ENTPD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)8.60218612
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.38273254
3L-phenylalanine catabolic process (GO:0006559)7.38273254
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.30870825
5regulation of guanylate cyclase activity (GO:0031282)7.27605811
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.07940620
7L-phenylalanine metabolic process (GO:0006558)7.07940620
8aromatic amino acid family catabolic process (GO:0009074)6.64713927
9NADH metabolic process (GO:0006734)6.53935911
10epoxygenase P450 pathway (GO:0019373)6.47809958
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.43752677
12intestinal absorption (GO:0050892)6.41076750
13indole-containing compound catabolic process (GO:0042436)6.07057652
14indolalkylamine catabolic process (GO:0046218)6.07057652
15tryptophan catabolic process (GO:0006569)6.07057652
16kynurenine metabolic process (GO:0070189)5.93831336
17bile acid biosynthetic process (GO:0006699)5.76600005
18tryptophan metabolic process (GO:0006568)5.70300201
19fat-soluble vitamin biosynthetic process (GO:0042362)5.67955857
20glyoxylate metabolic process (GO:0046487)5.60301005
21urea cycle (GO:0000050)5.58433441
22urea metabolic process (GO:0019627)5.58433441
23high-density lipoprotein particle remodeling (GO:0034375)5.54148880
24alpha-linolenic acid metabolic process (GO:0036109)5.46568517
25sulfur amino acid catabolic process (GO:0000098)5.37969224
26negative regulation of fibrinolysis (GO:0051918)5.33146518
27positive regulation of guanylate cyclase activity (GO:0031284)5.30970673
28cysteine metabolic process (GO:0006534)5.27951128
29regulation of fibrinolysis (GO:0051917)5.16907870
30protein carboxylation (GO:0018214)5.15699844
31peptidyl-glutamic acid carboxylation (GO:0017187)5.15699844
32regulation of protein activation cascade (GO:2000257)5.13484582
33nitrogen cycle metabolic process (GO:0071941)5.12617869
34complement activation, alternative pathway (GO:0006957)5.11723897
35bile acid metabolic process (GO:0008206)5.02700916
36fructose metabolic process (GO:0006000)4.99522116
37regulation of cholesterol esterification (GO:0010872)4.98247499
38regulation of triglyceride catabolic process (GO:0010896)4.95733018
39serine family amino acid catabolic process (GO:0009071)4.94464277
40regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.91781442
41endocrine process (GO:0050886)4.91781442
42regulation of systemic arterial blood pressure by hormone (GO:0001990)4.91781442
43lipoprotein transport (GO:0042953)4.89925571
44reverse cholesterol transport (GO:0043691)4.86659011
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84131467
46aromatic amino acid family metabolic process (GO:0009072)4.82924611
47renal system process involved in regulation of blood volume (GO:0001977)4.82522533
48homocysteine metabolic process (GO:0050667)4.81456661
49regulation of complement activation (GO:0030449)4.77983689
50negative regulation of sterol transport (GO:0032372)4.76582893
51negative regulation of cholesterol transport (GO:0032375)4.76582893
52hormone catabolic process (GO:0042447)4.75726800
53plasma lipoprotein particle remodeling (GO:0034369)4.75349604
54protein-lipid complex remodeling (GO:0034368)4.75349604
55macromolecular complex remodeling (GO:0034367)4.75349604
56phospholipid efflux (GO:0033700)4.72181143
57drug metabolic process (GO:0017144)4.71977988
58acylglycerol homeostasis (GO:0055090)4.67389969
59triglyceride homeostasis (GO:0070328)4.67389969
60bile acid and bile salt transport (GO:0015721)4.63247939
61diacylglycerol metabolic process (GO:0046339)4.61350806
62tyrosine metabolic process (GO:0006570)4.60463405
63lysine metabolic process (GO:0006553)4.50939442
64lysine catabolic process (GO:0006554)4.50939442
65amino-acid betaine metabolic process (GO:0006577)4.50248066
66alpha-amino acid catabolic process (GO:1901606)4.49412811
67regulation of systemic arterial blood pressure (GO:0003073)4.47422847
68cellular ketone body metabolic process (GO:0046950)4.37523143
69regulation of cGMP biosynthetic process (GO:0030826)4.37340190
70receptor guanylyl cyclase signaling pathway (GO:0007168)4.34305787
71cholesterol efflux (GO:0033344)4.33127482
72cellular glucuronidation (GO:0052695)4.30667041
73indolalkylamine metabolic process (GO:0006586)4.29206170
74plasma lipoprotein particle clearance (GO:0034381)4.29077092
75coenzyme catabolic process (GO:0009109)4.27344591
76maintenance of gastrointestinal epithelium (GO:0030277)4.27019901
77imidazole-containing compound metabolic process (GO:0052803)4.23960002
78drug catabolic process (GO:0042737)4.22636105
79regulation of cellular extravasation (GO:0002691)4.22286139
80glycine metabolic process (GO:0006544)4.21243655
81cellular biogenic amine catabolic process (GO:0042402)4.20070784
82amine catabolic process (GO:0009310)4.20070784
83glutamate metabolic process (GO:0006536)4.18646666
84cellular amino acid catabolic process (GO:0009063)4.15621530
85plasma lipoprotein particle assembly (GO:0034377)4.14989873
86positive regulation of pseudopodium assembly (GO:0031274)4.12779091
87positive regulation of respiratory burst (GO:0060267)4.09055271
88benzene-containing compound metabolic process (GO:0042537)4.08054831
89regulation of bile acid biosynthetic process (GO:0070857)4.06483653
90intestinal cholesterol absorption (GO:0030299)4.05923658
91antibacterial humoral response (GO:0019731)4.03986791
