08455300
54Hypokalemic alkalosis (HP:0001949)2.05322319
55Abnormality of the incisor (HP:0000676)2.03684099
56Abolished electroretinogram (ERG) (HP:0000550)2.00832313
57Atonic seizures (HP:0010819)1.98694895
58Rectovaginal fistula (HP:0000143)1.98325703
59Rectal fistula (HP:0100590)1.98325703
60Abnormality of the costochondral junction (HP:0000919)1.97893555
61Progressive cerebellar ataxia (HP:0002073)1.95820954
62Chronic sinusitis (HP:0011109)1.95356300
63Febrile seizures (HP:0002373)1.94581594
64Joint stiffness (HP:0001387)1.94297305
65Congenital sensorineural hearing impairment (HP:0008527)1.93927526
66Action tremor (HP:0002345)1.88960192
67Cervical subluxation (HP:0003308)1.88286036
68Postaxial hand polydactyly (HP:0001162)1.85340592
69Narrow forehead (HP:0000341)1.85339906
70Sclerocornea (HP:0000647)1.85289002
71Aplasia/Hypoplasia of the earlobes (HP:0009906)1.84674117
72Oligodontia (HP:0000677)1.84271200
73Recurrent bronchitis (HP:0002837)1.83983984
74Disproportionate short-trunk short stature (HP:0003521)1.82024202
75Abnormality of the metopic suture (HP:0005556)1.81869910
76Anophthalmia (HP:0000528)1.81833200
77Delusions (HP:0000746)1.81111723
78Metaphyseal dysplasia (HP:0100255)1.79443175
79Cystic liver disease (HP:0006706)1.79312668
80Spastic tetraplegia (HP:0002510)1.77743882
81Scotoma (HP:0000575)1.77149288
82Brittle hair (HP:0002299)1.76940917
83Hypsarrhythmia (HP:0002521)1.76916916
84EEG with generalized epileptiform discharges (HP:0011198)1.75043382
85Congenital stationary night blindness (HP:0007642)1.73477728
86Thyroiditis (HP:0100646)1.72780768
87Epileptiform EEG discharges (HP:0011182)1.72297950
88Vaginal fistula (HP:0004320)1.71301352
89Tachypnea (HP:0002789)1.69935872
90Flared iliac wings (HP:0002869)1.69882717
91Abnormal hair whorl (HP:0010721)1.68654196
923-Methylglutaconic aciduria (HP:0003535)1.67824773
93Gait imbalance (HP:0002141)1.66245522
94Intestinal fistula (HP:0100819)1.65983882
95Muscular hypotonia of the trunk (HP:0008936)1.64835659
96Generalized myoclonic seizures (HP:0002123)1.62604146
97Fair hair (HP:0002286)1.62406269
98Abnormality of the parathyroid morphology (HP:0011766)1.61980852
99Prominent metopic ridge (HP:0005487)1.61860612
100Clumsiness (HP:0002312)1.59918811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.49915995
2CDC42BPA4.61157354
3MAP4K24.27087608
4PINK13.73034565
5MAP3K133.02894264
6TNIK2.76518449
7CCNB12.48333926
8TESK22.45479938
9MAP2K22.45306553
10TLK12.44423879
11MAPKAPK52.33971698
12MARK11.83100949
13WNK31.77175802
14ACVR1B1.55769076
15MAP3K41.55079792
16CDK81.50819101
17NTRK31.49767197
18BCR1.47025320
19NTRK21.45939744
20ADRBK21.31461123
21GRK71.30311190
22CAMK2B1.29888824
23TAOK31.21351547
24EPHA31.21284349
25PAK31.17592975
26FRK1.16768344
27GRK11.15847410
28BMPR21.14635614
29CSNK1G31.10726134
30MAP2K11.10724594
31CSNK1G21.03382885
32TXK1.02109685
33MAP3K121.02041790
34MAP3K71.01276392
35TGFBR20.99599338
36WNK40.99303833
37CAMK1D0.99200435
38MKNK20.97923124
39CAMK1G0.95516621
40NUAK10.92567388
41PRKCG0.91780846
42MAP2K70.90414220
43CDK190.89854918
44CSNK1A1L0.88105951
45MELK0.87241967
46ADRBK10.84958835
47SIK20.83104207
48CAMKK20.83037361
49RPS6KA40.81753698
50PNCK0.79987343
51CSNK1G10.78785463
52MAPK130.78683969
53RPS6KA50.71270522
54SGK30.71211462
55TRIM280.70327853
56CAMK2D0.69941479
57CAMK2A0.68662249
58PRKACB0.66705960
59MAP3K140.66687509
60RIPK40.66668194
61MOS0.65846667
62GRK60.65709183
63STK380.65618533
64CAMK2G0.63923588
65PKN10.63250117
66CAMK40.62276746
67CDK11A0.61612817
68PHKG10.59505346
69PHKG20.59505346
70DYRK20.58344129
71MAPK150.57803261
72GRK50.57011486
73STK110.55862838
74HCK0.54876631
75NEK90.50694767
76CDK50.48240793
77INSRR0.47102545
78CDK180.44343855
79BMPR1B0.43955256
80CDK150.43748096
81OXSR10.42877599
82ALK0.41021562
83STK390.38340438
84CDK140.38142720
85MKNK10.37215213
86PRKCI0.34939220
87PRKD20.33134302
88EIF2AK30.31970517
89MAP2K40.31885363
90WNK10.31369003
91PRKDC0.30536460
92PRKACA0.29832411
93LCK0.28665635
94CASK0.28348088
95CAMK10.27473187
96OBSCN0.25965843
97EPHA40.25920732
98PRKCB0.25763889
99GSK3B0.24257727
100PRKACG0.23663187

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.51442991
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.04127711
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86163483
4Phenylalanine metabolism_Homo sapiens_hsa003602.83349221
5Caffeine metabolism_Homo sapiens_hsa002322.43775654
6Phototransduction_Homo sapiens_hsa047442.38191088
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07388671
8Cysteine and methionine metabolism_Homo sapiens_hsa002702.00083594
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa0040010.4916969
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92342205
11Tyrosine metabolism_Homo sapiens_hsa003501.80327505
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.63023271
13Tryptophan metabolism_Homo sapiens_hsa003801.51411034
14Steroid biosynthesis_Homo sapiens_hsa001001.49861625
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45675524
