ENTPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)6.94385323
2macrophage activation involved in immune response (GO:0002281)5.83923709
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.72399798
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.72399798
5modulation by symbiont of host immune response (GO:0052553)5.72399798
6positive regulation by symbiont of host defense response (GO:0052509)5.72399798
7modulation by symbiont of host defense response (GO:0052031)5.72399798
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.72399798
9G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.69961374
10regulation of interferon-beta biosynthetic process (GO:0045357)5.27398905
11cytidine deamination (GO:0009972)5.24858431
12cytidine metabolic process (GO:0046087)5.24858431
13cytidine catabolic process (GO:0006216)5.24858431
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.05077361
15B cell receptor signaling pathway (GO:0050853)4.87469753
16T cell migration (GO:0072678)4.75355625
17pyrimidine ribonucleoside catabolic process (GO:0046133)4.72483863
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60636237
19negative regulation of cell killing (GO:0031342)4.60636237
20macrophage activation (GO:0042116)4.60175441
21antigen processing and presentation of endogenous antigen (GO:0019883)4.59171925
22cellular response to interleukin-15 (GO:0071350)4.53859970
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45596250
24positive regulation of chemokine secretion (GO:0090197)4.39917584
25regulation of gamma-delta T cell activation (GO:0046643)4.38276954
26regulation of B cell receptor signaling pathway (GO:0050855)4.33749597
27response to interleukin-15 (GO:0070672)4.33292537
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23454711
29cellular extravasation (GO:0045123)4.16735635
30B cell mediated immunity (GO:0019724)4.11734633
31DNA deamination (GO:0045006)4.05308862
32interferon-gamma-mediated signaling pathway (GO:0060333)4.05290179
33positive thymic T cell selection (GO:0045059)4.03609625
34negative thymic T cell selection (GO:0045060)4.00099705
35regulation of alpha-beta T cell proliferation (GO:0046640)3.96987155
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.94990340
37positive regulation of interferon-alpha production (GO:0032727)3.90001726
38CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.89971175
39purinergic nucleotide receptor signaling pathway (GO:0035590)3.89684076
40neutrophil activation involved in immune response (GO:0002283)3.86419109
41regulation of interferon-alpha production (GO:0032647)3.85247742
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.84834376
43G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.84652597
44negative T cell selection (GO:0043383)3.84582430
45regulation of B cell differentiation (GO:0045577)3.80272920
46negative regulation of interleukin-12 production (GO:0032695)3.79304323
47detection of other organism (GO:0098543)3.78290730
48positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.73434783
49detection of bacterium (GO:0016045)3.70242156
50regulation of gamma-delta T cell differentiation (GO:0045586)3.67787110
51response to type I interferon (GO:0034340)3.66573210
52regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.65548160
53cellular response to type I interferon (GO:0071357)3.65437186
54type I interferon signaling pathway (GO:0060337)3.65437186
55glycosphingolipid catabolic process (GO:0046479)3.64344499
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.60814464
57response to host (GO:0075136)3.60814464
58response to host defenses (GO:0052200)3.60814464
59B cell homeostasis (GO:0001782)3.58404883
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.58008305
61glycolipid catabolic process (GO:0019377)3.57933757
62myeloid cell activation involved in immune response (GO:0002275)3.57648584
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.55019614
64response to host immune response (GO:0052572)3.55019614
65T-helper 1 type immune response (GO:0042088)3.53858851
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.51239735
67negative regulation of granulocyte differentiation (GO:0030853)3.48290045
68oligosaccharide catabolic process (GO:0009313)3.46332673
69adenosine receptor signaling pathway (GO:0001973)3.44506057
70response to muramyl dipeptide (GO:0032495)3.43152572
71regulation of chemokine secretion (GO:0090196)3.41901594
72detection of external biotic stimulus (GO:0098581)3.41719648
73I-kappaB phosphorylation (GO:0007252)3.40959623
74positive regulation of antigen processing and presentation (GO:0002579)3.39201947
75regulation of mast cell degranulation (GO:0043304)3.39036055
76positive regulation of alpha-beta T cell proliferation (GO:0046641)3.37635026
77T cell costimulation (GO:0031295)3.35767399
78positive T cell selection (GO:0043368)3.34067080
79negative regulation of T cell mediated immunity (GO:0002710)3.32460603
80lymphocyte costimulation (GO:0031294)3.31280651
81response to peptidoglycan (GO:0032494)3.29733143
82regulation of mast cell activation involved in immune response (GO:0033006)3.25563774
83keratan sulfate catabolic process (GO:0042340)3.24143879
84negative regulation of mast cell activation (GO:0033004)3.23196736
85respiratory burst (GO:0045730)3.22802056
86ceramide catabolic process (GO:0046514)3.22665269
87negative regulation of systemic arterial blood pressure (GO:0003085)3.21875172
