ENTPD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.73402856
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.81090889
3locomotory exploration behavior (GO:0035641)4.71483510
4piRNA metabolic process (GO:0034587)4.64454219
5Golgi transport vesicle coating (GO:0048200)4.61056613
6COPI coating of Golgi vesicle (GO:0048205)4.61056613
7proline transport (GO:0015824)4.59993978
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.56642858
9synaptic vesicle maturation (GO:0016188)4.55654477
10vocalization behavior (GO:0071625)4.52062143
11regulation of glutamate receptor signaling pathway (GO:1900449)4.39560246
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.27352489
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17873760
14protein retention in ER lumen (GO:0006621)4.17298650
15synaptic vesicle exocytosis (GO:0016079)4.14809175
16glutamate secretion (GO:0014047)4.13930350
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.10278659
18protein localization to synapse (GO:0035418)4.05355100
19cilium or flagellum-dependent cell motility (GO:0001539)3.98008215
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.97836141
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.92135523
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.89299914
23synaptic transmission, glutamatergic (GO:0035249)3.85847396
24neurotransmitter-gated ion channel clustering (GO:0072578)3.83745515
25positive regulation of synapse maturation (GO:0090129)3.79563025
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.74115796
27exploration behavior (GO:0035640)3.70439857
28long-term memory (GO:0007616)3.67580055
29regulation of synaptic vesicle transport (GO:1902803)3.66509870
30cell communication by electrical coupling (GO:0010644)3.66296400
31regulation of synaptic vesicle exocytosis (GO:2000300)3.65896368
32regulation of cholesterol homeostasis (GO:2000188)3.65014352
33positive regulation of synaptic transmission, GABAergic (GO:0032230)3.63037865
34regulation of neuronal synaptic plasticity (GO:0048168)3.62110534
35neurotransmitter secretion (GO:0007269)3.61227505
36glutamate receptor signaling pathway (GO:0007215)3.60387717
37alanine transport (GO:0032328)3.55903227
38response to auditory stimulus (GO:0010996)3.54420759
39response to pheromone (GO:0019236)3.51538502
40neuron cell-cell adhesion (GO:0007158)3.49082003
41regulation of cholesterol biosynthetic process (GO:0045540)3.47117361
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.45248726
43regulation of synapse structural plasticity (GO:0051823)3.40966560
44cellular potassium ion homeostasis (GO:0030007)3.38530122
45DNA methylation involved in gamete generation (GO:0043046)3.36703646
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.35884795
47G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.35618682
48protein localization to endosome (GO:0036010)3.35289745
49neuron-neuron synaptic transmission (GO:0007270)3.33500764
50calcium ion-dependent exocytosis (GO:0017156)3.30432178
51behavioral defense response (GO:0002209)3.26025978
52behavioral fear response (GO:0001662)3.26025978
53gamma-aminobutyric acid transport (GO:0015812)3.25925873
54layer formation in cerebral cortex (GO:0021819)3.22785572
55acrosome reaction (GO:0007340)3.22703473
56sodium ion export (GO:0071436)3.21339329
57cell-cell junction maintenance (GO:0045217)3.16454249
58synaptic vesicle endocytosis (GO:0048488)3.16430220
59male meiosis (GO:0007140)3.16168700
60activation of protein kinase A activity (GO:0034199)3.15770749
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14010798
62regulation of synapse maturation (GO:0090128)3.12400580
63regulation of ARF protein signal transduction (GO:0032012)3.11433501
64proline biosynthetic process (GO:0006561)3.10955784
65semaphorin-plexin signaling pathway (GO:0071526)3.09967185
66NADH metabolic process (GO:0006734)3.07446964
67glucose 6-phosphate metabolic process (GO:0051156)3.06896244
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02008424
69binding of sperm to zona pellucida (GO:0007339)3.01775750
70actin filament depolymerization (GO:0030042)3.01774803
71peptidyl-arginine omega-N-methylation (GO:0035247)3.00920888
72peptidyl-arginine N-methylation (GO:0035246)3.00869015
73peptidyl-arginine methylation (GO:0018216)3.00869015
74motile cilium assembly (GO:0044458)3.00518660
75auditory behavior (GO:0031223)2.99714854
76negative regulation of cell size (GO:0045792)2.99478220
77proline metabolic process (GO:0006560)2.98023469
78negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95489374
79sperm motility (GO:0030317)2.95169734
80fear response (GO:0042596)2.94647126
81desmosome organization (GO:0002934)2.94096757
82regulation of cholesterol metabolic process (GO:0090181)2.91569396
83sperm-egg recognition (GO:0035036)2.90093083
84amino acid import (GO:0043090)2.89039276
85activation of Rac GTPase activity (GO:0032863)2.88263657
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.87806562
87positive regulation of membrane potential (GO:0045838)2.85922715
88protein-lipid complex assembly (GO:0065005)2.83434144
89regulation of synaptic plasticity (GO:0048167)2.83311873
90positive regulation of neurotransmitter secretion (GO:0001956)2.83035512
91histone arginine methylation (GO:0034969)2.82114891
92neurotransmitter transport (GO:0006836)2.79217146
93regulation of extracellular matrix disassembly (GO:0010715)2.79208529
94positive regulation of dendritic spine morphogenesis (GO:0061003)2.78886894
95membrane depolarization during action potential (GO:0086010)2.78408967
96barbed-end actin filament capping (GO:0051016)2.77837253
97activation of MAPKKK activity (GO:0000185)2.76659806
98negative regulation of microtubule polymerization (GO:0031115)2.75090360
99regulation of early endosome to late endosome transport (GO:2000641)2.75056601
100regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.75046314
101histone H2A acetylation (GO:0043968)2.73847050
102plasma lipoprotein particle assembly (GO:0034377)2.73492239
103basement membrane organization (GO:0071711)2.72229875
104regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71961849
105adherens junction assembly (GO:0034333)2.70870790
106fusion of sperm to egg plasma membrane (GO:0007342)2.70700100
