ENSA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.04959932
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.87490455
3synaptic vesicle exocytosis (GO:0016079)5.73743763
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.43058073
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38615917
6vocalization behavior (GO:0071625)5.35560386
7viral transcription (GO:0019083)5.26497685
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.25577770
9glutamate secretion (GO:0014047)5.21933905
10synaptic vesicle maturation (GO:0016188)5.16820435
11regulation of synaptic vesicle exocytosis (GO:2000300)5.13973970
12regulation of glutamate receptor signaling pathway (GO:1900449)5.05053101
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.89185721
14translational termination (GO:0006415)4.88786499
15protein localization to synapse (GO:0035418)4.83244543
16locomotory exploration behavior (GO:0035641)4.83236446
17regulation of synaptic vesicle transport (GO:1902803)4.66704719
18maturation of SSU-rRNA (GO:0030490)4.63801849
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.61845752
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56578847
21neuronal action potential propagation (GO:0019227)4.46903195
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.42332036
23translational elongation (GO:0006414)4.35365798
24neuron cell-cell adhesion (GO:0007158)4.21598719
25glutamate receptor signaling pathway (GO:0007215)4.20860563
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.20268378
27neurotransmitter-gated ion channel clustering (GO:0072578)4.18017804
28neurotransmitter secretion (GO:0007269)4.16873905
29regulation of neuronal synaptic plasticity (GO:0048168)4.14972790
30synaptic transmission, glutamatergic (GO:0035249)4.14710596
31neuron-neuron synaptic transmission (GO:0007270)4.11200102
32ribosomal small subunit assembly (GO:0000028)4.09719738
33viral life cycle (GO:0019058)4.05087060
34exploration behavior (GO:0035640)3.99615901
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98966205
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.97457191
37cellular protein complex disassembly (GO:0043624)3.97317780
38spliceosomal tri-snRNP complex assembly (GO:0000244)3.94166359
39regulation of synapse structural plasticity (GO:0051823)3.90958734
40positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.90602985
41protein targeting to ER (GO:0045047)3.90064298
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.89386372
43long-term synaptic potentiation (GO:0060291)3.86197333
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.85760151
45cotranslational protein targeting to membrane (GO:0006613)3.81715386
46positive regulation of synapse maturation (GO:0090129)3.80237899
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.79239051
48protein complex disassembly (GO:0043241)3.75930169
49regulation of postsynaptic membrane potential (GO:0060078)3.74787404
50NADH metabolic process (GO:0006734)3.73931223
51regulation of mammary gland epithelial cell proliferation (GO:0033599)3.71511268
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68214066
53protein localization to endoplasmic reticulum (GO:0070972)3.67039223
54regulation of translational fidelity (GO:0006450)3.66423646
55regulation of synaptic plasticity (GO:0048167)3.66241394
56synaptic vesicle endocytosis (GO:0048488)3.65078697
57positive regulation of membrane potential (GO:0045838)3.62269584
58positive regulation of neurotransmitter secretion (GO:0001956)3.61062939
59translational initiation (GO:0006413)3.59231513
60long-term memory (GO:0007616)3.51274308
61macromolecular complex disassembly (GO:0032984)3.50286603
62regulation of neurotransmitter secretion (GO:0046928)3.50006617
63neuron recognition (GO:0008038)3.49405916
64presynaptic membrane assembly (GO:0097105)3.47637142
65proline transport (GO:0015824)3.46025241
66postsynaptic membrane organization (GO:0001941)3.43517813
67maternal placenta development (GO:0001893)3.39700075
68positive regulation of neurotransmitter transport (GO:0051590)3.39517809
69response to histamine (GO:0034776)3.39022681
70regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3.38721045
71positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling3.38721045
72cellular potassium ion homeostasis (GO:0030007)3.38720980
73regulation of glutamate secretion (GO:0014048)3.38619760
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.38368575
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.38331567
76activation of protein kinase A activity (GO:0034199)3.38047057
77regulation of dendritic spine morphogenesis (GO:0061001)3.36448054
78regulation of vesicle fusion (GO:0031338)3.35464380
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.33865679
80neurotransmitter transport (GO:0006836)3.31858673
81COPI coating of Golgi vesicle (GO:0048205)3.31602385
82Golgi transport vesicle coating (GO:0048200)3.31602385
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30039100
84presynaptic membrane organization (GO:0097090)3.29871453
85negative regulation of dendrite morphogenesis (GO:0050774)3.29804604
86DNA unwinding involved in DNA replication (GO:0006268)3.28164558
87protein complex localization (GO:0031503)3.24982469
88membrane depolarization (GO:0051899)3.23590057
89negative regulation of microtubule polymerization (GO:0031115)3.23407997
90regulation of water loss via skin (GO:0033561)3.22701332
91axonal fasciculation (GO:0007413)3.22192512
92behavioral defense response (GO:0002209)3.22023151
93behavioral fear response (GO:0001662)3.22023151
94layer formation in cerebral cortex (GO:0021819)3.19576668
95regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18371904
96regulation of neurotransmitter transport (GO:0051588)3.18029985
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17517040
98regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.15678681
99regulation of voltage-gated calcium channel activity (GO:1901385)3.15416966
100sodium ion export (GO:0071436)3.15381215
101vesicle transport along microtubule (GO:0047496)3.15341410
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15126684
103membrane depolarization during action potential (GO:0086010)3.14857689
104dendritic spine morphogenesis (GO:0060997)3.13258224
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13252306
106regulation of chromatin binding (GO:0035561)3.09347584
