ENTHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.70876852
2cell-cell recognition (GO:0009988)9.60435075
3cell wall macromolecule metabolic process (GO:0044036)9.42151908
4cell wall macromolecule catabolic process (GO:0016998)9.42151908
5spermatid development (GO:0007286)9.17427814
6motile cilium assembly (GO:0044458)9.13193263
7epithelial cilium movement (GO:0003351)8.99587841
8plasma membrane fusion (GO:0045026)8.99414321
9male meiosis (GO:0007140)8.60081099
10synaptonemal complex organization (GO:0070193)8.37221000
11synaptonemal complex assembly (GO:0007130)8.12806079
12reproduction (GO:0000003)8.10118695
13regulation of cilium movement (GO:0003352)7.73822815
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.60115900
15cilium movement (GO:0003341)7.57709409
16single fertilization (GO:0007338)6.76888847
17negative regulation of inclusion body assembly (GO:0090084)6.67907374
18DNA methylation involved in gamete generation (GO:0043046)6.46300675
19sperm capacitation (GO:0048240)6.39125195
20spermatogenesis (GO:0007283)6.27844295
21male gamete generation (GO:0048232)6.25784693
22male meiosis I (GO:0007141)6.08788827
23fertilization (GO:0009566)6.02396699
24gamete generation (GO:0007276)5.74365760
25microtubule depolymerization (GO:0007019)5.73478573
26neutrophil activation involved in immune response (GO:0002283)5.70184705
27chromosome organization involved in meiosis (GO:0070192)5.66655645
28meiotic nuclear division (GO:0007126)5.34524159
29germ cell development (GO:0007281)5.33561303
30organic cation transport (GO:0015695)5.29765706
31regulation of inclusion body assembly (GO:0090083)5.27650660
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.26654978
33meiosis I (GO:0007127)4.99808081
34seminiferous tubule development (GO:0072520)4.94010794
35ventricular system development (GO:0021591)4.83058362
36DNA synthesis involved in DNA repair (GO:0000731)4.59898057
37chromosome condensation (GO:0030261)4.56866902
38protein neddylation (GO:0045116)4.52831030
39meiotic cell cycle (GO:0051321)4.50913125
40cell recognition (GO:0008037)4.49755458
41multicellular organismal reproductive process (GO:0048609)4.48805848
42regulation of microtubule-based movement (GO:0060632)4.47161299
43DNA packaging (GO:0006323)4.42937950
44calcium ion-dependent exocytosis (GO:0017156)4.42178224
45microtubule severing (GO:0051013)4.39413066
46regulation of T-helper 1 cell differentiation (GO:0045625)4.39194959
47adenosine receptor signaling pathway (GO:0001973)4.15449209
48left/right pattern formation (GO:0060972)4.15373540
49gene silencing by RNA (GO:0031047)4.08575346
50regulation of female receptivity (GO:0045924)4.02652180
51regulation of chronic inflammatory response (GO:0002676)4.00923412
52chaperone-mediated protein complex assembly (GO:0051131)4.00548032
53protein localization to cilium (GO:0061512)3.95416560
54spermatid nucleus differentiation (GO:0007289)3.94086854
55monoubiquitinated protein deubiquitination (GO:0035520)3.83645271
56glycosphingolipid catabolic process (GO:0046479)3.83056105
57genitalia morphogenesis (GO:0035112)3.81561039
58low-density lipoprotein particle remodeling (GO:0034374)3.73975312
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.73153756
60female mating behavior (GO:0060180)3.72365251
61regulation of platelet activation (GO:0010543)3.65630929
62glycerol ether metabolic process (GO:0006662)3.64520257
63negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.62256522
64thrombin receptor signaling pathway (GO:0070493)3.61791473
65multicellular organismal development (GO:0007275)3.61599886
66mitotic sister chromatid cohesion (GO:0007064)3.60259840
67meiotic cell cycle process (GO:1903046)3.59458414
68granulocyte activation (GO:0036230)3.51597061
69positive regulation of cAMP-mediated signaling (GO:0043950)3.51257894
70regulation of memory T cell differentiation (GO:0043380)3.47583865
71regulation of spindle checkpoint (GO:0090231)3.46343939
72regulation of vitamin D biosynthetic process (GO:0060556)3.46065022
73nuclear pore complex assembly (GO:0051292)3.41852171
74glycolipid catabolic process (GO:0019377)3.41275315
75positive regulation of mast cell activation (GO:0033005)3.39268549
76regulation of meiosis I (GO:0060631)3.38073394
77cellular response to thyroid hormone stimulus (GO:0097067)3.36611345
78protein polyglutamylation (GO:0018095)3.36183272
79regulation of integrin-mediated signaling pathway (GO:2001044)3.35538848
80ether metabolic process (GO:0018904)3.34262594
81positive regulation of T-helper cell differentiation (GO:0045624)3.31321271
82negative regulation of interleukin-17 production (GO:0032700)3.30901568
83neutrophil activation (GO:0042119)3.29808441
84positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.28779053
85regulation of macrophage derived foam cell differentiation (GO:0010743)3.27795440
86synapsis (GO:0007129)3.25726371
87negative regulation of platelet activation (GO:0010544)3.21714688
88positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.19320951
89sequestering of actin monomers (GO:0042989)3.19221465
90gene silencing (GO:0016458)3.17642985
91nucleus organization (GO:0006997)3.16683016
92regulation of immunoglobulin secretion (GO:0051023)3.06340332
93regulation of integrin activation (GO:0033623)3.06236133
94regulation of platelet aggregation (GO:0090330)3.06184695
95protein refolding (GO:0042026)3.05235833
96positive regulation of macrophage differentiation (GO:0045651)3.04994874
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.04470529
98peptide catabolic process (GO:0043171)3.01847040
99intraciliary transport (GO:0042073)3.00644995
100interferon-gamma secretion (GO:0072643)2.98009991
101positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.97929169
102positive regulation of type 2 immune response (GO:0002830)2.97469665
103ceramide catabolic process (GO:0046514)2.97448514
104axoneme assembly (GO:0035082)2.96574512
105leukocyte degranulation (GO:0043299)2.96326981
106negative regulation of organelle assembly (GO:1902116)2.95538429
107negative regulation of interleukin-12 production (GO:0032695)2.92540887
108positive regulation of DNA recombination (GO:0045911)2.92462351
109glycolytic process (GO:0006096)2.92091495
110regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.89882400
