ENTPD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1carnitine shuttle (GO:0006853)4.30303175
2valine metabolic process (GO:0006573)4.26582901
3lysine catabolic process (GO:0006554)4.22091807
4lysine metabolic process (GO:0006553)4.22091807
5positive regulation of gamma-delta T cell activation (GO:0046645)4.06412209
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.03951764
7negative regulation of cell killing (GO:0031342)4.03951764
8amino-acid betaine transport (GO:0015838)3.96958040
9carnitine transport (GO:0015879)3.96958040
10fatty acid transmembrane transport (GO:1902001)3.92914812
11carnitine transmembrane transport (GO:1902603)3.82007162
122-oxoglutarate metabolic process (GO:0006103)3.80016469
13tricarboxylic acid cycle (GO:0006099)3.78598095
14phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.77098488
15tricarboxylic acid metabolic process (GO:0072350)3.73217653
16succinate metabolic process (GO:0006105)3.65141600
17quaternary ammonium group transport (GO:0015697)3.61617008
18negative thymic T cell selection (GO:0045060)3.55931797
19negative T cell selection (GO:0043383)3.54997333
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50419824
21aspartate family amino acid catabolic process (GO:0009068)3.46029336
22branched-chain amino acid metabolic process (GO:0009081)3.45289396
23fatty acid beta-oxidation (GO:0006635)3.43294960
24activated T cell proliferation (GO:0050798)3.40927234
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.37499103
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35330151
27histone H3-K36 demethylation (GO:0070544)3.32582499
28branched-chain amino acid catabolic process (GO:0009083)3.28755235
29positive T cell selection (GO:0043368)3.27552256
30regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.20980258
31short-chain fatty acid metabolic process (GO:0046459)3.20068864
32oxaloacetate metabolic process (GO:0006107)3.17642673
33positive thymic T cell selection (GO:0045059)3.16200872
34regulation of B cell receptor signaling pathway (GO:0050855)3.15920861
35NADH metabolic process (GO:0006734)3.15851810
36cell communication by electrical coupling (GO:0010644)3.10031317
37regulation of fatty acid oxidation (GO:0046320)3.07355111
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07050962
39regulation of sequestering of triglyceride (GO:0010889)3.05845060
40fatty acid oxidation (GO:0019395)3.05831999
41drug transmembrane transport (GO:0006855)3.05614709
42regulation of skeletal muscle contraction (GO:0014819)3.04255775
43B cell receptor signaling pathway (GO:0050853)3.02773521
44lipid oxidation (GO:0034440)3.01594133
45fatty acid catabolic process (GO:0009062)3.01362442
46biotin metabolic process (GO:0006768)3.01312268
47regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.98346331
48negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97572415
49sodium ion export (GO:0071436)2.94728427
50regulation of ARF protein signal transduction (GO:0032012)2.93407794
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91406615
52T cell selection (GO:0045058)2.91236102
53response to interleukin-15 (GO:0070672)2.89370933
54thymic T cell selection (GO:0045061)2.87036134
55cellular potassium ion homeostasis (GO:0030007)2.84915229
56regulation of acyl-CoA biosynthetic process (GO:0050812)2.83321692
57carnitine metabolic process (GO:0009437)2.83242357
58amino-acid betaine metabolic process (GO:0006577)2.82883243
59regulation of gamma-delta T cell activation (GO:0046643)2.82678498
60regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.81897193
61embryonic process involved in female pregnancy (GO:0060136)2.81846273
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81588633
63regulation of Rap GTPase activity (GO:0032317)2.81564596
64germinal center formation (GO:0002467)2.77723547
65antigen processing and presentation of endogenous antigen (GO:0019883)2.76658204
66monocarboxylic acid catabolic process (GO:0072329)2.75839944
67regulation of gamma-delta T cell differentiation (GO:0045586)2.75558910
68dicarboxylic acid biosynthetic process (GO:0043650)2.73126731
69organic cation transport (GO:0015695)2.72473127
70regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.72208224
71intracellular lipid transport (GO:0032365)2.71075221
72glycine transport (GO:0015816)2.71021314
73cell communication involved in cardiac conduction (GO:0086065)2.70986707
74regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.70354171
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69059463
76cellular modified amino acid catabolic process (GO:0042219)2.68976348
77glycogen catabolic process (GO:0005980)2.68790638
78activation of protein kinase A activity (GO:0034199)2.68631058
79sarcoplasmic reticulum calcium ion transport (GO:0070296)2.68385807
80cellular extravasation (GO:0045123)2.68165750
81alpha-linolenic acid metabolic process (GO:0036109)2.67479912
82regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.66698436
83establishment of nucleus localization (GO:0040023)2.65318116
84alanine transport (GO:0032328)2.64728038
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64692860
86proline transport (GO:0015824)2.63275150
87positive regulation of granulocyte differentiation (GO:0030854)2.62824839
88positive regulation of Rap GTPase activity (GO:0032854)2.61731107
89positive regulation of fatty acid oxidation (GO:0046321)2.61482768
90relaxation of cardiac muscle (GO:0055119)2.60575133
91tolerance induction (GO:0002507)2.60361493
92plasma membrane repair (GO:0001778)2.59812652
93regulation of T cell tolerance induction (GO:0002664)2.58886290
94nerve growth factor signaling pathway (GO:0038180)2.58000044
95regulation of fatty acid beta-oxidation (GO:0031998)2.57430873
96potassium ion import (GO:0010107)2.57084232
97negative regulation of T cell mediated immunity (GO:0002710)2.56979518
98positive regulation of fatty acid beta-oxidation (GO:0032000)2.56842067
99synaptic vesicle maturation (GO:0016188)2.55798095
100leukocyte aggregation (GO:0070486)2.55131126
101response to laminar fluid shear stress (GO:0034616)2.54803526
102histone lysine demethylation (GO:0070076)2.54614612
103regulation of cofactor metabolic process (GO:0051193)2.53872006
104regulation of coenzyme metabolic process (GO:0051196)2.53872006
105acetyl-CoA metabolic process (GO:0006084)2.53626277
106locomotory exploration behavior (GO:0035641)2.51487579
107regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51306481
108glucan catabolic process (GO:0009251)2.49360613
109glyoxylate metabolic process (GO:0046487)2.49237909
110response to muramyl dipeptide (GO:0032495)2.49158368
111negative regulation of lymphocyte mediated immunity (GO:0002707)2.48248042
112histone H3-K4 trimethylation (GO:0080182)2.47459640
