ENTPD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.35565158
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.81937436
3L-phenylalanine catabolic process (GO:0006559)6.81937436
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.56031982
5L-phenylalanine metabolic process (GO:0006558)6.56031982
6aromatic amino acid family catabolic process (GO:0009074)6.20833978
7glyoxylate metabolic process (GO:0046487)5.81629140
8omega-hydroxylase P450 pathway (GO:0097267)5.76146098
9tryptophan catabolic process (GO:0006569)5.65584439
10indole-containing compound catabolic process (GO:0042436)5.65584439
11indolalkylamine catabolic process (GO:0046218)5.65584439
12cysteine metabolic process (GO:0006534)5.56656007
13lysine catabolic process (GO:0006554)5.55385979
14lysine metabolic process (GO:0006553)5.55385979
15kynurenine metabolic process (GO:0070189)5.51907892
16tryptophan metabolic process (GO:0006568)5.29805411
17alpha-linolenic acid metabolic process (GO:0036109)5.27259474
18bile acid biosynthetic process (GO:0006699)5.27143722
19sulfur amino acid catabolic process (GO:0000098)5.25494746
20very-low-density lipoprotein particle assembly (GO:0034379)5.23317706
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.18520860
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.17841117
23fibrinolysis (GO:0042730)4.96105558
24amino-acid betaine metabolic process (GO:0006577)4.85344161
25homocysteine metabolic process (GO:0050667)4.76145497
26ethanol oxidation (GO:0006069)4.73473562
27intestinal absorption (GO:0050892)4.71562814
28blood coagulation, intrinsic pathway (GO:0007597)4.71395601
29cellular ketone body metabolic process (GO:0046950)4.69630420
30urea metabolic process (GO:0019627)4.67128116
31urea cycle (GO:0000050)4.67128116
32fat-soluble vitamin biosynthetic process (GO:0042362)4.66704080
33serine family amino acid catabolic process (GO:0009071)4.65964769
34drug transmembrane transport (GO:0006855)4.54133501
35phenylpropanoid metabolic process (GO:0009698)4.52788902
36cellular glucuronidation (GO:0052695)4.52771048
37bile acid metabolic process (GO:0008206)4.51406144
38aromatic amino acid family metabolic process (GO:0009072)4.46999149
39oxidative demethylation (GO:0070989)4.43728943
40high-density lipoprotein particle remodeling (GO:0034375)4.42191093
41short-chain fatty acid metabolic process (GO:0046459)4.40331645
42drug catabolic process (GO:0042737)4.40121515
43regulation of triglyceride catabolic process (GO:0010896)4.36400457
44nitrogen cycle metabolic process (GO:0071941)4.36347868
45alpha-amino acid catabolic process (GO:1901606)4.36110572
46plasma lipoprotein particle assembly (GO:0034377)4.30957022
47negative regulation of fibrinolysis (GO:0051918)4.29579556
48complement activation, alternative pathway (GO:0006957)4.28052932
49negative regulation of hemostasis (GO:1900047)4.25401772
50negative regulation of blood coagulation (GO:0030195)4.25401772
51intestinal cholesterol absorption (GO:0030299)4.24285940
52aspartate family amino acid catabolic process (GO:0009068)4.23244172
53benzene-containing compound metabolic process (GO:0042537)4.21684758
54acetyl-CoA metabolic process (GO:0006084)4.19770458
55hormone catabolic process (GO:0042447)4.19303534
56glucuronate metabolic process (GO:0019585)4.19204284
57uronic acid metabolic process (GO:0006063)4.19204284
58protein carboxylation (GO:0018214)4.16860539
59peptidyl-glutamic acid carboxylation (GO:0017187)4.16860539
60regulation of protein activation cascade (GO:2000257)4.16620547
61fatty acid beta-oxidation (GO:0006635)4.16235055
62cellular amino acid catabolic process (GO:0009063)4.14946956
63fatty acid oxidation (GO:0019395)4.12108445
64urate metabolic process (GO:0046415)4.11981727
65glutamate metabolic process (GO:0006536)4.11309860
66regulation of fibrinolysis (GO:0051917)4.08776089
67tyrosine metabolic process (GO:0006570)4.07423122
68ketone body metabolic process (GO:1902224)4.05866666
69lipid oxidation (GO:0034440)4.04251111
70regulation of plasminogen activation (GO:0010755)4.03127310
71cellular modified amino acid catabolic process (GO:0042219)4.02272035
72serine family amino acid metabolic process (GO:0009069)4.01250799
732-oxoglutarate metabolic process (GO:0006103)4.00886751
74regulation of cholesterol esterification (GO:0010872)3.98917575
75carnitine metabolic process (GO:0009437)3.97709905
76response to nitrosative stress (GO:0051409)3.97335911
77indolalkylamine metabolic process (GO:0006586)3.94356047
78flavonoid metabolic process (GO:0009812)3.93591077
79acylglycerol homeostasis (GO:0055090)3.91974578
80triglyceride homeostasis (GO:0070328)3.91974578
81bile acid and bile salt transport (GO:0015721)3.91931108