111carnitine transport (GO:0015879)2.88298893
112amino-acid betaine transport (GO:0015838)2.88298893
113regulation of centriole replication (GO:0046599)2.87446086
114single strand break repair (GO:0000012)2.86019344
115angiogenesis involved in wound healing (GO:0060055)2.85523911
116microtubule-based movement (GO:0007018)2.84750260
117negative regulation of norepinephrine secretion (GO:0010700)2.84022268
118carnitine transmembrane transport (GO:1902603)2.83408990
119positive regulation of tissue remodeling (GO:0034105)2.82864453
120myeloid cell activation involved in immune response (GO:0002275)2.82121459
121positive regulation of mast cell activation involved in immune response (GO:0033008)2.80629024
122positive regulation of mast cell degranulation (GO:0043306)2.80629024
123oligosaccharide catabolic process (GO:0009313)2.80552396
124regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.80030951
125negative regulation of lipid storage (GO:0010888)2.79678692
126regulation of mast cell activation (GO:0033003)2.79059779
127cellular biogenic amine catabolic process (GO:0042402)2.78421757
128amine catabolic process (GO:0009310)2.78421757
129positive regulation of osteoclast differentiation (GO:0045672)2.78081322
130amino sugar catabolic process (GO:0046348)2.76389197
131microtubule polymerization or depolymerization (GO:0031109)2.75137533
132lactate metabolic process (GO:0006089)2.74323885
133regulation of interleukin-17 production (GO:0032660)2.73255288
134regulation of podosome assembly (GO:0071801)2.73048781
135RNA localization (GO:0006403)2.72892562
136nuclear pore organization (GO:0006999)2.72784852
137positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.72691049
138positive regulation of interleukin-17 production (GO:0032740)2.72187523
139regulation of T-helper cell differentiation (GO:0045622)2.72172423
140dendritic cell chemotaxis (GO:0002407)2.71534962
141positive regulation of cellular amide metabolic process (GO:0034250)2.70904754
142purinergic nucleotide receptor signaling pathway (GO:0035590)2.70845081
143positive regulation of interleukin-12 production (GO:0032735)2.70004303
144protein localization to chromosome, centromeric region (GO:0071459)2.69988093
145protein K11-linked deubiquitination (GO:0035871)2.69796809
146negative regulation of homotypic cell-cell adhesion (GO:0034111)2.69790899
147regulation of mast cell degranulation (GO:0043304)2.66378430
148regulation of MHC class II biosynthetic process (GO:0045346)2.66297492
149positive regulation of NF-kappaB import into nucleus (GO:0042346)2.66285948
150lipoxygenase pathway (GO:0019372)2.66137239
151regulation of mast cell activation involved in immune response (GO:0033006)2.64158933
152DNA methylation (GO:0006306)2.63687199
153DNA alkylation (GO:0006305)2.63687199
154lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63171179
155pore complex assembly (GO:0046931)2.62548416
156cilium organization (GO:0044782)2.61794711
157purinergic receptor signaling pathway (GO:0035587)2.60754659
158nucleoside diphosphate phosphorylation (GO:0006165)2.60501932
159protein-DNA complex disassembly (GO:0032986)2.59950672
160nucleosome disassembly (GO:0006337)2.59950672
161regulation of histone H3-K9 methylation (GO:0051570)2.59767920
162polyol catabolic process (GO:0046174)2.59715104
163superoxide anion generation (GO:0042554)2.59051377
164heterochromatin organization (GO:0070828)2.58600790
165positive regulation of toll-like receptor signaling pathway (GO:0034123)2.58324275
166response to peptidoglycan (GO:0032494)2.56296716
167regulation of norepinephrine secretion (GO:0014061)2.56257990
168regulation of vitamin metabolic process (GO:0030656)2.56171645
169regulation of interleukin-12 production (GO:0032655)2.54115528
170intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.53271748
171positive regulation of alpha-beta T cell proliferation (GO:0046641)2.52947824
172regulation of T-helper 1 type immune response (GO:0002825)2.52903224
173beta-amyloid metabolic process (GO:0050435)2.50786895
174positive regulation of bone remodeling (GO:0046852)2.49932825
175positive regulation of bone resorption (GO:0045780)2.49932825
176tryptophan catabolic process (GO:0006569)2.49925875
177indole-containing compound catabolic process (GO:0042436)2.49925875
178indolalkylamine catabolic process (GO:0046218)2.49925875
179sperm motility (GO:0030317)12.4573299
180fusion of sperm to egg plasma membrane (GO:0007342)11.9829554
181cilium or flagellum-dependent cell motility (GO:0001539)11.9693713
182sperm-egg recognition (GO:0035036)10.6908498
183acrosome assembly (GO:0001675)10.6349997
184acrosome reaction (GO:0007340)10.6289764
185piRNA metabolic process (GO:0034587)10.1691037
186axonemal dynein complex assembly (GO:0070286)10.0339068
187binding of sperm to zona pellucida (GO:0007339)10.0173059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.45609908
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.12458725
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.53623320
4SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.52264763
5GATA1_22025678_ChIP-Seq_K562_Human3.40634281
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.20194618
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15849061
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.13982734
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.09164108
10SCL_19346495_ChIP-Seq_HPC-7_Human2.87240944
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74782985
12* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.72880180
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70086588
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69641067
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66376778
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.57682573
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51437445
18SPI1_23127762_ChIP-Seq_K562_Human2.46417602
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43209675
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.38001135
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36276917
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35107888
23* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.27428627
24GATA1_26923725_Chip-Seq_HPCs_Mouse2.23373486
25GATA1_19941826_ChIP-Seq_K562_Human2.15115340