113regulation of NFAT protein import into nucleus (GO:0051532)2.46420515
114cardiac muscle contraction (GO:0060048)2.46263310
115positive regulation of glycolytic process (GO:0045821)2.46107599
116regulation of synapse structural plasticity (GO:0051823)2.44980975
117homocysteine metabolic process (GO:0050667)2.44434571
118cellular ketone body metabolic process (GO:0046950)2.43299911
119histone demethylation (GO:0016577)2.43042896
120potassium ion homeostasis (GO:0055075)2.42296720
121synaptic vesicle docking involved in exocytosis (GO:0016081)2.40592580
122cellular sodium ion homeostasis (GO:0006883)2.40383838
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.40016864
124actin-myosin filament sliding (GO:0033275)2.39603094
125muscle filament sliding (GO:0030049)2.39603094
126cysteine metabolic process (GO:0006534)2.38808183
127L-phenylalanine catabolic process (GO:0006559)2.38263743
128erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.38263743
129pathway-restricted SMAD protein phosphorylation (GO:0060389)2.36757490
130response to mercury ion (GO:0046689)2.35421705
131histone H3-K9 demethylation (GO:0033169)2.35196905
132regulation of tolerance induction (GO:0002643)2.35192577
133membrane depolarization during action potential (GO:0086010)2.34449331
134positive regulation of tolerance induction (GO:0002645)2.34241082
135phosphate ion transport (GO:0006817)2.34098351
136cellular polysaccharide catabolic process (GO:0044247)2.33927908
137regulation of membrane repolarization (GO:0060306)2.33502007
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.33198750
139L-phenylalanine metabolic process (GO:0006558)2.33198750
140positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.32884913
141mannose metabolic process (GO:0006013)2.31787058
142kynurenine metabolic process (GO:0070189)2.30823531
143drug transport (GO:0015893)2.30415296
144creatine metabolic process (GO:0006600)2.30172905
145signal complex assembly (GO:0007172)2.30051189
146negative regulation of potassium ion transmembrane transport (GO:1901380)2.29353074
147B cell homeostasis (GO:0001782)2.28831721
148cellular response to interleukin-15 (GO:0071350)2.28605807
149negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.28352909
150cellular response to nerve growth factor stimulus (GO:1990090)2.27863371
151response to nerve growth factor (GO:1990089)2.27863371
152striated muscle contraction (GO:0006941)2.27723928
153substrate-dependent cell migration (GO:0006929)2.25936887
154positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.25175711
155negative regulation of myotube differentiation (GO:0010832)2.24983384
156negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.24438789
157regulation of histone H3-K27 methylation (GO:0061085)2.23610553
158cellular response to catecholamine stimulus (GO:0071870)2.22612720
159cellular response to monoamine stimulus (GO:0071868)2.22612720
160negative regulation of T-helper cell differentiation (GO:0045623)2.20719150
161negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.20719150
162negative regulation of leukocyte mediated immunity (GO:0002704)2.20511388
163negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.19361338
164dosage compensation (GO:0007549)2.18864687
165T cell migration (GO:0072678)2.18551066
166negative regulation of glycoprotein biosynthetic process (GO:0010561)2.16300877
167pericardium development (GO:0060039)2.14482761
168cytoplasmic mRNA processing body assembly (GO:0033962)2.13407139
169detection of other organism (GO:0098543)2.11186867
170regulation of B cell differentiation (GO:0045577)2.10415229
171cellular response to ethanol (GO:0071361)2.09502744
172protein targeting to Golgi (GO:0000042)2.09003729
173negative regulation of erythrocyte differentiation (GO:0045647)2.08431377
174cell migration in hindbrain (GO:0021535)2.08007840
175protein dealkylation (GO:0008214)2.07856491
176protein demethylation (GO:0006482)2.07856491
177retrograde transport, vesicle recycling within Golgi (GO:0000301)2.07509065
178regulation of necroptotic process (GO:0060544)2.06487274
179glycoprotein catabolic process (GO:0006516)2.04575264
180nucleus localization (GO:0051647)2.03338416
181positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.03131776
182establishment of protein localization to Golgi (GO:0072600)2.02809581
183negative regulation of cAMP-mediated signaling (GO:0043951)2.02638736
184response to fluid shear stress (GO:0034405)2.01763677
185modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.01382358
186positive regulation by organism of defense response of other organism involved in symbiotic interact2.01382358
187modulation by symbiont of host immune response (GO:0052553)2.01382358
188positive regulation by symbiont of host defense response (GO:0052509)2.01382358
189modulation by symbiont of host defense response (GO:0052031)2.01382358
190modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.01382358
191regulation of ARF GTPase activity (GO:0032312)2.01365773
192regulation of dendritic cell antigen processing and presentation (GO:0002604)2.01288348
193cellular response to fluid shear stress (GO:0071498)2.01057320
194regulation of transforming growth factor beta2 production (GO:0032909)2.01022109
195positive regulation of fibroblast migration (GO:0010763)2.00887432
196positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)1.98721417
197lipid translocation (GO:0034204)1.97936946
198phospholipid translocation (GO:0045332)1.97936946
199negative regulation of type 2 immune response (GO:0002829)1.97000236
200regulation of fibroblast apoptotic process (GO:2000269)1.96788404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.40524201
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.74650060
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.40854592
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.31630806
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.64464068
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58684784
7EZH2_22144423_ChIP-Seq_EOC_Human2.57160220
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.52646431
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.52030132
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.43232621
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36440752
12RUNX_20019798_ChIP-Seq_JUKART_Human2.32958567
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.20946338
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.17686205
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14365108
16DROSHA_22980978_ChIP-Seq_HELA_Human2.10072228
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.06017934
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.01989805
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95111467
