ENTPD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)7.08238349
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.88597987
3endocrine pancreas development (GO:0031018)6.59717360
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.19025933
5COPII vesicle coating (GO:0048208)5.95489206
6protein retention in ER lumen (GO:0006621)5.95147666
7peptide hormone processing (GO:0016486)5.88352954
8regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.77735394
9glandular epithelial cell differentiation (GO:0002067)5.73277945
10regulation of type B pancreatic cell apoptotic process (GO:2000674)5.47545634
11activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.12334812
12negative regulation of acute inflammatory response (GO:0002674)5.11805124
13negative regulation of hormone biosynthetic process (GO:0032353)5.11652743
14insulin secretion (GO:0030073)5.09306657
15ER overload response (GO:0006983)5.01340209
16signal peptide processing (GO:0006465)4.92360684
17positive regulation of nuclease activity (GO:0032075)4.85260979
18type B pancreatic cell development (GO:0003323)4.80297753
19vesicle coating (GO:0006901)4.71373471
20exocrine pancreas development (GO:0031017)4.63083582
21positive regulation of insulin secretion (GO:0032024)4.59782603
22glandular epithelial cell development (GO:0002068)4.56140795
23negative regulation of hormone metabolic process (GO:0032351)4.50893049
24regulation of nuclease activity (GO:0032069)4.40073084
25positive regulation of glycolytic process (GO:0045821)4.40072185
26regulation of insulin secretion (GO:0050796)4.34829778
27ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.34056057
28sequestering of metal ion (GO:0051238)4.32898375
29endoplasmic reticulum unfolded protein response (GO:0030968)4.27820956
30cellular response to unfolded protein (GO:0034620)4.24259827
31cellular response to topologically incorrect protein (GO:0035967)4.18250953
32ER-nucleus signaling pathway (GO:0006984)4.06812274
33intra-Golgi vesicle-mediated transport (GO:0006891)4.00315750
34regulation of peptide hormone secretion (GO:0090276)3.96539871
35negative regulation of norepinephrine secretion (GO:0010700)3.95897060
36detection of calcium ion (GO:0005513)3.95009004
37regulation of peptide secretion (GO:0002791)3.89548261
38positive regulation of respiratory burst (GO:0060267)3.78684225
39positive regulation of peptide hormone secretion (GO:0090277)3.77094851
40columnar/cuboidal epithelial cell development (GO:0002066)3.76518482
41peptide hormone secretion (GO:0030072)3.73859083
42peptide secretion (GO:0002790)3.71217932
43negative regulation of catecholamine secretion (GO:0033604)3.68463756
44macroautophagy (GO:0016236)3.65992679
45positive regulation of peptide secretion (GO:0002793)3.65593937
46nitric oxide mediated signal transduction (GO:0007263)3.62674285
47regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.58627665
48regulation of glucocorticoid secretion (GO:2000849)3.58390092
49protein N-linked glycosylation via asparagine (GO:0018279)3.58248725
50ER to Golgi vesicle-mediated transport (GO:0006888)3.57329205
51peptidyl-asparagine modification (GO:0018196)3.56428715
52negative regulation of protein oligomerization (GO:0032460)3.51319642
53response to endoplasmic reticulum stress (GO:0034976)3.50331702
54regulation of hormone secretion (GO:0046883)3.50186653
55negative regulation of glycoprotein biosynthetic process (GO:0010561)3.49105052
56positive regulation of growth hormone secretion (GO:0060124)3.48786343
57negative regulation of glycogen metabolic process (GO:0070874)3.48536360
58negative regulation of gluconeogenesis (GO:0045721)3.46447464
59desmosome organization (GO:0002934)3.44587406
60negative regulation of insulin secretion (GO:0046676)3.44418937
61zinc ion homeostasis (GO:0055069)3.36967202
62positive regulation of protein autophosphorylation (GO:0031954)3.34278231
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.32035035
64astrocyte differentiation (GO:0048708)3.31330025
65cellular ketone body metabolic process (GO:0046950)3.30610021
66response to unfolded protein (GO:0006986)3.30166235
67protein N-linked glycosylation (GO:0006487)3.28055727
68response to topologically incorrect protein (GO:0035966)3.24758535
69cellular response to vitamin D (GO:0071305)3.22538204
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.20028641
71synaptic vesicle maturation (GO:0016188)3.19856297
72protein localization to Golgi apparatus (GO:0034067)3.19416280
73toxin metabolic process (GO:0009404)3.19261267
74regulation of peptide transport (GO:0090087)3.17469947
75negative regulation of bone resorption (GO:0045779)3.12178839
76lactate metabolic process (GO:0006089)3.11610500
77positive regulation of hormone secretion (GO:0046887)3.11017904
78hemidesmosome assembly (GO:0031581)3.10413894
79positive regulation of vasodilation (GO:0045909)3.10087544
80cellular response to glucagon stimulus (GO:0071377)3.09315373
81regulation of glucocorticoid metabolic process (GO:0031943)3.08482061
82cerebellar Purkinje cell layer development (GO:0021680)3.03911971
83negative regulation of peptide hormone secretion (GO:0090278)3.03166438
84epithelial cell fate commitment (GO:0072148)3.00560423
85zinc ion transmembrane transport (GO:0071577)3.00005618
86regulation of steroid hormone biosynthetic process (GO:0090030)2.98496576
87Golgi organization (GO:0007030)2.96479152
88cAMP-mediated signaling (GO:0019933)2.95339245
89hormone secretion (GO:0046879)2.94593549
90dendritic spine morphogenesis (GO:0060997)2.93701610
91intestinal epithelial cell development (GO:0060576)2.93663521
92Golgi vesicle transport (GO:0048193)2.93166169
