ENTPD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.89758658
2cell adhesion mediated by integrin (GO:0033627)5.55554062
3Golgi transport vesicle coating (GO:0048200)5.26800985
4COPI coating of Golgi vesicle (GO:0048205)5.26800985
5signal peptide processing (GO:0006465)5.25708253
6intestinal cholesterol absorption (GO:0030299)5.09831563
7oligosaccharide catabolic process (GO:0009313)4.72613270
8desmosome organization (GO:0002934)4.41937312
9COPII vesicle coating (GO:0048208)4.40250889
10angiotensin maturation (GO:0002003)4.36842439
11skin morphogenesis (GO:0043589)4.16707591
12response to peptidoglycan (GO:0032494)4.10733961
13cell-substrate junction assembly (GO:0007044)4.10379881
14embryonic process involved in female pregnancy (GO:0060136)3.98193755
15intestinal absorption (GO:0050892)3.96777111
16nuclear pore complex assembly (GO:0051292)3.96571556
17protein localization to endosome (GO:0036010)3.91828376
18neutrophil activation involved in immune response (GO:0002283)3.90729417
19endodermal cell differentiation (GO:0035987)3.85634733
20bundle of His cell to Purkinje myocyte communication (GO:0086069)3.78900908
21dendritic cell chemotaxis (GO:0002407)3.75115125
22superoxide anion generation (GO:0042554)3.60151022
23nuclear pore organization (GO:0006999)3.56536645
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56414618
25regulation of transforming growth factor beta1 production (GO:0032908)3.52106855
26regulation of vitamin metabolic process (GO:0030656)3.48811305
27dendritic cell migration (GO:0036336)3.43436317
28glycolipid catabolic process (GO:0019377)3.34874980
29nucleotide-sugar biosynthetic process (GO:0009226)3.34046689
30polyketide metabolic process (GO:0030638)3.33660093
31doxorubicin metabolic process (GO:0044598)3.33660093
32daunorubicin metabolic process (GO:0044597)3.33660093
33protein retention in ER lumen (GO:0006621)3.33433730
34neutrophil mediated immunity (GO:0002446)3.27352494
35mesodermal cell differentiation (GO:0048333)3.26817271
36vesicle coating (GO:0006901)3.26406499
37ceramide catabolic process (GO:0046514)3.24886974
38regulation of vitamin D biosynthetic process (GO:0060556)3.22022617
39UDP-N-acetylglucosamine metabolic process (GO:0006047)3.17431552
40digestion (GO:0007586)3.15645159
41hypotonic response (GO:0006971)3.12450229
42neutrophil activation (GO:0042119)3.09134302
43pore complex assembly (GO:0046931)3.08136041
44negative regulation of fatty acid transport (GO:2000192)3.04322681
45wound healing, spreading of epidermal cells (GO:0035313)3.04011575
46histamine secretion (GO:0001821)3.03807688
47energy homeostasis (GO:0097009)3.03401705
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93563374
49respiratory burst (GO:0045730)2.90786846
50glycosphingolipid catabolic process (GO:0046479)2.89551314
51regulation of transforming growth factor beta2 production (GO:0032909)2.87985780
52dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.85473801
53negative regulation of mast cell activation (GO:0033004)2.84912530
54cellular response to vitamin D (GO:0071305)2.84767428
55granulocyte activation (GO:0036230)2.84508262
56cellular protein complex localization (GO:0034629)2.82515631
57myeloid leukocyte mediated immunity (GO:0002444)2.82394907
58negative regulation of keratinocyte proliferation (GO:0010839)2.81356448
59midgut development (GO:0007494)2.80955621
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77118894
61positive regulation by symbiont of host defense response (GO:0052509)2.76685724
62modulation by symbiont of host defense response (GO:0052031)2.76685724
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76685724
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76685724
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.76685724
66modulation by symbiont of host immune response (GO:0052553)2.76685724
67mammary gland epithelial cell proliferation (GO:0033598)2.74812144
68branching involved in mammary gland duct morphogenesis (GO:0060444)2.73045139
69regulation of water loss via skin (GO:0033561)2.72835426
70positive regulation of endothelial cell apoptotic process (GO:2000353)2.72381861
71iron ion import (GO:0097286)2.71059986
72epithelial cell-cell adhesion (GO:0090136)2.69789413
73regulation of cholesterol homeostasis (GO:2000188)2.68623830
74response to muramyl dipeptide (GO:0032495)2.67475626
75gap junction assembly (GO:0016264)2.67361507
76regulation of germinal center formation (GO:0002634)2.65789007
77negative regulation of anoikis (GO:2000811)2.65783117
78peptide hormone processing (GO:0016486)2.65190004
79regulation of mast cell activation (GO:0033003)2.64936888
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64190369
81membrane protein ectodomain proteolysis (GO:0006509)2.64130324
82urea cycle (GO:0000050)2.63272446
83regulation of interleukin-8 secretion (GO:2000482)2.63118061
84regulation of activation of Janus kinase activity (GO:0010533)2.61943500
85positive regulation of T cell migration (GO:2000406)2.60947000
86immunoglobulin mediated immune response (GO:0016064)2.60875218
87negative regulation of viral genome replication (GO:0045071)2.60800006
88eosinophil chemotaxis (GO:0048245)2.60668350
89collagen fibril organization (GO:0030199)2.60441387
90multicellular organismal macromolecule metabolic process (GO:0044259)2.60157878
91mesenchymal cell differentiation involved in kidney development (GO:0072161)2.59792651
92mesenchymal cell differentiation involved in renal system development (GO:2001012)2.59792651
93wound healing, spreading of cells (GO:0044319)2.59614415
94heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.59199986
95reactive oxygen species biosynthetic process (GO:1903409)2.58472399
96multicellular organismal metabolic process (GO:0044236)2.57363597
97regulation of cellular extravasation (GO:0002691)2.56950718
98mannosylation (GO:0097502)2.56594404
99positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56393611
100sphingomyelin metabolic process (GO:0006684)2.54750319
101regulation of early endosome to late endosome transport (GO:2000641)2.54672058
102regulation of mast cell degranulation (GO:0043304)2.54662112
103positive regulation of antigen processing and presentation (GO:0002579)2.54326655
104adherens junction assembly (GO:0034333)2.53446656
105dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.53264515
106GDP-mannose metabolic process (GO:0019673)2.52659257
107endoplasmic reticulum unfolded protein response (GO:0030968)2.52451747
108urea metabolic process (GO:0019627)2.52021288
109multicellular organismal catabolic process (GO:0044243)2.51753493
110developmental pigmentation (GO:0048066)2.50593018
111activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50259130