88immunoglobulin mediated immune response (GO:0016064)3.21590835
89adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.20651480
90cellular response to interferon-gamma (GO:0071346)3.19118683
91regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18784135
92positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.17981826
93thymic T cell selection (GO:0045061)3.17865932
94antigen receptor-mediated signaling pathway (GO:0050851)3.17006168
95defense response to protozoan (GO:0042832)3.16970936
96lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15994088
97regulation of B cell proliferation (GO:0030888)3.15690880
98response to laminar fluid shear stress (GO:0034616)3.14964378
99purinergic receptor signaling pathway (GO:0035587)3.12503718
100positive regulation of defense response to virus by host (GO:0002230)3.10673075
101negative regulation of lymphocyte mediated immunity (GO:0002707)3.09204864
102hyaluronan catabolic process (GO:0030214)3.07404110
103angiogenesis involved in wound healing (GO:0060055)3.06496551
104T cell selection (GO:0045058)3.06342641
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.05797929
106regulation of natural killer cell mediated immunity (GO:0002715)3.05797929
107positive regulation of humoral immune response (GO:0002922)3.03778445
108regulation of regulatory T cell differentiation (GO:0045589)3.03127211
109positive regulation of B cell differentiation (GO:0045579)3.03122533
110interferon-gamma production (GO:0032609)3.02624067
111regulation of interleukin-12 biosynthetic process (GO:0045075)3.01064522
112regulation of T cell tolerance induction (GO:0002664)3.00380349
113negative regulation of alpha-beta T cell activation (GO:0046636)3.00202613
114regulation of interleukin-2 biosynthetic process (GO:0045076)2.99767642
115granulocyte activation (GO:0036230)2.97702815
116detection of biotic stimulus (GO:0009595)2.97590636
117neutrophil activation (GO:0042119)2.96717806
118surfactant homeostasis (GO:0043129)2.93526843
119positive regulation of vasculogenesis (GO:2001214)2.93272107
120negative regulation of leukocyte mediated immunity (GO:0002704)2.92963962
121myeloid dendritic cell activation (GO:0001773)2.92635710
122regulation of mast cell activation (GO:0033003)2.92477030
123histamine secretion (GO:0001821)2.91768792
124myeloid leukocyte activation (GO:0002274)2.87351555
125negative regulation of interleukin-6 production (GO:0032715)2.87317079
126phagocytosis, engulfment (GO:0006911)2.85417111
127apoptotic cell clearance (GO:0043277)2.82842479
128negative regulation of B cell proliferation (GO:0030889)2.82739067
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82683325
130positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82350958
131germinal center formation (GO:0002467)2.80900809
132blood vessel maturation (GO:0001955)2.80229211
133chondroitin sulfate catabolic process (GO:0030207)2.79609133
134endothelium development (GO:0003158)2.79367571
135regulation of antigen processing and presentation (GO:0002577)2.79091344
136regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77022974
137regulation of leukocyte degranulation (GO:0043300)2.74909978
138mannose metabolic process (GO:0006013)2.74855389
139positive regulation of monocyte chemotaxis (GO:0090026)2.74294487
140regulation of interleukin-8 biosynthetic process (GO:0045414)2.74135588
141lymph vessel development (GO:0001945)2.73489747
142regulation of endothelial cell differentiation (GO:0045601)2.72886541
143positive regulation of toll-like receptor signaling pathway (GO:0034123)2.71992788
144protein kinase C signaling (GO:0070528)2.71067126
145monocyte differentiation (GO:0030224)2.69598896
146regulation of monocyte chemotaxis (GO:0090025)2.68760967
147macrophage chemotaxis (GO:0048246)2.67179660
148positive regulation of interferon-beta production (GO:0032728)2.65841386
149ruffle organization (GO:0031529)2.65765828
150response to interferon-beta (GO:0035456)2.64733412
151positive regulation of gamma-delta T cell activation (GO:0046645)2.64489184
152detection of molecule of bacterial origin (GO:0032490)2.60642166
153adaptation of signaling pathway (GO:0023058)2.59451964
154regulation of macrophage chemotaxis (GO:0010758)2.58255304
155positive regulation of cellular amide metabolic process (GO:0034250)2.57514881
156macrophage differentiation (GO:0030225)2.57462348
157neutrophil chemotaxis (GO:0030593)2.56200564
158retina vasculature morphogenesis in camera-type eye (GO:0061299)2.55057619
159leukocyte tethering or rolling (GO:0050901)2.53911776
160negative regulation of norepinephrine secretion (GO:0010700)2.53824545
161regulation of platelet activation (GO:0010543)2.51489099
162positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.51023892
163positive regulation of smooth muscle cell migration (GO:0014911)2.50233680
164regulation of chemokine-mediated signaling pathway (GO:0070099)2.49749315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.45823728
2* IRF8_21731497_ChIP-ChIP_J774_Mouse5.53070402
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.48471674
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.31030255
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.04439305
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.02755818
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15984905
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15261703
