ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	7.14560563
2	regulation of vitamin D biosynthetic process (GO:0060556)	5.47553187
3	auditory receptor cell differentiation (GO:0042491)	5.23568839
4	regulation of vitamin metabolic process (GO:0030656)	5.02029547
5	regulation of mitochondrial fission (GO:0090140)	4.95266115
6	positive regulation of cell fate commitment (GO:0010455)	4.55924483
7	negative regulation of monooxygenase activity (GO:0032769)	4.47884794
8	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	4.39015460
9	UMP biosynthetic process (GO:0006222)	4.39015460
10	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	4.39015460
11	UMP metabolic process (GO:0046049)	4.39015460
12	fucose catabolic process (GO:0019317)	4.26270340
13	L-fucose metabolic process (GO:0042354)	4.26270340
14	L-fucose catabolic process (GO:0042355)	4.26270340
15	regulation of helicase activity (GO:0051095)	4.22722996
16	rRNA catabolic process (GO:0016075)	4.18573046
17	cardiolipin metabolic process (GO:0032048)	3.86221286
18	vitamin biosynthetic process (GO:0009110)	3.83385750
19	cellular response to exogenous dsRNA (GO:0071360)	3.83363293
20	nucleobase biosynthetic process (GO:0046112)	3.78604713
21	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.76807066
22	piRNA metabolic process (GO:0034587)	3.73685816
23	ATP synthesis coupled proton transport (GO:0015986)	3.67979318
24	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.67979318
25	response to pheromone (GO:0019236)	3.59339248
26	sulfur amino acid catabolic process (GO:0000098)	3.55567085
27	protein polyglutamylation (GO:0018095)	3.47931992
28	activated T cell proliferation (GO:0050798)	3.46885898
29	respiratory chain complex IV assembly (GO:0008535)	3.46653169
30	negative regulation of cell fate specification (GO:0009996)	3.42770634
31	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.33246284
32	iron-sulfur cluster assembly (GO:0016226)	3.26512868
33	metallo-sulfur cluster assembly (GO:0031163)	3.26512868
34	regulation of cellular extravasation (GO:0002691)	3.23374710
35	negative regulation of mast cell activation (GO:0033004)	3.20540064
36	maturation of 5.8S rRNA (GO:0000460)	3.19413592
37	DNA methylation involved in gamete generation (GO:0043046)	3.08211143
38	adaptation of signaling pathway (GO:0023058)	3.07487987
39	protein neddylation (GO:0045116)	3.06960513
40	protein targeting to Golgi (GO:0000042)	3.06730924
41	positive regulation of T-helper 1 type immune response (GO:0002827)	3.06275290
42	oxidative phosphorylation (GO:0006119)	3.04212897
43	regulation of regulatory T cell differentiation (GO:0045589)	3.03565715
44	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.02084375
45	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.02084375
46	DNA deamination (GO:0045006)	2.97721260
47	retinal cone cell development (GO:0046549)	2.95281160
48	regulation of interleukin-8 secretion (GO:2000482)	2.88438123
49	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.88371350
50	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.87857409
51	endoderm formation (GO:0001706)	2.85180386
52	mast cell activation (GO:0045576)	2.83756853
53	establishment of protein localization to Golgi (GO:0072600)	2.82845250
54	cellular response to dsRNA (GO:0071359)	2.81733483
55	regulation of T cell chemotaxis (GO:0010819)	2.80955888
56	positive regulation of T cell chemotaxis (GO:0010820)	2.80955888
57	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.80441543
58	mRNA modification (GO:0016556)	2.79692654
59	indolalkylamine metabolic process (GO:0006586)	2.79262780
60	response to caffeine (GO:0031000)	2.78459100
61	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.75210225
62	platelet dense granule organization (GO:0060155)	2.73823761
63	positive thymic T cell selection (GO:0045059)	2.73771267
64	cobalamin metabolic process (GO:0009235)	2.73687136
65	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.72653131
66	positive regulation of lamellipodium assembly (GO:0010592)	2.72418623
67	protein complex biogenesis (GO:0070271)	2.68213391
68	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.66439535
69	fucosylation (GO:0036065)	2.64375406
70	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.63409925
71	mismatch repair (GO:0006298)	2.62882468
72	regulation of defense response to virus by host (GO:0050691)	2.62494580