92serine family amino acid metabolic process (GO:0009069)4.03210697
93ethanol oxidation (GO:0006069)4.02820375
94vitamin transmembrane transport (GO:0035461)4.00794803
95cellular modified amino acid catabolic process (GO:0042219)4.00417125
96positive regulation of triglyceride lipase activity (GO:0061365)3.97395280
97positive regulation of lipoprotein lipase activity (GO:0051006)3.97395280
98antimicrobial humoral response (GO:0019730)3.95572446
99arginine metabolic process (GO:0006525)3.93643161
100regulation of cholesterol homeostasis (GO:2000188)3.91831231
101calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.91173265
102very-low-density lipoprotein particle assembly (GO:0034379)3.90405784
103serine family amino acid biosynthetic process (GO:0009070)3.90232392
104cholesterol homeostasis (GO:0042632)3.87937574
105low-density lipoprotein particle remodeling (GO:0034374)3.86357725
106dicarboxylic acid biosynthetic process (GO:0043650)3.84865418
107uronic acid metabolic process (GO:0006063)3.82514342
108glucuronate metabolic process (GO:0019585)3.82514342
109fibrinolysis (GO:0042730)3.81983853
110sterol homeostasis (GO:0055092)3.81871816
111aldehyde catabolic process (GO:0046185)3.80377532
112GDP-mannose metabolic process (GO:0019673)3.78914377
113phospholipid homeostasis (GO:0055091)3.78480861
114ketone body metabolic process (GO:1902224)3.78349377
115flavonoid metabolic process (GO:0009812)3.76540371
116regulation of vitamin metabolic process (GO:0030656)3.76169068
117positive regulation of lipid catabolic process (GO:0050996)3.75193075
118protein-lipid complex assembly (GO:0065005)3.73110931
119regulation of pseudopodium assembly (GO:0031272)3.67322257
120plasma lipoprotein particle organization (GO:0071827)3.66306812
121organic acid catabolic process (GO:0016054)3.65232923
122carboxylic acid catabolic process (GO:0046395)3.65232923
123virion attachment to host cell (GO:0019062)3.65000902
124adhesion of symbiont to host cell (GO:0044650)3.65000902
125peptide catabolic process (GO:0043171)3.64739118
126cofactor catabolic process (GO:0051187)3.64611448
127blood coagulation, intrinsic pathway (GO:0007597)3.64477183
128short-chain fatty acid metabolic process (GO:0046459)3.63726796
129complement activation, classical pathway (GO:0006958)3.63487314
130negative regulation of lipase activity (GO:0060192)3.63006022
131exogenous drug catabolic process (GO:0042738)3.62996887
132renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.60293298
133alkaloid metabolic process (GO:0009820)3.59466231
134acetyl-CoA metabolic process (GO:0006084)3.58537000
135protein activation cascade (GO:0072376)3.58240826
136regulation of cGMP metabolic process (GO:0030823)3.58146291
137complement activation (GO:0006956)3.57942228
138lipoprotein metabolic process (GO:0042157)3.57916219
139glycosphingolipid catabolic process (GO:0046479)3.56440124
140glutamine family amino acid biosynthetic process (GO:0009084)3.53775192
141glycolipid catabolic process (GO:0019377)3.53516344
142peptide hormone processing (GO:0016486)3.52850348
143digestion (GO:0007586)3.47631968
144vitamin transport (GO:0051180)3.46891825
145glomerular filtration (GO:0003094)3.45241824
146phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.44549328
147sulfate transmembrane transport (GO:1902358)3.43990130
148ethanol metabolic process (GO:0006067)3.39901658
149positive regulation of Cdc42 GTPase activity (GO:0043089)3.31398625
150sphingomyelin metabolic process (GO:0006684)3.27187999
151regulation of respiratory burst (GO:0060263)3.24544864
152cGMP-mediated signaling (GO:0019934)3.22036046
153drug transport (GO:0015893)3.21469912
154adhesion of symbiont to host (GO:0044406)3.21117440
155digestive system process (GO:0022600)3.20227116
156renal filtration (GO:0097205)3.19076502
157transcytosis (GO:0045056)3.17098230
158proline biosynthetic process (GO:0006561)3.16532426
159oligosaccharide biosynthetic process (GO:0009312)3.15291630
160positive regulation of fatty acid beta-oxidation (GO:0032000)3.12760507
161O-glycan processing (GO:0016266)3.11028775
162proline metabolic process (GO:0006560)3.10438629
163epithelial structure maintenance (GO:0010669)3.09823307
164positive regulation of cGMP biosynthetic process (GO:0030828)3.01048404
165actin filament depolymerization (GO:0030042)2.99908585
166desmosome organization (GO:0002934)2.99589583
167regulation of cholesterol metabolic process (GO:0090181)2.96007486
168purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.95671851
1693-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.95671851
170sphingolipid catabolic process (GO:0030149)2.95096645
171sulfur compound transport (GO:0072348)2.94731716
172sodium ion homeostasis (GO:0055078)2.92929807
173cellular response to nitric oxide (GO:0071732)2.91882124
174glutathione biosynthetic process (GO:0006750)2.91355274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.22534777
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14047779
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.78573234
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.43467213
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.15664877
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.90703266
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74177352
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98005819
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.81124389
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.23155546