82alkaloid metabolic process (GO:0009820)3.91823139
83positive regulation of lipoprotein lipase activity (GO:0051006)3.90999827
84positive regulation of triglyceride lipase activity (GO:0061365)3.90999827
85exogenous drug catabolic process (GO:0042738)3.90800695
86regulation of complement activation (GO:0030449)3.90695825
87negative regulation of sterol transport (GO:0032372)3.89706061
88negative regulation of cholesterol transport (GO:0032375)3.89706061
89negative regulation of coagulation (GO:0050819)3.89275996
90coenzyme catabolic process (GO:0009109)3.89251614
91reverse cholesterol transport (GO:0043691)3.89120731
92protein-lipid complex assembly (GO:0065005)3.87625210
93fatty acid catabolic process (GO:0009062)3.86736781
94monocarboxylic acid catabolic process (GO:0072329)3.85422578
95plasma lipoprotein particle remodeling (GO:0034369)3.85185473
96protein-lipid complex remodeling (GO:0034368)3.85185473
97macromolecular complex remodeling (GO:0034367)3.85185473
98amine catabolic process (GO:0009310)3.84987376
99cellular biogenic amine catabolic process (GO:0042402)3.84987376
100organic acid catabolic process (GO:0016054)3.83214184
101carboxylic acid catabolic process (GO:0046395)3.83214184
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.79621288
103phospholipid efflux (GO:0033700)3.78422344
104valine metabolic process (GO:0006573)3.76911366
105negative regulation of wound healing (GO:0061045)3.75604593
106negative regulation of protein activation cascade (GO:2000258)3.75223467
107xenobiotic catabolic process (GO:0042178)3.75046623
108positive regulation of lipid catabolic process (GO:0050996)3.74292183
109drug transport (GO:0015893)3.73897043
110protein activation cascade (GO:0072376)3.73744463
111dicarboxylic acid biosynthetic process (GO:0043650)3.73646446
112arginine metabolic process (GO:0006525)3.71481920
113plasma lipoprotein particle organization (GO:0071827)3.69244616
114glycine metabolic process (GO:0006544)3.68254093
115serine family amino acid biosynthetic process (GO:0009070)3.66366285
116plasma lipoprotein particle clearance (GO:0034381)3.66042611
117aldehyde catabolic process (GO:0046185)3.63717646
118regulation of cholesterol homeostasis (GO:2000188)3.59598394
119ethanol metabolic process (GO:0006067)3.57012340
120phospholipid homeostasis (GO:0055091)3.55869558
121regulation of bile acid biosynthetic process (GO:0070857)3.55077021
122regulation of cholesterol metabolic process (GO:0090181)3.54712945
123heme transport (GO:0015886)3.54358034
124drug metabolic process (GO:0017144)3.53474199
125complement activation, classical pathway (GO:0006958)3.52013251
126protein-lipid complex subunit organization (GO:0071825)3.49349228
127response to mercury ion (GO:0046689)3.47267962
128primary alcohol catabolic process (GO:0034310)3.47102349
129polyketide metabolic process (GO:0030638)3.46939547
130doxorubicin metabolic process (GO:0044598)3.46939547
131daunorubicin metabolic process (GO:0044597)3.46939547
132lipoprotein metabolic process (GO:0042157)3.46764185
133low-density lipoprotein particle remodeling (GO:0034374)3.46463009
134branched-chain amino acid catabolic process (GO:0009083)3.46100264
135cholesterol efflux (GO:0033344)3.44394799
136negative regulation of lipase activity (GO:0060192)3.41203261
137xenobiotic metabolic process (GO:0006805)3.36384366
138positive regulation of blood coagulation (GO:0030194)3.35828957
139positive regulation of hemostasis (GO:1900048)3.35828957
140cholesterol homeostasis (GO:0042632)3.33807634
141complement activation (GO:0006956)3.29811514
142aminoglycoside antibiotic metabolic process (GO:0030647)3.28631688
143sterol homeostasis (GO:0055092)3.28298852
144acute-phase response (GO:0006953)3.27647301
145regulation of humoral immune response (GO:0002920)3.25073220
146S-adenosylmethionine metabolic process (GO:0046500)3.23921021
147angiotensin maturation (GO:0002003)3.18502837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.53689899
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.53869824
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.97101900
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.81901641
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.61356070
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.56357726
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.12553338
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74741451
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.21077708
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44427171
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05172836
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4861409
13* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95790887