73	protein kinase C signaling (GO:0070528)	2.62072254
74	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.61895108
75	intra-S DNA damage checkpoint (GO:0031573)	2.61466241
76	hair cell differentiation (GO:0035315)	2.60907208
77	positive regulation of defense response to virus by host (GO:0002230)	2.57792455
78	negative regulation of oxidoreductase activity (GO:0051354)	2.57679342
79	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.57411925
80	fucose metabolic process (GO:0006004)	2.55682428
81	response to interferon-beta (GO:0035456)	2.54372362
82	mitochondrial respiratory chain complex assembly (GO:0033108)	2.53340049
83	regulation of T cell mediated cytotoxicity (GO:0001914)	2.52186851
84	tryptophan metabolic process (GO:0006568)	2.52136409
85	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.51924549
86	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.50855724
87	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.50855724
88	NADH dehydrogenase complex assembly (GO:0010257)	2.50855724
89	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.50095931
90	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.49541100
91	anterograde synaptic vesicle transport (GO:0048490)	2.49252703
92	antigen processing and presentation of endogenous antigen (GO:0019883)	2.49015928
93	cytochrome complex assembly (GO:0017004)	2.48286374
94	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.46837509
95	ncRNA 3-end processing (GO:0043628)	2.46342878
96	positive regulation of mitochondrial fission (GO:0090141)	2.45396611
97	S-adenosylmethionine metabolic process (GO:0046500)	2.44397333
98	mitochondrial RNA metabolic process (GO:0000959)	2.43788076
99	mannosylation (GO:0097502)	2.41933153
100	inner ear receptor cell differentiation (GO:0060113)	2.41890609

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.05632828
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.96995415
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.92637286
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.59310609
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.50816880
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.01715828
7	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.01181759
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.95785386
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79144355
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76739895
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.67627710
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.62215749
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.58875927
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.55388478
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45957992
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.25812961
17	CIITA_25753668_ChIP-Seq_RAJI_Human	2.24712534
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.17088503
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.14472203
20	VDR_22108803_ChIP-Seq_LS180_Human	2.12809612
21	GATA3_26560356_Chip-Seq_TH2_Human	2.12679301
22	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.07849665
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.01972187
24	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.97975494
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.83813043
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.76308637
27	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.74130583
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73673870
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.68254556
30	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.65663033
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.64910943
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64878694
33	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.57899724
34	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.55757329
35	MYB_26560356_Chip-Seq_TH2_Human	1.54867198
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.54616604
37	GATA3_27048872_Chip-Seq_THYMUS_Human	1.50386700
38	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.49499848
39	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.47715146
40	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.47713150
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.47416935
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.47416935