107postsynaptic membrane organization (GO:0001941)2.70091065
108synaptonemal complex organization (GO:0070193)2.69370122
109response to histamine (GO:0034776)2.69342707
110G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.68921594
111regulation of synaptic transmission, GABAergic (GO:0032228)2.68530368
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.67338404
113very-low-density lipoprotein particle assembly (GO:0034379)2.67100623
114plasma membrane fusion (GO:0045026)2.65388526
115epithelial cell-cell adhesion (GO:0090136)2.65132311
116transmission of nerve impulse (GO:0019226)2.64990299
117negative regulation of protein oligomerization (GO:0032460)2.64853210
118synaptonemal complex assembly (GO:0007130)2.64151199
119learning (GO:0007612)2.63852921
120cell junction maintenance (GO:0034331)2.62617315
121cell-cell recognition (GO:0009988)2.60742072
122mannose metabolic process (GO:0006013)2.58935488
123regulation of vesicle fusion (GO:0031338)2.58549685
124regulation of neurotransmitter levels (GO:0001505)2.58229024
125regulation of cholesterol esterification (GO:0010872)2.57927334
126regulation of postsynaptic membrane potential (GO:0060078)2.57208339
127dendritic spine organization (GO:0097061)2.56516634
128dendritic spine morphogenesis (GO:0060997)2.55038569
129positive regulation of neurotransmitter transport (GO:0051590)2.54666638
130cerebellar granule cell differentiation (GO:0021707)2.54298635
131activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53792300
132regulation of neurotransmitter secretion (GO:0046928)2.52503386
133regulation of ARF GTPase activity (GO:0032312)2.52031910
134receptor recycling (GO:0001881)2.52030023
135phosphatidylglycerol biosynthetic process (GO:0006655)2.51425899
136positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51343493
137cerebellar Purkinje cell differentiation (GO:0021702)2.51009578
138negative regulation of dendrite development (GO:2000171)2.50535572
139amyloid precursor protein catabolic process (GO:0042987)2.50145691
140adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.49842802
141protein targeting to plasma membrane (GO:0072661)2.49573322
142neuronal ion channel clustering (GO:0045161)2.49513725
143cell-substrate adherens junction assembly (GO:0007045)2.49131122
144focal adhesion assembly (GO:0048041)2.49131122
145mating behavior (GO:0007617)2.48576860
146adhesion of symbiont to host (GO:0044406)2.48416712
147gamma-aminobutyric acid signaling pathway (GO:0007214)2.48366537
148positive regulation of synaptic transmission (GO:0050806)2.48128803
149regulation of mammary gland epithelial cell proliferation (GO:0033599)2.48026728
1504-hydroxyproline metabolic process (GO:0019471)2.47979260
151cell volume homeostasis (GO:0006884)2.47316570
152peptidyl-tyrosine autophosphorylation (GO:0038083)2.47206826
153regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.46907392
154cellular sodium ion homeostasis (GO:0006883)2.45288667
155regulation of glucose import in response to insulin stimulus (GO:2001273)2.43258288
156glutamine family amino acid biosynthetic process (GO:0009084)2.42035331
157endothelial cell chemotaxis (GO:0035767)2.41571192
158protein carboxylation (GO:0018214)2.39484708
159peptidyl-glutamic acid carboxylation (GO:0017187)2.39484708
160negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.39285821
161cellular response to prostaglandin stimulus (GO:0071379)2.37112538
162positive regulation of nuclease activity (GO:0032075)2.35855753
163myelin maintenance (GO:0043217)2.35597638
164dopamine receptor signaling pathway (GO:0007212)2.35212355
165cellular component maintenance (GO:0043954)2.33364441
166receptor catabolic process (GO:0032801)2.31948126
167low-density lipoprotein particle clearance (GO:0034383)2.31366857
168stress fiber assembly (GO:0043149)2.31089464
169neuromuscular process controlling balance (GO:0050885)2.28296660
170cell-substrate junction assembly (GO:0007044)2.28182499
171signal complex assembly (GO:0007172)2.27922920
172L-serine transport (GO:0015825)2.24946210
173cell communication involved in cardiac conduction (GO:0086065)2.24773945
174amyloid precursor protein metabolic process (GO:0042982)2.24727029
175maternal placenta development (GO:0001893)2.24294452
176fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.23772339
177cellular copper ion homeostasis (GO:0006878)2.22626893
178negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.21709693
179cerebellar Purkinje cell layer development (GO:0021680)2.20997937
180vesicle coating (GO:0006901)2.20109952
181positive regulation of pseudopodium assembly (GO:0031274)2.19531892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.02248454
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.66561718
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.17947802
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.03167115
5REST_21632747_ChIP-Seq_MESCs_Mouse3.02483539
6LXR_22292898_ChIP-Seq_THP-1_Human3.01827654
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.92060792
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70414968
9GBX2_23144817_ChIP-Seq_PC3_Human2.64547506
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.61804663
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.49628335
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.45791768
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.40073926
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39921945
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38071794
16RACK7_27058665_Chip-Seq_MCF-7_Human2.36858243
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36147726
18ZNF263_19887448_ChIP-Seq_K562_Human2.35642989
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.33141653
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.28758431
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24543103
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20715626
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16574455
24DROSHA_22980978_ChIP-Seq_HELA_Human2.14955501
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.09486573
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.08057518
27KDM2B_26808549_Chip-Seq_K562_Human2.04735325