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34406646
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25253033
18Nicotine addiction_Homo sapiens_hsa050331.25083076
19Regulation of autophagy_Homo sapiens_hsa041401.24154009
20Fanconi anemia pathway_Homo sapiens_hsa034601.16258224
21ABC transporters_Homo sapiens_hsa020101.10816628
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09631890
23Basal transcription factors_Homo sapiens_hsa030221.04765588
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.00925139
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00921553
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95223796
27Nitrogen metabolism_Homo sapiens_hsa009100.92207973
28Taste transduction_Homo sapiens_hsa047420.91975363
29Dopaminergic synapse_Homo sapiens_hsa047280.90551255
30Intestinal immune network for IgA production_Homo sapiens_hsa046720.86230692
31Cocaine addiction_Homo sapiens_hsa050300.85877298
32Circadian rhythm_Homo sapiens_hsa047100.85632984
33Non-homologous end-joining_Homo sapiens_hsa034500.84218451
34Amphetamine addiction_Homo sapiens_hsa050310.80389682
35RNA degradation_Homo sapiens_hsa030180.77899134
36Morphine addiction_Homo sapiens_hsa050320.77643258
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74326555
38Butanoate metabolism_Homo sapiens_hsa006500.70468133
39Vitamin B6 metabolism_Homo sapiens_hsa007500.70374225
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69973254
41GABAergic synapse_Homo sapiens_hsa047270.69949408
42mRNA surveillance pathway_Homo sapiens_hsa030150.59360154
43Salivary secretion_Homo sapiens_hsa049700.59039756
44Peroxisome_Homo sapiens_hsa041460.57809754
45Collecting duct acid secretion_Homo sapiens_hsa049660.56953017
46Circadian entrainment_Homo sapiens_hsa047130.56265560
47Insulin secretion_Homo sapiens_hsa049110.56191640
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55761604
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54698215
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53154089
51Serotonergic synapse_Homo sapiens_hsa047260.50939823
52Rheumatoid arthritis_Homo sapiens_hsa053230.49877632
53Olfactory transduction_Homo sapiens_hsa047400.48674463
54Sphingolipid metabolism_Homo sapiens_hsa006000.46792087
55Nucleotide excision repair_Homo sapiens_hsa034200.43982987
56Cholinergic synapse_Homo sapiens_hsa047250.43322590
57Purine metabolism_Homo sapiens_hsa002300.40364244
58Renin secretion_Homo sapiens_hsa049240.39609434
59One carbon pool by folate_Homo sapiens_hsa006700.38083197
60Chemical carcinogenesis_Homo sapiens_hsa052040.37338352
61Base excision repair_Homo sapiens_hsa034100.36878766
62Glutamatergic synapse_Homo sapiens_hsa047240.35575557
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30669588
64Prolactin signaling pathway_Homo sapiens_hsa049170.28495668
65Linoleic acid metabolism_Homo sapiens_hsa005910.27868261
66Osteoclast differentiation_Homo sapiens_hsa043800.26747194
67Calcium signaling pathway_Homo sapiens_hsa040200.26516920
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24896785
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.24337848
70Homologous recombination_Homo sapiens_hsa034400.24337133
71Glucagon signaling pathway_Homo sapiens_hsa049220.23986010
72Lysine degradation_Homo sapiens_hsa003100.23781962
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23185511
74Arginine biosynthesis_Homo sapiens_hsa002200.22177410
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20959285
76Retinol metabolism_Homo sapiens_hsa008300.19786941
77Hematopoietic cell lineage_Homo sapiens_hsa046400.18912853
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18372716
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17394165
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16419366
81MAPK signaling pathway_Homo sapiens_hsa040100.15158646
82Arachidonic acid metabolism_Homo sapiens_hsa005900.15018166
83Metabolic pathways_Homo sapiens_hsa011000.14499175
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14488236
85Pentose phosphate pathway_Homo sapiens_hsa000300.14173780
86Biosynthesis of amino acids_Homo sapiens_hsa012300.14064939
87RNA polymerase_Homo sapiens_hsa030200.13295652
88Propanoate metabolism_Homo sapiens_hsa006400.12456022
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12314186
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.11738697
91Legionellosis_Homo sapiens_hsa051340.11509728
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10870877
93Lysosome_Homo sapiens_hsa041420.10667031
94RNA transport_Homo sapiens_hsa030130.09950519
95Oxidative phosphorylation_Homo sapiens_hsa001900.09789238
96Alcoholism_Homo sapiens_hsa050340.09727552
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.09484547
98Cardiac muscle contraction_Homo sapiens_hsa042600.09472279
99Long-term depression_Homo sapiens_hsa047300.09283251
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.07426494

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