93response to hexose (GO:0009746)2.92994147
94peptide transport (GO:0015833)2.92842033
95GDP-mannose metabolic process (GO:0019673)2.91994197
96protein targeting to Golgi (GO:0000042)2.91505854
97negative regulation of peptide secretion (GO:0002792)2.91148819
98positive regulation of glycogen biosynthetic process (GO:0045725)2.90478106
99regulation of calcium ion-dependent exocytosis (GO:0017158)2.89403355
100ketone body metabolic process (GO:1902224)2.88489613
101fatty acid homeostasis (GO:0055089)2.87666098
102negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.87642621
103response to glucose (GO:0009749)2.87273981
104L-alpha-amino acid transmembrane transport (GO:1902475)2.87162870
105regulation of corticosteroid hormone secretion (GO:2000846)2.84895604
106positive regulation of insulin receptor signaling pathway (GO:0046628)2.84271730
107histone H4-K12 acetylation (GO:0043983)2.81504575
108establishment of nucleus localization (GO:0040023)2.79970455
109glutamate secretion (GO:0014047)2.78499223
110response to monosaccharide (GO:0034284)2.78398811
111inositol phosphate catabolic process (GO:0071545)2.77959064
112regulation of oxidative phosphorylation (GO:0002082)2.77625720
113hormone transport (GO:0009914)2.77390949
114negative regulation of Ras GTPase activity (GO:0034261)2.76765877
115regulation of Golgi to plasma membrane protein transport (GO:0042996)2.76686972
116regulation of energy homeostasis (GO:2000505)2.76092532
117regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75424896
118membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.75142845
119positive regulation of exocytosis (GO:0045921)2.74791424
120protein localization to endosome (GO:0036010)2.73899943
121regulation of autophagic vacuole assembly (GO:2000785)2.73241307
122carbohydrate homeostasis (GO:0033500)2.73209670
123glucose homeostasis (GO:0042593)2.73209670
124positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.72945403
125regulation of hexokinase activity (GO:1903299)2.72586628
126regulation of glucokinase activity (GO:0033131)2.72586628
127regulation of synaptic vesicle exocytosis (GO:2000300)2.72467172
128negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71621028
129regulation of protein glycosylation (GO:0060049)2.71203541
130chemosensory behavior (GO:0007635)2.70894658
131magnesium ion transport (GO:0015693)2.68283685
132glycerophospholipid catabolic process (GO:0046475)2.67970912
133membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67912193
134negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.67426215
135artery smooth muscle contraction (GO:0014824)2.65797893
136zinc ion transport (GO:0006829)2.65725459
137cellular zinc ion homeostasis (GO:0006882)2.65627265
138regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.65384202
139positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.65366392
140regulation of norepinephrine secretion (GO:0014061)2.64444590
141negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.64168687
142neurotransmitter secretion (GO:0007269)2.63347501
143negative regulation of glycogen biosynthetic process (GO:0045719)2.62665404
144regulation of heart rate by cardiac conduction (GO:0086091)2.62590397
145protein autoprocessing (GO:0016540)2.61646431
146calcium ion import (GO:0070509)2.60160443
147keratinocyte development (GO:0003334)2.58521594
148water-soluble vitamin biosynthetic process (GO:0042364)2.58382483
149diol metabolic process (GO:0034311)2.57397434
150long term synaptic depression (GO:0060292)2.53416888
151response to lipoprotein particle (GO:0055094)2.53064482
152positive regulation of nitric-oxide synthase activity (GO:0051000)2.53000540
153sphingoid metabolic process (GO:0046519)2.48856466
154positive regulation of neurotransmitter transport (GO:0051590)2.48273334
155establishment of protein localization to Golgi (GO:0072600)2.47312819
156adaptation of signaling pathway (GO:0023058)2.44823398
157regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.44705597
158positive regulation of glycogen metabolic process (GO:0070875)2.44657110
159negative regulation of dendrite morphogenesis (GO:0050774)2.42609784
160signal release (GO:0023061)2.42238188
161negative regulation of neurological system process (GO:0031645)2.41621217
162cardiac conduction (GO:0061337)2.41085752
163regulation of feeding behavior (GO:0060259)2.40208681
164regulation of vesicle fusion (GO:0031338)2.39486140
165regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.38005456
166Golgi transport vesicle coating (GO:0048200)10.1301745
167COPI coating of Golgi vesicle (GO:0048205)10.1301745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.76782904
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.07816232
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.11873596
4GATA1_22025678_ChIP-Seq_K562_Human2.98897240
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59022667
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39525935
7REST_21632747_ChIP-Seq_MESCs_Mouse2.24072357
8NR3C1_23031785_ChIP-Seq_PC12_Mouse2.19347217
9EZH2_22144423_ChIP-Seq_EOC_Human1.98063309
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96083262
11REST_18959480_ChIP-ChIP_MESCs_Mouse1.92204194
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83315032
13TAF15_26573619_Chip-Seq_HEK293_Human1.80871941
14SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76267555
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74384522
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73961597
17ZNF274_21170338_ChIP-Seq_K562_Hela1.72553963
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72240901
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.70999878