112natural killer cell activation involved in immune response (GO:0002323)2.50113826
113hyaluronan catabolic process (GO:0030214)2.49767491
114retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49575685
115presynaptic membrane assembly (GO:0097105)2.49261317
116regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48457637
117proline biosynthetic process (GO:0006561)2.48361262
118regulation of antigen processing and presentation (GO:0002577)2.48329529
119regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48238023
120hydrogen peroxide biosynthetic process (GO:0050665)2.47470040
121protein hydroxylation (GO:0018126)2.47183880
122cellular response to vitamin (GO:0071295)2.46724831
123regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.46270383
124regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.46189082
125membrane lipid catabolic process (GO:0046466)2.45631312
126regulation of mast cell activation involved in immune response (GO:0033006)2.45209349
127G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.45035703
128leukotriene metabolic process (GO:0006691)2.44948783
129extracellular matrix disassembly (GO:0022617)2.44916731
130glycoside metabolic process (GO:0016137)2.44803141
131collagen metabolic process (GO:0032963)2.44800396
132regulation of T cell receptor signaling pathway (GO:0050856)2.44434803
133mature B cell differentiation (GO:0002335)2.44043950
134cell-substrate adherens junction assembly (GO:0007045)2.43759969
135focal adhesion assembly (GO:0048041)2.43759969
136leukocyte aggregation (GO:0070486)2.43675250
137ER-nucleus signaling pathway (GO:0006984)2.43660793
138mature B cell differentiation involved in immune response (GO:0002313)2.43427484
139positive regulation of defense response to virus by host (GO:0002230)2.42966243
140basement membrane organization (GO:0071711)2.42385896
141protein N-linked glycosylation via asparagine (GO:0018279)2.42026070
142nucleotide transmembrane transport (GO:1901679)2.41871586
143mitochondrial calcium ion transport (GO:0006851)2.41632257
144sphingolipid catabolic process (GO:0030149)2.41506799
145peptidyl-asparagine modification (GO:0018196)2.41471210
146regulation of pigment cell differentiation (GO:0050932)2.41313863
147positive regulation of nuclease activity (GO:0032075)2.40929426
148pinocytosis (GO:0006907)2.40514218
149establishment of skin barrier (GO:0061436)2.40508415
150positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.39661411
151regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.39229836
152substrate-dependent cell migration (GO:0006929)2.39058506
153superoxide metabolic process (GO:0006801)2.38896613
154regulation of fever generation (GO:0031620)2.38261481
155regulation of transforming growth factor beta production (GO:0071634)2.38016254
156negative regulation of chondrocyte differentiation (GO:0032331)2.37771738
157chondrocyte proliferation (GO:0035988)2.37245845
158very-low-density lipoprotein particle assembly (GO:0034379)2.37151420
159positive regulation of lymphocyte migration (GO:2000403)2.36301068
160response to laminar fluid shear stress (GO:0034616)2.35365403
161peptidyl-proline hydroxylation (GO:0019511)2.35127847
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35060295
163response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.34920621
164response to host immune response (GO:0052572)2.34920621
165positive regulation of interleukin-1 beta secretion (GO:0050718)2.34079739
166eosinophil migration (GO:0072677)2.33897230
167positive regulation of osteoblast proliferation (GO:0033690)2.33769141
168surfactant homeostasis (GO:0043129)2.33695266
169cellular response to unfolded protein (GO:0034620)2.33207572
170negative regulation of protein localization to plasma membrane (GO:1903077)2.32913926
171cytochrome complex assembly (GO:0017004)2.32400767
172type I interferon signaling pathway (GO:0060337)2.32261013
173cellular response to type I interferon (GO:0071357)2.32261013
174omega-hydroxylase P450 pathway (GO:0097267)2.32183284
175protein N-linked glycosylation (GO:0006487)2.31672793
176positive regulation of interleukin-17 production (GO:0032740)2.31606639
177positive regulation of mast cell degranulation (GO:0043306)2.31555317
178positive regulation of mast cell activation involved in immune response (GO:0033008)2.31555317
179collagen catabolic process (GO:0030574)2.31103510
180purinergic nucleotide receptor signaling pathway (GO:0035590)2.30980597
181histamine transport (GO:0051608)2.30599701
182adhesion of symbiont to host cell (GO:0044650)2.30580408
183virion attachment to host cell (GO:0019062)2.30580408
184negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.30284576
185peptide catabolic process (GO:0043171)2.30210776
186myeloid dendritic cell activation (GO:0001773)2.29695520
187cellular response to exogenous dsRNA (GO:0071360)2.29657313
188sulfate transmembrane transport (GO:1902358)2.28803446
189response to type I interferon (GO:0034340)2.28769736
190cellular response to interferon-beta (GO:0035458)2.28291466
191toxin transport (GO:1901998)2.28208700
192chondrocyte development (GO:0002063)2.28132047
193I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.28008599
194production of molecular mediator involved in inflammatory response (GO:0002532)2.26936205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.59773085
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.00221267
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.99499528
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.93723924
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.86335548
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.71233314
7E2F7_22180533_ChIP-Seq_HELA_Human3.17362900
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99753284
9AR_21909140_ChIP-Seq_LNCAP_Human2.78606729
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73063239
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.72772107
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.72772107
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71556403
14CLOCK_20551151_ChIP-Seq_293T_Human2.66050965
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.63133872
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.58536588
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54595094
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.53720969
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33838577
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.31634518
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.29590773
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.28782446
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27346386