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.10539005
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94058798
11* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.89545206
12* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.77573738
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.74140382
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65874351
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.57887818
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42800890
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36758472
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.36446296
19RUNX_20019798_ChIP-Seq_JUKART_Human2.19912933
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18001039
21* SCL_19346495_ChIP-Seq_HPC-7_Human2.16319397
22SPI1_23127762_ChIP-Seq_K562_Human2.08215440
23* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04623298
24VDR_24787735_ChIP-Seq_THP-1_Human2.04103313
25SPI1_23547873_ChIP-Seq_NB4_Human1.93740680
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91190015
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87626759
28* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86497715
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85476553
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73390487
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73147726
32VDR_24763502_ChIP-Seq_THP-1_Human1.71625638
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70140166
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67514852
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67328414
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.63771875
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63635570
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62644843
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60764516
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56566809
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.53553876
42MAF_26560356_Chip-Seq_TH1_Human1.48733587
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48288532
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48234524
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.48109350
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.47907128
47GATA1_22025678_ChIP-Seq_K562_Human1.46657761
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.46354714
49MYC_22102868_ChIP-Seq_BL_Human1.43516823
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39455647
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.39010537
52PU_27001747_Chip-Seq_BMDM_Mouse1.37565806
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.35940948
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35194417
55EGR1_19032775_ChIP-ChIP_M12_Human1.34886912
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34592299
57MYB_26560356_Chip-Seq_TH2_Human1.34436340
58SMRT_27268052_Chip-Seq_Bcells_Human1.32481727
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.32434909
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31441198
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29410121
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29303047
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29303047
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29303047
65MYB_26560356_Chip-Seq_TH1_Human1.25425880
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23842276
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.21522170
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21367367
69CIITA_25753668_ChIP-Seq_RAJI_Human1.20872580
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19628338
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17870948
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15917242
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14636277
74MAF_26560356_Chip-Seq_TH2_Human1.13701566
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13337990
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12575248
77UTX_26944678_Chip-Seq_JUKART_Human1.12043801
78VDR_21846776_ChIP-Seq_THP-1_Human1.11763795
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.10532735
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10121714
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09783102
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09674376
83* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09329396
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.08204716
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07532442
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07422712
87SOX2_20726797_ChIP-Seq_SW620_Human1.06558756
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04784108
89* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04356901
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04311607
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.04278446
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03677349
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03046013
94TCF7_22412390_ChIP-Seq_EML_Mouse1.02572251
95GATA3_27048872_Chip-Seq_THYMUS_Human1.02305368
96IRF1_19129219_ChIP-ChIP_H3396_Human1.02046682
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01957249
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.99654448
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99360319
100GATA1_19941826_ChIP-Seq_K562_Human0.97658125