107cerebellar granule cell differentiation (GO:0021707)3.08655878
108positive regulation of synaptic transmission (GO:0050806)3.08481546
109proline biosynthetic process (GO:0006561)3.08167174
110energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.07311423
111ATP hydrolysis coupled proton transport (GO:0015991)3.07311423
112regulation of neurotransmitter levels (GO:0001505)3.07232680
113transferrin transport (GO:0033572)3.07204210
114protein targeting to membrane (GO:0006612)3.05233276
115fear response (GO:0042596)3.04442472
116negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03235187
117negative regulation of dendrite development (GO:2000171)3.02983043
118cerebellar Purkinje cell differentiation (GO:0021702)3.02649745
119peptidyl-arginine omega-N-methylation (GO:0035247)3.01828586
120ribonucleoprotein complex biogenesis (GO:0022613)3.01543689
121regulation of synapse maturation (GO:0090128)3.00844940
122negative regulation of amino acid transport (GO:0051956)3.00557858
123regulation of synaptic transmission (GO:0050804)2.99216496
124detection of calcium ion (GO:0005513)2.99211730
125regulation of dendritic spine development (GO:0060998)2.99126690
126positive regulation of keratinocyte differentiation (GO:0045618)2.98240181
127positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97650128
128nucleobase-containing small molecule interconversion (GO:0015949)2.97231391
129synaptic transmission (GO:0007268)2.96920013
130mitotic chromosome condensation (GO:0007076)2.96013154
131gamma-aminobutyric acid transport (GO:0015812)2.95938888
132learning (GO:0007612)2.95121405
133behavioral response to cocaine (GO:0048148)2.94685775
134positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92238823
135transmission of nerve impulse (GO:0019226)2.90139850
136innervation (GO:0060384)2.89430350
137neuromuscular process controlling balance (GO:0050885)2.85374828
138synaptic vesicle transport (GO:0048489)2.85145176
139establishment of synaptic vesicle localization (GO:0097480)2.85145176
140long term synaptic depression (GO:0060292)2.84620719
141ferric iron transport (GO:0015682)2.83838686
142trivalent inorganic cation transport (GO:0072512)2.83838686
143regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.83806768
144positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.83587153
145ear development (GO:0043583)2.82468763
146protein retention in ER lumen (GO:0006621)2.79967661
147mitochondrial fusion (GO:0008053)2.78986502
148adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.75139285
149focal adhesion assembly (GO:0048041)2.74230697
150cell-substrate adherens junction assembly (GO:0007045)2.74230697
151regulation of glucose import in response to insulin stimulus (GO:2001273)2.72816174
152cellular protein complex localization (GO:0034629)2.72202352
153negative regulation of cell size (GO:0045792)2.70924708
154dopamine receptor signaling pathway (GO:0007212)2.69280926
155response to parathyroid hormone (GO:0071107)2.68360115
156adherens junction assembly (GO:0034333)2.67473399
157nucleosome disassembly (GO:0006337)2.67398543
158protein-DNA complex disassembly (GO:0032986)2.67398543
159formation of translation preinitiation complex (GO:0001731)2.66652667
1603-UTR-mediated mRNA stabilization (GO:0070935)2.65656242
161regulation of early endosome to late endosome transport (GO:2000641)2.62234257
162adenine nucleotide transport (GO:0051503)2.61716628
163histone arginine methylation (GO:0034969)2.61074527
164negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.59322494
165negative regulation of organelle assembly (GO:1902116)2.58694139
166nuclear-transcribed mRNA catabolic process (GO:0000956)2.57793408
167UTP metabolic process (GO:0046051)2.56782133
168establishment of protein localization to membrane (GO:0090150)2.55082518
169mitotic G1 DNA damage checkpoint (GO:0031571)2.54702074
170cytoskeletal anchoring at plasma membrane (GO:0007016)2.52079707
171RNA stabilization (GO:0043489)2.51700502
172mRNA stabilization (GO:0048255)2.51700502
173pentose-phosphate shunt (GO:0006098)2.50979032
174maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49696815
175mRNA catabolic process (GO:0006402)2.48551069
176translation (GO:0006412)2.48077980
177intracellular estrogen receptor signaling pathway (GO:0030520)2.47417897
178activation of Rac GTPase activity (GO:0032863)2.47008903
179nuclear envelope reassembly (GO:0031468)2.46563235
180mitotic nuclear envelope reassembly (GO:0007084)2.46563235
181purine nucleotide transport (GO:0015865)2.45730345
182trophectodermal cell differentiation (GO:0001829)2.45510290
183epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45253998
184multicellular organismal water homeostasis (GO:0050891)2.45072042
185positive regulation of mitochondrion organization (GO:0010822)2.43547995
186G1 DNA damage checkpoint (GO:0044783)2.41605691
187establishment of skin barrier (GO:0061436)2.41018678
188gluconeogenesis (GO:0006094)2.40614956
189protein insertion into membrane (GO:0051205)2.39944937
190monosaccharide biosynthetic process (GO:0046364)2.39358836
191UTP biosynthetic process (GO:0006228)2.38285317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.08021821
2GBX2_23144817_ChIP-Seq_PC3_Human3.98929580
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.46405384
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.31500304
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.19273377
6E2F7_22180533_ChIP-Seq_HELA_Human3.09819265
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04891346
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80602439
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80417661
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.75155230
11REST_21632747_ChIP-Seq_MESCs_Mouse2.74245301
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73118326
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73118326
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.70556101
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63390917
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60929300
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59177010
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51315713
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50637958
20ZNF263_19887448_ChIP-Seq_K562_Human2.44634647
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.43019326