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02574832
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7139526
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91592237
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88288317
15TET1_21451524_ChIP-Seq_MESCs_Mouse1.79454448
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69494849
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.63487972
18KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61376711
19* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60905587
20VDR_21846776_ChIP-Seq_THP-1_Human1.60857662
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.60080411
22* RUNX1_27514584_Chip-Seq_MCF-7_Human1.59765847
23SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57858324
24BCL6_27268052_Chip-Seq_Bcells_Human1.53625843
25CLOCK_20551151_ChIP-Seq_293T_Human1.53131129
26CTCF_27219007_Chip-Seq_Bcells_Human1.52806745
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51830305
28HTT_18923047_ChIP-ChIP_STHdh_Human1.51341349
29HNF4A_19822575_ChIP-Seq_HepG2_Human1.47905388
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43081594
31SA1_27219007_Chip-Seq_Bcells_Human1.42364919
32CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41863771
33P68_20966046_ChIP-Seq_HELA_Human1.41388162
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40228065
35GATA1_22025678_ChIP-Seq_K562_Human1.37830653
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36367005
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34943939
38P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34891363
39KLF5_25053715_ChIP-Seq_YYC3_Human1.32598569
40* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.31692202
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30667456
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.29945879
43SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29147320
44* CREB1_26743006_Chip-Seq_LNCaP_Human1.28559731
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26666138
46E2F1_20622854_ChIP-Seq_HELA_Human1.24746073
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20178459
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20104662
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19768021
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19694759
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.18785852
52SMC4_20622854_ChIP-Seq_HELA_Human1.18690119
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16185105
54PHF8_20622854_ChIP-Seq_HELA_Human1.15919117
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15863829
56VDR_24763502_ChIP-Seq_THP-1_Human1.15326670
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14854753
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.14666752
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13279889
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13165368
61GATA4_25053715_ChIP-Seq_YYC3_Human1.10174733
62* TP63_22573176_ChIP-Seq_HFKS_Human1.08307248
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07207726
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06824374
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06744845
66CTCF_20526341_ChIP-Seq_ESCs_Human1.04111562
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03320157
68CDX2_20551321_ChIP-Seq_CACO-2_Human1.02051510
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01874852
70DROSHA_22980978_ChIP-Seq_HELA_Human1.00594160
71* ETS1_21867929_ChIP-Seq_TH2_Mouse0.99988301
72TCF7_22412390_ChIP-Seq_EML_Mouse0.99560075
73ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98394335
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96456028
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95282654
76SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95238419
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92941929
78RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87925458
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83549833
80KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83456692
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82451437
82IRF8_22096565_ChIP-ChIP_GC-B_Human0.82351348
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79574943
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77721871
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77547265
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76972470
87* RARA_24833708_ChIP-Seq_LIVER_Mouse0.76155033
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75706972
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74583240
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74105984
91ZNF263_19887448_ChIP-Seq_K562_Human0.73305731
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72824518
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71711347
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70700904
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70615801
96GATA6_25053715_ChIP-Seq_YYC3_Human0.68148179
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67750422
98* ESR2_21235772_ChIP-Seq_MCF-7_Human0.67685000
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66914242
100* RARB_24833708_ChIP-Seq_LIVER_Mouse0.62894542
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61590493
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61590493
103EGR1_19032775_ChIP-ChIP_M12_Human0.61352782
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61287524
105LXR_22292898_ChIP-Seq_THP-1_Human0.60765895