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93164200
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92364456
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87486572
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.87467152
32CLOCK_20551151_ChIP-Seq_293T_Human1.78658177
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76829714
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76806913
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.74483445
36VDR_21846776_ChIP-Seq_THP-1_Human1.73199985
37KDM2B_26808549_Chip-Seq_DND41_Human1.72729239
38TCF7_22412390_ChIP-Seq_EML_Mouse1.69445039
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69094432
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68742634
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67460262
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66016609
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63564986
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.63359785
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61492165
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60955526
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.60572101
48SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.57777166
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53656996
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53491696
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.52584885
52* CREB1_26743006_Chip-Seq_LNCaP_Human1.50437021
53E2F7_22180533_ChIP-Seq_HELA_Human1.49380921
54* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47602653
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47266815
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47013731
57ZNF274_21170338_ChIP-Seq_K562_Hela1.46116430
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.45839657
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.45816925
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43980021
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.43592776
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43121298
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40756800
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.40649302
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.40445150
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39723327
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.38316647
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36984462
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36730662
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35674620
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35002091
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34815302
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32231134
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31884881
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.31416865
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30962097
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.30076443
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28490212
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27559647
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27518887
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24173886
82ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23833580
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22378553
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22378553
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21950316
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21893693
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19554708
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18961055
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18955968
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18397330
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18364475
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17923616
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.17498657
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17300039
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16798447
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.16662275
97ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15859183
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14832366
99SMC4_20622854_ChIP-Seq_HELA_Human1.14599922
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13877078
101CIITA_25753668_ChIP-Seq_RAJI_Human1.13616782
102WDR5_24793694_ChIP-Seq_LNCAP_Human1.13134119
103* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12181466
104SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.11919384
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11823028
106TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10862794
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10550892
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10488585
109ATF3_27146783_Chip-Seq_COLON_Human1.09987240
110* TP53_22127205_ChIP-Seq_IMR90_Human1.09709415
111OCT4_19829295_ChIP-Seq_ESCs_Human1.09544571
112* BCOR_27268052_Chip-Seq_Bcells_Human1.08011105
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07722161
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07712097
115JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07098424
116* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06709577
117RNF2_27304074_Chip-Seq_NSC_Mouse1.06481450
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06442197
119RARA_24833708_ChIP-Seq_LIVER_Mouse1.05463678
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04723509
121TP63_22573176_ChIP-Seq_HFKS_Human1.04188762
122TET1_21451524_ChIP-Seq_MESCs_Mouse1.03692733
123ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03050257
124* PHF8_20622854_ChIP-Seq_HELA_Human1.02410620
125MYC_22102868_ChIP-Seq_BL_Human1.01979017
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.01816956
127TET1_21490601_ChIP-Seq_MESCs_Mouse1.00893405
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00545377
129RARB_24833708_ChIP-Seq_LIVER_Mouse1.00011879
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99522754
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97914214
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97872296