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.40722401
23DROSHA_22980978_ChIP-Seq_HELA_Human2.36686493
24RACK7_27058665_Chip-Seq_MCF-7_Human2.35081371
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.30698579
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.30617846
27MYC_22102868_ChIP-Seq_BL_Human2.30088466
28* XRN2_22483619_ChIP-Seq_HELA_Human2.25018605
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21249810
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17231461
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16275936
32LXR_22292898_ChIP-Seq_THP-1_Human2.15091784
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.13665629
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.13485450
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11042307
36TAF15_26573619_Chip-Seq_HEK293_Human2.09719780
37ESR2_21235772_ChIP-Seq_MCF-7_Human2.07991806
38* VDR_21846776_ChIP-Seq_THP-1_Human2.06581953
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04365228
40MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01207037
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01018607
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99072608
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96662410
44* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.94018658
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87740566
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87137347
47AR_21572438_ChIP-Seq_LNCaP_Human1.84992050
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.83767418
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.81738921
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.81253783
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80800996
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75974186
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73467176
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72316245
55* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68063253
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.67951840
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64495718
58* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64049228
59P300_19829295_ChIP-Seq_ESCs_Human1.63836770
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.63627219
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62464540
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.61865776
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60376112
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59100173
65P68_20966046_ChIP-Seq_HELA_Human1.57765026
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.56806794
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56019706
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53658427
69* CREB1_26743006_Chip-Seq_LNCaP_Human1.53044372
70* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51934923
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51283157
72* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50928649
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49153541
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48554478
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47056106
76KDM2B_26808549_Chip-Seq_DND41_Human1.45893660
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44689495
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43812559
79KDM2B_26808549_Chip-Seq_K562_Human1.42925847
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.42386767
81KDM5A_27292631_Chip-Seq_BREAST_Human1.42347321
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42201247
83TCF7_22412390_ChIP-Seq_EML_Mouse1.41834547
84ZNF274_21170338_ChIP-Seq_K562_Hela1.41759272
85SMC4_20622854_ChIP-Seq_HELA_Human1.40838759
86AR_25329375_ChIP-Seq_VCAP_Human1.40589030
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40269681
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.39403533
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39124283
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38692628
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.35397459
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.35321445
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35077743
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34938707
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34155342
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.34004799
97* SA1_27219007_Chip-Seq_ERYTHROID_Human1.32655492
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.32553512
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32463769
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.31124068
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30780936
102* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30170735
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.29453930
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27914467
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27564977
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.26968903
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26955306
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25714977
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25453637
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24768696
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24346374
112* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23241092
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22836908
114IGF1R_20145208_ChIP-Seq_DFB_Human1.22770137
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22476553
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22150948
117CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22087504
118* CHD1_26751641_Chip-Seq_LNCaP_Human1.21440369
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20454212
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20128732
121* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19903095
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18794562
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18666277
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18563051
125AR_19668381_ChIP-Seq_PC3_Human1.18232206
126* TTF2_22483619_ChIP-Seq_HELA_Human1.18011867
127STAT3_23295773_ChIP-Seq_U87_Human1.17628176
128* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17542006
129DCP1A_22483619_ChIP-Seq_HELA_Human1.17356642