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94420007
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.87467814
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83226625
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83033606
24* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82216701
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82047381
26KDM2B_26808549_Chip-Seq_DND41_Human1.69500759
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67774551
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66959276
29TCF7_22412390_ChIP-Seq_EML_Mouse1.65990653
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64512292
31* IRF8_27001747_Chip-Seq_BMDM_Mouse1.64423735
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63841991
33GATA1_22025678_ChIP-Seq_K562_Human1.62750763
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61410395
35* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59804130
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55648222
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54998466
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53965498
39MYC_22102868_ChIP-Seq_BL_Human1.53380803
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53192961
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.51009184
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49054234
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49054234
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46353227
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.46234408
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45207259
47GBX2_23144817_ChIP-Seq_PC3_Human1.44583579
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44318575
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.42357773
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.42085847
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40689686
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39659295
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39621192
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37838580
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36509475
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35740596
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35667963
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35603893
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.33418528
60TBX20_22328084_ChIP-Seq_HEART_Mouse1.32672614
61TBX20_22080862_ChIP-Seq_HEART_Mouse1.32672614
62* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32618132
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32559482
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31816838
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30726406
66REST_21632747_ChIP-Seq_MESCs_Mouse1.27826358
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.27642778
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27590605
69MYB_26560356_Chip-Seq_TH2_Human1.27229847
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.25905026
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24161779
72SPI1_23127762_ChIP-Seq_K562_Human1.23833360
73VDR_24787735_ChIP-Seq_THP-1_Human1.23829133
74* UTX_26944678_Chip-Seq_JUKART_Human1.23776552
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23719004
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23168676
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.21230051
78* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21008997
79MAF_26560356_Chip-Seq_TH1_Human1.20258383
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18407269
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.16801725
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.16469109
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15226014
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15184055
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15105748
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.14788656
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.13999351
88* MYB_26560356_Chip-Seq_TH1_Human1.13529698
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13423728
90TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13359989
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10092486
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.08724731
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06476008
94TP53_16413492_ChIP-PET_HCT116_Human1.06396296
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06214101
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05739441
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.05156405
98* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04502390
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04407096
100KDM2B_26808549_Chip-Seq_K562_Human1.02515629
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02511810
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01720280
103LXR_22292898_ChIP-Seq_THP-1_Human1.01643095
104ZNF274_21170338_ChIP-Seq_K562_Hela1.01117900
105GATA3_27048872_Chip-Seq_THYMUS_Human1.01083088
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00188800
107VDR_24763502_ChIP-Seq_THP-1_Human0.99391485
108CTCF_27219007_Chip-Seq_Bcells_Human0.99255062
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98653187
110RUNX1_22412390_ChIP-Seq_EML_Mouse0.98142181
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97502222
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96688184
113SMAD4_21799915_ChIP-Seq_A2780_Human0.96662880
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94773318
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.94733111
116EZH2_27304074_Chip-Seq_ESCs_Mouse0.94574631
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94556699
118AR_19668381_ChIP-Seq_PC3_Human0.93819481
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93389721
120IRF8_21731497_ChIP-ChIP_J774_Mouse0.92996348
121AHR_22903824_ChIP-Seq_MCF-7_Human0.91662464
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90789111
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90383036
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90246716
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89962049
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89624313
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.89102107
128PU_27001747_Chip-Seq_BMDM_Mouse0.88810769
129* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88655047
130* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88290334
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88178451
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.87895372
133CLOCK_20551151_ChIP-Seq_293T_Human0.87869017
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87636991