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70718865
21OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.70378977
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70044268
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69226773
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68404928
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67936452
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67262163
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67246005
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.65594308
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64417891
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63744609
31FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.63362199
32P300_19829295_ChIP-Seq_ESCs_Human1.63288996
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.57589682
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.53920462
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.51845610
36AR_25329375_ChIP-Seq_VCAP_Human1.50257512
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50051777
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49171274
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47534197
40REST_19997604_ChIP-ChIP_NEURONS_Mouse1.46269778
41ER_23166858_ChIP-Seq_MCF-7_Human1.43059358
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42554207
43CBP_20019798_ChIP-Seq_JUKART_Human1.42554207
44FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.42218129
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41773369
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40002789
47TCF4_23295773_ChIP-Seq_U87_Human1.39649654
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39020157
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38731620
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.38016225
51VDR_22108803_ChIP-Seq_LS180_Human1.37314566
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35339205
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34069078
54SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33536073
55IGF1R_20145208_ChIP-Seq_DFB_Human1.32910048
56P53_22387025_ChIP-Seq_ESCs_Mouse1.32772752
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32715433
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.31484651
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.31138150
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29340616
61CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28139331
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26905625
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26622709
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26528414
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26392318
66TP53_18474530_ChIP-ChIP_U2OS_Human1.26065051
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24993454
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.23656648
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23261110
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.22942602
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22336974
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22051280
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21917627
74HTT_18923047_ChIP-ChIP_STHdh_Human1.21388509
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.21155169
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.20985380
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.20334105
78SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20187171
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19169598
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19004066
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16898447
82FUS_26573619_Chip-Seq_HEK293_Human1.16774690
83TCF4_22108803_ChIP-Seq_LS180_Human1.16636355
84FOXA1_25552417_ChIP-Seq_VCAP_Human1.15996239
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.15973101
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.14828099
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.14777203
88STAT3_23295773_ChIP-Seq_U87_Human1.13793160
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13102720
90CDX2_22108803_ChIP-Seq_LS180_Human1.12376023
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.12363430
92RUNX2_22187159_ChIP-Seq_PCA_Human1.10890899
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10443879
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10279456
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10226765
96AR_21572438_ChIP-Seq_LNCaP_Human1.10066514
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08928809
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07729176
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.07585338
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07550006
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.07356807
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07350568
103SOX2_19829295_ChIP-Seq_ESCs_Human1.07132231
104NANOG_19829295_ChIP-Seq_ESCs_Human1.07132231
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06871498
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06478564
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06044990
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05290655
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05180116
110BCAT_22108803_ChIP-Seq_LS180_Human1.05117086
111SMAD3_21741376_ChIP-Seq_HESCs_Human1.04917784
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04595769
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04410138
114CTCF_18555785_Chip-Seq_ESCs_Mouse1.04041516
115* AHR_22903824_ChIP-Seq_MCF-7_Human1.03940539
116SMAD4_21799915_ChIP-Seq_A2780_Human1.03935509