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.17173465
131* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16954668
132OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16494758
133SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14730717
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.14256680
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13874293
136* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13474288
137CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12697472
138CBX2_27304074_Chip-Seq_ESCs_Mouse1.12458173
139FUS_26573619_Chip-Seq_HEK293_Human1.11998977
140* PRDM14_20953172_ChIP-Seq_ESCs_Human1.11545398
141KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11477751
142TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11115144
143TCF4_23295773_ChIP-Seq_U87_Human1.10064034
144EGR1_19374776_ChIP-ChIP_THP-1_Human1.09820214
145ARNT_22903824_ChIP-Seq_MCF-7_Human1.09636645
146TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09535387
147* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09479319
148MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09147698
149P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08860169
150KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08631489
151CIITA_25753668_ChIP-Seq_RAJI_Human1.08309803
152* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07104734
153* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06322283
154SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06264453
155CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06256199
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05106119
157CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04619808
158VDR_22108803_ChIP-Seq_LS180_Human1.04590169
159VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04306160
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03618758
161KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03266850
162RNF2_27304074_Chip-Seq_NSC_Mouse1.03059874
163RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03005899
164TP53_18474530_ChIP-ChIP_U2OS_Human1.02860113
165YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02844426
166SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02697315
167JUN_21703547_ChIP-Seq_K562_Human1.02653552
168* SA1_27219007_Chip-Seq_Bcells_Human1.02012736
169ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01843314
170CLOCK_20551151_ChIP-Seq_293T_Human1.00986752
171FOXP1_21924763_ChIP-Seq_HESCs_Human1.00930853
172AHR_22903824_ChIP-Seq_MCF-7_Human0.99819358
173TP53_16413492_ChIP-PET_HCT116_Human0.98728933
174MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97637052
175ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96882272
176EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96553459
177RUNX2_22187159_ChIP-Seq_PCA_Human0.96247163
178ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96194707
179* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93774157
180SMAD3_21741376_ChIP-Seq_ESCs_Human0.92317617
181MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91351644
182RXR_22108803_ChIP-Seq_LS180_Human0.91039076
183* ER_23166858_ChIP-Seq_MCF-7_Human0.90593696
184AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90592647
185BCAT_22108803_ChIP-Seq_LS180_Human0.90044361
186RING1B_27294783_Chip-Seq_NPCs_Mouse0.88945837
187CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88589758
188RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86496720
189GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85885386
190NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85237439
191TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83888929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.47058925
2MP0003880_abnormal_central_pattern5.51863526
3MP0009379_abnormal_foot_pigmentation4.61104968
4MP0003635_abnormal_synaptic_transmissio4.17853159
5MP0009745_abnormal_behavioral_response3.50061459
6MP0002796_impaired_skin_barrier3.47352958
7MP0002063_abnormal_learning/memory/cond3.41587874
8MP0004270_analgesia3.40781831
9MP0001968_abnormal_touch/_nociception3.37684206
10MP0002064_seizures3.26805898
11MP0009046_muscle_twitch3.13180894
12MP0002736_abnormal_nociception_after2.94421208
13MP0004185_abnormal_adipocyte_glucose2.85082053
14MP0002572_abnormal_emotion/affect_behav2.83162769
15MP0002272_abnormal_nervous_system2.51061503
16MP0003693_abnormal_embryo_hatching2.47964509
17MP0002734_abnormal_mechanical_nocicepti2.44160166
18MP0001501_abnormal_sleep_pattern2.42446185
19MP0002735_abnormal_chemical_nociception2.42153336
20MP0002822_catalepsy2.31262953
21MP0001440_abnormal_grooming_behavior2.25179913
22MP0005501_abnormal_skin_physiology2.20397550
23MP0001486_abnormal_startle_reflex2.19734549
24MP0005423_abnormal_somatic_nervous2.17158695
25MP0001346_abnormal_lacrimal_gland2.02864581
26MP0002067_abnormal_sensory_capabilities2.02487899
27MP0003705_abnormal_hypodermis_morpholog1.98311819
28MP0009672_abnormal_birth_weight1.96349432
29MP0002733_abnormal_thermal_nociception1.96015733
30MP0002877_abnormal_melanocyte_morpholog1.95043580
31MP0001970_abnormal_pain_threshold1.92278604
32MP0005451_abnormal_body_composition1.92270194
33MP0005076_abnormal_cell_differentiation1.91029827
34MP0003787_abnormal_imprinting1.90074872
35MP0002837_dystrophic_cardiac_calcinosis1.89756399
36MP0004264_abnormal_extraembryonic_tissu1.83952681
37MP0000751_myopathy1.80980653
38MP0003329_amyloid_beta_deposits1.78908604
39MP0008569_lethality_at_weaning1.76215881
40MP0006276_abnormal_autonomic_nervous1.74029419
41MP0004858_abnormal_nervous_system1.73120641
42MP0004924_abnormal_behavior1.73022509
43MP0005386_behavior/neurological_phenoty1.73022509
44MP0004811_abnormal_neuron_physiology1.72717259
45MP0003879_abnormal_hair_cell1.69282185
46MP0009780_abnormal_chondrocyte_physiolo1.68766357
47MP0002184_abnormal_innervation1.66739412
48MP0004957_abnormal_blastocyst_morpholog1.65516303
49MP0003111_abnormal_nucleus_morphology1.63853798
50MP0002557_abnormal_social/conspecific_i1.58269238
51MP0000778_abnormal_nervous_system1.56791565
52MP0000678_abnormal_parathyroid_gland1.53863173
53MP0002909_abnormal_adrenal_gland1.51254251
54MP0000750_abnormal_muscle_regeneration1.50558561
55MP0000579_abnormal_nail_morphology1.49601697
56MP0003122_maternal_imprinting1.45394670
57MP0005646_abnormal_pituitary_gland1.44396619
58MP0001984_abnormal_olfaction1.43629769