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87514791
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.86797691
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86788409
138SMC4_20622854_ChIP-Seq_HELA_Human0.86675619
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.86489702
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85374949
141IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85191423
142SALL1_21062744_ChIP-ChIP_HESCs_Human0.85035148
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84728123
144ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84635105
145KLF4_19829295_ChIP-Seq_ESCs_Human0.83502495
146BCAT_22108803_ChIP-Seq_LS180_Human0.82881962
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82795881
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82297050
149EED_16625203_ChIP-ChIP_MESCs_Mouse0.81685814
150AR_25329375_ChIP-Seq_VCAP_Human0.81630985
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.81569659
152PIAS1_25552417_ChIP-Seq_VCAP_Human0.80802025
153GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80586240
154EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80026310
155MAF_26560356_Chip-Seq_TH2_Human0.79676630
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79170989
157CBP_20019798_ChIP-Seq_JUKART_Human0.79016372
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79016372
159NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78397157
160NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78397157
161MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77905958
162RXR_22108803_ChIP-Seq_LS180_Human0.77402038
163IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76531281
164ZNF263_19887448_ChIP-Seq_K562_Human0.76215112
165PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75887570
166* SMAD3_21741376_ChIP-Seq_HESCs_Human0.75288078
167PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.73802056
168TET1_21490601_ChIP-Seq_MESCs_Mouse0.72922986
169RING1B_27294783_Chip-Seq_ESCs_Mouse0.71921648
170PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.71344388
171GATA1_19941826_ChIP-Seq_K562_Human0.71152455
172AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.71040343
173STAT3_23295773_ChIP-Seq_U87_Human0.70859027
174EGR1_19032775_ChIP-ChIP_M12_Human0.70828560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.43177050
2MP0003763_abnormal_thymus_physiology3.19456971
3MP0002837_dystrophic_cardiac_calcinosis3.13844798
4MP0002139_abnormal_hepatobiliary_system3.05578170
5MP0004130_abnormal_muscle_cell3.02502068
6MP0000751_myopathy2.98727568
7MP0003436_decreased_susceptibility_to2.87506913
8MP0005365_abnormal_bile_salt2.81184276
9MP0005670_abnormal_white_adipose2.76005473
10MP0004859_abnormal_synaptic_plasticity2.57700543
11MP0005085_abnormal_gallbladder_physiolo2.53999863
12MP0005360_urolithiasis2.53970512
13MP0003091_abnormal_cell_migration2.40432989
14MP0004036_abnormal_muscle_relaxation2.38518871
15MP0000749_muscle_degeneration2.38375803
16MP0004043_abnormal_pH_regulation2.34590894
17MP0004145_abnormal_muscle_electrophysio2.34575643
18MP0003303_peritoneal_inflammation2.31561286
19MP0002822_catalepsy2.27709113
20MP0002009_preneoplasia2.27381347
21MP0002909_abnormal_adrenal_gland2.24671474
22MP0003724_increased_susceptibility_to2.23552431
23MP0001800_abnormal_humoral_immune2.19169923
24MP0009780_abnormal_chondrocyte_physiolo2.17643786
25MP0003279_aneurysm2.15165803
26MP0004510_myositis2.01759985
27MP0004084_abnormal_cardiac_muscle1.99459070
28MP0003828_pulmonary_edema1.99388557
29MP0008961_abnormal_basal_metabolism1.93389863
30MP0008260_abnormal_autophagy1.91172608
31MP0005666_abnormal_adipose_tissue1.91005978
32MP0005387_immune_system_phenotype1.90137679
33MP0001790_abnormal_immune_system1.90137679
34MP0005332_abnormal_amino_acid1.89403042
35MP0004215_abnormal_myocardial_fiber1.88356578
36MP0003252_abnormal_bile_duct1.86929680
37MP0001835_abnormal_antigen_presentation1.86097592
38MP0003195_calcinosis1.85652151
39MP0005083_abnormal_biliary_tract1.78716956
40MP0008438_abnormal_cutaneous_collagen1.78701045
41MP0010329_abnormal_lipoprotein_level1.72525555
42MP0000747_muscle_weakness1.72280711
43MP0004087_abnormal_muscle_fiber1.71755150
44MP0005620_abnormal_muscle_contractility1.69234281
45MP0005535_abnormal_body_temperature1.68660162
46MP0001765_abnormal_ion_homeostasis1.66457069
47MP0002269_muscular_atrophy1.65004831
48MP0003705_abnormal_hypodermis_morpholog1.62698130
49MP0005000_abnormal_immune_tolerance1.61900431
50MP0005409_darkened_coat_color1.61313685
51MP0002420_abnormal_adaptive_immunity1.60320976
52MP0005330_cardiomyopathy1.58623321
53MP0002723_abnormal_immune_serum1.57917085
54MP0001819_abnormal_immune_cell1.56671184
55MP0001666_abnormal_nutrient_absorption1.56133043
56MP0002452_abnormal_antigen_presenting1.53789762
57MP0000013_abnormal_adipose_tissue1.53485546
58MP0003566_abnormal_cell_adhesion1.51643012
59MP0003866_abnormal_defecation1.50718376
60MP0004233_abnormal_muscle_weight1.50591491
61MP0002118_abnormal_lipid_homeostasis1.46007136
62MP0005451_abnormal_body_composition1.43629995
63MP0000767_abnormal_smooth_muscle1.43527101
64MP0008875_abnormal_xenobiotic_pharmacok1.43007741
65MP0006036_abnormal_mitochondrial_physio1.42254019
66MP0005375_adipose_tissue_phenotype1.41573079
67MP0001851_eye_inflammation1.41436649
68MP0000685_abnormal_immune_system1.39925051
69MP0003283_abnormal_digestive_organ1.39563984
70MP0002933_joint_inflammation1.39236662
71MP0002419_abnormal_innate_immunity1.38657141
72MP0010155_abnormal_intestine_physiology1.37188311
73MP0003635_abnormal_synaptic_transmissio1.35018208
74MP0001533_abnormal_skeleton_physiology1.34759115
75MP0002078_abnormal_glucose_homeostasis1.34322993
76MP0009643_abnormal_urine_homeostasis1.33913470
77MP0002106_abnormal_muscle_physiology1.33721247
78MP0002971_abnormal_brown_adipose1.32545417
79MP0005584_abnormal_enzyme/coenzyme_acti1.31267903
80MP0004947_skin_inflammation1.31075841
81MP0005671_abnormal_response_to1.31050304
82MP0003787_abnormal_imprinting1.30460427
83MP0000759_abnormal_skeletal_muscle1.28433500
84MP0008775_abnormal_heart_ventricle1.27040615
85MP0000778_abnormal_nervous_system1.26761238
86MP0005025_abnormal_response_to1.26757692
87MP0002398_abnormal_bone_marrow1.26728101
88MP0002405_respiratory_system_inflammati1.26304053
89MP0004270_analgesia1.26141467
90MP0002998_abnormal_bone_remodeling1.25887193
91MP0003221_abnormal_cardiomyocyte_apopto1.25251209
92MP0005076_abnormal_cell_differentiation1.24794618
93MP0002972_abnormal_cardiac_muscle1.23253242
94MP0000716_abnormal_immune_system1.22394656
95MP0000703_abnormal_thymus_morphology1.22060068
96MP0003183_abnormal_peptide_metabolism1.20675549
97MP0005319_abnormal_enzyme/_coenzyme1.20231910
98MP0000230_abnormal_systemic_arterial1.16870461