14CLOCK_20551151_ChIP-Seq_293T_Human1.90882712
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69837497
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.69665342
17TCF4_18268006_ChIP-ChIP_LS174T_Human1.62691677
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49804670
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48289848
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39344205
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34485611
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.30327025
23GATA1_22025678_ChIP-Seq_K562_Human1.29740481
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.27029893
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23031877
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20603013
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20119135
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18887960
29GATA4_25053715_ChIP-Seq_YYC3_Human1.14235681
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13654279
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07864779
32HTT_18923047_ChIP-ChIP_STHdh_Human1.07430545
33ZNF263_19887448_ChIP-Seq_K562_Human1.06966884
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05484416
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05346299
36AR_21909140_ChIP-Seq_LNCAP_Human1.04694396
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.02238945
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98987609
39ESR1_21235772_ChIP-Seq_MCF-7_Human0.97432531
40CDX2_20551321_ChIP-Seq_CACO-2_Human0.93366412
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93117037
42IRF8_22096565_ChIP-ChIP_GC-B_Human0.91273795
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90948280
44RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89066318
45CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88636932
46FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88202980
47* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87614345
48* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87614345
49PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87342650
50FOXO3_23340844_ChIP-Seq_DLD1_Human0.86834019
51PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85876920
52AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84501319
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82014446
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81783384
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81031920
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80973768
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80751409
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80457703
59SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77412221
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77136237
61TP63_17297297_ChIP-ChIP_HaCaT_Human0.76872159
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76436182
63GATA1_19941826_ChIP-Seq_K562_Human0.75766655
64TBX20_22328084_ChIP-Seq_HEART_Mouse0.75077758
65TBX20_22080862_ChIP-Seq_HEART_Mouse0.75077758
66HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74203408
67TP53_16413492_ChIP-PET_HCT116_Human0.73579533
68TP63_23658742_ChIP-Seq_EP156T_Human0.73309580
69GATA2_19941826_ChIP-Seq_K562_Human0.73133526
70* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72985744
71FOXA1_25552417_ChIP-Seq_VCAP_Human0.72616304
72EGR1_19032775_ChIP-ChIP_M12_Human0.72410743
73CJUN_26792858_Chip-Seq_BT549_Human0.72244899
74ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71579319
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71523916
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71478858
77GATA6_25053715_ChIP-Seq_YYC3_Human0.70721119
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69718540
79SOX2_20726797_ChIP-Seq_SW620_Human0.69112797
80NFE2_27457419_Chip-Seq_LIVER_Mouse0.68746554
81P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68735828
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66826254
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66822475
84CEBPB_22108803_ChIP-Seq_LS180_Human0.65476630
85HNFA_21074721_ChIP-Seq_CACO-2_Human0.65470670
86RXR_22108803_ChIP-Seq_LS180_Human0.64819135
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.64770686
88ER_23166858_ChIP-Seq_MCF-7_Human0.64614881
89AHR_22903824_ChIP-Seq_MCF-7_Human0.64199909
90SOX9_24532713_ChIP-Seq_HFSC_Mouse0.63869362
91PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.63819635
92LXR_22292898_ChIP-Seq_THP-1_Human0.63489161
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63215179
94RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62665535
95TRIM28_21343339_ChIP-Seq_HEK293_Human0.62578479
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61784814