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96942670
102GATA3_26560356_Chip-Seq_TH1_Human0.96910380
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96074745
104GATA2_19941826_ChIP-Seq_K562_Human0.95956954
105GATA3_26560356_Chip-Seq_TH2_Human0.95952878
106GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95882356
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95063319
108CJUN_26792858_Chip-Seq_BT549_Human0.94374677
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94253154
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93516008
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92544180
112CLOCK_20551151_ChIP-Seq_293T_Human0.92330977
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92207305
114WT1_19549856_ChIP-ChIP_CCG9911_Human0.91055567
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90776634
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90368680
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.88891099
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88673282
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88614867
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88614867
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88491597
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87660730
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.87282907
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87268287
125TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85307109
126ZNF274_21170338_ChIP-Seq_K562_Hela0.83684249
127GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80554782
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79681658
129AR_21572438_ChIP-Seq_LNCaP_Human0.79546283
130BCAT_22108803_ChIP-Seq_LS180_Human0.74813555
131TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74786069
132ER_23166858_ChIP-Seq_MCF-7_Human0.73978284
133FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73596052
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73556280
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.73187516
136OCT4_21477851_ChIP-Seq_ESCs_Mouse0.72972447
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72241008
138RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71260509
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.71118604
140FOXA1_21572438_ChIP-Seq_LNCaP_Human0.70709095
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.69252266
142* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68172579
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66196187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.96307535
2MP0003724_increased_susceptibility_to3.74923757
3MP0006082_CNS_inflammation3.71155127
4MP0003191_abnormal_cellular_cholesterol3.56139860
5MP0003303_peritoneal_inflammation3.35128064
6MP0001835_abnormal_antigen_presentation3.33699161
7MP0003172_abnormal_lysosome_physiology2.81221522
8MP0003763_abnormal_thymus_physiology2.67320545
9* MP0002419_abnormal_innate_immunity2.61711288
10MP0005671_abnormal_response_to2.58775793
11MP0003436_decreased_susceptibility_to2.54984626
12MP0010368_abnormal_lymphatic_system2.50044587
13MP0005167_abnormal_blood-brain_barrier2.38839573
14MP0003690_abnormal_glial_cell2.32592369
15MP0000569_abnormal_digit_pigmentation2.31729463
16MP0009785_altered_susceptibility_to2.28016116
17MP0000343_altered_response_to2.24571371
18MP0002148_abnormal_hypersensitivity_rea2.23446107
19* MP0005464_abnormal_platelet_physiology2.19953647
20MP0001879_abnormal_lymphatic_vessel2.18921861
21MP0005000_abnormal_immune_tolerance2.18475294
22MP0002452_abnormal_antigen_presenting2.16033126
23MP0002138_abnormal_hepatobiliary_system2.07172711
24MP0001851_eye_inflammation2.03408146
25MP0005025_abnormal_response_to1.99948099
26MP0008004_abnormal_stomach_pH1.95842258
27MP0001800_abnormal_humoral_immune1.93762261
28MP0006054_spinal_hemorrhage1.93274590
29MP0003828_pulmonary_edema1.92301895
30MP0004883_abnormal_blood_vessel1.92267125
31MP0002723_abnormal_immune_serum1.91460571
32MP0001533_abnormal_skeleton_physiology1.90567348
33MP0003300_gastrointestinal_ulcer1.88378966
34MP0001986_abnormal_taste_sensitivity1.81460570
35* MP0001819_abnormal_immune_cell1.75360555
36* MP0002420_abnormal_adaptive_immunity1.73660954
37MP0000767_abnormal_smooth_muscle1.71981571
38MP0003866_abnormal_defecation1.69260954
39MP0000465_gastrointestinal_hemorrhage1.67296077
40MP0003566_abnormal_cell_adhesion1.66205729
41MP0004510_myositis1.66078639
42MP0001790_abnormal_immune_system1.62463017
43MP0005387_immune_system_phenotype1.62463017
44* MP0003075_altered_response_to1.58929955
45* MP0000249_abnormal_blood_vessel1.52064941
46MP0002405_respiratory_system_inflammati1.51201756
47MP0009333_abnormal_splenocyte_physiolog1.51130482
48MP0002998_abnormal_bone_remodeling1.46982303
49MP0001845_abnormal_inflammatory_respons1.46207215
50MP0005166_decreased_susceptibility_to1.45087498
51MP0003279_aneurysm1.44975247
52MP0000685_abnormal_immune_system1.44764548
53MP0004272_abnormal_basement_membrane1.44135839
54MP0008469_abnormal_protein_level1.42391761
55MP0005164_abnormal_response_to1.40224128
56MP0000703_abnormal_thymus_morphology1.39737966
57MP0004947_skin_inflammation1.39577695
58MP0009278_abnormal_bone_marrow1.39258217
59MP0003448_altered_tumor_morphology1.36229719
60MP0004381_abnormal_hair_follicle1.34298200
61MP0005645_abnormal_hypothalamus_physiol1.29683793
62MP0008438_abnormal_cutaneous_collagen1.29675516