43	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.41338503
44	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.40736984
45	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.40581147
46	GBX2_23144817_ChIP-Seq_PC3_Human	1.38774861
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.37446878
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.36114525
49	EWS_26573619_Chip-Seq_HEK293_Human	1.35318668
50	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.34898399
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32317094
52	SPI1_23547873_ChIP-Seq_NB4_Human	1.30696276
53	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.29362386
54	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.29115463
55	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.27245369
56	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.27110163
57	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.26599684
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.26281755
59	ELF5_23300383_ChIP-Seq_T47D_Human	1.24666313
60	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.15829205
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.14423725
62	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.14265709
63	FUS_26573619_Chip-Seq_HEK293_Human	1.11980218
64	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.11012666
65	PHF8_20622853_ChIP-Seq_HELA_Human	1.09197246
66	GATA3_26560356_Chip-Seq_TH1_Human	1.08066766
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.07645256
68	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.07470228
69	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.07318687
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06173406
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05217371
72	DCP1A_22483619_ChIP-Seq_HELA_Human	1.05111684
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04789300
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04789300
75	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04356754
76	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.03949315
77	RBPJ_21746931_ChIP-Seq_IB4_Human	1.03533936
78	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.03291288
79	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.03238000
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.02426018
81	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.01574686
82	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00741862
83	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99911225
84	STAT1_20625510_ChIP-Seq_HELA_Human	0.99713529
85	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99273503
86	MYC_19829295_ChIP-Seq_ESCs_Human	0.97894375
87	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.97612817
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96615128
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95837350
90	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94799109
91	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94465971
92	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.94425111
93	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.94085750
94	TAF15_26573619_Chip-Seq_HEK293_Human	0.93293882
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93134918
96	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.93108505
97	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.91984931
98	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.91925662
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91737508
100	RAC3_21632823_ChIP-Seq_H3396_Human	0.90714065

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009780_abnormal_chondrocyte_physiolo	4.59258344
2	MP0003183_abnormal_peptide_metabolism	3.79941213
3	MP0003724_increased_susceptibility_to	3.46826305
4	MP0008877_abnormal_DNA_methylation	3.01701984
5	MP0006054_spinal_hemorrhage	2.99914970
6	MP0001835_abnormal_antigen_presentation	2.97749001
7	MP0000516_abnormal_urinary_system	2.75993058
8	MP0005367_renal/urinary_system_phenotyp	2.75993058
9	MP0005671_abnormal_response_to	2.40045299
10	MP0003011_delayed_dark_adaptation	2.31280136
11	MP0003646_muscle_fatigue	2.18689621
12	MP0009785_altered_susceptibility_to	2.14698899
13	MP0002138_abnormal_hepatobiliary_system	1.98657022
14	MP0002876_abnormal_thyroid_physiology	1.94673707
15	MP0002148_abnormal_hypersensitivity_rea	1.85276322
16	MP0003786_premature_aging	1.83351171