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12787541
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10423480
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06906248
29ELK4_26923725_Chip-Seq_MESODERM_Mouse2.05839455
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05645829
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02864361
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.7630990
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93915467
34GATA2_19941826_ChIP-Seq_K562_Human1.93374852
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.92403254
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87286603
37ZNF274_21170338_ChIP-Seq_K562_Hela1.85317477
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.78556107
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76682835
40STAT1_20625510_ChIP-Seq_HELA_Human1.71880310
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70702234
42VDR_24787735_ChIP-Seq_THP-1_Human1.69832290
43* EZH2_22144423_ChIP-Seq_EOC_Human1.69225896
44VDR_22108803_ChIP-Seq_LS180_Human1.69035543
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.68737882
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67963680
47* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67857175
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.65610028
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65061299
50STAT1_17558387_ChIP-Seq_HELA_Human1.56539488
51TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.55509157
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53200014
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52574745
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45423624
55SOX2_22085726_ChIP-Seq_NPCs_Mouse1.44594741
56FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.43111576
57* GATA3_21867929_ChIP-Seq_CD8_Mouse1.40769073
58LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36855526
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34776946
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34337306
61* WDR5_24793694_ChIP-Seq_LNCAP_Human1.33387507
62* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33121070
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.28594287
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28237398
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27066689
66MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26562658
67SPI1_23547873_ChIP-Seq_NB4_Human1.26352734
68SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24913636
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23990977
70CBP_20019798_ChIP-Seq_JUKART_Human1.23990977
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21339629
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.20623626
73GBX2_23144817_ChIP-Seq_PC3_Human1.18637770
74* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18436396
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18204791
76TAF15_26573619_Chip-Seq_HEK293_Human1.18062610
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17792426
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.17263572
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16721427
80* P53_21459846_ChIP-Seq_SAOS-2_Human1.16149779
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16069702
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15707126
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14362574
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.14151938
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13486612
86GATA3_26560356_Chip-Seq_TH2_Human1.13441955
87CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13182389
88PU_27001747_Chip-Seq_BMDM_Mouse1.11924887
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11906686
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10720323
91HTT_18923047_ChIP-ChIP_STHdh_Human1.10114854
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08991669
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08812353
94SPI1_26923725_Chip-Seq_HPCs_Mouse1.08591593
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08506016
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.08429529
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08384279
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.08359293
99* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08323165
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07985727
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07762534
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.07711738
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07695496
104SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07626763
105RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07583478
106* KDM2B_26808549_Chip-Seq_REH_Human1.06980113
107* GATA3_21867929_ChIP-Seq_TH1_Mouse1.06825884
108CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06647381
109ER_23166858_ChIP-Seq_MCF-7_Human1.06624609
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06564801
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05977580
112RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05447235
113* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04634951
114FLI1_21867929_ChIP-Seq_CD8_Mouse1.03408607
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02693285
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02611497
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02188490
118RUNX_20019798_ChIP-Seq_JUKART_Human1.02174821
119ELF1_20517297_ChIP-Seq_JURKAT_Human1.01836490
120KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01638454
121GF1_26923725_Chip-Seq_HPCs_Mouse1.00128889
122GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99166954
123SALL4_22934838_ChIP-ChIP_CD34+_Human0.99042341
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98722130
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98722130
126REST_21632747_ChIP-Seq_MESCs_Mouse0.97303104
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96947443
128RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96909103
129PHF8_20622854_ChIP-Seq_HELA_Human0.96080211
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.95146933
131GATA3_27048872_Chip-Seq_THYMUS_Human0.94901543
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94694575
133MYC_27129775_Chip-Seq_CORNEA_Mouse0.94321581