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24669035
25* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.17666895
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14355648
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09560005
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.08197451
29SUZ12_27294783_Chip-Seq_NPCs_Mouse2.05169217
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.04774926
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99553170
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.99292813
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.99257671
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.97208592
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.96939885
36* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92910837
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92660926
38* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90692135
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87491466
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.87301021
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86711905
42GBX2_23144817_ChIP-Seq_PC3_Human1.86348517
43* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.85922519
44IRF1_19129219_ChIP-ChIP_H3396_Human1.83493035
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.83157109
46* BRD4_25478319_ChIP-Seq_HGPS_Human1.83132105
47* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.80494747
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.79812292
49ZNF263_19887448_ChIP-Seq_K562_Human1.79172612
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.78813616
51UBF1/2_26484160_Chip-Seq_HMECs_Human1.77373798
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76969632
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.74752162
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73921071
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72648661
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.71939288
57STAT3_18555785_Chip-Seq_ESCs_Mouse1.70879805
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69907924
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.69342391
60* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.68499458
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65002624
62P53_22387025_ChIP-Seq_ESCs_Mouse1.64136925
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61981537
64NMYC_18555785_Chip-Seq_ESCs_Mouse1.61568679
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61205420
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60987768
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60906676
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60359441
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58566812
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55667221
71SPI1_23547873_ChIP-Seq_NB4_Human1.54512819
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.53177184
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.52718582
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52156205
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52127442
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51886445
77ATF3_27146783_Chip-Seq_COLON_Human1.51582217
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.50946306
79CJUN_26792858_Chip-Seq_BT549_Human1.50238668
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49443099
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47316108
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47257007
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.45496907
84IGF1R_20145208_ChIP-Seq_DFB_Human1.44470681
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.43288459
86P300_18555785_Chip-Seq_ESCs_Mouse1.42217358
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.42075847
88GATA6_25053715_ChIP-Seq_YYC3_Human1.41911107
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.41710992
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41697850
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.41520143
92ZFX_18555785_Chip-Seq_ESCs_Mouse1.41439907
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40844124
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.40584475
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.40248715
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.39967256
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38954145
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35421984
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34607734
100PU1_27457419_Chip-Seq_LIVER_Mouse1.34388610
101SMAD1_18555785_Chip-Seq_ESCs_Mouse1.34194122
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34191994
103ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33813299
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32205448
105ELK1_19687146_ChIP-ChIP_HELA_Human1.31014897
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30835086
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30632808
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28720188
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.27983294
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26563055
111MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24774111
112P300_19829295_ChIP-Seq_ESCs_Human1.24026304
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23507661
114* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23187759
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.22163694
116VDR_24787735_ChIP-Seq_THP-1_Human1.21915399
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21176289
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20777033
119* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20667631
120* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20439107
121KLF4_18555785_Chip-Seq_ESCs_Mouse1.20326836
122PU_27001747_Chip-Seq_BMDM_Mouse1.19729363
123TFEB_21752829_ChIP-Seq_HELA_Human1.18810548
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.18177855
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17931709
126CTCF_18555785_Chip-Seq_ESCs_Mouse1.15499558
127OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15127179
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14771691
129* TP63_23658742_ChIP-Seq_EP156T_Human1.14053447
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.13655426
131* GATA4_25053715_ChIP-Seq_YYC3_Human1.13602184
132FOXM1_23109430_ChIP-Seq_U2OS_Human1.13024501
133RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12883749
134HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12671807
135RXR_22158963_ChIP-Seq_LIVER_Mouse1.11534110
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11016894
137SCL_19346495_ChIP-Seq_HPC-7_Human1.10997805
138STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10232750
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09949794
140NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09739180
141SOX2_20726797_ChIP-Seq_SW620_Human1.09478231
142GABP_17652178_ChIP-ChIP_JURKAT_Human1.09198951
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09014745
144* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08489065
145HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07185969
146BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06946287
147VDR_22108803_ChIP-Seq_LS180_Human1.06908430
148LXR_22158963_ChIP-Seq_LIVER_Mouse1.06338006
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06294510
150GATA1_22025678_ChIP-Seq_K562_Human1.05801877
151* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05516029
152RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05493733
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05339511
154ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04057686
155RUNX_20019798_ChIP-Seq_JUKART_Human1.03452695
156RACK7_27058665_Chip-Seq_MCF-7_Human1.03408088
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03174622
158HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02700608
159HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02240982
160CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02146905
161ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01696702
162ESR1_20079471_ChIP-ChIP_T-47D_Human1.01511866
163EWS_26573619_Chip-Seq_HEK293_Human1.01287413
164ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00870132
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00311966
166ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00111506
167CHD1_26751641_Chip-Seq_LNCaP_Human1.00067229
168NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99311554
169CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97214295
170SRF_21415370_ChIP-Seq_HL-1_Mouse0.97210266
171NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96259533
172NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96259533
173TP53_22127205_ChIP-Seq_IMR90_Human0.95656643
174POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94802336
175PIAS1_25552417_ChIP-Seq_VCAP_Human0.94671049
176HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94146965
177MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94030733
178CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93555308
179TP63_17297297_ChIP-ChIP_HaCaT_Human0.91839231
180FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91798291
181TCF4_18268006_ChIP-ChIP_LS174T_Human0.91273964
182KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91052415
183SOX17_20123909_ChIP-Seq_XEN_Mouse0.90807903
184TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90734593
185TP53_18474530_ChIP-ChIP_U2OS_Human0.90332004
186TP53_16413492_ChIP-PET_HCT116_Human0.90107609
187PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90056720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.26932721
2MP0010352_gastrointestinal_tract_polyps3.71138010
3MP0003705_abnormal_hypodermis_morpholog3.45796345
4MP0003183_abnormal_peptide_metabolism3.43700066
5MP0001188_hyperpigmentation3.35823093
6MP0004272_abnormal_basement_membrane3.26740386
7MP0003566_abnormal_cell_adhesion3.26185379
8MP0003136_yellow_coat_color3.25056842
9MP0010234_abnormal_vibrissa_follicle3.12849553
10MP0000015_abnormal_ear_pigmentation3.12223579
11MP0001835_abnormal_antigen_presentation3.00601810
12MP0005275_abnormal_skin_tensile2.98294308
13MP0002148_abnormal_hypersensitivity_rea2.83490595
14MP0005174_abnormal_tail_pigmentation2.80550624
15MP0005409_darkened_coat_color2.69587517
16MP0009785_altered_susceptibility_to2.55672856
17MP0001986_abnormal_taste_sensitivity2.36268310
18MP0001666_abnormal_nutrient_absorption2.35981343
19MP0005084_abnormal_gallbladder_morpholo2.31329337
20MP0005671_abnormal_response_to2.30844124
21MP0003436_decreased_susceptibility_to2.26743994
22MP0002277_abnormal_respiratory_mucosa2.25465166
23MP0005360_urolithiasis2.25267449
24MP0003724_increased_susceptibility_to2.19155665
25MP0009840_abnormal_foam_cell2.16804003
26MP0005000_abnormal_immune_tolerance2.15797533
27MP0000566_synostosis2.15414872
28MP0002796_impaired_skin_barrier2.10815529
29MP0005171_absent_coat_pigmentation2.08433810
30MP0002060_abnormal_skin_morphology2.07049086
31MP0002419_abnormal_innate_immunity2.06421034
32MP0005451_abnormal_body_composition2.04530529
33MP0006292_abnormal_olfactory_placode2.02231095
34MP0002009_preneoplasia2.02178870
35MP0003091_abnormal_cell_migration1.99917735
36MP0003950_abnormal_plasma_membrane1.94669883
37MP0000579_abnormal_nail_morphology1.93152594
38MP0005023_abnormal_wound_healing1.92962638
39MP0003191_abnormal_cellular_cholesterol1.88816127
40MP0005257_abnormal_intraocular_pressure1.87237024
41MP0009379_abnormal_foot_pigmentation1.86171753
42MP0005645_abnormal_hypothalamus_physiol1.84133162
43MP0003453_abnormal_keratinocyte_physiol1.83881925
44MP0005025_abnormal_response_to1.83841684
45MP0001790_abnormal_immune_system1.80914939
46MP0005387_immune_system_phenotype1.80914939
47MP0010386_abnormal_urinary_bladder1.76826660
48MP0006054_spinal_hemorrhage1.76738242
49MP0002452_abnormal_antigen_presenting1.75528743
50MP0000490_abnormal_crypts_of1.73787119
51MP0002876_abnormal_thyroid_physiology1.73772201
52MP0002163_abnormal_gland_morphology1.73357372
53MP0005623_abnormal_meninges_morphology1.71000032
54MP0002723_abnormal_immune_serum1.64323867
55MP0004782_abnormal_surfactant_physiolog1.64215057
56MP0009333_abnormal_splenocyte_physiolog1.61629088
57MP0002420_abnormal_adaptive_immunity1.61101344
58MP0001819_abnormal_immune_cell1.60984820
59MP0003300_gastrointestinal_ulcer1.58858953
60MP0005076_abnormal_cell_differentiation1.57145714
61MP0005501_abnormal_skin_physiology1.55492529
62MP0010368_abnormal_lymphatic_system1.55187720
63MP0001800_abnormal_humoral_immune1.54002034
64MP0002693_abnormal_pancreas_physiology1.52803460
65MP0010678_abnormal_skin_adnexa1.51064013
66MP0001849_ear_inflammation1.50768518
67MP0006082_CNS_inflammation1.49885028
68MP0002095_abnormal_skin_pigmentation1.47781309
69MP0001216_abnormal_epidermal_layer1.46716413
70MP0010155_abnormal_intestine_physiology1.45257532
71MP0005310_abnormal_salivary_gland1.45124414
72MP0004381_abnormal_hair_follicle1.44023663
73MP0005379_endocrine/exocrine_gland_phen1.43628358
74MP0002638_abnormal_pupillary_reflex1.41855329
75MP0000372_irregular_coat_pigmentation1.40790868
76MP0003763_abnormal_thymus_physiology1.39335717
77MP0003868_abnormal_feces_composition1.38973805
78MP0000762_abnormal_tongue_morphology1.36483327
79MP0002132_abnormal_respiratory_system1.36118119
80MP0003866_abnormal_defecation1.34523323