63MP0005023_abnormal_wound_healing1.25077827
64MP0001853_heart_inflammation1.23484047
65MP0002254_reproductive_system_inflammat1.22816635
66MP0009840_abnormal_foam_cell1.22628817
67MP0005075_abnormal_melanosome_morpholog1.20067009
68MP0000716_abnormal_immune_system1.19632677
69MP0002166_altered_tumor_susceptibility1.18638145
70MP0001958_emphysema1.18204323
71MP0010155_abnormal_intestine_physiology1.14242202
72MP0004782_abnormal_surfactant_physiolog1.10788646
73MP0002277_abnormal_respiratory_mucosa1.08941047
74MP0000689_abnormal_spleen_morphology1.07684434
75MP0001915_intracranial_hemorrhage1.06675578
76MP0003453_abnormal_keratinocyte_physiol1.04275356
77MP0002396_abnormal_hematopoietic_system1.03878059
78MP0009764_decreased_sensitivity_to1.03303391
79* MP0002398_abnormal_bone_marrow1.01219833
80MP0005670_abnormal_white_adipose0.98572651
81MP0000858_altered_metastatic_potential0.98327520
82MP0003183_abnormal_peptide_metabolism0.96124343
83MP0005174_abnormal_tail_pigmentation0.95471202
84* MP0002429_abnormal_blood_cell0.95296589
85MP0000015_abnormal_ear_pigmentation0.94354134
86MP0005390_skeleton_phenotype0.93692139
87MP0002006_tumorigenesis0.93329590
88MP0003646_muscle_fatigue0.92055349
89MP0002722_abnormal_immune_system0.91860281
90* MP0003045_fibrosis0.91357956
91MP0002163_abnormal_gland_morphology0.90358482
92MP0002933_joint_inflammation0.90110766
93MP0002693_abnormal_pancreas_physiology0.87822840
94MP0001873_stomach_inflammation0.87753223
95MP0002295_abnormal_pulmonary_circulatio0.86938414
96MP0004084_abnormal_cardiac_muscle0.86647165
97MP0000372_irregular_coat_pigmentation0.86383544
98MP0005397_hematopoietic_system_phenotyp0.83386605
99MP0001545_abnormal_hematopoietic_system0.83386605
100MP0005423_abnormal_somatic_nervous0.83087071
101* MP0005165_increased_susceptibility_to0.80898864
102MP0000371_diluted_coat_color0.79160227
103MP0003091_abnormal_cell_migration0.78944415
104MP0009384_cardiac_valve_regurgitation0.77486308
105MP0005595_abnormal_vascular_smooth0.76637423
106MP0003195_calcinosis0.74756345
107MP0003795_abnormal_bone_structure0.74443189
108MP0000920_abnormal_myelination0.74405377
109MP0001663_abnormal_digestive_system0.74016171
110MP0005379_endocrine/exocrine_gland_phen0.73314079
111MP0002090_abnormal_vision0.71146697
112MP0002928_abnormal_bile_duct0.69892830
113MP0001614_abnormal_blood_vessel0.69216751
114MP0009763_increased_sensitivity_to0.68863276
115MP0000604_amyloidosis0.66849739
116MP0001542_abnormal_bone_strength0.66064066
117MP0008873_increased_physiological_sensi0.65513805
118MP0005310_abnormal_salivary_gland0.64789424
119MP0003638_abnormal_response/metabolism_0.64626947
120MP0003252_abnormal_bile_duct0.64193208
121MP0010307_abnormal_tumor_latency0.63502697
122MP0002019_abnormal_tumor_incidence0.63496392
123MP0001348_abnormal_lacrimal_gland0.62197180
124MP0002009_preneoplasia0.61806241
125MP0002136_abnormal_kidney_physiology0.61117574
126MP0009765_abnormal_xenobiotic_induced0.60762441
127MP0008872_abnormal_physiological_respon0.52525834
128MP0002095_abnormal_skin_pigmentation0.51374391
129MP0008057_abnormal_DNA_replication0.51073977
130MP0002876_abnormal_thyroid_physiology0.49957980
131MP0008874_decreased_physiological_sensi0.47360461
132MP0001501_abnormal_sleep_pattern0.45833514
133MP0008877_abnormal_DNA_methylation0.45727790

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.02846884
2Glomerulonephritis (HP:0000099)5.25627160
3Abnormal delayed hypersensitivity skin test (HP:0002963)5.19235748
4Recurrent abscess formation (HP:0002722)5.07358771
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.04410085
6Abnormality of glycolipid metabolism (HP:0010969)5.04410085
7Abnormality of liposaccharide metabolism (HP:0010968)5.04410085
8Eczematoid dermatitis (HP:0000976)4.77723149
9Agammaglobulinemia (HP:0004432)4.74554522
10Recurrent cutaneous fungal infections (HP:0011370)4.71961213
11Chronic mucocutaneous candidiasis (HP:0002728)4.71961213
12Meningitis (HP:0001287)4.68711838
13Dysostosis multiplex (HP:0000943)4.52836623
14Abnormality of T cell number (HP:0011839)4.46815547
15Recurrent bacterial skin infections (HP:0005406)4.45856022
16T lymphocytopenia (HP:0005403)4.32799120
17Vacuolated lymphocytes (HP:0001922)4.32730810
18Vasculitis (HP:0002633)4.30464186
19Recurrent bronchitis (HP:0002837)4.30003759
20Pulmonary artery stenosis (HP:0004415)4.13661858
21Gastrointestinal stroma tumor (HP:0100723)4.11244266
22Increased cerebral lipofuscin (HP:0011813)4.02689924
23Abnormality of T cells (HP:0002843)3.96104298
24IgG deficiency (HP:0004315)3.96103759
25Arterial tortuosity (HP:0005116)3.92614547
26Recurrent sinusitis (HP:0011108)3.90287597
27Recurrent viral infections (HP:0004429)3.89782423
28Complement deficiency (HP:0004431)3.87915271
29Panhypogammaglobulinemia (HP:0003139)3.85950656
30Adactyly (HP:0009776)3.80541609
31Hematochezia (HP:0002573)3.80517567
32IgA deficiency (HP:0002720)3.80351346
33Duplicated collecting system (HP:0000081)3.75996146
34IgM deficiency (HP:0002850)3.71196100
35Vascular tortuosity (HP:0004948)3.69456103
36Pulmonary infiltrates (HP:0002113)3.67372456
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.62649978
38Encephalitis (HP:0002383)3.61097062
39Abnormality of T cell physiology (HP:0011840)3.57892820
40Stomatitis (HP:0010280)3.57418725
41Cerebral aneurysm (HP:0004944)3.56811441
42Lymphopenia (HP:0001888)3.55883867