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61485543
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61170745
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60893897
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.59134758
101RACK7_27058665_Chip-Seq_MCF-7_Human0.59130367
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.58428047
103RARA_24833708_ChIP-Seq_LIVER_Mouse0.55959649
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.55311305
105GATA2_21666600_ChIP-Seq_HMVEC_Human0.55283329
106MYC_19915707_ChIP-ChIP_AK7_Human0.55174958
107CBP_21632823_ChIP-Seq_H3396_Human0.54290434
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.52876113
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.52620701
110AR_20517297_ChIP-Seq_VCAP_Human0.52511191
111ESET_19884257_ChIP-Seq_ESCs_Mouse0.52461020
112* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52384232
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.51551743
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.50936612
115FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50901528
116BCAT_22108803_ChIP-Seq_LS180_Human0.50855853
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.50188045
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.48556549
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.48441181
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.48373011
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.47750463
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.47745244
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.47311665
124CDX2_22108803_ChIP-Seq_LS180_Human0.46829591
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45215135
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45034331
127STAT1_17558387_ChIP-Seq_HELA_Human0.44980006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.61616612
2MP0005360_urolithiasis7.48525097
3MP0005085_abnormal_gallbladder_physiolo5.76413031
4MP0005365_abnormal_bile_salt5.66325536
5MP0008875_abnormal_xenobiotic_pharmacok5.46608650
6MP0003806_abnormal_nucleotide_metabolis3.86402334
7MP0003252_abnormal_bile_duct3.83446973
8MP0010329_abnormal_lipoprotein_level3.22169991
9MP0005332_abnormal_amino_acid3.15294688
10MP0003195_calcinosis2.94729122
11MP0009840_abnormal_foam_cell2.83791310
12MP0001666_abnormal_nutrient_absorption2.62676610
13MP0004019_abnormal_vitamin_homeostasis2.54482089
14MP0005083_abnormal_biliary_tract2.52964381
15MP0003191_abnormal_cellular_cholesterol2.31600493
16MP0002138_abnormal_hepatobiliary_system2.09940209
17* MP0002118_abnormal_lipid_homeostasis2.05406894
18* MP0000609_abnormal_liver_physiology1.96021221
19MP0009643_abnormal_urine_homeostasis1.81848600
20* MP0005319_abnormal_enzyme/_coenzyme1.79184865
21MP0005584_abnormal_enzyme/coenzyme_acti1.72563858
22MP0004043_abnormal_pH_regulation1.64883507
23MP0003868_abnormal_feces_composition1.57287621
24MP0003183_abnormal_peptide_metabolism1.50700780
25MP0005451_abnormal_body_composition1.49377200
26MP0003186_abnormal_redox_activity1.48222720
27MP0001764_abnormal_homeostasis1.45468343
28MP0005636_abnormal_mineral_homeostasis1.32212831
29MP0005670_abnormal_white_adipose1.19929138
30MP0006036_abnormal_mitochondrial_physio1.17099499
31MP0004130_abnormal_muscle_cell1.13238702
32MP0005409_darkened_coat_color1.09548659
33MP0002837_dystrophic_cardiac_calcinosis1.08559117
34MP0001756_abnormal_urination1.06768997
35MP0003656_abnormal_erythrocyte_physiolo1.03544370
36* MP0000598_abnormal_liver_morphology1.02518016
37MP0009764_decreased_sensitivity_to0.98829544
38MP0003879_abnormal_hair_cell0.96383544
39MP0000604_amyloidosis0.96062408
40MP0009697_abnormal_copulation0.95017278
41MP0003011_delayed_dark_adaptation0.92917953
42MP0002136_abnormal_kidney_physiology0.92738572
43MP0009763_increased_sensitivity_to0.89845084
44MP0005666_abnormal_adipose_tissue0.87848355
45MP0001765_abnormal_ion_homeostasis0.87836590
46MP0000566_synostosis0.87522665
47* MP0009642_abnormal_blood_homeostasis0.86504431
48MP0003866_abnormal_defecation0.86046785
49MP0010155_abnormal_intestine_physiology0.85304916
50MP0005647_abnormal_sex_gland0.85272420
51MP0005408_hypopigmentation0.85150710
52MP0001664_abnormal_digestion0.84617549
53MP0003690_abnormal_glial_cell0.84037387
54MP0002971_abnormal_brown_adipose0.83883428
55MP0005535_abnormal_body_temperature0.82373347
56* MP0008469_abnormal_protein_level0.81765403
57MP0002876_abnormal_thyroid_physiology0.79907675
58MP0010368_abnormal_lymphatic_system0.79570096
59MP0005084_abnormal_gallbladder_morpholo0.79088516
60MP0003705_abnormal_hypodermis_morpholog0.78399846
61MP0003329_amyloid_beta_deposits0.78165731
62* MP0002078_abnormal_glucose_homeostasis0.78094866