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94162515
135ESET_19884257_ChIP-Seq_ESCs_Mouse0.93860516
136MYB_26560356_Chip-Seq_TH2_Human0.93687364
137CTCF_26484167_Chip-Seq_Bcells_Mouse0.93568842
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.93489246
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92696765
140* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92445774
141* YY1_22570637_ChIP-Seq_MALME-3M_Human0.92264882
142TET1_21451524_ChIP-Seq_MESCs_Mouse0.91516189
143NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91210339
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90916056
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.90099853
146LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89541329
147NCOR1_26117541_ChIP-Seq_K562_Human0.88753441
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88548451
149BCAT_22108803_ChIP-Seq_LS180_Human0.88540974
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88445203
151TFEB_21752829_ChIP-Seq_HELA_Human0.88104519
152BCOR_27268052_Chip-Seq_Bcells_Human0.88096499
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87480779
154ERG_20517297_ChIP-Seq_VCAP_Human0.87416551
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86795702
156SOX2_21211035_ChIP-Seq_LN229_Human0.86641288
157RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86611718
158* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86443498
159FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86051489
160TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86036391
161MYB_26560356_Chip-Seq_TH1_Human0.85526796
162NANOG_20526341_ChIP-Seq_ESCs_Human0.83525558
163* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83154632
164TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82966851
165SOX11_22085726_ChIP-Seq_ESNs_Mouse0.82149696
166CTCF_20526341_ChIP-Seq_ESCs_Human0.82040477
167GATA3_26560356_Chip-Seq_TH1_Human0.81686401
168OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81486522
169SOX2_19829295_ChIP-Seq_ESCs_Human0.81462295
170NANOG_19829295_ChIP-Seq_ESCs_Human0.81462295
171* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81092311
172* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81017581
173TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80548731
174AR_25329375_ChIP-Seq_VCAP_Human0.79540876
175VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79300724
176SMRT_27268052_Chip-Seq_Bcells_Human0.79156408
177GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79086839
178ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78921920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.70088311
2MP0001929_abnormal_gametogenesis5.38410305
3MP0008877_abnormal_DNA_methylation5.32956383
4MP0008004_abnormal_stomach_pH3.92721456
5MP0005058_abnormal_lysosome_morphology3.75315347
6MP0002210_abnormal_sex_determination3.70244749
7MP0003724_increased_susceptibility_to3.35474839
8MP0003136_yellow_coat_color3.27188544
9MP0002161_abnormal_fertility/fecundity3.12388497
10MP0001145_abnormal_male_reproductive3.06265981
11MP0002148_abnormal_hypersensitivity_rea2.90960912
12MP0000372_irregular_coat_pigmentation2.69407183
13MP0000653_abnormal_sex_gland2.63532064
14MP0000343_altered_response_to2.59536838
15MP0002653_abnormal_ependyma_morphology2.47535179
16MP0009840_abnormal_foam_cell2.42432132
17MP0002139_abnormal_hepatobiliary_system2.14910480
18MP0005670_abnormal_white_adipose2.14301291
19MP0005410_abnormal_fertilization14.7900429
20MP0005171_absent_coat_pigmentation1.90294132
21MP0003172_abnormal_lysosome_physiology1.88749550
22MP0008057_abnormal_DNA_replication1.85625158
23MP0005167_abnormal_blood-brain_barrier1.81547881
24MP0005451_abnormal_body_composition1.70683116
25MP0002160_abnormal_reproductive_system1.64608768
26MP0005623_abnormal_meninges_morphology1.63437399
27MP0010094_abnormal_chromosome_stability1.62291977
28MP0002877_abnormal_melanocyte_morpholog1.60084173
29MP0008058_abnormal_DNA_repair1.57914793
30MP0010155_abnormal_intestine_physiology1.53013054
31MP0001533_abnormal_skeleton_physiology1.50884141
32MP0005310_abnormal_salivary_gland1.50439897
33MP0009764_decreased_sensitivity_to1.49253275
34MP0003656_abnormal_erythrocyte_physiolo1.43915560
35MP0003879_abnormal_hair_cell1.42694225
36MP0002998_abnormal_bone_remodeling1.40018442
37MP0005257_abnormal_intraocular_pressure1.31936680
38MP0003806_abnormal_nucleotide_metabolis1.31421676
39MP0001845_abnormal_inflammatory_respons1.29958948
40MP0004381_abnormal_hair_follicle1.29462549
41MP0000015_abnormal_ear_pigmentation1.27261227
42MP0003646_muscle_fatigue1.25001524
43MP0003183_abnormal_peptide_metabolism1.23588503
44MP0008995_early_reproductive_senescence1.22898686
45MP0000230_abnormal_systemic_arterial1.22338223
46MP0000371_diluted_coat_color1.20035140
47MP0005408_hypopigmentation1.16015739
48MP0009763_increased_sensitivity_to1.13856951
49MP0004233_abnormal_muscle_weight1.12212207
50MP0009278_abnormal_bone_marrow1.10014031
51MP0006054_spinal_hemorrhage1.08410470
52MP0004808_abnormal_hematopoietic_stem1.07397026
53MP0002090_abnormal_vision1.07215305
54MP0003786_premature_aging1.06735787
55MP0003111_abnormal_nucleus_morphology1.02405844
56MP0002282_abnormal_trachea_morphology1.02361606
57MP0003453_abnormal_keratinocyte_physiol1.00299117
58MP0003075_altered_response_to0.99156439
59MP0008469_abnormal_protein_level0.99008104
60MP0005647_abnormal_sex_gland0.98634602
61MP0003329_amyloid_beta_deposits0.97992510
62MP0009765_abnormal_xenobiotic_induced0.96978071
63MP0001545_abnormal_hematopoietic_system0.94312513
64MP0005397_hematopoietic_system_phenotyp0.94312513
65MP0008007_abnormal_cellular_replicative0.94225473
66MP0002405_respiratory_system_inflammati0.92447398
67MP0000465_gastrointestinal_hemorrhage0.91218879
68MP0001984_abnormal_olfaction0.89233475
69MP0002132_abnormal_respiratory_system0.88828257
70MP0003638_abnormal_response/metabolism_0.87512019
71MP0005389_reproductive_system_phenotype0.87432988
72MP0003191_abnormal_cellular_cholesterol0.85418020
73MP0005646_abnormal_pituitary_gland0.84993321
74MP0010307_abnormal_tumor_latency0.84819577
75MP0004130_abnormal_muscle_cell0.81114410
76MP0003763_abnormal_thymus_physiology0.80533311
77MP0000569_abnormal_digit_pigmentation0.79728178
78MP0002234_abnormal_pharynx_morphology0.78137835