81MP0008260_abnormal_autophagy1.31550177
82MP0009697_abnormal_copulation1.30103867
83MP0004264_abnormal_extraembryonic_tissu1.29970307
84MP0003279_aneurysm1.27901342
85MP0001533_abnormal_skeleton_physiology1.24817168
86MP0002405_respiratory_system_inflammati1.24396265
87MP0000681_abnormal_thyroid_gland1.23474585
88MP0000467_abnormal_esophagus_morphology1.21669025
89MP0001915_intracranial_hemorrhage1.21420570
90MP0005367_renal/urinary_system_phenotyp1.21071560
91MP0000516_abnormal_urinary_system1.21071560
92MP0003941_abnormal_skin_development1.19866884
93MP0001845_abnormal_inflammatory_respons1.19336615
94MP0000537_abnormal_urethra_morphology1.17540809
95MP0008004_abnormal_stomach_pH1.16752373
96MP0004947_skin_inflammation1.16675783
97MP0002139_abnormal_hepatobiliary_system1.13484150
98MP0010307_abnormal_tumor_latency1.13113398
99MP0009053_abnormal_anal_canal1.11705306
100MP0005646_abnormal_pituitary_gland1.10624111
101MP0002896_abnormal_bone_mineralization1.10602408
102MP0004233_abnormal_muscle_weight1.10263239
103MP0000716_abnormal_immune_system1.08805595
104MP0002006_tumorigenesis1.08114693
105MP0009384_cardiac_valve_regurgitation1.07364129
106MP0001873_stomach_inflammation1.06658524
107MP0005058_abnormal_lysosome_morphology1.05903076
108MP0001663_abnormal_digestive_system1.05647321
109MP0005464_abnormal_platelet_physiology1.02647062
110MP0002166_altered_tumor_susceptibility1.02199242
111MP0000685_abnormal_immune_system1.01795076
112MP0001664_abnormal_digestion1.01538571
113MP0002933_joint_inflammation1.01527533
114MP0002086_abnormal_extraembryonic_tissu1.01332563
115MP0005075_abnormal_melanosome_morpholog1.01100333
116MP0005085_abnormal_gallbladder_physiolo0.98787840
117MP0000678_abnormal_parathyroid_gland0.98228049
118MP0002998_abnormal_bone_remodeling0.98106784
119MP0005220_abnormal_exocrine_pancreas0.97650634
120MP0001186_pigmentation_phenotype0.97620018
121MP0000767_abnormal_smooth_muscle0.97514474
122MP0005621_abnormal_cell_physiology0.97354390
123MP0002398_abnormal_bone_marrow0.96540398
124MP0010771_integument_phenotype0.94472752
125MP0005390_skeleton_phenotype0.94174340
126MP0000383_abnormal_hair_follicle0.94093091
127MP0000538_abnormal_urinary_bladder0.93287501
128MP0004957_abnormal_blastocyst_morpholog0.92504847
129MP0000627_abnormal_mammary_gland0.91912146
130MP0000858_altered_metastatic_potential0.89236114
131MP0005197_abnormal_uvea_morphology0.88973710
132MP0002751_abnormal_autonomic_nervous0.88947096
133MP0001958_emphysema0.88834454
134MP0000613_abnormal_salivary_gland0.88061007
135MP0001243_abnormal_dermal_layer0.87530417
136MP0003656_abnormal_erythrocyte_physiolo0.87133157
137MP0005408_hypopigmentation0.86421565
138MP0008057_abnormal_DNA_replication0.86336514
139MP0001730_embryonic_growth_arrest0.86301146
140MP0008469_abnormal_protein_level0.82694634
141MP0002429_abnormal_blood_cell0.81405211
142MP0000377_abnormal_hair_follicle0.80664325
143MP0009931_abnormal_skin_appearance0.80440037
144MP0003828_pulmonary_edema0.79230710
145MP0002877_abnormal_melanocyte_morpholog0.79042411
146MP0000733_abnormal_muscle_development0.78875727
147MP0005381_digestive/alimentary_phenotyp0.78364094
148MP0005365_abnormal_bile_salt0.77822861
149MP0001191_abnormal_skin_condition0.77673943
150MP0004147_increased_porphyrin_level0.77356245
151MP0008007_abnormal_cellular_replicative0.75029311
152MP0003984_embryonic_growth_retardation0.74751845
153MP0002938_white_spotting0.74560163
154MP0000350_abnormal_cell_proliferation0.74207994
155MP0004185_abnormal_adipocyte_glucose0.73401199
156MP0003385_abnormal_body_wall0.73250625
157MP0000470_abnormal_stomach_morphology0.73244193
158MP0001672_abnormal_embryogenesis/_devel0.72719644
159MP0005380_embryogenesis_phenotype0.72719644
160MP0000049_abnormal_middle_ear0.72047954
161MP0003303_peritoneal_inflammation0.71895891
162MP0002177_abnormal_outer_ear0.71742518
163MP0000689_abnormal_spleen_morphology0.71574970
164MP0003795_abnormal_bone_structure0.71434305
165MP0008932_abnormal_embryonic_tissue0.71425296
166MP0001346_abnormal_lacrimal_gland0.70470930
167MP0005164_abnormal_response_to0.70337037
168MP0002098_abnormal_vibrissa_morphology0.69958704
169MP0002088_abnormal_embryonic_growth/wei0.69934079
170MP0009764_decreased_sensitivity_to0.69777201
171MP0001299_abnormal_eye_distance/0.69048873
172MP0002254_reproductive_system_inflammat0.68269969
173MP0002084_abnormal_developmental_patter0.67379438
174MP0003448_altered_tumor_morphology0.67293960
175MP0004858_abnormal_nervous_system0.67118529
176MP0000013_abnormal_adipose_tissue0.66144101
177MP0002697_abnormal_eye_size0.66105419
178MP0003221_abnormal_cardiomyocyte_apopto0.64672621
179MP0002089_abnormal_postnatal_growth/wei0.64669926
180MP0005503_abnormal_tendon_morphology0.63551843
181MP0001879_abnormal_lymphatic_vessel0.63410542
182MP0000462_abnormal_digestive_system0.63074109

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.85930381
2Atrophic scars (HP:0001075)4.78429646
3Type I transferrin isoform profile (HP:0003642)4.39482498
4Recurrent abscess formation (HP:0002722)4.19608660
5Reduced antithrombin III activity (HP:0001976)4.10356531
6Vacuolated lymphocytes (HP:0001922)4.00977565
7Protrusio acetabuli (HP:0003179)3.58867086
8Abnormal protein glycosylation (HP:0012346)3.46608862
9Abnormal glycosylation (HP:0012345)3.46608862
10Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.46608862
11Abnormal protein N-linked glycosylation (HP:0012347)3.46608862
12Recurrent bacterial skin infections (HP:0005406)3.38442497
13Abnormality of nail color (HP:0100643)3.37869540
14Hypothermia (HP:0002045)3.24644425
15Milia (HP:0001056)3.23170419
16Autoimmune thrombocytopenia (HP:0001973)3.22468849
17Onycholysis (HP:0001806)3.17156286
18Flat acetabular roof (HP:0003180)3.08776361
19Aortic dissection (HP:0002647)3.02790885
20Right ventricular cardiomyopathy (HP:0011663)3.01891657
21Eczematoid dermatitis (HP:0000976)3.00676467
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.99334524
23Osteolytic defects of the hand bones (HP:0009699)2.99334524
24Fragile skin (HP:0001030)2.98324039
25Thin bony cortex (HP:0002753)2.90706851
26Plantar hyperkeratosis (HP:0007556)2.84572932
27Thick nail (HP:0001805)2.84033940
28Cheilitis (HP:0100825)2.83816122
29Alopecia of scalp (HP:0002293)2.81602285
30Fragile nails (HP:0001808)2.73463104
31Follicular hyperkeratosis (HP:0007502)2.71130875
32Arterial tortuosity (HP:0005116)2.69991408
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69928441
34Obstructive lung disease (HP:0006536)2.65785176
35Chronic obstructive pulmonary disease (HP:0006510)2.65785176
36Retrobulbar optic neuritis (HP:0100654)2.63764957
37Optic neuritis (HP:0100653)2.63764957
38Gingivitis (HP:0000230)2.62497794
39Myositis (HP:0100614)2.59401797