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97827471
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97731166
135* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97157327
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97095255
137TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96524204
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96381401
139KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96354290
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.95722364
141* BCL6_27268052_Chip-Seq_Bcells_Human0.95679689
142MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95190322
143ETS1_21867929_ChIP-Seq_TH2_Mouse0.95050819
144NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94073096
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93336059
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93336059
147* P68_20966046_ChIP-Seq_HELA_Human0.92435300
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.88272314
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88017366
150* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87292500
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86664182
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.86491028
153JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85728881
154SMAD4_21799915_ChIP-Seq_A2780_Human0.85622307
155AR_25329375_ChIP-Seq_VCAP_Human0.82506249
156* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80967892
157CTCF_27219007_Chip-Seq_Bcells_Human0.80301424
158* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80158576
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80122398
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79873063
161E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79137608
162STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79046737
163SOX2_21211035_ChIP-Seq_LN229_Human0.78490243
164* AR_19668381_ChIP-Seq_PC3_Human0.78319748
165FLI1_27457419_Chip-Seq_LIVER_Mouse0.77093699
166SMAD4_21741376_ChIP-Seq_ESCs_Human0.76396551
167SMAD3_21741376_ChIP-Seq_ESCs_Human0.76117669
168FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75811147
169SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75623858
170* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74992703
171* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74890567
172CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74366727
173CBX2_27304074_Chip-Seq_ESCs_Mouse0.74349558
174KLF4_19829295_ChIP-Seq_ESCs_Human0.74118341
175SOX2_21211035_ChIP-Seq_LN229_Gbm0.72983181
176MYC_19079543_ChIP-ChIP_MESCs_Mouse0.72852207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02629667
2MP0003635_abnormal_synaptic_transmissio3.56255594
3MP0005058_abnormal_lysosome_morphology3.49436511
4MP0008877_abnormal_DNA_methylation3.44731990
5MP0003880_abnormal_central_pattern3.27362217
6MP0003705_abnormal_hypodermis_morpholog3.20589218
7MP0005410_abnormal_fertilization3.12109785
8MP0009840_abnormal_foam_cell3.07942508
9MP0010234_abnormal_vibrissa_follicle3.00753868
10MP0002063_abnormal_learning/memory/cond2.98764098
11MP0009745_abnormal_behavioral_response2.96211994
12MP0005409_darkened_coat_color2.93058610
13MP0008260_abnormal_autophagy2.74830639
14MP0005360_urolithiasis2.65215037
15MP0002822_catalepsy2.63172415
16MP0005451_abnormal_body_composition2.62344170
17MP0002735_abnormal_chemical_nociception2.61444047
18MP0003172_abnormal_lysosome_physiology2.58087301
19MP0005423_abnormal_somatic_nervous2.51736319
20MP0003787_abnormal_imprinting2.51720247
21MP0001968_abnormal_touch/_nociception2.46821636
22MP0002572_abnormal_emotion/affect_behav2.43759741
23MP0009046_muscle_twitch2.43238149
24MP0002064_seizures2.38670060
25MP0002736_abnormal_nociception_after2.34034196
26MP0004270_analgesia2.15216482
27MP0001849_ear_inflammation2.14944849
28MP0003191_abnormal_cellular_cholesterol2.12480553
29MP0001501_abnormal_sleep_pattern1.95069216
30MP0000604_amyloidosis1.89809229
31MP0001486_abnormal_startle_reflex1.87616889
32MP0001440_abnormal_grooming_behavior1.81313916
33MP0002272_abnormal_nervous_system1.81224503
34MP0003646_muscle_fatigue1.79381625
35MP0002139_abnormal_hepatobiliary_system1.73926992
36MP0002734_abnormal_mechanical_nocicepti1.72528572
37MP0003698_abnormal_male_reproductive1.72121828
38MP0002557_abnormal_social/conspecific_i1.70935839
39MP0005645_abnormal_hypothalamus_physiol1.70557204
40MP0003566_abnormal_cell_adhesion1.67771506
41MP0001529_abnormal_vocalization1.67282628
42MP0002733_abnormal_thermal_nociception1.62744219
43MP0001970_abnormal_pain_threshold1.62544261
44MP0005257_abnormal_intraocular_pressure1.59908654
45MP0005646_abnormal_pituitary_gland1.59185793
46MP0004858_abnormal_nervous_system1.56925182
47MP0003123_paternal_imprinting1.56251704
48MP0004811_abnormal_neuron_physiology1.55660421
49MP0000678_abnormal_parathyroid_gland1.54658571
50MP0004264_abnormal_extraembryonic_tissu1.53457398
51MP0002067_abnormal_sensory_capabilities1.50705457
52MP0001929_abnormal_gametogenesis1.49720883
53MP0005623_abnormal_meninges_morphology1.49610727
54MP0006292_abnormal_olfactory_placode1.48899196
55MP0000566_synostosis1.46285243
56MP0005365_abnormal_bile_salt1.43887043
57MP0002184_abnormal_innervation1.42545016
58MP0003879_abnormal_hair_cell1.40756693
59MP0006276_abnormal_autonomic_nervous1.40554772
60MP0003634_abnormal_glial_cell1.37992134
61MP0001984_abnormal_olfaction1.37808319
62MP0005386_behavior/neurological_phenoty1.37559075
63MP0004924_abnormal_behavior1.37559075
64MP0005076_abnormal_cell_differentiation1.36903362
65MP0008569_lethality_at_weaning1.36645488
66MP0002877_abnormal_melanocyte_morpholog1.35038161
67MP0000920_abnormal_myelination1.34726875
68MP0003075_altered_response_to1.34432476
69MP0010094_abnormal_chromosome_stability1.33486789
70MP0008438_abnormal_cutaneous_collagen1.29997374
71MP0003121_genomic_imprinting1.29788316
72MP0002653_abnormal_ependyma_morphology1.29659022
73MP0000003_abnormal_adipose_tissue1.28769883
74MP0002909_abnormal_adrenal_gland1.27144407
75MP0004233_abnormal_muscle_weight1.26697330
76MP0003329_amyloid_beta_deposits1.26293484
77MP0003690_abnormal_glial_cell1.26291956
78MP0003453_abnormal_keratinocyte_physiol1.26231547
79MP0003111_abnormal_nucleus_morphology1.25896577