43Abnormality of macrophages (HP:0004311)3.50155588
44Aortic aneurysm (HP:0004942)3.49234305
45Recurrent gram-negative bacterial infections (HP:0005420)3.48666284
46Abnormality of the prostate (HP:0008775)3.48342774
47Abnormality of cells of the lymphoid lineage (HP:0012140)3.45797566
48Long foot (HP:0001833)3.39585577
49Spontaneous hematomas (HP:0007420)3.33833085
50Hemoptysis (HP:0002105)3.27240679
51J-shaped sella turcica (HP:0002680)3.21813790
52Urinary glycosaminoglycan excretion (HP:0003541)3.16349227
53Mucopolysacchariduria (HP:0008155)3.16349227
54Abnormality of complement system (HP:0005339)3.15088773
55Gastrointestinal infarctions (HP:0005244)3.13751697
56Hepatosplenomegaly (HP:0001433)3.07668398
57Abnormality of the renal collecting system (HP:0004742)3.07158755
58Axonal loss (HP:0003447)3.06861898
59Myositis (HP:0100614)3.06375739
60Nephritis (HP:0000123)3.05570704
61Colitis (HP:0002583)3.01989717
62Autoimmune hemolytic anemia (HP:0001890)3.00863627
63Spondylolisthesis (HP:0003302)3.00788690
64Chest pain (HP:0100749)3.00069607
65Abnormality of polysaccharide metabolism (HP:0011012)2.92205288
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.92205288
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.92205288
68Thick nail (HP:0001805)2.91466908
69Interstitial pulmonary disease (HP:0006530)2.91215349
70Increased IgM level (HP:0003496)2.89706704
71Restrictive lung disease (HP:0002091)2.86697432
72Abnormality of the pleura (HP:0002103)2.84652420
73Orchitis (HP:0100796)2.74866758
74Urticaria (HP:0001025)2.74675143
75Disinhibition (HP:0000734)2.74236782
76Keratoconjunctivitis (HP:0001096)2.72586722
77Abnormality of B cell number (HP:0010975)2.69163391
78Large for gestational age (HP:0001520)2.67262941
79Aortic dissection (HP:0002647)2.66641953
80Recurrent skin infections (HP:0001581)2.66317616
81Mutism (HP:0002300)2.65932080
82Autoimmune thrombocytopenia (HP:0001973)2.63552188
83Abnormal platelet function (HP:0011869)2.55368089
84Impaired platelet aggregation (HP:0003540)2.55368089
85Elevated erythrocyte sedimentation rate (HP:0003565)2.54377556
86Chronic otitis media (HP:0000389)2.53006764
87Recurrent pneumonia (HP:0006532)2.51949905
88Abnormality of eosinophils (HP:0001879)2.50588647
89Cervical subluxation (HP:0003308)2.48614512
90Gangrene (HP:0100758)2.44576467
91Recurrent fungal infections (HP:0002841)2.42807806
92Retinal atrophy (HP:0001105)2.42207504
93Emphysema (HP:0002097)2.42004061
94Pulmonary embolism (HP:0002204)2.40833432
95Bronchitis (HP:0012387)2.40573200
96Thyroiditis (HP:0100646)2.39414644
97Lymphoma (HP:0002665)2.39147842
98Recurrent lower respiratory tract infections (HP:0002783)2.37858484
99Prostate neoplasm (HP:0100787)2.36635074
100Inflammation of the large intestine (HP:0002037)2.36471981
101Severe combined immunodeficiency (HP:0004430)2.35855989
102Obstructive lung disease (HP:0006536)2.35198100
103Chronic obstructive pulmonary disease (HP:0006510)2.35198100
104Retrobulbar optic neuritis (HP:0100654)2.34713886
105Optic neuritis (HP:0100653)2.34713886
106Broad face (HP:0000283)2.33770862
107Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.33618051
108Gingivitis (HP:0000230)2.31097748
109Hypoplastic nipples (HP:0002557)2.30985901
110Eosinophilia (HP:0001880)2.30860354
111Skin rash (HP:0000988)2.29601774
112Osteolytic defects of the phalanges of the hand (HP:0009771)2.29121262
113Osteolytic defects of the hand bones (HP:0009699)2.29121262
114Myocardial infarction (HP:0001658)2.29061529
115Mediastinal lymphadenopathy (HP:0100721)2.27145377
116Hemorrhage of the eye (HP:0011885)2.27096864
117Progressive neurologic deterioration (HP:0002344)2.24820068
118Premature loss of primary teeth (HP:0006323)2.24801546
119Increased IgE level (HP:0003212)2.23170040
120Ureteral obstruction (HP:0006000)2.22878394
121B lymphocytopenia (HP:0010976)2.22120928
122Acute lymphatic leukemia (HP:0006721)2.20092518
123Abnormality of the nasal mucosa (HP:0000433)2.18547636
124Striae distensae (HP:0001065)2.17940334
125Ureteral stenosis (HP:0000071)2.17938972
126Disproportionate tall stature (HP:0001519)2.15565169
127Abnormality of male internal genitalia (HP:0000022)2.15390081
128Viral hepatitis (HP:0006562)2.14633283
129Arthralgia (HP:0002829)2.11979607
130Amaurosis fugax (HP:0100576)2.11792450
131Deformed sella turcica (HP:0002681)2.11512148
132Leukocytosis (HP:0001974)2.11397621
133Joint stiffness (HP:0001387)2.10865229
134Papilloma (HP:0012740)2.10848708
135Verrucae (HP:0200043)2.10848708
136Cellulitis (HP:0100658)2.09515519
137Gastrointestinal inflammation (HP:0004386)2.08875571
138Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08711843
139Joint swelling (HP:0001386)2.07081273
140Agnosia (HP:0010524)2.07017541
141Stomach cancer (HP:0012126)2.07010850
142Joint hemorrhage (HP:0005261)2.06977428
143Facial diplegia (HP:0001349)2.05942486
144Hypochromic anemia (HP:0001931)2.05726703
145Pathologic fracture (HP:0002756)2.05588744
146Hemiplegia (HP:0002301)2.03755726
147Pulmonary fibrosis (HP:0002206)2.03506633
148Arterial thrombosis (HP:0004420)2.02059098
149Epistaxis (HP:0000421)2.01569853
150Chronic diarrhea (HP:0002028)1.99640360
151Sepsis (HP:0100806)1.98860474
152Palmoplantar hyperkeratosis (HP:0000972)1.98510196
153Purpura (HP:0000979)1.97736727
154Thoracic kyphosis (HP:0002942)1.94899381
155Chronic sinusitis (HP:0011109)1.93283711
156Conjunctival telangiectasia (HP:0000524)1.93120603