117GATA3_24758297_ChIP-Seq_MCF-7_Human1.02934724
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02898598
119* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02584749
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02428018
121BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01667300
122TET1_21490601_ChIP-Seq_MESCs_Mouse1.01227755
123P300_18555785_Chip-Seq_ESCs_Mouse1.00729524
124PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00212778
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.99704648
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99338317
127TP53_22573176_ChIP-Seq_HFKS_Human0.98591012
128SOX2_20726797_ChIP-Seq_SW620_Human0.98477773
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97613686
130DROSHA_22980978_ChIP-Seq_HELA_Human0.97325309
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93113913
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92496975
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.92307207
134* SOX2_21211035_ChIP-Seq_LN229_Gbm0.91967335
135TFEB_21752829_ChIP-Seq_HELA_Human0.91711370
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89558734
137FLI1_21867929_ChIP-Seq_TH2_Mouse0.89482551
138GBX2_23144817_ChIP-Seq_PC3_Human0.89245206
139GATA1_19941826_ChIP-Seq_K562_Human0.87594892
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87099684
141CLOCK_20551151_ChIP-Seq_293T_Human0.86573128
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85414299
143EZH2_27304074_Chip-Seq_ESCs_Mouse0.85151621
144WT1_19549856_ChIP-ChIP_CCG9911_Human0.84895675
145SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83839449
146CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81981256
147BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81179645
148* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79972267
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79256486
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.78374562
151AR_19668381_ChIP-Seq_PC3_Human0.77499073
152CTCF_27219007_Chip-Seq_Bcells_Human0.76993141
153FOXH1_21741376_ChIP-Seq_ESCs_Human0.76991563
154FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76009427
155ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.75901882
156SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75714748
157* ERG_20517297_ChIP-Seq_VCAP_Human0.75257248
158* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75026379
159FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.73213173
160KDM2B_26808549_Chip-Seq_K562_Human0.72070497
161ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72007978
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71418447
163RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71243656
164FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70979764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.01120537
2MP0003283_abnormal_digestive_organ4.69912058
3MP0004043_abnormal_pH_regulation4.50761569
4MP0002909_abnormal_adrenal_gland4.47464062
5MP0002693_abnormal_pancreas_physiology3.95837067
6MP0009780_abnormal_chondrocyte_physiolo3.95208316
7MP0000013_abnormal_adipose_tissue3.89173286
8MP0001944_abnormal_pancreas_morphology3.60736776
9MP0003195_calcinosis3.57619703
10MP0010386_abnormal_urinary_bladder3.57534212
11MP0000678_abnormal_parathyroid_gland3.14632854
12MP0005379_endocrine/exocrine_gland_phen3.12393780
13MP0003183_abnormal_peptide_metabolism3.01366955
14MP0001986_abnormal_taste_sensitivity3.01212938
15MP0010234_abnormal_vibrissa_follicle2.85532792
16MP0002837_dystrophic_cardiac_calcinosis2.61986884
17MP0005220_abnormal_exocrine_pancreas2.51558336
18MP0004859_abnormal_synaptic_plasticity2.34643412
19MP0009046_muscle_twitch2.31300661
20MP0004270_analgesia2.24460090
21MP0002078_abnormal_glucose_homeostasis2.11696505
22MP0002102_abnormal_ear_morphology2.10247899
23MP0004264_abnormal_extraembryonic_tissu2.01587873
24MP0006072_abnormal_retinal_apoptosis1.97335596
25MP0004885_abnormal_endolymph1.96333695
26MP0002638_abnormal_pupillary_reflex1.92295575
27MP0008877_abnormal_DNA_methylation1.91447696
28MP0003122_maternal_imprinting1.87693836
29MP0010678_abnormal_skin_adnexa1.87530102
30MP0000003_abnormal_adipose_tissue1.87261855
31MP0005646_abnormal_pituitary_gland1.86382941
32MP0009745_abnormal_behavioral_response1.85775071
33MP0002064_seizures1.78832769
34MP0003300_gastrointestinal_ulcer1.73652946
35MP0000569_abnormal_digit_pigmentation1.73242141
36MP0000427_abnormal_hair_cycle1.69957275
37MP0005645_abnormal_hypothalamus_physiol1.64931144
38MP0003880_abnormal_central_pattern1.64376545
39MP0003121_genomic_imprinting1.62528485
40MP0001984_abnormal_olfaction1.61180408
41MP0001765_abnormal_ion_homeostasis1.59242691
42MP0000383_abnormal_hair_follicle1.57826340
43MP0002896_abnormal_bone_mineralization1.56917084
44MP0000462_abnormal_digestive_system1.56663456
45MP0002733_abnormal_thermal_nociception1.56570855
46MP0002734_abnormal_mechanical_nocicepti1.53219927
47MP0008961_abnormal_basal_metabolism1.50899741
48MP0000613_abnormal_salivary_gland1.47789616
49MP0000579_abnormal_nail_morphology1.46238700
50MP0002063_abnormal_learning/memory/cond1.43453150
51MP0003172_abnormal_lysosome_physiology1.42240713
52MP0002928_abnormal_bile_duct1.39947623
53MP0001440_abnormal_grooming_behavior1.38585588
54MP0002876_abnormal_thyroid_physiology1.37122097
55MP0005257_abnormal_intraocular_pressure1.36468465
56MP0003953_abnormal_hormone_level1.33318854
57MP0002234_abnormal_pharynx_morphology1.32679468
58MP0001270_distended_abdomen1.29797905
59MP0001970_abnormal_pain_threshold1.29206067
60MP0002163_abnormal_gland_morphology1.23852437
61MP0005310_abnormal_salivary_gland1.22393233
62MP0001756_abnormal_urination1.20927658