80MP0003183_abnormal_peptide_metabolism1.23354792
81MP0001666_abnormal_nutrient_absorption1.18962685
82MP0000778_abnormal_nervous_system1.18948727
83MP0010329_abnormal_lipoprotein_level1.18395163
84MP0003693_abnormal_embryo_hatching1.16305072
85MP0002249_abnormal_larynx_morphology1.15996068
86MP0001348_abnormal_lacrimal_gland1.15971122
87MP0000013_abnormal_adipose_tissue1.15008919
88MP0000955_abnormal_spinal_cord1.14970798
89MP0002210_abnormal_sex_determination1.13868446
90MP0003122_maternal_imprinting1.13176631
91MP0005666_abnormal_adipose_tissue1.12965055
92MP0003136_yellow_coat_color1.12024467
93MP0000569_abnormal_digit_pigmentation1.11880935
94MP0008961_abnormal_basal_metabolism1.10997995
95MP0008058_abnormal_DNA_repair1.09650934
96MP0000858_altered_metastatic_potential1.09156721
97MP0000462_abnormal_digestive_system1.09011725
98MP0008872_abnormal_physiological_respon1.08463542
99MP0001502_abnormal_circadian_rhythm1.08169880
100MP0002066_abnormal_motor_capabilities/c1.07843988
101MP0004510_myositis1.06183105
102MP0003091_abnormal_cell_migration1.06180016
103MP0002152_abnormal_brain_morphology1.04637573
104MP0005375_adipose_tissue_phenotype1.04455680
105MP0002896_abnormal_bone_mineralization1.04011890
106MP0005174_abnormal_tail_pigmentation1.03620506
107MP0002796_impaired_skin_barrier0.99576756
108MP0002882_abnormal_neuron_morphology0.99139590
109MP0002102_abnormal_ear_morphology0.98283522
110MP0004272_abnormal_basement_membrane0.97734000
111MP0000747_muscle_weakness0.95850821
112MP0002161_abnormal_fertility/fecundity0.95740742
113MP0001145_abnormal_male_reproductive0.95042457
114MP0004185_abnormal_adipocyte_glucose0.94424735
115MP0008874_decreased_physiological_sensi0.93576696
116MP0008004_abnormal_stomach_pH0.92150490
117MP0000751_myopathy0.90766552
118MP0009780_abnormal_chondrocyte_physiolo0.90710075
119MP0005171_absent_coat_pigmentation0.87454555
120MP0004947_skin_inflammation0.85696263
121MP0004142_abnormal_muscle_tone0.85092666
122MP0000467_abnormal_esophagus_morphology0.85069699
123MP0000681_abnormal_thyroid_gland0.84246255
124MP0002089_abnormal_postnatal_growth/wei0.84196060
125MP0005330_cardiomyopathy0.83844198
126MP0000653_abnormal_sex_gland0.83265559
127MP0002876_abnormal_thyroid_physiology0.82979233
128MP0009384_cardiac_valve_regurgitation0.82379229
129MP0004885_abnormal_endolymph0.80688295
130MP0005166_decreased_susceptibility_to0.80381245
131MP0003633_abnormal_nervous_system0.80376523
132MP0002069_abnormal_eating/drinking_beha0.79792247
133MP0002118_abnormal_lipid_homeostasis0.78689634
134MP0005501_abnormal_skin_physiology0.78004451
135MP0001765_abnormal_ion_homeostasis0.77739169
136MP0002160_abnormal_reproductive_system0.77209802
137MP0001188_hyperpigmentation0.76011753
138MP0005394_taste/olfaction_phenotype0.75688600
139MP0005499_abnormal_olfactory_system0.75688600
140MP0001905_abnormal_dopamine_level0.75102240
141MP0003631_nervous_system_phenotype0.74963017
142MP0001664_abnormal_digestion0.74785693
143MP0001963_abnormal_hearing_physiology0.74377651
144MP0005670_abnormal_white_adipose0.73733464
145MP0008057_abnormal_DNA_replication0.72501786
146MP0003861_abnormal_nervous_system0.72442810
147MP0005023_abnormal_wound_healing0.71885816
148MP0004215_abnormal_myocardial_fiber0.71685901
149MP0003077_abnormal_cell_cycle0.71397075
150MP0004019_abnormal_vitamin_homeostasis0.69456174
151MP0004782_abnormal_surfactant_physiolog0.69218781
152MP0003632_abnormal_nervous_system0.68538800
153MP0010386_abnormal_urinary_bladder0.68383576
154MP0003763_abnormal_thymus_physiology0.67919394
155MP0002098_abnormal_vibrissa_morphology0.67853442
156MP0003137_abnormal_impulse_conducting0.66613876
157MP0000631_abnormal_neuroendocrine_gland0.66052764
158MP0005165_increased_susceptibility_to0.65456576
159MP0004130_abnormal_muscle_cell0.65041914
160MP0003115_abnormal_respiratory_system0.64921437
161MP0005584_abnormal_enzyme/coenzyme_acti0.64507383
162MP0000537_abnormal_urethra_morphology0.64480081
163MP0003315_abnormal_perineum_morphology0.63114386
164MP0003283_abnormal_digestive_organ0.62494984
165MP0004133_heterotaxia0.61007611
166MP0005621_abnormal_cell_physiology0.60888397
167MP0001958_emphysema0.59204025
168MP0000015_abnormal_ear_pigmentation0.57661644
169MP0004957_abnormal_blastocyst_morpholog0.57353456

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.34364353
2Myokymia (HP:0002411)4.99374819
3Abnormality of the lower motor neuron (HP:0002366)4.06484835
4Absent/shortened dynein arms (HP:0200106)3.86137938
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.86137938
6Neurofibrillary tangles (HP:0002185)3.71916516
7Epileptic encephalopathy (HP:0200134)3.68824868
8Febrile seizures (HP:0002373)3.62998152
9Deep venous thrombosis (HP:0002625)3.58875861
10Focal seizures (HP:0007359)3.53561932
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.46384147
12Distal upper limb amyotrophy (HP:0007149)3.41662988
13Upper limb amyotrophy (HP:0009129)3.41662988
14Visual hallucinations (HP:0002367)3.35340237
15Cerebral inclusion bodies (HP:0100314)3.34875353
16Amyotrophic lateral sclerosis (HP:0007354)3.28594414
17Progressive cerebellar ataxia (HP:0002073)3.09557978
18Polyphagia (HP:0002591)2.98962692
19Flat acetabular roof (HP:0003180)2.97917292
20Cerebral aneurysm (HP:0004944)2.97207064
21Distal lower limb amyotrophy (HP:0008944)2.92750567
22Hand muscle atrophy (HP:0009130)2.86378707
23Postural instability (HP:0002172)2.82276354
24Progressive inability to walk (HP:0002505)2.79749682
25Atonic seizures (HP:0010819)2.79745199
26Hemorrhage of the eye (HP:0011885)2.77369881
27Impaired vibration sensation in the lower limbs (HP:0002166)2.75818635
28Abnormal eating behavior (HP:0100738)2.70025508
29Neuronal loss in central nervous system (HP:0002529)2.69612082
30Obstructive sleep apnea (HP:0002870)2.66315266
31Generalized tonic-clonic seizures (HP:0002069)2.64372580
32Broad face (HP:0000283)2.60290798
33Protrusio acetabuli (HP:0003179)2.59963158
34Mutism (HP:0002300)2.56655273
35Ankle clonus (HP:0011448)2.56399479
36Abnormal respiratory epithelium morphology (HP:0012253)2.54131626
37Abnormal respiratory motile cilium morphology (HP:0005938)2.54131626
38Abnormality of ocular smooth pursuit (HP:0000617)2.53487328