106FOXA1_25552417_ChIP-Seq_VCAP_Human0.60069704
107CEBPB_22108803_ChIP-Seq_LS180_Human0.59969534
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58987216
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58856335
110SOX2_20726797_ChIP-Seq_SW620_Human0.58782453
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.58298881
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.57422087
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.57072206
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56875316
115MYC_19915707_ChIP-ChIP_AK7_Human0.56613970
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.54324920
117FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53584028
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52846148
119AR_20517297_ChIP-Seq_VCAP_Human0.52248357
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52033006
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.50110129
122STAT1_17558387_ChIP-Seq_HELA_Human0.49925827
123GATA2_19941826_ChIP-Seq_K562_Human0.49067561
124P53_21459846_ChIP-Seq_SAOS-2_Human0.48937419
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48698100
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47279401
127TAF2_19829295_ChIP-Seq_ESCs_Human0.47254727
128TP63_17297297_ChIP-ChIP_HaCaT_Human0.46492494
129CBP_21632823_ChIP-Seq_H3396_Human0.44891476
130GATA1_19941826_ChIP-Seq_K562_Human0.44748914
131BCAT_22108803_ChIP-Seq_LS180_Human0.43922377
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.43704417
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.42106078
134PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.41874173
135RACK7_27058665_Chip-Seq_MCF-7_Human0.41390219
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39957631
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.39473527
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.39006493
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.38960894
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.38750716
141CDX2_22108803_ChIP-Seq_LS180_Human0.38743693
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.38680981
143MYC_27129775_Chip-Seq_CORNEA_Mouse0.38319483
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.37490092
145BCOR_27268052_Chip-Seq_Bcells_Human0.36835020
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36694495
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.36667227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17364039
2MP0005360_urolithiasis7.87194883
3MP0005085_abnormal_gallbladder_physiolo6.42870950
4MP0005365_abnormal_bile_salt6.01864609
5MP0008875_abnormal_xenobiotic_pharmacok5.10422262
6MP0003806_abnormal_nucleotide_metabolis4.14445982
7MP0003252_abnormal_bile_duct4.03619944
8MP0010329_abnormal_lipoprotein_level3.58764584
9MP0003183_abnormal_peptide_metabolism3.44205128
10MP0009840_abnormal_foam_cell3.34816044
11MP0009379_abnormal_foot_pigmentation3.26208471
12MP0001666_abnormal_nutrient_absorption3.04026999
13MP0005083_abnormal_biliary_tract2.91053761
14MP0010155_abnormal_intestine_physiology2.71507637
15MP0005332_abnormal_amino_acid2.69823096
16MP0003195_calcinosis2.68371019
17MP0004147_increased_porphyrin_level2.64221729
18MP0005409_darkened_coat_color2.47971173
19MP0001664_abnormal_digestion2.30323823
20MP0003866_abnormal_defecation2.27926172
21MP0003191_abnormal_cellular_cholesterol2.25376619
22MP0004019_abnormal_vitamin_homeostasis2.21585205
23MP0000609_abnormal_liver_physiology2.12316587
24MP0002118_abnormal_lipid_homeostasis2.07429108
25MP0000490_abnormal_crypts_of1.97317275
26MP0010352_gastrointestinal_tract_polyps1.87364140
27MP0003868_abnormal_feces_composition1.87251454
28MP0002138_abnormal_hepatobiliary_system1.86875893
29MP0005319_abnormal_enzyme/_coenzyme1.77789034
30MP0000477_abnormal_intestine_morphology1.72378884
31MP0000678_abnormal_parathyroid_gland1.69406944
32MP0001873_stomach_inflammation1.60296581
33MP0001764_abnormal_homeostasis1.59538499
34MP0009697_abnormal_copulation1.57998148
35MP0005451_abnormal_body_composition1.52111297
36MP0005584_abnormal_enzyme/coenzyme_acti1.51143216
37MP0004858_abnormal_nervous_system1.50547585
38MP0001188_hyperpigmentation1.42553993
39MP0002098_abnormal_vibrissa_morphology1.40610509
40MP0001663_abnormal_digestive_system1.40491689
41MP0003879_abnormal_hair_cell1.33579525
42MP0000462_abnormal_digestive_system1.31891257
43MP0009643_abnormal_urine_homeostasis1.30415055
44MP0003705_abnormal_hypodermis_morpholog1.24369392
45MP0003011_delayed_dark_adaptation1.23665750
46MP0005381_digestive/alimentary_phenotyp1.22270813
47MP0003656_abnormal_erythrocyte_physiolo1.16326072
48MP0000598_abnormal_liver_morphology1.12169470
49MP0003186_abnormal_redox_activity1.11472032
50MP0005501_abnormal_skin_physiology1.10484750
51MP0002254_reproductive_system_inflammat1.06483703
52MP0000537_abnormal_urethra_morphology1.06081076
53MP0005647_abnormal_sex_gland1.05061043
54MP0000604_amyloidosis1.01250070
55MP0009764_decreased_sensitivity_to1.00653071
56MP0005636_abnormal_mineral_homeostasis0.99699806
57MP0005058_abnormal_lysosome_morphology0.97568558
58MP0000566_synostosis0.96719634
59MP0009763_increased_sensitivity_to0.94256421
60MP0005084_abnormal_gallbladder_morpholo0.90257565
61MP0009642_abnormal_blood_homeostasis0.87119069
62MP0008469_abnormal_protein_level0.86228932
63MP0010368_abnormal_lymphatic_system0.85154282
64MP0002876_abnormal_thyroid_physiology0.83295864
65MP0005408_hypopigmentation0.81496199
66MP0005376_homeostasis/metabolism_phenot0.77464844