40Mitral stenosis (HP:0001718)2.57972613
41Vertebral compression fractures (HP:0002953)2.56703150
42Vascular tortuosity (HP:0004948)2.55219889
43Hypoplasia of the fovea (HP:0007750)2.53424107
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.53424107
45Natal tooth (HP:0000695)2.51933545
46Cervical subluxation (HP:0003308)2.51857267
47Syringomyelia (HP:0003396)2.51803827
48Spinal cord lesions (HP:0100561)2.51803827
49Congenital sensorineural hearing impairment (HP:0008527)2.50660800
50Abnormality of macrophages (HP:0004311)2.50084571
51Tetraparesis (HP:0002273)2.49833971
52Wormian bones (HP:0002645)2.49294438
53Recurrent pneumonia (HP:0006532)2.46270378
54Increased IgM level (HP:0003496)2.46217951
55Chromsome breakage (HP:0040012)2.44698664
56Abnormality of carpal bone ossification (HP:0006257)2.40201249
57Ankyloglossia (HP:0010296)2.39265682
58Orchitis (HP:0100796)2.38514126
59Short nail (HP:0001799)2.37730885
60Spondylolisthesis (HP:0003302)2.36458340
61Prostate neoplasm (HP:0100787)2.35382954
62Recurrent fungal infections (HP:0002841)2.35280880
63Mediastinal lymphadenopathy (HP:0100721)2.33108834
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.32871613
65Meningitis (HP:0001287)2.32495582
66Cardiovascular calcification (HP:0011915)2.28899666
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28621526
68Osteomalacia (HP:0002749)2.25848154
69Anhidrosis (HP:0000970)2.23458643
70Eosinophilia (HP:0001880)2.22173862
71Abnormality of oral frenula (HP:0000190)2.21409739
72True hermaphroditism (HP:0010459)2.21184302
73Abnormality of the acetabulum (HP:0003170)2.20979793
74Blue sclerae (HP:0000592)2.20850811
75Aortic aneurysm (HP:0004942)2.18982371
76Mitral valve prolapse (HP:0001634)2.17640271
77Petechiae (HP:0000967)2.16142263
78Conjugated hyperbilirubinemia (HP:0002908)2.14873160
79Chronic mucocutaneous candidiasis (HP:0002728)2.14804936
80Recurrent cutaneous fungal infections (HP:0011370)2.14804936
81Abnormal foot bone ossification (HP:0010675)2.14640821
82Abnormality of eosinophils (HP:0001879)2.14164631
83Recurrent skin infections (HP:0001581)2.13547290
84Termporal pattern (HP:0011008)2.13367532
85Insidious onset (HP:0003587)2.13367532
86Basal ganglia calcification (HP:0002135)2.12684034
87Abnormal ossification of hand bones (HP:0005921)2.12222450
88Thyroiditis (HP:0100646)2.11618194
89Patchy hypopigmentation of hair (HP:0011365)2.11595265
90Ankle contracture (HP:0006466)2.11102425
91Bladder diverticulum (HP:0000015)2.10860428
92Stomatitis (HP:0010280)2.10773510
93Agammaglobulinemia (HP:0004432)2.10695517
94Palmoplantar hyperkeratosis (HP:0000972)2.09693659
95Chronic diarrhea (HP:0002028)2.08838005
96White forelock (HP:0002211)2.07135060
97Soft skin (HP:0000977)2.06329859
98Abnormality of dental color (HP:0011073)2.06106477
99Granulocytopenia (HP:0001913)2.05774806
100Malnutrition (HP:0004395)2.05720390
101Palmar hyperkeratosis (HP:0010765)2.04885062
102Nail dystrophy (HP:0008404)2.03262920
103Ulnar bowing (HP:0003031)2.02999348
104Vasculitis (HP:0002633)2.01936625
105Genu recurvatum (HP:0002816)2.01687314
106Hypoproteinemia (HP:0003075)2.01363283
107Autoimmune hemolytic anemia (HP:0001890)1.99696938
108Elbow flexion contracture (HP:0002987)1.99166145
109Optic nerve hypoplasia (HP:0000609)1.96521393
110Subacute progressive viral hepatitis (HP:0006572)1.96475533
111Abnormality of proline metabolism (HP:0010907)1.95587715
112Hydroxyprolinuria (HP:0003080)1.95587715
113Clubbing of toes (HP:0100760)1.95564742
114Abnormality of the distal phalanges of the toes (HP:0010182)1.94932353
115Dilatation of the ascending aorta (HP:0005111)1.94855764
116Elevated erythrocyte sedimentation rate (HP:0003565)1.94444085
117Severe visual impairment (HP:0001141)1.94342678
118Severe combined immunodeficiency (HP:0004430)1.94101011
119Selective tooth agenesis (HP:0001592)1.94078661
120Hypobetalipoproteinemia (HP:0003563)1.93703582
121Recurrent lower respiratory tract infections (HP:0002783)1.93022044
122Abnormality of the fovea (HP:0000493)1.92949871
123Abnormality of dentin (HP:0010299)1.92176670
124Irregular epiphyses (HP:0010582)1.91229290
125Abnormality of incisor morphology (HP:0011063)1.91186063
126Flat capital femoral epiphysis (HP:0003370)1.90811419
127Abnormality of the prostate (HP:0008775)1.89988645
128Amelogenesis imperfecta (HP:0000705)1.89515828
129Abnormal tarsal ossification (HP:0008369)1.88406406
130Advanced eruption of teeth (HP:0006288)1.88344342
131Vascular calcification (HP:0004934)1.84791318
132Parakeratosis (HP:0001036)1.84117473
133Myocardial infarction (HP:0001658)1.84068494
134Spastic diplegia (HP:0001264)1.83563465
135Pulmonary infiltrates (HP:0002113)1.80984877
136Abnormality of B cell number (HP:0010975)1.80553120
137B lymphocytopenia (HP:0010976)1.80553120
138Fat malabsorption (HP:0002630)1.80312518
139Cerebral aneurysm (HP:0004944)1.78453952
140Abnormal rod and cone electroretinograms (HP:0008323)1.77393457
141Pterygium (HP:0001059)1.77023434
142Tibial bowing (HP:0002982)1.76180201
143Thoracolumbar scoliosis (HP:0002944)1.75904610
144Abnormal hand bone ossification (HP:0010660)1.75734998
145Peritonitis (HP:0002586)1.75538139
146Encephalitis (HP:0002383)1.74679922
147Joint laxity (HP:0001388)1.73603115
148Sparse lateral eyebrow (HP:0005338)1.72784361
149Periodontitis (HP:0000704)1.72471304
150Leukocytosis (HP:0001974)1.71853860
151Osteomyelitis (HP:0002754)1.71055652
152Hypergammaglobulinemia (HP:0010702)1.70745142
153Femoral bowing (HP:0002980)1.70681797
154Abnormality of the preputium (HP:0100587)1.70319997
155Asymmetry of the thorax (HP:0001555)1.70261448
156Hypoplasia of dental enamel (HP:0006297)1.69956963
157Sepsis (HP:0100806)1.69403313
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.68656377
159Disproportionate tall stature (HP:0001519)1.68339127
160Bone pain (HP:0002653)1.67103336
161Abnormality of the distal phalanx of the thumb (HP:0009617)1.66893087
162Relative macrocephaly (HP:0004482)1.66770527
163Pustule (HP:0200039)1.66114531
164Exertional dyspnea (HP:0002875)1.66036932
165Aplasia cutis congenita (HP:0001057)1.65870232
166Distal upper limb amyotrophy (HP:0007149)1.65300452
167Upper limb amyotrophy (HP:0009129)1.65300452
168Neonatal short-limb short stature (HP:0008921)1.65296900
169Metaphyseal irregularity (HP:0003025)1.65179474
170Hyperextensible skin (HP:0000974)1.65131649
171Recurrent viral infections (HP:0004429)1.63536541
172Absent frontal sinuses (HP:0002688)1.63363028
173Abnormality of monocarboxylic acid metabolism (HP:0010996)1.62685394
174Increased mean platelet volume (HP:0011877)1.62621227
175Alveolar cell carcinoma (HP:0006519)1.62585364
176Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62564605