39Infertility (HP:0000789)2.51993963
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50072964
41Lower limb amyotrophy (HP:0007210)2.49136473
42Abnormality of carpal bone ossification (HP:0006257)2.47708622
43Broad-based gait (HP:0002136)2.47438609
44Poor eye contact (HP:0000817)2.47130727
45Vertebral compression fractures (HP:0002953)2.46780468
46J-shaped sella turcica (HP:0002680)2.46522686
47Gaze-evoked nystagmus (HP:0000640)2.46430109
48Abnormal respiratory motile cilium physiology (HP:0012261)2.41817412
49Hemiplegia (HP:0002301)2.41536263
50Abnormality of the Achilles tendon (HP:0005109)2.40712476
51Achilles tendon contracture (HP:0001771)2.40386826
52Absence seizures (HP:0002121)2.35329509
53Large eyes (HP:0001090)2.34208561
54Axonal loss (HP:0003447)2.33204304
55Inability to walk (HP:0002540)2.33050869
56Thin bony cortex (HP:0002753)2.32704515
57Unsteady gait (HP:0002317)2.32342561
58Rhinitis (HP:0012384)2.32086811
59Impaired smooth pursuit (HP:0007772)2.31436717
60Stridor (HP:0010307)2.30769497
61Difficulty climbing stairs (HP:0003551)2.30523839
62Akinesia (HP:0002304)2.28971188
63Dysostosis multiplex (HP:0000943)2.28968177
64Distal lower limb muscle weakness (HP:0009053)2.27617956
65Diplopia (HP:0000651)2.27015958
66Abnormality of binocular vision (HP:0011514)2.27015958
67Hemiparesis (HP:0001269)2.25617201
68Bradykinesia (HP:0002067)2.24669861
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24513483
70Abnormality of alanine metabolism (HP:0010916)2.24513483
71Hyperalaninemia (HP:0003348)2.24513483
72Growth hormone excess (HP:0000845)2.23944400
73Abnormal hair whorl (HP:0010721)2.23932181
74Mucopolysacchariduria (HP:0008155)2.23850034
75Urinary glycosaminoglycan excretion (HP:0003541)2.23850034
76Bronchomalacia (HP:0002780)2.17874393
77Nuclear cataract (HP:0100018)2.17713842
78Hyperventilation (HP:0002883)2.17589022
79Dysmetric saccades (HP:0000641)2.17107580
80Gait imbalance (HP:0002141)2.14974504
81Depression (HP:0000716)2.14347333
82Supranuclear gaze palsy (HP:0000605)2.14149461
83Abnormal ossification of hand bones (HP:0005921)2.13897823
84Abnormal social behavior (HP:0012433)2.13818068
85Impaired social interactions (HP:0000735)2.13818068
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13084877
87Abnormality of polysaccharide metabolism (HP:0011012)2.13084877
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13084877
89Urinary urgency (HP:0000012)2.13036787
90Atrophy/Degeneration involving motor neurons (HP:0007373)2.12427718
91Systemic lupus erythematosus (HP:0002725)2.09111466
92Cervical subluxation (HP:0003308)2.09028372
93Truncal ataxia (HP:0002078)2.08957990
94Abnormal gallbladder physiology (HP:0012438)2.08775026
95Cholecystitis (HP:0001082)2.08775026
96Dialeptic seizures (HP:0011146)2.07754888
97Failure to thrive in infancy (HP:0001531)2.07273244
98Selective tooth agenesis (HP:0001592)2.07075153
99Mildly elevated creatine phosphokinase (HP:0008180)2.06766949
100Chromsome breakage (HP:0040012)2.06373363
101Dysdiadochokinesis (HP:0002075)2.06310464
102Centrally nucleated skeletal muscle fibers (HP:0003687)2.04563069
103Urinary bladder sphincter dysfunction (HP:0002839)2.02125624
104Apathy (HP:0000741)2.01729988
105Premature rupture of membranes (HP:0001788)2.01131399
106Xanthomatosis (HP:0000991)1.96977645
107Nephronophthisis (HP:0000090)1.95910128
108Lissencephaly (HP:0001339)1.93779238
109Ulnar bowing (HP:0003031)1.92200664
110Abnormality of complement system (HP:0005339)1.91545545
111Abnormal ciliary motility (HP:0012262)1.91310869
112Myopathic facies (HP:0002058)1.90912989
113Pointed chin (HP:0000307)1.89986610
114Retinal atrophy (HP:0001105)1.89611165
115Status epilepticus (HP:0002133)1.88627175
116Insomnia (HP:0100785)1.88343112
117Spinal cord compression (HP:0002176)1.88294933
118Diminished motivation (HP:0000745)1.87735230
119Right ventricular cardiomyopathy (HP:0011663)1.87449665
120Loss of speech (HP:0002371)1.86450831
121Distal sensory impairment (HP:0002936)1.85788122
122Impaired vibratory sensation (HP:0002495)1.85757855
123Amyloidosis (HP:0011034)1.85190258
124Rapidly progressive (HP:0003678)1.84529241
125Papilledema (HP:0001085)1.82518981
126Increased connective tissue (HP:0009025)1.81745843
127Coxa vara (HP:0002812)1.81030415
128Complement deficiency (HP:0004431)1.80307240
129Hypercholesterolemia (HP:0003124)1.79857624
130Abnormality of the labia minora (HP:0012880)1.79563606
131Hyperparathyroidism (HP:0000843)1.79486509
132Stereotypic behavior (HP:0000733)1.79444395
133Increased cerebral lipofuscin (HP:0011813)1.78453664
134Congenital primary aphakia (HP:0007707)1.77187652
135Torticollis (HP:0000473)1.76789435
136Protruding tongue (HP:0010808)1.76696878
137Shallow orbits (HP:0000586)1.75330060
138Hypoplasia of the brainstem (HP:0002365)1.75011636
139Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75011636
140Peripheral hypomyelination (HP:0007182)1.74649830
141Back pain (HP:0003418)1.74410440
142Severe global developmental delay (HP:0011344)1.72112594
143Athetosis (HP:0002305)1.72087297
144Action tremor (HP:0002345)1.71788597
145Poor suck (HP:0002033)1.71525354
146Sleep apnea (HP:0010535)1.70890258
147Abnormal hand bone ossification (HP:0010660)1.70172210
148Delusions (HP:0000746)1.69568866
149Skin nodule (HP:0200036)1.69548666
150Neonatal death (HP:0003811)1.68950715
151Medial flaring of the eyebrow (HP:0010747)1.68796568
152Abnormality of monocarboxylic acid metabolism (HP:0010996)1.68676610
153Nephrogenic diabetes insipidus (HP:0009806)1.67724664
154Excessive salivation (HP:0003781)1.67717876
155Drooling (HP:0002307)1.67717876
156Onion bulb formation (HP:0003383)1.67704845
157Aneurysm (HP:0002617)1.67601145
158Slow saccadic eye movements (HP:0000514)1.67578454
159Limb ataxia (HP:0002070)1.66736112
160Flattened epiphyses (HP:0003071)1.66044769
161Spastic gait (HP:0002064)1.64975171
162Degeneration of anterior horn cells (HP:0002398)1.64543537
163Abnormality of the anterior horn cell (HP:0006802)1.64543537
164Lymphangioma (HP:0100764)1.64416812
165Short nail (HP:0001799)1.63502867
166Abnormality of DNA repair (HP:0003254)1.63344792
167Hyperacusis (HP:0010780)1.63091771
168Mitral stenosis (HP:0001718)1.63005638
169Generalized hypopigmentation (HP:0007513)1.62904836