59MP0000566_synostosis1.36467422
60MP0005666_abnormal_adipose_tissue1.36281536
61MP0002066_abnormal_motor_capabilities/c1.34575273
62MP0003633_abnormal_nervous_system1.30871179
63MP0001730_embryonic_growth_arrest1.30627737
64MP0002098_abnormal_vibrissa_morphology1.29805813
65MP0000955_abnormal_spinal_cord1.29723170
66MP0003941_abnormal_skin_development1.29255212
67MP0001905_abnormal_dopamine_level1.28696774
68MP0002882_abnormal_neuron_morphology1.27722313
69MP0004145_abnormal_muscle_electrophysio1.26869557
70MP0005058_abnormal_lysosome_morphology1.24592324
71MP0001529_abnormal_vocalization1.23283862
72MP0010094_abnormal_chromosome_stability1.22844963
73MP0006036_abnormal_mitochondrial_physio1.21939571
74MP0000350_abnormal_cell_proliferation1.21729002
75MP0001502_abnormal_circadian_rhythm1.21659232
76MP0004782_abnormal_surfactant_physiolog1.17948685
77MP0000013_abnormal_adipose_tissue1.16905063
78MP0002249_abnormal_larynx_morphology1.16493267
79MP0001188_hyperpigmentation1.15439134
80MP0003077_abnormal_cell_cycle1.14742720
81MP0004087_abnormal_muscle_fiber1.13993070
82MP0001727_abnormal_embryo_implantation1.11140582
83MP0003453_abnormal_keratinocyte_physiol1.10770194
84MP0004215_abnormal_myocardial_fiber1.10647636
85MP0001881_abnormal_mammary_gland1.09954582
86MP0000627_abnormal_mammary_gland1.09029901
87MP0010386_abnormal_urinary_bladder1.08231954
88MP0003631_nervous_system_phenotype1.08037385
89MP0004233_abnormal_muscle_weight1.07577601
90MP0004142_abnormal_muscle_tone1.06226450
91MP0004484_altered_response_of1.06101886
92MP0003646_muscle_fatigue1.06046562
93MP0002080_prenatal_lethality1.03682997
94MP0005645_abnormal_hypothalamus_physiol1.02460750
95MP0000537_abnormal_urethra_morphology1.01329660
96MP0008874_decreased_physiological_sensi0.98212418
97MP0004510_myositis0.97996079
98MP0008932_abnormal_embryonic_tissue0.96618139
99MP0002089_abnormal_postnatal_growth/wei0.96359367
100MP0008872_abnormal_physiological_respon0.96329357
101MP0003938_abnormal_ear_development0.96071720
102MP0005083_abnormal_biliary_tract0.94817621
103MP0004885_abnormal_endolymph0.94505182
104MP0000604_amyloidosis0.94186529
105MP0000377_abnormal_hair_follicle0.94118952
106MP0001849_ear_inflammation0.92167956
107MP0002152_abnormal_brain_morphology0.92084672
108MP0000733_abnormal_muscle_development0.88200590
109MP0006035_abnormal_mitochondrial_morpho0.86532547
110MP0004085_abnormal_heartbeat0.86089155
111MP0002876_abnormal_thyroid_physiology0.85820127
112MP0003075_altered_response_to0.85706882
113MP0005375_adipose_tissue_phenotype0.85233562
114MP0010630_abnormal_cardiac_muscle0.84875770
115MP0000681_abnormal_thyroid_gland0.84700708
116MP0005380_embryogenesis_phenotype0.83921865
117MP0001672_abnormal_embryogenesis/_devel0.83921865
118MP0004036_abnormal_muscle_relaxation0.83513122
119MP0001697_abnormal_embryo_size0.82967971
120MP0010234_abnormal_vibrissa_follicle0.82308624
121MP0002069_abnormal_eating/drinking_beha0.82196590
122MP0001348_abnormal_lacrimal_gland0.81874360
123MP0002229_neurodegeneration0.81006057
124MP0000462_abnormal_digestive_system0.79779357
125MP0008007_abnormal_cellular_replicative0.79693904
126MP0002269_muscular_atrophy0.78249697
127MP0005551_abnormal_eye_electrophysiolog0.78043944
128MP0005535_abnormal_body_temperature0.77017753
129MP0003984_embryonic_growth_retardation0.76876501
130MP0010678_abnormal_skin_adnexa0.76649891
131MP0001919_abnormal_reproductive_system0.76523140
132MP0004130_abnormal_muscle_cell0.75446975
133MP0002085_abnormal_embryonic_tissue0.74646468
134MP0000569_abnormal_digit_pigmentation0.74433930
135MP0004381_abnormal_hair_follicle0.74178377
136MP0002088_abnormal_embryonic_growth/wei0.74157139
137MP0000749_muscle_degeneration0.74154518
138MP0001177_atelectasis0.73558969
139MP0010771_integument_phenotype0.72802905
140MP0009703_decreased_birth_body0.71758290
141MP0000313_abnormal_cell_death0.71547092
142MP0004147_increased_porphyrin_level0.71446442
143MP0009931_abnormal_skin_appearance0.70395890
144MP0002090_abnormal_vision0.69671410
145MP0005409_darkened_coat_color0.69284148
146MP0001963_abnormal_hearing_physiology0.69188489
147MP0005623_abnormal_meninges_morphology0.67730565
148MP0005620_abnormal_muscle_contractility0.67245062
149MP0004742_abnormal_vestibular_system0.67023534
150MP0000747_muscle_weakness0.64674584
151MP0008961_abnormal_basal_metabolism0.64409699
152MP0003634_abnormal_glial_cell0.64052281
153MP0003632_abnormal_nervous_system0.64008473
154MP0001944_abnormal_pancreas_morphology0.63753836
155MP0000490_abnormal_crypts_of0.62915630
156MP0003861_abnormal_nervous_system0.62458879
157MP0003183_abnormal_peptide_metabolism0.61646437
158MP0001664_abnormal_digestion0.61480939
159MP0005499_abnormal_olfactory_system0.58973788
160MP0005394_taste/olfaction_phenotype0.58973788
161MP0001943_abnormal_respiration0.58312632
162MP0002752_abnormal_somatic_nervous0.56275879
163MP0003137_abnormal_impulse_conducting0.55733902
164MP0005167_abnormal_blood-brain_barrier0.55341858
165MP0000759_abnormal_skeletal_muscle0.51640570
166MP0003690_abnormal_glial_cell0.51111394
167MP0002106_abnormal_muscle_physiology0.50136339
168MP0003123_paternal_imprinting0.49552510
169MP0002972_abnormal_cardiac_muscle0.47927382

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.21778450
2Myokymia (HP:0002411)5.97272762
3Focal seizures (HP:0007359)5.78406309
4Epileptic encephalopathy (HP:0200134)5.33938845
5Visual hallucinations (HP:0002367)5.31396230
6Atonic seizures (HP:0010819)5.26164590
7Febrile seizures (HP:0002373)4.87609447
8Absence seizures (HP:0002121)4.57142153
9Dialeptic seizures (HP:0011146)4.13062915
10Hyperventilation (HP:0002883)4.08001670
11Generalized tonic-clonic seizures (HP:0002069)3.88465337
12Progressive muscle weakness (HP:0003323)3.79774962
13Hyperacusis (HP:0010780)3.73786673
14Progressive cerebellar ataxia (HP:0002073)3.69226559
15Distal lower limb muscle weakness (HP:0009053)3.68171934
16Broad-based gait (HP:0002136)3.60684993
17Amblyopia (HP:0000646)3.46339713
18Centrally nucleated skeletal muscle fibers (HP:0003687)3.43596128
19Poor eye contact (HP:0000817)3.32001638
20Impaired vibration sensation in the lower limbs (HP:0002166)3.31411847
21Abnormality of cells of the erythroid lineage (HP:0012130)3.30236664
22Depression (HP:0000716)3.10707813
23Myopathic facies (HP:0002058)3.08208046
24Action tremor (HP:0002345)3.07154800