63MP0002735_abnormal_chemical_nociception1.20864056
64MP0004924_abnormal_behavior1.13613314
65MP0005386_behavior/neurological_phenoty1.13613314
66MP0005058_abnormal_lysosome_morphology1.13277860
67MP0004858_abnormal_nervous_system1.12369924
68MP0009643_abnormal_urine_homeostasis1.12316124
69MP0004510_myositis1.12241798
70MP0005551_abnormal_eye_electrophysiolog1.11943884
71MP0002090_abnormal_vision1.09419903
72MP0005535_abnormal_body_temperature1.05527230
73MP0008260_abnormal_autophagy1.01980809
74MP0003633_abnormal_nervous_system1.01640473
75MP0000681_abnormal_thyroid_gland1.00905598
76MP0006276_abnormal_autonomic_nervous1.00312009
77MP0000538_abnormal_urinary_bladder0.99423868
78MP0001486_abnormal_startle_reflex0.98436687
79MP0003866_abnormal_defecation0.98161940
80MP0001905_abnormal_dopamine_level0.97224918
81MP0000631_abnormal_neuroendocrine_gland0.96432810
82MP0001299_abnormal_eye_distance/0.92331307
83MP0003959_abnormal_lean_body0.91738416
84MP0005636_abnormal_mineral_homeostasis0.89339270
85MP0010352_gastrointestinal_tract_polyps0.88603924
86MP0001727_abnormal_embryo_implantation0.87826709
87MP0001502_abnormal_circadian_rhythm0.87313975
88MP0005367_renal/urinary_system_phenotyp0.86895481
89MP0000516_abnormal_urinary_system0.86895481
90MP0003045_fibrosis0.86738418
91MP0000230_abnormal_systemic_arterial0.84499092
92MP0003787_abnormal_imprinting0.84352444
93MP0000955_abnormal_spinal_cord0.84060736
94MP0003868_abnormal_feces_composition0.83988411
95MP0004134_abnormal_chest_morphology0.82719484
96MP0001188_hyperpigmentation0.82389809
97MP0002751_abnormal_autonomic_nervous0.81741555
98MP0005448_abnormal_energy_balance0.80083510
99MP0004085_abnormal_heartbeat0.79728895
100MP0001968_abnormal_touch/_nociception0.79335596
101MP0003879_abnormal_hair_cell0.79305278
102MP0002067_abnormal_sensory_capabilities0.75918670
103MP0003329_amyloid_beta_deposits0.74912126
104MP0008875_abnormal_xenobiotic_pharmacok0.74540434
105MP0003890_abnormal_embryonic-extraembry0.74536598
106MP0000647_abnormal_sebaceous_gland0.73561695
107MP0002272_abnormal_nervous_system0.73540267
108MP0008872_abnormal_physiological_respon0.72666644
109MP0003690_abnormal_glial_cell0.72140955
110MP0002118_abnormal_lipid_homeostasis0.71379817
111MP0000639_abnormal_adrenal_gland0.71326750
112MP0009672_abnormal_birth_weight0.70923035
113MP0010329_abnormal_lipoprotein_level0.70551043
114MP0001348_abnormal_lacrimal_gland0.69038330
115MP0003635_abnormal_synaptic_transmissio0.68614537
116MP0002184_abnormal_innervation0.67325256
117MP0001664_abnormal_digestion0.66994953
118MP0005187_abnormal_penis_morphology0.66607007
119MP0005375_adipose_tissue_phenotype0.65272479
120MP0004145_abnormal_muscle_electrophysio0.64797527
121MP0003119_abnormal_digestive_system0.64539931
122MP0006054_spinal_hemorrhage0.64124554
123MP0005365_abnormal_bile_salt0.63167614
124MP0002069_abnormal_eating/drinking_beha0.60952835
125MP0003252_abnormal_bile_duct0.58929751
126MP0005408_hypopigmentation0.57746149
127MP0002168_other_aberrant_phenotype0.56693445
128MP0005253_abnormal_eye_physiology0.56689396
129MP0002177_abnormal_outer_ear0.56436054
130MP0005083_abnormal_biliary_tract0.55090251
131MP0002736_abnormal_nociception_after0.53604617
132MP0009703_decreased_birth_body0.52468613
133MP0004811_abnormal_neuron_physiology0.51751119
134MP0002557_abnormal_social/conspecific_i0.51140727
135MP0001501_abnormal_sleep_pattern0.50784306
136MP0002138_abnormal_hepatobiliary_system0.50236666
137MP0002572_abnormal_emotion/affect_behav0.50195324
138MP0003634_abnormal_glial_cell0.49943955
139MP0002229_neurodegeneration0.49235313
140MP0003123_paternal_imprinting0.48524078
141MP0005452_abnormal_adipose_tissue0.48357079

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.46665065
2Hypoglycemic seizures (HP:0002173)6.71184870
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.70517850
4Symptomatic seizures (HP:0011145)6.06075539
5Hypoglycemic coma (HP:0001325)5.73887064
6Hyperglycemia (HP:0003074)4.85498658
7Insulin-resistant diabetes mellitus (HP:0000831)4.78501967
8Abnormality of calcium-phosphate metabolism (HP:0100530)4.64372027
9Abnormality of the pancreatic islet cells (HP:0006476)4.19812798
10Abnormality of endocrine pancreas physiology (HP:0012093)4.19812798
11Ketoacidosis (HP:0001993)4.17225892
12Decreased circulating renin level (HP:0003351)3.93448739
13Pancreatic islet-cell hyperplasia (HP:0004510)3.93032708
14Abnormal pancreas size (HP:0012094)3.86717531
15Large for gestational age (HP:0001520)3.77478013
16Late onset (HP:0003584)3.67438969
17Mucopolysacchariduria (HP:0008155)3.60673029
18Urinary glycosaminoglycan excretion (HP:0003541)3.60673029
19Agitation (HP:0000713)3.58143532
20Pheochromocytoma (HP:0002666)3.43383231
21Dysostosis multiplex (HP:0000943)3.39087618
22Hyperparathyroidism (HP:0000843)3.31089202
23Abnormality of polysaccharide metabolism (HP:0011012)3.27177437
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.27177437
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.27177437
26Hypokalemia (HP:0002900)3.16259772
27Dysautonomia (HP:0002459)3.04694787
28Abnormality of the intrinsic pathway (HP:0010989)3.01626635
29Neuroendocrine neoplasm (HP:0100634)2.99670212
30Visual hallucinations (HP:0002367)2.98395226
31Thoracolumbar scoliosis (HP:0002944)2.91325033
32Generalized aminoaciduria (HP:0002909)2.90551535
33Muscular hypotonia of the trunk (HP:0008936)2.85396171
34Hypomagnesemia (HP:0002917)2.81731636
35Osteomalacia (HP:0002749)2.80086268
36Retinal atrophy (HP:0001105)2.80033076
37Unilateral renal agenesis (HP:0000122)2.73968298
38Hyperphosphatemia (HP:0002905)2.73558060
39Febrile seizures (HP:0002373)2.68020155