170Foot dorsiflexor weakness (HP:0009027)1.62686200
171Dementia (HP:0000726)1.62596146
172Hammertoe (HP:0001765)1.62046110
173Aplastic anemia (HP:0001915)1.61585203
174Mitral regurgitation (HP:0001653)1.60964623
175Aplasia/Hypoplasia of the uvula (HP:0010293)1.60203959
176Median cleft lip (HP:0000161)1.59501663
177Atrioventricular canal defect (HP:0006695)1.59384447
178Neoplasm of the heart (HP:0100544)1.59276923
179Nasal polyposis (HP:0100582)1.58862171
180Dysmetria (HP:0001310)1.58268055
181Epileptiform EEG discharges (HP:0011182)1.58263362
182Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.57705083
183Scanning speech (HP:0002168)1.56743844
184Abdominal distention (HP:0003270)1.56280418
185Malnutrition (HP:0004395)1.56216485
186Abnormality of glycolipid metabolism (HP:0010969)1.55965262
187Abnormality of glycosphingolipid metabolism (HP:0004343)1.55965262
188Narrow nasal bridge (HP:0000446)1.55727587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.40238219
2PRKD34.09062839
3NTRK33.60850805
4MARK13.29590430
5MAP3K93.23471934
6PDK43.19757071
7PDK33.19757071
8EPHA23.15078209
9NTRK23.06374860
10RIPK13.02757462
11EPHA42.91698597
12ERN12.74384499
13MAP3K42.62305319
14MAP2K72.61336439
15SIK12.57493602
16MST1R2.43058275
17MINK12.39268507
18FGFR42.18867858
19SMG11.97721813
20LMTK21.97295061
21TNIK1.93254421
22KSR11.89525283
23IRAK31.88946490
24TAOK21.76129926
25PKN21.68913815
26MAPK131.67466167
27NTRK11.65341230
28DAPK11.65254111
29PDK21.53668689
30SIK31.50871458
31PDGFRA1.45864760
32MAP3K121.42228419
33STK381.40202158
34TESK21.38700041
35SIK21.37614897
36EEF2K1.36970509
37PLK21.35329140
38KSR21.33745094
39CAMKK11.30351378
40MAP3K111.30170749
41PRPF4B1.29948729
42PHKG11.28471195
43PHKG21.28471195
44TESK11.27609277
45TAOK11.27122445
46PAK61.26974767
47BRAF1.22967272
48EPHB11.15711940
49NME21.14894204
50PTK21.14288739
51ICK1.12803949
52PRKCG1.10752219
53PDPK11.10106371
54NEK11.08636171
55PNCK1.07200157
56CCNB11.06286559
57MET1.06262364
58CDK51.05460389
59CDC71.03113026
60ARAF1.02254781
61NME11.01669561
62MAP2K41.01413094
63PTK61.00314164
64TNK20.99322372
65CASK0.98968081
66LATS20.98816484
67PAK40.97831495
68RAF10.97730688
69TTN0.97374959
70BRSK10.97077507
71TSSK60.94261986
72TYRO30.93926756
73DDR20.92735131
74MAP3K130.92695042
75LIMK10.92232790
76DAPK20.91447205
77CDK180.82618903
78CAMK10.81458100
79MAP3K30.80991300
80ALK0.80070402
81BMX0.78210602
82CDK150.76041349
83MAP3K10.75385059
84IRAK20.73605892
85PINK10.73492878
86NEK20.72617960
87FES0.71261449
88PRKG20.71228464
89CDK120.69969740
90PRKCH0.68782481
91CDK11A0.68597748
92WNK30.67699255
93PDK10.67438377
94RET0.66854342
95MAP2K60.66251253
96AKT30.64808665
97MAPK110.63790651
98MTOR0.62987568
99EIF2AK10.61956815
100FGFR30.60526901
101MAP2K30.57672065
102RPS6KB10.57220672
103ATR0.57006018
104CAMKK20.56435383
105PIM20.54468483
106CDK190.52359441
107CDK140.52117979
108MAP3K20.51003849
109SGK20.50336244
110CAMK2B0.49341938
111DYRK1A0.49003575
112SCYL20.48614111
113CAMK2G0.48468870
114MARK20.48330961
115STK110.48194285
116RIPK40.46933730
117CDC42BPA0.45972763
118GRK60.43913934
119SGK30.43866042
120RPS6KA20.43676700
121DYRK1B0.42408118
122STK160.41260769
123MAPK120.40939062
124PRKD20.40409152
125GRK50.39655948
126SYK0.39608879
127CAMK2A0.39540587
128EPHB20.39097323
129MAP2K20.38518437
130NEK60.37363656
131TBK10.36708571
132MAPKAPK30.36529919
133PLK10.36383109
134ERBB20.35925561
135SRC0.35540636
136CHEK20.34438442
137MAP3K50.34364444
138PRKD10.34092917
139UHMK10.33737258
140MAP3K70.33056483
141CAMK1D0.31731974
142MAP3K60.31671306
143TXK0.31193767
144DAPK30.31026995
145MAPK100.30960672
146MATK0.30408075
147CHEK10.30303290
148PTK2B0.30175302
149PLK40.29456574
150PRKCI0.28595955
151PLK30.27226896
152HCK0.23808716

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82516942
2Synaptic vesicle cycle_Homo sapiens_hsa047212.98756080
3Other glycan degradation_Homo sapiens_hsa005112.65637600
4Long-term potentiation_Homo sapiens_hsa047202.63800257
5Olfactory transduction_Homo sapiens_hsa047402.52206529
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.44536476
7Circadian entrainment_Homo sapiens_hsa047132.41121182
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.39434322
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34237369
10Morphine addiction_Homo sapiens_hsa050322.26570972
11GABAergic synapse_Homo sapiens_hsa047272.19660076
12Glutamatergic synapse_Homo sapiens_hsa047242.14040738
13Amphetamine addiction_Homo sapiens_hsa050312.08036588
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04175227
15Salivary secretion_Homo sapiens_hsa049701.89600831
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87046903
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.71878078
18Oocyte meiosis_Homo sapiens_hsa041141.69761245
19Insulin secretion_Homo sapiens_hsa049111.68969317
20Dopaminergic synapse_Homo sapiens_hsa047281.65141919
21Calcium signaling pathway_Homo sapiens_hsa040201.63758518
22Taste transduction_Homo sapiens_hsa047421.59544084
23Galactose metabolism_Homo sapiens_hsa000521.56444492
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56348443
25Gastric acid secretion_Homo sapiens_hsa049711.54022732
26Arginine biosynthesis_Homo sapiens_hsa002201.47642841
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43898271
28Prion diseases_Homo sapiens_hsa050201.39639551
29Oxytocin signaling pathway_Homo sapiens_hsa049211.34770561
30Renin secretion_Homo sapiens_hsa049241.32528148
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.29223082
32Bile secretion_Homo sapiens_hsa049761.27945262
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27692267
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27500192
35Cholinergic synapse_Homo sapiens_hsa047251.26767931
36DNA replication_Homo sapiens_hsa030301.20038833
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18444184
38Vitamin B6 metabolism_Homo sapiens_hsa007501.18178527
39Long-term depression_Homo sapiens_hsa047301.17547527
40Biosynthesis of amino acids_Homo sapiens_hsa012301.17053425
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13948396
42Base excision repair_Homo sapiens_hsa034101.12207648
43Pentose phosphate pathway_Homo sapiens_hsa000301.12043177
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09868113