99MP0010386_abnormal_urinary_bladder1.15391585
100MP0001756_abnormal_urination1.15320347
101MP0004085_abnormal_heartbeat1.14928836
102MP0005369_muscle_phenotype1.13413937
103MP0004019_abnormal_vitamin_homeostasis1.12850616
104MP0004185_abnormal_adipocyte_glucose1.11904578
105MP0000003_abnormal_adipose_tissue1.10331849
106MP0003879_abnormal_hair_cell1.09884644
107MP0003137_abnormal_impulse_conducting1.09398871
108MP0003045_fibrosis1.08699422
109MP0000465_gastrointestinal_hemorrhage1.08245515
110MP0005310_abnormal_salivary_gland1.07704503
111MP0002876_abnormal_thyroid_physiology1.07496820
112MP0003300_gastrointestinal_ulcer1.07475883
113MP0009384_cardiac_valve_regurgitation1.05089625
114MP0000689_abnormal_spleen_morphology1.02792378
115MP0004484_altered_response_of1.02355941
116MP0009745_abnormal_behavioral_response1.01175972
117MP0005334_abnormal_fat_pad0.99729747
118MP0005636_abnormal_mineral_homeostasis0.99627792
119MP0008004_abnormal_stomach_pH0.98296131
120MP0003172_abnormal_lysosome_physiology0.97586236
121MP0010352_gastrointestinal_tract_polyps0.97358609
122MP0009046_muscle_twitch0.96959056
123MP0002063_abnormal_learning/memory/cond0.96427251
124MP0003122_maternal_imprinting0.96287176
125MP0001873_stomach_inflammation0.95302651
126MP0002722_abnormal_immune_system0.94782006
127MP0000733_abnormal_muscle_development0.93351986
128MP0004808_abnormal_hematopoietic_stem0.92481841
129MP0005248_abnormal_Harderian_gland0.92011193
130MP0003868_abnormal_feces_composition0.91482933
131MP0001544_abnormal_cardiovascular_syste0.91176699
132MP0005385_cardiovascular_system_phenoty0.91176699
133MP0003953_abnormal_hormone_level0.91009115
134MP0000750_abnormal_muscle_regeneration0.90670428
135MP0003191_abnormal_cellular_cholesterol0.90627026
136MP0000604_amyloidosis0.88613905
137MP0004858_abnormal_nervous_system0.88412941
138MP0005646_abnormal_pituitary_gland0.88266847
139MP0003329_amyloid_beta_deposits0.88023472
140MP0005448_abnormal_energy_balance0.87637302
141MP0010630_abnormal_cardiac_muscle0.87376665
142MP0000462_abnormal_digestive_system0.87319744
143MP0005388_respiratory_system_phenotype0.86602077
144MP0002133_abnormal_respiratory_system0.86602077
145MP0002735_abnormal_chemical_nociception0.86461212
146MP0001849_ear_inflammation0.86180371
147MP0003633_abnormal_nervous_system0.86127444
148MP0000609_abnormal_liver_physiology0.84147456
149MP0002429_abnormal_blood_cell0.83717919
150MP0001348_abnormal_lacrimal_gland0.83704592
151MP0001968_abnormal_touch/_nociception0.83204393
152MP0003890_abnormal_embryonic-extraembry0.82805468
153MP0002925_abnormal_cardiovascular_devel0.81842743
154MP0003959_abnormal_lean_body0.81698224
155MP0008569_lethality_at_weaning0.81069400
156MP0009785_altered_susceptibility_to0.80628288
157MP0005381_digestive/alimentary_phenotyp0.80362296
158MP0004883_abnormal_blood_vessel0.80098807
159MP0002138_abnormal_hepatobiliary_system0.79880416
160MP0006138_congestive_heart_failure0.79875411
161MP0005058_abnormal_lysosome_morphology0.79687602
162MP0004272_abnormal_basement_membrane0.78992074
163MP0006035_abnormal_mitochondrial_morpho0.77855590
164MP0004147_increased_porphyrin_level0.77612018
165MP0002168_other_aberrant_phenotype0.77067293
166MP0002064_seizures0.76705166
167MP0001845_abnormal_inflammatory_respons0.76324221
168MP0001502_abnormal_circadian_rhythm0.76143865
169MP0002108_abnormal_muscle_morphology0.73130814
170MP0000569_abnormal_digit_pigmentation0.72142012
171MP0005275_abnormal_skin_tensile0.71755061
172MP0003448_altered_tumor_morphology0.71732188
173MP0001501_abnormal_sleep_pattern0.71566236
174MP0002928_abnormal_bile_duct0.71486032
175MP0005390_skeleton_phenotype0.71272220
176MP0002734_abnormal_mechanical_nocicepti0.71038002
177MP0000858_altered_metastatic_potential0.70020493
178MP0005621_abnormal_cell_physiology0.69548576
179MP0001663_abnormal_digestive_system0.69465635
180MP0001958_emphysema0.69162125
181MP0005464_abnormal_platelet_physiology0.69004941
182MP0002166_altered_tumor_susceptibility0.68634460
183MP0002396_abnormal_hematopoietic_system0.66753313

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.05150035
2Myoglobinuria (HP:0002913)4.60137640
3Ketoacidosis (HP:0001993)4.16578844
4Exercise-induced muscle cramps (HP:0003710)3.92745611
5Ketosis (HP:0001946)3.85150033
6Gout (HP:0001997)3.69017467
7Eczematoid dermatitis (HP:0000976)3.61064598
8Hyperglycinuria (HP:0003108)3.57650575
9Calf muscle hypertrophy (HP:0008981)3.57576499
10Muscle hypertrophy of the lower extremities (HP:0008968)3.41021544
11Hypoglycemic coma (HP:0001325)3.32260036
12Sudden death (HP:0001699)3.29957948
13Arterial tortuosity (HP:0005116)3.11640279
14Asymmetric septal hypertrophy (HP:0001670)3.00191962
15Abnormality of fatty-acid metabolism (HP:0004359)2.99095380
16Bundle branch block (HP:0011710)2.98814566
17T lymphocytopenia (HP:0005403)2.97505350
18Mitral valve prolapse (HP:0001634)2.95965851
19Hyporeflexia of lower limbs (HP:0002600)2.92094651
20Difficulty running (HP:0009046)2.90822225
21Abnormality of glycine metabolism (HP:0010895)2.88422051
22Abnormality of serine family amino acid metabolism (HP:0010894)2.88422051
23Aortic dissection (HP:0002647)2.86633452
24Papilledema (HP:0001085)2.84664774
25Increased circulating renin level (HP:0000848)2.83098856
26Vascular tortuosity (HP:0004948)2.82980006
27Rhabdomyolysis (HP:0003201)2.80057575
28Aortic aneurysm (HP:0004942)2.79464188
29Cervical subluxation (HP:0003308)2.75523153
30Proximal tubulopathy (HP:0000114)2.74032070
31Peritonitis (HP:0002586)2.68068110
32Abnormality of the calf musculature (HP:0001430)2.67548925
33Hyperammonemia (HP:0001987)2.67436645
34Hyperuricemia (HP:0002149)2.67289549
35Increased purine levels (HP:0004368)2.67289549
36Muscle fiber inclusion bodies (HP:0100299)2.67095234
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63247365
38Generalized aminoaciduria (HP:0002909)2.63131421
39Type 1 muscle fiber predominance (HP:0003803)2.60670636
40Prolonged QT interval (HP:0001657)2.57410731
41Facial diplegia (HP:0001349)2.53599925
42Hyperkalemia (HP:0002153)2.51013172
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.49038714
44Abnormality of the fingertips (HP:0001211)2.48817908
45Dilatation of the ascending aorta (HP:0005111)2.48351836
46Central scotoma (HP:0000603)2.48191595
47Abnormality of T cell number (HP:0011839)2.47508668
48Muscle stiffness (HP:0003552)2.45975325
49Abnormality of purine metabolism (HP:0004352)2.43779310
50Spondylolisthesis (HP:0003302)2.42812568
51Syringomyelia (HP:0003396)2.40305273
52Spinal cord lesions (HP:0100561)2.40305273
53Spontaneous hematomas (HP:0007420)2.38014673
54Dicarboxylic aciduria (HP:0003215)2.37916041
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37916041
56Ventricular fibrillation (HP:0001663)2.37897618