67MP0006036_abnormal_mitochondrial_physio0.75073539
68MP0010234_abnormal_vibrissa_follicle0.74207359
69MP0009765_abnormal_xenobiotic_induced0.73941299
70MP0002078_abnormal_glucose_homeostasis0.73872423
71MP0002822_catalepsy0.73131608
72MP0009053_abnormal_anal_canal0.72075212
73MP0005174_abnormal_tail_pigmentation0.71244525
74MP0002971_abnormal_brown_adipose0.70631556
75MP0005220_abnormal_exocrine_pancreas0.67587891
76MP0005266_abnormal_metabolism0.67099121
77MP0002166_altered_tumor_susceptibility0.66581134
78MP0003303_peritoneal_inflammation0.65919356
79MP0005334_abnormal_fat_pad0.65805988
80MP0002896_abnormal_bone_mineralization0.63572123
81MP0005448_abnormal_energy_balance0.63203555
82MP0005670_abnormal_white_adipose0.63006575
83MP0004270_analgesia0.62861956
84MP0001756_abnormal_urination0.62019542
85MP0004947_skin_inflammation0.60958074
86MP0004264_abnormal_extraembryonic_tissu0.60336007
87MP0010678_abnormal_skin_adnexa0.59990681
88MP0005535_abnormal_body_temperature0.59761502
89MP0000465_gastrointestinal_hemorrhage0.58735384
90MP0001849_ear_inflammation0.58585482
91MP0004130_abnormal_muscle_cell0.58386711
92MP0001216_abnormal_epidermal_layer0.58149717
93MP0003690_abnormal_glial_cell0.57197182
94MP0003329_amyloid_beta_deposits0.55516984
95MP0009785_altered_susceptibility_to0.54872946
96MP0002249_abnormal_larynx_morphology0.54722307
97MP0009333_abnormal_splenocyte_physiolog0.53703884
98MP0001661_extended_life_span0.53524011
99MP0005025_abnormal_response_to0.52904445
100MP0006035_abnormal_mitochondrial_morpho0.52723964
101MP0005464_abnormal_platelet_physiology0.51653635
102MP0000467_abnormal_esophagus_morphology0.51627761
103MP0002136_abnormal_kidney_physiology0.51511160
104MP0000639_abnormal_adrenal_gland0.51156203
105MP0000377_abnormal_hair_follicle0.50239760
106MP0003718_maternal_effect0.48619440
107MP0005310_abnormal_salivary_gland0.48616506
108MP0003638_abnormal_response/metabolism_0.48232128
109MP0005166_decreased_susceptibility_to0.45910850
110MP0005395_other_phenotype0.45586395
111MP0000470_abnormal_stomach_morphology0.44904790
112MP0000013_abnormal_adipose_tissue0.44492374
113MP0001501_abnormal_sleep_pattern0.44353529
114MP0002796_impaired_skin_barrier0.44299085
115MP0008872_abnormal_physiological_respon0.43867132
116MP0008873_increased_physiological_sensi0.43731756
117MP0008874_decreased_physiological_sensi0.41728693
118MP0003724_increased_susceptibility_to0.41632883
119MP0003953_abnormal_hormone_level0.41473646
120MP0003436_decreased_susceptibility_to0.39857704
121MP0009384_cardiac_valve_regurgitation0.39856445
122MP0002928_abnormal_bile_duct0.39643273
123MP0005248_abnormal_Harderian_gland0.39388045
124MP0004782_abnormal_surfactant_physiolog0.39345362
125MP0003075_altered_response_to0.38625807
126MP0000579_abnormal_nail_morphology0.35872012
127MP0005666_abnormal_adipose_tissue0.34889303
128MP0005167_abnormal_blood-brain_barrier0.33794509
129MP0000230_abnormal_systemic_arterial0.33095099
130MP0006082_CNS_inflammation0.32926468
131MP0009115_abnormal_fat_cell0.32919050
132MP0004043_abnormal_pH_regulation0.32068041
133MP0002132_abnormal_respiratory_system0.32053449
134MP0000249_abnormal_blood_vessel0.31583463
135MP0002837_dystrophic_cardiac_calcinosis0.30868967
136MP0000538_abnormal_urinary_bladder0.30539158
137MP0001845_abnormal_inflammatory_respons0.30336947
138MP0009672_abnormal_birth_weight0.28968071
139MP0001881_abnormal_mammary_gland0.28838590
140MP0001765_abnormal_ion_homeostasis0.28604430
141MP0001243_abnormal_dermal_layer0.27565297
142MP0003453_abnormal_keratinocyte_physiol0.27335667
143MP0004381_abnormal_hair_follicle0.27142526

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.31741325
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.22903204
3Deep venous thrombosis (HP:0002625)7.12016549
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64874888
5Hypobetalipoproteinemia (HP:0003563)6.55348637
6Prolonged partial thromboplastin time (HP:0003645)6.36136796
7Xanthomatosis (HP:0000991)6.23472046
8Hyperlipoproteinemia (HP:0010980)5.36161203
9Hyperactive renin-angiotensin system (HP:0000841)5.18762502
10Complement deficiency (HP:0004431)5.14399997
11Decreased circulating renin level (HP:0003351)4.83462970
12Hypolipoproteinemia (HP:0010981)4.81040581
13Hyperammonemia (HP:0001987)4.56889941
14Joint hemorrhage (HP:0005261)4.55053316
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.46920940
16Epidermoid cyst (HP:0200040)4.46001819
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.36632222
18Widely patent fontanelles and sutures (HP:0004492)4.35033456
19Ileus (HP:0002595)4.34952427
20Abnormality of the common coagulation pathway (HP:0010990)4.32619954
21Hyperglycinemia (HP:0002154)4.31637106
22Fat malabsorption (HP:0002630)4.28432219
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.22906085
24Ketosis (HP:0001946)4.12966857
25Abnormality of the vitamin B12 metabolism (HP:0004341)4.12691223
26Thin bony cortex (HP:0002753)4.12623021
27Conjugated hyperbilirubinemia (HP:0002908)4.10853436
28Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10369923
29Hypoalphalipoproteinemia (HP:0003233)4.07912044
30Metabolic alkalosis (HP:0200114)4.07150432
31Abnormality of renin-angiotensin system (HP:0000847)4.05534880
32Hyperglycinuria (HP:0003108)4.04481113
33Abnormality of methionine metabolism (HP:0010901)4.01708164
34Abnormality of glycine metabolism (HP:0010895)3.95048348