63MP0002254_reproductive_system_inflammat0.73317523
64MP0005376_homeostasis/metabolism_phenot0.73164822
65MP0001661_extended_life_span0.72933112
66MP0009780_abnormal_chondrocyte_physiolo0.71258674
67MP0009765_abnormal_xenobiotic_induced0.70943898
68MP0005334_abnormal_fat_pad0.70085268
69MP0005266_abnormal_metabolism0.69582097
70MP0003300_gastrointestinal_ulcer0.67943890
71MP0000477_abnormal_intestine_morphology0.66645169
72MP0005058_abnormal_lysosome_morphology0.66471564
73MP0005220_abnormal_exocrine_pancreas0.64986741
74MP0004147_increased_porphyrin_level0.64657593
75MP0006035_abnormal_mitochondrial_morpho0.63822280
76MP0002132_abnormal_respiratory_system0.63772868
77MP0000230_abnormal_systemic_arterial0.60688481
78MP0005330_cardiomyopathy0.59030807
79MP0001663_abnormal_digestive_system0.58648134
80MP0003724_increased_susceptibility_to0.58361640
81MP0004264_abnormal_extraembryonic_tissu0.57336307
82MP0000249_abnormal_blood_vessel0.57105451
83MP0010352_gastrointestinal_tract_polyps0.54020688
84MP0002928_abnormal_bile_duct0.51723142
85MP0003718_maternal_effect0.51639831
86MP0005448_abnormal_energy_balance0.49848864
87MP0002166_altered_tumor_susceptibility0.49456194
88MP0005381_digestive/alimentary_phenotyp0.47413955
89MP0002796_impaired_skin_barrier0.46847983
90MP0003638_abnormal_response/metabolism_0.45978767
91MP0005164_abnormal_response_to0.45822619
92MP0005023_abnormal_wound_healing0.45581897
93MP0002168_other_aberrant_phenotype0.44381500
94MP0002822_catalepsy0.43616670
95MP0001915_intracranial_hemorrhage0.43447569
96MP0003953_abnormal_hormone_level0.43210454
97MP0008874_decreased_physiological_sensi0.42868267
98MP0005187_abnormal_penis_morphology0.42166999
99MP0009115_abnormal_fat_cell0.41361738
100MP0008873_increased_physiological_sensi0.41146505
101MP0010234_abnormal_vibrissa_follicle0.40805876
102MP0003646_muscle_fatigue0.40414878
103MP0005395_other_phenotype0.40369142
104MP0002009_preneoplasia0.39567612
105MP0008872_abnormal_physiological_respon0.39172890
106MP0002089_abnormal_postnatal_growth/wei0.38608445
107MP0003075_altered_response_to0.38453386
108MP0004185_abnormal_adipocyte_glucose0.38406088
109MP0001873_stomach_inflammation0.38369896
110MP0004272_abnormal_basement_membrane0.38129905
111MP0005464_abnormal_platelet_physiology0.37967312
112MP0005375_adipose_tissue_phenotype0.37670626
113MP0005166_decreased_susceptibility_to0.36803740
114MP0004883_abnormal_blood_vessel0.36254287
115MP0009384_cardiac_valve_regurgitation0.35829513
116MP0005165_increased_susceptibility_to0.34889531
117MP0005167_abnormal_blood-brain_barrier0.34523392
118MP0000538_abnormal_urinary_bladder0.34097963
119MP0003045_fibrosis0.32753336
120MP0008961_abnormal_basal_metabolism0.32174707
121MP0003959_abnormal_lean_body0.32119810
122MP0000467_abnormal_esophagus_morphology0.31251897
123MP0002098_abnormal_vibrissa_morphology0.30949536
124MP0000639_abnormal_adrenal_gland0.30854102
125MP0000462_abnormal_digestive_system0.30821966
126MP0002135_abnormal_kidney_morphology0.30711202
127MP0004782_abnormal_surfactant_physiolog0.30424914
128MP0004036_abnormal_muscle_relaxation0.30411848
129MP0002970_abnormal_white_adipose0.30409559
130MP0002269_muscular_atrophy0.30393804
131MP0002896_abnormal_bone_mineralization0.29645841

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.23564584
2Intrahepatic cholestasis (HP:0001406)6.18150630
3Deep venous thrombosis (HP:0002625)5.76715840
4Xanthomatosis (HP:0000991)5.46229831
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.42633471
6Hypobetalipoproteinemia (HP:0003563)5.06118309
7Hyperglycinuria (HP:0003108)4.75630003
8Prolonged partial thromboplastin time (HP:0003645)4.72827486
9Hyperammonemia (HP:0001987)4.64959622
10Hyperlipoproteinemia (HP:0010980)4.62735814
11Ketosis (HP:0001946)4.56739710
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.50111918
13Abnormality of serine family amino acid metabolism (HP:0010894)4.49563220
14Abnormality of glycine metabolism (HP:0010895)4.49563220
15Abnormality of fatty-acid metabolism (HP:0004359)4.28852664
16Hyperglycinemia (HP:0002154)4.25985096
17Glomerulonephritis (HP:0000099)4.21792342
18Hypoglycemic coma (HP:0001325)4.10243133
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.05875709
20Complement deficiency (HP:0004431)4.05756666
21Hypolipoproteinemia (HP:0010981)3.90749494
22Ketoacidosis (HP:0001993)3.87769258
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.85661048
24Epidermoid cyst (HP:0200040)3.78309034
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.67779692
26Fat malabsorption (HP:0002630)3.67474669
27Joint hemorrhage (HP:0005261)3.62493493
28Gout (HP:0001997)3.60697051
29Hypoalphalipoproteinemia (HP:0003233)3.47305630