57EMG: myopathic abnormalities (HP:0003458)2.37173278
58Muscle fiber splitting (HP:0003555)2.36398234
59Cerebral aneurysm (HP:0004944)2.35308688
60Atrial fibrillation (HP:0005110)2.34272638
61Heart block (HP:0012722)2.33743866
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.32756495
63Hematochezia (HP:0002573)2.30890662
64Syncope (HP:0001279)2.29039946
65Hyperglycinemia (HP:0002154)2.28524824
66Increased connective tissue (HP:0009025)2.23949671
67Protrusio acetabuli (HP:0003179)2.23586319
68Hydroxyprolinuria (HP:0003080)2.21629726
69Abnormality of proline metabolism (HP:0010907)2.21629726
70Broad face (HP:0000283)2.19322959
71Obstructive sleep apnea (HP:0002870)2.19293357
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.19239921
73Dislocated radial head (HP:0003083)2.17919353
74Atrophic scars (HP:0001075)2.17240903
75Overgrowth (HP:0001548)2.16739016
76Distal arthrogryposis (HP:0005684)2.15773549
77Nemaline bodies (HP:0003798)2.15523255
78Recurrent bacterial skin infections (HP:0005406)2.14211497
79Gingivitis (HP:0000230)2.14149893
80Abnormal atrioventricular conduction (HP:0005150)2.14070479
81Atrioventricular block (HP:0001678)2.14034630
82Vitreoretinal degeneration (HP:0000655)2.13484569
83Myopathic facies (HP:0002058)2.13425399
84Palpitations (HP:0001962)2.13003242
85Primary atrial arrhythmia (HP:0001692)2.12692876
86Narrow palate (HP:0000189)2.11032574
87Ventricular arrhythmia (HP:0004308)2.10590171
88Myotonia (HP:0002486)2.10523714
89Disproportionate tall stature (HP:0001519)2.10436239
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.10065875
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09078522
92Abnormal EKG (HP:0003115)2.08405375
93Hyperinsulinemic hypoglycemia (HP:0000825)2.08059316
94Abnormality of potassium homeostasis (HP:0011042)2.06487554
95Abnormality of the left ventricular outflow tract (HP:0011103)2.05104208
96Subaortic stenosis (HP:0001682)2.05104208
97Recurrent fungal infections (HP:0002841)2.03545658
98Subacute progressive viral hepatitis (HP:0006572)2.01434142
99Ventricular tachycardia (HP:0004756)2.01409322
100Aneurysm (HP:0002617)2.00902895
101Gastrointestinal infarctions (HP:0005244)2.00703682
102Thin bony cortex (HP:0002753)1.99450266
103Supraventricular tachycardia (HP:0004755)1.97486436
104Dysmetric saccades (HP:0000641)1.97140060
105Recurrent cutaneous fungal infections (HP:0011370)1.96780044
106Chronic mucocutaneous candidiasis (HP:0002728)1.96780044
107Hypoalphalipoproteinemia (HP:0003233)1.96612877
108Recurrent abscess formation (HP:0002722)1.96383703
109Abnormality of renin-angiotensin system (HP:0000847)1.96367912
110Abnormality of the radial head (HP:0003995)1.95598792
111Heterotopia (HP:0002282)1.94650127
112Metabolic acidosis (HP:0001942)1.93974622
113Mediastinal lymphadenopathy (HP:0100721)1.92947442
114Neonatal onset (HP:0003623)1.92915541
115Difficulty climbing stairs (HP:0003551)1.92853432
116Abnormality of macrophages (HP:0004311)1.92763164
117Absent frontal sinuses (HP:0002688)1.92301555
118Supraventricular arrhythmia (HP:0005115)1.92279241
119Impaired social interactions (HP:0000735)1.92169842
120Abnormal social behavior (HP:0012433)1.92169842
121Focal motor seizures (HP:0011153)1.91724147
122Ulnar deviation of the wrist (HP:0003049)1.91402530
123Myositis (HP:0100614)1.91293377
124Broad palm (HP:0001169)1.90227829
125Broad ribs (HP:0000885)1.89722125
126Frequent falls (HP:0002359)1.88694901
127Postural instability (HP:0002172)1.88158993
128Xanthomatosis (HP:0000991)1.87269184
129Increased variability in muscle fiber diameter (HP:0003557)1.86665333
130Pustule (HP:0200039)1.86324217
131Visual hallucinations (HP:0002367)1.85377991
132Thoracolumbar scoliosis (HP:0002944)1.85350780
133Hypokalemia (HP:0002900)1.84994296
134Right ventricular cardiomyopathy (HP:0011663)1.83876234
135Dilated cardiomyopathy (HP:0001644)1.83838641
136Genu recurvatum (HP:0002816)1.83555636
137Bicuspid aortic valve (HP:0001647)1.81730863
138Lipoatrophy (HP:0100578)1.81149943
139Abnormality of renal excretion (HP:0011036)1.80941745
140Long toe (HP:0010511)1.80339846
141Poor eye contact (HP:0000817)1.80334948
142Hypoglycemic seizures (HP:0002173)1.79836482
143Abnormal urine output (HP:0012590)1.79751315
144Cellulitis (HP:0100658)1.79660860
145Insulin-resistant diabetes mellitus (HP:0000831)1.78741415
146Lymphangioma (HP:0100764)1.77780260
147Hyperactive renin-angiotensin system (HP:0000841)1.77503393
148Hyperaldosteronism (HP:0000859)1.75737476
149Late onset (HP:0003584)1.75726741
150Sensorimotor neuropathy (HP:0007141)1.74160278
151Abnormality of skeletal muscle fiber size (HP:0012084)1.74113972
152Generalized muscle weakness (HP:0003324)1.73342355
153Premature rupture of membranes (HP:0001788)1.73038252
154Oligomenorrhea (HP:0000876)1.72889070
155Slow saccadic eye movements (HP:0000514)1.72411852
156Mitral regurgitation (HP:0001653)1.71930976
157Joint laxity (HP:0001388)1.70408850
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70175674
159Stomatitis (HP:0010280)1.68345752
160Metaphyseal cupping (HP:0003021)1.67720849
161Optic neuritis (HP:0100653)1.66571670
162Retrobulbar optic neuritis (HP:0100654)1.66571670
163Meningitis (HP:0001287)1.65429585
164Orchitis (HP:0100796)1.64077808
165Pulmonary infiltrates (HP:0002113)1.63839313
166Abnormality of the peritoneum (HP:0002585)1.63573824
167Abnormality of the humeroradial joint (HP:0100744)1.63215079
168Neonatal hypoglycemia (HP:0001998)1.63045755
169Gastrointestinal stroma tumor (HP:0100723)1.62139987
170Supranuclear gaze palsy (HP:0000605)1.61903822
171Excessive salivation (HP:0003781)1.61854207
172Long eyelashes (HP:0000527)1.60911658
173Chest pain (HP:0100749)1.60382913
174Papilloma (HP:0012740)1.59257129
175Verrucae (HP:0200043)1.59257129
176Thickened calvaria (HP:0002684)1.58941547
177Neoplasm of the tracheobronchial system (HP:0100552)1.58892356
178Lower limb muscle weakness (HP:0007340)1.58566303
179Persistence of primary teeth (HP:0006335)1.58427993
180Leukocytosis (HP:0001974)1.57078393
181Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.56921406
182Colitis (HP:0002583)1.56767984
183Transitional cell carcinoma of the bladder (HP:0006740)1.56222839
184Vasculitis (HP:0002633)1.55214067
185Truncal obesity (HP:0001956)1.54983046
186Inflammation of the large intestine (HP:0002037)1.54725163
187Mild short stature (HP:0003502)1.53613099
188Vertebral arch anomaly (HP:0008438)1.53579173
189Recurrent bronchitis (HP:0002837)1.52925230
190Lymphopenia (HP:0001888)1.52530035
191Hip dysplasia (HP:0001385)1.52519963
192Flat acetabular roof (HP:0003180)1.52359549
193Abnormality of skull ossification (HP:0002703)1.50813126
194Recurrent viral infections (HP:0004429)1.50500625
195Genetic anticipation (HP:0003743)1.50469927