35Abnormality of serine family amino acid metabolism (HP:0010894)3.95048348
36Chronic diarrhea (HP:0002028)3.93634020
37Abnormality of vitamin B metabolism (HP:0004340)3.81241244
38Hypoglycemic coma (HP:0001325)3.81182298
39Abnormality of complement system (HP:0005339)3.75528358
40Abnormality of pyrimidine metabolism (HP:0004353)3.69062880
41Confusion (HP:0001289)3.67524929
42Hypercholesterolemia (HP:0003124)3.66817132
43Abnormality of the intrinsic pathway (HP:0010989)3.63468608
44Abdominal distention (HP:0003270)3.61002243
45Hyperbilirubinemia (HP:0002904)3.35479089
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32242343
47Abnormality of fatty-acid metabolism (HP:0004359)3.28781765
48Wide cranial sutures (HP:0010537)3.26879281
49Flat acetabular roof (HP:0003180)3.21333242
50Spontaneous abortion (HP:0005268)3.15825929
51Steatorrhea (HP:0002570)3.07532679
52Abnormality of nucleobase metabolism (HP:0010932)3.06792261
53Ketoacidosis (HP:0001993)3.01789483
54Delayed CNS myelination (HP:0002188)2.98470023
55Myocardial infarction (HP:0001658)2.95947356
56Abnormality of serum amino acid levels (HP:0003112)2.90592258
57Hepatocellular carcinoma (HP:0001402)2.88498511
58Hypophosphatemia (HP:0002148)2.86003307
59Nausea (HP:0002018)2.84586849
60Acanthocytosis (HP:0001927)2.83199150
61Congenital sensorineural hearing impairment (HP:0008527)2.82683736
62Metabolic acidosis (HP:0001942)2.82634274
63Hypochromic microcytic anemia (HP:0004840)2.80627665
64Pigmentary retinal degeneration (HP:0001146)2.79018067
65Hyperparathyroidism (HP:0000843)2.78416007
66Nephrolithiasis (HP:0000787)2.75936134
67Abnormality of purine metabolism (HP:0004352)2.75656952
68Proximal tubulopathy (HP:0000114)2.75383195
69Abnormality of small intestinal villus morphology (HP:0011472)2.73841581
70Villous atrophy (HP:0011473)2.73841581
71Malnutrition (HP:0004395)2.73037749
72Skin nodule (HP:0200036)2.72748535
73Delayed epiphyseal ossification (HP:0002663)2.71361464
74Vascular calcification (HP:0004934)2.70892370
75Systemic lupus erythematosus (HP:0002725)2.66991830
76Right ventricular cardiomyopathy (HP:0011663)2.66877790
77Abnormal urine phosphate concentration (HP:0012599)2.63755864
78Dicarboxylic aciduria (HP:0003215)2.59762438
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59762438
80Lethargy (HP:0001254)2.56568506
81Increased purine levels (HP:0004368)2.56387661
82Hyperuricemia (HP:0002149)2.56387661
83Pili torti (HP:0003777)2.54077336
84Megaloblastic anemia (HP:0001889)2.50747677
85Enlarged epiphyses (HP:0010580)2.50532941
86Abnormal gallbladder morphology (HP:0012437)2.46693589
87Hypoglycemic seizures (HP:0002173)2.46401372
88Hypotension (HP:0002615)2.44788665
89Gout (HP:0001997)2.42396468
90Cholelithiasis (HP:0001081)2.41390833
91Abnormality of chloride homeostasis (HP:0011422)2.40954200
92Cardiovascular calcification (HP:0011915)2.39686583
93Spastic diplegia (HP:0001264)2.39100223
94Hyperaldosteronism (HP:0000859)2.38243284
95Glomerulonephritis (HP:0000099)2.36751160
96Cholecystitis (HP:0001082)2.34640991
97Abnormal gallbladder physiology (HP:0012438)2.34640991
98Potter facies (HP:0002009)2.34100258
99Facial shape deformation (HP:0011334)2.34100258
100Irritability (HP:0000737)2.33707591
101Hyperphosphaturia (HP:0003109)2.32938766
102Mitral stenosis (HP:0001718)2.32003088
103Amyloidosis (HP:0011034)2.31293695
104Cerebral edema (HP:0002181)2.29173247
105Focal segmental glomerulosclerosis (HP:0000097)2.28311642
106Abnormality of the costochondral junction (HP:0000919)2.28185370
107Late onset (HP:0003584)2.27591426
108Esophageal varix (HP:0002040)2.23058785
109Neonatal onset (HP:0003623)2.22745754
110Renal tubular acidosis (HP:0001947)2.22135891
111Protuberant abdomen (HP:0001538)2.20869908
112Pancreatitis (HP:0001733)2.20790066
113Gingival bleeding (HP:0000225)2.19946453
114Poikilocytosis (HP:0004447)2.19526042
115Sensorimotor neuropathy (HP:0007141)2.17254985
116Hydroxyprolinuria (HP:0003080)2.15723681
117Abnormality of proline metabolism (HP:0010907)2.15723681
118Recurrent gram-negative bacterial infections (HP:0005420)2.14173078
119Abnormal hair laboratory examination (HP:0003328)2.13499700
120Nephritis (HP:0000123)2.12869542
121Hypokalemia (HP:0002900)2.12466797
122Eczematoid dermatitis (HP:0000976)2.12060675
123Abnormal tarsal ossification (HP:0008369)2.11238182
124Growth hormone excess (HP:0000845)2.08915697
125Vomiting (HP:0002013)2.07836918
126Brushfield spots (HP:0001088)2.07774242
127Hyponatremia (HP:0002902)2.07334331
128Menorrhagia (HP:0000132)2.06365717
129Hemorrhage of the eye (HP:0011885)2.05180218
130Cerebral palsy (HP:0100021)2.05169645
131Enlarged kidneys (HP:0000105)2.03773081
132Myopathic facies (HP:0002058)2.03110701
133Abnormal cartilage morphology (HP:0002763)2.03103262
134Thrombophlebitis (HP:0004418)2.02203414
135Abnormality of the gallbladder (HP:0005264)2.01926814
136Hyperinsulinemic hypoglycemia (HP:0000825)2.00683675
137Hyperphosphatemia (HP:0002905)1.99369397
138Rickets (HP:0002748)1.98068659
139Generalized aminoaciduria (HP:0002909)1.97894416
140Opisthotonus (HP:0002179)1.97075904
141Abnormality of alkaline phosphatase activity (HP:0004379)1.94998394
142Posterior subcapsular cataract (HP:0007787)1.94221245
143Alkalosis (HP:0001948)1.93908297
144Renal tubular dysfunction (HP:0000124)1.92544164
145Abnormality of transition element cation homeostasis (HP:0011030)1.92009701
146Abnormality of iron homeostasis (HP:0011031)1.91088204
147Hypophosphatemic rickets (HP:0004912)1.86638903