79MP0000685_abnormal_immune_system0.77800429
80MP0001663_abnormal_digestive_system0.77157633
81MP0003077_abnormal_cell_cycle0.74559296
82MP0000249_abnormal_blood_vessel0.72481543
83MP0001765_abnormal_ion_homeostasis0.72331574
84MP0009780_abnormal_chondrocyte_physiolo0.70593464
85MP0001853_heart_inflammation0.70256150
86MP0008874_decreased_physiological_sensi0.69960500
87MP0005365_abnormal_bile_salt0.69953082
88MP0000358_abnormal_cell_content/0.69951976
89MP0003436_decreased_susceptibility_to0.69524179
90MP0005535_abnormal_body_temperature0.69144717
91MP0003828_pulmonary_edema0.69031156
92MP0002075_abnormal_coat/hair_pigmentati0.68158080
93MP0010329_abnormal_lipoprotein_level0.67750843
94MP0003115_abnormal_respiratory_system0.66902666
95MP0002398_abnormal_bone_marrow0.66354654
96MP0000858_altered_metastatic_potential0.65941379
97MP0003690_abnormal_glial_cell0.64340992
98MP0001800_abnormal_humoral_immune0.63761323
99MP0001730_embryonic_growth_arrest0.63753851
100MP0001727_abnormal_embryo_implantation0.62599972
101MP0003011_delayed_dark_adaptation0.62306433
102MP0002723_abnormal_immune_serum0.62116088
103MP0000703_abnormal_thymus_morphology0.60415871
104MP0003303_peritoneal_inflammation0.56828948
105MP0003693_abnormal_embryo_hatching0.56643805
106MP0004510_myositis0.54365116
107MP0002452_abnormal_antigen_presenting0.54333914
108MP0001835_abnormal_antigen_presentation0.53402014
109MP0002420_abnormal_adaptive_immunity0.52722940
110MP0003300_gastrointestinal_ulcer0.52557573
111MP0003699_abnormal_female_reproductive0.51729839
112MP0000313_abnormal_cell_death0.51714698
113MP0005076_abnormal_cell_differentiation0.51676543
114MP0001819_abnormal_immune_cell0.51052080
115MP0008961_abnormal_basal_metabolism0.50412868
116MP0000689_abnormal_spleen_morphology0.50389334
117MP0005387_immune_system_phenotype0.49848614
118MP0001790_abnormal_immune_system0.49848614
119MP0006082_CNS_inflammation0.49476441
120MP0005000_abnormal_immune_tolerance0.48101259
121MP0003878_abnormal_ear_physiology0.47597877
122MP0005377_hearing/vestibular/ear_phenot0.47597877
123MP0000716_abnormal_immune_system0.47593155
124MP0001851_eye_inflammation0.46959835
125MP0003448_altered_tumor_morphology0.46639244
126MP0005666_abnormal_adipose_tissue0.46511414
127MP0005671_abnormal_response_to0.46430353
128MP0005025_abnormal_response_to0.46135513
129MP0002928_abnormal_bile_duct0.46082056
130MP0001119_abnormal_female_reproductive0.45934450
131MP0001293_anophthalmia0.44411323
132MP0002722_abnormal_immune_system0.44043280
133MP0009785_altered_susceptibility_to0.43214413
134MP0004957_abnormal_blastocyst_morpholog0.43012463
135MP0009115_abnormal_fat_cell0.42535136
136MP0005464_abnormal_platelet_physiology0.41161654
137MP0002429_abnormal_blood_cell0.40985310
138MP0004947_skin_inflammation0.40183314
139MP0000604_amyloidosis0.40030921
140MP0001873_stomach_inflammation0.39707518
141MP0009333_abnormal_splenocyte_physiolog0.39076868
142MP0009046_muscle_twitch0.35643947
143MP0003045_fibrosis0.33429898
144MP0002019_abnormal_tumor_incidence0.33026727
145MP0005391_vision/eye_phenotype0.32471465
146MP0002419_abnormal_innate_immunity0.32198754
147MP0001324_abnormal_eye_pigmentation0.31589656
148MP0001697_abnormal_embryo_size0.31083975
149MP0005380_embryogenesis_phenotype0.29856117
150MP0001672_abnormal_embryogenesis/_devel0.29856117
151MP0002092_abnormal_eye_morphology0.29159101
152MP0004197_abnormal_fetal_growth/weight/0.28930994
153MP0005636_abnormal_mineral_homeostasis0.28645386
154MP0004036_abnormal_muscle_relaxation0.28526456
155MP0005253_abnormal_eye_physiology0.28452390
156MP0005551_abnormal_eye_electrophysiolog0.27563682

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.92536120
2Abnormal respiratory epithelium morphology (HP:0012253)8.68929529
3Abnormal respiratory motile cilium morphology (HP:0005938)8.68929529
4Rhinitis (HP:0012384)7.63433400
5Chronic bronchitis (HP:0004469)7.03841947
6Nasal polyposis (HP:0100582)6.97974518
7Abnormal ciliary motility (HP:0012262)6.88631980
8Infertility (HP:0000789)6.69373918
9Prolonged bleeding time (HP:0003010)6.02620499
10Petechiae (HP:0000967)5.91927507
11Purpura (HP:0000979)5.82017501
12Abnormality of the nasal mucosa (HP:0000433)5.69435363
13Abnormality of glycolipid metabolism (HP:0010969)5.55588347
14Abnormality of liposaccharide metabolism (HP:0010968)5.55588347
15Abnormality of glycosphingolipid metabolism (HP:0004343)5.55588347
16Bronchitis (HP:0012387)4.86588045
17Bronchiectasis (HP:0002110)4.75084684
18Menorrhagia (HP:0000132)4.64477083
19Increased mean platelet volume (HP:0011877)4.64208938
20Increased cerebral lipofuscin (HP:0011813)4.62469371
21Epistaxis (HP:0000421)4.48404812
22Abnormal platelet volume (HP:0011876)4.35510513
23Abnormality of macrophages (HP:0004311)4.33945562
24Nephronophthisis (HP:0000090)4.30789894
25Increased neuronal autofluorescent lipopigment (HP:0002074)4.07205117
26Male infertility (HP:0003251)3.95769486
27Gingival bleeding (HP:0000225)3.87170304
28Recurrent otitis media (HP:0000403)3.56748940
29Recurrent sinusitis (HP:0011108)3.55500866
30Impaired platelet aggregation (HP:0003540)3.54327019
31Abnormal platelet function (HP:0011869)3.54327019
32Abnormal spermatogenesis (HP:0008669)3.48130928
33Spontaneous abortion (HP:0005268)3.45061535
34Recurrent bronchitis (HP:0002837)3.41752111
35Vacuolated lymphocytes (HP:0001922)3.29572697
36Spontaneous hematomas (HP:0007420)3.27061993
37Stomatitis (HP:0010280)3.24940502
38Dysostosis multiplex (HP:0000943)3.24751259
39Abnormality of the renal medulla (HP:0100957)3.22603068
40Hyperlipoproteinemia (HP:0010980)3.18535222
41Gonadotropin excess (HP:0000837)3.15606647
42Hypoplasia of the fovea (HP:0007750)3.09339646
43Aplasia/Hypoplasia of the fovea (HP:0008060)3.09339646
44Abnormality of the lower motor neuron (HP:0002366)3.05123503
45Myocardial infarction (HP:0001658)3.01182014
46Abnormality of the vasculature of the conjunctiva (HP:0008054)2.99898029
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.82736411
48Xanthomatosis (HP:0000991)2.79622883
49Abnormality of lateral ventricle (HP:0030047)2.77400680
50Paralysis (HP:0003470)2.69682904
51Nausea (HP:0002018)2.69316891
52Impulsivity (HP:0100710)2.67106508
53Hepatosplenomegaly (HP:0001433)2.66810955
54Eczematoid dermatitis (HP:0000976)2.66177867