25Asymmetry of the thorax (HP:0001555)3.06677725
26Septate vagina (HP:0001153)2.99247837
27Ankle clonus (HP:0011448)2.98575542
28Insomnia (HP:0100785)2.98251673
29Anxiety (HP:0000739)2.96040237
30Abnormal social behavior (HP:0012433)2.95507307
31Impaired social interactions (HP:0000735)2.95507307
32Abnormality of the lower motor neuron (HP:0002366)2.95233449
33Truncal ataxia (HP:0002078)2.95052721
34Pheochromocytoma (HP:0002666)2.94953894
35Hyperparathyroidism (HP:0000843)2.94144090
36Gaze-evoked nystagmus (HP:0000640)2.89864569
37Supranuclear gaze palsy (HP:0000605)2.87644716
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.81688251
39Abnormal eating behavior (HP:0100738)2.80890024
40Urinary bladder sphincter dysfunction (HP:0002839)2.78262060
41Distal lower limb amyotrophy (HP:0008944)2.76303141
42Abnormal number of erythroid precursors (HP:0012131)2.74579034
43Neuroendocrine neoplasm (HP:0100634)2.70885452
44Progressive inability to walk (HP:0002505)2.64741685
45Dysdiadochokinesis (HP:0002075)2.61757622
46Reticulocytopenia (HP:0001896)2.61347813
47Excessive salivation (HP:0003781)2.60664142
48Drooling (HP:0002307)2.60664142
49Ragged-red muscle fibers (HP:0003200)2.55008007
50Exercise-induced myalgia (HP:0003738)2.48089856
51Urinary urgency (HP:0000012)2.47668517
52Shoulder girdle muscle weakness (HP:0003547)2.46931858
53Dysmetria (HP:0001310)2.46913727
54Dysmetric saccades (HP:0000641)2.46443228
55Diplopia (HP:0000651)2.45552625
56Abnormality of binocular vision (HP:0011514)2.45552625
57Overriding aorta (HP:0002623)2.43690488
58Epileptiform EEG discharges (HP:0011182)2.43583074
59Muscle fiber inclusion bodies (HP:0100299)2.40745742
60Fetal akinesia sequence (HP:0001989)2.40372794
61EMG: neuropathic changes (HP:0003445)2.40027785
62Abnormality of the salivary glands (HP:0010286)2.39049169
63Achilles tendon contracture (HP:0001771)2.38867653
64Nemaline bodies (HP:0003798)2.38516043
65Bowel incontinence (HP:0002607)2.35593868
66Insidious onset (HP:0003587)2.35212785
67Termporal pattern (HP:0011008)2.35212785
68Obstructive sleep apnea (HP:0002870)2.34882426
69Abnormal hair whorl (HP:0010721)2.34620251
70Impaired smooth pursuit (HP:0007772)2.34174790
71Stereotypic behavior (HP:0000733)2.33850918
72Inability to walk (HP:0002540)2.33216753
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33069961
74Macrocytic anemia (HP:0001972)2.32170986
75Broad distal phalanx of finger (HP:0009836)2.30724192
76Multiple enchondromatosis (HP:0005701)2.30581349
77Progressive external ophthalmoplegia (HP:0000590)2.29794112
78Foot dorsiflexor weakness (HP:0009027)2.29676765
79Gout (HP:0001997)2.29654086
80Spinal cord compression (HP:0002176)2.28491966
81Postural instability (HP:0002172)2.28296178
82J-shaped sella turcica (HP:0002680)2.24795027
83Abnormal large intestine physiology (HP:0012700)2.24370597
84Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.23383393
85Failure to thrive in infancy (HP:0001531)2.23110518
86Germ cell neoplasia (HP:0100728)2.21078256
87Cerebral inclusion bodies (HP:0100314)2.19123710
88Cerebral hypomyelination (HP:0006808)2.18693055
89Bradykinesia (HP:0002067)2.16386920
90Polyphagia (HP:0002591)2.16349369
91Neuronal loss in central nervous system (HP:0002529)2.16263133
92Hyporeflexia of lower limbs (HP:0002600)2.14766735
93EEG with generalized epileptiform discharges (HP:0011198)2.14686384
94Abnormality of reticulocytes (HP:0004312)2.14616082
95Protruding tongue (HP:0010808)2.14352628
96Pseudobulbar signs (HP:0002200)2.14269797
97Resting tremor (HP:0002322)2.13902668
98Impaired vibratory sensation (HP:0002495)2.12367753
99Genetic anticipation (HP:0003743)2.09691808
100Hypercortisolism (HP:0001578)2.09083708
101Neoplasm of the peripheral nervous system (HP:0100007)2.08764373
102Mutism (HP:0002300)2.08448415
103Lower limb amyotrophy (HP:0007210)2.07878056
104Hypoventilation (HP:0002791)2.07418074
105Bundle branch block (HP:0011710)2.06492192
106Abnormality of the foot musculature (HP:0001436)2.06189528
107Deep palmar crease (HP:0006191)2.06100624
108Absent speech (HP:0001344)2.05095570
109Oligomenorrhea (HP:0000876)2.03225479
110Incomplete penetrance (HP:0003829)2.02192413
111Myotonia (HP:0002486)2.00377054
112EMG: myopathic abnormalities (HP:0003458)1.99540522
113Abnormality of ocular smooth pursuit (HP:0000617)1.99427055
114Abnormality of the Achilles tendon (HP:0005109)1.99364135
115Lower limb muscle weakness (HP:0007340)1.98770115
116Elfin facies (HP:0004428)1.97414092
117Spastic gait (HP:0002064)1.96813565
118Abnormality of nail color (HP:0100643)1.96715362
119Hypsarrhythmia (HP:0002521)1.96526002
120Psychosis (HP:0000709)1.95905072
121Torticollis (HP:0000473)1.95338970
122Scanning speech (HP:0002168)1.94482420
123Increased intramyocellular lipid droplets (HP:0012240)1.94408567
124Back pain (HP:0003418)1.94212706
125Pili torti (HP:0003777)1.93553136
126Delusions (HP:0000746)1.93373109
127Focal dystonia (HP:0004373)1.93360611
128Rapidly progressive (HP:0003678)1.93289976
129Papilledema (HP:0001085)1.93057394
130Reticulocytosis (HP:0001923)1.92479999
131Increased muscle lipid content (HP:0009058)1.92155914
132Overlapping toe (HP:0001845)1.91815513
133Selective tooth agenesis (HP:0001592)1.91645570
134Hemiparesis (HP:0001269)1.91008787
135Narrow nasal bridge (HP:0000446)1.90728030
136Gait imbalance (HP:0002141)1.90709331
137Pallor (HP:0000980)1.88208845
138Blue irides (HP:0000635)1.86968551
139Hypercalcemia (HP:0003072)1.85584676
140Truncus arteriosus (HP:0001660)1.85260369
141Status epilepticus (HP:0002133)1.84792175
142Conjunctival hamartoma (HP:0100780)1.84360521
143Generalized myoclonic seizures (HP:0002123)1.83176379
144Exercise-induced muscle cramps (HP:0003710)1.83065627
145Dysphonia (HP:0001618)1.82475446
146Flat acetabular roof (HP:0003180)1.82372951
147Abnormality of the corticospinal tract (HP:0002492)1.81485087
148Sudden death (HP:0001699)1.81167532
149Gait ataxia (HP:0002066)1.80286126
150Pointed chin (HP:0000307)1.79770980
151External ophthalmoplegia (HP:0000544)1.79259987
152Abnormality of salivation (HP:0100755)1.79063790
153Multiple lipomas (HP:0001012)1.78719851
154Progressive hearing impairment (HP:0001730)1.78320402
155Ventricular fibrillation (HP:0001663)1.78229201
156Muscle hypertrophy of the lower extremities (HP:0008968)1.77862618
157Inappropriate behavior (HP:0000719)1.77557387
158Sparse lateral eyebrow (HP:0005338)1.77533163