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.47153723
31Abnormality of methionine metabolism (HP:0010901)3.46713711
32Dicarboxylic aciduria (HP:0003215)3.34577842
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.34577842
34Abnormality of purine metabolism (HP:0004352)3.31769795
35Abnormality of the common coagulation pathway (HP:0010990)3.29687057
36Conjugated hyperbilirubinemia (HP:0002908)3.19843902
37Flat acetabular roof (HP:0003180)3.15810993
38Metabolic acidosis (HP:0001942)3.15388020
39Generalized aminoaciduria (HP:0002909)3.15367585
40Abnormality of nucleobase metabolism (HP:0010932)3.13736306
41Nephritis (HP:0000123)3.08913883
42Hypercholesterolemia (HP:0003124)3.05555839
43Proximal tubulopathy (HP:0000114)3.04673572
44Delayed CNS myelination (HP:0002188)3.01274613
45Hyperbilirubinemia (HP:0002904)2.97356122
46Abnormality of serum amino acid levels (HP:0003112)2.94070676
47Abnormality of complement system (HP:0005339)2.83297352
48Lethargy (HP:0001254)2.81945950
49Abnormality of the intrinsic pathway (HP:0010989)2.78049992
50Vascular calcification (HP:0004934)2.77673844
51Abnormality of pyrimidine metabolism (HP:0004353)2.77669328
52Gingival bleeding (HP:0000225)2.76262791
53Steatorrhea (HP:0002570)2.74369719
54Alkalosis (HP:0001948)2.73288916
55Menorrhagia (HP:0000132)2.72647114
56Hyperuricemia (HP:0002149)2.70133166
57Increased purine levels (HP:0004368)2.70133166
58Hepatocellular carcinoma (HP:0001402)2.61368293
59Osteomalacia (HP:0002749)2.59141682
60Poikilocytosis (HP:0004447)2.57950082
61Malnutrition (HP:0004395)2.55888741
62Cerebral edema (HP:0002181)2.51838254
63Abnormality of urine glucose concentration (HP:0011016)2.50667365
64Glycosuria (HP:0003076)2.50667365
65Abnormal tarsal ossification (HP:0008369)2.48700904
66Vomiting (HP:0002013)2.46367435
67Cardiovascular calcification (HP:0011915)2.45562562
68Ileus (HP:0002595)2.43859783
69Abnormality of proline metabolism (HP:0010907)2.39600460
70Hydroxyprolinuria (HP:0003080)2.39600460
71Sensorimotor neuropathy (HP:0007141)2.36466677
72Hypophosphatemic rickets (HP:0004912)2.35694487
73Myocardial infarction (HP:0001658)2.33365753
74Abnormality of renin-angiotensin system (HP:0000847)2.31323056
75Skin nodule (HP:0200036)2.30993420
76Spastic diplegia (HP:0001264)2.27927112
77Irritability (HP:0000737)2.25846778
78Decreased circulating renin level (HP:0003351)2.24213456
79Purpura (HP:0000979)2.23017652
80Hyperactive renin-angiotensin system (HP:0000841)2.21784736
81Acanthocytosis (HP:0001927)2.21335844
82Hypoglycemic seizures (HP:0002173)2.20863635
83Hypokalemic alkalosis (HP:0001949)2.20558675
84Hyperphosphaturia (HP:0003109)2.19876606
85Rickets (HP:0002748)2.16538840
86Renal cortical cysts (HP:0000803)2.16174306
87Late onset (HP:0003584)2.15107632
88Abnormal gallbladder morphology (HP:0012437)2.14561566
89Abnormality of carpal bone ossification (HP:0006257)2.14103455
90Neonatal onset (HP:0003623)2.13608920
91Widely patent fontanelles and sutures (HP:0004492)2.10812502
92Cholelithiasis (HP:0001081)2.10154425
93Potter facies (HP:0002009)2.09468539
94Facial shape deformation (HP:0011334)2.09468539
95Spontaneous abortion (HP:0005268)2.09139784
96Pancreatitis (HP:0001733)2.08717485
97Recurrent gram-negative bacterial infections (HP:0005420)2.07684213
98Pigmentary retinal degeneration (HP:0001146)2.07346550
99Abdominal distention (HP:0003270)2.07059733
100Increased circulating renin level (HP:0000848)2.05838683
101Abnormal gallbladder physiology (HP:0012438)2.05337934
102Cholecystitis (HP:0001082)2.05337934
103Enlarged kidneys (HP:0000105)2.04954635
104Systemic lupus erythematosus (HP:0002725)2.03293015
105Metabolic alkalosis (HP:0200114)2.03284628
106Esophageal varix (HP:0002040)2.02558890
107Mitral stenosis (HP:0001718)2.01744408
108Myoglobinuria (HP:0002913)2.00929688
109Abnormal urine phosphate concentration (HP:0012599)1.98225213
110Abnormal enzyme/coenzyme activity (HP:0012379)1.97672638
111Abnormality of vitamin metabolism (HP:0100508)1.97656218
112Hypochromic microcytic anemia (HP:0004840)1.97344878
113Nausea (HP:0002018)1.95840573
114Abnormal cartilage morphology (HP:0002763)1.93739290
115Hypophosphatemia (HP:0002148)1.92096207
116Renal tubular acidosis (HP:0001947)1.91357903
117Hyperinsulinemic hypoglycemia (HP:0000825)1.89127494
118Hypokalemia (HP:0002900)1.88548277
119Focal segmental glomerulosclerosis (HP:0000097)1.86654154
120Hepatic necrosis (HP:0002605)1.86240377
121Arthropathy (HP:0003040)1.84173635
122Cerebral palsy (HP:0100021)1.83493546
123Nephrolithiasis (HP:0000787)1.83392731
124Brushfield spots (HP:0001088)1.81560105
125Thrombophlebitis (HP:0004418)1.80033474
126Abnormality of chloride homeostasis (HP:0011422)1.77840642