55Increased IgM level (HP:0003496)2.63866307
56Keratoconjunctivitis sicca (HP:0001097)2.62470755
57Tubulointerstitial nephritis (HP:0001970)2.60381914
58Amyotrophic lateral sclerosis (HP:0007354)2.57481970
59Keratoconjunctivitis (HP:0001096)2.53583901
60Disinhibition (HP:0000734)2.50834574
61Azoospermia (HP:0000027)2.49616028
62Recurrent bacterial skin infections (HP:0005406)2.49589892
63Abnormality of the fovea (HP:0000493)2.49356290
64Autoimmune thrombocytopenia (HP:0001973)2.47094556
65Tubular atrophy (HP:0000092)2.47011826
66Generalized aminoaciduria (HP:0002909)2.45817562
67Increased serum ferritin (HP:0003281)2.44404327
68Abnormality of midbrain morphology (HP:0002418)2.33457956
69Molar tooth sign on MRI (HP:0002419)2.33457956
70Recurrent abscess formation (HP:0002722)2.31623732
71Poikilocytosis (HP:0004447)2.31573045
72Fibular hypoplasia (HP:0003038)2.31139907
73Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31070832
74Tubulointerstitial abnormality (HP:0001969)2.29241870
75Joint swelling (HP:0001386)2.28844419
76Upper limb muscle weakness (HP:0003484)2.26395483
77Abnormality of iron homeostasis (HP:0011031)2.21300461
78Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19050857
79Neurofibrillary tangles (HP:0002185)2.17015369
80Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16980894
81Aplasia/Hypoplasia of the macula (HP:0008059)2.15611914
82Albinism (HP:0001022)2.13652187
83Cholecystitis (HP:0001082)2.13231494
84Abnormal gallbladder physiology (HP:0012438)2.13231494
85Abnormality of transition element cation homeostasis (HP:0011030)2.12023110
86Systemic lupus erythematosus (HP:0002725)2.12022725
87Mutism (HP:0002300)2.11989028
88Autoimmune hemolytic anemia (HP:0001890)2.08792754
89Postaxial foot polydactyly (HP:0001830)2.08273186
90Gangrene (HP:0100758)2.06935635
91Medial flaring of the eyebrow (HP:0010747)2.06758128
92Impaired proprioception (HP:0010831)2.06734331
93Arterial thrombosis (HP:0004420)2.06210990
94Increased density of long bones (HP:0006392)2.05854650
95Encephalitis (HP:0002383)2.05129168
96Obstructive lung disease (HP:0006536)2.00436490
97Chronic obstructive pulmonary disease (HP:0006510)2.00436490
98Basal ganglia calcification (HP:0002135)2.00045607
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8109793
100Absent/shortened dynein arms (HP:0200106)12.4244670
101Dynein arm defect of respiratory motile cilia (HP:0012255)12.4244670
102Acanthocytosis (HP:0001927)1.98026086
103Tinnitus (HP:0000360)1.97512078
104Metaphyseal irregularity (HP:0003025)1.97133152
105Bruising susceptibility (HP:0000978)1.96632446
106Myositis (HP:0100614)1.95762634
107Upper motor neuron abnormality (HP:0002127)1.95595372
108Aplasia/Hypoplasia affecting the retina (HP:0008061)1.95479601
109Amaurosis fugax (HP:0100576)1.93863216
110Prolonged neonatal jaundice (HP:0006579)1.93608029
111Recurrent gram-negative bacterial infections (HP:0005420)1.90779612
112Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90423315
113Abnormality of polysaccharide metabolism (HP:0011012)1.90423315
114Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90423315
115Congenital sensorineural hearing impairment (HP:0008527)1.89849945
116Heterotopia (HP:0002282)1.89660634
117Short ribs (HP:0000773)1.88740960
118Progressive neurologic deterioration (HP:0002344)1.88627375
119Congenital hepatic fibrosis (HP:0002612)1.87407492
120Chronic sinusitis (HP:0011109)1.87088247
121Tubulointerstitial fibrosis (HP:0005576)1.86951772
1223-Methylglutaconic aciduria (HP:0003535)1.86203841
123Abnormal auditory evoked potentials (HP:0006958)1.85938126
124Spastic tetraparesis (HP:0001285)1.84404316
125Stage 5 chronic kidney disease (HP:0003774)1.84377847
126Flat occiput (HP:0005469)1.82934872
127Polyneuropathy (HP:0001271)1.82143886
128Ventricular fibrillation (HP:0001663)1.80741211
129Cerebral inclusion bodies (HP:0100314)1.79771550
130Abnormal pupillary function (HP:0007686)1.79141580
131Blue irides (HP:0000635)1.78509297
132Severe visual impairment (HP:0001141)1.78144292
133Urinary glycosaminoglycan excretion (HP:0003541)1.77973349
134Mucopolysacchariduria (HP:0008155)1.77973349
135Degeneration of anterior horn cells (HP:0002398)1.77801296
136Abnormality of the anterior horn cell (HP:0006802)1.77801296
137Vertigo (HP:0002321)1.77774061
138Absent frontal sinuses (HP:0002688)1.76562793
139Polyphagia (HP:0002591)1.75693171
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68291608
141Absent epiphyses (HP:0010577)1.68291608
142Facial cleft (HP:0002006)1.63644211
143Oculomotor apraxia (HP:0000657)1.63364443
144Abnormality of the renal cortex (HP:0011035)1.62048931
145Choroideremia (HP:0001139)1.59225768
146Abnormal drinking behavior (HP:0030082)1.58000695
147Polydipsia (HP:0001959)1.58000695
148J-shaped sella turcica (HP:0002680)1.55836543
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54826067
150Dyschromatopsia (HP:0007641)1.52225015
151Deformed sella turcica (HP:0002681)1.51717040
152Broad distal phalanx of finger (HP:0009836)1.51040729
153Renal dysplasia (HP:0000110)1.47672996
15411 pairs of ribs (HP:0000878)1.47670802
155Loss of speech (HP:0002371)1.46687869
156Optic neuritis (HP:0100653)1.46065768
157Retrobulbar optic neuritis (HP:0100654)1.46065768
158Microglossia (HP:0000171)1.45387323
159Short thorax (HP:0010306)1.45125648
160Aplasia/Hypoplasia of the fibula (HP:0006492)1.42915228
161Abnormality of dentin (HP:0010299)1.42823945
162Hemiparesis (HP:0001269)1.41267510
163Postaxial hand polydactyly (HP:0001162)1.41077005
164Conjunctival telangiectasia (HP:0000524)1.39331629
165Decreased central vision (HP:0007663)1.38729700
166Abnormality of the dental root (HP:0006486)1.37965208
167Taurodontia (HP:0000679)1.37965208
168Abnormality of permanent molar morphology (HP:0011071)1.37965208
169Abnormality of ocular smooth pursuit (HP:0000617)1.35555415
170Abnormal biliary tract physiology (HP:0012439)1.32376251
171Bile duct proliferation (HP:0001408)1.32376251
172Abnormality of renal excretion (HP:0011036)1.31643988
173Median cleft lip (HP:0000161)1.31275254
174Short femoral neck (HP:0100864)1.30952541
175Bell-shaped thorax (HP:0001591)1.30735317
176Short nail (HP:0001799)1.30210387
177Supernumerary spleens (HP:0009799)1.29695306
178Nephropathy (HP:0000112)1.28069292
179Abnormality of molar morphology (HP:0011070)1.25837692