40Plantar hyperkeratosis (HP:0007556)2.67673241
41Hypothermia (HP:0002045)2.67001737
42Hyperactive renin-angiotensin system (HP:0000841)2.65552640
43Insulin resistance (HP:0000855)2.64861955
44EEG with generalized epileptiform discharges (HP:0011198)2.56864878
45Hypercortisolism (HP:0001578)2.56732747
46Epidermoid cyst (HP:0200040)2.56697875
47Hypsarrhythmia (HP:0002521)2.55785599
48Abnormality of renin-angiotensin system (HP:0000847)2.53548328
49Hyperventilation (HP:0002883)2.52397418
50Hyperthyroidism (HP:0000836)2.48835491
51Epileptiform EEG discharges (HP:0011182)2.45190909
52Abnormality of potassium homeostasis (HP:0011042)2.44198600
53Onycholysis (HP:0001806)2.43330870
54Type I diabetes mellitus (HP:0100651)2.40966379
55Epileptic encephalopathy (HP:0200134)2.40555048
56Broad-based gait (HP:0002136)2.40516720
57Hyperkalemia (HP:0002153)2.38602853
58Congenital glaucoma (HP:0001087)2.37732460
59Cortical visual impairment (HP:0100704)2.32463235
60Papilledema (HP:0001085)2.32218555
61Focal motor seizures (HP:0011153)2.30115093
62Chronic bronchitis (HP:0004469)2.28812019
63Prominent metopic ridge (HP:0005487)2.26406505
64Conjugated hyperbilirubinemia (HP:0002908)2.26347416
65Milia (HP:0001056)2.24992114
66Hypotension (HP:0002615)2.24248369
67Progressive neurologic deterioration (HP:0002344)2.23361423
68Palmoplantar hyperkeratosis (HP:0000972)2.22608801
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21820639
70Failure to thrive in infancy (HP:0001531)2.21425901
71Enlarged penis (HP:0000040)2.21045706
72Menstrual irregularities (HP:0000858)2.17336358
73Ketosis (HP:0001946)2.15781257
74Hypoplastic labia majora (HP:0000059)2.15407225
75Restlessness (HP:0000711)2.14084190
76Palmar hyperkeratosis (HP:0010765)2.06701930
77Exocrine pancreatic insufficiency (HP:0001738)2.03721991
78Intention tremor (HP:0002080)2.02368974
79Gaze-evoked nystagmus (HP:0000640)2.00711078
80Widely spaced teeth (HP:0000687)1.99526508
81Adrenal overactivity (HP:0002717)1.99081402
82Polydipsia (HP:0001959)1.98864999
83Abnormal drinking behavior (HP:0030082)1.98864999
84Methylmalonic acidemia (HP:0002912)1.97904894
85Hypoplasia of the fovea (HP:0007750)1.97647406
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.97647406
87Hemiparesis (HP:0001269)1.94665016
88Aplasia/hypoplasia of the uterus (HP:0008684)1.94347300
89Abnormality of the metopic suture (HP:0005556)1.92452059
90Abnormality of the labia majora (HP:0012881)1.91930816
91Disproportionate short-trunk short stature (HP:0003521)1.91227590
92Absent eyebrow (HP:0002223)1.90618742
93Abnormality of chloride homeostasis (HP:0011422)1.90520809
94Truncal ataxia (HP:0002078)1.90464654
95Growth hormone excess (HP:0000845)1.90062600
96Tongue fasciculations (HP:0001308)1.89721342
97Abnormal protein glycosylation (HP:0012346)1.89659672
98Abnormal glycosylation (HP:0012345)1.89659672
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89659672
100Abnormal protein N-linked glycosylation (HP:0012347)1.89659672
101Anxiety (HP:0000739)1.89334131
102Macroorchidism (HP:0000053)1.88381199
103Gout (HP:0001997)1.87950463
104Missing ribs (HP:0000921)1.87391466
105Abnormality of magnesium homeostasis (HP:0004921)1.87197942
106Popliteal pterygium (HP:0009756)1.86812226
107Focal seizures (HP:0007359)1.86450211
108Limb hypertonia (HP:0002509)1.85365109
109Hypokalemic alkalosis (HP:0001949)1.85248891
110Syncope (HP:0001279)1.85177069
111Labial hypoplasia (HP:0000066)1.85163885
112Abnormality of the fovea (HP:0000493)1.84237537
113Abnormal autonomic nervous system physiology (HP:0012332)1.83799032
114Generalized tonic-clonic seizures (HP:0002069)1.82526859
115Tachypnea (HP:0002789)1.81818069
116Abnormality of the renal cortex (HP:0011035)1.81403894
117Abnormality of the distal phalanges of the toes (HP:0010182)1.80426204
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79654813
119Postural tremor (HP:0002174)1.78984956
120Progressive inability to walk (HP:0002505)1.77332253
121Abdominal distention (HP:0003270)1.75975561
122Ventricular fibrillation (HP:0001663)1.75175029
123Villous atrophy (HP:0011473)1.74303914
124Abnormality of small intestinal villus morphology (HP:0011472)1.74303914
125Oligomenorrhea (HP:0000876)1.72336110
126Cystic liver disease (HP:0006706)1.71558811
127Hypophosphatemia (HP:0002148)1.70514581
128Progressive cerebellar ataxia (HP:0002073)1.70277331
129Calf muscle hypertrophy (HP:0008981)1.70228144
130Increased circulating renin level (HP:0000848)1.69847925
131Renal cortical cysts (HP:0000803)1.69177328
132Generalized hyperpigmentation (HP:0007440)1.69015435
133Metaphyseal dysplasia (HP:0100255)1.68204766
134Neoplasm of the adrenal cortex (HP:0100641)1.67367934
135Fragile nails (HP:0001808)1.66992696
136Irregular vertebral endplates (HP:0003301)1.66894941
137Dialeptic seizures (HP:0011146)1.65780710
138Medial flaring of the eyebrow (HP:0010747)1.62202801
139Atonic seizures (HP:0010819)1.61123677
140Downturned corners of mouth (HP:0002714)1.61012636
141Glucose intolerance (HP:0000833)1.60500856
142Molar tooth sign on MRI (HP:0002419)1.59644417
143Abnormality of midbrain morphology (HP:0002418)1.59644417
144Testicular neoplasm (HP:0010788)1.59361920
145Nephronophthisis (HP:0000090)1.59136257
146Furrowed tongue (HP:0000221)1.58643902
147Alopecia of scalp (HP:0002293)1.58478092
148Steatorrhea (HP:0002570)1.58060650
149Hypoplastic female external genitalia (HP:0012815)1.57660898
150Hepatic necrosis (HP:0002605)1.56959828
151Congenital stationary night blindness (HP:0007642)1.56312520
152Status epilepticus (HP:0002133)1.54785417
153Absent speech (HP:0001344)1.54691601
154Hamartoma of the eye (HP:0010568)1.52522641