17	MP0003567_abnormal_fetal_cardiomyocyte	1.82412029
18	MP0008007_abnormal_cellular_replicative	1.80189474
19	MP0003172_abnormal_lysosome_physiology	1.77141642
20	MP0008058_abnormal_DNA_repair	1.71430387
21	MP0005387_immune_system_phenotype	1.70612093
22	MP0001790_abnormal_immune_system	1.70612093
23	MP0001800_abnormal_humoral_immune	1.70334170
24	MP0005167_abnormal_blood-brain_barrier	1.69954619
25	MP0005075_abnormal_melanosome_morpholog	1.67136986
26	MP0001873_stomach_inflammation	1.59480958
27	MP0004782_abnormal_surfactant_physiolog	1.57683910
28	MP0003763_abnormal_thymus_physiology	1.57377734
29	MP0003866_abnormal_defecation	1.54596331
30	MP0002723_abnormal_immune_serum	1.53568801
31	MP0000569_abnormal_digit_pigmentation	1.51382636
32	MP0000685_abnormal_immune_system	1.48160981
33	MP0002420_abnormal_adaptive_immunity	1.46989489
34	MP0001819_abnormal_immune_cell	1.45416431
35	MP0006035_abnormal_mitochondrial_morpho	1.39192643
36	MP0002234_abnormal_pharynx_morphology	1.37420711
37	MP0001485_abnormal_pinna_reflex	1.31607198
38	MP0005000_abnormal_immune_tolerance	1.30979158
39	MP0005319_abnormal_enzyme/_coenzyme	1.29869999
40	MP0006036_abnormal_mitochondrial_physio	1.29032568
41	MP0002452_abnormal_antigen_presenting	1.26142928
42	MP0003045_fibrosis	1.24068091
43	MP0010307_abnormal_tumor_latency	1.22924570
44	MP0005365_abnormal_bile_salt	1.22457082
45	MP0003195_calcinosis	1.17873346
46	MP0010368_abnormal_lymphatic_system	1.15098659
47	MP0002837_dystrophic_cardiac_calcinosis	1.14905389
48	MP0004147_increased_porphyrin_level	1.13954945
49	MP0000703_abnormal_thymus_morphology	1.13020337
50	MP0004742_abnormal_vestibular_system	1.12733126
51	MP0008469_abnormal_protein_level	1.12318127
52	MP0005332_abnormal_amino_acid	1.10890720
53	MP0006082_CNS_inflammation	1.10691413
54	MP0002398_abnormal_bone_marrow	1.07486402
55	MP0001666_abnormal_nutrient_absorption	1.06946940
56	MP0003787_abnormal_imprinting	1.05153374
57	MP0001968_abnormal_touch/_nociception	1.05011037
58	MP0005646_abnormal_pituitary_gland	1.04774090
59	MP0000716_abnormal_immune_system	1.04108398
60	MP0009697_abnormal_copulation	1.02869795
61	MP0005025_abnormal_response_to	1.02094325
62	MP0003186_abnormal_redox_activity	0.96038319
63	MP0003283_abnormal_digestive_organ	0.94730083
64	MP0002139_abnormal_hepatobiliary_system	0.93656351
65	MP0009764_decreased_sensitivity_to	0.93528904
66	MP0001501_abnormal_sleep_pattern	0.93255408
67	MP0010155_abnormal_intestine_physiology	0.92674719
68	MP0005379_endocrine/exocrine_gland_phen	0.92167048
69	MP0000465_gastrointestinal_hemorrhage	0.91966866
70	MP0002736_abnormal_nociception_after	0.91676002
71	MP0001191_abnormal_skin_condition	0.90955411
72	MP0000358_abnormal_cell_content/	0.90290897
73	MP0005464_abnormal_platelet_physiology	0.89890050
74	MP0002419_abnormal_innate_immunity	0.89669904
75	MP0001905_abnormal_dopamine_level	0.88417460
76	MP0002405_respiratory_system_inflammati	0.88386170
77	MP0008875_abnormal_xenobiotic_pharmacok	0.88023563
78	MP0001845_abnormal_inflammatory_respons	0.87725409
79	MP0000689_abnormal_spleen_morphology	0.86759209
80	MP0005166_decreased_susceptibility_to	0.86640617
81	MP0005551_abnormal_eye_electrophysiolog	0.84988789
82	MP0002722_abnormal_immune_system	0.84281084
83	MP0004947_skin_inflammation	0.84018991
84	MP0002429_abnormal_blood_cell	0.83735245
85	MP0002277_abnormal_respiratory_mucosa	0.83024961
86	MP0003075_altered_response_to	0.82626538
87	MP0001765_abnormal_ion_homeostasis	0.81011789
88	MP0002166_altered_tumor_susceptibility	0.80445641
89	MP0009643_abnormal_urine_homeostasis	0.80185994
90	MP0008873_increased_physiological_sensi	0.77546661
91	MP0005174_abnormal_tail_pigmentation	0.77114319
92	MP0009765_abnormal_xenobiotic_induced	0.76746911
93	MP0002693_abnormal_pancreas_physiology	0.75757411
94	MP0005645_abnormal_hypothalamus_physiol	0.75379435
95	MP0003303_peritoneal_inflammation	0.75168434
96	MP0003693_abnormal_embryo_hatching	0.74713716
97	MP0004036_abnormal_muscle_relaxation	0.73950290
98	MP0005636_abnormal_mineral_homeostasis	0.72795821
99	MP0002332_abnormal_exercise_endurance	0.71767161
100	MP0000013_abnormal_adipose_tissue	0.71647442

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Renal cortical cysts (HP:0000803)	7.24113515
2	B lymphocytopenia (HP:0010976)	4.99615645
3	Abnormality of B cell number (HP:0010975)	4.90363756
4	Methylmalonic acidemia (HP:0002912)	4.38597690