180Abnormality of molar (HP:0011077)1.25837692
181Selective tooth agenesis (HP:0001592)1.23513418
182Abnormality of the dental pulp (HP:0006479)1.23241520
183Truncal obesity (HP:0001956)1.21822381
184Orchitis (HP:0100796)1.21151590
185Sloping forehead (HP:0000340)1.21124191
186Aplasia/Hypoplasia of the tongue (HP:0010295)1.19519553
187Cerebellar dysplasia (HP:0007033)1.19025082
188Asymmetric septal hypertrophy (HP:0001670)1.18773411
189Easy fatigability (HP:0003388)1.17993486
190Cystic liver disease (HP:0006706)1.17686242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.07948271
2PDK48.07948271
3TESK15.80157731
4PDK25.15528439
5PRKD34.54948468
6IRAK34.16210458
7ICK4.12105998
8MST43.83190327
9ADRBK22.91795300
10ACVR1B2.65953684
11GRK72.59467625
12FGR2.45891874
13MATK2.38940425
14PTK2B2.38403212
15NEK22.36868749
16BMPR22.33944358
17TAOK22.25368399
18TAOK32.17544474
19FRK2.15568230
20PNCK2.09256931
21MAP3K32.08233535
22WNK41.94215811
23STK391.81960327
24BLK1.72168731
25PIK3CG1.64194871
26DDR21.59159501
27TEC1.53181196
28STK381.49920097
29EEF2K1.46038403
30NME21.41299208
31DYRK1B1.37913130
32MYLK1.32096985
33PLK21.26137290
34MAPKAPK31.23559035
35MAP3K51.21017721
36LYN1.20768664
37NEK91.13811289
38PDK11.10778630
39PASK1.07308807
40MAP4K11.07194900
41TESK21.04491985
42CDC71.03572116
43MAP3K111.00216896
44MAP2K30.98039130
45PIM20.97462085
46STK30.94567283
47IRAK40.92670628
48WNK10.88217451
49TYRO30.86530106
50CCNB10.81024499
51TTK0.80805357
52MAP3K10.79893693
53CDK120.77794234
54MAPK150.76584205
55JAK20.74613350
56MAP3K100.73877384
57PKN10.72882443
58DYRK30.72859302
59EPHA30.71775611
60STK100.70093097
61DAPK20.69634556
62CHEK10.60347873
63KIT0.59639289
64ATR0.59165729
65FER0.59162705
66MOS0.58597729
67CAMK1G0.57201429
68JAK10.57128594
69ZAP700.55422224
70TXK0.55198128
71CHEK20.54248422
72FES0.52019159
73MAP3K20.50957820
74RIPK40.50915971
75CDC42BPA0.50910101
76TRIB30.47614504
77ILK0.47421771
78TBK10.47127989
79ABL20.45949295
80IRAK20.45576562
81PDPK10.45513047
82DAPK30.45305922
83PAK20.44139612
84PRPF4B0.43315376
85ATM0.43102307
86PRKACG0.42218982
87PAK10.41747750
88BMPR1B0.41587147
89TNK20.41179883
90TNIK0.41037425
91LMTK20.40416813
92MTOR0.40179566
93CLK10.39649737
94RET0.38593562
95IRAK10.38241291
96RPS6KA40.37845703
97CSK0.36979725
98WEE10.33598450
99PRKD10.33516966
100TAOK10.32626871
101GRK50.32369126
102NTRK20.31952628
103MARK20.31519133
104PLK10.31478681
105PIM10.29660157
106ERBB20.28863478
107SGK30.28380191
108CSF1R0.28074657
109ADRBK10.27960773
110EPHB10.26690335
111CDK30.26272667
112CDK140.25682829
113MAPK120.25551351
114MAP3K140.24804947
115PAK60.24564949
116IGF1R0.24440170
117TYK20.24419123
118RPS6KB10.24166439
119MARK30.23608346
120PRKG10.23109352
121JAK30.21353744
122CAMKK10.21249513
123EIF2AK10.21020325
124ABL10.20987624
125PLK40.20704067
126PAK40.20478285
127CDK40.20008808
128ITK0.18292790
129LCK0.15180653
130BTK0.14331806
131RPS6KA10.13799325
132PKN20.13798979
133CHUK0.13580734
134EGFR0.13562272
135PRKCG0.13098725
136CDK20.12252512
137PRKAA10.12051073
138PRKCQ0.12040790
139IKBKE0.11590524
140CDK10.09801717
141HCK0.09554732
142CDK90.09547302
143CSNK2A10.09364411
144CDK60.09059902
145PINK10.08932246
146MAP2K60.08510935
147BUB10.07854397
148PDGFRB0.06992903
149BMX0.06082840
150CSNK1D0.05969625
151PTK60.05309436
152GSK3B0.04837867
153SYK0.04726127
154CDK150.04702835
155CSNK2A20.03379752
156MAPK80.03346439
157IKBKB0.03176737
158PRKDC0.02884002
159MAPK10.02341852
160CDK180.01902314
161PRKG20.01841472

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.97089453
2Vitamin B6 metabolism_Homo sapiens_hsa007503.97082367
3Fatty acid biosynthesis_Homo sapiens_hsa000613.68758635
4Pyruvate metabolism_Homo sapiens_hsa006203.15132586
5Basal transcription factors_Homo sapiens_hsa030222.85913207
6Lysosome_Homo sapiens_hsa041422.84051607
7Rheumatoid arthritis_Homo sapiens_hsa053232.66811498
8Dorso-ventral axis formation_Homo sapiens_hsa043202.58675347
9Platelet activation_Homo sapiens_hsa046112.54484052
10Glucagon signaling pathway_Homo sapiens_hsa049222.50485280
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.50171315
12Selenocompound metabolism_Homo sapiens_hsa004502.42282875
13Fanconi anemia pathway_Homo sapiens_hsa034602.28700048
14Pentose phosphate pathway_Homo sapiens_hsa000302.26688857
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24450434
16Linoleic acid metabolism_Homo sapiens_hsa005912.14680437
17SNARE interactions in vesicular transport_Homo sapiens_hsa041302.12958156
18Antigen processing and presentation_Homo sapiens_hsa046122.08499943
19Other glycan degradation_Homo sapiens_hsa005112.06083335
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96476417
21Hematopoietic cell lineage_Homo sapiens_hsa046401.90427075
22Staphylococcus aureus infection_Homo sapiens_hsa051501.87341414
23Oocyte meiosis_Homo sapiens_hsa041141.79067140
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.76905167
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.75949007
26Propanoate metabolism_Homo sapiens_hsa006401.75757286
27RNA transport_Homo sapiens_hsa030131.71409382
28TNF signaling pathway_Homo sapiens_hsa046681.70865753
29Leishmaniasis_Homo sapiens_hsa051401.70747400
30Chemokine signaling pathway_Homo sapiens_hsa040621.62686058
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61797965
32Glycerolipid metabolism_Homo sapiens_hsa005611.60030293
33Tuberculosis_Homo sapiens_hsa051521.58875770
34Autoimmune thyroid disease_Homo sapiens_hsa053201.57771249
35mRNA surveillance pathway_Homo sapiens_hsa030151.57032178
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.53922496
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51621355
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50986525
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.50837576
40Legionellosis_Homo sapiens_hsa051341.50239050
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44512635
42African trypanosomiasis_Homo sapiens_hsa051431.40937948
43Fructose and mannose metabolism_Homo sapiens_hsa000511.39454238
44Phagosome_Homo sapiens_hsa041451.36163037
45Pertussis_Homo sapiens_hsa051331.35471327
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35264854
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.33606287
48T cell receptor signaling pathway_Homo sapiens_hsa046601.29819913