196Gastrointestinal inflammation (HP:0004386)1.50287830
197Hypoplastic nipples (HP:0002557)1.50091498
198Round face (HP:0000311)1.49431798
199Bladder neoplasm (HP:0009725)1.48943882
200Bladder carcinoma (HP:0002862)1.48943882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.21555233
2PDK33.10823140
3PDK43.10823140
4TRIB32.87608307
5PHKG22.52177218
6PHKG12.52177218
7OBSCN2.47440610
8PINK12.45846192
9TTN2.41951425
10PKN22.38745716
11MAP3K102.21815550
12PRPF4B2.21799772
13PRKD32.17133864
14MAP4K12.16067729
15NTRK32.07805770
16INSRR2.06837462
17WNK42.05716257
18LMTK21.99389646
19PDK21.93118828
20RIPK11.89815230
21TYK21.79509130
22SIK11.72203266
23DAPK21.70949681
24EPHB11.70450634
25NEK11.70120480
26STK381.68720722
27TYRO31.66337124
28ERN11.62693020
29NLK1.56832221
30CDK121.56784781
31CAMKK11.55857983
32BLK1.54750695
33MAP3K71.52293160
34BRD41.46513593
35ZAP701.44493101
36TXK1.41349418
37EPHA41.40145465
38RIPK41.36449001
39MAP2K41.35201628
40MAP3K141.35027700
41FES1.34966461
42JAK31.34454047
43MAP3K41.28852156
44ITK1.28617497
45DYRK1B1.26201838
46PIK3CG1.25500945
47SIK31.23422465
48CAMK1G1.22891157
49MAP3K91.20266078
50BTK1.20001925
51KSR11.18092079
52CSK1.15634081
53PASK1.13422739
54PDGFRB1.11779111
55MARK11.10233659
56SGK31.07378508
57CASK1.07228365
58CAMK1D1.05567779
59DMPK1.02563069
60GRK61.01820888
61IRAK41.01641530
62TIE11.00030352
63PRKCH0.99796618
64WNK30.97628440
65PDK10.97391150
66PAK60.97009546
67FGR0.94876356
68KSR20.94671211
69HCK0.93296386
70SYK0.93116490
71PRKAA10.91794882
72MYLK0.90781088
73JAK10.90402584
74PDPK10.89325008
75MINK10.88583031
76LCK0.88173298
77PRKD20.87839464
78RET0.87782911
79CAMKK20.84405316
80PDGFRA0.84251202
81AKT30.84201422
82SGK20.83528064
83MAP2K70.82213281
84MAPK70.81622140
85MAP3K130.81416753
86WNK10.80866254
87IKBKE0.80314322
88FLT30.80080301
89TAOK10.79342473
90PTK60.78984951
91FGFR20.77725192
92MAP3K60.77607368
93SCYL20.77268151
94PRKAA20.76609478
95TAOK30.75815075
96YES10.75105035
97STK110.74982330
98CAMK10.74813213
99SIK20.74535133
100TNK20.74298999
101UHMK10.73436008
102IRAK30.73174803
103MAPK120.73081369
104EPHB20.72259484
105MAP3K20.71870618
106FRK0.71572179
107NTRK10.71470973
108FGFR40.70914246
109PIK3CA0.70527497
110SGK2230.69853995
111SGK4940.69853995
112MAP3K10.67973917
113CDK60.67689217
114DYRK1A0.66902886
115LYN0.64390330
116CDC42BPA0.64360810
117PTK2B0.64005273
118OXSR10.63909723
119FYN0.62860207
120JAK20.61662618
121TEC0.61390420
122SGK10.58208981
123MAP2K60.57766493
124FER0.57448490
125CDK50.57124138
126ICK0.56480768
127CSF1R0.56430547
128HIPK20.56107836
129CAMK40.53229063
130EPHA30.52725676
131FGFR30.52563740
132PAK30.51836713
133TGFBR20.50053313
134MAPKAPK30.50011152
135MELK0.49401817
136MARK30.48870879
137MAP2K10.48594930
138STK390.47799523
139MAP2K30.47170346
140LATS10.45248086
141NTRK20.43194113
142MAPK110.42692324
143PRKD10.42532619
144RPS6KA20.41176013
145PRKACG0.40947426
146MUSK0.40622098
147PRKCG0.39881671
148MARK20.39352054
149RPS6KA30.39006067
150PRKCZ0.38975065

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.23083507
2Propanoate metabolism_Homo sapiens_hsa006403.04946975
3Fatty acid degradation_Homo sapiens_hsa000712.69535128
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.55827520
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51186686
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41307933
7Fatty acid metabolism_Homo sapiens_hsa012122.10705511
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08038352
9Nitrogen metabolism_Homo sapiens_hsa009102.02270391
10Butanoate metabolism_Homo sapiens_hsa006501.92205203
11B cell receptor signaling pathway_Homo sapiens_hsa046621.82326198
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75288822
13Pyruvate metabolism_Homo sapiens_hsa006201.69200223
14PPAR signaling pathway_Homo sapiens_hsa033201.68293399
15T cell receptor signaling pathway_Homo sapiens_hsa046601.66537956
16Osteoclast differentiation_Homo sapiens_hsa043801.61003890
17Tryptophan metabolism_Homo sapiens_hsa003801.54197667
18Arginine biosynthesis_Homo sapiens_hsa002201.53464787
19Carbon metabolism_Homo sapiens_hsa012001.52366577
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45656983
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41934420
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.40850064
23Chronic myeloid leukemia_Homo sapiens_hsa052201.38488143
24beta-Alanine metabolism_Homo sapiens_hsa004101.38091184
25Acute myeloid leukemia_Homo sapiens_hsa052211.35898791
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35390076
27Endometrial cancer_Homo sapiens_hsa052131.33027299
28Non-small cell lung cancer_Homo sapiens_hsa052231.32730402
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31702624
30Renal cell carcinoma_Homo sapiens_hsa052111.29019466
31Starch and sucrose metabolism_Homo sapiens_hsa005001.28982383
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.28803488
33Bile secretion_Homo sapiens_hsa049761.27795260
34Colorectal cancer_Homo sapiens_hsa052101.23746964
35Insulin secretion_Homo sapiens_hsa049111.22685581
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21970701
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21217513
38VEGF signaling pathway_Homo sapiens_hsa043701.20831703
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.20006151
40Choline metabolism in cancer_Homo sapiens_hsa052311.19940791
41Pancreatic cancer_Homo sapiens_hsa052121.19637257
42Inositol phosphate metabolism_Homo sapiens_hsa005621.19586660
43Prolactin signaling pathway_Homo sapiens_hsa049171.18868278
44Leishmaniasis_Homo sapiens_hsa051401.17647984
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16823244
46Glucagon signaling pathway_Homo sapiens_hsa049221.15901223
47Peroxisome_Homo sapiens_hsa041461.14909447
48Adherens junction_Homo sapiens_hsa045201.13822671
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.13699097
50FoxO signaling pathway_Homo sapiens_hsa040681.13057513
51Dilated cardiomyopathy_Homo sapiens_hsa054141.12834315
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12722339
53Olfactory transduction_Homo sapiens_hsa047401.10435743
54Glycerolipid metabolism_Homo sapiens_hsa005611.09576344
55Chemokine signaling pathway_Homo sapiens_hsa040621.09469004
56Fatty acid biosynthesis_Homo sapiens_hsa000611.09307281
57ErbB signaling pathway_Homo sapiens_hsa040121.07936679
58Primary immunodeficiency_Homo sapiens_hsa053401.07656373
59Synaptic vesicle cycle_Homo sapiens_hsa047211.06880690
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06743676
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06171923
62Toxoplasmosis_Homo sapiens_hsa051451.05816584
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05690498
64Other glycan degradation_Homo sapiens_hsa005111.05656874
65Pancreatic secretion_Homo sapiens_hsa049721.05420973