157Pustule (HP:0200039)1.93022211
158Granulocytopenia (HP:0001913)1.93012726
159Thickened calvaria (HP:0002684)1.92836295
160Hypergammaglobulinemia (HP:0010702)1.92635264
161Polyneuropathy (HP:0001271)1.91621214
162Keratoconjunctivitis sicca (HP:0001097)1.91253108
163Leukopenia (HP:0001882)1.90871336
164Esophageal varix (HP:0002040)1.90745671
165Combined immunodeficiency (HP:0005387)1.90102078
166Palmar hyperkeratosis (HP:0010765)1.88948184
167Osteomyelitis (HP:0002754)1.88419095
168Anorexia (HP:0002039)1.87854055
169Hypoplasia of the thymus (HP:0000778)1.85317314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR27.88676430
2GRK73.48074284
3TIE13.16499258
4MAPK153.00432944
5STK102.57311359
6TYK22.50111088
7CSF1R2.44748543
8KDR2.37426125
9IRAK42.37097016
10FRK2.32197788
11IRAK32.12625575
12TBK12.00659095
13MAP3K141.99813506
14RIPK41.97610995
15KIT1.89587992
16PAK41.87324132
17BLK1.85016770
18PDK21.77859878
19ERN11.75646458
20MAP3K131.72507514
21CLK11.67971218
22MAP4K11.64598660
23CSK1.62273046
24EPHB11.60444750
25MOS1.58237586
26FES1.55691364
27PRKCQ1.53013180
28JAK11.52915848
29ZAP701.40238399
30TXK1.28220576
31RIPK11.26312411
32HCK1.25748739
33IKBKB1.22798927
34CAMK1D1.21221843
35NUAK11.19837085
36GRK61.18043749
37GRK51.16196543
38TLK11.14712684
39EIF2AK31.11923305
40SIK21.10919291
41MAP2K31.09708552
42IKBKE1.09334800
43TNK21.06876872
44CDC42BPA1.05628998
45MAPK121.03426263
46IRAK11.01936088
47TEC0.99941114
48JAK30.99652267
49PTK60.99584481
50ACVR1B0.99338768
51PIK3CG0.99228756
52JAK20.96053649
53MAPK70.94040439
54MATK0.92645318
55LYN0.90741189
56STK240.89702922
57LCK0.88235926
58ITK0.87777510
59DAPK20.87398694
60CAMK1G0.87276598
61PIM20.87038502
62PTK2B0.85187434
63FGR0.79199905
64MYLK0.78101475
65CDK190.77474091
66NEK90.75836361
67MAP3K60.74807825
68DMPK0.72164903
69EIF2AK20.72151834
70PIM10.69412911
71TGFBR10.69075013
72FGFR30.69014667
73OXSR10.68050429
74FGFR40.67585327
75IGF1R0.66193913
76PDK10.65955297
77BTK0.65755000
78MST40.64734452
79SMG10.64077629
80BMPR1B0.63958262
81SYK0.61707158
82PAK20.60376172
83PKN20.59557628
84MAPK130.58952727
85PRPF4B0.58680392
86MAP3K30.58041950
87MARK30.57655789
88LRRK20.57300189
89TAOK30.56538214
90MAPKAPK20.55526616
91ARAF0.55450227
92VRK10.55290326
93EGFR0.54847604
94PRKCD0.54090347
95TTN0.54049592
96PRKCH0.52629571
97ZAK0.52181555
98MAPK110.51957502
99EPHA30.50870587
100TRPM70.50256569
101GSK3A0.50073203
102PDPK10.49344631
103CCNB10.48127192
104FYN0.47513572
105CHUK0.46800077
106TAF10.46328410
107TSSK60.46303150
108ABL10.45930296
109MELK0.45663312
110MAP3K70.45100744
111MAPKAPK50.44421898
112SGK20.44121156
113PRKD10.43516461
114SIK30.42688113
115GRK10.41794463
116PDGFRB0.41460483
117MAPKAPK30.40649094
118TRIB30.40325783
119RPS6KA40.39210352
120MAP2K20.38951162
121CAMKK20.38933523
122ADRBK20.38412893
123NEK60.36986153
124MAP2K60.35897121
125INSR0.35569805
126STK110.34925902
127HIPK20.34736750
128CDK30.32351850
129STK38L0.32101762
130CDK80.32046104
131MAP3K50.31851674
132PRKG20.30552274
133TNIK0.29490118
134BMPR20.29445948
135NLK0.28799183
136YES10.28436228
137PASK0.28431691
138MAPK40.27770757
139ROCK20.27431032
140CDK60.26009464
141RPS6KA60.25965008

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.27297548
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.85603509
3Other glycan degradation_Homo sapiens_hsa005113.79759821
4Type I diabetes mellitus_Homo sapiens_hsa049403.53752046
5Leishmaniasis_Homo sapiens_hsa051402.75585193
6Lysosome_Homo sapiens_hsa041422.71194743
7Osteoclast differentiation_Homo sapiens_hsa043802.60305229
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.51898046
9Pertussis_Homo sapiens_hsa051332.32089596
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.11016953
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93425998
12Malaria_Homo sapiens_hsa051441.90721421
13B cell receptor signaling pathway_Homo sapiens_hsa046621.87017275
14Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.78517907
15Antigen processing and presentation_Homo sapiens_hsa046121.73427689
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72719485
17Tuberculosis_Homo sapiens_hsa051521.69333947
18Toxoplasmosis_Homo sapiens_hsa051451.67475474
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.66508502
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62008192
21Legionellosis_Homo sapiens_hsa051341.58126838
22Hematopoietic cell lineage_Homo sapiens_hsa046401.57734533
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.54161928
24Rheumatoid arthritis_Homo sapiens_hsa053231.53710733
25Prion diseases_Homo sapiens_hsa050201.43498464
26Complement and coagulation cascades_Homo sapiens_hsa046101.43465628
27Phagosome_Homo sapiens_hsa041451.41293202
28Salmonella infection_Homo sapiens_hsa051321.40514617
29Graft-versus-host disease_Homo sapiens_hsa053321.39349215
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32445685
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31116516
32Measles_Homo sapiens_hsa051621.29632057
33Platelet activation_Homo sapiens_hsa046111.29406120
34TNF signaling pathway_Homo sapiens_hsa046681.28656739
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28445946
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20385797
37Influenza A_Homo sapiens_hsa051641.17690386
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17089732
39Chemokine signaling pathway_Homo sapiens_hsa040621.15895791