177Spinal rigidity (HP:0003306)1.62412913
178Intrahepatic cholestasis (HP:0001406)1.62362062
179Aneurysm (HP:0002617)1.61771740
180Abnormal blistering of the skin (HP:0008066)1.61570910
181Irregular vertebral endplates (HP:0003301)1.61525222
182Poor head control (HP:0002421)1.61300025
183Abnormal delivery (HP:0001787)1.61200317
184Deviation of the thumb (HP:0009603)1.60440988
185Curly hair (HP:0002212)1.59792052
186Cupped ribs (HP:0000887)1.58386187
187Recurrent gram-negative bacterial infections (HP:0005420)1.58315795
188Dry hair (HP:0011359)1.58220312
189Barrel-shaped chest (HP:0001552)1.58132971
190Lip pit (HP:0100267)1.57678883
191Abnormality of male internal genitalia (HP:0000022)1.55697568
192Febrile seizures (HP:0002373)1.55542071
193Meckel diverticulum (HP:0002245)1.54161286
194Abnormal hair whorl (HP:0010721)1.52977224
195Abnormality of the columella (HP:0009929)1.52471075
196Abnormality of the vertebral endplates (HP:0005106)1.51487857
197Symptomatic seizures (HP:0011145)1.51085302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.83778116
2IRAK33.48482982
3IRAK43.47112558
4MAP3K143.12468778
5PDGFRA2.83636374
6CDK122.82556900
7EIF2AK32.54587635
8AKT32.50530641
9RIPK12.47782133
10MET2.43887730
11TNIK2.43735400
12MST42.35321243
13LATS12.26880130
14FRK2.23453831
15YES12.15433722
16TXK2.15134932
17LATS22.15028733
18PRPF4B2.06216840
19CLK11.97831765
20ERBB41.97733510
21PTK21.94089899
22MKNK21.91431396
23BMPR21.89662735
24PAK41.86381410
25SCYL21.85916689
26ERN11.78760820
27SIK31.77215447
28STK161.77202021
29NLK1.73708170
30NUAK11.66288213
31TTN1.64931094
32TEC1.62341884
33PIM21.62208298
34DDR21.61865061
35ZAK1.58606258
36BMPR1B1.58444306
37TRIB31.56247678
38ICK1.53888099
39ADRBK21.49764418
40EIF2AK21.48276608
41MAP3K121.47430422
42ARAF1.45201225
43MAP3K21.41677093
44ERBB31.39876006
45TAOK31.38751682
46INSRR1.37928938
47IKBKB1.36268585
48CDK61.31503612
49MAP3K31.30214337
50TGFBR21.29637770
51IKBKE1.26206863
52IRAK11.26060706
53VRK11.25702632
54PAK21.23152750
55FLT31.22144893
56KSR21.21952763
57MAP3K101.21643814
58GRK71.18694357
59PDGFRB1.18226393
60MKNK11.15217070
61NTRK11.14557861
62EPHB11.14422627
63ACVR1B1.14105452
64STK31.11929002
65RIPK41.11670088
66MAPK151.08333340
67MYLK1.08023956
68TRPM71.07266548
69JAK31.04324083
70EEF2K1.03931320
71PRKG21.03822716
72KIT1.03655959
73FGFR41.02145081
74PDK21.02004271
75MTOR1.01207205
76TTK1.00921112
77NME21.00630650
78CAMK1D1.00482980
79NME10.98293533
80CAMK1G0.98030714
81EPHB20.97950959
82PBK0.95743371
83TBK10.94685670
84BRD40.93955906
85PIM10.91027963
86SIK10.90956921
87TAOK20.90197681
88CHUK0.89906780
89IRAK20.89726597
90PKN20.89365138
91BLK0.88046504
92CDK80.86119991
93SRPK10.86001044
94MAP3K80.83443729
95NEK60.82933640
96MUSK0.82545779
97GRK10.82237648
98STK240.81951633
99BTK0.80881988
100LYN0.79339159
101CDK30.79168748
102SYK0.79110424
103EPHA30.78568783
104CSK0.77248322
105MOS0.75566123
106SMG10.74930098
107MAP2K30.74019800
108MELK0.73588252
109FER0.73042769
110FES0.71624434
111MAP2K70.71541997
112SGK20.71242400
113BMX0.69241540
114RAF10.68101470
115MAP3K60.67117438
116CDC42BPA0.66899373
117MAP4K10.66876884
118ZAP700.66534938
119MAPK130.66110491
120BRSK20.65418177
121KSR10.64609733
122STK380.62189898
123ABL20.61675896
124HIPK20.61106874
125NEK90.60780727
126TSSK60.60641966
127MST1R0.60082127
128NEK10.57316013
129MATK0.55842536
130JAK10.55510621
131LMTK20.55413860
132PIK3CG0.55174995
133STK100.55015647
134TYK20.54519464
135LCK0.54344693
136MAP3K10.54067829
137PRKCD0.53512472
138PLK40.53080370
139GRK60.52570057
140MAP3K90.52336727
141PIK3CA0.50180871
142WNK10.47999989
143RPS6KB10.47647387
144RET0.46897190
145PRKCE0.42572928
146FGFR10.39763003
147PTK60.39386255
148TNK20.39272916
149RPS6KA20.38892605
150PLK20.38221929
151MAP3K130.37604010
152GSK3A0.37396404
153TESK10.36885047
154ITK0.35988933
155CAMKK20.35916106
156TLK10.35860570
157PRKD20.33938516
158MAP2K20.33663197
159EPHA20.33527137
160PRKCQ0.32627519
161BCR0.32034235
162STK38L0.29954128
163MAPKAPK20.29624498
164BRAF0.27503236
165CDK70.27043780
166ABL10.26478516
167FGFR30.26000690
168PLK30.25125621
169CSNK1A10.24917718
170ADRBK10.24415227
171DYRK1A0.24113847

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.52219452
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.58557822
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.36054882
4Other glycan degradation_Homo sapiens_hsa005112.32066471
5Sphingolipid metabolism_Homo sapiens_hsa006002.17148102
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16809761
7ECM-receptor interaction_Homo sapiens_hsa045122.16091036
8Renin-angiotensin system_Homo sapiens_hsa046142.15600487
9Small cell lung cancer_Homo sapiens_hsa052222.05251218
10Bladder cancer_Homo sapiens_hsa052191.91224570
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.89560929
12Vitamin digestion and absorption_Homo sapiens_hsa049771.81796248
13Fat digestion and absorption_Homo sapiens_hsa049751.70889014
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70162085
15Mineral absorption_Homo sapiens_hsa049781.69526210
16Amoebiasis_Homo sapiens_hsa051461.69344879
17Graft-versus-host disease_Homo sapiens_hsa053321.68965309
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.65911882
19Allograft rejection_Homo sapiens_hsa053301.64452089
20Adherens junction_Homo sapiens_hsa045201.64083303
21Leishmaniasis_Homo sapiens_hsa051401.63626523
22Focal adhesion_Homo sapiens_hsa045101.61505994
23Proteoglycans in cancer_Homo sapiens_hsa052051.54832817
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53874366
25Chronic myeloid leukemia_Homo sapiens_hsa052201.52872229
26Galactose metabolism_Homo sapiens_hsa000521.49980160
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49619072
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48277318
29Protein digestion and absorption_Homo sapiens_hsa049741.46226584
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44942547
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41457120
32Folate biosynthesis_Homo sapiens_hsa007901.41082293
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40859925
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38172075
35Measles_Homo sapiens_hsa051621.37646923
36Hematopoietic cell lineage_Homo sapiens_hsa046401.36012906
37Rheumatoid arthritis_Homo sapiens_hsa053231.35181682
38Pancreatic cancer_Homo sapiens_hsa052121.34580102
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31690832
40MicroRNAs in cancer_Homo sapiens_hsa052061.27518885
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26442336
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24549236
43Arachidonic acid metabolism_Homo sapiens_hsa005901.23825173
44Primary immunodeficiency_Homo sapiens_hsa053401.23019513