148Dehydration (HP:0001944)1.86032387
149Abnormality of potassium homeostasis (HP:0011042)1.85194631
150Glomerulosclerosis (HP:0000096)1.84600864
151Abnormality of vitamin metabolism (HP:0100508)1.83706888
152Gastrointestinal dysmotility (HP:0002579)1.82153682
153Glycosuria (HP:0003076)1.81994159
154Abnormality of urine glucose concentration (HP:0011016)1.81994159
155Abnormal enzyme/coenzyme activity (HP:0012379)1.81032134
156Reticulocytosis (HP:0001923)1.80748038
157Elevated hepatic transaminases (HP:0002910)1.79436636
158Multiple lipomas (HP:0001012)1.79231198
159Renal cortical cysts (HP:0000803)1.78838106
160Abnormal albumin level (HP:0012116)1.76732836
161Hypoalbuminemia (HP:0003073)1.76732836
162Bone pain (HP:0002653)1.76384264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.36099984
2ACVR1B5.76416785
3FGFR44.45390853
4ERN14.36730775
5TAOK34.32825631
6SIK14.23339670
7MST1R2.98102735
8ERBB42.85898063
9INSRR2.74002921
10TESK22.42216413
11FRK2.26778543
12PKN22.05063592
13MAP2K42.00060037
14MAPK111.91291878
15PTK61.90169009
16PIK3CG1.66051447
17TYK21.65394981
18FLT31.61193451
19TRIB31.55499852
20LATS11.55026552
21STK391.53276964
22GRK61.51110324
23SMG11.47903664
24TESK11.45179178
25DAPK21.41178424
26MAP3K71.38669410
27ABL21.29108544
28NEK91.24779865
29PRKAA21.24615496
30MAP3K101.22121471
31ERBB21.20756718
32MAP4K11.20415445
33DDR21.19113725
34RIPK11.16231793
35JAK21.15554462
36KDR1.15057795
37FGFR21.09165879
38OXSR11.08553373
39MET1.07999279
40PRPF4B1.04930733
41TBK11.04483392
42MAP3K141.01418686
43TAOK11.00571740
44PDK21.00224551
45MAP3K120.99925416
46MAPK150.99896029
47WNK40.96840325
48EPHB10.92983557
49JAK10.90724156
50MAP2K60.90680918
51RIPK40.90662092
52MATK0.89761661
53MAPK40.88359021
54PRKCZ0.87873511
55MAPKAPK30.87295673
56PAK40.87006475
57MAP2K30.84880244
58CDC42BPA0.83799732
59MAP3K110.82316095
60STK240.81435124
61MAP2K20.81240008
62MAP3K30.79848178
63STK38L0.79453675
64EPHB20.78725491
65MUSK0.78134383
66PTK20.76741849
67MST40.75511184
68CAMK2G0.75222214
69DYRK1B0.74645199
70PINK10.74289094
71PRKACG0.73984593
72CDK60.73642062
73PRKAA10.72167642
74CSK0.70706133
75GRK10.69849573
76IRAK30.69026319
77NME10.66992944
78PIK3CA0.64286650
79MAP3K130.63468635
80EPHA30.63451086
81GSK3A0.62666396
82MAP2K10.59680611
83PRKG20.59111773
84MAPK120.58946166
85TIE10.57738422
86FER0.57478149
87PDPK10.57470527
88ZAP700.57413432
89SGK30.56278172
90ICK0.55605328
91PRKCI0.55598782
92RPS6KA20.55093594
93CAMK1D0.53344424
94PRKCQ0.53092238
95EEF2K0.52989112
96CAMK2D0.51072805
97IKBKE0.49989661
98MAP3K20.48013876
99FGFR30.45794507
100PBK0.45562051
101LMTK20.45169070
102SRC0.44082495
103AKT30.43147853
104MYLK0.42812064
105PRKD20.42229286
106MAPK70.41694476
107TGFBR20.40143859
108PDGFRA0.39652692
109NEK60.37716048
110MAP3K10.37340715
111IRAK10.36747581
112CSNK1G10.36159777
113IGF1R0.36039084
114EPHA40.34749797
115LRRK20.34127170
116CSF1R0.33645361
117RET0.33629671
118RPS6KB20.32441154
119PDK10.32186762
120SGK20.31979580
121MAPKAPK20.31743774
122EPHA20.31176262
123PRKCD0.30866385
124PRKCA0.30781194
125NUAK10.30255242
126BMX0.30027809
127KSR20.29973029
128MAP3K50.29758781
129RPS6KC10.29709368
130RPS6KL10.29709368
131TAOK20.29158858
132CDK40.28399647
133MTOR0.27676952
134CAMK2B0.26685909
135PKN10.26180526
136EGFR0.26002879
137PAK30.24276350
138SGK2230.23659381
139SGK4940.23659381
140PIM20.23031910
141IRAK20.22941926
142FYN0.22763728
143MAP3K80.21867928
144PRKCG0.21862042
145RPS6KA60.21738516
146TNIK0.18229682
147MELK0.17811990

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.38201017
2Nitrogen metabolism_Homo sapiens_hsa009103.47402869
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40827982
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16259092
5Arginine biosynthesis_Homo sapiens_hsa002202.99950960
6Tryptophan metabolism_Homo sapiens_hsa003802.71169493
7Complement and coagulation cascades_Homo sapiens_hsa046102.63727986
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59663081
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59461510
10Fatty acid degradation_Homo sapiens_hsa000712.47693756
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44852651
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33859042
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30058964
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15389625
15Butanoate metabolism_Homo sapiens_hsa006502.13992147
16Peroxisome_Homo sapiens_hsa041462.03757771
17Histidine metabolism_Homo sapiens_hsa003402.01792986
18Chemical carcinogenesis_Homo sapiens_hsa052041.93479046
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.91393418
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91280248
21PPAR signaling pathway_Homo sapiens_hsa033201.89113140
22Propanoate metabolism_Homo sapiens_hsa006401.86128243
23Caffeine metabolism_Homo sapiens_hsa002321.82274819
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.78161865
25Fatty acid metabolism_Homo sapiens_hsa012121.75439353
26Retinol metabolism_Homo sapiens_hsa008301.69344921
27beta-Alanine metabolism_Homo sapiens_hsa004101.68292451
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66743814
29Staphylococcus aureus infection_Homo sapiens_hsa051501.66700883
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64415459
31Bile secretion_Homo sapiens_hsa049761.64301483
32Sulfur metabolism_Homo sapiens_hsa009201.60714836
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58392099
34Selenocompound metabolism_Homo sapiens_hsa004501.56344477