40African trypanosomiasis_Homo sapiens_hsa051431.15674187
41Apoptosis_Homo sapiens_hsa042101.07136860
42Systemic lupus erythematosus_Homo sapiens_hsa053221.05249035
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01439711
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.01091453
45Shigellosis_Homo sapiens_hsa051310.98128132
46Allograft rejection_Homo sapiens_hsa053300.95968085
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.95352949
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90844339
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89116627
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88032879
51Pancreatic cancer_Homo sapiens_hsa052120.88026351
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86322458
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86244276
54Ether lipid metabolism_Homo sapiens_hsa005650.83598784
55Hepatitis B_Homo sapiens_hsa051610.83298656
56Adherens junction_Homo sapiens_hsa045200.82943622
57Amoebiasis_Homo sapiens_hsa051460.82850125
58Notch signaling pathway_Homo sapiens_hsa043300.82338536
59Viral myocarditis_Homo sapiens_hsa054160.81660903
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81506081
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81203767
62Focal adhesion_Homo sapiens_hsa045100.77820766
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74452372
64Chronic myeloid leukemia_Homo sapiens_hsa052200.74166460
65Endocytosis_Homo sapiens_hsa041440.70565440
66Primary immunodeficiency_Homo sapiens_hsa053400.69013467
67Asthma_Homo sapiens_hsa053100.67283110
68Hepatitis C_Homo sapiens_hsa051600.66930248
69Sphingolipid metabolism_Homo sapiens_hsa006000.64832984
70T cell receptor signaling pathway_Homo sapiens_hsa046600.64395046
71Herpes simplex infection_Homo sapiens_hsa051680.64288022
72ECM-receptor interaction_Homo sapiens_hsa045120.61707873
73Small cell lung cancer_Homo sapiens_hsa052220.59373283
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57525783
75Dorso-ventral axis formation_Homo sapiens_hsa043200.57089373
76Rap1 signaling pathway_Homo sapiens_hsa040150.56018482
77Acute myeloid leukemia_Homo sapiens_hsa052210.50565885
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.49960596
79Renal cell carcinoma_Homo sapiens_hsa052110.49066860
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47303903
81Pancreatic secretion_Homo sapiens_hsa049720.46868843
82Colorectal cancer_Homo sapiens_hsa052100.46783369
83Renin-angiotensin system_Homo sapiens_hsa046140.46666662
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.46144769
85Arachidonic acid metabolism_Homo sapiens_hsa005900.44551488
86VEGF signaling pathway_Homo sapiens_hsa043700.42857534
87Autoimmune thyroid disease_Homo sapiens_hsa053200.40865710
88Mineral absorption_Homo sapiens_hsa049780.40265755
89Caffeine metabolism_Homo sapiens_hsa002320.39739858
90Proteoglycans in cancer_Homo sapiens_hsa052050.38794258
91HIF-1 signaling pathway_Homo sapiens_hsa040660.38099224
92Viral carcinogenesis_Homo sapiens_hsa052030.38060793
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37421354
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36791142
95Protein digestion and absorption_Homo sapiens_hsa049740.35210825
96Prolactin signaling pathway_Homo sapiens_hsa049170.35209024
97Renin secretion_Homo sapiens_hsa049240.34298917
98Ras signaling pathway_Homo sapiens_hsa040140.31418228
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.30954861
100* Epstein-Barr virus infection_Homo sapiens_hsa051690.30265986
101MAPK signaling pathway_Homo sapiens_hsa040100.30160852
102Linoleic acid metabolism_Homo sapiens_hsa005910.29519514
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29296122
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28643659
105Pathways in cancer_Homo sapiens_hsa052000.27785462
106HTLV-I infection_Homo sapiens_hsa051660.26879523
107Type II diabetes mellitus_Homo sapiens_hsa049300.26836970
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26383810
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26203084
110Estrogen signaling pathway_Homo sapiens_hsa049150.25874164
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25767601
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21080300
113Non-small cell lung cancer_Homo sapiens_hsa052230.20574970
114Homologous recombination_Homo sapiens_hsa034400.20490542
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19291168
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.19245568
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18774395
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16631461
119p53 signaling pathway_Homo sapiens_hsa041150.16285313
120Phototransduction_Homo sapiens_hsa047440.14369803
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.08778056
122Cholinergic synapse_Homo sapiens_hsa047250.07898988
123Glycerolipid metabolism_Homo sapiens_hsa005610.07351954
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07280840
125GnRH signaling pathway_Homo sapiens_hsa049120.06224535
126Insulin resistance_Homo sapiens_hsa049310.04217705
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.03863174
128Morphine addiction_Homo sapiens_hsa050320.02007721
129Inositol phosphate metabolism_Homo sapiens_hsa005620.01779001
130Collecting duct acid secretion_Homo sapiens_hsa049660.01218440
131Olfactory transduction_Homo sapiens_hsa047400.01112759

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