159Abnormality of the calf musculature (HP:0001430)1.75060953
160Hemiplegia (HP:0002301)1.75017284
161Specific learning disability (HP:0001328)1.74883763
162Seborrheic dermatitis (HP:0001051)1.74279658
163Tetraplegia (HP:0002445)1.74200657
164Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73394981
165Abnormality of the gastric mucosa (HP:0004295)1.72293560
166Hypotrichosis (HP:0001006)1.71893464
167Myoglobinuria (HP:0002913)1.71749515
168Hyperphosphatemia (HP:0002905)1.70933056
169Limb dystonia (HP:0002451)1.69980783
170Right ventricular cardiomyopathy (HP:0011663)1.69470555
171Hyperthyroidism (HP:0000836)1.69208707
172Abnormality of the thoracic spine (HP:0100711)1.67822823
173Generalized hypotonia (HP:0001290)1.67797302
174Trismus (HP:0000211)1.67252411
175Congenital primary aphakia (HP:0007707)1.66993075
176Apathy (HP:0000741)1.64623385
177Rhabdomyolysis (HP:0003201)1.63742046
178Fasciculations (HP:0002380)1.63708699
179Personality changes (HP:0000751)1.63651581
180Patellar dislocation (HP:0002999)1.62845499
181Abnormal atrioventricular conduction (HP:0005150)1.62774242
182Macroorchidism (HP:0000053)1.62452783
183Atrioventricular block (HP:0001678)1.62380137
184Neurofibrillary tangles (HP:0002185)1.61898531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.60132733
2EPHA44.65885547
3NTRK34.41757215
4EEF2K3.60744034
5MAP3K123.42660130
6MAP3K93.39868237
7MAP3K43.13676276
8NME23.04159466
9CASK2.99139631
10SMG12.83660802
11MAP2K72.83270605
12DAPK22.81863024
13RIPK42.77364098
14CDK122.56756604
15RPS6KB22.54828488
16SCYL22.53573734
17MINK12.52672020
18SIK12.30343854
19PLK22.29844131
20DAPK12.19022061
21MAPKAPK32.18954030
22KSR22.18045545
23MAP2K42.12248004
24EPHA22.08403577
25ARAF2.00112540
26CDK191.98764891
27ICK1.90201559
28PKN21.87387336
29MARK11.83666399
30KSR11.78938573
31PAK61.76641917
32IRAK31.72754472
33MAP3K131.63580490
34VRK21.60475400
35CAMKK11.55544346
36PRPF4B1.55132355
37GRK51.50180471
38MAP2K21.42665909
39NTRK21.42575676
40PTK2B1.42328715
41CDK51.40729183
42TESK11.40669319
43NTRK11.34001376
44CCNB11.29777918
45MAP3K101.29723636
46RIPK11.22375603
47SIK31.18340817
48PRKD31.16461240
49FES1.13961037
50PRKCG1.12869136
51SIK21.11118070
52MAPK131.10967119
53CAMKK21.10559495
54TESK21.10341810
55BMPR21.06357776
56NME11.04157619
57MAP3K21.02564773
58ERN11.02479698
59CAMK2A0.99194302
60DMPK0.99089265
61MTOR0.94233174
62STK160.93841508
63RAF10.93755555
64NEK10.91287079
65TTN0.90412336
66MARK20.89591163
67CDC70.88929138
68LRRK20.88390321
69TLK10.88078643
70PNCK0.85816302
71FGFR40.85681016
72SGK20.85576817
73CDK180.84965655
74SRPK10.84728991
75STK380.84310675
76NEK60.83431343
77OBSCN0.82957082
78SGK4940.82842163
79SGK2230.82842163
80PHKG10.79579617
81PHKG20.79579617
82CDK140.78699983
83LMTK20.78440121
84CDK150.78193589
85FGR0.74555193
86FER0.74097005
87CAMK2B0.73168307
88EIF2AK10.72966636
89OXSR10.72017974
90PRKCH0.71998146
91PTK60.70268518
92DAPK30.70007976
93UHMK10.69778579
94RET0.69237592
95AKT20.68444756
96MAP2K10.68155642
97CAMK10.68038908
98RPS6KB10.67870147
99ILK0.66936864
100CDK11A0.66283296
101CDK70.65228400
102MAP3K110.65171857
103SGK10.64789764
104TNIK0.63057761
105SGK30.62662929
106PAK40.62612037
107MAP3K10.62029712
108BRAF0.61002121
109AURKA0.60249074
110PDK10.59514522
111PDK30.58893363
112PDK40.58893363
113PBK0.57300101
114PDPK10.55389724
115GRK70.54445539
116TTK0.53958621
117PRKCE0.53734330
118LIMK10.53062908
119TAOK20.51730801
120BRSK10.51640731
121PINK10.51270218
122TYRO30.50632241
123STK110.50496923
124DYRK1A0.50052796
125IRAK20.49774675
126AKT30.49421787
127BRD40.49353265
128PAK30.47028917
129CSNK1E0.46956400
130TNK20.45284680
131GRK60.44301516
132MAPK120.44292522
133BUB10.43610898
134CDK20.42716125
135ADRBK10.42178384
136MYLK0.42100971
137DYRK30.41821938
138CDK40.41040046
139MAPK100.40492685
140LATS20.40188271
141AURKB0.40040029
142CHEK10.38777493
143CHEK20.38061338
144CAMK1D0.37623367
145CAMK2D0.37356699
146CAMK40.37233009
147HIPK20.37140276
148BCR0.36940347
149MAPK110.36632722
150CDK10.36526140
151PRKCI0.36096680
152RPS6KA30.35993688
153RPS6KA20.35794496
154ROCK20.35785744
155TAOK10.35303637
156FYN0.34584819
157ERBB30.34189803
158CAMK2G0.32360680
159MOS0.31435702
160PRKCZ0.30418795
161ALK0.30168998
162MAP3K70.29880674

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.87846672
2Nicotine addiction_Homo sapiens_hsa050333.61479145
3Synaptic vesicle cycle_Homo sapiens_hsa047213.58646187
4Long-term potentiation_Homo sapiens_hsa047202.77308321
5Olfactory transduction_Homo sapiens_hsa047402.68282384
6Circadian entrainment_Homo sapiens_hsa047132.63617108
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61803229
8Amphetamine addiction_Homo sapiens_hsa050312.40808753
9GABAergic synapse_Homo sapiens_hsa047272.39154327
10Collecting duct acid secretion_Homo sapiens_hsa049662.37217895
11Morphine addiction_Homo sapiens_hsa050322.36020490
12Glutamatergic synapse_Homo sapiens_hsa047242.28658829
13Spliceosome_Homo sapiens_hsa030402.11460343
14Dopaminergic synapse_Homo sapiens_hsa047282.09335497
15Salivary secretion_Homo sapiens_hsa049702.05389688
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02521510
17Thyroid cancer_Homo sapiens_hsa052161.95575384
18DNA replication_Homo sapiens_hsa030301.83049227
19Gastric acid secretion_Homo sapiens_hsa049711.80570761
20Renin secretion_Homo sapiens_hsa049241.79736223
21Oxytocin signaling pathway_Homo sapiens_hsa049211.74892837
22Insulin secretion_Homo sapiens_hsa049111.74866815
23Taste transduction_Homo sapiens_hsa047421.71647703
24Cholinergic synapse_Homo sapiens_hsa047251.71441530
25Long-term depression_Homo sapiens_hsa047301.67309983
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64889220
27Calcium signaling pathway_Homo sapiens_hsa040201.61828542
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57669933
29Serotonergic synapse_Homo sapiens_hsa047261.56333455
30Pentose phosphate pathway_Homo sapiens_hsa000301.51757184
31Biosynthesis of amino acids_Homo sapiens_hsa012301.49911722
32Bladder cancer_Homo sapiens_hsa052191.48320598
33Vibrio cholerae infection_Homo sapiens_hsa051101.45761389
34GnRH signaling pathway_Homo sapiens_hsa049121.45001859
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43923191
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40633407
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39361042
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.35307435