49B cell receptor signaling pathway_Homo sapiens_hsa046621.29124413
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26294224
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21765606
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.20716763
53Renin secretion_Homo sapiens_hsa049241.17348428
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.16847825
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16775623
56Amphetamine addiction_Homo sapiens_hsa050311.16486846
57PPAR signaling pathway_Homo sapiens_hsa033201.13626259
58Mineral absorption_Homo sapiens_hsa049781.12254657
59Measles_Homo sapiens_hsa051621.10887389
60Olfactory transduction_Homo sapiens_hsa047401.05607839
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05069119
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01274665
63Carbon metabolism_Homo sapiens_hsa012000.97662309
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97144049
65Purine metabolism_Homo sapiens_hsa002300.95680650
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94088978
67Arachidonic acid metabolism_Homo sapiens_hsa005900.93375825
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92820359
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90480754
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.89914148
71VEGF signaling pathway_Homo sapiens_hsa043700.89803318
72Nitrogen metabolism_Homo sapiens_hsa009100.88799802
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.88246509
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.84737695
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84442697
76Sulfur metabolism_Homo sapiens_hsa009200.84134244
77Osteoclast differentiation_Homo sapiens_hsa043800.82906587
78Apoptosis_Homo sapiens_hsa042100.81811970
79Sphingolipid metabolism_Homo sapiens_hsa006000.80741823
80Biosynthesis of amino acids_Homo sapiens_hsa012300.79833219
81Graft-versus-host disease_Homo sapiens_hsa053320.77511677
82Ether lipid metabolism_Homo sapiens_hsa005650.76937443
83Huntingtons disease_Homo sapiens_hsa050160.76684258
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74389970
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72961381
86Viral carcinogenesis_Homo sapiens_hsa052030.70799102
87Epstein-Barr virus infection_Homo sapiens_hsa051690.70097694
88Fat digestion and absorption_Homo sapiens_hsa049750.69493556
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68061835
90Amoebiasis_Homo sapiens_hsa051460.67021629
91DNA replication_Homo sapiens_hsa030300.66422452
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.66374859
93Cardiac muscle contraction_Homo sapiens_hsa042600.66354866
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65490098
95Tryptophan metabolism_Homo sapiens_hsa003800.65361638
96Cell cycle_Homo sapiens_hsa041100.65106270
97Toxoplasmosis_Homo sapiens_hsa051450.64996624
98Influenza A_Homo sapiens_hsa051640.64189763
99Estrogen signaling pathway_Homo sapiens_hsa049150.63289391
100Long-term potentiation_Homo sapiens_hsa047200.62905711
101Endocytosis_Homo sapiens_hsa041440.62199671
102Viral myocarditis_Homo sapiens_hsa054160.61675634
103Herpes simplex infection_Homo sapiens_hsa051680.61523021
104Allograft rejection_Homo sapiens_hsa053300.60386228
105Fatty acid metabolism_Homo sapiens_hsa012120.58434205
106HTLV-I infection_Homo sapiens_hsa051660.58283001
107Homologous recombination_Homo sapiens_hsa034400.57999871
108Non-homologous end-joining_Homo sapiens_hsa034500.57770388
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55904012
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53283440
111Primary immunodeficiency_Homo sapiens_hsa053400.52120408
112RNA degradation_Homo sapiens_hsa030180.51366002
113Type II diabetes mellitus_Homo sapiens_hsa049300.51091041
114Complement and coagulation cascades_Homo sapiens_hsa046100.50450592
115Salmonella infection_Homo sapiens_hsa051320.49176626
116Systemic lupus erythematosus_Homo sapiens_hsa053220.48890126
117Hepatitis B_Homo sapiens_hsa051610.47740145
118Pyrimidine metabolism_Homo sapiens_hsa002400.46531200
119Hepatitis C_Homo sapiens_hsa051600.45703871
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45153258
121Serotonergic synapse_Homo sapiens_hsa047260.44471412
122HIF-1 signaling pathway_Homo sapiens_hsa040660.44153723
123Renin-angiotensin system_Homo sapiens_hsa046140.43545960
124Asthma_Homo sapiens_hsa053100.42236496
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.41026838
126Spliceosome_Homo sapiens_hsa030400.40082827
127Vibrio cholerae infection_Homo sapiens_hsa051100.39768621
128Prion diseases_Homo sapiens_hsa050200.37901948
129Steroid biosynthesis_Homo sapiens_hsa001000.37884674
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37842648
131Inositol phosphate metabolism_Homo sapiens_hsa005620.37392395
132ABC transporters_Homo sapiens_hsa020100.36842743
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36736952
134Fatty acid degradation_Homo sapiens_hsa000710.36246440
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35925486
136AMPK signaling pathway_Homo sapiens_hsa041520.35068950
137Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34840492
138Malaria_Homo sapiens_hsa051440.34425035
139Calcium signaling pathway_Homo sapiens_hsa040200.34236798
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34159190
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34144256
142Shigellosis_Homo sapiens_hsa051310.33766188
143Pancreatic secretion_Homo sapiens_hsa049720.33218517
144Synaptic vesicle cycle_Homo sapiens_hsa047210.33015202
145Acute myeloid leukemia_Homo sapiens_hsa052210.32980804
146Gap junction_Homo sapiens_hsa045400.32794573
147Type I diabetes mellitus_Homo sapiens_hsa049400.30889501
148Insulin resistance_Homo sapiens_hsa049310.29266335
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.29031867
150Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28490508
151Base excision repair_Homo sapiens_hsa034100.27540862
152Collecting duct acid secretion_Homo sapiens_hsa049660.27516910
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.23550029
154p53 signaling pathway_Homo sapiens_hsa041150.23166688
155Glutathione metabolism_Homo sapiens_hsa004800.22600141

Most similar genes based on co-expression Upload to Enrichr

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