35Fat digestion and absorption_Homo sapiens_hsa049751.51647047
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51210821
37Phenylalanine metabolism_Homo sapiens_hsa003601.50814584
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39734724
39Starch and sucrose metabolism_Homo sapiens_hsa005001.39472352
40Tyrosine metabolism_Homo sapiens_hsa003501.38962327
41Pyruvate metabolism_Homo sapiens_hsa006201.36188326
42Folate biosynthesis_Homo sapiens_hsa007901.33315467
43Fatty acid elongation_Homo sapiens_hsa000621.25152957
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.24491297
45ABC transporters_Homo sapiens_hsa020101.24017643
46Steroid biosynthesis_Homo sapiens_hsa001001.18795303
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.16797627
48Biosynthesis of amino acids_Homo sapiens_hsa012301.15135884
49Carbon metabolism_Homo sapiens_hsa012001.12229517
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.09131309
51Vitamin digestion and absorption_Homo sapiens_hsa049771.06593349
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02253502
53Arginine and proline metabolism_Homo sapiens_hsa003301.00087254
54Other glycan degradation_Homo sapiens_hsa005110.99871490
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99031039
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94681933
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94240032
58Sulfur relay system_Homo sapiens_hsa041220.92108311
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91984485
60Asthma_Homo sapiens_hsa053100.84926902
61Vitamin B6 metabolism_Homo sapiens_hsa007500.84690857
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.80254040
63Lysine degradation_Homo sapiens_hsa003100.78950057
64Sphingolipid metabolism_Homo sapiens_hsa006000.78895207
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77967880
66Glycerolipid metabolism_Homo sapiens_hsa005610.75100196
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74717635
68Pancreatic secretion_Homo sapiens_hsa049720.73729989
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73465119
70Glutathione metabolism_Homo sapiens_hsa004800.72607023
71One carbon pool by folate_Homo sapiens_hsa006700.67170017
72Pentose phosphate pathway_Homo sapiens_hsa000300.58294130
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55807181
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52298093
75Allograft rejection_Homo sapiens_hsa053300.51816870
76Fatty acid biosynthesis_Homo sapiens_hsa000610.49629334
77Autoimmune thyroid disease_Homo sapiens_hsa053200.48050169
78Metabolic pathways_Homo sapiens_hsa011000.47487792
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46107880
80Galactose metabolism_Homo sapiens_hsa000520.44178436
81Graft-versus-host disease_Homo sapiens_hsa053320.43129245
82Fructose and mannose metabolism_Homo sapiens_hsa000510.37411327
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33266598
84Tight junction_Homo sapiens_hsa045300.30977598
85Prion diseases_Homo sapiens_hsa050200.28584374
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.26810463
87Linoleic acid metabolism_Homo sapiens_hsa005910.26432847
88Type I diabetes mellitus_Homo sapiens_hsa049400.24303241
89Renin secretion_Homo sapiens_hsa049240.24136618
90Insulin resistance_Homo sapiens_hsa049310.22716537
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.22237990
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.19502276
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19137620
94Pertussis_Homo sapiens_hsa051330.14818932
95Antigen processing and presentation_Homo sapiens_hsa046120.14303774
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13852449
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13226098
98Cocaine addiction_Homo sapiens_hsa050300.09430372
99Leishmaniasis_Homo sapiens_hsa051400.08313630
100Renin-angiotensin system_Homo sapiens_hsa046140.08253186
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.06647405
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06287450
103Glucagon signaling pathway_Homo sapiens_hsa049220.06266944
104Mineral absorption_Homo sapiens_hsa049780.06104846
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03596530
106AMPK signaling pathway_Homo sapiens_hsa041520.00641449
107N-Glycan biosynthesis_Homo sapiens_hsa005100.00312691
108Ether lipid metabolism_Homo sapiens_hsa00565-0.2187064
109Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2100091
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.2052311
111Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1963847
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1838144
113Bladder cancer_Homo sapiens_hsa05219-0.1823922
114Regulation of autophagy_Homo sapiens_hsa04140-0.1710953
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1581187
116Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1443804
117Protein digestion and absorption_Homo sapiens_hsa04974-0.1341218
118Hepatitis C_Homo sapiens_hsa05160-0.1258988
119African trypanosomiasis_Homo sapiens_hsa05143-0.1166546
120Insulin signaling pathway_Homo sapiens_hsa04910-0.1163311
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1162004
122Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1141065
123Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0788575
124Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0452282
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0076187

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