5	Abnormality of the renal cortex (HP:0011035)	4.17921122
6	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	4.04718061
7	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.97255570
8	Aplastic anemia (HP:0001915)	3.91032659
9	Acute necrotizing encephalopathy (HP:0006965)	3.57162298
10	Methylmalonic aciduria (HP:0012120)	3.43704356
11	Acute encephalopathy (HP:0006846)	3.36693785
12	Mitochondrial inheritance (HP:0001427)	3.29260922
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.24825493
14	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.22519652
15	Dicarboxylic aciduria (HP:0003215)	3.22519652
16	Hyperglycinemia (HP:0002154)	3.20187286
17	3-Methylglutaconic aciduria (HP:0003535)	3.19854880
18	Increased CSF lactate (HP:0002490)	3.13249843
19	Progressive macrocephaly (HP:0004481)	3.09578454
20	Increased IgM level (HP:0003496)	3.07453790
21	Disproportionate short-trunk short stature (HP:0003521)	3.04615871
22	Conical tooth (HP:0000698)	2.97767429
23	Lipid accumulation in hepatocytes (HP:0006561)	2.95688101
24	Hepatocellular necrosis (HP:0001404)	2.93443903
25	IgG deficiency (HP:0004315)	2.86439934
26	Increased hepatocellular lipid droplets (HP:0006565)	2.80908796
27	Abolished electroretinogram (ERG) (HP:0000550)	2.79987082
28	Congenital stationary night blindness (HP:0007642)	2.78264034
29	Abnormality of vitamin B metabolism (HP:0004340)	2.77638893
30	Hepatic necrosis (HP:0002605)	2.66455084
31	Lactic acidosis (HP:0003128)	2.64907666
32	Increased intramyocellular lipid droplets (HP:0012240)	2.61616156
33	Chronic diarrhea (HP:0002028)	2.60587649
34	Stomatitis (HP:0010280)	2.59038067
35	Hyperammonemia (HP:0001987)	2.58464040
36	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.57512892
37	Pancytopenia (HP:0001876)	2.56837769
38	Pancreatic cysts (HP:0001737)	2.48563943
39	Attenuation of retinal blood vessels (HP:0007843)	2.47752958
40	Ketosis (HP:0001946)	2.47150558
41	Supernumerary bones of the axial skeleton (HP:0009144)	2.41837256
42	Increased muscle lipid content (HP:0009058)	2.37447412
43	Congenital sensorineural hearing impairment (HP:0008527)	2.35894771
44	Acute hepatic failure (HP:0006554)	2.35000865
45	Hypoplasia of the radius (HP:0002984)	2.34268321
46	Cleft eyelid (HP:0000625)	2.32207011
47	Facial diplegia (HP:0001349)	2.32189494
48	Metabolic acidosis (HP:0001942)	2.30454195
49	Hyperventilation (HP:0002883)	2.30451024
50	Increased serum lactate (HP:0002151)	2.27624459
51	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.27058574
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.27058574
53	Hypoplastic ischia (HP:0003175)	2.26021302
54	Petechiae (HP:0000967)	2.25547470
55	Ectropion (HP:0000656)	2.22997106
56	Severe combined immunodeficiency (HP:0004430)	2.21279272
57	Abnormality of glycine metabolism (HP:0010895)	2.15502321
58	Abnormality of serine family amino acid metabolism (HP:0010894)	2.15502321
59	Cerebral edema (HP:0002181)	2.13628512
60	Respiratory failure (HP:0002878)	2.13215815
61	Neutropenia (HP:0001875)	2.12632689
62	Renal Fanconi syndrome (HP:0001994)	2.12307734
63	Chromsome breakage (HP:0040012)	2.11806451
64	Acute myeloid leukemia (HP:0004808)	2.11700989
65	Abnormality of oral frenula (HP:0000190)	2.11529339
66	Hypoalbuminemia (HP:0003073)	2.11119733
67	Abnormal albumin level (HP:0012116)	2.11119733
68	Ragged-red muscle fibers (HP:0003200)	2.10610553
69	Elevated erythrocyte sedimentation rate (HP:0003565)	2.06967767
70	Brushfield spots (HP:0001088)	2.06369387
71	Clitoromegaly (HP:0000057)	2.05920983
72	Stomach cancer (HP:0012126)	2.04682036
73	Absent/shortened dynein arms (HP:0200106)	2.01044365
74	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01044365
75	Pancreatic fibrosis (HP:0100732)	2.01010414
76	Exercise intolerance (HP:0003546)	1.99676064
77	Abnormal drinking behavior (HP:0030082)	1.99019439
78	Polydipsia (HP:0001959)	1.99019439
79	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.98858978
80	True hermaphroditism (HP:0010459)	1.96417238
81	Abnormality of vitamin metabolism (HP:0100508)	1.96078627
82	Abnormality of the radial head (HP:0003995)	1.94597592
83	Cupped ear (HP:0000378)	1.93310035
84	Hypoproteinemia (HP:0003075)	1.91156160
85	Dislocated radial head (HP:0003083)	1.88892824
86	Colon cancer (HP:0003003)	1.88232081
87	Testicular atrophy (HP:0000029)	1.84940099
88	Lethargy (HP:0001254)	1.83955018