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05169359
67Type II diabetes mellitus_Homo sapiens_hsa049301.04700836
68Notch signaling pathway_Homo sapiens_hsa043301.04524865
69Measles_Homo sapiens_hsa051621.04116043
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03972955
71Focal adhesion_Homo sapiens_hsa045101.03494181
72Dorso-ventral axis formation_Homo sapiens_hsa043201.02955944
73TNF signaling pathway_Homo sapiens_hsa046681.00849573
74Circadian entrainment_Homo sapiens_hsa047131.00097510
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.99097637
76Insulin resistance_Homo sapiens_hsa049310.98979327
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.98915984
78ABC transporters_Homo sapiens_hsa020100.98878980
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98205846
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97986764
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97900653
82Gastric acid secretion_Homo sapiens_hsa049710.97554428
83Hepatitis B_Homo sapiens_hsa051610.97440406
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96382017
85Cardiac muscle contraction_Homo sapiens_hsa042600.96037563
86Salivary secretion_Homo sapiens_hsa049700.95477576
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95259017
88Platelet activation_Homo sapiens_hsa046110.95251026
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.94268862
90Amoebiasis_Homo sapiens_hsa051460.93563610
91Renin secretion_Homo sapiens_hsa049240.93412561
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93309588
93Lysine degradation_Homo sapiens_hsa003100.92938151
94Tuberculosis_Homo sapiens_hsa051520.90481283
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90138014
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89557759
97Small cell lung cancer_Homo sapiens_hsa052220.88685715
98Glioma_Homo sapiens_hsa052140.88493519
99Prostate cancer_Homo sapiens_hsa052150.87645155
100Proteoglycans in cancer_Homo sapiens_hsa052050.87315654
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86621514
102Calcium signaling pathway_Homo sapiens_hsa040200.85288040
103MAPK signaling pathway_Homo sapiens_hsa040100.84860720
104GABAergic synapse_Homo sapiens_hsa047270.84017634
105Insulin signaling pathway_Homo sapiens_hsa049100.83431258
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83162548
107Axon guidance_Homo sapiens_hsa043600.82946918
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82711977
109Fat digestion and absorption_Homo sapiens_hsa049750.81520335
110Rap1 signaling pathway_Homo sapiens_hsa040150.80724701
111Hepatitis C_Homo sapiens_hsa051600.80139919
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.80138598
113Biosynthesis of amino acids_Homo sapiens_hsa012300.79527663
114Morphine addiction_Homo sapiens_hsa050320.78303255
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78127774
116Estrogen signaling pathway_Homo sapiens_hsa049150.78111537
117Protein digestion and absorption_Homo sapiens_hsa049740.77874500
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77426616
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77066981
120Ras signaling pathway_Homo sapiens_hsa040140.76864980
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76660642
122Viral myocarditis_Homo sapiens_hsa054160.76468499
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76057122
124Oxytocin signaling pathway_Homo sapiens_hsa049210.76032742
125Hematopoietic cell lineage_Homo sapiens_hsa046400.74127488
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73852319
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.73743135
128Influenza A_Homo sapiens_hsa051640.72747596
129MicroRNAs in cancer_Homo sapiens_hsa052060.72133039
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71789983
131Endocytosis_Homo sapiens_hsa041440.70394317
132Hedgehog signaling pathway_Homo sapiens_hsa043400.70038640
133Pathways in cancer_Homo sapiens_hsa052000.68447180
134Cholinergic synapse_Homo sapiens_hsa047250.67182191
135AMPK signaling pathway_Homo sapiens_hsa041520.66071171
136Shigellosis_Homo sapiens_hsa051310.65995879
137Malaria_Homo sapiens_hsa051440.65411840
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64924323
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64864350
140Amphetamine addiction_Homo sapiens_hsa050310.64802950
141Graft-versus-host disease_Homo sapiens_hsa053320.64663391
142ECM-receptor interaction_Homo sapiens_hsa045120.64555770
143Long-term potentiation_Homo sapiens_hsa047200.63721854
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63095582
145Thyroid cancer_Homo sapiens_hsa052160.62748281
146Phenylalanine metabolism_Homo sapiens_hsa003600.62632358
147Glutamatergic synapse_Homo sapiens_hsa047240.61799128
148Gap junction_Homo sapiens_hsa045400.61763159
149Phagosome_Homo sapiens_hsa041450.61458277
150Melanogenesis_Homo sapiens_hsa049160.60741953
151Apoptosis_Homo sapiens_hsa042100.60626673
152Fructose and mannose metabolism_Homo sapiens_hsa000510.60164023
153Thyroid hormone synthesis_Homo sapiens_hsa049180.59378341
154cAMP signaling pathway_Homo sapiens_hsa040240.58033459
155Circadian rhythm_Homo sapiens_hsa047100.57986198
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56917710
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56358526
158Nicotine addiction_Homo sapiens_hsa050330.54886361
159Vascular smooth muscle contraction_Homo sapiens_hsa042700.53581547
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53034593
161Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51082396
162Cyanoamino acid metabolism_Homo sapiens_hsa004600.49700186
163Sulfur metabolism_Homo sapiens_hsa009200.49113134
164Dopaminergic synapse_Homo sapiens_hsa047280.48981585
165Galactose metabolism_Homo sapiens_hsa000520.48933016
166Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48400742
167Maturity onset diabetes of the young_Homo sapiens_hsa049500.47415495
168Arginine and proline metabolism_Homo sapiens_hsa003300.47317132
169Central carbon metabolism in cancer_Homo sapiens_hsa052300.46271314
170Taste transduction_Homo sapiens_hsa047420.43711103
171Ovarian steroidogenesis_Homo sapiens_hsa049130.41334801
172Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41118199
173GnRH signaling pathway_Homo sapiens_hsa049120.39746801
174Cocaine addiction_Homo sapiens_hsa050300.38747638
175Complement and coagulation cascades_Homo sapiens_hsa046100.38480698
176Selenocompound metabolism_Homo sapiens_hsa004500.35019517
177Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33959958
178Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33782592
179Steroid hormone biosynthesis_Homo sapiens_hsa001400.31119267
180mTOR signaling pathway_Homo sapiens_hsa041500.31060030

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