127Elevated hepatic transaminases (HP:0002910)1.77475828
128Fair hair (HP:0002286)1.77363711
129Increased mean platelet volume (HP:0011877)1.77359871
130Hemorrhage of the eye (HP:0011885)1.77335320
131Abnormality of potassium homeostasis (HP:0011042)1.77183042
132Abnormality of the gallbladder (HP:0005264)1.77012696
133Abnormal hand bone ossification (HP:0010660)1.75304807
134Hyperaldosteronism (HP:0000859)1.73793192
135Glomerulosclerosis (HP:0000096)1.71071409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.27066345
2ACVR1B4.68027408
3FGFR43.35400499
4SIK13.18626422
5WNK43.05256162
6ERN12.99920630
7AKT32.90701899
8OXSR12.65172311
9EPHA22.52768652
10MST1R2.47247317
11INSRR2.37343087
12WNK32.10341911
13PKN22.03031335
14EPHB12.02352023
15STK391.99564690
16ERBB41.81039414
17TAOK31.74828967
18TRIB31.74331003
19MAP3K71.68555796
20FRK1.66204023
21PDK41.63677154
22PDK31.63677154
23PINK11.35829488
24MAPK111.35648032
25MAPKAPK31.32651572
26FLT31.32506488
27MAP2K41.31213243
28FGFR21.31141340
29PTK61.25886047
30MAP2K31.24926946
31PRKAA21.24116314
32MAP3K31.23693548
33SGK4941.16940879
34SGK2231.16940879
35FER1.15779285
36TIE11.15737641
37MYLK1.15303239
38GRK61.15212807
39NEK91.14101187
40LMTK21.13272122
41TYK21.13043584
42EIF2AK11.12720493
43PRKG21.12178429
44MET1.11446971
45MAP3K21.10960004
46EEF2K1.09197352
47SGK31.08733528
48STK38L1.08254849
49CDK121.08177289
50PDK21.05196810
51LATS11.02159168
52JAK21.00495947
53PIK3CA0.96853228
54PIK3CG0.96090347
55NLK0.95668208
56KDR0.92337261
57PDGFRA0.89010517
58SGK20.87214168
59TGFBR20.82880424
60RIPK10.82403307
61CDC42BPA0.81040041
62DDR20.80303343
63ABL20.80177750
64JAK10.79930918
65CAMK1D0.79818134
66PAK30.77971203
67MAPK150.76810063
68PDPK10.75994436
69GSK3A0.74207805
70PRKAA10.72733526
71MAP3K120.72014690
72TTN0.71976535
73BRSK20.69152242
74MAPK120.68138210
75MAP2K60.67554444
76MAPK40.66397463
77MAP3K100.66274667
78PRKCH0.64274310
79PRKCQ0.64074038
80TRPM70.62941127
81ICK0.62331828
82LRRK20.61239558
83YES10.60527008
84IGF1R0.59733549
85MAP2K10.59668271
86PRKACG0.59353034
87WNK10.57999427
88TBK10.57580275
89MAP2K20.57365490
90PDK10.56848258
91MAP3K140.56548687
92EPHA30.56127975
93CSK0.56068073
94ITK0.55781712
95FGFR30.55406354
96CAMK2G0.54621401
97DAPK20.53623681
98PRKCZ0.52986683
99ERBB20.52230912
100GRK10.51708035
101CSNK1G10.51229362
102KSR20.48049846
103RET0.47580251
104PRKD10.46734241
105PTK20.46218445
106MST40.45963201
107MAP3K10.45882307
108FGFR10.44855060
109PHKG10.44770015
110PHKG20.44770015
111MAPK70.44533768
112BCR0.44352395
113CDK60.44053356
114CAMKK20.43824421
115IKBKE0.42951992
116MELK0.41996243
117NEK60.41668101
118CAMK1G0.40464231
119STK240.40314025
120NEK10.39947400
121CSF1R0.39291045
122DYRK1B0.38887778
123STK380.38566873
124STK30.37912113
125SGK10.37640561
126TESK20.36893613
127PKN10.36844056
128PDGFRB0.36600463
129MAP4K10.36168169
130IRAK30.36107639
131STK100.35904123
132MTOR0.35674762
133ZAP700.35144940
134RPS6KB10.34992808
135SRC0.34599354
136PRKCA0.33374937
137PRKG10.31362981
138BMPR1B0.27720995

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.68886915
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47831800
3Nitrogen metabolism_Homo sapiens_hsa009103.03403941
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90805031
5Fatty acid degradation_Homo sapiens_hsa000712.83006176
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.73560137
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65492838
8Tryptophan metabolism_Homo sapiens_hsa003802.61191331
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58378308
10Butanoate metabolism_Homo sapiens_hsa006502.55060935
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.52944323
12Arginine biosynthesis_Homo sapiens_hsa002202.51523623
13Propanoate metabolism_Homo sapiens_hsa006402.46208775
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.29596570
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26140303
16Peroxisome_Homo sapiens_hsa041462.15849848
17Fatty acid metabolism_Homo sapiens_hsa012122.09045842
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05339253
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.03108573
20Complement and coagulation cascades_Homo sapiens_hsa046102.00071808
21Chemical carcinogenesis_Homo sapiens_hsa052041.99496666
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96431854
23PPAR signaling pathway_Homo sapiens_hsa033201.91867297
24beta-Alanine metabolism_Homo sapiens_hsa004101.85035602
25Histidine metabolism_Homo sapiens_hsa003401.81965095
26Sulfur metabolism_Homo sapiens_hsa009201.78082043
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.77579081
28Caffeine metabolism_Homo sapiens_hsa002321.69230754
29Pyruvate metabolism_Homo sapiens_hsa006201.67762689