155Tetany (HP:0001281)1.50799276
156Muscle fibrillation (HP:0010546)1.50065757
157Hypokinesia (HP:0002375)1.49576381
158Hepatoblastoma (HP:0002884)1.49559080
159Abnormality of the renal medulla (HP:0100957)1.48536597
160Abnormality of vitamin metabolism (HP:0100508)1.48067685
161Right ventricular cardiomyopathy (HP:0011663)1.47872458
162Muscle hypertrophy of the lower extremities (HP:0008968)1.47443621
163Polyphagia (HP:0002591)1.46918778
164Methylmalonic aciduria (HP:0012120)1.46472343
165Lower limb hyperreflexia (HP:0002395)1.46219548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.24294380
2PASK5.31752963
3MAP3K24.26102571
4MAPK154.08324975
5TAOK33.43082625
6HIPK23.16918904
7FRK2.78078643
8FGFR22.58020308
9NTRK12.52619916
10WNK42.49983753
11DAPK22.37104895
12ERN12.36922939
13NTRK32.35203860
14PRKD32.29312337
15CASK2.21926355
16EPHA32.16678108
17MAP3K11.89328132
18PHKG21.84489567
19PHKG11.84489567
20EPHA41.83474323
21SCYL21.74882224
22FLT31.74250303
23AKT31.65526499
24LATS11.58513481
25GRK11.47710722
26CDC42BPA1.44629680
27UHMK11.41942142
28CAMKK21.38897553
29MAP3K31.35703195
30WNK31.31117790
31PDGFRA1.30097806
32IRAK41.28532120
33MARK11.26036238
34TRIB31.24783363
35CSNK1G11.24686445
36PTK2B1.22092557
37PTK21.21680282
38ADRBK21.20680470
39PINK11.20017146
40STK381.18649007
41PAK31.17886721
42KSR21.15370913
43STK38L1.12439598
44IRAK11.11595957
45MST41.11141610
46MAP3K121.10898019
47FER1.10841563
48RET1.10597870
49PTK61.04922145
50MAP2K21.03114612
51MAP2K61.02135733
52CSNK1G31.02074603
53BCKDK1.01784149
54PRKCH0.99464410
55TNIK0.99405355
56OXSR10.98949319
57WNK10.98676252
58IRAK30.97900922
59ACVR1B0.96788475
60CAMK2A0.93125423
61DYRK1B0.90728287
62EPHA20.90024901
63NLK0.88199637
64MAP2K70.86688794
65PRKCE0.86572426
66PLK20.86318100
67MET0.83794224
68RPS6KA20.83452780
69STK390.78904499
70STK110.77261182
71TRPM70.77125699
72STK160.75175289
73BRAF0.75044673
74MAP3K90.72828303
75FGFR40.72824816
76CDK30.72222634
77BRSK20.71208401
78PAK60.70968874
79EIF2AK30.67588464
80MAP4K20.67362207
81CAMKK10.66628158
82ROCK10.66459127
83PNCK0.65419132
84DAPK10.65148125
85STK30.64101490
86TGFBR20.63576236
87BMPR1B0.63187168
88GRK50.62602816
89SIK10.62521235
90NUAK10.62199014
91PRKAA20.60755404
92ERBB30.59911569
93ARAF0.59662473
94CAMK2D0.58505840
95MAP2K10.58316100
96TESK10.58284419
97ILK0.57038265
98SGK4940.55873969
99SGK2230.55873969
100PRKCI0.53963045
101SGK20.53197349
102TRIM280.51845378
103CDK50.51633597
104MAPK130.51427665
105NTRK20.50807220
106SIK20.50267329
107PRKCZ0.50239609
108EPHB10.49964714
109PRKAA10.49292441
110CSNK1A10.47941219
111TAOK10.47688549
112MINK10.47577031
113FGFR30.46622394
114CAMK2G0.46356871
115JAK20.45909710
116SGK10.45891283
117PRKD20.45732678
118IRAK20.45729992
119BMPR20.43756035
120MST1R0.43528004
121CSNK1A1L0.43393455
122NEK60.43252631
123MAP2K40.42926312
124MAPKAPK30.39487731
125BRSK10.38250837
126ADRBK10.35347281
127MAP3K40.34712363
128CAMK2B0.34580204
129PRKACG0.34106601
130PRKCG0.32734544
131GSK3A0.31606974
132RPS6KB10.31372128
133SGK30.31189340
134PIK3CG0.29972695
135PRKACA0.29941245
136LMTK20.29306300
137MTOR0.29134887
138JAK10.28944297
139ALK0.28147454
140IGF1R0.26914497
141PDGFRB0.25526491
142ITK0.25079798
143TSSK60.24825589
144PRKD10.24290400
145NME10.22137597
146CSNK1G20.20582469
147LIMK10.20138429
148BCR0.20050769
149DYRK1A0.19704996
150PRKCA0.19491271

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.39067377
2Protein export_Homo sapiens_hsa030605.02506045
3Insulin secretion_Homo sapiens_hsa049113.27406927
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.16917391
5Sulfur metabolism_Homo sapiens_hsa009203.10190181
6Vibrio cholerae infection_Homo sapiens_hsa051102.43288125
7Type II diabetes mellitus_Homo sapiens_hsa049302.25546767
8Fatty acid elongation_Homo sapiens_hsa000622.17613399
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11615345
10Type I diabetes mellitus_Homo sapiens_hsa049402.02622432
11Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96316561
12Cocaine addiction_Homo sapiens_hsa050301.92705921
13Nicotine addiction_Homo sapiens_hsa050331.83488373
14N-Glycan biosynthesis_Homo sapiens_hsa005101.77320277
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74715499
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67948529
17Synaptic vesicle cycle_Homo sapiens_hsa047211.67394781
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61100426
19Amphetamine addiction_Homo sapiens_hsa050311.56288685
20Taste transduction_Homo sapiens_hsa047421.51425142
21Phototransduction_Homo sapiens_hsa047441.47699185
22Lysosome_Homo sapiens_hsa041421.44449934
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40824927
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36093246
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33339891
26Collecting duct acid secretion_Homo sapiens_hsa049661.28248469
27Dopaminergic synapse_Homo sapiens_hsa047281.25123962
28Vitamin B6 metabolism_Homo sapiens_hsa007501.21272746
29Pancreatic secretion_Homo sapiens_hsa049721.20806223
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.20035045
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16926517
32Caffeine metabolism_Homo sapiens_hsa002321.13333732
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12076294
34Regulation of autophagy_Homo sapiens_hsa041401.10231647
35Long-term potentiation_Homo sapiens_hsa047201.07973731
36Cholinergic synapse_Homo sapiens_hsa047251.06422983
37Thyroid hormone synthesis_Homo sapiens_hsa049181.05684846
38Ovarian steroidogenesis_Homo sapiens_hsa049131.04695776
39Glucagon signaling pathway_Homo sapiens_hsa049221.03951228
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03383958