45Fatty acid biosynthesis_Homo sapiens_hsa000611.09773551
46Arginine and proline metabolism_Homo sapiens_hsa003301.09540759
47Phenylalanine metabolism_Homo sapiens_hsa003601.09516272
48Gap junction_Homo sapiens_hsa045401.09267035
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06885786
50Serotonergic synapse_Homo sapiens_hsa047261.06604754
51GnRH signaling pathway_Homo sapiens_hsa049121.06488349
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06032596
53Sulfur relay system_Homo sapiens_hsa041221.05330059
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04005174
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03610747
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03086239
57cAMP signaling pathway_Homo sapiens_hsa040241.02668253
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01708584
59Collecting duct acid secretion_Homo sapiens_hsa049661.01191052
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00406113
61Cocaine addiction_Homo sapiens_hsa050300.99936365
62Lysosome_Homo sapiens_hsa041420.99690286
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99517832
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98371562
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97951061
66Histidine metabolism_Homo sapiens_hsa003400.97468906
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97407929
68Estrogen signaling pathway_Homo sapiens_hsa049150.96733418
69Fat digestion and absorption_Homo sapiens_hsa049750.95993359
70mRNA surveillance pathway_Homo sapiens_hsa030150.93441483
71PPAR signaling pathway_Homo sapiens_hsa033200.92528883
72Vitamin digestion and absorption_Homo sapiens_hsa049770.92335680
73AMPK signaling pathway_Homo sapiens_hsa041520.91328076
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88044338
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87523270
76Glucagon signaling pathway_Homo sapiens_hsa049220.87096563
77Melanogenesis_Homo sapiens_hsa049160.85910275
78Cardiac muscle contraction_Homo sapiens_hsa042600.85828958
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85732932
80Fanconi anemia pathway_Homo sapiens_hsa034600.85577455
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85539035
82Notch signaling pathway_Homo sapiens_hsa043300.85498900
83Glioma_Homo sapiens_hsa052140.84356055
84Endocytosis_Homo sapiens_hsa041440.83778545
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83133052
86Complement and coagulation cascades_Homo sapiens_hsa046100.81749653
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81619019
88RNA transport_Homo sapiens_hsa030130.80418562
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79809742
90ErbB signaling pathway_Homo sapiens_hsa040120.78301348
91Carbon metabolism_Homo sapiens_hsa012000.77447225
92Mismatch repair_Homo sapiens_hsa034300.77355071
93Vibrio cholerae infection_Homo sapiens_hsa051100.76920170
94Chronic myeloid leukemia_Homo sapiens_hsa052200.75124570
95N-Glycan biosynthesis_Homo sapiens_hsa005100.74537255
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.72083341
97Bladder cancer_Homo sapiens_hsa052190.71129500
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70988739
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70279552
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67505768
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.66672911
102Acute myeloid leukemia_Homo sapiens_hsa052210.66525166
103Mineral absorption_Homo sapiens_hsa049780.63782694
104Renin-angiotensin system_Homo sapiens_hsa046140.60672668
105Colorectal cancer_Homo sapiens_hsa052100.58869566
106Type II diabetes mellitus_Homo sapiens_hsa049300.58644627
107Focal adhesion_Homo sapiens_hsa045100.58263891
108Non-small cell lung cancer_Homo sapiens_hsa052230.58152986
109mTOR signaling pathway_Homo sapiens_hsa041500.57832969
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57334121
111Inositol phosphate metabolism_Homo sapiens_hsa005620.56777425
112Endometrial cancer_Homo sapiens_hsa052130.56683705
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56298752
114* Purine metabolism_Homo sapiens_hsa002300.56024591
115Sphingolipid metabolism_Homo sapiens_hsa006000.55981933
116Insulin signaling pathway_Homo sapiens_hsa049100.55774149
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.55527109
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.55361864
119Type I diabetes mellitus_Homo sapiens_hsa049400.54757446
120Insulin resistance_Homo sapiens_hsa049310.54629387
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53581315
122MAPK signaling pathway_Homo sapiens_hsa040100.53470277
123Spliceosome_Homo sapiens_hsa030400.53438530
124Fatty acid metabolism_Homo sapiens_hsa012120.53265595
125VEGF signaling pathway_Homo sapiens_hsa043700.53177537
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.52816339
127Salmonella infection_Homo sapiens_hsa051320.52568922
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51974834
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50693473
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49741058
131Tight junction_Homo sapiens_hsa045300.48889500
132Wnt signaling pathway_Homo sapiens_hsa043100.48658443
133Fructose and mannose metabolism_Homo sapiens_hsa000510.48373526
134Alcoholism_Homo sapiens_hsa050340.48354995
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47787929
136Pancreatic secretion_Homo sapiens_hsa049720.47324385
137Axon guidance_Homo sapiens_hsa043600.47178298
138T cell receptor signaling pathway_Homo sapiens_hsa046600.46680809
139RNA polymerase_Homo sapiens_hsa030200.46513731
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.46266315
141Dorso-ventral axis formation_Homo sapiens_hsa043200.46081352
142* Pyrimidine metabolism_Homo sapiens_hsa002400.46041932
143Primary immunodeficiency_Homo sapiens_hsa053400.45625380
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44964540
145Thyroid hormone synthesis_Homo sapiens_hsa049180.44815629
146Non-homologous end-joining_Homo sapiens_hsa034500.43912126
147Cell cycle_Homo sapiens_hsa041100.43775705
148Choline metabolism in cancer_Homo sapiens_hsa052310.41424712

Most similar genes based on co-expression Upload to Enrichr

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