30Retinol metabolism_Homo sapiens_hsa008301.64002417
31Bile secretion_Homo sapiens_hsa049761.54770557
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.53827712
33Fatty acid elongation_Homo sapiens_hsa000621.53550462
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48912376
35Starch and sucrose metabolism_Homo sapiens_hsa005001.46131939
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43392914
37Phenylalanine metabolism_Homo sapiens_hsa003601.38581012
38Carbon metabolism_Homo sapiens_hsa012001.38119556
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33636992
40Selenocompound metabolism_Homo sapiens_hsa004501.32256027
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.29506798
42Tyrosine metabolism_Homo sapiens_hsa003501.24789791
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24423510
44Staphylococcus aureus infection_Homo sapiens_hsa051501.17482411
45ABC transporters_Homo sapiens_hsa020101.14576714
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14144267
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.13343096
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12173088
49Biosynthesis of amino acids_Homo sapiens_hsa012301.10644538
50Fat digestion and absorption_Homo sapiens_hsa049751.08166520
51Folate biosynthesis_Homo sapiens_hsa007901.07629509
52Glutathione metabolism_Homo sapiens_hsa004801.05973446
53Steroid biosynthesis_Homo sapiens_hsa001001.05279939
54Vitamin digestion and absorption_Homo sapiens_hsa049771.03572510
55Arginine and proline metabolism_Homo sapiens_hsa003300.98396322
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97464720
57Sulfur relay system_Homo sapiens_hsa041220.93152570
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91139035
59Lysine degradation_Homo sapiens_hsa003100.90241074
60Glycerolipid metabolism_Homo sapiens_hsa005610.82699236
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81375933
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.76741337
63Vitamin B6 metabolism_Homo sapiens_hsa007500.67202721
64Pentose phosphate pathway_Homo sapiens_hsa000300.58654064
65Fatty acid biosynthesis_Homo sapiens_hsa000610.55618591
66Metabolic pathways_Homo sapiens_hsa011000.48759394
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45926039
68Galactose metabolism_Homo sapiens_hsa000520.35178400
69Fructose and mannose metabolism_Homo sapiens_hsa000510.35105459
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35035046
71Sphingolipid metabolism_Homo sapiens_hsa006000.30730148
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.30618329
73One carbon pool by folate_Homo sapiens_hsa006700.29522808
74Insulin resistance_Homo sapiens_hsa049310.29434159
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28932734
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26637500
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15133704
78Ether lipid metabolism_Homo sapiens_hsa005650.14658803
79Linoleic acid metabolism_Homo sapiens_hsa005910.13859685
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.13517596
81Mineral absorption_Homo sapiens_hsa049780.12701105
82Prion diseases_Homo sapiens_hsa050200.11365023
83Glucagon signaling pathway_Homo sapiens_hsa049220.10551921
84Pertussis_Homo sapiens_hsa051330.09809358
85Pancreatic secretion_Homo sapiens_hsa049720.08902311
86AMPK signaling pathway_Homo sapiens_hsa041520.06570141
87Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2013972
88Lysosome_Homo sapiens_hsa04142-0.1896676
89Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1790869
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1667011
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1659668
92Alzheimers disease_Homo sapiens_hsa05010-0.1516059
93Hepatitis C_Homo sapiens_hsa05160-0.1410759
94Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1267602
95Parkinsons disease_Homo sapiens_hsa05012-0.1258957
96Circadian rhythm_Homo sapiens_hsa04710-0.0885856
97N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0881792
98Other glycan degradation_Homo sapiens_hsa00511-0.0838957
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0770416
100Insulin signaling pathway_Homo sapiens_hsa04910-0.0681775
101Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0671225
102Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0664686
103Oxidative phosphorylation_Homo sapiens_hsa00190-0.0651097
104Serotonergic synapse_Homo sapiens_hsa04726-0.0491624
105Protein digestion and absorption_Homo sapiens_hsa04974-0.0371675
106Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0324711
107Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0092193
108Renin-angiotensin system_Homo sapiens_hsa04614-0.0039072

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