45Legionellosis_Homo sapiens_hsa051341.20968966
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.19171625
47Asthma_Homo sapiens_hsa053101.19134522
48Fanconi anemia pathway_Homo sapiens_hsa034601.17987663
49Homologous recombination_Homo sapiens_hsa034401.17739958
50Type I diabetes mellitus_Homo sapiens_hsa049401.15639193
51Autoimmune thyroid disease_Homo sapiens_hsa053201.15284257
52N-Glycan biosynthesis_Homo sapiens_hsa005101.14460616
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11762928
54Influenza A_Homo sapiens_hsa051641.09919664
55Fructose and mannose metabolism_Homo sapiens_hsa000511.09150625
56Pertussis_Homo sapiens_hsa051331.01262213
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.01079881
58Vibrio cholerae infection_Homo sapiens_hsa051101.00958133
59Phagosome_Homo sapiens_hsa041451.00769617
60TGF-beta signaling pathway_Homo sapiens_hsa043501.00315054
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00237959
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.99416452
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98062979
64Tuberculosis_Homo sapiens_hsa051520.97452283
65Starch and sucrose metabolism_Homo sapiens_hsa005000.97199811
66Herpes simplex infection_Homo sapiens_hsa051680.96670497
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95277950
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94332740
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93992703
70RNA polymerase_Homo sapiens_hsa030200.92532794
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91586987
72Renal cell carcinoma_Homo sapiens_hsa052110.90843625
73Sulfur metabolism_Homo sapiens_hsa009200.89750535
74Complement and coagulation cascades_Homo sapiens_hsa046100.88743784
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87495287
76Prion diseases_Homo sapiens_hsa050200.87092508
77Non-small cell lung cancer_Homo sapiens_hsa052230.86083329
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85969249
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.85571192
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85197451
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84441907
82Lysosome_Homo sapiens_hsa041420.84336869
83Pancreatic secretion_Homo sapiens_hsa049720.84263080
84Endometrial cancer_Homo sapiens_hsa052130.80857176
85Base excision repair_Homo sapiens_hsa034100.80727171
86Osteoclast differentiation_Homo sapiens_hsa043800.80601618
87Acute myeloid leukemia_Homo sapiens_hsa052210.79300366
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79111919
89ErbB signaling pathway_Homo sapiens_hsa040120.77721649
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.77601969
91TNF signaling pathway_Homo sapiens_hsa046680.76135987
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75652377
93Fatty acid biosynthesis_Homo sapiens_hsa000610.75565823
94Salmonella infection_Homo sapiens_hsa051320.74688854
95Malaria_Homo sapiens_hsa051440.74412191
96Basal transcription factors_Homo sapiens_hsa030220.73533166
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73517821
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.73200903
99African trypanosomiasis_Homo sapiens_hsa051430.71348401
100Arginine biosynthesis_Homo sapiens_hsa002200.71246975
101Viral carcinogenesis_Homo sapiens_hsa052030.70663409
102Pathways in cancer_Homo sapiens_hsa052000.69928311
103PPAR signaling pathway_Homo sapiens_hsa033200.69926758
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69434010
105Ether lipid metabolism_Homo sapiens_hsa005650.68910666
106Apoptosis_Homo sapiens_hsa042100.68712702
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68612947
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68578953
109Inositol phosphate metabolism_Homo sapiens_hsa005620.68569297
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66752213
111Melanoma_Homo sapiens_hsa052180.66416013
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66023164
113Caffeine metabolism_Homo sapiens_hsa002320.64815527
114Prolactin signaling pathway_Homo sapiens_hsa049170.64308484
115Glioma_Homo sapiens_hsa052140.63883706
116Hepatitis B_Homo sapiens_hsa051610.62761962
117Cell cycle_Homo sapiens_hsa041100.60332137
118Hippo signaling pathway_Homo sapiens_hsa043900.58758178
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58751867
120Insulin resistance_Homo sapiens_hsa049310.58604295
121Collecting duct acid secretion_Homo sapiens_hsa049660.58253520
122Antigen processing and presentation_Homo sapiens_hsa046120.58153537
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57616993
124Pyrimidine metabolism_Homo sapiens_hsa002400.57411364
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56587379
126Phototransduction_Homo sapiens_hsa047440.54855737
127Hepatitis C_Homo sapiens_hsa051600.54691768
128Proteasome_Homo sapiens_hsa030500.54686817
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53847126
130FoxO signaling pathway_Homo sapiens_hsa040680.53845305
131Chemokine signaling pathway_Homo sapiens_hsa040620.53552710
132HIF-1 signaling pathway_Homo sapiens_hsa040660.53314870
133Toxoplasmosis_Homo sapiens_hsa051450.53175013
134Oxidative phosphorylation_Homo sapiens_hsa001900.52864623
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52705698
136Purine metabolism_Homo sapiens_hsa002300.51996380
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.51773376
138VEGF signaling pathway_Homo sapiens_hsa043700.51536212
139Pentose phosphate pathway_Homo sapiens_hsa000300.49318994
140Tight junction_Homo sapiens_hsa045300.48962262
141Regulation of autophagy_Homo sapiens_hsa041400.48603135
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48133570
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.46622277
144DNA replication_Homo sapiens_hsa030300.46112243
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.46024995
146p53 signaling pathway_Homo sapiens_hsa041150.45956524
147Bile secretion_Homo sapiens_hsa049760.44605772
148Colorectal cancer_Homo sapiens_hsa052100.44529943
149Insulin signaling pathway_Homo sapiens_hsa049100.44131971
150Shigellosis_Homo sapiens_hsa051310.43009769
151B cell receptor signaling pathway_Homo sapiens_hsa046620.40504701
152Steroid biosynthesis_Homo sapiens_hsa001000.38982183
153Prostate cancer_Homo sapiens_hsa052150.38463981
154Epstein-Barr virus infection_Homo sapiens_hsa051690.38268438
155Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37487321
156Mismatch repair_Homo sapiens_hsa034300.35451535
157Non-homologous end-joining_Homo sapiens_hsa034500.35244154
158Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34646789
159Thyroid cancer_Homo sapiens_hsa052160.32859437
160Nucleotide excision repair_Homo sapiens_hsa034200.31970773

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