41Circadian entrainment_Homo sapiens_hsa047131.03307811
42Selenocompound metabolism_Homo sapiens_hsa004501.02989802
43Folate biosynthesis_Homo sapiens_hsa007901.01459605
44Circadian rhythm_Homo sapiens_hsa047101.01435927
45Serotonergic synapse_Homo sapiens_hsa047261.00966536
46Insulin resistance_Homo sapiens_hsa049310.99417137
47Other glycan degradation_Homo sapiens_hsa005110.97860441
48beta-Alanine metabolism_Homo sapiens_hsa004100.94642519
49GABAergic synapse_Homo sapiens_hsa047270.94484769
50Prolactin signaling pathway_Homo sapiens_hsa049170.85170701
51Estrogen signaling pathway_Homo sapiens_hsa049150.85094625
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83545627
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83400525
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83222984
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81634983
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81116526
57Prion diseases_Homo sapiens_hsa050200.76926105
58Ether lipid metabolism_Homo sapiens_hsa005650.76645947
59ABC transporters_Homo sapiens_hsa020100.73259690
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71583658
61Fatty acid metabolism_Homo sapiens_hsa012120.69838660
62Morphine addiction_Homo sapiens_hsa050320.68049614
63Nitrogen metabolism_Homo sapiens_hsa009100.67923919
64Renin secretion_Homo sapiens_hsa049240.64730965
65Galactose metabolism_Homo sapiens_hsa000520.64232828
66Insulin signaling pathway_Homo sapiens_hsa049100.63467624
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62621012
68Mineral absorption_Homo sapiens_hsa049780.61333210
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59422295
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.57824847
71Propanoate metabolism_Homo sapiens_hsa006400.57340055
72Calcium signaling pathway_Homo sapiens_hsa040200.57116122
73Alcoholism_Homo sapiens_hsa050340.56915966
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56267203
75Long-term depression_Homo sapiens_hsa047300.55398696
76Steroid biosynthesis_Homo sapiens_hsa001000.55057702
77Sphingolipid metabolism_Homo sapiens_hsa006000.53976228
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53646508
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53481963
80Dorso-ventral axis formation_Homo sapiens_hsa043200.52642569
81Peroxisome_Homo sapiens_hsa041460.52567525
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50871568
83Cardiac muscle contraction_Homo sapiens_hsa042600.49370720
84Thyroid cancer_Homo sapiens_hsa052160.49041123
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48423582
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48363126
87Tryptophan metabolism_Homo sapiens_hsa003800.48180844
88mTOR signaling pathway_Homo sapiens_hsa041500.47405552
89Butanoate metabolism_Homo sapiens_hsa006500.46616645
90Glutamatergic synapse_Homo sapiens_hsa047240.45948859
91Oxidative phosphorylation_Homo sapiens_hsa001900.45403477
92Gap junction_Homo sapiens_hsa045400.44728259
93Gastric acid secretion_Homo sapiens_hsa049710.43508835
94Fatty acid degradation_Homo sapiens_hsa000710.41639424
95Oxytocin signaling pathway_Homo sapiens_hsa049210.41424986
96GnRH signaling pathway_Homo sapiens_hsa049120.41355080
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41262618
98Tight junction_Homo sapiens_hsa045300.39229095
99Melanogenesis_Homo sapiens_hsa049160.39031083
100cAMP signaling pathway_Homo sapiens_hsa040240.38201019
101Fat digestion and absorption_Homo sapiens_hsa049750.38196993
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37460209
103Axon guidance_Homo sapiens_hsa043600.36522416
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36041730
105Starch and sucrose metabolism_Homo sapiens_hsa005000.34894493
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34363174
107AMPK signaling pathway_Homo sapiens_hsa041520.33949223
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.33448382
109Bile secretion_Homo sapiens_hsa049760.33067451
110Inositol phosphate metabolism_Homo sapiens_hsa005620.32667069
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.32484801
112Salivary secretion_Homo sapiens_hsa049700.32188183
113Olfactory transduction_Homo sapiens_hsa047400.31912576
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.31510138
115Glycerolipid metabolism_Homo sapiens_hsa005610.30982706
116Ras signaling pathway_Homo sapiens_hsa040140.30388217
117Chemical carcinogenesis_Homo sapiens_hsa052040.30224037
118Phagosome_Homo sapiens_hsa041450.29292913
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28602858
120Prostate cancer_Homo sapiens_hsa052150.28573993
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28031250
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27684185
123Bladder cancer_Homo sapiens_hsa052190.27012540
124Endocytosis_Homo sapiens_hsa041440.26698370
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25873573
126Endometrial cancer_Homo sapiens_hsa052130.25389239
127Protein digestion and absorption_Homo sapiens_hsa049740.25291860
128Glioma_Homo sapiens_hsa052140.24600470
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24176044
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24138415
131Alzheimers disease_Homo sapiens_hsa050100.24081050
132Histidine metabolism_Homo sapiens_hsa003400.22370631
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22336877
134Fructose and mannose metabolism_Homo sapiens_hsa000510.21150957
135FoxO signaling pathway_Homo sapiens_hsa040680.20127757
136Rheumatoid arthritis_Homo sapiens_hsa053230.18064480
137Linoleic acid metabolism_Homo sapiens_hsa005910.17653817
138Phenylalanine metabolism_Homo sapiens_hsa003600.17052984

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