89	Abnormality of the prostate (HP:0008775)	1.82058267
90	Intestinal atresia (HP:0011100)	1.81746066
91	Abnormality of midbrain morphology (HP:0002418)	1.81687121
92	Molar tooth sign on MRI (HP:0002419)	1.81687121
93	Progressive inability to walk (HP:0002505)	1.81168414
94	Papilledema (HP:0001085)	1.80897844
95	Congenital, generalized hypertrichosis (HP:0004540)	1.80752262
96	Pustule (HP:0200039)	1.80181532
97	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.77540198
98	Abnormal foot bone ossification (HP:0010675)	1.75994774
99	Prostate neoplasm (HP:0100787)	1.74551762
100	Abnormality of the alveolar ridges (HP:0006477)	1.74082689

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.72797823
2	SCYL2	6.02065407
3	TIE1	5.93180674
4	MAP4K1	4.37329935
5	TAF1	4.21165827
6	VRK2	2.97565489
7	MAP4K2	2.87997949
8	GRK1	2.41237624
9	NUAK1	2.03734928
10	NEK9	1.96356713
11	TLK1	1.83373019
12	PBK	1.77144316
13	MAPKAPK3	1.74431678
14	KIT	1.63497069
15	TEC	1.46737484
16	FES	1.34288968
17	KDR	1.23005930
18	ZAP70	1.21538479
19	WNK4	1.14376839
20	FLT3	1.09531039
21	TNIK	1.08484200
22	CCNB1	1.07437161
23	VRK1	1.06941762
24	MAPKAPK5	1.06869347
25	BMPR1B	1.06002664
26	MAP3K14	1.05003619
27	SMG1	1.03717862
28	DAPK1	0.98971078
29	ADRBK2	0.94313848
30	CSNK1G3	0.90309209
31	EIF2AK2	0.89235082
32	ZAK	0.87940239
33	BCKDK	0.86065403
34	STK39	0.82536136
35	CSNK1A1L	0.80743093
36	MAP3K12	0.78758780
37	RPS6KA5	0.77029047
38	SIK2	0.75462830
39	PHKG2	0.73676296
40	PHKG1	0.73676296
41	CSNK1G2	0.71400075
42	STK4	0.68516632
43	CLK1	0.68499045
44	CAMKK2	0.67685468
45	SIK3	0.67300289
46	CSNK1G1	0.67179279
47	SYK	0.66438048
48	GRK5	0.62846726
49	RIPK1	0.60404090
50	DMPK	0.59677214
51	EIF2AK3	0.58938301
52	BMPR2	0.57821304
53	IRAK3	0.57338940
54	IRAK1	0.57270211
55	GRK7	0.55059140
56	HCK	0.53420633
57	OXSR1	0.52116144
58	MAP2K2	0.50000259
59	RPS6KA4	0.49982348
60	ERN1	0.49634995
61	CDK8	0.48624305
62	IKBKB	0.47926210
63	CHEK2	0.47655043
64	MARK3	0.47479024
65	BRSK1	0.46724525
66	MAPK11	0.46035155
67	PRKCQ	0.45111635
68	CSK	0.44374524
69	NME2	0.44356166
70	TESK2	0.44075370
71	LYN	0.43584551
72	CDK9	0.42288692
73	LCK	0.41512819
74	FER	0.40635645
75	LMTK2	0.40138763
76	BRD4	0.39412067
77	PAK3	0.39202137
78	BTK	0.37918446
79	BRSK2	0.36352283
80	ACVR1B	0.36075600
81	STK10	0.34351775
82	MAP2K3	0.34114662
83	INSRR	0.33210072
84	EPHA4	0.31610301
85	TGFBR2	0.31467747
86	PIM2	0.31460154
87	IGF1R	0.30712524
88	STK16	0.29907343
89	ITK	0.29048156
90	MST4	0.28927343
91	ERBB3	0.28038511
92	TAOK3	0.27583107
93	MAPK13	0.27464490
94	PRKAA2	0.27215055
95	JAK3	0.26400559
96	TBK1	0.25727444
97	PRKCI	0.24691418
98	MATK	0.21443231
99	MKNK1	0.20320166
100	ABL1	0.19606672

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur metabolism_Homo sapiens_hsa00920	5.95546356
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.16849409
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.87367587
4	Asthma_Homo sapiens_hsa05310	2.73972746
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.73545616
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.31299727
7	Regulation of autophagy_Homo sapiens_hsa04140	2.26286512
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.13494855
9	Allograft rejection_Homo sapiens_hsa05330	2.12053595
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.02164343
11	Proteasome_Homo sapiens_hsa03050	1.93716196
12	Graft-versus-host disease_Homo sapiens_hsa05332	1.86845045
13	Parkinsons disease_Homo sapiens_hsa05012	1.82305908
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.78388628
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.76344081
16	Rheumatoid arthritis_Homo sapiens_hsa05323	1.75109839
17	Phototransduction_Homo sapiens_hsa04744	1.71180728
18	Basal transcription factors_Homo sapiens_hsa03022	1.66796757
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.64669861
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.62280270
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.57936436
22	Protein export_Homo sapiens_hsa03060	1.57841209
23	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.51583225
24	Homologous recombination_Homo sapiens_hsa03440	1.46492335
25	One carbon pool by folate_Homo sapiens_hsa00670	1.41044531
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.40631820
27	Alzheimers disease_Homo sapiens_hsa05010	1.35301816
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.31782266