39Carbon metabolism_Homo sapiens_hsa012001.31547131
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.29166861
41Cocaine addiction_Homo sapiens_hsa050301.28603682
42Chronic myeloid leukemia_Homo sapiens_hsa052201.27571138
43Phenylalanine metabolism_Homo sapiens_hsa003601.27390385
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26599812
45Vitamin B6 metabolism_Homo sapiens_hsa007501.25285335
46mRNA surveillance pathway_Homo sapiens_hsa030151.24201906
47Acute myeloid leukemia_Homo sapiens_hsa052211.23907548
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23896316
49Gap junction_Homo sapiens_hsa045401.22886207
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19274612
51Glioma_Homo sapiens_hsa052141.16958322
52Cardiac muscle contraction_Homo sapiens_hsa042601.16363512
53cAMP signaling pathway_Homo sapiens_hsa040241.15856769
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15082158
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13235253
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12095827
57AMPK signaling pathway_Homo sapiens_hsa041521.12086323
58Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10955285
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07346433
60Phototransduction_Homo sapiens_hsa047441.06211563
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06112669
62Estrogen signaling pathway_Homo sapiens_hsa049151.05983637
63Fructose and mannose metabolism_Homo sapiens_hsa000511.03999719
64Type II diabetes mellitus_Homo sapiens_hsa049300.99201902
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97483113
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97435731
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95789425
68Oxidative phosphorylation_Homo sapiens_hsa001900.95725975
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95526854
70ErbB signaling pathway_Homo sapiens_hsa040120.95081543
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92192278
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.92036668
73Arginine biosynthesis_Homo sapiens_hsa002200.91313411
74Alzheimers disease_Homo sapiens_hsa050100.91032624
75Melanogenesis_Homo sapiens_hsa049160.90893171
76Axon guidance_Homo sapiens_hsa043600.90475109
77Pancreatic cancer_Homo sapiens_hsa052120.90012074
78Dilated cardiomyopathy_Homo sapiens_hsa054140.86500365
79Base excision repair_Homo sapiens_hsa034100.86359436
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82100287
81Tight junction_Homo sapiens_hsa045300.79921875
82Folate biosynthesis_Homo sapiens_hsa007900.79546092
83RNA transport_Homo sapiens_hsa030130.78314884
84Oocyte meiosis_Homo sapiens_hsa041140.77647909
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76591815
86Rheumatoid arthritis_Homo sapiens_hsa053230.74480776
87VEGF signaling pathway_Homo sapiens_hsa043700.74306728
88Sulfur relay system_Homo sapiens_hsa041220.73422485
89Arginine and proline metabolism_Homo sapiens_hsa003300.72992443
90Notch signaling pathway_Homo sapiens_hsa043300.72884505
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72022628
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.71870279
93Pyruvate metabolism_Homo sapiens_hsa006200.70825206
94MAPK signaling pathway_Homo sapiens_hsa040100.70340381
95Parkinsons disease_Homo sapiens_hsa050120.67814892
96Other glycan degradation_Homo sapiens_hsa005110.65305835
97RNA polymerase_Homo sapiens_hsa030200.65158630
98Pancreatic secretion_Homo sapiens_hsa049720.64976364
99Dorso-ventral axis formation_Homo sapiens_hsa043200.62370030
100Glucagon signaling pathway_Homo sapiens_hsa049220.61855484
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.61477273
102Type I diabetes mellitus_Homo sapiens_hsa049400.60802005
103Prolactin signaling pathway_Homo sapiens_hsa049170.59962589
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58639376
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.58585838
106B cell receptor signaling pathway_Homo sapiens_hsa046620.58556601
107Choline metabolism in cancer_Homo sapiens_hsa052310.56158443
108Thyroid hormone synthesis_Homo sapiens_hsa049180.53567586
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53106969
110Phagosome_Homo sapiens_hsa041450.52651447
111Pyrimidine metabolism_Homo sapiens_hsa002400.52625618
112African trypanosomiasis_Homo sapiens_hsa051430.52496251
113Ras signaling pathway_Homo sapiens_hsa040140.52495391
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51782681
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51355043
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49967395
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49659955
118Cell cycle_Homo sapiens_hsa041100.49302771
119Non-small cell lung cancer_Homo sapiens_hsa052230.49243369
120HIF-1 signaling pathway_Homo sapiens_hsa040660.48234171
121Hepatitis C_Homo sapiens_hsa051600.48228956
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48024007
123Rap1 signaling pathway_Homo sapiens_hsa040150.47468696
124Inositol phosphate metabolism_Homo sapiens_hsa005620.46703390
125Alcoholism_Homo sapiens_hsa050340.46458591
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45610928
127Colorectal cancer_Homo sapiens_hsa052100.45438840
128Insulin signaling pathway_Homo sapiens_hsa049100.44967252
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.44713361
130Chemokine signaling pathway_Homo sapiens_hsa040620.44382427
131Insulin resistance_Homo sapiens_hsa049310.44292961
132mTOR signaling pathway_Homo sapiens_hsa041500.43520967
133Endocytosis_Homo sapiens_hsa041440.42817478
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41662607
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40729103
136Circadian rhythm_Homo sapiens_hsa047100.40471934
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39985723
138Huntingtons disease_Homo sapiens_hsa050160.39366722
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37148268
140Endometrial cancer_Homo sapiens_hsa052130.37146051
141Tuberculosis_Homo sapiens_hsa051520.36877540
142Renal cell carcinoma_Homo sapiens_hsa052110.35412861
143Salmonella infection_Homo sapiens_hsa051320.34603187
144Prion diseases_Homo sapiens_hsa050200.32509268
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31819993
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29425905
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28116835

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