29	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.31231015
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.27316565
31	Base excision repair_Homo sapiens_hsa03410	1.24240594
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23011986
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.21507539
34	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.19953589
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.19710379
36	Huntingtons disease_Homo sapiens_hsa05016	1.19644009
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.15409354
38	RNA polymerase_Homo sapiens_hsa03020	1.12513395
39	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.12204452
40	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.09033713
41	Mismatch repair_Homo sapiens_hsa03430	1.08065063
42	Peroxisome_Homo sapiens_hsa04146	1.07318772
43	Caffeine metabolism_Homo sapiens_hsa00232	1.07202472
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.05279885
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04844590
46	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.03692420
47	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.02536011
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92189480
49	Viral myocarditis_Homo sapiens_hsa05416	0.90494693
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.87555301
51	RNA degradation_Homo sapiens_hsa03018	0.84782081
52	Fatty acid elongation_Homo sapiens_hsa00062	0.84215863
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.83899090
54	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.81195722
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79694423
56	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.79143433
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77334035
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77182681
59	Sulfur relay system_Homo sapiens_hsa04122	0.73117245
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.70890337
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70160258
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69870529
63	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.69159181
64	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.68944240
65	Leishmaniasis_Homo sapiens_hsa05140	0.68904669
66	Other glycan degradation_Homo sapiens_hsa00511	0.68873762
67	DNA replication_Homo sapiens_hsa03030	0.67855085
68	Purine metabolism_Homo sapiens_hsa00230	0.62093554
69	Herpes simplex infection_Homo sapiens_hsa05168	0.61844906
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60151370
71	Metabolic pathways_Homo sapiens_hsa01100	0.57484370
72	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.57355949
73	Pancreatic secretion_Homo sapiens_hsa04972	0.56640638
74	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54568555
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53060000
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.48524436
77	Lysosome_Homo sapiens_hsa04142	0.47858774
78	Ribosome_Homo sapiens_hsa03010	0.45988844
79	Butanoate metabolism_Homo sapiens_hsa00650	0.44786203
80	Measles_Homo sapiens_hsa05162	0.44150920
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43827412
82	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42600676
83	Circadian rhythm_Homo sapiens_hsa04710	0.40737288
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40109844
85	RNA transport_Homo sapiens_hsa03013	0.39525021
86	Glutathione metabolism_Homo sapiens_hsa00480	0.39157787
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38945227
88	Retinol metabolism_Homo sapiens_hsa00830	0.37489706
89	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37428463
90	Linoleic acid metabolism_Homo sapiens_hsa00591	0.36442358
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34450375
92	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.33931904
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.33073109
94	Fanconi anemia pathway_Homo sapiens_hsa03460	0.31656082
95	Shigellosis_Homo sapiens_hsa05131	0.31140596
96	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29635122
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29246456
98	ABC transporters_Homo sapiens_hsa02010	0.29136480
99	Legionellosis_Homo sapiens_hsa05134	0.26759518
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25930767

ENSAP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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